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https://www.readbyqxmd.com/read/29667271/syndrome-and-outcome-of-antibody-negative-limbic-encephalitis
#1
Francesc Graus, Domingo Escudero, Laura Oleaga, Jordi Bruna, Alberto Villarejo-Galende, Jordi Ballabriga, María Inés Barceló, Francisco Gilo, Stoyan Popkirov, Pavel Stourac, Josep Dalmau
OBJECTIVE: To report the clinical characteristics of 12 patients with limbic encephalitis (LE) who were antibody-negative after a comprehensive immunological study. METHODS: Review of clinical records of 163 patients with LE. Immunohistochemistry on rat brain, cultured neurons, and cell-based assays were used to identify neuronal autoantibodies. Patients were included if 1) there was adequate clinical, CSF, and MRI information to classify the syndrome as LE, 2) MRI images were accesible for central review, and 3) serum and CSF were available and confirmed negative for neuronal antibodies...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29663516/a-2-year-prospective-study-of-single-implant-mandibular-overdentures-patient-reported-outcomes-and-prosthodontic-events
#2
Túlio Eduardo Nogueira, Fernanda Maria Oliveira Aguiar, Bento Alves de Barcelos, Cláudio Rodrigues Leles
OBJECTIVE: This prospective clinical trial aimed to assess clinical and patient-reported outcomes of the single-implant mandibular overdenture treatment (SIMO) after a 2-year follow-up period. MATERIALS AND METHODS: An external hexagon implant was inserted in the mandibular midline of 45 complete denture wearers. Participants had a mean age of 63.4 (SD = 8.3), and 75.6% were female. Based on the primary stability of the implant, immediate loading was performed in 38 patients (84...
April 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29660870/differential-behavioural-responses-to-venlafaxine-exposure-route-warming-and-acidification-in-juvenile-fish-argyrosomus-regius
#3
Ana Luísa Maulvault, Lúcia H M L M Santos, José Ricardo Paula, Carolina Camacho, Vasco Pissarra, Fabiola Fogaça, Vera Barbosa, Ricardo Alves, Pedro Pousão Ferreira, Damià Barceló, Sara Rodriguez-Mozaz, António Marques, Mário Diniz, Rui Rosa
Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and survival. Yet, the underlying interactions between these environmental stressors (pharmaceuticals exposure and climate change) are still far from being fully understood...
April 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29643951/effectiveness-of-surface-cleaning-and-disinfection-in-a-brazilian-healthcare-facility
#4
Aires G Santos-Junior, Adriano M Ferreira, Oleci P Frota, Marcelo A Rigotti, Larissa da S Barcelos, Alvaro Francisco Lopes de Sousa, Denise de Andrade, Odanir G Guerra, Mara C R Furlan
Background: Failures in the processes of cleaning and disinfecting health service surfaces may result in the spread and transfer of pathogens that are often associated with healthcare-related infections and outbreaks. Aims: To assess the effectiveness of environmental surface cleaning and disinfection in a hospital clinic. Method: The study was conducted in a nursing ward with 45 beds. A total of 80 samples from five high-touch surfaces were evaluated before and after cleaning and disinfection, using the following methods: visual inspection, adenosine triphosphate bioluminescence assay, aerobic colony count, Staphylococcus aureus colony count, and evaluation of resistance to methicillin...
2018: Open Nursing Journal
https://www.readbyqxmd.com/read/29627563/ecological-and-ecotoxicological-responses-in-the-assessment-of-the-ecological-status-of-freshwater-systems-a-case-study-of-the-temporary-stream-brejo-of-cagarr%C3%A3-o-south-of-portugal
#5
P Palma, C Matos, P Alvarenga, M Köck-Schulmeyer, I Simões, D Barceló, M J López de Alda
The objective of the study was to assess the integrated use of macroinvertebrate indexes and ecotoxicological parameters in the evaluation of the ecological status of a temporary stream with a strong agricultural influence. Water quality was analysed at two sampling sites along the stream, considering: chemical supporting parameters; hazardous substances (pesticides); benthic macroinvertebrate communities, through quality (Iberian Biological Monitoring Working Party and Iberian Average Score Per Taxon) and multi-metric indices (Southern Portuguese Index of Invertebrates and Ecological Quality Ratio); and ecotoxicological responses using lethal and sub-lethal bioassays...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29623827/comparative-assay-of-2d-and-3d-cell-culture-models-proliferation-gene-expression-and-anticancer-drug-response
#6
Aline G Souza, Isaura Beatriz B Silva, Esther Campos-Fernandez, Leticia S Barcelos, Jessica Brito Souza, Karina Marangoni, Luiz R Goulart, Vivian Alonso-Goulart
In vitro tests allow establishing experimental variables. However, in vitro results cannot be extrapolated to in vivo tests. Considering that three-dimensional (3D) culture has been one of the best ways to portray the in vivo system of most cell types, it is possible to carry out assays with a great clinical relevance for the analysis of the screening, action and resistance of antitumor drugs. Thus, the objective of the present study was to compare between 2D and 3D cell culture forms to conclude which is the most suitable model for preclinical in vitro drug testing...
April 4, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29623391/association-between-memory-b-cells-and-clinical-and-immunological-features-of-primary-sj%C3%A3-gren-s-syndrome-and-sicca-patients
#7
Filipe Barcelos, Catarina Martins, Ana Papoila, Carlos Geraldes, Joana Cardigos, Glória Nunes, Teresa Lopes, Nuno Alves, José Vaz-Patto, Jaime Branco, Luís-Miguel Borrego
B-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29...
April 6, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29605406/micro-rna-profile-and-proteins-in-peritoneal-fluid-from-women-with-endometriosis-their-relationship-with-sterility
#8
Josep Marí-Alexandre, Moisés Barceló-Molina, Elisa Belmonte-López, Javier García-Oms, Amparo Estellés, Aitana Braza-Boïls, Juan Gilabert-Estellés
OBJECTIVE: To define the microRNA (miRNA) profile and its relationship with cytokines content in peritoneal fluid (PF) from endometriosis patients. DESIGN: Case-control study. SETTING: University hospital, research institute. PATIENT(S): One hundred twenty-six women with endometriosis (EPF) and 45 control women (CPF). MAIN OUTCOMES MEASURE(S): MiRNA arrays were prepared from six EPF and six CPF...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29602163/portuguese-recommendations-for-the-prevention-diagnosis-and-management-of-primary-osteoporosis-2018-update
#9
A M Rodrigues, H Canhão, A Marques, C Ambrósio, J Borges, P Coelho, L Costa, S Fernandes, I Gonçalves, M Gonçalves, M Guerra, M L Marques, S Pimenta, P Pinto, G Sequeira, E Simões, L Teixeira, C Vaz, E Vieira-Sousa, R Vieira, F Alvarenga, F Araújo, A Barcelos, F Barcelos, R Barros, M Bernardes, J Canas da Silva, A Cordeiro, M Costa, L Cunha-Miranda, M Cruz, A C Duarte, C Duarte, A Faustino, G Figueiredo, J E Fonseca, C Furtado, J Gomes, C Lopes, A F Mourão, M Oliveira, F M Pimentel-Santos, A Ribeiro, T Sampaio da Nóvoa, M Santiago, C Silva, A Silva-Dinis, S Sousa, J Tavares-Costa, G Terroso, A Vilar, J C Branco, V Tavares, J C Romeu, Jap da Silva
BACKGROUND: Advances in osteoporosis (OP)case definition, treatment options, optimal therapy duration and pharmacoeconomic evidence in the national context motivated the Portuguese Society of Rheumatology (SPR) to update the Portuguese recommendations for the diagnosis and management of osteoporosis published in 2007. METHODS: SPR bone diseases' working group organized meetings involving 55 participants (rheumatologists, rheumatology fellows and one OP specialist nurse) to debate and develop the document...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29590357/hip-fractures-in-people-over-95-years-old-are-patients-without-age-associated-illnesses-different
#10
Montserrat Barceló, Olga Torres, Domingo Ruiz, Jordi Casademont
Background: Patients over 95 years of age can be categorized according to three morbidity profiles: escapers, delayers and survivors. The aim of this study was to describe the baseline characteristics, in-hospital outcomes and cumulative mortality of extremely elderly patients admitted with hip fractures and to examine whether there were differences between patients without age-related illnesses (escapers) and others in the same age group (survivors when age-associated illnesses were diagnosed before the age of 80, delayers when these illnesses appeared after the age of 80)...
March 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29584648/the-nothoaspis-amazoniensis-complete-mitogenome-a-comparative-and-phylogenetic-analysis
#11
Paulo H C Lima, Pedro M P Vidigal, Rafael M Barcelos, Raphael C Klein, Carlos E Montandon, Mary H Fabres-Klein, Jorge A Dergam, José M Venzal, Cláudio Mafra
The molecular biology era, together with morphology, molecular phylogenetics, bioinformatics, and high-throughput sequencing technologies, improved the taxonomic identification of Argasidae family members, especially when considering specimens at different development stages, which remains a great difficulty for acarologists. These tools could provide important data and insights on the history and evolutionary relationships of argasids. To better understand these relationships, we sequenced and assembled the first complete mitochondrial genome of Nothoaspis amazoniensis ...
March 27, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29579124/correction-peripheral-organs-of-dengue-fatal-cases-present-strong-pro-inflammatory-response-with-participation-of-ifn-gamma-tnf-alpha-and-rantes-producing-cells
#12
Tiago F Póvoa, Edson R A Oliveira, Carlos A Basílio-de-Oliveira, Gerard J Nuovo, Vera L A Chagas, Natália G Salomão, Ada Maria de Barcelos Alves, Ester M Mota, Marciano V Paes
[This corrects the article DOI: 10.1371/journal.pone.0168973.].
2018: PloS One
https://www.readbyqxmd.com/read/29577602/lack-of-interferon-gamma-attenuates-foreign-body-reaction-to-subcutaneous-implants-in-mice
#13
Puebla Cassini-Vieira, Melissa de Carvalho Santuchi, Rafaela Fernandes da Silva, Remo Castro Russo, Fernanda Assis Araújo, Robson Augusto Souza Dos Santos, Silvia Passos Andrade, Mauro Martins Teixeira, Luciola Silva Barcelos
Subcutaneous implantation of synthetic materials and biomedical devices often induces abnormal tissue healing - the foreign body reaction - which impairs their function. In particular, Interferon-γ (IFN-γ) is a critical endogenous mediator of inflammation and plays a key role in a wide variety of biological responses including tissue healing. However, the contribution of endogenous IFN-γ on different features of the foreign body response induced by synthetic implants regarding neovascularization, inflammation, and fibrogenesis is not well known...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29574011/residue-of-insecticides-in-foodstuff-and-dietary-exposure-assessment-of-brazilian-citizens
#14
Alexsandro Dallegrave, Tânia M Pizzolato, Fabiano Barreto, Vinicius C Bica, Ethel Eljarrat, Damià Barceló
The goal of this work is to study the presence of 17 different pyrethroids and chlorpyrifos in animal origin food samples, including chicken, beef, fish, eggs and milk. The samples were analyzed by GC/NCI-MS/MS in order to determine their insecticide concentration levels, the relation between the amount of insecticides and the lipid content, as well as their isomeric composition. Bifenthrin, cypermethrin, cyhalothrin, permethrin, deltamethrin and chlorpyrifos have been detected in real samples. The highest levels find were verified for chlorpyrifos (45...
March 21, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29548639/-infection-outbreak-due-to-an-enterovirus-causing-severe-neurological-complications-in-a-tertiary-hospital
#15
Andrea María Leal Barceló, Paula Carrascosa García, Elena María Rincón López, María Concepción Miranda Herrero, María Luisa Navarro
No abstract text is available yet for this article.
March 13, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29544809/a-perspective-of-mitochondrial-dysfunction-in-rats-treated-with-silver-and-titanium-nanoparticles-agnps-and-tinps
#16
Lilian Cristina Pereira, Murilo Pazin, Mariana Furio Franco-Bernardes, Airton da Cunha Martins, Gustavo Rafael Mazzaron Barcelos, Márcio Cesar Pereira, João Paulo Mesquita, Jairo Lisboa Rodrigues, Fernando Barbosa, Daniel Junqueira Dorta
Nanotechnology is a growing branch of science that deals with the development of structural features bearing at least one dimension in the nano range. More specifically, nanomaterials are defined as objects with dimensions that range from 1 to 100 nm, which give rise to interesting properties. In particular, silver and titanium nanoparticles (AgNPs and TiNPs, respectively) are known for their biological and biomedical properties and are often used in consumer products such as cosmetics, food additives, kitchen utensils, and toys...
May 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29538510/opportunistic-and-non-opportunistic-intestinal-parasites-in-hiv-aids-patients-in-relation-to-their-clinical-and-epidemiological-status-in-a-specialized-medical-service-in-goi%C3%A3-s-brazil
#17
Natane Barbosa Barcelos, Lorena de Freitas E Silva, Regyane Ferreira Guimarães Dias, Hélio Ranes de Menezes Filho, Rosângela Maria Rodrigues
Patients infected with the Human Immunodeficiency Virus (HIV) often have opportunistic infections, among which strongyloidiasis and coccidiosis are the most common parasitic infections that aggravate their health status. This study examined the prevalence of intestinal parasites, particularly of Strongyloides stercoralis and intestinal coccidia in patients with the Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) who were treated at the Specialized Assistance Service (SAE) of Jataí, State of Goiás, Brazil, and analyzed its correlation with clinical, laboratory, and socio-epidemiological parameters...
March 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29535704/linking-the-effect-of-antibiotics-on-partial-nitritation-biofilters-performance-microbial-communities-and-microbial-activities
#18
Alejandro Gonzalez-Martinez, Alejandro Margareto, Alejandro Rodriguez-Sanchez, Chiara Pesciaroli, Silvia Diaz-Cruz, Damia Barcelo, Riku Vahala
The emergence and spread of antibiotics resistance in wastewater treatment systems have been pointed as a major environmental health problem. Nevertheless, research about adaptation and antibiotics resistance gain in wastewater treatment systems subjected to antibiotics has not been successfully developed considering bioreactor performance, microbial community dynamics and microbial activity dynamics at the same time. To observe this in autotrophic nitrogen removal systems, a partial-nitritation biofilter was subjected to a continuous loading of antibiotics mix of azithromycin, norfloxacin, trimethoprim, and sulfamethoxazole...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29529566/determining-the-presence-of-chemicals-with-suspected-endocrine-activity-in-drinking-water-from-the-madrid-region-spain-and-assessment-of-their-estrogenic-androgenic-and-thyroidal-activities
#19
Y Valcárcel, A Valdehíta, E Becerra, M López de Alda, A Gil, M Gorga, M Petrovic, D Barceló, J M Navas
Endocrine disruptors (EDs) are natural or man-made chemicals that can affect the health of organisms by interfering with their normal hormonal functions. Many of these substances can cause their effects at very low doses and, considering the key role played by the endocrine system on development, organisms in early phases of growth (foetal, childhood, puberty) are especially sensitive to the action of EDs. In addition, when combined, they can show additive, antagonistic and synergistic activities. Taking all this into account it is essential to determine the presence of this kind of compounds in drinking water...
February 22, 2018: Chemosphere
https://www.readbyqxmd.com/read/29515383/functional-dissociation-of-latency-variable-stimulus-and-response-locked-target-p3-sub-components-in-task-switching
#20
Christopher R Brydges, Francisco Barceló
Cognitive control warrants efficient task performance in dynamic and changing environments through adjustments in executive attention, stimulus and response selection. The well-known P300 component of the human event-related potential (ERP) has long been proposed to index "context-updating"-critical for cognitive control-in simple target detection tasks. However, task switching ERP studies have revealed both target P3 (300-350 ms) and later sustained P3-like potentials (400-1,200 ms) to first targets ensuing transition cues, although it remains unclear whether these target P3-like potentials also reflect context updating operations...
2018: Frontiers in Human Neuroscience
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