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https://www.readbyqxmd.com/read/29024886/a-case-study-to-identify-priority-cytostatic-contaminants-in-hospital-effluents
#1
A Olalla, N Negreira, M López de Alda, D Barceló, Y Valcárcel
This study analyses the presence of 17 cytostatic agents from seven different groups, based on their different mechanisms of action, in the effluent from a medium-sized hospital located in eastern Spain. Analysis of the compounds found in the effluents studied involved solidphase extraction (SPE) coupled on-line to a high performance liquid chromatograph tandem mass spectrometer (HPLC-MS/MS). The environmental risk of the compounds studied was then assessed by calculating the hazard quotient (HQ), combining the measured environmental concentrations (MECs) with dose-response data based on the predicted no effect concentrations (PNECs)...
September 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29019590/schinus-terebinthifolius-raddi-aroeira-leaves-oil-attenuates-inflammatory-responses-in-cutaneous-wound-healing-in-mice-1
#2
Lígia Reis Moura Estevão, Ricardo Santos Simões, Puebla Cassini-Vieira, Maria Cecilia Campos Canesso, Lucíola da Silva Barcelos, Milene Alvarenga Rachid, Cláudio Augusto Gomes da Câmara, Joaquim Evêncio-Neto
PURPOSE: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. METHODS: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO- treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28992490/does-the-presence-of-caffeine-in-the-marine-environment-represent-an-environmental-risk-a-regional-and-global-study
#3
Raquel Dafouz, Neus Cáceres, José Luis Rodríguez-Gil, Nicola Mastroianni, Miren López de Alda, Damià Barceló, Ángel Gil de Miguel, Yolanda Valcárcel
Caffeine is an emerging contaminant considered to be an indicator of human contamination that has been widely detected in various aquatic systems, especially in continental waters. Nevertheless, the extent of its possible environmental impact is yet to be determined. This study determined the presence of caffeine, and evaluated the environmental hazard posed by this substance, in the "Rías Gallegas", a series of costal inlets in north-west Spain which are of great ecological value and in which fishing and bivalve farming, are a significant source of income...
October 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28990958/chronic-obstructive-pulmonary-disease-in-the-long-term-care-setting-current-practices-challenges-and-unmet-needs
#4
Manuel Suarez-Barcelo, Joseph L Micca, Sharon Clackum, Gary T Ferguson
: Chronic obstructive pulmonary disease (COPD) is a prevalent and disabling disorder in the United States, especially affecting older individuals, women, and those with a history of smoking. Studies show that COPD may be underrepresented, underdiagnosed, and undertreated in elderly patients residing in long-term care (LTC) facilities. The quality of care for LTC residents with COPD is heterogeneous in regard to both the facility and the patient. For LTC facilities, care should be driven by staff education, interstaff communication, and interfacility communication...
November 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28990135/text-messaging-sms-helping-cancer-care-in-patients-undergoing-chemotherapy-treatment-a-pilot-study
#5
Timóteo Matthies Rico, Karina Dos Santos Machado, Vanessa Pellegrini Fernandes, Samanta Winck Madruga, Patrícia Tuerlinckx Noguez, Camila Rose Guadalupe Barcelos, Mateus Madail Santin, Cristiane Rios Petrarca, Samuel Carvalho Dumith
Cancer treatment is an extremely stressful life experience that is accompanied by a range of psychological, social, physical, and practical difficulties. Cancer patients need to receive information that helps them to better understand the disease, assists them in decision-making, and helps them deal with treatment. Patients are interested in receiving such information. The degree of satisfaction with the information received has been associated with positive health outcomes, specifically regarding quality of life, severity of side effects, and psychological well-being...
October 9, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28988012/healing-activity-of-proteolytic-fraction-p1g10-from-vasconcellea-cundinamarcensis-in-a-cutaneous-wound-excision-model
#6
K M Freitas, L S Barcelos, M V Caliari, C E Salas, M T P Lopes
The proteolytic enzymes from Vasconcellea cundinamarcensis have demonstrated efficacy to accelerate healing of skin lesions. We report here the efficacy of the proteolytic fraction - P1G10 during repair of excisional wounds in rodent model and analyze possible mediators involved. Using 0.05% P1G10 we observed on day 3rd increased wound contraction accompanied by an increase in activated neutrophils and VEGF relative to the control. On day 7th neutrophils returned to normal levels, and at 0.01% P1G10, an increase in NAG activity used to monitor monocyte/macrophage, was observed...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28987731/how-do-measured-pbde-and-hcbd-levels-in-river-fish-compare-to-the-european-environmental-quality-standards
#7
Ethel Eljarrat, Damià Barceló
This study evaluates the current situation regarding PBDE and HBCD levels in different river fish species. We collected published data in the last five years in different countries around the world. These levels of pollution were compared with Environmental Quality Standards (EQS) for biota established by the European Directive in the field of water policy. Although HBCD situation is not critical, with only some values exceeding the limit about 5 times, the PBDE levels clearly exceeded the established EQS, with 25% of fish samples exceeding up to ten thousand times...
October 5, 2017: Environmental Research
https://www.readbyqxmd.com/read/28987235/effects-of-l-arginine-supplementation-associated-with-continuous-or-interval-aerobic-training-on-chronic-heart-failure-rats
#8
Giovanna Tedesco Barcelos, Douglas Dalcin Rossato, Júlia Luiza Perini, Lucas Pereira Pinheiro, Carol Carvalho, Rodrigo Boemo Jaenisch, Cláudia Ramos Rhoden, Pedro Dal Lago, Ramiro Barcos Nunes
OBJECTIVE: Chronic heart failure (CHF) is related with exercise intolerance and impaired nitric oxide (NO) production, which can lead to several functional capacity alterations. Considering the possible superiority of aerobic interval training compared to continuous training and the capacity of l-arginine to restore the NO pathway, the aim of the present study was to investigate whether these treatments are beneficial to exercise capacity, muscle mass preservation and hemodynamic, inflammatory and oxidative stress parameters in CHF rats...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28985315/cross-reactivity-of-pantoprazole-with-three-commercial-cannabinoids-immunoassays-in-urine
#9
Isabel Gomila, Bernardino Barceló, Antonio Rosell, Sonia Avella, Laura Sahuquillo, Macarena Dastis
Pantoprazole is a frequently prescribed proton pump inhibitor (PPI) commonly utilized in the management of gastrointestinal symptoms. Few substances have proved to cause a false-positive cannabinoid urine screen. However, a case of false-positive urine cannabinoid screen in a patient who received a pantoprazole dose has been recently published. The purpose of this study was to determine the potential cross-reactivity of pantoprazole in the cannabinoid immunoassays: Alere Triage® TOX Drug Screen, KIMS® Cannabinoids II and DRI® Cannabinoids Assay...
July 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28976843/stress-distribution-tooth-remaining-strain-and-fracture-resistance-of-endodontically-treated-molars-restored-without-or-with-one-or-two-fiberglass-posts-and-direct-composite-resin
#10
L M Barcelos, A A Bicalho, C Veríssimo, M P Rodrigues, C J Soares
OBJECTIVES: To evaluate the effects of direct composite resin without a post or with one or two fiberglass posts on the restoration of severely compromised endodontically treated molars. METHODS AND MATERIALS: Forty-five molars with 2 mm of "remaining tooth structure" were divided into three groups: Wfgp, restored with Filtek Z350XT without a fiberglass post; 1fgp, restored with Z350XT with one fiberglass post in the distal root canal; and 2fgp, restored with Z350XT with two fiberglass posts, one in the distal root canal and the other in the mesial-buccal root canal...
October 4, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28975809/cross-reactivity-of-selected-benzofurans-with-commercial-amphetamine-and-ecstasy-immunoassays-in-urine
#11
Isabel Gomila, Concepción Moranta, Loreto Quesada, Yolanda Pastor, Macarena Dastis, Albert Torrents, Miguel Ángel Elorza, Francesco Paolo Busardò, Bernardino Barceló
AIM: The aim of this study was to perform a cross-reactivity investigation of six benzofurans with immunoassays (IAs) screening tests for amphetamines and ecstasy in urine samples. METHODS: The following benzofuranes were investigated: 5-(2-Methylaminopropyl)Benzofuran (5-MAPB), 5-(2-methylaminopropyl)-2,3-dihydrobenzofuran (5-MAPDB), 5-(2-Aminopropyl)-Benzofuran (5-APB), 5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB), 5-(2-Ethylaminopropyl)Benzofuran (5-EAPB) and 5-(2-Aminoethyl)-2,3-dihydrobenzofuran (5-AEDB)...
October 4, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28975143/data-of-pcl-b-p-mma-dmaema-2-characterization-and-related-assays
#12
Camila Franco, Michelli Barcelos Antonow, Aline Beckenkamp, Andréia Buffon, Taise Ceolin, Marli Luiza Tebaldi, Gustavo Pozza Silveira, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann
The data presented here are related to the research paper entitled "PCL-b-P(MMA-co-DMAEMA)2 new triblock copolymer for novel pH-sensitive nanocapsules intended for drug delivery to tumors" by Franco et al. [1]. Characterization data of PCL-diol, macroinitiator Br-PCL-Br, homopolymers (PMMA and PDMAEMA) and copolymers (batch 1 and batch 2) analyzed by FTIR, SEC and NMR, as well as, characterization of PCL-NS formulation by laser diffraction and DLS analysis, initial nanocapsule formulations and 1C-NC and 2C-NC formulations, including hydrodynamic diameter at different pH media, and DMSO cytotoxicity...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28974443/toxicological-aspects-of-the-interesterified-fat-from-processed-foods-influences-on-opioid-system-and-its-reward-effects-in-rats
#13
Laura H Milanesi, Karine Roversi, Caren T D Antoniazzi, Hecson J Segat, Maikel Kronbauer, Lívia F D'avila, Verônica T Dias, Marcel H M Sari, Raquel C S Barcelos, Luana H Maurer, Tatiana Emanuelli, Marilise E Burger, Fabíola Trevizol
Considering the high consumption of processed foods, interesterified fat (IF) has been used to replace trans fat, since it may harm nervous system functions. Opioids are intensely used to alleviate pain, and have a highly addictive potential. Therefore, their improper use is related to addiction, tolerance, and withdrawal syndrome. Wistar rats received soybean oil (SO) or IF during gestation, lactation and post-weaning until pups' adolescence. On post-natal day 39, animals received morphine (4 mg/kg i.p.) in the conditioned place preference (CPP) paradigm...
September 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28964775/influence-of-physical-activity-on-addiction-parameters-of-rats-exposed-to-amphetamine-which-were-previously-supplemented-with-hydrogenated-vegetable-fat
#14
H J Segat, R C S Barcelos, V G Metz, H Z Rosa, Kr Roversi, C T D Antoniazzi, L T Vey, M Kronbauer, J C Veit, J C Piccolo, T Emanuelli, M E Burger
Amphetamine (AMPH) and its derivatives are addictive drugs used to promote and enhance alertness, motivation, willingness, courage and wellbeing. However, their chronic use is related to memory loss, emotional instability, insomnia, psychosis and paranoia. In the last decades, modern society has included processed foods, rich in trans fatty acids (TFA), in their diet, what has been related to several health problems including increased AMPH preference and self-administration. In this scenario, physical activity appears to be useful to attenuate rewarding symptoms related to addictive drugs mainly by affecting brain neuroplasticity and neurotransmission...
September 28, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28962074/study-of-pharmaceuticals-in-surface-and-wastewater-from-cuernavaca-morelos-mexico-occurrence-and-environmental-risk-assessment
#15
José Abraham Rivera-Jaimes, Cristina Postigo, Rosa María Melgoza-Alemán, Jaume Aceña, Damia Barceló, Miren López de Alda
The present work describes the first known study to date on the occurrence of pharmaceuticals in surface water and wastewater of Cuernavaca, the capital of the state of Morelos (México). Selected pharmaceuticals (a total of 35) were extracted from the collected water samples with a generic solid phase extraction (SPE) protocol and determined in the sample extracts by means of high-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on predicted no-effect concentrations (PNECs) was also applied to estimate Hazard Quotients (HQs) for the pharmaceuticals detected in the investigated area...
September 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28943462/dna-polymeric-films-as-a-support-for-cell-growth-as-a-new-material-for-regenerative-medicine-compatibility-and-applicability
#16
Cristiano Ceron Jayme, Leonardo Barcelos de Paula, Nayara Rezende, Italo Rodrigo Calori, Leonardo Pereira Franchi, Antonio Claudio Tedesco
DNA polymeric films (DNA-PFs) are a promising drug delivery system (DDS) in modern medicine. In this study, we evaluated the growth behavior of oral squamous cell carcinoma (OSCC) cells on DNA-PFs. The morphological, biochemical, and cytometric features of OSCC cell adhesion on DNA-PFs were also assessed. An initial, temporary alteration in cell morphology was observed at early time points owing to the inhibition of cell attachment to the film, which then returned to a normal morphological state at later time points...
September 21, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28923414/a-proteomic-approach-to-the-mechanisms-underlying-activation-of-aluminium-resistance-in-roots-of-urochloa-decumbens
#17
Catalina Arroyave, Roser Tolrà, Livia Chaves, Marcelo Claro de Souza, Juan Barceló, Charlotte Poschenrieder
The mechanisms of extreme Al-resistance in Urochloa decumbens are not established. Full resistance expression requires a lag time of 72-96h and is preceded by a sensitive phase (24-48h) with Al-induced root growth inhibition. The aim here was to identify key processes of the activation phase of Al-resistance analysing both root exudates and comparative root proteome. Samples were taken after 0, 24 and 96h exposure to 0 or 200μM Al. Al-induced stimulation of citrate and oxalate efflux was limited to the sensitive phase...
September 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28917219/reuma-pt-contribution-to-the-knowledge-of-immune-mediated-systemic-rheumatic-diseases
#18
Maria José Santos, Helena Canhão, Ana Filipa Mourão, Filipa Oliveira Ramos, Cristina Ponte, Cátia Duarte, Anabela Barcelos, Fernando Martins, José António Melo Gomes
Patient registries are key instruments aimed at a better understanding of the natural history of diseases, at assessing the effectiveness of therapeutic interventions, as well as identifying rare events or outcomes that are not captured in clinical trials. However, the potential of registries goes far beyond these aspects. For example, registries promote the standardization of clinical practice, can also provide information on domains that are not routinely collected in clinical practice and can support decision-making...
July 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28899446/affective-and-emotional-dysregulation-as-pre-dementia-risk-markers-exploring-the-mild-behavioral-impairment-symptoms-of-depression-anxiety-irritability-and-euphoria
#19
Zahinoor Ismail, Jennifer Gatchel, Daniel R Bateman, Ricardo Barcelos-Ferreira, Marc Chantillon, Judith Jaeger, Nancy J Donovan, Moyra E Mortby
BACKGROUND: Affective and emotional symptoms such as depression, anxiety, euphoria, and irritability are common neuropsychiatric symptoms (NPS) in pre-dementia and cognitively normal older adults. They comprise a domain of Mild Behavioral Impairment (MBI), which describes their emergence in later life as an at-risk state for cognitive decline and dementia, and as a potential manifestation of prodromal dementia. This selective scoping review explores the epidemiology and neurobiological links between affective and emotional symptoms, and incident cognitive decline, focusing on recent literature in this expanding field of research...
September 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28898803/cytotoxic-effects-of-commonly-used-nanomaterials-and-microplastics-on-cerebral-and-epithelial-human-cells
#20
Gabriella F Schirinzi, Ignacio Pérez-Pomeda, Josep Sanchís, Cesare Rossini, Marinella Farré, Damià Barceló
Plastic wastes are among the major inputs of detritus into aquatic ecosystems. Also, during recent years the increasing use of new materials such as nanomaterials (NMs) in industrial and household applications has contributed to the complexity of waste mixtures in aquatic systems. The current effects and the synergism and antagonisms of mixtures of microplastics (MPLs), NMs and organic compounds on the environment and in human health have, to date, not been well understood but instead they are a cause for general concern...
November 2017: Environmental Research
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