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https://www.readbyqxmd.com/read/28724225/seasonal-variations-in-the-occurrence-of-perfluoroalkyl-substances-in-water-sediment-and-fish-samples-from-ebro-delta-catalonia-spain
#1
Emanuela Pignotti, Gemma Casas, Marta Llorca, Anil Tellbüscher, David Almeida, Enrico Dinelli, Marinella Farré, Damià Barceló
The main objective of this study was to assess the concentration levels and the seasonal variations of 13 poly- and perfluoroalkyl substances (PFASs) in different compartments (water, sediments and fish) of the Ebro Delta (NE Spain) and surrounding coastal areas. Perfluorooctanoic acid (PFOA) was the most frequently detected compound in waters and sediments. Perfluorocarboxylic acids (PFCAs) were the compounds found at the highest concentrations in water samples. On the other hand, sediments were more enriched in perfluorooctanesulfonate (PFOS) (range<1...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28721826/clinical-uses-of-melatonin-in-neurological-diseases-and-mental-and-behavioural-disorders
#2
Emilio J Sánchez-Barceló, Noemi R Revilla, María D Mediavilla, Carmen Martínez-Cué, Russel J Reiter
Melatonin is a molecule with numerous properties applicable to the treatment of neurological diseases. Among these properties are the following: potent scavenger of oxygen and nitrogen reactive species, anti-inflammatory features, immuno-enhancing nature, and modulation of circadian rhythmicity. Furthermore, low concentrations of melatonin are usually found in patients with neurological diseases and mental disorders. The positive results obtained in experimental models of diverse pathologies, including diseases of the nervous system (e...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28716492/unusual-presenting-manifestation-of-a-rare-polyposis-cowden-syndrome
#3
Luisa Adán Merino, Mercedes Aldeguer Martínez, Federico Álvarez Rodríguez, Marta Barceló López, Rocío Plaza Santos, Fátima Valentín Gómez
No abstract text is available yet for this article.
July 14, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28714411/pharmacology-and-literature-review-based-on-related-death-and-non-fatal-case-reports-of-the-benzofurans-and-benzodifurans-designer-drugs
#4
Bernardino Barceló Martín, Isabel Gomila
BACKGROUND: Benzofurans and benzodifurans are two groups of psychoactive substances that had originally been synthesized for research purpose. Benzofurans' structure is quite similar to the known recreational drug 3,4-methylenedioxymethamphetamine together with its active metabolite 3,4-methylenedioxyamphetamine. Benzodifurans are closely related to phenethylamines, but have more hallucinogens effects and much longer duration of action. This study aims to review the accessible evidence-based literature on benzofurans and benzodifurans pharmacology and toxicology...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28712918/topical-nitric-oxide-releasing-nanoparticles-are-effective-in-a-murine-model-of-dermal-trichophyton-rubrum-dermatophytosis
#5
Breanne Mordorski, Caroline Barcelos Costa-Orlandi, Ludmila M Baltazar, Leandro J Carreño, Angelo Landriscina, Jamie Rosen, Mahantesh Navati, Maria Jose Soares Mendes-Giannini, Joel M Friedman, Joshua D Nosanchuk, Adam J Friedman
Systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. To address this, we investigated topical nitric oxide-releasing nanoparticles (NO-np), which have been used against superficial fungal infections and bacterial abscesses. In addition to enhanced penetration and permeation conferred by nanoparticles, nitric oxide, a broad-spectrum multi-mechanistic antimicrobial agent, offers decreased likelihood of resistance development...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28710651/intoxication-caused-by-new-psychostimulants-analytical-methods-to-disclose-acute-and-chronic-use-of-benzofurans-and-ethylphenidate
#6
Bernardino Barceló, Isabel Gomila, Maria Concetta Rotolo, Emilia Marchei, Chrystalla Kyriakou, Simona Pichini, Carolina Roset, Miguel Ángel Elorza, Francesco Paolo Busardò
The acute and chronic toxicity of several new psychoactive substances (NPS) is unknown, and only little information is available on the pharmacology and toxicology, toxicokinetics, and detectability in body samples of such new compounds. We here propose analytical methods to disclose acute and chronic use of two types of new psychostimulants: benzofurans and ethylphenidate and we applied them to a real case of a subject attending Emergency Department with signs of acute intoxication due to psychotropic drug(s)...
July 15, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28704363/uniform-multidrug-therapy-for-leprosy-patients-in-brazil-u-mdt-ct-br-results-of-an-open-label-randomized-and-controlled-clinical-trial-among-multibacillary-patients
#7
Gerson Oliveira Penna, Samira Bührer-Sékula, Lígia Regina Sansigolo Kerr, Mariane Martins de Araújo Stefani, Laura Cunha Rodrigues, Marcelo Grossi de Araújo, Andrea Machado Coelho Ramos, Ana Regina Coelho de Andrade, Maurício Barcelos Costa, Patricia Sammarco Rosa, Heitor de Sá Gonçalves, Rossilene Cruz, Maurício Lima Barreto, Maria Araci de Andrade Pontes, Maria Lúcia Fernandes Penna
BACKGROUND: Leprosy control is based on early diagnosis and multidrug therapy. For treatment purposes, leprosy patients can be classified as paucibacillary (PB) or multibacillary (MB), according to the number of skin lesions. Studies regarding a uniform treatment regimen (U-MDT) for all leprosy patients have been encouraged by the WHO, rendering disease classification unnecessary. METHODOLOGY AND FINDINGS: An independent, randomized, controlled clinical trial conducted from 2007 to 2015 in Brazil, compared main outcomes (frequency of reactions, bacilloscopic index trend, disability progression and relapse rates) among MB patients treated with a uniform regimen/U-MDT (dapsone+rifampicin+clofazimine for six months) versus WHO regular-MDT/R-MDT (dapsone+rifampicin+clofazimine for 12 months)...
July 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28693448/high-cancer-mortality-for-us-born-latinos-evidence-from-california-and-texas
#8
Paulo S Pinheiro, Karen E Callahan, Scarlett Lin Gomez, Rafael Marcos-Gragera, Taylor R Cobb, Aina Roca-Barcelo, Amelie G Ramirez
BACKGROUND: Latinos born in the US, 36 million, comprise 65% of all US Latinos. Yet their cancer experience is nearly always analyzed together with their foreign-born counterparts, 19 million, who constitute a steady influx of truly lower-risk populations from abroad. To highlight specific cancer vulnerabilities for US-born Latinos, we compare their cancer mortality to the majority non-Latino white (NLW) population, foreign-born Latinos, and non-Latino blacks. METHODS: We analyzed 465,751 cancer deaths from 2008 to 2012 occurring among residents of California and Texas, the two most populous states, accounting for 47% of US Latinos...
July 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28692925/role-of-the-adjunctive-antimicrobial-photodynamic-therapy-to-periodontal-treatment-at-plasmatic-oxidative-stress-and-vascular-behavior
#9
L M Barin, R C S Barcelos, L T Vey, F M Pillusky, V M Palma, K Z Kantorski, M E Bürger, R M Maciel, C C Danesi
BACKGROUND: To evaluate for the first time in vivo the effects of methylene blue (MB) photosensitizer dissolved in ethanol in antimicrobial photodynamic therapy (aPDT) as adjuvant periodontal treatment, at plasmatic oxidative stress and vascular behavior in rat model. METHODS: Wistar rats were divided into negative control (NC, no periodontitis) and positive control (PC, with periodontitis, without any treatment). The other groups had periodontitis and were treated with scaling and root planing (SRP); SRP+aPDT+MB dissolved in water (aPDT I); SRP+aPDT+MB dissolved in ethanol (aPDT II)...
June 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28691554/uptake-and-metabolism-of-carbamazepine-cbz-by-clam-ruditapes-decussatus-and-its-effects-in-biochemical-responses
#10
Abdelhafidh Khazri, Ali Mezni, Hassen Khazri, Badreddine Sellami, Jaume Aceña, Sandra Pérez, Ethel Eljarrat, Damià Barceló, Hamouda Beyrem, Ezzeddine Mahmoudi
Laboratory experiments were carried out to assess uptake and metabolism of the epilepsy drug, carbamazepine and its consequent biological responses in marine clam (Ruditapes decussatus) a model non-target organism in ecotoxicology. Clams were exposed to two nominal concentrations (C1= 30 µg/L and C2= 50 µg/L) of CBZ for a maximum period of 14 days. Analysis of CBZ and their metabolites in clam and water after exposure to two nominal concentrations of the pharmaceutical drug were performed using UPLC-HRMS analysis...
July 10, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28691149/12th-annual-lc-ms-ms-workshop-on-environmental-applications-and-food-safety-5-6-july-2016-barcelona-spain
#11
Mira Petrovic, Damià Barceló
No abstract text is available yet for this article.
July 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28690768/endoscopic-recommendations-for-colorectal-cancer-screening-and-surveillance-in-patients-with-inflammatory-bowel-disease-review-of-general-recommendations
#12
REVIEW
Jose María Huguet, Patricia Suárez, Luis Ferrer-Barceló, Lucía Ruiz, Ana Monzó, Ana Belén Durá, Javier Sempere
Screening for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are: (1) Who should be offered screening for CRC? and (2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28672086/circulating-branched-chain-amino-acids-in-children-with-obstructive-sleep-apnea
#13
Antonia Barceló, Josep Miquel Bauça, José Antonio Peña-Zarza, Daniel Morell-Garcia, Aina Yáñez, Gerardo Pérez, Javier Piérola, Nuria Toledo, Mónica de la Peña
INTRODUCTION: The effects of obstructive sleep apnea (OSA) on the metabolic system are not well understood, especially in children. Recent studies have provided evidence of the modulation of insulin action by branched-chain amino acids (BCAAs) and suggested novel mechanistic relationships between glucose and amino acid metabolic pathways. We hypothesized that plasma BCAA levels may serve as biomarkers of insulin resistance and metabolic dysfunction in children with OSA. METHODS: A polysomnography was conducted for the diagnosis of OSA in 90 snoring children, in a tertiary hospital...
July 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28670737/a-human-scfv-antibody-that-targets-and-neutralizes-high-molecular-weight-pathogenic-amyloid-%C3%AE-oligomers
#14
Adriano Sebollela, Erika N Cline, Izolda Popova, Kevin Luo, Xiaoxia Sun, Jay Ahn, Milena A Barcelos, Vanessa N Bezerra, Natalia M Lyra E Silva, Jason Patel, Nathalia R Pinheiro, Lei A Qin, Josette M Kamel, Anthea Weng, Nadia DiNunno, Adrian M Bebenek, Pauline T Velasco, Kirsten L Viola, Pascale N Lacor, Sergio T Ferreira, William L Klein
Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have been identified, both in vitro and in vivo, ranging from dimers to 24mers and higher-order oligomers. However, there is no consensus in the literature regarding which AβO species are most germane to AD pathogenesis. Antibodies capable of specifically recognizing defined subpopulations of AβOs would be a valuable asset in the identification, isolation, and characterization of AD-relevant AβO species...
July 3, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28664339/metabolite-profiling-of-carbamazepine-and-ibuprofen-in-solea-senegalensis-bile-using-high-resolution-mass-spectrometry
#15
Jaume Aceña, Sandra Pérez, Peter Eichhorn, Montserrat Solé, Damià Barceló
The widespread occurrence of pharmaceuticals in the aquatic environment has raised concerns about potential adverse effects on exposed wildlife. Very little is currently known on exposure levels and clearance mechanisms of drugs in marine fish. Within this context, our research was focused on the identification of main metabolic reactions, generated metabolites, and caused effects after exposure of fish to carbamazepine (CBZ) and ibuprofen (IBU). To this end, juveniles of Solea senegalensis acclimated to two temperature regimes of 15 and 20 °C for 60 days received a single intraperitoneal dose of these drugs...
June 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28658740/fungal-treatment-for-the-removal-of-endocrine-disrupting-compounds-from-reverse-osmosis-concentrate-identification-and-monitoring-of-transformation-products-of-benzotriazoles
#16
Marta Llorca, Marina Badia-Fabregat, Sara Rodríguez-Mozaz, Glòria Caminal, Teresa Vicent, Damià Barceló
The removal of 27 endocrine-disrupting compounds and related compounds (suspect effect) from a reverse osmosis concentrate using an alternative decontamination method based on a fungal treatment involving Trametes versicolor was assessed. In addition to chemical analysis, the toxicity of the treated water during the treatment was monitored using a bioluminescence inhibition test and estrogenic and anti-estrogenic tests. The compounds 1H-benzotriazole (BTZ) and two tolyltriazoles (TTZs), 4-methyl-1H-benzotriazole (4-MBTZ) and 5-methyl-1H-benzotriazole (5-MBTZ), were present in the reverse osmosis concentrate at the highest concentrations (7...
June 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28658338/profile-of-skin-cancer-in-pomeranian-communities-of-the-state-of-esp%C3%A3-rito-santo
#17
Patrícia Henriques Lyra Frasson, Danilo Schwab Duque, Estanrley Barcelos Pinto, Giulia Cerutti Dalvi, Sammy Zogheib Madalon, Tarcizo Afonso Nunes, Paulo Roberto Merçon DE-Vargas
Objectives: to evaluate the profile of skin cancer in Pomeranian communities of the State of Espírito Santo, composed of descendants of European immigrants, regarding gender and age at diagnosis, lesion size and histological type. Method: we studied histopathological reports of 3,781 patients operated between 2000 and 2010, with resection of 4,881 lesions. We assessed histological type, lesion size, age and gender of the patients at diagnosis and their correlations in the 11-year period...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28639014/sediments-as-a-sink-for-uv-filters-and-benzotriazoles-the-case-study-of-upper-igua%C3%A3-u-watershed-curitiba-brazil
#18
Alinne Mizukawa, Daniel Molins-Delgado, Júlio César Rodrigues de Azevedo, Cristóvão Vicente Scapulatempo Fernandes, Silvia Díaz-Cruz, Damià Barceló
Ingredients in home and personal care products, including UV filters and benzotriazoles, are high production volume chemicals extensively used in our daily life, despite several studies revealed their potential eco-toxicity and endocrine-disrupting capacity. Due to some features, such as high lipophilicity, low degradability, and persistence of many of these compounds, sediments can be considered a sink for them in the aquatic environment. In the present study, nine organic UV filters and three benzotriazoles were investigated for the first time in sediments from four urban rivers in Brazil...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28621937/surface-termination-of-fe3o4-111-films-studied-by-co-adsorption-revisited
#19
X Li, J Paier, J Sauer, F Mirabella, E Zaki, F Ivars-Barceló, S Shaikhutdinov, H-J Freund
Although the (111) surface of Fe3O4 (magnetite) has been investigated for more than 20 years, substantial controversy remains in the literature regarding the surface termination proposed based on structural and adsorption studies. The present article provides density functional theory results that allow to rationalize experimental results of infrared reflection-absorption spectroscopy and temperature-programmed desorption studies on CO adsorption, thus leading to a unified picture in which the Fe3O4(111) surface is terminated by a (1)/4 monolayer of tetrahedrally coordinated Fe(3+) ions on top of a close-packed oxygen layer as previously determined by low energy electron diffraction...
June 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28612521/could-modafinil-prevent-psychostimulant-addiction-an-experimental-study-in-rats
#20
Verônica Tironi Dias, Luciana Taschetto Vey, Higor Zuquetto Rosa, Lívia Ferraz D'avila, Raquel Cristine Silva Barcelos, Marilise Escobar Burger
Addiction is a serious health problem which leads to general social impairment. The period of adolescence plays a significant role in drug abuse liability. Psychostimulants, such as modafinil (MOD), are majorly used by teenagers seeking improvements in cognition, which contributes to its indiscriminate use. This study aimed to investigate the influence of MOD (64 mg/kg by gavage, once a day) treatment during adolescence [post-natal day (PND) 28-42] on amphetamine (AMPH, 4 mg/kg i.p.)-conditioned place preference (CPP) in early adulthood (PND 60)...
June 14, 2017: Basic & Clinical Pharmacology & Toxicology
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