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https://www.readbyqxmd.com/read/28215802/occurrence-of-halogenated-and-organophosphate-flame-retardants-in-sediment-and-fish-samples-from-three-european-river-basins
#1
Monica Giulivo, Ettore Capri, Eleni Kalogianni, Radmila Milacic, Bruno Majone, Federico Ferrari, Ethel Eljarrat, Damià Barceló
Classic (polybromodiphenyl ethers, PBDEs) and emerging halogenated flame retardants (HFRs) such as decabromodiphenyl ethane (DBDPE) and halogenated norbornenes, as well as organophosphate flame retardants (OPFRs) were analysed in 52 sediments and 27 fish samples from three European river basins, namely the Evrotas (Greece), the Adige (Italy) and the Sava (Slovenia, Croatia, Bosnia and Herzegovina and Serbia). This is the first time that FR levels have been reported in these three European river basins. The highest contamination was found in the Adige and Sava rivers, whereas lower values were obtained for the Evrotas...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28207572/cross-reactivity-of-chloroquine-and-hydroxychloroquine-with-dri-amphetamine-immunoassay
#2
Isabel Gomila, Loreto Quesada, Victoria López-Corominas, Julia Fernández, Miguel Ángel Servera, Laura Sahuquillo, Macarena Dastis, Albert Torrents, Bernardino Barceló
BACKGROUND: Chloroquine and hydroxychloroquine are medical drugs used to treat the chemoprophylaxis of malaria as well as a second-line anti-inflammatory drug. METHODS: We performed a study of cross-reactivity of chloroquine and hydroxychloroquine in the DRI Amphetamine Assay inspired by a case report of a self-ingestion of chloroquine following a family dispute, that involved the following: (a) an in vitro study with control samples of healthy subjects, (b) an in vivo study with samples of patients with rheumatoid arthritis, and (c) an evaluation of the cross-reactivity of chloroquine and hydroxychloroquine in three additional immunoassays...
February 14, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28202703/investigations-in-gabaa-receptor-antibody-associated-encephalitis
#3
Marianna Spatola, Mar Petit-Pedrol, Mateus Mistieri Simabukuro, Thaís Armangue, Fernanda J Castro, Maria I Barcelo Artigues, Maria R Julià Benique, Leslie Benson, Mark Gorman, Ana Felipe, Ruben L Caparó Oblitas, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis. METHODS: Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABAAR were determined using reported techniques. RESULTS: Patients' median age was 40.5 years (interquartile range 48...
February 15, 2017: Neurology
https://www.readbyqxmd.com/read/28202359/preliminary-assessment-on-the-bioaccessibility-of-contaminants-of-emerging-concern-in-raw-and-cooked-seafood
#4
Ricardo N Alves, Ana L Maulvault, Vera L Barbosa, Sara Cunha, Christiaan J A F Kwadijk, Diana Álvarez-Muñoz, Sara Rodríguez-Mozaz, Òscar Aznar-Alemany, Ethel Eljarrat, Damià Barceló, Margarita Fernandez-Tejedor, Alice Tediosi, António Marques
A preliminary assessment of the bioaccessibility of contaminants of emerging concern (CeCs), including perfluorinated compounds (PFCs; i.e. PFOS and PFUnA), brominated flame retardants (BFRs; i.e. BDE47, BDE100, α-HBCD) and pharmaceuticals and personal care products (PPCPs; i.e. venlafaxine, methylparaben and UV-filter OC) was performed in seafood species available in the European markets. Additionally, the effect of steaming on CeCs bioaccessibility was also investigated for the first time. Overall, steaming affected differentially contaminants' concentrations, for instance, decreasing PFOS levels in flounder, but increasing both BDE47 and BDE100...
February 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28201726/discontinuation-efficacy-and-safety-of-cholinesterase-inhibitors-for-alzheimer-s-disease-a-meta-analysis-and-meta-regression-of-44-randomized-clinical-trials-enrolling-16-245-patients
#5
Lídia Blanco-Silvente, Xavier Castells, Marc Saez, Maria Antònia Barceló, Josep Garre-Olmo, Joan Vilalta-Franch, Dolors Capellà
No abstract text is available yet for this article.
February 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28198553/treatment-of-septic-arthritis-of-the-coxofemoral-joint-in-12-foals
#6
F Barceló Oliver, T M Russell, K L Uprichard, K M Neil, P J Pollock
OBJECTIVE: To describe the clinical signs, surgical treatment, and outcome of septic arthritis of the coxofemoral joint in foals. STUDY DESIGN: Retrospective clinical study. SAMPLE POPULATION: Foals (n = 12) with confirmed sepsis of the coxofemoral joint. METHODS: Lameness was localized to the coxofemoral joint based on physical examination. Sepsis was confirmed by cytological analysis of synovial fluid obtained under ultrasonographic guidance, during general anesthesia or standing sedation...
February 15, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28190538/acute-intoxication-caused-by-synthetic-cannabinoids-5f-adb-and-mmb-2201-a-case-series
#7
Bernardino Barceló, Simona Pichini, Victoria López-Corominas, Isabel Gomila, Christopher Yates, Francesco Paolo Busardò, Manuela Pellegrini
Synthetic cannabinoids are relatively new substances of abuse. Recently, abuse of synthetic cannabinoids has been increasingly reported in the lay press and medical literature. When new compounds are introduced, their use is initially not restricted by prohibition therefore their consumption cannot be verified by standard drug tests. The use of these compounds among adolescents and young adults is constantly growing, making it important for emergency services to be familiar with the signs and symptoms of intoxication present...
February 2, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28187656/caddisflies-insecta-trichoptera-from-maranh%C3%A3-o-state-northeast-region-brazil-a-new-species-checklist-and-new-geographical-records
#8
Gleison Robson Desidério, Patrik Barcelos-Silva, Wagner Rafael M DE Souza, Ana Maria Pes, Carlos Augusto S DE Azevêdo
In order to improve knowledge of Trichoptera diversity in Northeast Region, Brazil, we present here the first checklist of caddisflies from Maranhão State with a description of a new species and geographical records for the Northeast Region and for all of Brazil. Collections were made in 16 sites distributed in three municipalities of Maranhão State. A total of 54 caddisflies species, 26 genera and 10 families were recorded, including one new species of Leptoceridae, Triplectides maranhensis sp. nov., which is described and illustrated...
January 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/28174566/application-of-a-dot-blot-hybridization-platform-to-assess-streptococcus-uberis-population-structure-in-dairy-herds
#9
Pedro Albuquerque, Niza Ribeiro, Alexandre Almeida, Irena Panschin, Afonso Porfirio, Marta Vales, Francisca Diniz, Helena Madeira, Fernando Tavares
Streptococcus uberis is considered one of the most important pathogens associated with bovine mastitis. While traditionally acknowledged as an environmental pathogen, S. uberis has been shown to adopt a contagious epidemiological pattern in several dairy herds. Since different control strategies are employed depending on the mode of transmission, in-depth studies of S. uberis populations are essential to determine the best practices to control this pathogen. In this work, we optimized and validated a dot blot platform, combined with automatic image analysis, to rapidly assess the population structure of infective S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28166653/oxidative-stress-and-inflammation-liver-responses-and-adaptations-to-acute-and-regular-exercise
#10
Rômulo Pillon Barcelos, Luiz Fernando Freire Royes, Javier Gonzalez-Gallego, Guilherme Bresciani
The liver is remarkably important during exercise outcomes due to its contribution to detoxification, synthesis and release of biomolecules, and energy supply to the exercising muscles. Recently, liver has been also shown to play an important role in redox status and inflammatory modulation during exercise. However, while several studies have described the adaptations of skeletal muscles to acute and chronic exercise, hepatic changes are still scarcely investigated. Indeed, acute intense exercise challenges the liver with increased reactive oxygen species (ROS) and inflammation onset, whereas regular training induces hepatic antioxidant and anti-inflammatory improvements...
February 6, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28135215/muscular-strength-adaptations-and-hormonal-responses-after-two-different-multiple-set-protocols-of-resistance-training-in-postmenopausal-women
#11
Paulo Ricardo P Nunes, Larissa C Barcelos, Anselmo A Oliveira, Roberto Furlanetto Júnior, Fernanda M Martins, Elizabete Ap M R Resende, Fábio L Orsatti
We studied the effects of two different resistance training (RT) multiple-set protocols (three and six sets) on muscle strength and basal hormones concentrations in postmenopausal women (PW). Thirty-four PW were randomly allocated into three groups: control (CT, n=12), low RT volume (LV = three sets for each exercise, n=10) and high RT volume (HV = six sets for each exercise, n=12). The LV and HV groups performed eight exercises of a total body RT protocol three times a week, at 70 % of one repetition maximum (1RM) for 16 weeks...
January 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28134728/marker-protein-expression-combined-with-expression-heterogeneity-is-a-powerful-indicator-of-malignancy-in-acral-lentiginous-melanomas
#12
Fernando Cintra Lopes Carapeto, Andréia Neves Comodo, Andressa Germano, Daiane Pereira Guimarães, Denise Barcelos, Mariana Fernandes, Gilles Landman
PATIENTS AND METHODS: Samples of acral lentiginous melanomas (ALMs) were obtained from the Department of Pathology at Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Demographic, clinical, and follow-up data were obtained from the charts of Hospital São Paulo. From 2 tissue microarrays containing 60 nevi and quadruplicate samples of ≥1.0-mm of 49 ALM, sections were stained to evaluate SCF, KIT, BRAF, CYCLIND1, MYC, and PTEN immunohistochemical protein expression...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28126361/antigen-specific-secretion-of-ifn%C3%AE-and-cxcl10-in-whole-blood-assay-detects-mycobacterium-leprae-infection-but-does-not-discriminate-asymptomatic-infection-from-symptomatic-leprosy
#13
Emerith Mayra Hungria, Aline Araújo Freitas, Maria Araci Andrade Pontes, Heitor Sá Gonçalves, Ana Lúcia Osório Maroccolo Sousa, Maurício Barcelos Costa, Mirian Lane Oliveira Rodrigues Castilho, Malcolm S Duthie, Mariane Martins Araújo Stefani
To advance toward a whole blood assay (WBA)-based test capable of facilitating the diagnosis of paucibacillary (PB) leprosy, we evaluated a prototype in-tube WBA using combinations of Mycobacterium leprae antigens. Blood was collected from newly diagnosed untreated PB (n=38), multibacillary (MB) (n=30), healthy household contacts (HHC) of MB (n=27), and endemic controls (n=61) residing in Goiânia and Fortaleza, Brazil. Blood was incubated with M. leprae cell sonicate, recombinant proteins (46f+LID-1; ML0276+LID-1), or controls (phosphate-buffered saline, phytohemagglutinin, M...
January 5, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28120987/synthesis-of-aminopyrazoles-from-sydnones-and-ynamides
#14
T Wezeman, J Comas-Barceló, M Nieger, J P A Harrity, S Bräse
Aminopyrazoles are prepared from readily accessible sydnones and sulfonyl ynamides using either a copper-mediated sydnone alkyne cycloaddition (CuSAC) or in situ generated strained cyclic ynamides.
January 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28119008/integrated-environmental-risk-assessment-of-chemical-pollution-in-a-mediterranean-floodplain-by-combining-chemical-and-biological-methods
#15
Claudia Rivetti, Jhon J López-Perea, Celia Laguna, Benjamín Piña, Rafael Mateo, Ethel Eljarrat, Damià Barceló, Carlos Barata
The Tablas de Daimiel National Park (TDNP) is a unique floodplain ecosystem in central Spain, serving as permanent resting and breeding areas for many waterbird species. In the last decades, this biodiversity hotspot has been severely endangered by poorly treated wastewater discharges from upstream urban communities arriving through its two major contributors, the Cigüela and Guadiana rivers. In this work, we analysed the potential risk of this constant input of micropollutants (estrogens, dioxin-like compounds and other endocrine disruptors) for the resident wildlife...
January 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28112415/relation-between-mast-cells-concentration-and-serotonin-expression-in-chagasic-megacolon-development
#16
Michelle Aparecida Ribeiro de Freitas, Nathália Segatto, Natália Tischler, Enio Chaves de Oliveira, Axel Brehmer, Alexandre Barcelos Morais da Silveira
Chagas' disease still reaching about 10 million people in the world. In South America, one of the most severe forms of this disease is the megacolon, characterized by severe constipation, dilated sigmoid colon and rectum and severe malnutrition. Previous data suggested that mast cells and serotonin (5-HT) expression could be involved in intestinal homeostasis control, avoiding the chagasic megacolon development. The aim at this study was to characterize the presence of mast cells and expression of serotonin in chagasic patients with and without megacolon and evaluate the relation between mast cells, serotonin and megacolon development...
January 23, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28105487/biotransformation-of-%C3%AE-and-%C3%AE-pinene-into-flavor-compounds
#17
REVIEW
Kele A C Vespermann, Bruno N Paulino, Mayara C S Barcelos, Marina G Pessôa, Glaucia M Pastore, Gustavo Molina
Products that bear the label "natural" have gained more attention in the marketplace. In this approach, the production of aroma compounds through biotransformation or bioconversion has been receiving more incentives in economic and research fields. Among the substrates used in these processes, terpenes can be highlighted for their versatility and low cost; some examples are limonene, α-pinene, and β-pinene. This work focused on the biotransformation of the two bicyclic monoterpenes, α-pinene and β-pinene; the use of different biocatalysts; the products obtained; and the conditions employed in the process...
January 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28104333/response-of-lemna-gibba-l-to-high-and-environmentally-relevant-concentrations-of-ibuprofen-removal-metabolism-and-morpho-physiological-traits-for-biomonitoring-of-emerging-contaminants
#18
D Di Baccio, F Pietrini, P Bertolotto, S Pérez, D Barcelò, M Zacchini, E Donati
The increasing worldwide consumption of pharmaceuticals and personal care products such as ibuprofen (IBU) is leading to the widespread and persistent occurrence of these chemicals and their transformation products in soils and waters. Although at low concentrations, the continuous discharge of these micropollutants and the incomplete removal by the actual wastewater treatments can provoke accumulation in the environment with risks for the trophic chain. Non-target organisms as duckweed can be used for the environmental monitoring of pharmaceutical emerging contaminants...
January 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28099969/digital-ischemia-as-a-paraneoplastic-phenomenon
#19
Tatiana Rodrigues, Anabela Barcelos
Digital ischemia is a rare paraneoplastic phenomenon associated with several malignant tumours, particularly adenocarcinomas. The underlying pathogenic mechanisms remain unknown and it can be the first manifestation, occur after the diagnosis or during treatment. We report a case of a 50 year old woman presenting with digital ischemia, whose diagnostic workup led to an invasive breast cancer, with significant improvement of digital ischemia after a successful treatment of the neoplasm.
October 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28078618/decreased-tap63-and-%C3%AE-np63-mrna-levels-in-most-human-pituitary-adenomas-are-correlated-with-notch3-jagged1-relative-expression
#20
Lisiane Cervieri Mezzomo, Frederico Giacomoni Pesce, Josenel Maria Barcelos Marçal, Taiana Haag, Nelson Pires Ferreira, Julia Fernanda Semmelmann Pereira Lima, Carolina Garcia Soares Leães, Miriam Costa Oliveira, Maria Beatriz da Fonte Kohek
Despite recent advances in molecular genetics, the pituitary adenoma initiation, development, progress, and the molecular basis of their unique features are still poorly understood. In this sense, it is proposed that stem cell could be involved in pituitary adenoma tumorigenesis. It is suggested that TP63 has important functions in stem cells, and it may have interplay of TP63 and Notch and its ligand Jagged in this process. This study aimed to evaluate the distinct expression of TP63 isoforms (TAp63 and ΔNp63), as well as its correlation with Notch3 receptor and its ligand Jagged1 in human pituitary adenomas at the messenger RNA (mRNA) level...
January 11, 2017: Endocrine Pathology
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