Barry Buckland, Gautam Sanyal, Todd Ranheim, David Pollard, Jim A Searles, Sue Behrens, Stefanie Pluschkell, Jessica Josefsberg, Christopher J Roberts
In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID-19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors. Improvements in the analytical toolbox, equipment, and bioprocess technology have made it possible to achieve both unprecedented speed in vaccine development and scale of vaccine manufacturing. Macromolecular structure-function characterization technologies, combined with improved modeling and data analysis, enable quantitative evaluation of vaccine formulations at single-particle resolution and guided design of vaccine drug substances and drug products...
May 6, 2024: Biotechnology and Bioengineering