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https://www.readbyqxmd.com/read/27916618/perceived-discrimination-associated-with-asthma-and-related-outcomes-in-minority-youth-the-gala-ii-and-sage-ii-studies
#1
Neeta Thakur, Nicolas E Barcelo, Luisa N Borrell, Smriti Singh, Celeste Eng, Adam Davis, Kelley Meade, Michael A LeNoir, Pedro C Avila, Harold J Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon Thyne, Jose R Rodriguez-Santana, Saunak Sen, Kirsten Bibbins-Domingo, Esteban Gonzalez Burchard
BACKGROUND: Asthma disproportionately affects minority populations and is associated with psychosocial stress, such as racial/ethnic discrimination. We aim to examine the association of perceived discrimination with having asthma and poor asthma control in African American and Latino youth. METHODS: We included African American (n=954), Mexican American (n=1086), other Latino (n=522), and Puerto Rican Islander (n=1025) youth (aged 8 to 21 years old) from the GALA II and SAGE II studies...
December 1, 2016: Chest
https://www.readbyqxmd.com/read/27908699/fast-methodology-for-the-determination-of-a-broad-set-of-antibiotics-and-some-of-their-metabolites-in-seafood
#2
Albert Serra-Compte, Diana Álvarez-Muñoz, Sara Rodríguez-Mozaz, Damià Barceló
The presence of antibiotics in seafood for human consumption may pose a risk for consumers. A methodology for the analysis of antibiotics in seafood based on QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction, followed by detection and quantification using liquid chromatography coupled to mass spectrometry was developed. The analytical method was evaluated for the determination of 23 antibiotics (including parent compounds and some metabolites) in fish, mussels and clams. Recoveries ranged between 30% and 70% for most of the compounds and method detection and quantification limits (MDLs and MQLs) were between 0...
November 28, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27894681/results-of-micronucleus-assays-with-individuals-who-are-occupationally-and-environmentally-exposed-to-mercury-lead-and-cadmium
#3
REVIEW
Armen Nersesyan, Michael Kundi, Monika Waldherr, Tahereh Setayesh, Miroslav Mišík, Georg Wultsch, Metka Filipic, Gustavo Rafael Mazzaron Barcelos, Siegfried Knasmueller
Millions of humans are exposed occupationally and environmentally to lead, mercury and cadmium compounds. Mercury compounds are less abundant but some of them belong to the most toxic chemicals which are known. We evaluated the literature to find out if these metals act in humans as genotoxic carcinogens and if their health effects can be predicted by use of micronucleus (MN) assays with lymphocytes and/or with other genotoxicity tests. Numerous studies showed that lead and mercury induce cancer in humans and also in animals, in vitro experiments with cultured cells indicate that they cause DNA damage via different molecular mechanisms including release of reactive oxygen species and interactions with DNA repair processes...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27889770/usefulness-of-discriminability-and-response-bias-indices-for-the-evaluation-of-recognition-memory-in-mild-cognitive-impairment-and-alzheimer-disease
#4
María Julieta Russo, Gabriela Cohen, Jorge Campos, Maria Eugenia Martin, María Florencia Clarens, Liliana Sabe, Ernesto Barcelo, Ricardo F Allegri
BACKGROUND: Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE: To evaluate the recognition memory performance by using a yes/no procedure to examine the effect of discriminability and response bias measures in amnestic mild cognitive impairment (a-MCI), AD dementia, and normal-aging subjects...
November 26, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27889212/study-of-the-effect-of-the-bacterial-and-fungal-communities-present-in-real-wastewater-effluents-on-the-performance-of-fungal-treatments
#5
Marina Badia-Fabregat, Daniel Lucas, Tero Tuomivirta, Hannu Fritze, Taina Pennanen, Sara Rodríguez-Mozaz, Damià Barceló, Glòria Caminal, Teresa Vicent
The use of the ligninolytic fungi Trametes versicolor for the degradation of micropollutants has been widely studied. However, few studies have addressed the treatment of real wastewater containing pharmaceutically active compounds (PhAC) under non-sterile conditions. The main drawback of performing such treatments is the difficulty for the inoculated fungus to successfully compete with the other microorganisms growing in the bioreactor. In the present study, several fungal treatments were performed under non-sterile conditions in continuous operational mode with two types of real wastewater effluent, namely, a reverse osmosis concentrate (ROC) from a wastewater treatment plant and a veterinary hospital wastewater (VHW)...
November 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27836183/neuronal-surface-antibodies-in-hiv-infected-patients-with-isolated-psychosis
#6
Vanessa Cunill, Susana Arboleya, Maria de Los Reyes Jiménez, Antoni Campins, Patricia Herbera, LLuïsa Mestre, Antonio Clemente, Maria Inés Barceló, Maria Leyes, Francesca Canellas, Maria Rosa Julià
Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort...
November 2, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27817833/analysis-of-organophosphorus-flame-retardants-in-environmental-and-biotic-matrices-using-on-line-turbulent-flow-chromatography-liquid-chromatography-tandem-mass-spectrometry
#7
Monica Giulivo, Ettore Capri, Ethel Eljarrat, Damià Barceló
A fast on-line analytical method based on turbulent flow chromatography (TFC) in combination with tandem mass spectrometry (MS-MS) has been applied for the analysis of fourteen organophosphorus flame retardants (OPFRs) in sediment and fish samples. Applying this technique, time-consuming sample preparation steps were eliminated. The extraction was performed by ultrasound liquid extraction for biota and by pressurized liquid extraction for sediments. After extraction, environmental and biotic extracts were directly injected to the chromatographic system and analytes were concentrated into the cleanup loading column...
October 17, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27816557/influence-of-magnesium-supplementation-on-movement-side-effects-related-to-typical-antipsychotic-treatment-in-rats
#8
Maikel Kronbauer, Vinicia Garzela Metz, Karine Roversi, Veronica Tironi Dias, Caren Tatiane de David Antoniazzi, Raquel Cristine da Silva Barcelos, Marilise E Burger
Chronic use of typical antipsychotic haloperidolis related to movement disturbances such as parkinsonism, akathisia and tardive dyskinesia which have been related to excitotoxicity in extrapyramidal brain areas, requiring their prevention and treatment. In the current study we evaluated the influence of the magnesium on prevention (for 28days before-), reversion (for 12days after-) and concomitant supplementation on haloperidol-induced movement disorders in rats. Sub-chronic haloperidol was related to orofacial dyskinesia (OD) and catalepsy development, increased generation of reactive species (RS) and levels of protein carbonyl (PC) in cortex, striatum and substantia nigra (SN) in all experimental protocols...
November 2, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27815255/chronic-allergic-pulmonary-inflammation-is-aggravated-in-angiotensin-1-7-mas-receptor-knockout-mice
#9
Giselle Santos Magalhães, Maria da Glória Rodrigues-Machado, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Robson Augusto Souza Santos, Luciola S Barcelos, Maria José Campagnole-Santos
Angiotensin-(1-7) [Ang-(1-7)]/Mas receptor pathway is currently recognized as a counterbalancing mechanism of the renin-angiotensin system in different pathophysiological conditions. We have previously described that treatment with Ang-(1-7) attenuates lung inflammation and remodeling in an experimental model of asthma. In the present study, we investigated whether lack of Mas receptor could alter the inflammatory response in a model of chronic allergic lung inflammation induced by ovalbumin (OVA). MasWT and MasKO mice were subjected to 4 doses of OVA (20µg/mice, i...
November 4, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27814544/chemical-and-toxicological-characterisation-of-anticancer-drugs-in-hospital-and-municipal-wastewaters-from-slovenia-and-spain
#10
Marina Isidori, Margherita Lavorgna, Chiara Russo, Michael Kundi, Bojana Žegura, Matjaž Novak, Metka Filipič, Miroslav Mišík, Siegfried Knasmueller, Miren López de Alda, Damià Barceló, Božo Žonja, Marjeta Česen, Janez Ščančar, Tina Kosjek, Ester Heath
Anticancer drugs are continuously released into hospital and urban wastewaters, where they, most commonly, undergo conventional treatment in wastewater treatment plants (WWTPs). Wastewaters contain complex mixtures of substances including parent compounds, their metabolites and transformation products (TPs). In this study, samples of hospital effluents and WWTP influents and effluents from Slovenia and Spain were analyzed for twenty-two selected anticancer drugs, their metabolites and transformation products...
October 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27810526/elimination-study-of-the-chemotherapy-drug-tamoxifen-by-different-advanced-oxidation-processes-transformation-products-and-toxicity-assessment
#11
Laura Ferrando-Climent, Rafael Gonzalez-Olmos, Alba Anfruns, Ignasi Aymerich, Lluis Corominas, Damià Barceló, Sara Rodriguez-Mozaz
Tamoxifen is a chemotherapy drug considered as recalcitrant contaminant (with low biodegradability in conventional activated sludge wastewater treatment), bioaccumulative, ubiquitous, and potentially hazardous for the environment. This work studies the removal of Tamoxifen from water by advanced oxidation processes, paying special attention to the formation of transformation products (TPs) and to the evolution of toxicity (using the Microtox(®) bioassay) during the oxidation processes. Five types of treatments were evaluated combining different technologies based on ozone, hydrogen peroxide and UV radiation: i) O3, ii) O3/UV, iii) O3/H2O2 (peroxone), iv) UV and v) UV/H2O2...
October 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/27799217/population-pharmacokinetics-and-pharmacogenetics-analysis-of-rilpivirine-in-hiv-1-infected-individuals
#12
Manel Aouri, Catalina Barcelo, Monia Guidi, Margalida Rotger, Matthias Cavassini, Cédric Hizrel, Thierry Buclin, Laurent A Decosterd, Chantal Csajka
BACKGROUND: Rilpivirine (RPV), the latest non nucleoside reverse transcriptase inhibitor active against HIV-1, is prescribed in a standard dosage of 25 mg once a day in combination with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF). The aim of this observational study was to characterize RPV pharmacokinetic profile, to quantify interpatient variability and to identify potential factors that could influence drug exposure. METHODS: RPV concentrations data were collected from HIV patients as part of routine therapeutic drug monitoring performed in our centre...
October 31, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27798274/placing-intracerebral-probes-to-optimise-detection-of-delayed-cerebral-ischemia-and-allow-for-the-prediction-of-patient-outcome-in-aneurysmal-subarachnoid-haemorrhage
#13
Yannick Tholance, Gleicy K Barcelos, Armand Perret-Liaudet, Edris Omar, Romain Carrillon, Sébastien Grousson, Thomas Lieutaud, Frédéric Dailler, Stéphane Marinesco
Cerebral microdialysis could be useful to detect delayed cerebral ischemia in aneurysmal subarachnoid haemorrhage patients. The optimal location of the probes, however, remains controversial. Here, we determined the vascular territories with the highest infarct risk in relation to aneurysm location to define probe implantation guidelines. These guidelines were retrospectively validated by studying the likelihood of probe to fall in a secondary infarct area, and by analysing their influence to predict patient outcome...
October 21, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27789470/topotecan-plus-carboplatin-versus-standard-therapy-with-paclitaxel-plus-carboplatin-pc-or-gemcitabine-plus-carboplatin-gc-or-pegylated-liposomal-doxorubicin-plus-carboplatin-pldc-a-randomized-phase-iii-trial-of-the-noggo-ago-study-group-ago-austria-and-geico
#14
J Sehouli, R Chekerov, A Reinthaller, R Richter, A Gonzalez-Martin, P Harter, H Woopen, E Petru, L C Hanker, E Keil, P Wimberger, P Klare, C Kurzeder, F Hilpert, A K Belau, A Zeimet, I Bover-Barcelo, U Canzler, S Mahner, W Meier
BACKGROUND: Randomized, phase III trial to evaluate safety and efficacy of topotecan and carboplatin (TC) compared with standard platinum-based combinations in platinum-sensitive recurrent ovarian cancer (ROC). PATIENTS AND METHODS: Patients were randomly assigned in a 1:1 ratio to the experimental TC arm (topotecan 0.75 mg/m(2)/ days 1-3 and carboplatin AUC 5 on day 3 every 3 weeks) or to one of the standard regimes [(PC) paclitaxel plus carboplatin; (GC) gemcitabine plus carboplatin; (PLDC) pegylated liposomal doxorubicin and carboplatin] which could be chosen by individual preference but before randomization...
October 26, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27789388/a-deep-insight-into-the-whole-transcriptome-of-midguts-ovaries-and-salivary-glands-of-the-amblyomma-sculptum-tick
#15
Higo Nasser Santanna Moreira, Rafael Mazioli Barcelos, Pedro Marcus Pereira Vidigal, Raphael Contelli Klein, Carlos Emmanuel Montandon, Talles Eduardo Ferreira Maciel, Juliana Fernandes Areal Carrizo, Paulo Henrique Costa de Lima, Adriano Carlos Soares, Maria Marlene Martins, Cláudio Mafra
No abstract text is available yet for this article.
October 24, 2016: Parasitology International
https://www.readbyqxmd.com/read/27775301/-is-there-appendiceal-stump-appendicitis
#16
A García Baglietto, C Barceló Cañellas, C Marhuenda Irastorza
INTRODUCTION: Stump appendicitis is the remaining appendicular tissue inflammation after a variable length of time. It is a very infrequent pathology with a paucity in pediatric publications, and given the fact that a delay in its diagnosis could lead to an increased morbidity, this is the reason of its clinical relevance. CLINICAL CASE: A 10 years old girl who had laparoscopic excision of a flemonous-gangrenous appendicitis and who 45 days after surgery showed new clinical symptoms compatible with a diagnosis of acute appendicitis...
October 10, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27771214/orthotic-use-for-cmc-osteoarthritis-variations-among-different-health-professionals-in-brazil
#17
Pedro H T Q de Almeida, Joy C MacDermid, Tatiana Barcelos Pontes, Clarissa Cardoso Dos Santos-Couto-Paz, Licia Maria H da Mota, João Paulo C Matheus
STUDY DESIGN: Cross-sectional descriptive study. INTRODUCTION: Osteoarthritis (OA) is the most prevalent musculoskeletal disease in the adult and older adult populations. The use of orthoses to stabilize the thumb's articular complex is one of the most common conservative management strategies. Despite substantial research about this topic, there is insufficient evidence about the optimal use of orthoses to inform clinical practice, contributing to practice variations within and across health professionals...
October 19, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27752238/ecamulticapa-effectiveness-of-double-layered-compression-therapy-for-healing-venous-ulcers-in-primary-care-a-study-protocol
#18
Carmen Folguera-Álvarez, Sofia Garrido-Elustondo, José Verdú-Soriano, Diana García-García-Alcalá, Mónica Sánchez-Hernández, Oscar German Torres-de Castro, Maria Luisa Barceló-Fidalgo, Olga Martínez-González, Lidia Ardiaca-Burgués, Carmen Solano-Villarrubia, Pilar Raquel Lebracón-Cortés, Carmen Molins-Santos, Mar Fresno-Flores, Maria Carmen Cánovas-Lago, Luisa Fernanda Benito-Herranz, Maria Teresa García-Sánchez, Olga Castillo-Pla, María Sol Morcillo-San Juan, Maria Begoña Ayuso-de la Torre, Pilar Burgos-Quintana, Ana López-Torres-Escudero, Gema Ballesteros-García, Piedad García-Cabeza, Maria Ángeles de Francisco-Casado, Milagros Rico-Blázquez
BACKGROUND: Chronic venous insufficiency, in its final stage can cause venous ulcers. Venous ulcers have a prevalence of 0.5 % to 0.8 % in the general population, and increases starting at 60 years of age. This condition often causes increased dependency in affected individuals, as well as a perceived reduced quality of life and family overload. Local Treating chronic venous ulcers has 2 components: topically healing the ulcer and controlling the venous insufficiency. There is evidence that compressive therapy favours the healing process of venous ulcers...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27745772/informed-participation-in-the-valencian-community-colorectal-cancer-screening-programme-from-a-gender-perspective
#19
Ana Molina-Barceló, Rosana Peiró-Pérez, Mercedes Vanaclocha, Guillermo Vallés, Laura Guaita, Dolores Salas
OBJECTIVE: To examine the factors that influence informed participation in a Colorectal Cancer Screening Programme (CRCSP) from a gender perspective. METHODS: Cross-sectional telephone survey directed to men and women invited to participate (2009-2010) in the Valencian Community CRCSP (Spain). SAMPLE SIZE: 785 subjects. OUTCOME VARIABLES: participation in CRCSP and being informed. Bivariate and multivariate analysis using logistic regression models (95% confidence interval [95%CI], p <0...
October 10, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27734509/zinc-hyperaccumulation-substitutes-for-defense-failures-beyond-salicylate-and-jasmonate-signaling-pathways-of-alternaria-brassicicola-attack-in-noccaea-caerulescens
#20
Berta Gallego, Soledad Martos, Catalina Cabot, Juan Barceló, Charlotte Poschenrieder
The hypothesis of metal defense as a substitute for a defective biotic stress signaling system in metal hyperaccumulators was tested using the pathosystem Alternaria brassicicola - Noccaea caerulescens under low (2 μM), medium (12 μM), and high (102 μM) Zn supply. Regardless the Zn supply, N. caerulescens responded to fungal attack with the activation of both HMA4 coding for a Zn transporter, and biotic stress signaling pathways. Salicylate, jasmonate, abscisic acid, and indoleacetic acid concentrations, as well as biotic stress marker genes (PDF1...
October 13, 2016: Physiologia Plantarum
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