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https://www.readbyqxmd.com/read/29429957/a-non-apoptotic-function-of-mcl-1-in-promoting-pluripotency-and-modulating-mitochondrial-dynamics-in-stem-cells
#1
Megan L Rasmussen, Leigh A Kline, Kyungho P Park, Natalya A Ortolano, Alejandra I Romero-Morales, Christin C Anthony, Kathryn E Beckermann, Vivian Gama
Human pluripotent stem cells (hPSCs) maintain a highly fragmented mitochondrial network, but the mechanisms regulating this phenotype remain unknown. Here, we describe a non-cell death function of the anti-apoptotic protein, MCL-1, in regulating mitochondrial dynamics and promoting pluripotency of stem cells. MCL-1 is induced upon reprogramming, and its inhibition or knockdown induces dramatic changes to the mitochondrial network as well as loss of the key pluripotency transcription factors, NANOG and OCT4...
January 31, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29421824/the-main-determinants-of-serum-resistin-level-in-type-2-diabetic-patients-are-renal-function-and-inflammation-not-presence-of-microvascular-complication-obesity-and-insulin-resistance
#2
Egemen Cebeci, Cengiz Cakan, Meltem Gursu, Sami Uzun, Serhat Karadag, Macit Koldas, Turan Calhan, Serife Aysen Helvaci, Savas Ozturk
AIM: The association of increased resistin levels in chronic kidney disease with diabetic nephropathy has not yet been clarified. Our aim was to analyze the relationship between serum resistin levels and various diabetic microvascular complications in patients. METHODS: A total of 83 patients were enrolled in this cross-sectional study. The subjects were divided into 3 groups: 27 patients with type 2 diabetes mellitus (T2DM) having no diabetic retinopathy (DRP) or microalbuminuria and having normal renal function were included in Group-1, 28 patients with T2DM having DRP and normal renal function in Group-2, and 28 patients with T2DM with DRP and microalbuminuria and an estimated glomerular filtration rate (eGFR) of<60 ml/min/1...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29419407/hyperoxia-causes-mitochondrial-fragmentation-in-pulmonary-endothelial-cells-by-increasing-expression-of-pro-fission-proteins
#3
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29414102/drp-1-dependent-mitochondrial-fragmentation-and-protective-autophagy-in-dopaminergic-sh-sy5y-cells-overexpressing-alpha-synuclein
#4
Jimena Hebe Martinez, Agustina Alaimo, Roxana Mayra Gorojod, Soledad Porte Alcon, Federico Fuentes, Federico Coluccio Leskow, Mónica Lidia Kotler
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the Lewy bodies. Additional common features of this disease are the mitochondrial dysfunction and the activation/inhibition of autophagy both events associated to the intracellular accumulation of α-synuclein. The mechanism by which these events contribute to neural degeneration remains unknown...
January 27, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29391262/quercetogetin-protects-against-cigarette-smoke-extract-induced-apoptosis-in-epithelial-cells-by-inhibiting-mitophagy
#5
Eun Suk Son, Se-Hee Kim, Stefan W Ryter, Eui-Ju Yeo, Sun Young Kyung, Yu Jin Kim, Sung Hwan Jeong, Chang Soo Lee, Jeong-Woong Park
Recent studies demonstrate that the autophagy-dependent turnover of mitochondria (mitophagy) mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure, and contributes to emphysema development in vivo during chronic cigarette smoke (CS)-exposure, although the underlying mechanisms remain unclear. Here, we investigated the role of mitophagy in regulating apoptosis in CSE-exposed human lung bronchial epithelial cells. Furthermore, we investigated the potential of the polymethoxylated flavone antioxidant quercetogetin (QUE) to inhibit CSE-induced mitophagy-dependent apoptosis...
January 29, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29380236/drug-related-problems-identified-by-clinical-pharmacist-at-the-internal-medicine-ward-in-turkey
#6
Nibal Abunahlah, Anfal Elawaisi, Fatih Mehmet Velibeyoglu, Mesut Sancar
Background Drug-related problems (DRPs) interfere with patient optimal therapeutic outcomes and may be associated with higher morbidity, mortality and healthcare expenditures. Objective This study aimed to identify DRPs and their causes in a Turkish hospital. Setting Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Internal Medicine Ward, Istanbul, Turkey. Method Cross-sectional study included a total of 100 patients. Patient demographics, medications, and history were evaluated. Data regarding recent medications were analyzed by two clinical pharmacists and an Internal Medicine physician...
January 29, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29375764/is-didymosphenia-geminata-an-introduced-species-in-new-zealand-evidence-from-trends-in-water-chemistry-and-chloroplast-dna
#7
Cathy Kilroy, Phil Novis
Defining the geographic origins of free-living aquatic microorganisms can be problematic because many such organisms have ubiquitous distributions, and proving absence from a region is practically impossible. Geographic origins become important if microorganisms have invasive characteristics. The freshwater diatom Didymosphenia geminata is a potentially ubiquitous microorganism for which the recent global expansion of nuisance proliferations has been attributed to environmental change. The changes may include declines in dissolved reactive phosphorus (DRP) to low levels (e...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29360576/scribble-scrib-knockdown-induces-tumorigenesis-by-modulating-drp1-parkin-mediated-mitochondrial-dynamics-in-the-wing-imaginal-tissues-of-drosophila
#8
Amarish Kumar Yadav, Saripella Srikrishna
scrib loss of function is associated with various human-cancers. Most of the human-cancers have been characterized by mitochondrial dysfunction with elevated oxidative stress. However, the role of scrib to mitochondrial dysfunction in cancer has not been investigated earlier. Here, we have shown that scrib knockdown leads to mitochondrial depolarization, fragmentation and perinuclear-clustering along with disruption of the redox homeostasis. Moreover, the scrib abrogated tumor showed the elevation of Drp-1 and reduced expression of Marf, which suggests enhanced mitochondrial-fission...
January 19, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29340850/drug-related-problems-among-community-dwelling-older-adults-in-mainland-china
#9
Jiadan Yang, Long Meng, Yu Liu, Liping Lv, Shusen Sun, Rui Long, Xuefeng Shan, Jie Song, Feng Qiu
Background Little is known about the extent of drug-related problems (DRPs) in community-dwelling older adult patients with chronic diseases in mainland China. Setting A medication therapy review service at a community health center in Chongqing, China. Objective To identify and categorize DRPs along with pharmacists' recommendations in addressing the DRPs identified. Method The study was conducted between May 2015 and July 2016. A total of 102 community-dwelling older adults were included. MTR was carried out by clinical pharmacists...
January 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29331535/estrogen-deprivation-aggravates-cardiometabolic-dysfunction-in-obese-insulin-resistant-rats-through-the-impairment-of-cardiac-mitochondrial-dynamics
#10
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29327177/influence-of-sampling-frequency-and-load-calculation-methods-on-quantification-of-annual-river-nutrient-and-suspended-solids-loads
#11
Ahmed Elwan, Ranvir Singh, Maree Patterson, Jon Roygard, Dave Horne, Brent Clothier, Geoffrey Jones
Better management of water quality in streams, rivers and lakes requires precise and accurate estimates of different contaminant loads. We assessed four sampling frequencies (2 days, weekly, fortnightly and monthly) and five load calculation methods (global mean (GM), rating curve (RC), ratio estimator (RE), flow-stratified (FS) and flow-weighted (FW)) to quantify loads of nitrate-nitrogen (NO3--N), soluble inorganic nitrogen (SIN), total nitrogen (TN), dissolved reactive phosphorus (DRP), total phosphorus (TP) and total suspended solids (TSS), in the Manawatu River, New Zealand...
January 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29311437/cross-sectional-internet-based-survey-of-japanese-permanent-daytime-workers-sleep-and-daily-rest-periods
#12
Hiroki Ikeda, Tomohide Kubo, Takeshi Sasaki, Xinxin Liu, Tomoaki Matsuo, Rina So, Shun Matsumoto, Takashi Yamauchi, Masaya Takahashi
OBJECTIVES: This study aimed to describe the sleep quantity, sleep quality, and daily rest periods (DRPs) of Japanese permanent daytime workers. METHODS: Information about the usual DRP, sleep quantity, and sleep quality (Japanese version of the Pittsburgh Sleep Quality Index: PSQI-J) of 3867 permanent daytime workers in Japan was gathered through an Internet-based survey. This information was analyzed and divided into the following eight DRP groups: <10, 10, 11, 12, 13, 14, 15, and ≥16 h...
December 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29245958/apelin-protects-against-myocardial-ischemic-injury-by-inhibiting-dynamin-related-protein-1
#13
Wei Xu, Hongwei Yu, Ruixue Ma, Lina Ma, Qiushuang Liu, Huitong Shan, Chengyu Wu, Rong Zhang, Yuhong Zhou, Hongli Shan
It is known that dynamin-related protein 1 (Drp1)-mediated mitochondrial fission plays an important role in ischemic injury of myocardial infarction (MI). Apelin, an endogenous ligand for Apelin receptor, acts as a key modulator of cardiovascular diseases. Here, we examined the effects of Apelin on MI injury and underlying mechanisms. Adult male C57BL/6J mice were treated with Apelin for 4 weeks and then subjected coronary artery ligation (LAD) to induce MI and the protective effects of Apelin on MI injury were evaluated at 6 h post LAD...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29239493/mortality-in-patients-with-community-onset-pneumonia-at-low-risk-of-drug-resistant-pathogens-impact-of-%C3%AE-lactam-plus-macrolide-combination-therapy
#14
Junya Okumura, Yuichiro Shindo, Kunihiko Takahashi, Masahiro Sano, Yasuteru Sugino, Tetsuya Yagi, Hiroyuki Taniguchi, Hideo Saka, Shigeyuki Matsui, Yoshinori Hasegawa
BACKGROUND AND OBJECTIVE: Drug-resistant pathogen (DRP) risk stratification is important for choosing a treatment strategy for community-onset pneumonia. Evidence for benefits of non-antipseudomonal β-lactam plus macrolide combination therapy (BLM) on mortality is limited in patients at low DRP risk. Risk factors for mortality remain to be clarified. METHODS: Post hoc analysis using a prospective multicentre study cohort of community-onset pneumonia was performed to assess 30-day differences in mortality between non-antipseudomonal β-lactam monotherapy (BL) and BLM groups...
December 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29233313/pharmacy-student-involvement-in-a-transition-of-care-program
#15
Raquel Hertig, Rina Ackerman, Brenda Zagar, Serina Tart
BACKGROUND AND PURPOSE: Cape Fear Valley Medical Center (CFVMC) implemented a Community Paramedic Program (CPP) to improve the transition of hospitalized patients to the home setting. In this program, paramedics conduct home visits for 30 days after qualifying patients are discharged. This article describes pharmacy services provided to CPP patients by fourth-year pharmacy students on Advanced Pharmacy Practice Experiences (APPE) that assisted with home visits. EDUCATIONAL ACTIVITY AND SETTING: Students were oriented to the CPP and patient interview technique was assessed through a role-play scenario...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29223917/molecular-dynamics-simulations-suggest-changes-in-electrostatic-interactions-as-a-potential-mechanism-through-which-serine-phosphorylation-inhibits-dna-polymerase-%C3%AE-s-activity
#16
Dirar Homouz, Kwee Hong Joyce-Tan, Mohd Shahir Shamsir, Ibrahim M Moustafa, Haitham Idriss
DNA polymerase β is a 39kDa enzyme that is a major component of Base Excision Repair in human cells. The enzyme comprises two major domains, a 31kDa domain responsible for the polymerase activity and an 8kDa domain, which bind ssDNA and has a deoxyribose phosphate (dRP) lyase activity. DNA polymerase β was shown to be phosphorylated in vitro with protein kinase C (PKC) at serines 44 and 55 (S44 and S55), resulting in loss of its polymerase enzymic activity, but not its ability to bind ssDNA. In this study, we investigate the potential phosphorylation-induced structural changes for DNA polymerase β using molecular dynamics...
November 7, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29223396/accelerated-dentinogenesis-by-inhibiting-the-mitochondrial-fission-factor-dynamin-related-protein-1
#17
Yumiko Matsuishi, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Hiroko Wada, Tamotsu Kiyoshima, Kazuaki Nonaka
Undifferentiated odontogenic epithelium and dental papilla cells differentiate into ameloblasts and odontoblasts, respectively, both of which are essential for tooth development. These differentiation processes involve dramatic functional and morphological changes of the cells. For these changes to occur, activation of mitochondrial functions, including ATP production, is extremely important. In addition, these changes are closely related to mitochondrial fission and fusion, known as mitochondrial dynamics...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29194460/dynamical-system-modeling-to-simulate-donor-t-cell-response-to-whole-exome-sequencing-derived-recipient-peptides-understanding-randomness-in-alloreactivity-incidence-following-stem-cell-transplantation
#18
Vishal Koparde, Badar Abdul Razzaq, Tara Suntum, Roy Sabo, Allison Scalora, Myrna Serrano, Max Jameson-Lee, Charles Hall, David Kobulnicky, Nihar Sheth, Juliana Feltz, Daniel Contaifer, Dayanjan Wijesinghe, Jason Reed, Catherine Roberts, Rehan Qayyum, Gregory Buck, Michael Neale, Amir Toor
Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p<0...
2017: PloS One
https://www.readbyqxmd.com/read/29192500/comparative-proteomics-of-contrasting-maize-genotypes-provides-insights-into-salt-stress-tolerance-mechanisms
#19
Meijie Luo, Yanxin Zhao, Yuandong Wang, Zi Shi, Panpan Zhang, Yunxia Zhang, Wei Song, Jiuran Zhao
Salt stress is a major abiotic factor limiting maize yield. To characterize the mechanism underlying maize salt tolerance, we compared the seedling root proteomes of salt-tolerant Jing724 and salt-sensitive D9H. The germination rate and growth parameter values (weight and length) were higher for Jing724 than for D9H under saline conditions. Using an iTRAQ-based method, we identified 513 differentially regulated proteins (DRPs), with 83 and 386 DRPs specific to Jing724 and D9H, respectively. In salt-stressed Jing724, the DRPs were primarily associated with the pentose phosphate pathway, glutathione metabolism, and nitrogen metabolism...
December 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29190741/preoperative-transcranial-direct-current-stimulation-exploration-of-a-novel-strategy-to-enhance-neuroplasticity-before-surgery-to-control-postoperative-pain-a-randomized-sham-controlled-study
#20
Hugo Ribeiro, Ricardo Bertol Sesterhenn, Andressa de Souza, Ana Claudia de Souza, Monique Alves, Jessica Catarina Machado, Nathalia Bofill Burger, Iraci Lucena da Silva Torres, Luciana Cadore Stefani, Felipe Fregni, Wolnei Caumo
BACKGROUND: An imbalance in the excitatory/inhibitory systems in the pain networks may explain the persistent chronic pain after hallux valgus surgery. Thus, to contra-regulate this dysfunction, the use of transcranial direct current stimulation (tDCS) becomes attractive. OBJECTIVE: We tested the hypothesis that two preoperative active(a)-tDCS sessions compared with sham(s)-tDCS could improve the postoperative pain [as indexed by Visual Analogue Scale (VAS) at rest and during walking (primary outcomes)]...
2017: PloS One
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