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https://www.readbyqxmd.com/read/29672985/the-impact-of-buprenorphine-and-methadone-on-mortality-a-primary-care-cohort-study-in-the-united-kingdom
#1
Matthew Hickman, Colin Steer, Kate Tilling, Aaron G Lim, John Marsden, Tim Millar, John Strang, Maggie Telfer, Peter Vickerman, John Macleod
AIMS: To estimate whether opioid substitution treatment (OST) with buprenorphine or methadone is associated with a greater reduction in the risk of all-cause mortality (ACM) and opioid drug-related poisoning (DRP) mortality. DESIGN: Cohort study with linkage between clinical records from Clinical Practice Research Datalink and mortality register. SETTING: UK primary care. PARTICIPANTS: A total of 11 033 opioid-dependent patients who received OST from 1998 to 2014, followed-up for 30 410 person-years...
April 19, 2018: Addiction
https://www.readbyqxmd.com/read/29666686/evaluation-of-a-clinical-pharmacist-intervention-on-clinical-and-drug-related-problems-among-coronary-heart-disease-inpatients-a-pre-experimental-prospective-study-at-a-general-hospital-in-indonesia
#2
Vina A Sagita, Anton Bahtiar, Retnosari Andrajati
Objectives: This study aimed to evaluate the role of a clinical pharmacist intervention in decreasing subsequent clinical and drug-related problems (DRPs) among coronary heart disease (CHD) inpatients with at least one previous DRP. Methods: This pre-experimental study with a pre-post design was carried out from January to April 2017 among inpatients with at least one previous DRP at a general hospital in Tangerang District, Banten, Indonesia. Clinical and DRPs were documented prospectively by a clinical pharmacist, with DRPs classified using Version 6...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29625008/study-of-the-lyase-activity-of-human-dna-polymerase-%C3%AE-using-analogues-of-the-intermediate-schiff-base-complex
#3
Sasha M Daskalova, Xiaoguang Bai, Sidney M Hecht
DNA polymerase β (Pol β) participates in mammalian base excision repair (BER). The enzyme has a two-domain architecture, reflecting its dual functionality. The polymerase activity, which replaces damaged nucleosides removed during an initial excision process, is within the C-terminal 31 kDa domain, while the N-terminal 8 kDa domain participates in a lyase function, working to remove a 5'-deoxyribose phosphate (5'-dRP) moiety from the damaged DNA substrate. The currently accepted mechanism of the lyase reaction involves a transient covalent enzyme‒DNA intermediate in the form of a Schiff base connecting Lys72 of the enzyme with the 5'-dRP moiety...
April 6, 2018: Biochemistry
https://www.readbyqxmd.com/read/29600335/radiation-exposure-for-intraoperative-3d-scans-in-a-hybrid-operating-room-how-to-reduce-radiation-exposure-for-the-surgical-team
#4
K Schuetze, M Kraus, A Eickhoff, F Gebhard, P H Richter
BACKGROUND: Hybrid operating rooms are used in different fields of surgery. In orthopedic surgery, the possibility of a 3D scan of difficult anatomical regions (spine, pelvis) showed promising results not only in navigated screw placement. The associated exposure to radiation raises questions regarding potential risks for the operating room personal and the patient. The present study focuses on scatter radiation during 3D scans in a hybrid operating room, the adjacent rooms, and methods to reduce radiation exposure...
March 29, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29582192/prevalence-and-risk-of-polypharmacy-among-elderly-cancer-patients-receiving-chemotherapy-in-ambulatory-oncology-setting
#5
REVIEW
Ivy Goh, Olive Lai, Lita Chew
PURPOSE OF REVIEW: This was a single center, retrospective cross-sectional study looking into the incidence and types of drug-related problems (DRPs) detected among elderly cancer patients receiving at least three long-term medications concurrent with IV chemotherapy, and the types of intervention taken to address these DRPs. This paper serves to elucidate the prevalence and risk of polypharmacy in our geriatric oncology population in an ambulatory care setting, to raise awareness on this growing issue and to encourage more resource allocation to address this healthcare phenomenon...
March 26, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29572068/polygodial-analog-induces-apoptosis-in-lncap-prostate-cancer-cells
#6
Subramanyam Dasari, Angela Lincy Prem Antony Samy, Parnal Narvekar, Venkata Satish Dontaraju, Ramesh Dasari, Alexander Kornienko, Gnanasekar Munirathinam
Prostate cancer (PCa) is the second leading cause of death in American men. The chemotherapeutic treatment strategies are generally not effective and can lead to side effects. Hence, there is an urgent need to identify novel chemotherapeutic agents. The aim of this study was to synthesize and evaluate the therapeutic effects of a synthetic analog of polygodial (PG), a pungent constituent abundantly present in mountain pepper, water pepper and dorrigo pepper, on LNCaP PCa cell line and its anti-cancer mechanisms in a preclinical study...
March 20, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29563796/biosynthesis-of-au-ag-and-au-ag-bimetallic-nanoparticles-using-protein-extracts-of-deinococcus-radiodurans-and-evaluation-of-their-cytotoxicity
#7
Jiulong Li, Bing Tian, Tao Li, Shang Dai, Yulan Weng, Jianjiang Lu, Xiaolin Xu, Ye Jin, Renjiang Pang, Yuejin Hua
Background: Biosynthesis of noble metallic nanoparticles (NPs) has attracted significant interest due to their environmental friendly and biocompatible properties. Methods: In this study, we investigated syntheses of Au, Ag and Au-Ag bimetallic NPs using protein extracts of Deinococcus radiodurans , which demonstrated powerful metal-reducing ability. The obtained NPs were characterized and analyzed by various spectroscopy techniques. Results: The D...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29555106/pharmacists-interventions-on-prescription-problems-in-one-french-community-pharmacy-a-prospective-pilot-study
#8
A Castronovo, F Gervais, C Mongaret, F Slimano
OBJECTIVES: While many international studies widely describe pharmacists' interventions (PIs) on drug-related problems (DRP) in community pharmacies, in France, these activities are underreported. The aim of this study is to describe the PI rate, given as the number of interventions in among all prescriptions reviewed during the study period. MATERIAL AND METHODS: This study was conducted in one French rural community pharmacy during a 7-month period. Age, sex, type of prescriber, type of problems, intervention and the outcome were prospectively recorded...
March 16, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29542035/pharmacists-in-general-practice-a-focus-on-drug-related-problems
#9
Helen Benson, Cherie Lucas, Walter Kmet, Shalom I Benrimoj, Kylie Williams
Background Team based care has been used internationally to improve the delivery of best practice primary health care. The WentWest General Practice Pharmacist Project, involving the integration of pharmacists within general practice teams, was commissioned to improve medication management of general practice patients. A particular focus of the project was the performance of medication review to allow the detection and resolution of drug related problems (DRPs). Objective The objectives of this 6-month study (October 2016-March 2017) were to: (1) identify and classify the DRPs detected as a result of pharmacist activities within a general practice primary care setting...
March 14, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29522990/identification-of-a-unique-insertion-in-plant-organellar-dna-polymerases-responsible-for-5-drp-lyase-and-strand-displacement-activities-implications-for-base-excision-repair
#10
Carlos H Trasviña-Arenas, Noe Baruch-Torres, Francisco J Cordoba-Andrade, Víctor M Ayala-García, Paola L García-Medel, Corina Díaz-Quezada, Antolín Peralta-Castro, José Juan Ordaz-Ortiz, Luis G Brieba
Plant mitochondrial and chloroplast genomes encode essential proteins for oxidative phosphorylation and photosynthesis. For proper cellular function, plant organelles must ensure genome integrity. Although plant organelles repair damaged DNA using the multi-enzyme Base Excision Repair (BER) pathway, the details of this pathway in plant organelles are largely unknown. The initial enzymatic steps in BER produce a 5'-deoxyribose phosphate (5'-dRP) moiety that must be removed to allow DNA ligation and in plant organelles, the enzymes responsible for the removal of a 5'-dRP group are unknown...
February 27, 2018: DNA Repair
https://www.readbyqxmd.com/read/29511437/mdivi-1-pretreatment-mitigates-isoflurane-induced-cognitive-deficits-in-developmental-rats
#11
Jie Gao, Ailin Luo, Jing Yan, Xi Fang, Xiaole Tang, Yilin Zhao, Shiyong Li
Accumulating evidence indicates that general anesthetics can cause acute neuroapoptosis and long-term cognitive deficit in models exposed to anesthetics during the brain growth-spurt period. Anesthetics-induced imbalance of mitochondrial fusion and fission preceded and contributed to developmental neuroapoptosis. Accordingly, the imbalance was accompanied by activation of dynamin-related protein (Drp)1 which was closely associated with synaptic degeneration in neurodegenerative diseases. Based on the neuroprotective role of mitochondrial division inhibitor-1 (mdivi-1) in neurodegeneration and stroke, we set out to examine whether mdivi-1 can mitigate developmental neurotoxicity induced by isoflurane...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29501869/pravastatin-improves-risk-factors-but-not-ischaemic-tolerance-in-obese-rats
#12
Massa Oi, Daniel Donner, Jason Peart, Belinda Beck, Lauren Wendt, John P Headrick, Eugene F du Toit
Statins are effective in management of dyslipidaemia, and a cornerstone of CVD prevention strategies. However, the impacts of their pleiotropic effects on other cardiovascular risk factors and myocardial responses to infarction are not well characterised. We hypothesised that pravastatin treatment in obesity improves lipid profiles, insulin-resistance and myocardial resistance to ischaemia/reperfusion (I/R) injury. Wistar rats were fed a control (C) chow or high carbohydrate and fat diet (HCFD) for 16 weeks with vehicle or pravastatin (prava 7...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29488017/network-analysis-of-drug-related-problems-in-hospitalized-patients-with-hematologic-malignancies
#13
Myeong Gyu Kim, Chae Reen Jeong, Hyun Jee Kim, Jae Hyun Kim, Yun-Kyoung Song, Kyung Im Kim, Eunhee Ji, Sung-Soo Yoon, Youngil Koh, Yoon-Sook Cho, In-Wha Kim, Jung Mi Oh
PURPOSE: Network analysis was conducted to systematically analyze the relationship between causative drugs and types of drug-related problems (DRPs) in hospitalized patients with hematologic malignancies. METHODS: A total of 1187 DRPs identified in hematology wards between 2013 and 2015 were analyzed. DRPs were classified into 11 sub-domains for problems and 35 sub-domains for causes according to Pharmaceutical Care Network Europe classification. Causative drugs were classified by Anatomical Therapeutic Chemical code...
February 27, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29486702/y-box-binding-protein-1-stimulates-abasic-site-cleavage
#14
E E Alemasova, K N Naumenko, N A Moor, O I Lavrik
Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5' side of the AP site, thereby generating a single-strand DNA break flanked by the 3'-OH and 5'-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs...
December 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29477279/-clinical-pharmacist-and-medication-reconciliation-in-kidney-transplantation
#15
Fabienne Flamme-Obry, Stéphanie Belaiche, Marc Hazzan, Nassima Ramdan, Christian Noël, Pascal Odou, Bertrand Décaudin
INTRODUCTION: Drug related problems (DRP) can lead to severe consequences in kidney recipients. The aim of the study was to assess the impact of the clinical pharmacist interventions on the incidence of DRP. METHOD: The number of DRP were evaluated according to 3periods: Without intervention, with medication reconciliation at admission, and with medication reconciliation at admission associated with an interview with the clinical pharmacist at discharge. RESULTS: Patients concerned were mainly men, 55years old (median age), stage3 of CKD, transplanted for less than 3months or more than 1year, with cardiovascular risk factors and receiving an average of 9drugs/day...
February 21, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29462705/nitric-oxide-and-mitochondrial-function-in-neurological-diseases
#16
REVIEW
Mehdi Ghasemi, Yunis Mayasi, Anas Hannoun, Seyed Majid Eslami, Raphael Carandang
Mitochondria are key cellular organelles that play crucial roles in the energy production and regulation of cellular metabolism. Accumulating evidence suggests that mitochondrial activity can be modulated by nitric oxide (NO). As a key neurotransmitter in biologic systems, NO mediates the majority of its function through activation of the cyclic guanylyl cyclase (cGC) signaling pathway and S-nitrosylation of a variety of proteins involved in cellular functioning including those involved in mitochondrial biology...
February 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/29429957/a-non-apoptotic-function-of-mcl-1-in-promoting-pluripotency-and-modulating-mitochondrial-dynamics-in-stem-cells
#17
Megan L Rasmussen, Leigh A Kline, Kyungho P Park, Natalya A Ortolano, Alejandra I Romero-Morales, Christin C Anthony, Kathryn E Beckermann, Vivian Gama
Human pluripotent stem cells (hPSCs) maintain a highly fragmented mitochondrial network, but the mechanisms regulating this phenotype remain unknown. Here, we describe a non-cell death function of the anti-apoptotic protein, MCL-1, in regulating mitochondrial dynamics and promoting pluripotency of stem cells. MCL-1 is induced upon reprogramming, and its inhibition or knockdown induces dramatic changes to the mitochondrial network as well as loss of the key pluripotency transcription factors, NANOG and OCT4...
March 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29421824/the-main-determinants-of-serum-resistin-level-in-type-2-diabetic-patients-are-renal-function-and-inflammation-not-presence-of-microvascular-complication-obesity-and-insulin-resistance
#18
Egemen Cebeci, Cengiz Cakan, Meltem Gursu, Sami Uzun, Serhat Karadag, Macit Koldas, Turan Calhan, Serife Aysen Helvaci, Savas Ozturk
AIM: The association of increased resistin levels in chronic kidney disease with diabetic nephropathy has not yet been clarified. Our aim was to analyze the relationship between serum resistin levels and various diabetic microvascular complications in patients. METHODS: A total of 83 patients were enrolled in this cross-sectional study. The subjects were divided into 3 groups: 27 patients with type 2 diabetes mellitus (T2DM) having no diabetic retinopathy (DRP) or microalbuminuria and having normal renal function were included in Group-1, 28 patients with T2DM having DRP and normal renal function in Group-2, and 28 patients with T2DM with DRP and microalbuminuria and an estimated glomerular filtration rate (eGFR) of<60 ml/min/1...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29419407/hyperoxia-causes-mitochondrial-fragmentation-in-pulmonary-endothelial-cells-by-increasing-expression-of-pro-fission-proteins
#19
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29414102/drp-1-dependent-mitochondrial-fragmentation-and-protective-autophagy-in-dopaminergic-sh-sy5y-cells-overexpressing-alpha-synuclein
#20
Jimena Hebe Martinez, Agustina Alaimo, Roxana Mayra Gorojod, Soledad Porte Alcon, Federico Fuentes, Federico Coluccio Leskow, Mónica Lidia Kotler
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the Lewy bodies. Additional common features of this disease are the mitochondrial dysfunction and the activation/inhibition of autophagy both events associated to the intracellular accumulation of α-synuclein. The mechanism by which these events contribute to neural degeneration remains unknown...
January 27, 2018: Molecular and Cellular Neurosciences
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