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Aspiration pneumonia

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https://www.readbyqxmd.com/read/29790300/aspiration-pneumonia-induces-muscle-atrophy-in-the-respiratory-skeletal-and-swallowing-systems
#1
Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose
BACKGROUND: Repetition of the onset of aspiration pneumonia in aged patients is common and causes chronic inflammation. The inflammation induces proinflammatory cytokine production and atrophy in the muscles. The proinflammatory cytokines induce muscle proteolysis by activating calpains and caspase-3, followed by further degradation by the ubiquitin-proteasome system. Autophagy is another pathway of muscle atrophy. However, little is known about the relationship between aspiration pneumonia and muscle...
May 22, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29788321/presentation-of-oropharyngeal-dysphagia-and-rehabilitative-intervention-following-esophagectomy-a-systematic-review
#2
A Kaneoka, S Yang, H Inokuchi, R Ueha, H Yamashita, T Nito, Y Seto, N Haga
No study has systematically reviewed the evidence on presentation of oropharyngeal dysphagia and swallowing rehabilitation following esophagectomy. The purposes of this systematic review are to 1) qualitatively synthesize the current findings on oropharyngeal swallowing abnormalities identified by instrumental swallowing evaluations, 2) describe the reported health-related outcomes in relation to swallowing abnormality following esophagectomy, and 3) examine the efficacy of reported rehabilitative interventions for oropharyngeal dysphagia in patients who underwent esophagectomy...
May 21, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29781209/oral-phase-dysphagia-in-facial-onset-sensory-and-motor-neuronopathy
#3
Mitsuru Watanabe, Wataru Shiraishi, Ryo Yamasaki, Noriko Isobe, Motohiro Sawatsubashi, Ryuji Yasumatsu, Takashi Nakagawa, Jun-Ichi Kira
INTRODUCTION: Facial onset motor and sensory neuronopathy (FOSMN) is a rare disease whose cardinal features are initial asymmetrical facial sensory deficits followed by bulbar symptoms and spreading of sensory and motor deficits from face to scalp, neck, upper trunk, and upper extremities in a rostral-caudal direction. Although bulbar involvement is frequently observed in FOSMN, dysphagia in these patients has not been fully described. In this study, we aimed to characterize dysphagia as a prognostic factor in FOSMN by investigating our institutional case series...
May 21, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29780243/effect-of-starting-oral-intake-on-weekends-on-the-clinical-course-of-patients-with-aspiration-pneumonia
#4
Tsuneaki Kenzaka, Ayako Kumabe, Koki Kosami, Yuki Ueda, Takeshi Takahashi, Yuya Yamamoto, Yurika Hayashi, Akihito Kitao, Masanobu Okayama
Purpose: The aim of this study was to investigate whether the day of starting oral intake affects the clinical course of patients with aspiration pneumonia. Results: We conducted a retrospective cohort study of 392 patients who were hospitalized for aspiration pneumonia but tolerated oral intake. Patients were divided into two groups according to the day of starting oral intake: Monday to Friday (midweek group) and Saturday or Sunday (weekend group). Underlying diseases, severity of pneumonia, time to oral intake, hospital duration, discontinuation of oral intake, and death during hospitalization were compared between the groups...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29779602/swallowing-and-secretion-management-in-neuromuscular-disease
#5
REVIEW
Deanna Britton, Chafic Karam, Joshua S Schindler
Neuromuscular disease frequently leads to dysphagia and difficulty managing secretions. Dysphagia may lead to medical complications, such as malnutrition, dehydration, aspiration pneumonia, and other pulmonary complications, as well as social isolation and reduced overall quality of life. This review provides an overview of dysphagia associated with neuromuscular disease in adults, along with a concise review of swallowing assessment and intervention options.
June 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29774151/gastrointestinal-endoscopy-under-sedation-is-associated-with-pneumonia-in-older-inpatients-results-of-a-retrospective-case-control-study
#6
Christopher M Kollmann, Wolff Schmiegel, Thorsten Brechmann
Background and aims: Apparent aspiration is a notable adverse event during gastrointestinal endoscopy under sedation (GIES), but data about inapparent aspiration are scarce. Generally, particularly older patients are at higher risk of suffering from adverse events. Objective: The objective of this article is to determine the risk of pneumonia, lower respiratory tract infection (LRI) and systemic inflammatory activation after GIES, especially in patients of at least 65 years...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29768382/transbronchial-drainage-using-endobronchial-ultrasonography-with-guide-sheath-for-lung-abscess-a-case-report
#7
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
RATIONALE: Lung abscess was previously treated surgically, but is now mainly treated with antibiotics and ideally with direct drainage, although postural drainage canalso be used. PATIENT CONCERNS: A chest abnormal shadow was detected in an 82-year-old man and he was referred to our department in November 2017. On chest computed tomography (CT), a low-density mass shadow was present in the left S8 segment. Lung abscess and lung cancer were considered as differential diagnoses, and treatment with sulbactam sodium/ampicillin sodium (SBT/ABPC) was first initiated for lung abscess...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766275/implementing-cough-reflex-testing-in-a-clinical-pathway-for-acute-stroke-a-pragmatic-randomised-controlled-trial
#8
Makaela Field, Rachel Wenke, Arman Sabet, Melissa Lawrie, Elizabeth Cardell
Silent aspiration is common after stroke and can lead to subsequent pneumonia. While standard bedside dysphagia assessments are ineffective at predicting silent aspiration, cough reflex testing (CRT) has shown promise for identifying patients at risk of silent aspiration. We investigated the impact of CRT on patient and service outcomes when embedded into a clinical pathway. 488 acute stoke patients were randomly allocated to receive either CRT or standard care (i.e. bedside assessment). Primary outcomes included confirmed pneumonia within 3 months post stroke and length of acute inpatient stay...
May 15, 2018: Dysphagia
https://www.readbyqxmd.com/read/29764621/erratum-to-the-possible-protective-role-of-pumpkin-seed-oil-in-an-animal-model-of-acid-aspiration-pneumonia-light-and-electron-microscopic-study-acta-histochemica-119-2017-161-171
#9
https://www.readbyqxmd.com/read/29759083/hypertrophic-osteoarthropathy-mimicking-a-reactive-arthritis-a-case-report-and-review-of-the-literature
#10
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti
BACKGROUND: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. CASE PRESENTATION: A 77-year-old man presented with fever, diarrhea, and an oligoarthritis involving the left knee and the ankles...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29755101/-outcome-of-surgical-treatment-of-locally-advanced-lung-cancer-after-induction-chemoradiotherapy
#11
Masayuki Tanahashi, Haruhiro Yukiue, Eriko Suzuki, Naoko Yoshii, Shinsuke Kitazawa, Yasunori Kaminuma, Hiroshi Niwa
OBJECTIVE: The outcome of surgical treatment of non-small-cell lung cancer after induction chemoradiotherapy was investigated. SUBJECTS: The subjects were 74 patients with non-small-cell lung cancer who received induction chemoradiotherapy( ICRT) between 1998 and 2016. ICRT was administered to pT3 lung cancer invading the chest wall(20 patients), pT4 lung cancer invading the adjacent organ(22 patients), and cN2 lung cancer(32 patients). cN2 was confirmed by mediastinoscopy(13 patients) and endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)(19 patients)...
April 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753296/mortality-specific-comorbidity-among-inpatients-with-epilepsy-a-preliminary-cross-sectional-study-in-west-china
#12
Yang Si, Xiaoqiang Xiao, Hongbin Sun
PURPOSE: The purpose of this study was to investigate the current condition of mortality-specific comorbidity among hospitalized patients with epilepsy (PWE). METHODS: The discharge abstract records of PWE from over 730,000 admissions were extracted from the hospital medical database. Fourteen mortality-related comorbidities from an epilepsy-specific index (ESI) were selected for the present assessment. The hospital-based prevalence of these comorbidities was estimated...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29752554/secondary-hypogammaglobulinemia-after-rituximab-for-neuromyelitis-optica-a-case-report
#13
Lara Farhat, Jasmeen Dara, Susan Duberstein, Aliva De
A 17-year-old male with history of neuromyelitis optica and seizures presented to the pulmonology clinic for evaluation of recurrent pneumonias. He had received rituximab for the past 6 years. Over the past 2 years, he experienced four episodes of pneumonia. In between these episodes, he would improve briefly but continued to have daily cough that was productive with yellow phlegm. He also had recurrent rhinitis and sinusitis despite multiple antibiotic courses. Review of chest X-rays revealed localized right middle lobe and right lower lobe infiltrates...
May 11, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29751747/a-fatal-case-associated-with-respiratory-syncytial-virus-infection-in-a-young-child
#14
Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian, Zhengde Xie
BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old...
May 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29749062/impact-of-stroke-associated-pneumonia-on-mortality-length-of-hospitalization-and-functional-outcome
#15
W H Teh, C J Smith, R S Barlas, A D Wood, J H Bettencourt-Silva, A B Clark, A K Metcalf, K M Bowles, J F Potter, P K Myint
OBJECTIVES: Stroke-associated pneumonia (SAP) is common and associated with adverse outcomes. Data on its impact beyond 1 year are scarce. MATERIALS AND METHODS: This observational study was conducted in a cohort of stroke patients admitted consecutively to a tertiary referral center in the east of England, UK (January 2003-April 2015). Logistic regression models examined inpatient mortality and length of stay (LOS). Cox regression models examined longer-term mortality at predefined time periods (0-90 days, 90 days-1 year, 1-3 years, and 3-10 years) for SAP...
May 10, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29743455/-evaluation-of-the-safety-and-efficacy-of-endoscopic-treatment-for-early-gastric-cancers-in-patients-aged-over-80-years
#16
Takeshi Setoyama, Shin' Ichi Miyamoto, Mitsuhiro Nikaido, Takahiro Horimatsu, Shigemi Matsumoto, Yasumasa Ezoe, Shuko Morita, Ikuo Aoyama, Chiharu Kawanami, Toshihiro Kusaka, Tsutomu Chiba, Manabu Muto, Hiroshi Seno
Endoscopic treatments, including endoscopic mucosal resection or endoscopic submucosal dissection, are well accepted as standard treatments for early gastric cancers. However, there are few studies evaluating the safety and efficacy of this approach for early gastric cancers in patients aged over 80 years, and the post-treatment prognosis remains unclear. Here, we retrospectively analyzed the medical records and evaluated the safety and efficacy of endoscopic treatment for early gastric cancers in patients aged over 80 years (group A) compared with non-elderly patients aged 65-79 years (group B) and under 65 years (group C)...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29740589/cervical-hyperostosis-leading-to-dyspnea-aspiration-and-dysphagia-strategies-to-improve-patient-management
#17
Georgios Psychogios, Monika Jering, Johannes Zenk
Diffuse idiopathic skeletal hyperostosis (DISH) is a rare but well known cause of dysphagia. In very few cases aspiration and dyspnea are described as a clinical manifestation. An 82-year-old man presented himself in our clinic with severe dyspnea, aspiration, and pneumonia. After performing a microlaryngoscopy an emergency tracheotomy became necessary. In laryngoscopy a severe bulging of the posterior oropharyngeal and hypopharyngeal wall was detected. The glottis area was not observable and immobilisation of the right vocal cord could be detected...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29730088/aspiration-pneumonia-and-related-syndromes
#18
REVIEW
Augustine S Lee, Jay H Ryu
Aspiration is a syndrome with variable respiratory manifestations that span acute, life-threatening illnesses, such as acute respiratory distress syndrome, to chronic, sometimes insidious, respiratory disorders such as aspiration bronchiolitis. Diagnostic testing is limited by the insensitivity of histologic testing, and although gastric biomarkers for aspiration are increasingly available, none have been clinically validated. The leading mechanism for microaspiration is thought to be gastroesophageal reflux disease, largely driven by the increased prevalence of gastroesophageal reflux across a variety of respiratory disorders, including chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and chronic cough...
May 2, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29721820/hypothermic-total-liquid-ventilation-after-experimental-aspiration-associated-acute-respiratory-distress-syndrome
#19
Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier
BACKGROUND: Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective was to determine whether hypothermic TLV could be safe or even beneficial in an aspiration-associated ARDS animal model...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29717284/antibiotic-susceptibility-pattern-of-gram-negative-isolates-of-lower-respiratory-tract-infection
#20
Rakshya Nepal, Basudha Shrestha, Deepak Man Joshi, Rajesh Dhoj Joshi, Sanjit Shrestha, Anjana Singh
BACKGROUND: Lower respiratory tract infection is a common cause of morbidity and mortality worldwide. A cross-sectional study was carried out with an objective to study the antibiogram of Gram-negative isolates of patients with lower respiratory tract infection visiting Kathmandu Model Hospital. METHODS: A total of 274 specimens including sputum, endotracheal aspirates, suction tips were cultured as per standard microbiological technique. Antibiotic susceptibility and detection of Extended-spectrum beta- lactamases (ESBLs) were performed following Clinical Laboratory Standard Institute (CLSI 2014) guidelines...
March 13, 2018: Journal of Nepal Health Research Council
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