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Analytical Techniques

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https://www.readbyqxmd.com/read/28732345/multichannel-electroanalytical-devices-for-competitive-elisa-of-phenylethanolamine-a
#1
Yang Liu, Meng Cai, Weiping Wu, Yuting Fang, Pei She, Shouming Xu, Jianguo Li, Kang Zhao, Jingjuan Xu, Ning Bao, Anping Deng
Herein, we reported a disposable electroanalytical device for competitive enzyme-linked immunosorbent assay (ELISA) of phenylethanolamine A (PA). Conductive carbon tape coated with gold cluster served as the working electrode, while the counter and reference electrodes were fabricated on the filter paper by the screen-printing technique. Separating fabrication of the working electrode from other electrodes could make it possible for full utilization of the working electrode modification in bulk and no contamination of the immune-reagents on the counter and reference electrodes...
April 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28732276/sampling-and-single-particle-analysis-for-the-chemical-characterisation-of-fine-atmospheric-particulates-a-review
#2
REVIEW
Michele Elmes, Massimo Gasparon
To better understand the potential environmental and human health impacts of fine airborne particulate matter (APM), detailed physical and chemical characterisation is required. The only means to accurately distinguish between the multiple compositions in APM is by single particle analysis. A variety of methods and instruments are available, which range from filter-based sample collection for off-line laboratory analysis to on-line instruments that detect the airborne particles and generate size distribution and chemical data in real time...
July 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28732242/the-depression-and-marital-status-relationship-is-modified-by-both-age-and-gender
#3
Andrew G M Bulloch, Jeanne V A Williams, Dina H Lavorato, Scott B Patten
BACKGROUND: Marital status is associated with major depression prevalence, however, the strength of association may be modified by age and gender. METHODS: The data sources were a series of cross sectional national health surveys of the Canadian population carried out by Statistics Canada during 1996-2013. These were cross-sectional files from the National Population Health Survey of 1996, together with the Canadian Community Health Surveys from 2000 to 2013; the respondents were 18 years and older...
July 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28731349/improved-metrological-traceability-of-particle-size-values-measured-with-line-start-incremental-centrifugal-liquid-sedimentation
#4
Vikram Kestens, Victoria A Coleman, Pieter-Jan De Temmerman, Caterina Minelli, Holger Woehlecke, Gert Roebben
Line-start incremental centrifugal liquid sedimentation (disc-CLS) is a powerful method to determine particle size. It is based on Stokes' law and on the measurement of particle sedimentation rate through a liquid with a density gradient. Because several of the input quantities of the Stokes' equation cannot be easily determined for this case of a rotating disc, the usual disc-CLS approach relies on calibrating the sedimentation time scale with commercially available PVC reference particles. To use these calibrant particles for establishing metrological traceability, they must fulfil the same requirements as those imposed on a certified reference material, i...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730988/radiostereometric-analysis-of-keeled-versus-pegged-glenoid-components-in-total-shoulder-arthroplasty-a-randomized-feasibility-study
#5
Trevor C Gascoyne, Sheila M B McRae, Sara L Parashin, Jeff R S Leiter, Martin J Petrak, Eric R Bohm, Peter B MacDonald
BACKGROUND: This study aimed to assess differences in the fixation and functional outcomes between pegged and keeled all-polyethylene glenoid components for standard total shoulder arthroplasty. METHODS: Patients were randomized to receive a keeled or pegged all-polyethylene glenoid component. We used model-based radiostereometric analysis (RSA) to assess glenoid fixation and subjective outcome measures to assess patient function. Follow-up examinations were completed at 6 weeks and 6, 12 and 24 months after surgery...
August 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28730493/magnetic-resonance-spectroscopy-mrs-based-methods-for-examining-cancer-metabolism-in-response-to-oncogenic-kinase-drug-treatment
#6
Yuen-Li Chung
Magnetic resonance spectroscopy (MRS) is an analytical technique that has been extensively used to examine reprogrammed metabolism and treatment response in cancer cells and solid tumors both in vivo and ex vivo. High-resolution MRS (HR-MRS) is one of the best methods for metabolic profiling, as it is highly quantitative, robust, and reproducible. The protocols for dual-phase extraction of cancer cells and tumors and sample preparations for high-resolution (1)H and (31)P HR-MRS analysis are described here. Descriptions of spectra acquisition and analysis are also included in this chapter...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730481/label-free-phosphoproteomic-approach-for-kinase-signaling-analysis
#7
Edmund Wilkes, Pedro R Cutillas
Phosphoproteomics is a powerful platform for the unbiased profiling of kinase-driven signaling pathways. Quantitation of phosphorylation can be performed by means of either labeling or label-free mass spectrometry (MS) methods. Because of their simplicity and universality, label-free methodology is gaining acceptance and popularity in molecular biology research. Analytical workflows for label-free quantification of phosphorylation, however, need to overcome several hurdles for the technique to be accurate and precise...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730308/tlc-surface-integrity-affects-the-detection-of-alkali-adduct-ions-in-tlc-maldi-analysis
#8
Yonghui Dong, Ruggero Ferrazza, Andrea Anesi, Graziano Guella, Pietro Franceschi
Direct coupling of thin-layer chromatography (TLC) with matrix-assisted laser desorption ionization (MALDI) mass spectrometry allows fast and detailed characterization of a large variety of analytes. The use of this technique, however, presents great challenges in semiquantitative applications because of the complex phenomena occurring at the TLC surface. In our laboratory, we recently observed that the ion intensities of several alkali adduct ions were significantly different between the top and interior layer of the TLC plate...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28730194/covalent-hybrids-based-on-re-i-tricarbonyl-complexes-and-polypyridine-functionalized-polyoxometalate-synthesis-characterization-and-electronic-properties
#9
Thomas Auvray, Marie-Pierre Santoni, Bernold Hasenknopf, Garry S Hanan
A series of [Re(CO)3Br(N^N)] (N^N = substituted 2,2'-bipyridine ligand) complexes based on polypyridine-functionalized Dawson polyoxometalate (1-3) has been synthesized. The new hybrids (4-6) were characterized by various analytical techniques, including absorption, vibrational and luminescence spectroscopies as well as electrochemistry. Both units, the polyoxometalate and the transition metal complex, retain their intrinsic properties. Their combination in the newly prepared hybrids results in improved photosensitization in the high-energy visible region...
July 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28729560/adaptive-control-of-ion-yield-in-femtosecond-laser-post-ionization-for-secondary-ion-mass-spectrometry
#10
Dusan Lorenc, Monika Jerigova, Monika Stupavska, Dusan Velic
Secondary ion mass spectrometry is an excellent technique of analytical chemistry, where primary ions sputter a solid sample generating the secondary ions which are determined. Although the ion yield is inherently low, it can be enhanced by using a post-ionization of sputtered neutral species. Our novel approach integrates this technique with a near infrared femtosecond laser post-ionization based on an adaptive control through a laser pulse shaper. The shaping of the laser pulse provides adaptive control to select a mass peak of interest and to enhance this peak intensity...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728929/an-evaporation-assisted-dispersive-liquid-liquid-microextraction-technique-as-a-simple-tool-for-high-performance-liquid-chromatography-tandem-mass-spectrometry-determination-of-insecticides-in-wine
#11
Irina Timofeeva, Daria Kanashina, Leonid Moskvin, Andrey Bulatov
A sample pre-treatment technique based on evaporation-assisted dispersive liquid-liquid microextraction (EVA-DLLME), followed by HPLC-MS/MS has been developed for the determination of organophosphate insecticides (malathion, diazinon, phosalone) in wine samples. The procedure includes the addition of mixture of organic solvents (with density higher than water), consisting of the extraction (low density) and volatile (high density) solvents, to aqueous sample followed by heating of the mixture obtained, what promotes the volatile solvent evaporation and moving extraction solvent droplets from down to top of the aqueous sample and, as a consequence, microextraction of target analytes...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28728577/integrating-data-from-randomized-controlled-trials-and-observational-studies-to-predict-the-response-to-pregabalin-in-patients-with-painful-diabetic-peripheral-neuropathy
#12
Joe Alexander, Roger A Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky, Bruce Parsons
BACKGROUND: More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different types of studies, such as randomized controlled trials (RCTs) and observational studies. Given the importance of evidence from both types of studies, our goal was to integrate these types of data into a single predictive platform to help predict response to pregabalin in individual patients with painful diabetic peripheral neuropathy (pDPN)...
July 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28726388/detection-of-pesticide-residues-in-food-using-surface-enhanced-raman-spectroscopy-a-review
#13
Menglei Xu, Yu Gao, Xiao Xia Han, Bing Zhao
Pesticides directly pollute the environment and contaminate foods ultimately being absorbed by the human body. Their residues contain highly toxic substances that have been found to cause serious problems to human health even at very low concentrations. The gold standard method, gas/liquid chromatography combined with mass spectroscopy, has been widely used for the detection of pesticide residues. However, these methods have some drawbacks such as complicated pre-treatment and cleanup steps. Recent technological advancements of surface-enhanced Raman spectroscopy (SERS) has promoted the creation of alternative detection techniques...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726383/marangoni-convection-assisted-single-molecule-detection-with-nanojet-surface-enhanced-raman-spectroscopy
#14
Te-Wei Chang, Xinhao Wang, Amirreza Mahigir, Georgios Veronis, Gang Logan Liu, Manas Ranjan Gartia
Many single-molecule (SM) label-free techniques such as scanning probe microscopies (SPM) and magnetic force spectroscopies (MFS) provide high resolution surface topography information, but lack chemical information. Typical surface enhanced Raman spectroscopy (SERS) systems provide chemical information on the analytes, but lack spatial resolution. In addition, a challenge in SERS sensors is to bring analytes into the so-called "hot spots" (locations where the enhancement of electromagnetic field amplitude is larger than 10(3))...
July 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28725632/medicinal-importance-pharmacological-activities-and-analytical-aspects-of-hispidulin-a-concise-report
#15
REVIEW
Kanika Patel, Dinesh Kumar Patel
Herbal medicines have been played an important role in the human civilization since very ancient time as a food, cloth, medicine and other aspects. Some of the important drugs in the modern medicine were derived from the natural sources such as aspirin, digitalis, quinine, vincristine, vinblastine etc. Hispidulin (4', 5, 7-trihydroxy-6-methoxyflavone) is a flavones derivative found in plant such as Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia and Salvia species...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#16
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28724346/biosensing-technologies-for-therapeutic-drug-monitoring
#17
Anna Meneghello, Stefano Tartaggia, Maria Domenica Alvau, Federico Polo, Giuseppe Toffoli
Therapeutic drug monitoring (TDM) is the clinical practice of measuring pharmaceutical drug concentrations in patients' biofluids at designated intervals to allow a close and timely control of their dosage. This practice allows for rapid medical intervention in case of toxicity-related issues and/or adjustment of dosage to better fit the therapeutic demand. Currently, TDM is performed in centralized laboratories employing instruments, such as immunoassay analyzers and mass spectrometers that can be run only by trained personnel...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28723211/improving-fore-a-new-inlet-design-for-filtering-samples-through-individual-microarray-spots
#18
Victoria de Lange, Marco Habegger, Marco Schmidt, János Vörös
In this publication we present an improvement to our previously introduced vertical flow microarray, the FoRe array, which capitalizes on the fusion of immunofiltration and densely packed micron test sites. Filtering samples through individual microarray spots allows us to rapidly analyze dilute samples with high-throughput and high signal-to-noise. Unlike other flowthrough microarrays, in the FoRe design samples are injected into micron channels and sequentially exposed to different targets. This arrangement makes it possible to increase the sensitivity of the microarray by simply increasing the sample volume or to rapidly reconcentrate samples after preprocessing steps dilute the analyte...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723189/ionophore-based-titrimetric-detection-of-alkali-metal-ions-in-serum
#19
Jingying Zhai, Xiaojiang Xie, Thomas Cherubini, Eric Bakker
While the titrimetric assay is one of the most precise analytical techniques available, only a limited list of complexometric chelators is available, as many otherwise promising reagents are not water-soluble. Recent work demonstrated successful titrimetry with ion-exchanging polymeric nanospheres containing hydrophobic complexing agents, so-called ionophores, opening an exciting avenue in this field. However, this method was limited to ionophores of very high affinity to the analyte and exhibited a relatively limited titration capacity...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723149/cyclewise-operation-of-printed-mos2-transistor-biosensors-for-rapid-biomolecule-quantification-at-femtomolar-levels
#20
Byunghoon Ryu, Hongsuk Nam, Bo-Ram Oh, Yujing Song, Pengyu Chen, Younggeun Park, Wenjie Wan, Katsuo Kurabayashi, Xiaogan Liang
Field-effect transistors made from MoS2 and other emerging layered semiconductors have been demonstrated to be able to serve as ultrasensitive biosensors. However, such nanoelectronic sensors still suffer seriously from a series of challenges associated with the poor compatibility between electronic structures and liquid analytes. These challenges hinder the practical biosensing applications that demand rapid, low-noise, highly specific biomolecule quantification at femtomolar levels. To address such challenges, we study a cyclewise process for operating MoS2 transistor biosensors, in which a series of reagent fluids are delivered to the sensor in a time-sequenced manner and periodically set the sensor into four assay-cycle stages, including incubation, flushing, drying, and electrical measurement...
February 24, 2017: ACS Sensors
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