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https://www.readbyqxmd.com/read/29241279/does-early-artificial-rupture-of-membranes-speed-labor-in-preterm-inductions
#1
Melissa M Parrish, Spencer G Kuper, Victoria C Jauk, Sima H Baalbaki, Alan T Tita, Lorie M Harper
No abstract text is available yet for this article.
December 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29240650/oxytocin-use-in-labor-legal-implications
#2
Susan Drummond
Oxytocin is one of the most commonly used medications in obstetrics and has been associated with claims of negligence in cases of adverse outcomes. Errors involving intravenous oxytocin administration for induction or augmentation of labor are most commonly dose related and include failure to avoid or treat tachysystole or failure to asses or treat a fetal heart rate pattern indicative of disruption in oxygenation. Clinicians should be knowledgeable regarding pharmacokinetics of oxytocin and the effect of uterine contractions on fetal oxygenation as well as safe titration of oxytocin to achieve the desired effect while minimizing harm...
December 13, 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29237138/characteristics-associated-with-induction-of-labor-and-delivery-route-among-primiparous-women-with-term-deliveries-in-the-listening-to-mothers-iii-study
#3
Meliha Salahuddin, Christina Davidson, David L Lakey, Divya A Patel
BACKGROUND: Induction of labor (IOL) is increasingly common in the United States, yet characteristics associated with IOL among primiparous women delivering at term are not well understood. MATERIALS AND METHODS: Data from the Listening to Mothers III study, a survey of women aged 18-45 with singleton deliveries in U.S. hospitals in 2011-2012, were utilized. Weighted logistic regression models examined predictors of IOL among 924 primiparous women with term deliveries...
December 13, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29230337/prenatal-diagnosis-of-a-segmental-small-bowel-volvulus-with-threatened-premature-labor
#4
Barbara Monard, Nicolas Mottet, Rajeev Ramanah, Didier Riethmuller
Fetal primary small bowel volvulus is extremely rare but represents a serious life-threatening condition needing emergency neonatal surgical management to avoid severe digestive consequences. We report a case of primary small bowel volvulus with meconium peritonitis prenatally diagnosed at 27 weeks and 4 days of gestation during threatened premature labor with reduced fetal movements. Ultrasound showed a small bowel mildly dilated with thickened and hyperechogenic intestinal wall, with a typical whirlpool configuration...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229362/french-validation-and-adaptation-of-the-grobman-nomogram-for-prediction-of-vaginal-birth-after-cesarean-delivery
#5
Jean-Baptiste Haumonte, Mélina Raylet, Marie Christophe, Franck Mauviel, Armelle Bertrand, Raoul Desbriere, Claude d'Ercole
OBJECTIVE: To validate Grobman nomogram for predict vaginal birth after cesarean delivery (VBAC) in a French population and adapt it. STUDY DESIGN: Multicenter retrospective study of maternal and obstetric factors associated with VBAC between May 2012 and May 2013 in 6 maternity. External validation and adaptation of the prenatal and intrapartum Grobman nomograms for vaginal birth prediction after cesarean delivery in a French cohort RESULTS: The study included 523 women with previous cesarean deliveries; 70% underwent a trial of labor for a subsequent delivery (n=367) with a success rate of 65% (n=240)...
December 8, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29224730/a-validated-calculator-to-estimate-risk-of-cesarean-after-an-induction-of-labor-with-an-unfavorable-cervix
#6
Lisa D Levine, Katheryne L Downes, Samuel Parry, Michal A Elovitz, Mary D Sammel, Sindhu K Srinivas
BACKGROUND: Induction of labor occurs in more than 20% of pregnancies, which equates to approximately 1 million women undergoing an induction in the United States annually. Regardless of how common inductions are, our ability to predict induction success is limited. Although multiple risk factors for a failed induction have been identified, risk factors alone are not enough to quantify an actual risk of cesarean for an individual woman undergoing a cesarean. OBJECTIVE: The objective of this study was to derive and validate a prediction model for cesarean after induction with an unfavorable cervix and to create a web-based calculator to assist in patient counseling...
December 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29224196/diagnostic-accuracy-of-posterior-cervical-angle-and-cervical-length-in-the-prediction-of-successful-induction-of-labor
#7
Akram M Al-Adwy, Sherin M Sobh, Doaa S Belal, Eman F Omran, Amr Hassan, Ahmed H Saad, Mai M Afifi, Adel M Nada
OBJECTIVE: To determine the accuracy of the posterior cervical angle (PCA) compared with the cervical length and the Bishop score in predicting the outcome of induction of labor (IOL). METHODS: The present prospective observational study included IOL candidates who had their PCA and cervical length assessed by transvaginal ultrasonography and the Bishop score at the Obstetrics and Gynecology Department, Kasr El-Aini Hospital, Cairo University, Cairo, Egypt, between April 1 and July 31, 2017...
December 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29215519/foley-plus-oxytocin-compared-with-oxytocin-for-induction-after-membrane-rupture-a-randomized-controlled-trial
#8
A Dhanya Mackeen, Danielle E Durie, Monique Lin, Christopher K Huls, Emma Qureshey, Michael J Paglia, Haiyan Sun, Anthony Sciscione
OBJECTIVE: To evaluate the use of a transcervical Foley catheter plus oxytocin infusion compared with oxytocin infusion alone for labor induction and cervical ripening in women 34 weeks of gestation or greater with prelabor rupture of membranes. METHODS: This is a randomized, multicenter trial of women with a live, singleton gestation at 34 weeks of gestation or greater with prelabor rupture of membranes, an unfavorable cervical examination (less than 2 cm or 80% effaced), and no contraindication to labor...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215514/misoprostol-with-foley-bulb-compared-with-misoprostol-alone-for-cervical-ripening-a-randomized-controlled-trial
#9
Zainab Al-Ibraheemi, Lois Brustman, Brianne E Bimson, Natalie Porat, Barak Rosenn
OBJECTIVE: To test the hypothesis that cervical ripening using a combination of misoprostol and a transcervical Foley bulb leads to delivery within a shorter time compared with misoprostol alone. METHODS: This randomized controlled trial was offered to women admitted for cervical ripening. Inclusion criteria were gestational age 37 weeks or greater with intact membranes, singleton fetus, cephalic presentation, and Bishop score 6 or less. Exclusion criteria included, among others, prior uterine surgery, ruptured membranes, and any contraindication to vaginal delivery...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215512/term-elective-induction-of-labor-and-pregnancy-outcomes-among-obese-women-and-their-offspring
#10
Cassandra M Gibbs Pickens, Michael R Kramer, Penelope P Howards, Martina L Badell, Aaron B Caughey, Carol J Hogue
OBJECTIVE: To evaluate whether elective induction of labor between 39 through 41 weeks of gestation, as compared with expectant management, is associated with reduced cesarean delivery and other adverse outcomes among obese women and their offspring. METHODS: We conducted a retrospective cohort study using the 2007-2011 California Linked Patient Discharge Data-Birth Cohort File of 165,975 singleton, cephalic, nonanomalous deliveries to obese women. For each gestational week (39-41), we used multivariable logistic regression models, stratified by parity, to assess whether elective induction of labor or expectant management was associated with lower odds of cesarean delivery and other adverse outcomes...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29212131/predicting-vaginal-delivery-in-nulliparous-women-undergoing-induction-of-labor-at-term
#11
T Kawakita, U M Reddy, C C Huang, T C Auguste, D Bauer, R T Overcash
No abstract text is available yet for this article.
December 6, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29208680/subtle-modifications-to-oxytocin-produce-ligands-that-retain-potency-and-improved-selectivity-across-species
#12
Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R Deuis, Han Sheng Chiu, Nathan J Palpant, Margaret O'Brien, Terry J Smith, Susan Wray, Inga D Neumann, Christian W Gruber, Richard J Lewis, Paul F Alewood
Oxytocin and vasopressin mediate various physiological functions that are important for osmoregulation, reproduction, cardiovascular function, social behavior, memory, and learning through four G protein-coupled receptors that are also implicated in high-profile disorders. Targeting these receptors is challenging because of the difficulty in obtaining ligands that retain selectivity across rodents and humans for translational studies. We identified a selective and more stable oxytocin receptor (OTR) agonist by subtly modifying the pharmacophore framework of human oxytocin and vasopressin...
December 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/29206066/magnesium-induces-preconditioning-of-the-neonatal-brain-via-profound-mitochondrial-protection
#13
Gabriella Koning, Anna-Lena Leverin, Syam Nair, Leslie Schwendimann, Joakim Ek, Ylva Carlsson, Pierre Gressens, Claire Thornton, Xiaoyang Wang, Carina Mallard, Henrik Hagberg
Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring but the mechanism behind this protection is unclear, limiting its effective, safe clinical implementation. Previous studies suggest that MgSO4 is not neuroprotective if administered during or after the insult, so we hypothesised that MgSO4 induces preconditioning in the immature brain. Therefore, we administered MgSO4 at various time-points before/after unilateral hypoxia-ischemia (HI) in seven-day-old rats...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29203813/comparison-of-single-and-double-balloon-catheters-for-labor-induction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Raed Salim, Naama Schwartz, Noah Zafran, Sivan Zuarez-Easton, Gali Garmi, Shabtai Romano
OBJECTIVE: There is a paucity of head-to-head randomized trials that compare single- and double-balloon catheters, and the results of the available data in terms of time from catheter insertion to delivery and delivery mode are mixed. This meta-analysis of randomized controlled trials compares the efficacy of single- and double-balloon catheters in women undergoing labor induction. STUDY DESIGN: Searches were made in MEDLINE, EMBASE, PubMed, ClinicalTrials.gov, and the Cochrane Library from inception through June 2016...
December 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29200473/effect-of-premature-rupture-of-membranes-on-induction-of-labor-a-historical-cohort-study
#15
Sven Kehl, Christel Weiss, Ulf Dammer, Friederike Baier, Florian Faschingbauer, Matthias W Beckmann, Marc Sütterlin, Jutta Pretscher
Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM group); the primary outcome measure was the cesarean section rate...
November 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#16
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29194963/simultaneous-detection-of-protein-and-mrna-in-jurkat-and-kg-1a-cells-by-mass-cytometry
#17
Anastasia Mavropoulos, Bedilu Allo, Mingxiao He, Emily Park, Daniel Majonis, Olga Ornatsky
Mass cytometry uniquely enables high-dimensional single-cell analysis of complex populations. This recently developed technology is based on inductively coupled time-of-flight mass spectrometry for multiplex proteomic analysis of more than 40 markers per cell. The ability to characterize the transcriptome is critical for the understanding of disease pathophysiology, medical diagnostics, and drug discovery. Current techniques allowing the in situ detection of transcripts in single cells are limited to a small number of simultaneous targets and are generally tedious and labor-intensive...
November 30, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29185054/vacuum-extraction-in-low-birth-weight-%C3%A2-2500%C3%A2-g-neonates
#18
Amir Aviram, Eran Ashwal, Liran Hiersch, Yariv Yogev
PURPOSE: To evaluate the impact of vacuum extraction on birth injuries among low birth weight neonate (2000-2499 g). METHODS: Retrospective cohort study of women with singleton pregnancies > 34 weeks, birth weight of 2000-3500 g, undergoing vacuum extraction, between 2007 and 2014. Outcomes were compared between neonates who weighed 2000-2499 g and 2500-3500 g. RESULTS: Out of 62,102 deliveries, 5064 (8.2%) met the inclusion criteria, of which 269 (5...
November 28, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29169973/-maternal-death-by-venous-thromboembolic-disease
#19
M Rossignol, E Morau, M Dreyfus
Pregnancy and postpartum are very high-risk periods for venous thromboembolism events (TEE), which seems to extend far beyond the classical 6-8 weeks after childbirth. Pulmonary embolism (PE) is one of the 3 main causes of direct maternal death in western countries. Between 2010 an 2012 in France, 24 deaths were related to PE giving a maternal mortality ratio of 1/100,000, which is not different from the former report (2007-2009). PE is responsible of 9% of maternal deaths, in equal position with postpartum hemorrhage and amniotic fluid embolism...
November 20, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29162743/akap95-mediated-nuclear-anchoring-of-pka-mediates-cortisol-induced-ptgs2-expression-in-human-amnion-fibroblasts
#20
Jiangwen Lu, Wangsheng Wang, Yabing Mi, Chuyue Zhang, Hao Ying, Luyao Wang, Yawei Wang, Leslie Myatt, Kang Sun
Phosphorylation of the transcription factors cyclic adenosine monophosphate response element-binding protein (CREB) and signal transducer and activator of transcription 3 (STAT3) by protein kinase A (PKA) is required for the cortisol-induced production of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in human amnion fibroblasts, which critically mediates human parturition (labor). We found that PKA was confined in the nucleus by A-kinase-anchoring protein 95 (AKAP95) in amnion fibroblasts and that this localization was key to the cortisol-induced expression of PTGS2, the gene encoding COX-2...
November 21, 2017: Science Signaling
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