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https://www.readbyqxmd.com/read/27932550/spermaurin-an-la1-like-peptide-from-the-venom-of-the-scorpion-scorpio-maurus-palmatus-improves-sperm-motility-and-fertilization-in-different-mammalian-species
#1
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27924735/-clinical-medication-reviews-in-elderly-patients-with-polypharmacy-a-cross-sectional-study-in-dutch-community-pharmacies
#2
S H Chau, A P D Jansen, P M van de Ven, P Hoogland, P J M Elders, J G Hugtenburg
OBJECTIVE: To investigate the nature and prevalence of drug related problems (DRPs) in older patients with polypharmacy identified by community pharmacists in daily practice through means of a clinical medication review (CMR) and assess the implementation rate of proposed interventions to solve DRPs. DESIGN: A cross-sectional study METHOD: We analysed the CMR data of 3,807 older patients (≥ 65 years) with polypharmacy (≥ 5 drugs) completed in January-August 2012...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27916134/underway-analysis-of-nanomolar-dissolved-reactive-phosphorus-in-oligotrophic-seawater-with-automated-on-line-solid-phase-extraction-and-spectrophotometric-system
#3
Jian Ma, Yuan Yuan, Dongxing Yuan
The automated in-field determination of trace phosphate (and other nutrients) is highly valuable for studying nutrient dynamics and cycling in oligotrophic oceans. Here, we report an automated portable analyzer for week-long underway analysis of nanomolar dissolved reactive phosphorus (DRP) in seawater. The method is based on classic phosphomolybdenum blue (PMB) chemistry combined with on-line solid phase extraction (SPE) and flow analysis. Under optimized conditions, the formed PMB from sample is automatically concentrated on a hydrophilic lipophilic balanced (HLB) copolymer SPE...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27894227/multidisciplinary-teams-involved-detection-of-drug-related-problems-through-continuity-of-care
#4
Elena Yaiza Romero-Ventosa, Marisol Samartín-Ucha, Alicia Martín-Vila, María Lucía Martínez-Sánchez, Isabel Rey Gómez-Serranillos, Guadalupe Pineiro-Corrales
OBJECTIVE: To quantify Drug-Related problems (DRPs) by establishing a Strategic Continuity of Care Program (e-Conecta- Concilia Program; e-CC) focused on the drug therapy of patients within an Integrated Management Structure, in order to guarantee the therapeutical efficiency, safety and traceability of patients. METHOD: A prospective study at 8 months. The project included 22 Hospital Pharmacists and 12 Primary Care Pharmacists. Electronic clinical records were used, which can be accessed by all healthcare levels...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27881076/clustering-of-disulfide-rich-peptides-provides-scaffolds-for-hit-discovery-by-phage-display-application-to-interleukin-23
#5
David T Barkan, Xiao-Li Cheng, Herodion Celino, Tran T Tran, Ashok Bhandari, Charles S Craik, Andrej Sali, Mark L Smythe
BACKGROUND: Disulfide-rich peptides (DRPs) are found throughout nature. They are suitable scaffolds for drug development due to their small cores, whose disulfide bonds impart extraordinary chemical and biological stability. A challenge in developing a DRP therapeutic is to engineer binding to a specific target. This challenge can be overcome by (i) sampling the large sequence space of a given scaffold through a phage display library and by (ii) panning multiple libraries encoding structurally distinct scaffolds...
November 23, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27826296/physical-factors-correlate-to-microbial-community-structure-and-nitrogen-cycling-gene-abundance-in-a-nitrate-fed-eutrophic-lagoon
#6
Matthew P Highton, Stéphanie Roosa, Josie Crawshaw, Marc Schallenberg, Sergio E Morales
Nitrogenous run-off from farmed pastures contributes to the eutrophication of Lake Ellesmere, a large shallow lagoon/lake on the east coast of New Zealand. Tributaries periodically deliver high loads of nitrate to the lake which likely affect microbial communities therein. We hypothesized that a nutrient gradient would form from the potential sources (tributaries) creating a disturbance resulting in changes in microbial community structure. To test this we first determined the existence of such a gradient but found only a weak nitrogen (TN) and phosphorous gradient (DRP)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27816566/medication-review-in-german-community-pharmacies-post-hoc-analysis-of-documented-drug-related-problems-and-subsequent-interventions-in-the-athina-project
#7
Hanna Marita Seidling, Alexander Francesco Josef Send, Janina Bittmann, Katja Renner, Bernd Dewald, Dörte Lange, Thomas Bruckner, Walter Emil Haefeli
BACKGROUND: Any medication can cause drug-related problems (DRPs), which can often be detected by medication reviews. So far, only limited information is available on the practicability of systematic medication reviews in community pharmacies in daily routine and their value in Germany. Since 2012, the community pharmacy-centered medication review project "ATHINA - Arzneimitteltherapiesicherheit in Apotheken [medication safety in community pharmacies]" is endorsed by four Chambers of Pharmacists in Germany...
October 24, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27807421/cancer-and-chemotherapy-contribute-to-muscle-loss-by-activating-common-signaling-pathways
#8
Rafael Barreto, Giorgia Mandili, Frank A Witzmann, Francesco Novelli, Teresa A Zimmers, Andrea Bonetto
Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that chemotherapeutic regimens, such as Folfiri, contribute to cachexia-related symptoms. The purpose of the present study was to investigate the cachexia signature in different conditions associated with severe muscle wasting, namely Colon-26 (C26) and Folfiri-associated cachexia. Using a quantitative LC-MS/MS approach, we identified significant changes in 386 proteins in the quadriceps muscle of Folfiri-treated mice, and 269 proteins differentially expressed in the C26 hosts (p < 0...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27802433/targeting-dynamin-2-as-a-novel-pathway-to-inhibit-cardiomyocyte-apoptosis-following-oxidative-stress
#9
Danchen Gao, Jian Yang, Yutao Wu, Qiwen Wang, Qiaoling Wang, En Yin Lai, Jianhua Zhu
BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. It remains unknown if Dynamin 2 inhibition results in similar protective effects. Here we studied the role of Dynamin 2 in cardiomyocyte oxidative stress-induced apoptosis and ROS production. METHODS: The effect of lentiviral shRNA (lv5-shRNA) mediated Dynamin 2 knockdown on apopotosis, mitochondria, and ROS production were studied in neonatal mouse cardiomycytes, which were further treated with either selective Drp1 inhibitor mdivi-1 or the Dynamin 2/Drp1 inhibitor Dynasore...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27783313/the-status-of-the-performance-of-medication-reviews-in-german-community-pharmacies-and-assessment-of-the-practical-performance
#10
Claudia Greißing, Katharina Kössler, Johanna Freyer, Lucie Hüter, Peter Buchal, Susanne Schiek, Thilo Bertsche
Background Pharmacist-led medication reviews have shown to prevent drug-related problems (DRPs). So far, data is rare about the implementation in routine care, the conditions for intensifying this service and the practical skills of community pharmacists to perform medication reviews. Objective To assess the current status of medication review implementation in German community pharmacies and the performance of identifying DRPs in a ficticious patient example. Setting German community pharmacies. Method An online survey was conducted from July to September 2015 including questions about medication reviews currently performed in routine care of community pharmacies and hidden DRPs in a ficticious patient example...
October 25, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27778374/prevalence-of-drug-related-problems-associated-with-direct-oral-anticoagulants-in-hospitalized-patients-a-multicenter-cross-sectional-study
#11
M Viprey, R Jeannin, V Piriou, P Chevalier, C Michel, G Aulagner, J Berthiller, X Armoiry
WHAT IS KNOWN AND OBJECTIVE: The complex dose regimens of the direct-acting oral anticoagulants (DOAC) make their appropriate prescribing highly challenging. Inappropriate prescribing of the DOAC remains poorly addressed. We studied the patterns of DOAC prescription and estimated the prevalence of drug-related problems (DRPs) associated with their use. METHODS: A cross-sectional study was conducted using data from medical records system of the Lyon teaching hospitals...
October 24, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27747806/drug-related-problems-identified-in-a-sample-of-portuguese-institutionalised-elderly-patients-and-pharmacists-interventions-to-improve-safety-and-effectiveness-of-medicines
#12
Filipa Alves da Costa, Luísa Silvestre, Catarina Periquito, Clara Carneiro, Pedro Oliveira, Ana Isabel Fernandes, Patrícia Cavaco-Silva
BACKGROUND: Currently, people live longer but often with poor quality of life. The decrease in healthy life-years is partly attributable to the institution of polypharmacy to treat various comorbidities. OBJECTIVES: The objectives of the study were to determine the prevalence and nature of drug-related problems (DRPs) in polypharmacy elderly patients residing in nursing homes and to test the acceptability of a pharmacist's intervention. METHODS: An exposure cohort was constituted in three Portuguese nursing homes, where all polypharmacy (five or more medicines) elderly patients (≥65 years of age) were analysed and then a random stratified sample was extracted to be subject to an intervention...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27741935/effect-of-inhibiting-mitochondrial-fission-on-energy-metabolism-in-rat-hippocampal-neurons-during-ischemia-reperfusion-injury
#13
Yu Li, Min Wang, Shilei Wang
OBJECTIVE: Previous studies have shown that mitochondrial division inhibitor 1 (mdivi-1) protects rat brain from ischemia/reperfusion (I/R) injury, but the precise mechanisms are unclear. This study aims to elucidate the effect of mdivi-1 on energy metabolism and neuronal apoptosis induced by I/R in vitro. METHODS: Cultured hippocampal neurons from Wistar rats were randomly divided into four treatment groups: control (C), vehicle (V), I/R (I), and I/R plus mdivi-1 (M)...
October 14, 2016: Neurological Research
https://www.readbyqxmd.com/read/27731374/exercise-training-alleviates-hypoxia-induced-mitochondrial-dysfunction-in-the-lymphocytes-of-sedentary-males
#14
Hsing-Hua Tsai, Shao-Chiang Chang, Cheng-Hsien Chou, Tzu-Pin Weng, Chih-Chin Hsu, Jong-Shyan Wang
This study elucidates how interval and continuous exercise regimens affect the mitochondrial functionality of lymphocytes under hypoxic stress. Sixty healthy sedentary males were randomly assigned to engage in either high-intensity interval training (HIIT, 3 min intervals at 80% and 40% VO2max, n = 20) or moderate-intensity continuous training (MICT, sustained 60% VO2max, n = 20) for 30 min/day, 5 days/week for 6 weeks or were assigned to a control group that did not receive exercise intervention (n = 20)...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27730699/cross-sectional-investigation-of-drug-related-problems-among-adults-in-a-medical-center-outpatient-clinic-application-of-virtual-medicine-records-in-the-cloud
#15
Hue-Yu Wang, Ming-Kung Yeh, Chung-Han Ho, Ming-Kuan Hu, Yaw-Bin Huang
PURPOSE: To analyze and characterize data regarding the prevalence and types of outpatient drug-related problems (DRPs) found by clinical pharmacists after implementation of the Virtual Medicine Record in Cloud System (VMRCS). METHODS: A cross-sectional study regarding outpatient pharmaceutical care was conducted at a medical center in Taiwan. Patients aged >20 years old with multiple chronic diseases and polypharmacy were enrolled. In Stage I (1 October-31 December 2014), patients received pharmaceutical care according to prescription data accessed online in the VMRCS...
October 12, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27721536/drug-related-problems-associated-with-self-medication-and-medication-guided-by-prescription-a-pharmacy-based-survey
#16
Abinash Panda, Supriya Pradhan, Gurukrushna Mohapatra, Jigyansa Mohapatra
OBJECTIVES: The objective of this study is to identify and compare the nature of the drug-related problems (DRPs) associated with self-medication and non-self-medication (drug use guided by a prescription). MATERIALS AND METHODS: The cross-sectional, observational study was conducted on 1100 adult participants at a convenience sample of six retail private pharmacy counters. The data collection form was based on the Pharmaceutical Care Network Europe version 6.2 classification for DRPs...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27707666/dissolved-reactive-phosphorus-played-a-limited-role-in-phosphorus-transport-via-runoff-throughflow-and-leaching-on-contrasting-cropping-soils-from-southwest-australia
#17
R Sharma, R W Bella, M T F Wong
PURPOSE: Phosphorus (P) lost from agricultural land by erosion, runoff, throughflow and leaching is of major concern for water resource managers worldwide. Previous study on soils from cropping land of southwest Western Australia suggested P loss as dissolved unreactive P (DURP) via leaching, but the implications for processes and rates of P transport in soils are not known. MATERIAL AND METHODS: Two contrasting soil profiles (sand and loam) from cropping land of southwest Western Australia were exposed to artificial rain in packed boxes and field runoff plots to examine P forms and fluxes in runoff, throughflow, leachate and soil solution after three P rates of application (equivalent to 0, 20 and 40kg P/ha)...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27702866/safety-and-efficacy-of-applying-a-low-dose-radiation-fluoroscopy-protocol-in-device-implantations
#18
Philipp Attanasio, Melika Mirdamadi, Jean-Yves Wielandts, Burkert Pieske, Florian Blaschke, Leif-Hendrik Boldt, Pierre Jais, Wilhelm Haverkamp, Martin Huemer
AIMS: For cardiac implantable electronic device (CIED) implantations, visualization of lead placement is necessary and fluoroscopy remains by far the most commonly used technique. With simple changes in the X-ray system settings, total radiation dose can be reduced significantly. The purpose of this study was to assess the safety and efficacy of various CIED implantations performed after implementation of a new dose reduction protocol (DRP). METHODS AND RESULTS: We conducted a retrospective chart review of 584 patients undergoing CIED implantation or revision in our hospital...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27695765/decreasing-phosphorus-loss-in-tile-drained-landscapes-using-flue-gas-desulfurization-gypsum
#19
K W King, M R Williams, W A Dick, G A LaBarge
Elevated phosphorus (P) loading from agricultural nonpoint-source pollution continues to impair inland waterbodies throughout the world. The application of flue gas desulfurization (FGD) gypsum to agricultural fields has been suggested to decrease P loading because of its high calcium content and P sorbing potential. A before-after control-impact paired field experiment was used to examine the water quality effects of successive FGD gypsum applications (2.24 Mg ha; 1 ton acre each) to an Ohio field with high soil test P levels (>480 ppm Mehlich-3 P)...
September 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27683219/rev1-is-a-base-excision-repair-enzyme-with-5-deoxyribose-phosphate-lyase-activity
#20
Rajendra Prasad, Vladimir Poltoratsky, Esther W Hou, Samuel H Wilson
Rev1 is a member of the Y-family of DNA polymerases and is known for its deoxycytidyl transferase activity that incorporates dCMP into DNA and its ability to function as a scaffold factor for other Y-family polymerases in translesion bypass events. Rev1 also is involved in mutagenic processes during somatic hypermutation of immunoglobulin genes. In light of the mutation pattern consistent with dCMP insertion observed earlier in mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned whether Rev1 could also be involved in base excision repair (BER)...
September 28, 2016: Nucleic Acids Research
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