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https://www.readbyqxmd.com/read/28099969/digital-ischemia-as-a-paraneoplastic-phenomenon
#1
Tatiana Rodrigues, Anabela Barcelos
Digital ischemia is a rare paraneoplastic phenomenon associated with several malignant tumours, particularly adenocarcinomas. The underlying pathogenic mechanisms remain unknown and it can be the first manifestation, occur after the diagnosis or during treatment. We report a case of a 50 year old woman presenting with digital ischemia, whose diagnostic workup led to an invasive breast cancer, with significant improvement of digital ischemia after a successful treatment of the neoplasm.
October 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28078618/decreased-tap63-and-%C3%AE-np63-mrna-levels-in-most-human-pituitary-adenomas-are-correlated-with-notch3-jagged1-relative-expression
#2
Lisiane Cervieri Mezzomo, Frederico Giacomoni Pesce, Josenel Maria Barcelos Marçal, Taiana Haag, Nelson Pires Ferreira, Julia Fernanda Semmelmann Pereira Lima, Carolina Garcia Soares Leães, Miriam Costa Oliveira, Maria Beatriz da Fonte Kohek
Despite recent advances in molecular genetics, the pituitary adenoma initiation, development, progress, and the molecular basis of their unique features are still poorly understood. In this sense, it is proposed that stem cell could be involved in pituitary adenoma tumorigenesis. It is suggested that TP63 has important functions in stem cells, and it may have interplay of TP63 and Notch and its ligand Jagged in this process. This study aimed to evaluate the distinct expression of TP63 isoforms (TAp63 and ΔNp63), as well as its correlation with Notch3 receptor and its ligand Jagged1 in human pituitary adenomas at the messenger RNA (mRNA) level...
January 11, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28064395/cu-ii-adsorption-from-copper-mine-water-by-chitosan-films-and-the-matrix-effects
#3
Tuanny S Frantz, Nauro Silveira, Maurízio S Quadro, Robson Andreazza, Amauri A Barcelos, Tito R S Cadaval, Luiz A A Pinto
Adsorption of copper ions onto chitosan films was studied, and the matrix effect was evaluated using a synthetic solution and a real effluent from closed copper mine. Chitosan films were prepared by casting technique and characterized. The adsorption study was carried out by equilibrium isotherms, thermodynamics, and kinetics. The thermodynamic parameters indicated that the copper adsorption onto chitosan film was favorable, spontaneous, and exothermic, suggesting an increased randomness at the solid/solution interface...
January 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28049833/antibiotic-stress-selects-against-cooperation-in-the-pathogenic-bacterium-pseudomonas-aeruginosa
#4
Marie Vasse, Robert J Noble, Andrei R Akhmetzhanov, Clara Torres-Barceló, James Gurney, Simon Benateau, Claire Gougat-Barbera, Oliver Kaltz, Michael E Hochberg
Cheats are a pervasive threat to public goods production in natural and human communities, as they benefit from the commons without contributing to it. Although ecological antagonisms such as predation, parasitism, competition, and abiotic environmental stress play key roles in shaping population biology, it is unknown how such stresses generally affect the ability of cheats to undermine cooperation. We used theory and experiments to address this question in the pathogenic bacterium, Pseudomonas aeruginosa Although public goods producers were selected against in all populations, our competition experiments showed that antibiotics significantly increased the advantage of nonproducers...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045920/alterations-in-evoked-otoacoustic-emissions-by-the-use-of-meglumine-antimoniate-in-american-tegumentary-leishmaniasis-patients
#5
Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
INTRODUCTION: Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28027981/occurrence-of-halogenated-flame-retardants-in-commercial-seafood-species-available-in-european-markets
#6
Òscar Aznar-Alemany, Laura Trabalón, Silke Jacobs, Vera Liane Barbosa, Margarita Fernández Tejedor, Kit Granby, Christiaan Kwadijk, Sara C Cunha, Federico Ferrari, Griet Vandermeersch, Isabelle Sioen, Wim Verbeke, Lolita Vilavert, José L Domingo, Ethel Eljarrat, Damià Barceló
PBDEs (congeners 28, 47, 99, 100, 153, 154, 183, 209), HBCD (α, β, γ), emerging brominated flame retardants (PBEB, HBB and DBDPE), dechloranes (Dec 602, 603, 604, syn- and anti-DP), TBBPA, 2,4,6-TBP and MeO-PBDEs (8 congeners) were analysed in commercial seafood samples from European countries. Levels were similar to literature and above the environmental quality standards (EQS) limit of the Directive 2013/39/EU for PBDEs. Contaminants were found in 90.5% of the seafood samples at n. d.-356 ng/g lw (n...
December 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28007354/gut-epithelial-barrier-markers-in-patients-with-obstructive-sleep-apnea
#7
Antonia Barceló, Cristina Esquinas, Juan Robles, Javier Piérola, Mónica De la Peña, Irene Aguilar, Daniel Morell-Garcia, Alberto Alonso, Nuria Toledo, Manuel Sánchez-de la Torre, Ferran Barbé
BACKGROUND: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. RESULTS: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28007035/sacral-agenesis-a-pilot-whole-exome-sequencing-and-copy-number-study
#8
Robert M Porsch, Elisa Merello, Patrizia De Marco, Guo Cheng, Laura Rodriguez, Manting So, Pak C Sham, Paul K Tam, Valeria Capra, Stacey S Cherny, Maria-Mercè Garcia-Barcelo, Desmond D Campbell
BACKGROUND: Caudal regression syndrome (CRS) or sacral agenesis is a rare congenital disorder characterized by a constellation of congenital caudal anomalies affecting the caudal spine and spinal cord, the hindgut, the urogenital system, and the lower limbs. CRS is a complex condition, attributed to an abnormal development of the caudal mesoderm, likely caused by the effect of interacting genetic and environmental factors. A well-known risk factor is maternal type 1 diabetes. METHOD: Whole exome sequencing and copy number variation (CNV) analyses were conducted on 4 Caucasian trios to identify de novo and inherited rare mutations...
December 22, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/28003453/size-evolution-in-microorganisms-masks-trade-offs-predicted-by-the-growth-rate-hypothesis
#9
Isabelle Gounand, Tanguy Daufresne, Dominique Gravel, Corinne Bouvier, Thierry Bouvier, Marine Combe, Claire Gougat-Barbera, Franck Poly, Clara Torres-Barceló, Nicolas Mouquet
Adaptation to local resource availability depends on responses in growth rate and nutrient acquisition. The growth rate hypothesis (GRH) suggests that growing fast should impair competitive abilities for phosphorus and nitrogen due to high demand for biosynthesis. However, in microorganisms, size influences both growth and uptake rates, which may mask trade-offs and instead generate a positive relationship between these traits (size hypothesis, SH). Here, we evolved a gradient of maximum growth rate (μmax) from a single bacterium ancestor to test the relationship among μmax, competitive ability for nutrients and cell size, while controlling for evolutionary history...
December 28, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28003150/concomitant-helminth-infection-downmodulates-the-vaccinia-virus-specific-immune-response-and-potentiates-virus-associated-pathology
#10
Pedro Henrique Gazzinelli-Guimarães, Lorena Falabella Daher de Freitas, Ana Clara Gazzinelli-Guimarães, Fabiana Coelho, Fernando Sérgio Barbosa, Denise Nogueira, Chiara Amorim, Lucas de Carvalho Dhom-Lemos, Luciana Maria Oliveira, Alexandre Barcelos da Silveira, Flávio Guimarães da Fonseca, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara
The aim of this work was to elucidate the immunopathological mechanisms of how helminths may influence the course of a viral infection, using a murine model. Severe virulence, a relevant increase in the virus titres in the lung and a higher mortality rate were observed in Ascaris and Vaccinia virus (VACV) co-infected mice, compared with VACV mono-infected mice. Immunopathological analysis suggested that the ablation of CD8(+) T cells, the marked reduction of circulating CD4(+) T cells producing IFN-γ, and the robust pulmonary inflammation were associated with the increase of morbidity/mortality in co-infection and subsequently with the negative impact of concomitant pulmonary ascariasis and respiratory VACV infection for the host...
December 18, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27993403/biopsy-of-the-sentinel-node-in-lung-cancer
#11
Naia Uribe-Etxebarria Lugariza-Aresti, Ramón Barceló Galíndez, Joaquín Pac Ferrer, Jaime Méndez Martín, Jose Genollá Subirats, Juan Casanova Viudez
INTRODUCTION AND OBJECTIVE: Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer. MATERIAL AND METHODS: Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99...
December 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27989941/a-multicentric-study-to-evaluate-the-use-of-relative-retention-times-in-targeted-proteomics
#12
Vital Vialas, Núria Colomé-Calls, Joaquín Abian, Kerman Aloria, Gloria Alvarez-Llamas, Oreto Antúnez, Jesus M Arizmendi, Mikel Azkargorta, Silvia Barceló-Batllori, María G Barderas, Francisco Blanco, J Ignacio Casal, Vanessa Casas, Carolina de la Torre, Eduardo Chicano-Gálvez, Felix Elortza, Guadalupe Espadas, Josep M Estanyol, Joaquín Fernandez-Irigoyen, Patricia Fernandez-Puente, María José Fidalgo, Manuel Fuentes, Marina Gay, Concha Gil, Alexandre Hainard, Maria Luisa Hernaez, Nieves Ibarrola, Arthur T Kopylov, Antonio Lario, Juan Antonio Lopez, María López-Lucendo, Miguel Marcilla, Anabel Marina-Ramírez, Gyorgy Marko-Varga, Luna Martín, Maria I Mora, Esperanza Morato-López, Javier Muñoz, Maria Antonia Odena, Eliandre de Oliveira, Irene Orera, Ignacio Ortea, Carla Pasquarello, Kevin B Ray, Melinda Rezeli, Isabel Ruppen, Eduard Sabidó, Manuel M Sanchez Del Pino, Jaime Sancho, Enrique Santamaría, Jesus Vazquez, Marta Vilaseca, Fernando Vivanco, James J Walters, Victor G Zgoda, Fernando J Corrales, Francesc Canals, Alberto Paradela
: Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT), has lately emerged as a powerful tool. The robustness, reproducibility and utility of this strategy were examined for the first time in a multicentric setting, involving 28 laboratories that included 24 of the Spanish network of proteomics laboratories (ProteoRed-ISCIII)...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27988825/milk-and-dairy-products-intake-is-associated-with-low-levels-of-lead-pb-in-workers-highly-exposed-to-the-metal
#13
Willian Robert Gomes, Paula Pícoli Devóz, Marília Ladeira Araújo, Bruno Lemos Batista, Fernando Barbosa, Gustavo Rafael Mazzaron Barcelos
Lead (Pb) is a toxic metal, frequently associated with occupational exposure, due to its widespread use in industry and several studies have shown high Pb levels in workers occupationally exposed to the metal. The aim of this study was to evaluate the influence of milk and dairy products (MDP) on Pb levels in blood (B-Pb), plasma (P-Pb), and urine (U-Pb), in workers from automotive battery industries in Brazil. The study included 237 male workers; information concerning diet and lifestyle were gathered through a questionnaire, and B-Pb, P-Pb, and U-Pb were determined by ICP-MS...
December 17, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27987692/bioactive-materials-improve-some-physical-properties-of-a-mta-like-cement
#14
A Flores-Ledesma, F Barceló Santana, L Bucio, J A Arenas-Alatorre, M Faraji, A M Wintergerst
One of the main disadvantages of MTA is its long setting time which could result in higher solubility and microleakage, producing a failed treatment. Studies have shown that the addition of bioactive glass may decrease the setting time. The aim of this study is to evaluate the compressive strength, setting time, solubility and radiopacity of a MTAlike experimental cement to which different percentage of wollastonite and bioactive glass are added. White MTA Angelus® was used as control; an experimental MTA-like cement (ExpC) was prepared using white Portland cement with 20wt% of Bi2O3; three wollastonite cement composites were prepared adding 10, 20 and 30wt% of wollastonite to ExpC, and three more adding the same proportions of bioactive glass...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987651/multifunctional-theranostic-pluronic-mixed-micelles-improve-targeted-photoactivity-of-verteporfin-in-cancer-cells
#15
Diogo Silva Pellosi, Italo Rodrigo Calori, Leonardo Barcelos de Paula, Noboru Hioka, Fabiana Quaglia, Antonio Claudio Tedesco
Nanotechnology development provides new strategies to treat cancer by integration of different treatment modalities in a single multifunctional nanoparticle. In this scenario, we applied the multifunctional Pluronic P123/F127 mixed micelles for Verteporfin-mediated photodynamic therapy in PC3 and MCF-7 cancer cells. Micelles functionalization aimed the targeted delivery by the insertion of biotin moiety on micelle surface and fluorescence image-based through rhodamine-B dye conjugation in the polymer chains...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27955658/genetic-study-of-congenital-bile-duct-dilatation-identifies-de-novo-and-inherited-variants-in-functionally-related-genes
#16
John K L Wong, Desmond Campbell, Ngoc Diem Ngo, Fanny Yeung, Guo Cheng, Clara S M Tang, Patrick H Y Chung, Ngoc Son Tran, Man-Ting So, Stacey S Cherny, Pak C Sham, Paul K Tam, Maria-Mercè Garcia-Barcelo
BACKGROUND: Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians. To our knowledge, no genetic study has ever been conducted. METHODS: We aim to identify genetic risk factors by a "trio-based" exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced. Seven-hundred controls from the local population were used to detect gene-sets significantly enriched with rare variants in CDD patients...
December 12, 2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27943564/factors-affecting-the-incidence-of-early-endoscopic-recurrence-after-ileocolonic-resection-for-crohn-s-disease-a-multicentre-observational-study
#17
I F de Barcelos, P G Kotze, A Spinelli, Y Suzuki, F V Teixeira, I C de Albuquerque, R Saad-Hossne, L M da Silva Kotze, T Yamamoto
AIM: Early endoscopic recurrence is frequently observed in patients following resection for Crohn's disease (CD). However, factors affecting the incidence of an early postoperative endoscopic recurrence (EPER) have not been fully determined. The aim of this study was to evaluate risk factors for EPER after ileocolonic resection for CD. METHOD: This was a retrospective, international multicentre study, in which 127 patients with a first ileocolonoscopy conducted between 6 and 12 months after ileocolonic resection for CD were included...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27934501/orthogonally-protected-1-2-diols-from-electron-rich-alkenes-using-metal-free-olefin-syn-dihydroxylation
#18
Ignacio Colomer, Rosimeire Coura Barcelos, Kirsten E Christensen, Timothy J Donohoe
A new method for the stereoselective metal-free syn-dihydroxylation of electron-rich olefins is reported, involving reaction with TEMPO/IBX in trifluoroethanol (TFE) or hexafluoroisopropanol (HFIP) and the addition of a suitable nucleophile. Orthogonally protected syn 1,2-diols were obtained with high levels of diastereocontrol, and these products were selectively deprotected and selectively functionalized into synthetically useful compounds.
November 18, 2016: Organic Letters
https://www.readbyqxmd.com/read/27929530/effects-of-delayed-cord-clamping-on-residual-placental-blood-volume-hemoglobin-and-bilirubin-levels-in-term-infants-a-randomized-controlled-trial
#19
J S Mercer, D A Erickson-Owens, J Collins, M O Barcelos, A B Parker, J F Padbury
OBJECTIVE: The objective of the study was to measure the effects of a 5-min delay (DCC) versus immediate cord clamping (ICC) on residual placental blood volume (RPBV) at birth, and hemoglobin and serum bilirubin at 24 to 48 h of age. STUDY DESIGN: In this prospective randomized controlled trial, 73 women with term (37 to 41 weeks) singleton fetuses were randomized to DCC (⩾5 min; n=37) or ICC (<20 s; n=36). RESULTS: Maternal and infant demographics were not different between the groups...
December 8, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27925327/crystal-structure-of-a-metalled-double-helix-generated-by-infinite-and-consecutive-c-agi-c-c-n1-hexylcytosine-base-pairs-through-argentophilic-and-hydrogen-bond-interactions
#20
Angel Terron, Blas Moreno-Vachiano, Antonio Bauza, Angel Garcia-Raso, Juan J Fiol, Miquel Barcelo-Oliver, Elies Molins, Antonio Frontera
The synthesis of a metalled double-helix containing exclusively silver-mediated C*-C* base pairs is reported herein (C* = N1hexylcytosine). Remarkably, it is the first crystal structure containing infinite and consecutive C*-AgI-C* base pairs that form a double helix. The AgI ion occupies the center between two C* residues with N(3)-Ag bond distances of 2.1 Å and short AgI-AgI distances (3.1 Å) suggesting an interesting argentophilic attraction as a stabilization source of the helical disposition. The solid state structure is further stabilized by metal-mediated base-pairs, hydrogen bonding and π-stacking interactions...
December 7, 2016: Chemistry: a European Journal
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