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https://www.readbyqxmd.com/read/28431302/quality-of-life-in-survivors-of-oropharyngeal-cancer-a%C3%A2-systematic-review-and-meta-analysis-of-1366-patients
#1
REVIEW
Sanne Høxbroe Michaelsen, Christian Grønhøj, Jacob Høxbroe Michaelsen, Jeppe Friborg, Christian von Buchwald
Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is rapidly increasing in incidence and has a favourable prognosis compared with HPV-negative disease. Current combined therapies include significant risks of morbidity for the growing group of survivors. This systematic review and meta-analysis investigates how treatment affects quality of life (QoL) in survivors of oropharyngeal cancer. PubMed, EMBASE and the Cochrane Library were systematically searched for all studies reporting patient-assessed QoL at least 1 year after treatment for OPC...
April 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28424453/comorbid-human-immunodeficiency-virus-hiv-and-muscle-specific-kinase-musk-myasthenia-gravis-a-case-report-and-literature-review
#2
Michael Sherpa, Ravi K Metai, Viki Kumar, Tinu Hirachan, Kawser U Ahmed, Sharon J Atkinson
BACKGROUND HIV infections with concomitant immunologically-mediated disorders have been frequently described but there has been little research on the association between HIV and myasthenia gravis. MuSK myasthenia gravis coexisting with HIV is an even a rarer entity and can occur as a part of immune restoration disease. We report the case of a patient with asymptomatic HIV infection who presented with new-onset MuSK myasthenia gravis. CASE REPORT A 44-year-old African-American woman with HIV since 2004 and on highly active antiretroviral therapy (HAART) presented to the ED with complains of double vision and difficulty swallowing for 2 weeks...
April 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28419723/characteristics-and-outcomes-of-alk-non-small-cell-lung-cancer-patients-in-korea
#3
Sung Hee Lim, Kyung Ah Yoh, Jong Seok Lee, Myung-Ju Ahn, Yu Jung Kim, Se Hyun Kim, Jie Zhang, Dony Patel, Elyse Swallow, Andrew Kageleiry, Philip Galebach, Dongyeol Lee, Karen Stein, Ravi Degun, Keunchil Park
AIM: This study aimed to describe characteristics, treatment patterns and survival among Korean patients diagnosed with locally advanced or metastatic anaplastic lymphoma kinase (ALK)+ non-small cell lung cancer (NSCLC). METHODS: A retrospective patient chart review was conducted in major cancer centers in Korea in 2014-2015. Participating physicians reviewed patient charts and reported characteristics, treatment patterns, clinician-defined progression-free survival (PFS) and overall survival (OS) of ALK+ locally advanced or metastatic NSCLC patients...
April 16, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28414663/not-another-acs-rule-out
#4
S Preston, R Nelson, M Watts, D Smith, T Dewenter, D Spruill
CASE: A 50 year old African-American woman with diabetes, hypertension, and hyperlipidemia presented with progressively worsening retro-sternal chest pain, exacerbated by activity and relieved by rest. She also endorsed a thirty-pound unintentional weight loss, and dysphagia. She was dysarthric with left-sided Bell's Palsy and a palpable left axillary lymph node. She had been evaluated at several hospitals in the previous months for similar typical chest pain. Her troponin values were normal, and an EKG showed T-wave inversions in leads I and aVL...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28411963/using-a-knowledge-based-planning-solution-to-select-patients-for-proton-therapy
#5
Alexander R Delaney, Max Dahele, Jim P Tol, Ingrid T Kuijper, Ben J Slotman, Wilko F A R Verbakel
BACKGROUND AND PURPOSE: Patient selection for proton therapy by comparing proton/photon treatment plans is time-consuming and prone to bias. RapidPlan™, a knowledge-based-planning solution, uses plan-libraries to model and predict organ-at-risk (OAR) dose-volume-histograms (DVHs). We investigated whether RapidPlan, utilizing an algorithm based only on photon beam characteristics, could generate proton DVH-predictions and whether these could correctly identify patients for proton therapy...
April 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28391413/self-expanding-metal-stents-improve-swallowing-and-maintain-nutrition-during-neoadjuvant-therapy-for-esophageal-cancer
#6
Zachary L Smith, Jason E Gonzaga, George B Haasler, Elizabeth M Gore, Kulwinder S Dua
BACKGROUND: Patients with locally advanced esophageal cancer can have significant dysphagia. Nutritional support during neoadjuvant therapy is often delivered via nasoenteric or percutaneous feeding tubes. These approaches do not allow for per-oral feeding. AIMS: Evaluate the safety and efficacy of fully covered self-expanding metal esophageal stents for nutritional support during neoadjuvant therapy. METHODS: This was a pilot, prospective study at a single tertiary center...
April 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28383846/-a-case-of-swallow-syncope
#7
P Trinco, B Falque, A-C Stilman, K Windhausen
Syncope accounts for nearly 5 % of the emergency intake causes. Swallow syncope is a rare form of cardio-neurogenic syncope. Less than a hundred cases were reported since its first description in the mid-18th century. We present the case of an 83-year-old patient with recurrent syncope occurring during meals. Telemetry monitoring revealed a severe bradycardia with complete AV block and a pause of 8 seconds. A dual chamber pacemaker was implanted and the syncopal episodes were abolished. We shall briefly review the diagnostic methods, mechanisms, and therapy of swallow syncope...
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28379595/hepatotoxicity-induced-by-greater-celandine-chelidonium-majus-l-a-review-of-the-literature
#8
F Pantano, G Mannocchi, E Marinelli, S Gentili, S Graziano, F P Busardò, N M di Luca
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper. Identification of significant scientific literature was performed via the following research databases: Cochrane Central, Google Scholar, EMBASE, Medline, Science Direct, Scopus, Web of Science, using the following keywords: "Chelidonium majus", "greater celandine", "Hepatotoxicity", "Liver" "Injury", "Toxicity" individually investigated and then again in association...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28372952/the-elipse-balloon-a-swallowable-gastric-balloon-for-weight-loss-not-requiring-sedation-anesthesia-or-endoscopy-a-pilot-study-with-12-month-outcomes
#9
Ioannis Raftopoulos, Andreas Giannakou
BACKGROUND: The Elipse Balloon is a swallowable gastric balloon for weight loss that can be deployed without the use of endoscopy or anesthesia. This study aims to report on 12-month safety and efficacy outcomes. SETTING: Private hospital, Athens, Greece. METHODS: This was a prospective, nonrandomized open trial. Twelve patients between 18 and 64 years of age with a body mass index (BMI) of 27.0 to 40.0 kg/m(2) were enrolled. The Elipse capsule is swallowed with water and its location in the stomach is confirmed by x-ray...
February 21, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28366681/obstructive-sleep-apnoea-and-the-role-of-tongue-reduction-surgery-in-children-with-beckwith-wiedemann-syndrome
#10
REVIEW
Christopher M Cielo, Kelly A Duffy, Aesha Vyas, Jesse A Taylor, Jennifer M Kalish
Beckwith-Wiedemann syndrome (BWS) is a rare paediatric overgrowth disorder. Associated macroglossia is a feature of many children with BWS and is felt to be a risk factor for obstructive sleep apnoea (OSA). Sleep-disordered breathing is highly variable in this population. The relationship between degree of macroglossia or other genotypic or phenotypic factors and OSA severity has not been established. The natural history of OSA in this population is unknown; a variety of conservative and surgical therapies have been used to treat OSA in children with BWS but none have been studied systematically...
February 24, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28365065/infantile-hemangiopericytoma-of-the-tongue-efficacy-of-ex-utero-intrapartum-treatment-procedure-and-combined-modality-therapy
#11
Takenori Ogawa, Ryo Ishii, Daiki Ozawa, Takeshi Rikiishi, Hajime Usubuchi, Mika Watanabe, Yoshimichi Imai, Kenichi Sato, Masatoshi Saito, Yoji Sasahara, Tadashi Matsuda, Shigeo Kure, Yukio Katori
Here we present an extremely rare case of giant infantile hemangiopericytoma (HPC) of the tongue diagnosed prenatally by fetal ultrasonography and MR imaging. Due to airway stenosis, the patient was delivered by the ex utero intrapartum treatment (EXIT) procedure at 36 weeks of pregnancy. Initial diagnosis was infantile hemangioma based on physical examination, diagnostic imaging and the high incidence of hemangioma. The tumor was resistant to conservative treatments. Due to severe tumor hemorrhage, the nutrient vessel was embolized by endovascular treatment on the 73th day after birth...
March 29, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28361972/pabpn1-gene-therapy-for-oculopharyngeal-muscular-dystrophy
#12
A Malerba, P Klein, H Bachtarzi, S A Jarmin, G Cordova, A Ferry, V Strings, M Polay Espinoza, K Mamchaoui, S C Blumen, J Lacau St Guily, V Mouly, M Graham, G Butler-Browne, D A Suhy, C Trollet, G Dickson
Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant, late-onset muscle disorder characterized by ptosis, swallowing difficulties, proximal limb weakness and nuclear aggregates in skeletal muscles. OPMD is caused by a trinucleotide repeat expansion in the PABPN1 gene that results in an N-terminal expanded polyalanine tract in polyA-binding protein nuclear 1 (PABPN1). Here we show that the treatment of a mouse model of OPMD with an adeno-associated virus-based gene therapy combining complete knockdown of endogenous PABPN1 and its replacement by a wild-type PABPN1 substantially reduces the amount of insoluble aggregates, decreases muscle fibrosis, reverts muscle strength to the level of healthy muscles and normalizes the muscle transcriptome...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28361201/swallowing-function-after-continuous-neuromuscular-electrical-stimulation-of-the-submandibular-region-evaluated-by-high-resolution-manometry
#13
Michael Jungheim, Christoph Schubert, Simone Miller, Martin Ptok
Although neuromuscular electrical stimulation (NMES) is increasingly used in dysphagia therapy, patient responses to NMES are inconsistent and conflicting results have been reported. This, together with a lack of information about the effects of NEMS on the swallowing process, has led to an ongoing debate about its impact on swallowing function. In order to address this, we set out to (i) collect baseline information on the physiological effects of NMES on the complex pharyngeal phase of swallowing and (ii) to compare two different stimulation protocols...
March 30, 2017: Dysphagia
https://www.readbyqxmd.com/read/28356653/effects-of-electrical-stimulation-combined-with-dysphagia-therapy-in-elderly-individual-with-oropharyngeal-dysphagia-a-case-study
#14
Doo-Ho Lee, Ji-Su Park, Seung-Woong Lee, Jong-Bae Choi
[Purpose] The purpose of the present study was to investigate the effects of dysphagia therapy in an old man with difficulty swallowing in the oral and pharyngeal phases. [Subjects and Methods] The subject was a 72-year-old man with no history of neurological disorders. He was admitted to local hospital because of the complaint of swallowing difficulty. The interventions performed were electrical stimulation and conventional dysphagia therapy. We assessed the tongue and lip muscle strengths. Swallowing function was evaluated by using the videofluoroscopic dysphagia and penetration-aspiration scales...
March 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28349345/photodynamic-inactivation-of-paracoccidioides-brasiliensis-helps-the-outcome-of-oral-paracoccidiodomycosis
#15
Letícia F M Dos Santos, Nathália B Melo, Marina L de Carli, Ana Carolina S C Mendes, Giulia Maria A C Bani, Liana M Verinaud, Eva Burger, Gabriel de Oliveira I Moraes, Alessandro A C Pereira, Maísa R L Brigagão, João Adolfo C Hanemann, Felipe F Sperandio
The antifungal drug therapy often employed to treat paracoccidiodomycosis (PCM), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. In addition, PCM compromises the oral health of patients by leading to oral lesions that are very painful and disabling. In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28341407/comparison-of-endoscopic-laser-therapy-and-self-expanding-metal-stents-for-palliation-in-patients-with-non-resectable-oesophageal-carcinoma
#16
R J Drummond, D G Vass, K Robertson, C Sharp, S Gibson
BACKGROUND: There are currently limited data on the comparative success of endoscopic laser therapy (NLT) and self expanding metal stents (SEMS) as palliative measures in patients with non-resectable oesophageal cancer. This study aims to assess and compare the outcomes of these methods of endoscopic palliation. METHODS: Patients with non-curative oesophageal/gastro-oesophageal cancers with dysphagia were identified prospectively and consented to swallow assessment and follow-up...
March 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28339136/eosinophilic-oesophagitis-phenotypes-ready-for-primetime
#17
REVIEW
Dan Atkins, Glenn T Furuta, Chris A Liacouras, Jonathan M Spergel
Eosinophilic Oesophagitis (EoE) is one of the most common causes of reflux like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids or dilation. In the last several years, recent clinical and translational research have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggests that various phenotypes may also exist in patients with EoE...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28337660/topgear-a-randomized-phase-iii-trial-of-perioperative-ecf-chemotherapy-with-or-without-preoperative-chemoradiation-for-resectable-gastric-cancer-interim-results-from-an-international-intergroup-trial-of-the-agitg-trog-eortc-and-cctg
#18
Trevor Leong, B Mark Smithers, Karin Haustermans, Michael Michael, Val Gebski, Danielle Miller, John Zalcberg, Alex Boussioutas, Michael Findlay, Rachel L O'Connell, Jaclyn Verghis, David Willis, Tomas Kron, Melissa Crain, William K Murray, Florian Lordick, Carol Swallow, Gail Darling, John Simes, Rebecca Wong
BACKGROUND: Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding preoperative chemoradiation to perioperative ECF will improve survival; however, the safety and feasibility of preoperative chemoradiation have yet to be determined. METHODS: TOPGEAR is an international phase III trial in which patients with adenocarcinoma of the stomach were randomized to perioperative ECF alone or with preoperative chemoradiation...
March 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28336550/the-effect-of-intravenous-corticotropin-releasing-hormone-administration-on-esophageal-sensitivity-and-motility-in-health
#19
Charlotte Broers, Chloé Melchior, Lukas Van Oudenhove, Tim Vanuytsel, Brecht Van Houtte, Charlotte Scheerens, Nathalie Rommel, Jan F Tack, Ans Pauwels
BACKGROUND: Esophageal hypersensitivity is important in gastro-esophageal reflux disease (GERD) patients refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. METHODS: Esophageal sensitivity to thermal, mechanical, electrical and chemical stimuli was assessed in 14 healthy subjects after placebo or CRH (100μg IV)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28319481/application-of-telepractice-for-head-and-neck-cancer-management-a-review-of-speech-language-pathology-service-models
#20
Elizabeth C Ward, Laurelie R Wall, Clare L Burns, Bena Cartmill, Anne J Hill
PURPOSE OF REVIEW: Head and neck cancer (HNC) is a complex and heterogeneous disease, requiring specialist intervention from a multidisciplinary team including speech language pathology (SLP). Unfortunately, multiple patient and service-related challenges exist which currently limit equitable access to SLP support for all individuals. This review highlights the existing evidence for different telepractice models designed to help patients and services optimize management of swallowing and communication disorders arising from HNC...
March 17, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
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