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A García Baglietto, C Barceló Cañellas, C Marhuenda Irastorza
INTRODUCTION: Stump appendicitis is the remaining appendicular tissue inflammation after a variable length of time. It is a very infrequent pathology with a paucity in pediatric publications, and given the fact that a delay in its diagnosis could lead to an increased morbidity, this is the reason of its clinical relevance. CLINICAL CASE: A 10 years old girl who had laparoscopic excision of a flemonous-gangrenous appendicitis and who 45 days after surgery showed new clinical symptoms compatible with a diagnosis of acute appendicitis...
October 10, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Pedro H T Q de Almeida, Joy C MacDermid, Tatiana Barcelos Pontes, Clarissa Cardoso Dos Santos-Couto-Paz, Licia Maria H da Mota, João Paulo C Matheus
STUDY DESIGN: Cross-sectional descriptive study. INTRODUCTION: Osteoarthritis (OA) is the most prevalent musculoskeletal disease in the adult and older adult populations. The use of orthoses to stabilize the thumb's articular complex is one of the most common conservative management strategies. Despite substantial research about this topic, there is insufficient evidence about the optimal use of orthoses to inform clinical practice, contributing to practice variations within and across health professionals...
October 19, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Carmen Folguera-Álvarez, Sofia Garrido-Elustondo, José Verdú-Soriano, Diana García-García-Alcalá, Mónica Sánchez-Hernández, Oscar German Torres-de Castro, Maria Luisa Barceló-Fidalgo, Olga Martínez-González, Lidia Ardiaca-Burgués, Carmen Solano-Villarrubia, Pilar Raquel Lebracón-Cortés, Carmen Molins-Santos, Mar Fresno-Flores, Maria Carmen Cánovas-Lago, Luisa Fernanda Benito-Herranz, Maria Teresa García-Sánchez, Olga Castillo-Pla, María Sol Morcillo-San Juan, Maria Begoña Ayuso-de la Torre, Pilar Burgos-Quintana, Ana López-Torres-Escudero, Gema Ballesteros-García, Piedad García-Cabeza, Maria Ángeles de Francisco-Casado, Milagros Rico-Blázquez
BACKGROUND: Chronic venous insufficiency, in its final stage can cause venous ulcers. Venous ulcers have a prevalence of 0.5 % to 0.8 % in the general population, and increases starting at 60 years of age. This condition often causes increased dependency in affected individuals, as well as a perceived reduced quality of life and family overload. Local Treating chronic venous ulcers has 2 components: topically healing the ulcer and controlling the venous insufficiency. There is evidence that compressive therapy favours the healing process of venous ulcers...
2016: BMC Nursing
Ana Molina-Barceló, Rosana Peiró-Pérez, Mercedes Vanaclocha, Guillermo Vallés, Laura Guaita, Dolores Salas
OBJECTIVE: To examine the factors that influence informed participation in a Colorectal Cancer Screening Programme (CRCSP) from a gender perspective. METHODS: Cross-sectional telephone survey directed to men and women invited to participate (2009-2010) in the Valencian Community CRCSP (Spain). SAMPLE SIZE: 785 subjects. OUTCOME VARIABLES: participation in CRCSP and being informed. Bivariate and multivariate analysis using logistic regression models (95% confidence interval [95%CI], p <0...
October 10, 2016: Gaceta Sanitaria
Berta Gallego, Soledad Martos, Catalina Cabot, Juan Barceló, Charlotte Poschenrieder
The hypothesis of metal defense as a substitute for a defective biotic stress signaling system in metal hyperaccumulators was tested using the pathosystem Alternaria brassicicola - Noccaea caerulescens under low (2 μM), medium (12 μM), and high (102 μM) Zn supply. Regardless the Zn supply, N. caerulescens responded to fungal attack with the activation of both HMA4 coding for a Zn transporter, and biotic stress signaling pathways. Salicylate, jasmonate, abscisic acid, and indoleacetic acid concentrations, as well as biotic stress marker genes (PDF1...
October 13, 2016: Physiologia Plantarum
Puebla Cassini-Vieira, Mariane Felipetto, Leandro Barbosa Prado, Thiago Verano-Braga, Silvia Passos Andrade, Robson A S Santos, Mauro Martins Teixeira, Maria Elena de Lima, Adriano M C Pimenta, Luciola Silva Barcelos
We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we investigated whether Ts14 could modulate key events (neovascularization, inflammatory cell recruitment, and extracellular matrix deposition) of the fibrovascular tissue, induced by polyether-polyurethane sponge implants in mice...
October 11, 2016: Peptides
O Maiques, A Macià, S Moreno, C Barceló, M Santacana, A Vea, J Herreros, S Gatius, E Ortega, J Valls, B J Chen, D Llobet-Navas, X Matias-Guiu, C Cantí, R M Marti
BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca(2+) channels (TTCs) are upregulated in human melanoma and play an important role on cell proliferation. The aim of this study was to describe for the first time in formalin-fixed-paraffin-embedded tissue the immunoexpression of TT-Cs in biopsies of normal skin, acquired melanocytic nevi and melanoma, in order to evaluate their role in melanomagenesis and/or tumor progression, their utility as prognostic markers and their possible use in targeted therapies...
October 8, 2016: British Journal of Dermatology
Clara Sze-Man Tang, Hongsheng Gui, Ashish Kapoor, Jeong-Hyun Kim, Berta Luzón-Toro, Anna Pelet, Grzegorz Burzynski, Francesca Lantieri, Man-Ting So, Courtney Berrios, Hyoung Doo Shin, Raquel M Fernández, Thuy-Linh Le, Joke B G M Verheij, Ivana Matera, Stacey S Cherny, Priyanka Nandakumar, Hyun Sub Cheong, Guillermo Antiñolo, Jeanne Amiel, Jeong-Meen Seo, Dae-Yeon Kim, Jung-Tak Oh, Stanislas Lyonnet, Salud Borrego, Isabella Ceccherini, Robert M W Hofstra, Aravinda Chakravarti, Hyun-Young Kim, Pak Chung Sham, Paul K H Tam, Maria-Mercè Garcia-Barceló
Hirschsprung disease (HSCR) is the most common cause of neonatal intestinal obstruction. It is characterized by the absence of ganglia in the nerve plexuses of the lower gastrointestinal tract. So far, three common disease-susceptibility variants at the RET, SEMA3 and NRG1 loci have been detected through genome-wide association studies (GWAS) in Europeans and Asians to understand its genetic etiologies. Here we present a trans-ethnic meta-analysis of 507 HSCR cases and 1191 controls, combining all published GWAS results on HSCR to fine-map these loci and narrow down the putatively causal variants to 99% credible sets...
October 3, 2016: Human Molecular Genetics
Marta Llorca, Marinella Farré, Ethel Eljarrat, Sílvia Díaz-Cruz, Sara Rodríguez-Mozaz, Daniel Wunderlin, Damià Barcelo
Although it is known that emerging contaminants are widespread all over the globe, there is a gap of information about their distribution in some geographical areas, such as Latin America. This bibliographic work reviews the available literature about the presence of organic emerging contaminants in Latin American freshwater and marine biota between 2002 and 2016 and includes 23 works from Argentina, Brazil, Chile, Colombia, Mexico and Nicaragua. In particular, the manuscript overviews the occurrence of continuously present contaminants such as pharmaceuticals, personal care products, pyrethroid insecticides as well as the new groups of persistent organic pollutants (POPs), the halogenated flame retardants and the perfluoroalkyl substances...
September 26, 2016: Environmental Toxicology and Chemistry
Joan Bestard-Escalas, Jone Garate, Albert Maimó-Barceló, Roberto Fernández, Daniel Horacio Lopez, Sergio Lage, Rebeca Reigada, Sam Khorrami, Daniel Ginard, José Reyes, Isabel Amengual, José A Fernández, Gwendolyn Barceló-Coblijn
Membrane lipids are gaining increasing attention in the clinical biomarker field, as they are associated with different pathologic processes such as cancer or neurodegenerative diseases. Analyzing human colonoscopic sections by matrix assisted laser/desorption ionization (MALDI) mass spectrometry imaging techniques, we identified a defined number of lipid species changing concomitant to the colonocyte differentiation and according to a quite simple mathematical expression. These species felt into two lipid families tightly associated in signaling: phosphatidylinositols and arachidonic acid-containing lipids...
September 20, 2016: Biochimica et Biophysica Acta
Jonathan M Barcelo
PURPOSE: This study aimed to compare the perception of the academic learning environment between medical laboratory science students and nursing students at Saint Louis University, Baguio City, Philippines. METHODS: A cross-sectional survey research design was used to measure the perceptions of the participants. A total of 341 students from the Department of Medical Laboratory Science, School of Natural Sciences, and the School of Nursing answered the Dundee Ready Education Environment Measure (DREEM) instrument from April to May 2016...
2016: Journal of Educational Evaluation for Health Professions
G S Dolci, H Z Rosa, R C S Barcelos, L T Vey, A Santos, P DallaVechia, C Bizzi, M A Cunha, B Baldisserotto, M E Burger
This study investigated if hypoxia acclimation modifies the hematological and oxidative profiles in tissues of Mn-exposed silver catfish (Rhamdia quelen), and if such modifications persist upon subsequent reoxygenation. Silver catfish acclimated to hypoxia (~3mgL(-1)) for 10days and subsequently exposed to Mn (~8.1mgL(-1)) for additional 10days exhibited lower Mn accumulation in plasma, liver and kidney, even after reoxygenation, as compared to normoxia-acclimated fish. Hypoxia acclimation increased per se red blood cells count and hematocrit, suggesting adaptations under hypoxia, while the reoxygenation process was also related to increased hematocrit and hemoglobin per se...
September 17, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
María N Pizzi, Albert Roque, Hug Cuéllar-Calabria, Nuria Fernández-Hidalgo, Ignacio Ferreira-González, María T González-Alujas, Alberto Igual-Barceló, David Garcia-Dorado, Benito Almirante, Joan Castell-Conesa, Manuel Escobar Amores, Pilar Tornos, Santiago Aguadé-Bruix
No abstract text is available yet for this article.
October 2016: JACC. Cardiovascular Imaging
Pedro Henrique Tq de Almeida, Joy MacDermid, Tatiana Barcelos Pontes, Clarissa Cardoso Dos Santos-Couto-Paz, João Paulo Chieregato Matheus
BACKGROUND: Orthoses are a well-known intervention for the treatment of thumb osteoarthritis; however, there is a multitude of orthotic designs and not enough evidence to support the efficacy of specific models. OBJECTIVE: To examine the influence of different orthoses on pain, hand strength, and hand function of patients with thumb osteoarthritis. STUDY DESIGN: Literature review. METHODS: A scoping literature review of 14 publications reporting orthotic interventions for patients with thumb osteoarthritis was conducted...
September 9, 2016: Prosthetics and Orthotics International
Mirian de Freitas DalBen, Elisa Teixeira Mendes, Maria Luisa Moura, Dania Abdel Rahman, Driele Peixoto, Sania Alves Dos Santos, Walquiria Barcelos de Figueiredo, Pedro Vitale Mendes, Leandro Utino Taniguchi, Francisco Antonio Bezerra Coutinho, Eduardo Massad, Anna Sara Levin
OBJECTIVE To reduce transmission of carbapenem-resistant Enterobacteriaceae (CRE) in an intensive care unit with interventions based on simulations by a developed mathematical model. DESIGN Before-after trial with a 44-week baseline period and 24-week intervention period. SETTING Medical intensive care unit of a tertiary care teaching hospital. PARTICIPANTS All patients admitted to the unit. METHODS We developed a model of transmission of CRE in an intensive care unit and measured all necessary parameters for the model input...
November 2016: Infection Control and Hospital Epidemiology
Nícolas de Castro Campos Pinto, Puebla Cassini-Vieira, Elaine Maria de Souza-Fagundes, Lucíola Silva Barcelos, Maria Christina Marques Nogueira Castañon, Elita Scio
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Pereskia aculeata Miller (Cactaceae), known as Barbados gooseberry, are used as emollients and to treat skin wounds and inflammatory process in Brazilian traditional medicine. AIM OF THE STUDY: This study investigated the topical wound healing activity of gels containing the methanol extract (ME) and hexane fraction (HF) of the leaves of this plant in a model of excisional wound healing in mice. MATERIAL AND METHODS: Mice were anesthetized and excisional skin wounds were performed using a circular metal punch of 5 mm diameter...
September 3, 2016: Journal of Ethnopharmacology
Samira Benhammou, Leticia Heras-González, Diana Ibáñez-Peinado, Carla Barceló, May Hamdan, Ana M Rivas, Miguel Mariscal-Arcas, Fatima Olea-Serrano, Celia Monteagudo
Fruit, vegetables, cereals, and olive oil are common elements of the Mediterranean diet (MD), but each country in the Mediterranean basin has its own gastronomic customs influenced by socio-cultural, religious, and economic factors. This study compared the dietary habits of three Mediterranean populations with different cultures and lifestyles, a total of 600 adults (61.9% females) between 25 and 70 yrs from Spain, Morocco, and Palestine. All participants completed a self administered questionnaire, including sociodemographic and anthropometric items, a validated semi-quantitative food frequency questionnaire adapted to the foods consumed in each country, and three 24-h recalls...
September 2, 2016: Appetite
José Portugal, Francisca Barceló
DNA-binding compounds are of extraordinary importance in medicine, accounting for a substantial portion of antitumor drugs in clinical usage. However, their mechanisms of action remain sometimes incompletely understood. This review critically examines two broad classes of molecules that bind noncovalently to DNA: intercalators and groove binders. Intercalators bind to DNA by inserting their chromophore moiety between two consecutive base pairs, whereas groove binders fit into the grooves of DNA. Noncovalent DNA-interactive drugs can recognize certain supramolecular DNA structures such as the G-quadruplexes found in telomeres and in numerous gene promoters, and they can act as topoisomerase I and II poisons...
September 2, 2016: Current Medicinal Chemistry
D Rivas, A Ginebreda, A Elosegi, J Pozo, S Pérez, C Quero, D Barceló
Characterization of river ecosystems must take into consideration both structural and functional aspects. For the latter, a convenient and simple approach for routine monitoring is based on the decomposition of organic matter measured in terms of breakdown of natural organic substrates like leaf litter, wood sticks. Here we extended the method to a synthetic organic material using polymer probes characterized by MALDI-TOF/MS. We first characterized several commercial available polymers, and finally selected polycaprolactonediol 1250 (PCP 1250), a polyester oligomer, as the most convenient for further studies...
August 27, 2016: Science of the Total Environment
Fernando Bermejo San José, Mireia Barceló Barceló-Bru, Miquel Ribera-Pibernat, José Luís Poveda-Andrés, Luciano Sanromán-Álvarez
OBJECTIVE: Patient compliance in chronic inflammatory diseases is essential to achieve treatment effectiveness. The study objective is to develop a recommendations document for healthcare professionals to encourage treatment compliance. METHODS: A sequential methodology was followed: 1. Systematic review of EBM Reviews, Embase and MedLine without time restriction of interventions on compliance in chronic inflammatory diseases. Studies were selected according to previously defined criteria (confirmed diagnosis of chronic inflammatory disease of patients included, assessment of adherence interventions and experimental study design)...
September 2016: Farmacia Hospitalaria
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