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https://www.readbyqxmd.com/read/28641285/role-of-glycyrrhizin-in-the-reduction-of-inflammation-in-diabetic-kidney-disease
#1
Vikram Thakur, Syeda Nargis, Mayra Gonzalez, Swetak Pradhan, Daniel Terreros, Munmun Chattopadhyay
BACKGROUND: Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes. Recent evidence suggests chronic inflammation to be one of the causal factors of DKD. The mechanisms entailed are not completely elucidated except that a variety of cytokines play a major role in this process. High mobility group box 1 (HMGB1) is a pro-inflammatory toll-like receptor-4 (TLR4)-binding cytokine that is involved in inflammation-associated gene expression. This investigation was designed to assess the involvement of HMGB1, TLR-4, and nuclear factor (NF)-κB in the development of DKD and to evaluate that whether blocking HMGB1 by its natural inhibitor Glycyrrhizin (GLC) can reduce the progression of the disease...
June 23, 2017: Nephron
https://www.readbyqxmd.com/read/28641127/deep-brain-stimulation-of-subthalamic-nucleus-helps-in-improving-late-phase-motor-planning-in-parkinson-s-disease
#2
Patil Ashlesh, Sood Sanjay Kumar, Kochhar Kanwal Preet, Goyal Vinay
OBJECTIVE: Deep brain stimulation of subthalamic nucleus (DBS-STN) is a well-accepted treatment for Parkinson's disease (PD) but its effect on motor planning in the disease is yet unclear. This study examines the effect of switching the stimulation ON and OFF on components of bereitschaftspotentials in PD. PATIENTS AND METHODS: Scalp bereitschaftspotentials were recorded during self-paced right wrist extensions at Fz, Cz, Pz, C3 and C4 sites in patients on DBS-STN plus medications (DBS-STN group) as treatment modality or on medications only (Med group) and compared with age matched healthy controls...
June 15, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28640907/accelerometer-measured-levels-of-moderate-to-vigorous-intensity-physical-activity-and-sedentary-time-in-children-and-adolescents-with-chronic-disease-a-systematic-review-and-meta-analysis
#3
Rabha Elmesmari, John J Reilly, Anne Martin, James Y Paton
CONTEXT: Moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) are important for child and adolescent health. OBJECTIVE: To examine habitual levels of accelerometer measured MVPA and ST in children and adolescents with chronic disease, and how these levels compare with healthy peers. METHODS: Data sources: An extensive search was carried out in Medline, Cochrane library, EMBASE, SPORTDiscus and CINAHL from 2000-2017. Study selection: Studies with accelerometer-measured MVPA and/or ST (at least 3 days and 6 hours/day to provide estimates of habitual levels) in children 0-19 years of age with chronic diseases but without co-morbidities that would present major impediments to physical activity...
2017: PloS One
https://www.readbyqxmd.com/read/28637230/perceived-stress-and-its-relationship-with-chronic-conditions-and-multimorbidity-among-229-293-community-dwelling-adults-in-44-low-and-middle-income-countries
#4
Davy Vancampfort, Ai Koyanagi, Philip B Ward, Nicola Veronese, André F Carvalho, Marco Solmi, James Mugisha, Simon Rosenbaum, Marc De Hert, Brendon Stubbs
This study assessed the association of chronic conditions and multimorbidity with perceived stress among community-dwelling adults in 44 low- and middle-income countries. Data were analyzed from the World Health Survey (2002-2004) including 229,293 adults. A perceived stress score [range 0 (lowest stress) -100 (highest stress)] was computed based on two questions from the Perceived Stress Scale. Eleven chronic conditions were assessed. Multivariable linear regression analyses were conducted to explore the associations...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28637125/bilateral-movements-increase-sustained-extensor-force-in-the-paretic-arm
#5
Nyeonju Kang, James H Cauraugh
PURPOSE: Muscle weakness in the extensors poststroke is a common motor impairment. Unfortunately, research is unclear on whether bilateral movements increase extensor force production in the paretic arm. This study investigated sustained force production while stroke individuals maximally extended their wrist and fingers on their paretic arm. Specifically, we determined isometric force production in three conditions: (a) unilateral paretic arm, (b) unilateral nonparetic arm, and (c) bilateral (both arms executing the same movement simultaneously)...
February 6, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28637107/malignant-melanoma-of-the-anus-found-during-routine-colonoscopy-in-ulcerative-colitis
#6
Kwang Il Seo, Won Moon, Sung Eun Kim, Moo In Park, Seun Ja Park
Inflammatory bowel disease (IBD) is characterized by recurrent or chronic inflammation of the gastrointestinal tract, which results in increased risk of developing cancer. Anorectal malignant melanoma is often misdiagnosed as either hemorrhoids or benign anorectal conditions in inflammatory bowel disease. Therefore, the overall prognosis and survival of IBD are poor. To date, the best treatment strategy remains controversial. Only early diagnosis and complete excision yield survival benefit. Here, we report a 64-year-old woman with ulcerative colitis, who was found to have anal malignant melanoma on routine colonoscopy...
June 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28637094/acclimation-responses-to-high-light-by-guazuma-ulmifolia-lam-malvaceae-leaves-at-different-stages-of-development
#7
Anderson Kikuchi Calzavara, Juliana Silva Rocha, Geovana Lourenço, Karina Sanada, Cristiano Medri, Edmilson Bianchini, José Antonio Pimenta, Renata Stolf-Moreira, Halley Caixeta Oliveira
The recomposition of deforested environments requires the prior acclimation of seedlings to full sun in nurseries. Seedlings can overcome excessive light either through the acclimation of pre-existing fully expanded leaves or through the development of new leaves that are acclimated to the new light environment. Here, we compared the acclimation capacity of mature (MatL, fully expanded at the time of transfer) and newly expanded leaves (NewL, expanded after the light shift) of Guazuma ulmifolia Lam. (Malvaceae) seedlings to high light...
June 21, 2017: Plant Biology
https://www.readbyqxmd.com/read/28637074/-nutrition-in-cancer-effective-in-prevention-and-treatment
#8
Jann Arends
Nutritional effects on cancer occurrence and on treatment outcome in cancer patients may depend on food preferences and on the quantity of foods supplied. However, it has been difficult to reliably show beneficial effects of specific dietary concepts on cancer incidence. On the other hand, obesity as a result of chronic overfeeding has been linked firmly to an increased risk of a number of cancers as well as on cancer recurrence after treatment. Metabolic consequences of obesity and other components of the metabolic syndrome may be responsible for inducing and/or promoting cancer growth and should be antagonized by regular moderate physical activity in healthy subjects and in cancer survivors...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28636546/changes-of-peripheral-lymphocyte-subsets-and-cytokine-environment-during-ageing-and-deteriorating-gastrointestinal-tract-health-status
#9
Jing Wang, Guodong Yang, Dongfang Wang, Kuiliang Liu, Yongchao Ma, Hong Liu, Jing Wu, Min Fang
Human immune senescence accompanies with the physical and physiological frailty. The functional change and shift of NK, NKT and T cell subsets by ageing have been widely studied. However, it remains largely unclear how the ageing and disease conditions affect the distribution of lymphocytes. In the present study, 233 subjects with age range from 20 to 87 year old, including healthy people, people with chronic gastrointestinal tract disease or cancers were investigated. We found that the proportion of NK cells, CD8+ T cells and NKT cells remained relatively unchanged with ageing...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636457/notch-signaling-in-lung-diseases
#10
Jiehan Jiang, Kui Xiao, Ping Chen
NOTCH is a fundamental signaling system that regulates normal embryonic development and tissue homeostasis in adult life. NOTCH receptor is a single-pass transmembrane protein normally triggered via direct cell-to-cell contact, in which NOTCH ligands bind the extracellular domain of the receptor, inducing γ-secretase cleavage and release of intracellular domain. The intracellular domain binds to the transcriptional effector RBPJκ to activate transcription of target genes that regulate cell differentiation, patterning, and morphogenesis during embryonic development and adult life...
June 21, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28636272/development-of-biotic-ligand-model-based-freshwater-aquatic-life-criteria-for-lead-following-us-environmental-protection-agency-guidelines
#11
David K DeForest, Robert C Santore, Adam C Ryan, Brian G Church, M Jasim Chowdhury, Kevin V Brix
The US Environmental Protection Agency's (USEPA's) current ambient water quality criteria (AWQC) for lead (Pb) in freshwater were developed in 1984. The criteria are adjusted for hardness, but more recent studies have demonstrated that other parameters, especially dissolved organic carbon (DOC) and pH, have a much stronger influence on Pb bioavailability. These recent studies have been used to support development of a biotic ligand model (BLM) for Pb in freshwater, such that acute and chronic Pb toxicity can be predicted over a wide range of water chemistry conditions...
June 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28635909/-chronic-obstructive-pulmonary-disease-concurrent-with-metabolic-syndrome-pathophysiological-and-clinical-features
#12
A V Budnevsky, E S Ovsyannikov, N B Labzhania
Chronic obstructive pulmonary disease (COPD) still remains a serious public health problem, which is a common cause of disability and death in the able-bodied population. Furthermore, the number of patients with metabolic syndrome (MS) is steadily increasing worldwide. Recently, there is also an increase in the number of patients with COPD concurrent with MS, which is a mutually confounding risk factor for concomitant cardiovascular disease and adversely affects prognosis in these patients. Systemic subclinical inflammation is a common link between COPD and the components of MS...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28635907/-the-problem-of-obstructive-sleep-apnea-syndrome-in-asthmatic-patients
#13
E G Sheludko, D E Naumov, Yu M Perelman, V P Kolosov
Asthma and obstructive sleep apnea syndrome (OSAS) are one of the most common chronic respiratory diseases. These have common risk factors that include obesity, gastroesophageal reflux disease (GERD) and impaired nasal breathing (allergic rhinitis, sinusitis). At the same time, experimental evidence demonstrates common pathophysiological mechanisms of these diseases, such as involvement in the process of the respiratory tract, a systemic inflammatory response, and implementation of neuromechanical reflexes...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28635547/-healthcare-seems-to-vary-a-lot-a-focus-group-study-among-parents-of-children-with-severe-allergy
#14
Birgitta Lagercrantz, Åsa Persson, Inger Kull
BACKGROUND: Living with an allergic disease has consequences for both affected children and their families. The aim of this qualitative study was to gain deeper knowledge of what life is like for families of children with severe allergic disease, in order to improve care and thereby reduce the consequences of living with a chronic disease. METHODS: Four focus group interviews were performed with Swedish parents of children, aged 6-11 and 12-16 years, with severe allergic disease (from one or more allergic conditions, such as food allergy/eczema/hay fever/asthma)...
February 22, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28635538/clomipramine-trial-for-treatment-resistant-persistent-genital-arousal-disorder-a-case-series
#15
Ejder Akgun Yildirim, Munevver Hacioglu Yildirim, Elif Carpar, Irmak Sarac
INTRODUCTION: Treatment of persistent genital arousal disorder (PGAD), as a chronic and disabling condition, implicates substantial compelling complexities. METHODS: In this case series, seven women diagnosed with PGAD who were referred to the Sexual Dysfunction Unit of Psychotherapy Outpatient Clinic of Bakirkoy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey between 2006 and 2009 were included. All patients were previously resistant to other antidepressants, antipsychotics and antiepileptics...
March 3, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28635482/diagnosis-and-management-of-myasthenia-gravis
#16
Christopher Barber
Myasthenia gravis is a rare long-term neurological condition that is characterised by fluctuating skeletal muscle weakness and fatigue, as well as respiratory difficulties. It is both an acquired autoimmune disease and a chronic neuromuscular disorder. Because of its rarity, myasthenia gravis is relatively unknown and may be unfamiliar to many nurses. While there are various types of myasthenia, this article focuses on myasthenia gravis, exploring its symptoms, diagnosis and treatment, and examining the nurse's role in managing the condition...
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635346/effect-of-drug-related-cues-on-response-inhibition-through-abstinence-a-pilot-study-in-male-heroin-abstainers
#17
Bobo Su, Ling Yang, Grace Y Wang, Sha Wang, Shaomei Li, Hua Cao, Yan Zhang
BACKGROUND: Chronic heroin use can cause a deficit of inhibitory function, leading to a loss of control over drug use. Exposure to drug-related cues is considered as one of the contributing factors. However, it is unclear whether there are dynamic changes on the effect of drug-related cues on response inhibition following prolonged abstinence. OBJECTIVE: The present study investigated the effect of drug-related cues on response inhibition in heroin abstainers at different abstinent phases...
February 17, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28635299/prevalence-and-geographic-variations-of-polypharmacy-among-west-virginia-medicaid-beneficiaries
#18
Xue Feng, Xi Tan, Brittany Riley, Tianyu Zheng, Thomas K Bias, James B Becker, Usha Sambamoorthi
BACKGROUND: West Virginia (WV) residents are at high risk for polypharmacy given its considerable chronic disease burdens. OBJECTIVE: To evaluate the prevalence, correlates, outcomes, and geographic variations of polypharmacy among WV Medicaid beneficiaries. METHODS: In this cross-sectional study, we analyzed 2009-2010 WV Medicaid fee-for-service (FFS) claims data for adults aged 18-64 (N=37,570). We defined polypharmacy as simultaneous use of drugs from five or more different drug classes on a daily basis for at least 60 consecutive days in one year...
June 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28635197/depression-anxiety-and-chronic-pain-in-patients-with-chronic-obstructive-pulmonary-disease-the-influence-of-breath
#19
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi
Chronic obstructive pulmonary disease (COPD) is a major public health problems, causing significant mortality and morbidity in the world. It is a complex and progressive disease, characterized by chronic inflammation and dysfunction of the respiratory airways. The article reviews the available information on the potential role of the diaphragm in this disease. The purpose is to identify a potential correlation between symptoms such as depression, anxiety and chronic pain, frequently observed in COPD, with the activity of the diaphragm...
May 25, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28635191/impact-of-a-nutrition-educational-program-in-a-group-of-type-2-diabetes-patients-already-involved-in-a-wider-group-care-plan-and-not-achieving-complete-target-an-observational-study
#20
Anna Comba, Alessandra Ardizzone, Laura Leto, Mauro Feola
Type 2 diabetes is one of the most frequent chronic degenerative diseases in the world (5.4% in Italy); it has many chronic consequences with a significant impact either on expectation or quality of life. About 80-90% of type 2 diabetes patients is either overweight or obese, condition that can cause many more negative consequences than in individuals in the same conditions but with normal weight. The aim of the research is to assess if diabetic people who cannot reach the goals of glycemic control, good eating habits and weight loss can eventually obtain, with an individualized care plan, long lasting improvements...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
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