keyword
MENU ▼
Read by QxMD icon Read
search

Speciosa

keyword
https://www.readbyqxmd.com/read/29151994/antimicrobial-activity-of-cultivable-endophytic-fungi-associated-with-hancornia-speciosa-gomes-bark
#1
Mardonny Bruno de Oliveira Chagas, Irailton Prazeres Dos Santos, Luis Claudio Nascimento da Silva, Maria Tereza Dos Santos Correia, Janete Magali de Araújo, Marilene da Silva Cavalcanti, Vera Lucia de Menezes Lima
Introduction: In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with Hancornia speciosa Gomes stem bark. Methods and Materials: Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In total, 116 endophytic fungi strains were isolated from 90 fragments (64.4% frequency of colonization). Higher fungi frequency was observed in the rainy season (84.4%). The strains were grouped into 14 species; the most frequent were Phoma cava (13...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29076424/physicochemical-characterization-of-mitragyna-speciosa-alkaloid-extract-and-mitragynine-using-in-vitro-high-throughput-assays
#2
Wai Mun Kong, Zamri Chik, Zahurin Mohamed, Mohammed A Alshawsh
Mitragynine, a major active alkaloid of Mitragyna speciosa, acts as an agonist on μ-opioid receptors, producing effects similar to morphine and other opioids. It has been traditionally utilized to alleviate opiate withdrawal symptoms. Besides consideration about potency and selectivity, a good drug must possess a suitable pharmacokinetic profile, with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile, in order to have a high chance of success in clinical trials. The purity of mitragynine in a Mitragyna speciosa alkaloid extract (MSAE) was determined using Ultra-Fast Liquid Chromatography (UFLC)...
October 26, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29071751/pxr-mediated-induction-of-cyp3a4-cyp1a2-and-p-gp-by-mitragyna-speciosa-and-its-alkaloids
#3
Vamshi K Manda, Bharathi Avula, Olivia R Dale, Zulfiqar Ali, Ikhlas A Khan, Larry A Walker, Shabana I Khan
Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly. A few reports are available related to the effects of kratom on the activity of cytochrome P450 enzymes (CYPs), but there are no reports of its effects on pregnane X receptor (PXR), a transcription factor that regulates the expression of CYPs and P-glycoprotein (P-gp)...
October 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29043045/radseq-dataset-with-90-missing-data-fully-resolves-recent-radiation-of-petalidium-acanthaceae-in-the-ultra-arid-deserts-of-namibia
#4
Erin A Tripp, Yi-Hsin Erica Tsai, Yongbin Zhuang, Kyle G Dexter
Deserts, even those at tropical latitudes, often have strikingly low levels of plant diversity, particularly within genera. One remarkable exception to this pattern is the genus Petalidium (Acanthaceae), in which 37 of 40 named species occupy one of the driest environments on Earth, the Namib Desert of Namibia and neighboring Angola. To contribute to understanding this enigmatic diversity, we generated RADseq data for 47 accessions of Petalidium representing 22 species. We explored the impacts of 18 different combinations of assembly parameters in de novo assembly of the data across nine levels of missing data plus a best practice assembly using a reference Acanthaceae genome for a total of 171 sequence datasets assembled...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29039766/identification-and-characterization-of-tale-homeobox-genes-in-the-endangered-fern-vandenboschia-speciosa
#5
Mercedes Ruiz-Estévez, Mohammed Bakkali, Rubén Martín-Blázquez, Manuel A Garrido-Ramos
We report and discuss the results of a quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis of the expression patterns of seven three amino acid loop extension (TALE) homeobox genes (four KNOTTED-like homeobox (KNOX) and three BEL1-like homeobox (BELL) genes) identified after next generation sequencing (NGS) and assembly of the sporophyte and gametophyte transcriptomes of the endangered fern species Vandenboschia speciosa. Among the four KNOX genes, two belonged to the KNOX1 class and the other two belonged to the KNOX2 class...
October 17, 2017: Genes
https://www.readbyqxmd.com/read/28992471/parkia-speciosa-empty-pod-prevents-hypertension-and-cardiac-damage-in-rats-given-n-g-nitro-l-arginine-methyl-ester
#6
Yusof Kamisah, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Kamsiah Jaarin
Parkia speciosa Hassk is a plant found abundantly in Southeast Asia region. Its seeds with or without pods and roots have been used in traditional medicine in this region to treat hypertension. Therefore, we aimed to investigate the potential effect of the plant empty pod extract on hypertension development and changes in heart induced by N(G)-nitro-l-arginine methyl ester (l-NAME) administration in rats. Twenty-four male Sprague Dawley rats were divided into four groups. Groups 1 to 3 were given l-NAME (25mg/kg, intraperitoneally) for 8 weeks...
October 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28966251/enhancement-of-endothelial-barrier-permeability-by-mitragynine
#7
Toshiyuki Matsunaga, Yoshifumi Morikawa, Kyoko Kamase, Misato Horinouchi, Yasuhide Sasajima, Koichi Suenami, Kiyohito Sato, Yuji Takekoshi, Satoshi Endo, Ossama El-Kabbani, Akira Ikari
Persistent inhalation of mitragynine (MG), a major alkaloid in the leaves of Mitragyna speciosa, causes various systemic adverse effects such as seizure, diarrhea and arthralgias, but its toxicity to endothelial cells and effects on barrier function of the cells are poorly understood. In this study, we compared toxicities of MG and mitraphylline, another constituent of the leaves, against human aortic endothelial (HAE), bronchial BEAS-2B, neuronal SK-N-SH, hepatic HepG2, kidney HEK293, gastric MKN45, colon DLD1, lung A549, breast MCF7 and prostate LNCaP cells, and found that MG, but not mitraphylline, shows higher toxicity to HAE cells compared to the other cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28961914/milkweed-matters-monarch-butterfly-lepidoptera-nymphalidae-survival-and-development-on-nine-midwestern-milkweed-species
#8
COMPARATIVE STUDY
V M Pocius, D M Debinski, J M Pleasants, K G Bidne, R L Hellmich, L P Brower
The population of monarch butterflies east of the Rocky Mountains has experienced a significant decline over the past 20 yr. In order to increase monarch numbers in the breeding range, habitat restoration that includes planting milkweed plants is essential. Milkweeds in the genus Asclepias and Cynanchum are the only host plants for larval monarch butterflies in North America, but larval performance and survival across nine milkweeds native to the Midwest is not well documented. We examined development and survival of monarchs from first-instar larval stages to adulthood on nine milkweed species native to Iowa...
October 1, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28950813/a-review-on-the-antinociceptive-effects-of-mitragyna-speciosa-and-its-derivatives-in-animal-model
#9
Kok-Yong Chin, Wun Fui Mark-Lee
Mitragyna speciosa is a tropical plant with narcotic effects. The antinociceptive effects of its crude extracts, bioactive compounds and structurally modified derivatives have been examined in rodent models. This review aims to summarize the evidence on the antinociceptive effects of M. speciosa and its derivatives and explore whether they can offer an alternative to morphine in pain management. Methanolic and alkaloid extracts of M. speciosa were shown to attenuate the nociceptive response in rodents. Mitragynine and 7-hydroxymitragynine offered better antinociceptive effects than crude extracts...
September 25, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28947930/mitragyna-speciosa-balancing-potential-medical-benefits-and-abuse
#10
EDITORIAL
Genevieve M Halpenny
Mitragyna speciosa, also known as kratom, has the potential meet the need for pain medications that lack the addictiveness and overdose risk of classical opioid analgesics, such as morphine. This need is urgent because opioid addiction and overdose deaths have risen throughout diverse segments of U.S. society. Some opioid addicts have found relief in kratom preparations. The use of kratom as an analgesic has been validated by historical accounts and contemporary pharmacological research. Although kratom is a promising source of analgesic candidates, it is a euphoriant with potential for both abuse and addiction...
September 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28928515/effect-of-boiling-and-drying-process-on-chemical-composition-and-antioxidant-activity-of-chaenomeles-speciosa
#11
Jing Miao, Kunhua Wei, Xia Li, Chengcheng Zhao, Xuetao Chen, Xinhui Mao, Hanhan Huang, Wenyuan Gao
Chemical composition and antioxidant activity of fresh and boiled Chaenomeles speciosa (CS) slices dried by different drying methods were determined. Data were analyzed by principle component analysis and cluster analysis. All dried boiled CS from dried fresh CS slices form main cluster. The results also demonstrated that both drying methods, freeze drying and hot air drying at 60 °C had good potential in the industrial drying of fresh and boiled CS. Fresh CS dried by hot air drying at 60 °C was more suitable for the industrial production...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28830758/the-medicinal-chemistry-and-neuropharmacology-of-kratom-a-preliminary-discussion-of-a-promising-medicinal-plant-and-analysis-of-its-potential-for-abuse
#12
REVIEW
Andrew C Kruegel, Oliver Grundmann
The leaves of Mitragyna speciosa (commonly known as kratom), a tree endogenous to parts of Southeast Asia, have been used traditionally for their stimulant, mood-elevating, and analgesic effects and have recently attracted significant attention due to increased use in Western cultures as an alternative medicine. The plant's active alkaloid constituents, mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as partial agonists at mu-opioid receptors and competitive antagonists at kappa- and delta-opioid receptors...
August 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28796437/a-selective-insecticidal-protein-from-pseudomonas-mosselii-for-corn-rootworm-control
#13
Jun-Zhi Wei, Jessica O'Rear, Ute Schellenberger, Barbara A Rosen, Young-Jun Park, Mark J McDonald, Genhai Zhu, Weiping Xie, Adane Kassa, Lisa Procyk, Claudia Perez Ortega, Jian-Zhou Zhao, Nasser Yalpani, Virginia C Crane, Scott H Diehn, Gary A Sandahl, Mark E Nelson, Albert L Lu, Gusui Wu, Lu Liu
The coleopteran insect western corn rootworm (WCR, Diabrotica virgifera virgifera) is an economically important pest in North America and Europe. Transgenic corn plants producing Bacillus thuringiensis (Bt) insecticidal proteins have been useful against this devastating pest, but evolution of resistance has reduced their efficacy. Here, we report the discovery of a novel insecticidal protein, PIP-47Aa, from an isolate of Pseudomonas mosselii. PIP-47Aa sequence shows no shared motifs, domains or signatures with other known proteins...
August 10, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28687506/effects-of-alkaloid-rich-extract-from-mitragyna-speciosa-korth-havil-on-naloxone-precipitated-morphine-withdrawal-symptoms-and-local-field-potential-in-the-nucleus-accumbens-of-mice
#14
Dania Cheaha, Chayaporn Reakkamnuan, Jakkrit Nukitram, Somsmorn Chittrakarn, Pimpimol Phukpattaranont, Niwat Keawpradub, Ekkasit Kumarnsit
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa (Korth.) Havil. (M. speciosa) is among the most well-known plants used in ethnic practice of Southeast Asia. It has gained increasing attention as a plant with potential to substitute morphine in addiction treatment program. However, its action on the central nervous system is controversial. AIM OF THE STUDY: This study investigated the effects of M. speciosa alkaloid extract on naloxone-precipitated morphine withdrawal and neural signaling in the nucleus accumbens (NAc, brain reward center) of mice...
July 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28611818/long-term-effects-of-red-and-blue-light-emitting-diodes-on-leaf-anatomy-and-photosynthetic-efficiency-of-three-ornamental-pot-plants
#15
Liang Zheng, Marie-Christine Van Labeke
Light quality critically affects plant development and growth. Development of light-emitting diodes (LEDs) enables the use of narrow band red and/or blue wavelengths as supplementary lighting in ornamental production. Yet, long periods under these wavelengths will affect leaf morphology and physiology. Leaf anatomy, stomatal traits, and stomatal conductance, leaf hydraulic conductance (Kleaf), and photosynthetic efficiency were investigated in three ornamental pot plants, namely Cordyline australis (monocot), Ficus benjamina (dicot, evergreen leaves), and Sinningia speciosa (dicot, deciduous leaves) after 8 weeks under LED light...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28588492/cytotoxic-and-enzyme-inhibitory-potential-of-two-potentilla-species-p-speciosa-l-and-p-reptans-willd-and-their-chemical-composition
#16
Sengul Uysal, Gokhan Zengin, Marcello Locatelli, Mir B Bahadori, Andrei Mocan, Giuseppe Bellagamba, Elisa De Luca, Adriano Mollica, Abdurrahman Aktumsek
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28559179/opioid-receptors-mediate-the-acquisition-but-not-the-expression-of-mitragynine-induced-conditioned-place-preference-in-rats
#17
Nurul H M Yusoff, Sharif M Mansor, Christian P Müller, Zurina Hassan
Mitragynine is the main psychoactive ingredient of the herbal drug preparation Kratom (Ketum), derived from the plant Mitragyna speciosa. Kratom is a widely abused drug in Southeast Asian and has a psychostimulant profile at low-medium doses, while high doses have opioidergic effects. Mitragynine was shown to possess opiate receptor affinity. However, its role in the behavioural effects of mitragynine is unclear. Here we asked whether the reinforcing effects of mitragynine are mediated by opiate receptors using a conditioned place preference (CPP) paradigm in rats...
August 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28551311/evaluation-of-pharmacokinetics-and-blood-brain-barrier-permeability-of-mitragynine-using-in-vivo-microdialysis-technique
#18
Wai Mun Kong, Zahurin Mohamed, Mohammed A Alshawsh, Zamri Chik
A microdialysis system coupled with a sensitive ultra-fast liquid chromatography-mass spectrometry (UFLC-MS) method was developed for the pharmacokinetic analysis of mitragynine in rat blood and striatum. Mitragynine is an active alkaloid of Mitragyna speciosa and has been proposed to be used for opioid withdrawal therapy. In this study, chromatographic separation was performed in a gradient elution mode with 0.1% formic acid and acetonitrile on a Zorbax Eclipse C18 column. The mass spectrometric (MS) analysis was carried out in a positive electrospray mode and mitragynine ion (m/z 399...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28544011/changing-trends-in-the-use-of-kratom-mitragyna-speciosa-in-southeast-asia
#19
Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Ornella Corazza, Rita Santacroce, Andres Roman-Urrestarazu
OBJECTIVE: Kratom (Mitragyna speciosa. Korth) is an indigenous medicinal plant of Southeast Asia. This review paper aims to describe the trends of kratom use in Southeast Asia. DESIGN: A literature review search was conducted through ScienceDirect, Scopus, ProMed and Google Scholar. Twenty-five articles illustrating kratom use in humans in Southeast Asia were reviewed. RESULTS: Kratom has long been used by rural populations in Southeast Asia as a remedy for common ailments, to fight fatigue from hard manual work, as a drink during social interaction among men, and in village religious functions...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28537012/nutraceutical-effects-on-glucose-and-lipid-metabolism-in-patients-with-impaired-fasting-glucose-a-pilot-double-blind-placebo-controlled-randomized-clinical-trial-on-a-combined-product
#20
Arrigo Francesco Giuseppe Cicero, Federica Fogacci, Martino Morbini, Alessandro Colletti, Marilisa Bove, Maddalena Veronesi, Marina Giovannini, Claudio Borghi
INTRODUCTION: A number of natural compounds have individually demonstrated to improve glucose and lipid levels in humans. AIM: To  evaluate the short-term glucose and lipid-lowering activity in subjects with impaired fasting glucose. METHODS: To assess the effects of a combination of nutraceuticals based on Lagerstroemia speciosa, Berberis aristata, Curcuma longa, Alpha-lipoic acid, Chrome picolinate and Folic acid, we performed a double-blind, parallel group, placebo-controlled, randomized clinical trial in 40 adults affected by impaired fasting glucose (FPG = 100-125 mg/dL) in primary prevention of cardiovascular disease...
May 23, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
keyword
keyword
27527
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"