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https://www.readbyqxmd.com/read/28409390/dynamin-related-protein-1-as-potential-therapeutic-target-in-various-diseases
#1
REVIEW
Surinder Singh, Saurabh Sharma
Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impact and molecular regulation of mitochondrial morphology. The balance between fission and fusion governs the faith of the cell. The active targeting of DRP 1 to the outer mitochondrial membrane (OMM) is done by non-GTPase receptor proteins such as mitochondrial fission factor, mitochondrial fission protein 1 and mitochondrial elongation factor 1...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28405482/the-relationship-between-serum-carbonic-anhydrase-i-ii-autoantibody-levels-and-diabetic-retinopathy-in-type-1-diabetes-patients
#2
Adem Türk, Süleyman Mollamehmetoğlu, Ahmet Alver, Ahmet Menteşe, İrfan Nuhoğlu, Cihangir Erem, Halil İbrahim İmamoğlu
OBJECTIVES: To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes. MATERIALS AND METHODS: A total of 37 type-1 diabetic patients, 17 with DRP (group 1) and 20 without (group 2), and 38 healthy control subjects (group 3) were included. CA-I and CA-II autoantibody levels were measured in serum samples obtained from each of the three groups and compared statistically...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28384228/doxycycline-protects-against-ros-induced-mitochondrial-fragmentation-and-iso-induced-heart-failure
#3
Adam Riba, Laszlo Deres, Krisztian Eros, Aliz Szabo, Klara Magyar, Balazs Sumegi, Kalman Toth, Robert Halmosi, Eszter Szabados
In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using tetracyclines, without significant side effects. Previous studies demonstrated that doxycycline (DOX), a major tetracyclin antibiotic, exerted a protective effect in animal models of heart failure; however, its exact molecular mechanism is still unknown. Here, we provide the first evidence that DOX reduces oxidative stress-induced mitochondrial fragmentation and depolarization in H9c2 cardiomyocytes and beneficially alters the expression of Mfn-2, OPA-1 and Drp-1 -the main regulators of mitochondrial fusion and fission-in our isoproterenol (ISO)-induced heart failure model, ultimately decreasing the severity of heart failure...
2017: PloS One
https://www.readbyqxmd.com/read/28380576/influence-of-cattle-trails-on-runoff-quantity-and-quality
#4
Jim J Miller, Tony Curtis, David S Chanasyk, Walter D Willms
Cattle trails in grazed pastures close to rivers may adversely affect surface water quality of the adjacent river by directing runoff to it. The objective of this 3-yr study (2013-2015) in southern Alberta, Canada, was to determine if cattle trails significantly increased the risk of runoff and contaminants (sediment, nutrients) compared with the adjacent grazed pasture (control). A portable rainfall simulator was used to generate artificial rainfall (140 mm h) and runoff. The runoff properties measured were time to runoff and initial abstraction (infiltration), total runoff depth and average runoff rates, as well as concentrations and mass loads of sediment, N, and P fractions...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28380548/phosphorus-availability-in-western-lake-erie-basin-drainage-waters-legacy-evidence-across-spatial-scales
#5
Kevin W King, Mark R Williams, Laura T Johnson, Douglas R Smith, Gregory A LaBarge, Norman R Fausey
The Western Lake Erie Basin (WLEB) was inundated with precipitation during June and July 2015 (two to three times greater than historical averages), which led to significant nutrient loading and the largest in-lake algal bloom on record. Using discharge and concentration data from three spatial scales (0.18-16,000 km), we contrast the patterns in nitrate (NO-N) and dissolved reactive phosphorus (DRP) concentration dynamics and discuss potential management implications. Across all scales, NO-N concentration steadily declined with each subsequent rainfall event as it was flushed from the system...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28380546/sediment-from-agricultural-constructed-wetland-immobilizes-soil-phosphorus
#6
Johanna Laakso, Risto Uusitalo, Janette Leppänen, Markku Yli-Halla
Phosphorus (P) losses from agricultural soils impair the quality of receiving surface waters by enhancing eutrophication. This study tested the potential of using sediment from agricultural constructed wetlands (CWs) to immobilize soil P using two soils differing in texture and soil test P (STP). A silty clay soil (SIC) with high STP (24 mg ammonium acetate-extractable P [P] L) and a sandy loam soil (SL) with excessive STP (210 mg P L) were incubated with increasing amounts of clayey CW sediment. The soil-sediment mixtures were studied with the quantity/intensity (Q/I) technique, using chemical extractions, and by exposing the mixtures to simulated rainfall...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28377602/performance-gains-in-genome-wide-association-studies-for-longitudinal-traits-via-modeling-time-varied-effects
#7
Chao Ning, Huimin Kang, Lei Zhou, Dan Wang, Haifei Wang, Aiguo Wang, Jinluan Fu, Shengli Zhang, Jianfeng Liu
Complex traits with multiple phenotypic values changing over time are called longitudinal traits. In traditional genome-wide association studies (GWAS) for longitudinal traits, a combined/averaged estimated breeding value (EBV) or deregressed proof (DRP) instead of multiple phenotypic measurements per se for each individual was frequently treated as response variable in statistical model. This can result in power losses or even inflate false positive rates (FPRs) in the detection due to failure of exploring time-dependent relationship among measurements...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28352012/clinical-variables-differentiating-diabetic-from-nondiabetic-kidney-disease-in-patients-with-diabetes-a-single-center-study
#8
Salman Imtiaz, Beena Salman, Kiran Nasir, Murtaza F Drohlia, Aasim Ahmad
Patients with diabetes may have kidney diseases other than the diabetic kidney disease. Kidney biopsy is the investigation of choice when this is suspected. This retrospective analysis included all patients known to have diabetes mellitus (DM) and who had a kidney biopsy at our center between 1998 and 2014. The aim of this study was to assess if an association exists between the clinical factors on the presence or absence of diabetic nephropathy (DNP). A total number of 206 patients were included in our study...
March 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28351625/-utilising-statutory-health-insurance-data-to-evaluate-pharmaceutical-interventions-in-secondary-care-a-pilot-study
#9
Dominik Wilke, Susanne Schiek, Thilo Bertsche, Holger Knoth
BACKGROUND: Intensive pharmaceutical and medical care can lead to fewer drug-related problems (DRPs) in hospitals. Currently available methods to track drug changes after transition from inpatient to outpatient care are susceptible to systemic bias. Therefore we analysed the feasibility of a data linkage between prescription data extracted from hospital medical records and claims data from a health insurance company. METHODS: At six Saxonian hospitals, patients with a written informed consent were consecutively assigned to a control (CG) or intervention group (IG) depending on the time of admission...
March 25, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28317138/impact-of-providing-psychiatry-specialty-pharmacist-intervention-on-reducing-drug-related-problems-among-children-with-autism-spectrum-disorder-related-to-disruptive-behavioural-symptoms-a-prospective-randomized-open-label-study
#10
R Wongpakaran, T Suansanae, T Tan-Khum, C Kraivichian, R Ongarjsakulman, C Suthisisang
WHAT IS KNOWN AND OBJECTIVES: Psychopharmacologic therapy has so far focused on ameliorating disruptive behaviours to improve patient's function and quality of life. Due to the complicated neurobiological aetiology of autism spectrum disorder (ASD), a traditional pharmacist intervention may be insufficient to initiate the optimal care for this vulnerable population. We evaluate the impact of providing specialty psychiatry (PS) pharmacist intervention in identifying and resolving drug-related problems (DRPs) among children with ASD associated with disruptive behaviours...
March 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28294974/mir-30a-as-potential-therapeutics-by-targeting-tet1-through-regulation-of-drp-1-promoter-hydroxymethylation-in-idiopathic-pulmonary-fibrosis
#11
Songzi Zhang, Huizhu Liu, Yuxia Liu, Jie Zhang, Hongbo Li, Weili Liu, Guohong Cao, Pan Xv, Jinjin Zhang, Changjun Lv, Xiaodong Song
Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of miR-30a participation in idiopathic pulmonary fibrosis (IPF) regulation is ambiguous. Our previous study demonstrated that miR-30a may function as a novel therapeutic target for lung fibrosis by blocking mitochondrial fission, which is dependent on dynamin-related protein1 (Drp-1). However, the regulatory mechanism between miR-30a and Drp-1 is yet to be investigated...
March 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28265833/direct-measurement-of-nutrient-concentrations-in-freshwaters-with-a-miniaturized-analytical-probe-evaluation-and-validation
#12
D Copetti, L Valsecchi, A G Capodaglio, G Tartari
This work deals with the evaluation of the aqueous concentrations of dissolved reactive phosphorus (DRP), total phosphorus (TP), and ammonium nitrogen (N-NH4) in surface water by means of direct online instrumentation. A portable, submersible, and automated analyzer designed to measure dissolved and total nutrient concentrations characterized by miniaturization of the entire analytical process was tested against laboratory methods. A total number of 36 water samples of different origin (i.e., rain, river, lake, and sewage waters) were analyzed and used in the comparison of DRP, TP, and N-NH4 data...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28216952/risk-factors-for-developing-drug-related-problems-in-patients-with-cardiovascular-diseases-attending-gondar-university-hospital-ethiopia
#13
Ousman Abubeker Abdela, Akshaya Srikanth Bhagavathula, Henok Getachew, Yohannes Kelifa
BACKGROUND: Cardiovascular diseases (CVDs) are often accompanied with comoribidities and complications leading to taking multiple drugs and thus are more liable to be exposed to drug-related problems (DRPs). DRPs can occur at any stages of medication process from prescription to follow-up treatment. However, a few studies have assessed the specific risk factors for occurrence of at least one potential DRP per patient with CVDs in sub-Saharan African region. AIM: We aim to assess the risk factors for developing potential DRPs in patients with CVDs attending Gondar University Referral Hospital (GUH)...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28178868/low-level-laser-effect-on-proliferation-migration-and-antiapoptosis-of-mesenchymal-stem-cells
#14
Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zhao
Mesenchymal stem cells (MSCs) have been proved to be an important element in cell-based therapy. Photobiomodulation used extremely low-level lasers (LLLs) to affect the behavior of cells. The effect mechanism of LLLs on MSCs from human remained to be discovered. In this study, cell viability was assessed using MTS assays and cell cycle was evaluated by fluorescence-activated cell sorting (FACS). The influence of LLLs on mitochondrial biogenesis (fission or fusion) and function (ATP, reactive oxygen species [ROS], nitric oxide [NO]) was evaluated by transmission electron microscope, FACS, quantitative real time polymerase chain reaction (q-PCR), and immunocytochemistry...
March 27, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28161881/nutrient-loads-from-agricultural-and-forested-areas-in-finland-from-1981-up-to-2010-can-the-efficiency-of-undertaken-water-protection-measures-seen
#15
Sirkka Tattari, Jari Koskiaho, Maiju Kosunen, Ahti Lepistö, Jarmo Linjama, Markku Puustinen
Long-term data from a network of intensively monitored research catchments in Finland was analysed. We studied temporal (1981-2010) and spatial variability in nitrogen (N) and phosphorus (P), from 1987 losses, both from agricultural and forestry land. Based on trend analysis, total nitrogen (TN) concentrations increased in two of the four agricultural sites and in most of the forested sites. In agricultural catchments, the total phosphorus (TP) trends were decreasing in two of the four catchments studied. Dissolved P (DRP) concentrations increased in two catchments and decreased in one...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28160345/does-exposure-to-opioid-substitution-treatment-in-prison-reduce-the-risk-of-death-after-release-a-national-prospective-observational-study-in-england
#16
John Marsden, Garry Stillwell, Hayley Jones, Alisha Cooper, Brian Eastwood, Michael Farrell, Tim Lowden, Nino Maddalena, Chris Metcalfe, Jenny Shaw, Matthew Hickman
BACKGROUND AND AIMS: People with opioid use disorder (OUD) in prison face an acute risk of death after release. We estimated whether prison-based opioid substitution treatment (OST) reduces this risk. DESIGN: Prospective observational cohort study using prison healthcare, national community drug misuse treatment and deaths registers. SETTING: Recruitment at 39 adult prisons in England (32 male; 7 female) accounting for 95% of OST treatment in England during study planning...
February 4, 2017: Addiction
https://www.readbyqxmd.com/read/28137399/medication-adherence-in-patients-with-juvenile-idiopathic-arthritis
#17
Liana Silveira Adriano, Marta Maria de França Fonteles, Maria de Fátima Menezes Azevedo, Milena Pontes Portela Beserra, Nirla Rodrigues Romero
OBJECTIVE: The aim of this study was to investigate pharmacological treatment adherence of patients with juvenile idiopathic arthritis, attended in an outpatient pharmacy at a tertiary hospital in northeastern Brazil. METHODS: The analysis of adherence was performed along with caregivers, through a structured questionnaire based on Morisky, Green and Levine, which enabled the categorization of adherence in "highest", "moderate" or "low" grades, and through evaluating medication dispensing registers, which classified the act of getting medications at the pharmacy as "regular" or "irregular"...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28130893/perceptions-of-psychological-abuse-versus-physical-abuse-and-their-relationship-with-mental-health-outcomes
#18
B S Sandra F Masci, Sonya Sanderson
Prior research has been limited in examining at what degree aggressive actions are initially perceived negatively. Thepresent research examined whether anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms were associated with prior abuse or with being attributed to past or present relationships. Scales such as the Dating Relationship Profile (DRP) and hypothetical scenarios of abuse perpetration were used. This study hypothesized that acceptability ratings from hypothetical scenarios would predict answers on DRP items measuring whether physical or psychological abuse is considered acceptable in relationships...
January 27, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28110617/characterization-of-drug-related-problems-occurring-in-patients-receiving-outpatient-antimicrobial-therapy
#19
Cory M Hale, Jeffrey M Steele, Robert W Seabury, Christopher D Miller
BACKGROUND: Despite the numerous benefits of outpatient parenteral antimicrobial therapy (OPAT), appreciable risks of drug-related problems (DRPs) exist. No studies to date comprehensively assess DRPs in this population. OBJECTIVES: Objectives of this study were to (1) characterize the frequency and types of DRPs experienced by patients discharged on OPAT and (2) determine the fraction of adverse drug reactions (ADRs) resulting in hospital readmission or emergency department (ED) presentation and changes in therapy...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28104969/assessment-of-a-clinical-pharmacy-activity-in-a-pediatric-inpatient-department-in-cote-d-ivoire
#20
Danho Pascal Abrogoua, César Pacôme Békégnran, Bi Marius Gro, Elisée Doffou, Madeleine Amorissani Folquet
BACKGROUND: Clinical pharmacy activities in a pediatric inpatient department help to improve the management of patients clinically and economically. OBJECTIVE: To assess the relevance of pharmaceutical interventions (PIs) in a pediatric inpatient department in Abidjan (Cote d'Ivoire). MATERIALS AND METHODS: We carried out a cross-sectional, descriptive study from February to September 2014. The information collected was classified according to the classification of drug-related problems (DRPs) and PIs of the French Society of Clinical Pharmacy...
December 2016: Journal of Basic and Clinical Pharmacy
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