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Prabhjot Singh Nijjar, Fahad M Iqbal, M Chadi Alraies, Uma S Valeti, S Murthy Tadavarthy
No abstract text is available yet for this article.
May 7, 2016: European Heart Journal
Erik B Schelbert, Kayla M Piehler, Karolina M Zareba, James C Moon, Martin Ugander, Daniel R Messroghli, Uma S Valeti, Chung-Chou H Chang, Sanjeev G Shroff, Javier Diez, Christopher A Miller, Matthias Schmitt, Peter Kellman, Javed Butler, Mihai Gheorghiade, Timothy C Wong
BACKGROUND: Myocardial fibrosis (MF) in noninfarcted myocardium may be an interstitial disease pathway that confers vulnerability to hospitalization for heart failure, death, or both across the spectrum of heart failure and ejection fraction. Hospitalization for heart failure is an epidemic that is difficult to predict and prevent and requires potential therapeutic targets associated with outcomes. METHOD AND RESULTS: We quantified MF with cardiovascular magnetic resonance extracellular volume fraction (ECV) measures in 1172 consecutive patients without amyloidosis or hypertrophic or stress cardiomyopathy and assessed associations with outcomes using Cox regression...
December 2015: Journal of the American Heart Association
Prabhjot Singh Nijjar, Haree Vongooru, Ashenafi Tamene, Uma Valeti, Carolina Masri
No abstract text is available yet for this article.
July 2015: Minnesota Medicine
Forum Kamdar, Vijay Pera, Uma Valeti
Despite significant advances in the science of resuscitation, survival to discharge after an in-hospital cardiac arrest in the catheterization laboratory remains poor. Clinicians face the challenges of performing CPR during procedures to address the cause of the arrest and the limitations of prolonged manual CPR. In this article we describe the first case of a patient presenting in cardiogenic shock caused by acute coronary syndrome secondary to bypass graft failure who developed cardiac arrest and survived 80 minutes of resuscitation in the catheterization lab, allowing for revascularization of a vein graft...
May 2015: Minnesota Medicine
Prabhjot Singh Nijjar, Sofia Carolina Masri, Ashenafi Tamene, Helina Kassahun, Kenneth Liao, Uma Valeti
Primary cardiac tumors are far rarer than tumors metastatic to the heart. Angiosarcoma is the primary cardiac neoplasm most frequently detected; lymphomas constitute only 1% of primary cardiac tumors. We present the case of a 55-year-old woman with a recently diagnosed intracardiac mass who was referred to our institution for consideration of urgent orthotopic heart transplantation. Initial images suggested an angiosarcoma; however, a biopsy specimen of the mass was diagnostic for diffuse large B-cell lymphoma...
December 2014: Texas Heart Institute Journal
Kavitha M Chinnaiyan, Abhay N Bilolikar, Edward Walsh, Daniel Wood, Ann DePetris, Ralph Gentry, Judith Boura, Suhny Abbara, Mouaz Al-Mallah, Kostaki Bis, Gilbert Boswell, Michael Gallagher, Ing-Orn Arunakul, Sandra Halliburton, Jill Jacobs, John Lesser, U Joseph Schoepf, Uma S Valeti, Gilbert L Raff
OBJECTIVES: To establish current radiation dose levels with contemporary scanners capable of prospectively triggered or high-pitch spiral scan modes to previous generation scanners among patients evaluated for coronary artery disease, pulmonary embolism, aortic disease, and "triple rule out" in a large population of patients at multiple centers. BACKGROUND: Previous small-scale studies with carefully controlled scan protocols report that CT scanners that facilitate prospectively triggered scanning and provide high-pitch spiral CT scan modes drastically lower radiation doses...
May 2014: Journal of Cardiovascular Computed Tomography
Timothy C Wong, Kayla M Piehler, Karolina M Zareba, Kathie Lin, Ashley Phrampus, Agam Patel, James C Moon, Martin Ugander, Uma Valeti, Jonathan E Holtz, Bo Fu, Chung-Chou H Chang, Michael Mathier, Peter Kellman, Javed Butler, Mihai Gheorghiade, Erik B Schelbert
BACKGROUND: Hospitalization for heart failure (HHF) is among the most important problems confronting medicine. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) robustly identifies intrinsic myocardial damage. LGE may indicate inherent vulnerability to HHF, regardless of etiology, across the spectrum of heart failure stage or left ventricular ejection fraction (LVEF). METHODS AND RESULTS: We enrolled 1068 consecutive patients referred for CMR where 448 (42%) exhibited LGE...
2013: Journal of the American Heart Association
James A Goldstein, Kavitha M Chinnaiyan, Aiden Abidov, Stephan Achenbach, Daniel S Berman, Sean W Hayes, Udo Hoffmann, John R Lesser, Issam A Mikati, Brian J O'Neil, Leslee J Shaw, Michael Y H Shen, Uma S Valeti, Gilbert L Raff
OBJECTIVES: The purpose of this study was to compare the efficiency, cost, and safety of a diagnostic strategy employing early coronary computed tomographic angiography (CCTA) to a strategy employing rest-stress myocardial perfusion imaging (MPI) in the evaluation of acute low-risk chest pain. BACKGROUND: In the United States, >8 million patients require emergency department evaluation for acute chest pain annually at an estimated diagnostic cost of >$10 billion...
September 27, 2011: Journal of the American College of Cardiology
Szilard Voros, Juan J Rivera, Daniel S Berman, Ron Blankstein, Matthew J Budoff, Ricardo C Cury, Milind Y Desai, Damini Dey, Sandra S Halliburton, Harvey S Hecht, Khurram Nasir, Raul D Santos, Michael D Shapiro, Allen J Taylor, Uma S Valeti, Phillip M Young, Gaby Weissman
Coronary artery calcium (CAC) scanning is an important tool for risk stratification in intermediate-risk, asymptomatic subjects without previous coronary disease. However, the clinical benefit of improved risk prediction needs to be balanced against the risk of the use of ionizing radiation. Although there is increasing emphasis on the need to obtain CAC scans at low-radiation exposure to the patient, very few practical documents exist to aid laboratories and health care professionals on how to obtain such low-radiation scans...
March 2011: Journal of Cardiovascular Computed Tomography
Kenneth W Baran, Kathryn A Kamrowski, Jay J Westwater, Victor H Tschida, Charles F Alexander, Margaret M Beahrs, Thomas A Biggs, Patrick T Koller, Brian D Mahoney, Sara T Murray, Thomas E Raya, Peter K Rusterholz, Uma S Valeti, Thomas A Wiberg
No abstract text is available yet for this article.
July 2010: Circulation. Cardiovascular Quality and Outcomes
Manesh R Patel, Stephen G Worthley, Amanda Stebbins, Thorsten Dill, Frank E Rademakers, Uma S Valeti, Uma S Velleti, Gregory W Barsness, Frans Van de Werf, Christian W Hamm, Paul W Armstrong, Christopher B Granger, Raymond J Kim
OBJECTIVES: The purpose of the study was to understand determinants of infarct size in a primary percutaneous intervention (PCI) population treated with pexelizumab compared with placebo. BACKGROUND: In the multicenter APEX-AMI (Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction) trial, pexelizumab did not reduce 90-day mortality. Cardiac magnetic resonance (CMR) with delayed enhancement was used in a substudy evaluating infarct size and left ventricular ejection fraction (LVEF)...
January 2010: JACC. Cardiovascular Imaging
Ronen Rubinshtein, James F Glockner, Steve R Ommen, Philip A Araoz, Michael J Ackerman, Paul Sorajja, J Martijn Bos, A Jamil Tajik, Uma S Valeti, Rick A Nishimura, Bernard J Gersh
BACKGROUND: Myocardial late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) has been suggested to represent intramyocardial fibrosis and, as such, an adverse prognostic risk factor. We evaluated the characteristics of LGE on CE-MRI and explored whether LGE among patients with HCM was associated with genetic testing, severe symptoms, ventricular arrhythmias, or sudden cardiac death (SCD). METHODS AND RESULTS: Four hundred twenty-four patients with HCM (age=55+/-16 years [range 2 to 90], 41% females), without a history of septal ablation/myectomy, underwent CE-MRI (GE 1...
January 2010: Circulation. Heart Failure
Paul Sorajja, Uma Valeti, Rick A Nishimura, Steve R Ommen, Charanjit S Rihal, Bernard J Gersh, David O Hodge, Hartzell V Schaff, David R Holmes
BACKGROUND: The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. METHODS AND RESULTS: Among 601 patients with severely symptomatic obstructive hypertrophic cardiomyopathy referred for alcohol septal ablation or myectomy from 1998 to 2006, 138 patients (median age, 64 years; 39% men) chose to undergo ablation...
July 8, 2008: Circulation
Brian D Powell, Kevin A Bybee, Uma Valeti, Randal J Thomas, Stephen L Kopecky, Charles J Mullany, R Scott Wright
Statin therapy has recently been shown to decrease adverse perioperative events in patients undergoing vascular surgery. The potential beneficial effect of lipid-lowering therapy in patients undergoing coronary artery bypass grafting (CABG) is not well known. This was an observational analysis of 4,739 patients who underwent first-time isolated CABG at a single institution from 1995 to 2001. Patients were categorized into 2 groups based on treatment with a lipid-lowering agent within 30 days before surgery...
March 15, 2007: American Journal of Cardiology
Uma S Valeti, Rick A Nishimura, David R Holmes, Philip A Araoz, James F Glockner, Jerome F Breen, Steve R Ommen, Bernard J Gersh, A Jamil Tajik, Charanjit S Rihal, Hartzell V Schaff, Barry J Maron
OBJECTIVES: This study sought to describe the acute morphologic differences that result from septal myectomy and alcohol septal ablation using cardiac magnetic resonance (CMR) imaging. BACKGROUND: Surgical septal myectomy and alcohol septal ablation relieve left ventricular outflow tract obstruction in severely symptomatic patients with hypertrophic cardiomyopathy (HCM). METHODS: Cine and contrast-enhanced CMR images were obtained in HCM patients before and after septal myectomy (n = 24) and alcohol septal ablation (n = 24)...
January 23, 2007: Journal of the American College of Cardiology
F Rotellar, C Pastor, J Baixauli, A Gil, V Valetí, I Poveda, P Martí-Cruchaga
The spectacular increase in the prevalence of obesity in our society and the significant complications and comorbidities that it gives rise to have stimulated the interest of scientists and public in this pathology. Surgical treatment is at present the only efficient and lasting treatment for morbid obesity and in many cases it appreciably improves, and even definitively cures, associated complications such as the case of diabetes or hypertension. Amongst the different techniques of bariatric surgery, the gastric bypass (GBP) seems to be definitively establishing itself, since it offers an excellent balance between loss of weight (>70% of the excess), surgical risk and subsequent quality of life...
2005: Anales del Sistema Sanitario de Navarra
V Uma Valeti, Wookjin Chun, Donald D Potter, Philip A Araoz, Kiaran P McGee, James F Glockner, Timothy F Christian
PURPOSE: To determine whether imaging at 3 T could improve and prolong the tag contrast compared to images acquired at 1.5 T in normal volunteers, and whether such improvement would translate into the ability to perform strain measurements in diastole. MATERIALS AND METHODS: Normal volunteers (N = 13) were scanned at 1.5 T (GE Signa CV/i) and 3.0 T (GE VH/i). An ECG-triggered, segmented k-space, spoiled-gradient-echo grid-tagged sequence was used during cine acquisition...
April 2006: Journal of Magnetic Resonance Imaging: JMRI
David R Holmes, Uma S Valeti, Rick A Nishimura
Alcohol septal ablation for the treatment of hypertrophic cardiomyopathy has been the subject of great interest, and the number of procedures performed is increasing despite an absence of randomized trial data. Although straightforward in concept, alcohol septal ablation may be considerably more difficult in actual practice. To optimize the results and prevent complications, the anatomy of the septal arcade architecture must be understood and the anatomic relationship between the septal artery and the specific portion of the septum to be ablated must be carefully delineated...
November 2005: Catheterization and Cardiovascular Interventions
Kevin A Bybee, Brian D Powell, Uma Valeti, A Gabriela Rosales, Stephen L Kopecky, Charles Mullany, R Scott Wright
BACKGROUND: Aspirin is beneficial in the setting of atherosclerotic cardiovascular disease. There are limited data evaluating preoperative aspirin administration preceding coronary artery bypass grafting and associated postoperative outcomes. METHODS AND RESULTS: Using prospectively collected data from 1636 consecutive patients undergoing first-time isolated coronary artery bypass surgery at our institution from January 2000 through December 2002, we evaluated the association between aspirin usage within the 5 days preceding coronary bypass surgery and risk of adverse in-hospital postoperative events...
August 30, 2005: Circulation
James A Fallavollita, Brian J Riegel, Gen Suzuki, Uma Valeti, John M Canty
Pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy are at high risk of sudden cardiac death (SCD). We sought to identify the arrhythmic mechanism of SCD, the relation to changes in left ventricular (LV) function, and inducibility of malignant arrhythmias before SCD. Juvenile pigs (n = 72) were instrumented with chronic stenoses on proximal left anterior descending and circumflex arteries. Survival was only 29% 3 mo after instrumentation, and all deaths were sudden and without prodromal symptoms of heart failure...
December 2005: American Journal of Physiology. Heart and Circulatory Physiology
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