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https://www.readbyqxmd.com/read/29781748/pediatric-sloughing-esophagitis-a-case-report-and-discussion
#1
Lulu Sun, Christina A Hickey, Brendan R Harris, Horacio M Maluf, Mai He
BACKGROUND: Sloughing esophagitis is an uncommon entity with an unclear pathogenesis characterized by desquamating sheets of squamous mucosa. It has been associated with bullous dermatologic disorders, other autoimmune diseases and has been most commonly reported in elderly, debilitated individuals on multiple medications. CASE REPORT: We report sloughing esophagitis in a previously healthy 17 year-old girl. While the initial trigger of her esophagitis is unclear, she improved with proton pump inhibitor therapy and swallowed fluticasone, with complete resolution after 6 months...
May 21, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29768519/influence-of-growth-hormone-replacement-on-neurological-and-psychomotor-development-case-report
#2
Felipe Motta, Adriana Pasmanik Eisencraft, Lindiane Gomes Crisostomo
The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, cognition, and motor functions has been evaluated in experimental studies and in adults with central nervous system lesions. However, there is still little research on the clinical impact of hormone replacement on neurological and psychomotor development. This report presents the case of a patient with excellent weight-height recovery and, even more surprisingly, neurological and psychomotor development in response to use of growth hormone...
May 14, 2018: Einstein
https://www.readbyqxmd.com/read/29764099/assessment-of-treatment-field-isolation-during-scaling-root-planing-and-rinsing
#3
Michel Gigandet, Deborah Hofer, Thomas Attin, Philipp Sahrmann, Patrick R Schmidlin
Aim: Intensive application of highly concentrated antimicrobials during scaling and root planing may be hazardous if swallowed in quantity. This study evaluates two dental isolation systems for fluid leakage in conjunction with a sham treatment of scaling and root planing. Materials and methods: Eight volunteers were randomly assigned to wear a conventional rubber dam (RD) and a combined suction and isolation device (IsoLite® system [IL]) alternatively on contralateral maxillary and mandibular quadrants. RD was cut between the canine and the first molar and was fixed on the first molar with a rubber dam clamp and with a tissue adhesive (Histoacryl) on the gingiva...
May 16, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29747260/-current-status-and-prospect-of-photodynamic-therapy-in-laryngeal-diseases
#4
C Zhang, J Q Jiang
Laryngeal diseases are closely related to the swallowing and speech function of the patients.Protecting and restoring laryngeal function, while curing lesions, is vital to patients' quality of life.Photodynamic therapy (PDT) is a minimally invasive method which is widely used in the treatment of tumor, precancerous lesions, and inflammatory diseases.In recent years, it has been shown to have a protective effect on normal structures. This article reviews the clinical outcomes of laryngeal diseases treated with PDT since 1990 in order to evaluate its efficacy and significance...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29746402/update-in-therapeutic-strategies-for-parkinson-s-disease
#5
Jaime Kulisevsky, Lais Oliveira, Susan H Fox
PURPOSE OF REVIEW: To review recent advances in therapeutics for motor and nonmotor symptoms of Parkinson's disease. RECENT FINDINGS: Neuroprotection remains a large area of investigation with preliminary safety data on alpha synuclein immunotherapy and glucagon-like peptide-1 agonists. Novel Monoamine Oxidase B and Caetchol-O-methyltransferase-inhibitors for motor fluctuations have shown benefit and are recently approved for clinical use. Long-acting amantadine has also been approved to reduce dyskinesia...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#6
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29736758/socioeconomic-status-and-quality-of-life-in-patients-with-locally-advanced-head-and-neck-cancer
#7
S Tribius, M S Meyer, C Pflug, H Hanken, C-J Busch, A Krüll, C Petersen, C Bergelt
PURPOSE: Socioeconomic aspects play an important role in health care. Patients with locally advanced head and neck cancer (LAHNC) experience detrimental effects on their quality of life (QoL). This prospective study examines QoL differences between patients with different socioeconomic status (SES) after intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: In all, 161 patients were questioned at the end of IMRT and at 12 and 24 months follow-up using the questionnaires of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-30 and QLQ-HN35...
May 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29736223/the-effect-of-swallowing-rehabilitation-on-quality-of-life-of-the-dysphagic-patients-with-cortical-ischemic-stroke
#8
Kadir Bahcecı, Ebru Umay, Ibrahim Gundogdu, Eda Gurcay, Erhan Ozturk, Sibel Alıcura
Background: Swallowing and swallowing-related quality of life studies following stroke were almost always performed by including both patients with brainstem and cortical involvement. It was aimed in this study to show the presence of dysphagia in patients with only cortical ischemic stroke and to investigate the interaction between dysphagia and quality of life as well as to evaluate the effect of a rehabilitation program in the acute phase. Methods: Seventy-two patients with cortical stroke (between 0 and 30 days) and dysphagia were included...
October 7, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29731889/swallowing-disorder-following-salvage-total-pharyngo-laryngo-esophagectomy-with-free-jejunum-reconstruction
#9
Takashi Maruo, Minoru Sakuraba, Takeshi Shinozaki, Toshifumi Tomioka, Wataru Okano, Satoko Arahira, Yoshie Iino, Ryuichi Hayashi
For recurrent cases or residual cases following concomitant chemo-radiation therapy (CCRT), salvage surgery is a frequently used treatment options. A swallowing disorder is one of the major complications of CCRT. The purpose of the present study was to evaluate the effect of CCRT on swallowing function in patients who underwent salvage total pharyngo-laryngo-esophagectomy (TPLE), and to evaluate the importance of pharyngeal constriction in patients who underwent TPLE. Between 2008 January and 2014 May, 54 patients were treated with salvage TPLE following CCRT or TPLE at the National Cancer Center Hospital East, Chiba, Japan and were included in the present study...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29727486/reliability-and-validity-of-the-karaduman-chewing-performance-scale-in-pediatric-neuromuscular-diseases-a-system-for-classification-of-chewing-disorders
#10
Selen Serel Arslan, Güllü Aydın, İpek Alemdaroğlu, Öznur Tunca Yılmaz, Aynur Ayşe Karaduman
BACKGROUND: Chewing disorders can be seen in children with Neuromuscular Diseases (NMDs), which may cause swallowing difficulties like choking, retching, food stuck feeling in the throat. Due to these effects, it is important to determine chewing disorders early with appropriate assessment methods to plan appropriate therapies in NMDs. OBJECTIVE(S: The aim of this study was to investigate reliability and validity of the Karaduman Chewing Performance Scale (KCPS) in children with NMDs...
May 4, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29726748/efficacy-of-neuromuscular-electrical-stimulation-in-improving-the-negative-psychological-state-in-patients-with-cerebral-infarction-and-dysphagia
#11
Yanfang Zeng, James Yip, Hongli Cui, Longfei Guan, Haomeng Zhu, Weidong Zhang, Huishan Du, Xiaokun Geng
Objective To observe the improvement of negative affect disorders in patients with cerebral infarction and dysphagia by neuromuscular electrical stimulation. Methods One hundred and twelve patients with cerebral infarction and dysphagia were selected and randomized into treatment (n = 59) and control (n = 53) groups. Similar swallowing function was found in both groups before treatment: (1) Water-drinking test in the treatment group proved swallowing function Level III in 24 cases, Level IV in 22 cases and Level V in 13 cases; (2) in the control group, swallowing function was Level III in 21 cases, Level IV in 20 cases and Level V in 12 cases...
May 4, 2018: Neurological Research
https://www.readbyqxmd.com/read/29726363/dysphagia-treatment-for-patients-with-head-and-neck-cancer-undergoing-radiation-therapy-a-meta-analysis-review
#12
REVIEW
Elissa Greco, Tijana Simic, Jolie Ringash, George Tomlinson, Yoko Inamoto, Rosemary Martino
PURPOSE: Patients undergoing radiation therapy with or without chemotherapy (C/RT) for head and neck cancer (HNC) often develop dysphagia. Interventions from speech-language pathologists aim to maintain or improve swallow physiology and function. However, it is unclear which interventions provide the greatest benefit. We performed a systematic review to assess the benefit of exercise therapy on swallow physiology, function, and related quality of life (QOL). METHODS AND MATERIALS: We searched 7 electronic databases up to July 12, 2017, for all primary studies of any language or design that included the following: a behavioral swallowing intervention for patients with HNC treated with curative C/RT, a comparison group, and outcomes related to swallow physiology, function, and/or QOL...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29713896/pink1-rats-show-early-onset-swallowing-deficits-and-correlative-brainstem-pathology
#13
Kaylee P Cullen, Laura M Grant, Cynthia A Kelm-Nelson, Alexander F L Brauer, Luke B Bickelhaupt, John A Russell, Michelle R Ciucci
Parkinson disease (PD) compromises oropharyngeal swallowing, which negatively affects quality of life and contributes to aspiration pneumonia. Dysphagia often begins early in the disease process, and does not improve with standard therapies. As a result, swallowing deficits are undertreated in the PD population. The Pink1 -/- rat is used to model PD, and demonstrates widespread brainstem neuropathology in combination with early-onset sensorimotor dysfunction; however, to date, swallowing behaviors have not been evaluated...
April 30, 2018: Dysphagia
https://www.readbyqxmd.com/read/29713446/evidence-of-oropharyngeal-dysfunction-in-feeding-in-the-rat-rotenone-model-of-parkinson-s-disease
#14
François D H Gould, Andrew Gross, Rebecca Z German, Jason R Richardson
Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson's disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29710108/association-of-a-proactive-swallowing-rehabilitation-program-with-feeding-tube-placement-in-patients-treated-for-pharyngeal-cancer
#15
Gaurav S Ajmani, Cheryl C Nocon, Bruce E Brockstein, Nicholas P Campbell, Amy B Kelly, Jamie Allison, Mihir K Bhayani
Importance: A proactive speech and language pathology (SLP) program is an important component of the multidisciplinary care of patients with head and neck squamous cell carcinoma (HNSCC). Swallowing rehabilitation can reduce the rate of feeding tube placement, thereby significantly improving quality of life. Objective: To evaluate the initiation of a proactive SLP rehabilitation program at a single institution and its association with rates of feeding tube placement and dietary intake in patients with HNSCC...
April 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29710075/effect-of-perioperative-gabapentin-use-on-postsurgical-pain-in-patients-undergoing-head-and-neck-mucosal-surgery-a-randomized-clinical-trial
#16
Melanie Townsend, Tina Liou, Dorina Kallogjeri, Morgan Schoer, Nicholas Scott-Wittenborn, Miranda Lindburg, Michael Bottros, Ryan S Jackson, Brian Nussenbaum, Jay F Piccirillo
Importance: Effective postoperative pain management increases patient satisfaction, reduces cost, reduces morbidity, and shortens hospitalizations. Previous studies investigating multimodal pain therapy in otolaryngology patients focused on homogenous patient groups with short postoperative follow-up times. Objective: To investigate the effect of perioperative gabapentin treatment on postsurgical pain in patients undergoing head and neck mucosal surgery. Design, Setting, and Participants: Adults undergoing head and neck mucosal surgery from July 25, 2016, through June 19, 2017, were included in this double-blinded, placebo-controlled randomized clinical trial and randomized to receive gabapentin, 300 mg twice daily, or placebo before surgery and up to 72 hours after surgery...
April 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29708903/managing-the-late-effects-of-chemoradiation-on-swallowing-bolstering-the-beginning-minding-the-middle-and-cocreating-the-end
#17
Tessa Goldsmith, Marlene C Jacobson
PURPOSE OF REVIEW: Late dysphagia has a profound impact on quality of life in patients treated with chemoradiation therapy for advanced head and neck cancer and the number of survivors is growing. Traditional treatment methods are not uniformly successful in reducing the swallow impairment in these patients. RECENT FINDINGS: Manifestations of late dysphagia are complex and do not follow a uniform trajectory. Patient's experience of eating and engagement in treatment is critical given the complex, variable nature of late dysphagia...
June 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29703055/treatment-of-ramsay-hunt-s-syndrome-with-multiple-cranial-nerve-involvement-and-severe-dysphagia-a-case-report
#18
Jong Min Kim, Zeeihn Lee, Seungwoo Han, Donghwi Park
RATIONALE: Ramsay-Hunt's syndrome (RHS) is a disorder characterized by facial paralysis, herpetic eruptions on the auricle, and otic pain due to the reactivation of latent varicella zoster virus in the geniculate ganglion. A few cases of multiple cranial nerve invasion including the vestibulocochlear nerve, glossopharyngeal nerve and vagus nerve have been reported. However, there has been no report about RHS with delayed onset multiple cranial nerve involvement causing severe aspiration, and a clinical course that improved after more than one year of dysphagia rehabilitation and percutaneous endoscopic gastrostomy (PEG)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29703016/a-case-report-of-life-threatening-acute-dysphagia-in-dermatomyositis-challenges-in-diagnosis-and-treatment
#19
Kyoung Min Kwon, Jung Soo Lee, Yeo Hyung Kim
RATIONALE: Although dysphagia is a known complication of dermatomyositis, sudden onset of dysphagia without the notable aggravation of other symptoms can make the diagnosis and treatment challenging. PATIENT CONCERNS: A 53-year-old male diagnosed as dermatomyositis 1 month ago came to our emergency department complaining of a sudden inability to swallow solid foods and liquids. The patient showed generalized edema, but the muscle power was not different compared with 1 month ago...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696919/-therapeutic-effects-of-acupuncture-combined-with-rehabilitation-training-on-dysphagia-in-post-stroke-pseudobulbar-palsy
#20
Dan Chen, Haiying Guo
OBJECTIVE: To compare the therapeutic effects on dysphagia in post-stroke pseudobulbar palsy between the combined treatment with acupuncture and rehabilitation training and the combined treatment with low-frequency electrical therapy and rehabilitation training and to explore its more effective therapy, using the ultrasonographic examination. METHODS: A total of 60 patients of dysphagia in post-stroke pseudobulbar palsy were randomly assigned into an observation group and a control group, 30 cases in each one...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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