keyword
https://read.qxmd.com/read/38528484/umbilical-cord-blood-cell-characteristics-in-very-preterm-neonates-for-autologous-cell-therapy-of-preterm-associated-complications
#1
JOURNAL ARTICLE
Ren Zhuxiao, Han Jiangxue, Li Yongsheng, Pei Jingjun, Yang Shuo, Xu Fang, Zhang Qi, Zhang Shandan, Nie Chuan, Yang Jie
BACKGROUND: There are emerging clinical evidence for umbilical cord blood mononuclear cells (UCBMNCs) intervention to improve preterm complications. The first critical step in cell therapy is to obtain high-quality cells. This retrospective study aimed to investigate the quantity and quality of UCBMNCs from very preterm infants (VPIs) for the purpose of autologous cell therapy in prevention and treatment of preterm complications. METHODS: Very preterm infants (VPIs) born in Guangdong Women and Children Hospital from January 1, 2017, to December 8, 2022, from whom cord blood was successfully collected and separated for public or private banking, were enrolled...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38527841/-single-non-blood-related-umbilical-cord-blood-transplantation-using-a-reduced-intensity-conditioning-regimen-for-the-treatment-of-severe-aplastic-anemia
#2
JOURNAL ARTICLE
Y Wu, B L Tang, K D Song, G Y Sun, T Z Pan, A J Huang, B B Yan, X Y Zhu
Objective: To evaluated the clinical efficacy of a reduced-intensity preconditioning regimen for single non-blood-related umbilical cord blood transplantation (sUCBT) in the treatment of severe aplastic anemia (SAA) . Methods: The clinical data of 63 patients with SAA who underwent sUCBT from January 2021 to July 2023 at the Department of Hematology of the First Affiliated Hospital of USTC were retrospectively analyzed. Fifty-two patients received total body irradiation/total bone marrow irradiation (TMI) combined with fludarabine or a cyclophosphamide- conditioning regimen (non-rATG group) , while 11 patients received rabbit anti-human thymocyte immunoglobulin (rATG) combined with TMI, fludarabine, or the cyclophosphamide-conditioning regimen (rATG group) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38523199/sustained-remission-after-cord-blood-transplantation-for-breast-cancer-with-lung-metastases-and-myelodysplastic-syndrome
#3
JOURNAL ARTICLE
Naokazu Nakamura, Nao Yamamoto, Tadakazu Kondo, Mayumi Matsumoto, Ryo Ikunari, Tomomi Sakai, Yasuhiro Tanaka, Hiroko Tsunemine, June Takeda, Junya Kanda, Yasuhito Nannya, Seishi Ogawa, Akifumi Takaori-Kondo, Nobuyoshi Arima
Allogenic hematopoietic stem cell transplantation (allo-HSCT) is not a standard therapy for solid cancer because of its high toxicity and insufficient evidence levels. However, the potential graft-versus-solid-tumor (GVT) effect of this therapy has been discussed. Many case reports have also described treatment effects of allo-HSCT in patients with hematologic malignancies and active solid tumors. A 38-year-old woman treated with fulvestrant and abemaciclib for recurrent breast cancer with multiple lung metastases was diagnosed with myelodysplastic syndrome (MDS) with increased blasts 2...
March 25, 2024: International Journal of Hematology
https://read.qxmd.com/read/38521608/impact-of-fda-s-hct-p-zikv-recommendations-on-cord-blood-unit-eligibility-and-utilization-in-a-large-public-cord-blood-bank
#4
JOURNAL ARTICLE
Dana S Guggenheim, Joanne Kurtzberg, Beth H Shaz
BACKGROUND: Cord blood units (CBUs) that are ineligible for licensure due to incomplete compliance with FDA recommendations may be used for hematopoietic stem cell transplantation under urgent medical need and an Investigational Drug Application. The largest reason for CBU donor ineligibility is Zika virus (ZIKV) risk. The study's objective was to analyze the impact of current FDA recommendations for ZIKA risk on a large public cord blood bank and propose updated recommendations. METHODS: We performed a retrospective analysis of Carolinas Cord Blood Bank (CCBB), an FDA licensed public CBB, using data from January 1, 2016 to November 21, 2023 and compared FDA recommendations for transfusion transmitted infections (TTI) for blood products and relevant communicable disease agents or diseases for human cell, tissue, or cellular or tissue-based products (HCT/Ps)...
March 23, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38519559/x-irradiated-umbilical-cord-blood-cells-retain-their-regenerative-effect-in-experimental-stroke
#5
JOURNAL ARTICLE
Kazuta Yasui, Yuko Ogawa, Orie Saino, Rie Akamatsu, Akihiro Fuchizaki, Yoriko Irie, Makoto Nabetani, Mitsunobu Tanaka, Yoshihiro Takihara, Akihiko Taguchi, Takafumi Kimura
Although regenerative therapy with stem cells is believed to be affected by their proliferation and differentiation potential, there is insufficient evidence regarding the molecular and cellular mechanisms underlying this regenerative effect. We recently found that gap junction-mediated cell-cell transfer of small metabolites occurred very rapidly after stem cell treatment in a mouse model of experimental stroke. This study aimed to investigate whether the tissue repair ability of umbilical cord blood cells is affected by X-irradiation at 15 Gy or more, which suppresses their proliferative ability...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38511389/impact-of-donor-nkg2d-and-mica-gene-polymorphism-on-clinical-outcomes-of-adult-and-paediatric-allogeneic-cord-blood-transplantation-for-malignant-diseases
#6
JOURNAL ARTICLE
Steven T Cox, Warren Patterson, Richard Duggleby, Owen J R Jones, J Alejandro Madrigal, Sergi Querol, Francesc Rudilla Salvador, Maria Jose Herrero Mata, Fernanda Volt, Éliane Gluckman, Richard Szydlo, Robert D Danby, Diana Hernandez
OBJECTIVES: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated correlation between cord blood (CB) NKG2D and MICA genotypes and haematopoietic stem cell (HSC) transplant outcome...
March 21, 2024: European Journal of Haematology
https://read.qxmd.com/read/38509833/targeted-repair-of-spinal-cord-injury-based-on-mirna-124-3p-loaded-mesoporous-silica-camouflaged-by-stem-cell-membrane-modified-with-rabies-virus-glycoprotein
#7
JOURNAL ARTICLE
Xiangchuang Fan, Lusen Shi, Zimeng Yang, Yiwei Li, Chi Zhang, Baoshuai Bai, Lu Chen, Elzat Elham-Yilizati Yilihamu, Zhangyang Qi, Wenxiang Li, Peng Xiao, Mingshan Liu, Jichuan Qiu, Fan Yang, Ning Ran, Yifan Shang, Jiaxing Liu, Tehan Zhang, Xiaohong Kong, Hong Liu, Hengxing Zhou, Shiqing Feng
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG)...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38499435/decoding-human-in-vitro-terminal-erythropoiesis-originating-from-umbilical-cord-blood-mononuclear-cells-and-pluripotent-stem-cells
#8
JOURNAL ARTICLE
Xiaoling Wang, Wei Zhang, Siqi Zhao, Hao Yan, Zijuan Xin, Tiantian Cui, Ruge Zang, Lingping Zhao, Haiyang Wang, Junnian Zhou, Xuan Li, Wen Yue, Jiafei Xi, Zhaojun Zhang, Xiangdong Fang, Xuetao Pei
Ex vivo red blood cell (RBC) production generates unsatisfactory erythroid cells. A deep exploration into terminally differentiated cells is required to understand the impairments for RBC generation and the underlying mechanisms. Here, we mapped an atlas of terminally differentiated cells from umbilical cord blood mononuclear cells (UCBMN) and pluripotent stem cells (PSC) and observed their dynamic regulation of erythropoiesis at single-cell resolution. Interestingly, we detected a few progenitor cells and non-erythroid cells from both origins...
March 18, 2024: Cell Proliferation
https://read.qxmd.com/read/38496190/atypical-peripheral-retinal-necrosis-without-ocular-inflammation-and-retinal-whitening-in-a-patient-with-acute-myelogenous-leukemia-a-case-report
#9
Yoshihiro Nakagawa, Xue Tan, Hikari Yoshida, Takahiro Suzuki, Yasuyuki Suzuki
Retinal necrosis is a severe condition that threatens visual function. It is caused by viruses that are known to cause acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), which are called necrotizing herpetic retinopathies (NHR). ARN causes severe intraocular inflammation, including anterior chamber intravitreal cells, keratic precipitate, vitreous opacity, and retinal vasculitis, whereas intraocular inflammation in PORN is considered mild or virtually absent. In addition, PORN is a disease that manifests in immunosuppressive patients, such as those with acquired immunodeficiency syndrome...
February 2024: Curēus
https://read.qxmd.com/read/38490657/human-umbilical-cord-mesenchymal-stem-cell-therapy-for-renal-dysfunction-in-alport-syndrome-protocol-for-an-open-label-single-arm-trial-in-china
#10
JOURNAL ARTICLE
Li Huang, Jun Zou, Yuxin Zhang, Jiaowei Gu, Jianlong Wu, Che Zhang
INTRODUCTION: Alport syndrome (AS) is one of the most common fatal hereditary renal diseases in human, with a high risk of progressing to end-stage renal disease without effective treatments. Mesenchymal stem cells (MSCs) have recently emerged as a promising therapeutic strategy for chronic kidney disease. However, the safety and therapeutic potential of MSC transfusion for patients with AS are still need to be confirmed. Therefore, we have designed a clinical trial to evaluate the hypothesis that intravenous infusion of human umbilical cord-derived MSC (hUC-MSC) is safe, feasible, and well-tolerated in children with AS...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38486352/klotho-in-pregnancy-and-intrauterine-development-potential-clinical-implications-a-review-from-the-european-renal-association-ckd-mbd-working-group
#11
JOURNAL ARTICLE
Mehmet Kanbay, Ali Mutlu, Cicek N Bakir, Ibrahim B Peltek, Ata A Canbaz, Juan Miguel Díaz Tocados, Mathias Haarhaus
Intrauterine development is crucial for life-long health; therefore, elucidation of its key regulators is of interest for their potential prognostic and therapeutic implications. Originally described as a membrane-bound anti-aging protein, Klotho has evolved as a regulator of numerous functions in different organ systems. Circulating Klotho is generated by alternative splicing or active shedding from cell membranes. Recently, Klotho was identified as a regulator of placental function, and while Klotho does not cross the placental barrier, increased levels of circulating α-Klotho have been identified in umbilical cord blood compared to maternal blood, indicating that Klotho may also play a role in intrauterine development...
March 14, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38485627/-update-for-cord-blood-unit-selection-in-hematopoietic-stem-cell-transplantation-workshop-sfgm-tc
#12
Valérie Dubois, Lucie Blandin, Marion Duclaut, Alix Duquesne, Lionel Faivre, Romain Ferru-Clement, Jean Roy, Alexandre Walencik, Leonardo Magro, Federico Garnier
Changing practices and the limited use of cord blood units as a source of cells for allogeneic hematopoietic stem cell transplants (HSC) led us to reconsider the recommendations established in 2011 and 2012, and to propose an update incorporating recent bibliographic data. If HLA compatibility was until now established at low resolution for HLA-A and B loci, and at high resolution for HLA-DRB1, the recent papers are converging towards an increase in the level of resolution, making way for a compatibility now defined in high resolution for all the considered loci, and the inclusion of the HLA-C locus, in order to establish a level of HLA compatibility on 8 alleles (HLA-A, B, C and DRB1)...
March 13, 2024: Bulletin du Cancer
https://read.qxmd.com/read/38481366/the-impact-of-omidubicel-on-immune-reconstitution-and-infections-in-cord-blood-transplant-patients
#13
JOURNAL ARTICLE
Hong De Sa, Richard T Maziarz, Arpita P Gandhi
INTRODUCTION: The success of an allogeneic hematopoietic stem cell transplantation (alloHCT) is measured by cure from the underlying malignancy, immune reconstitution (IR), and freedom from graft-versus-host disease, without the continued need for immunosuppressive therapy. AREAS COVERED: Effective IR is critical to the success of alloHCT wherein poor IR can potentially increase the risk of infection and disease relapse. Different stem cell sources give rise to varying patterns of IR...
March 14, 2024: Expert Opinion on Biological Therapy
https://read.qxmd.com/read/38480861/therapeutic-effect-and-study-of-human-umbilical-cord-blood-mononuclear-cells-in-patients-with-ischaemic-bowel-disease
#14
JOURNAL ARTICLE
Xiaoxiao Cai, Yonghao Li, Fengyu Gao, Bilal Muhammad, Hongli Yang
Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38467271/boundary-cap-neural-crest-stem-cells-promote-angiogenesis-after-transplantation-to-avulsed-dorsal-roots-in-mice-and-induce-migration-of-endothelial-cells-in-3d-printed-scaffolds
#15
JOURNAL ARTICLE
Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need. Previous research has shown that sensory axons from peripherally grafted human sensory neurons are able to enter the spinal cord by growing along BVs which penetrate the CNS from the spinal cord surface...
March 9, 2024: Neuroscience Letters
https://read.qxmd.com/read/38458476/gut-immunomodulation-with-vedolizumab-prior-to-allogeneic-hematopoietic-stem-cell-transplantation-in-pediatric-patients-with-inflammatory-bowel-disease
#16
JOURNAL ARTICLE
Yogi Chopra, Karol Acevedo, Aleixo Muise, Karen Frost, Tal Schechter, Joerg Krueger, Muhammad Ali, Kuang-Yueh Chiang, V Y Kim, Eyal Grunebaum, Donna Wall
BACKGROUND: Inborn errors of immunity (IEI) are often associated with inflammatory bowel disease (IBD). IEI can be corrected by allogeneic hematopoietic stem cell transplantation (HSCT) however peri-transplantation intestinal inflammation may lead to increased risk of gut graft-versus-host disease (GVHD). Vedolizumab inhibits the homing of lymphocytes to the intestine and may attenuate gut GVHD, yet its role in preventing GvHD in pediatric patients with IEI-associated IBD has not been studied...
March 6, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38455103/effects-of-different-concentrations-of-nicotinamide-on-hematopoietic-stem-cells-cultured-in-vitro
#17
JOURNAL ARTICLE
Yan Ren, Yan-Ni Cui, Hong-Wei Wang
BACKGROUND: In vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo , but its effect on hematopoietic stem and progenitor cells (HSPCs, CD34+ CD38) and functional subtypes of HSCs - short-term repopulating HSCs (ST-HSCs, CD34+ CD38CD45RACD49f+ ) and long-term repopulating HSCs (LT-HSCs, CD34+ CD38CD45RACD49f+ CD90+ ) is not yet known. As a sirtuin 1 (SIRT1) inhibitor, NAM participates in regulating cell adhesion, polarity, migration, proliferation, and differentiation...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38452872/umbilical-cord-blood-transplantation-for-fanconi-anemia-with-a-special-focus-on-late-complications-a-study-on-behalf-of-eurocord-and-saawp-ebmt
#18
JOURNAL ARTICLE
Hanadi Rafii, Fernanda Volt, Marc Bierings, Jean-Hugues Dalle, Mouhab Ayas, Rawad Rihani, Maura Faraci, Giuseppina de Simone, Henrik Sengeloev, Jakob Passweg, Marina Cavazzana, Regis Costello, Johan Maertens, Alessandra Biffi, Jan-Erik Johansson, Juan Montoro, Gabrielle Roth Guepin, Miguel Angel Diaz, Anne Sirvent, Chantal Kenzey, Monica M Rivera Franco, Barbara Cappelli, Graziana Maria Scigliuolo, Vanderson Rocha, Annalisa Ruggeri, Antonio Risitano, Regis Peffault De Latour, Eliane Gluckman
BACKGROUND: Hematopoietic cell transplant (HCT) remains the only available curative treatment for Fanconi Anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) transplant. OBJECTIVES: To describe outcomes, with a special focus on late complications, in FA patients who underwent umbilical cord blood transplantation (UCBT). STUDY DESIGN: Retrospective analysis of allogeneic UCBT for FA performed between 1988 and 2021 in European Society for Blood and Marrow Transplantation (EBMT) affiliated centers...
March 5, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38447268/in-vivo-and-in-vitro-effects-of-cord-blood-hematopoietic-stem-and-progenitor-cell-hspc-expansion-using-valproic-acid-and-or-nicotinamide
#19
JOURNAL ARTICLE
Emine Begum Gencer, Hasan Yalim Akin, Selami Kocak Toprak, Eylul Turasan, Mahsa Yousefzadeh, Pinar Yurdakul-Mesutoglu, Murat Cagan, Mehmet Murat Seval, Doruk Cevdi Katlan, Klara Dalva, Mehmet Sinan Beksac, Meral Beksac
BACKGROUND: High self-renewal capacity and most permissive nature of umbilical cord blood (CB) results with successful transplant outcomes but low hematopoietic stem and progenitor cell (HSPC) counts limits wider use. In order to overcome this problem ex vivo expansion with small molecules such as Valproic acid (VPA) or Nicotinamide (NAM) have been shown to be effective. To the best of our knowledge, the combinatory effects of VPA and NAM on HSPC expansion has not been studied earlier...
March 1, 2024: Current Research in Translational Medicine
https://read.qxmd.com/read/38445374/biodistribution-and-safety-of-human-multi-chimeric-cells-hmcc-after-systemic-intraosseous-and-intravenous-administration-in-the-experimental-mouse-model
#20
JOURNAL ARTICLE
Maria Siemionow, Lucile Chambily, Joanna Cwykiel
Cellular therapies provide promising options for inducing tolerance in transplantation of solid organs, bone marrow, and vascularized composite allografts. However, novel tolerance-inducing protocols remain limited despite extensive research. We previously introduced and characterized a Human Multi-Chimeric Cell (HMCC) line, created through ex vivo fusion of human umbilical cord blood (UCB) cells derived from three unrelated donors. In this study, we assessed in vivo biodistribution and safety of HMCC in the NOD...
March 6, 2024: Stem Cells and Development
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