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Prostate Health Index

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https://www.readbyqxmd.com/read/28425193/health-related-quality-of-life-outcomes-from-a-contemporary-prostate-cancer-registry-in-a-large-diverse-population
#1
Gary W Chien, Jeff M Slezak, Teresa N Harrison, Howard Jung, Joy S Gelfond, Chengyi Zhang, Edward Wu, Richard Contreras, Ronald K Loo, Steven J Jacobsen
OBJECTIVE: To assess the health-related quality of life (HRQoL) of patients with prostate cancer up to 24 months after treatment in a contemporary large diverse population. PATIENTS AND METHODS: Patients with newly diagnosed prostate cancer from March 2011 to January 2014 in our healthcare system were included. The Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire was administered before treatment, and at 1, 3, 6, 12, 18, and 24 months after treatment up to November 2014 for all methods of treatment...
April 19, 2017: BJU International
https://www.readbyqxmd.com/read/28420168/comparative-study-of-blood-based-biomarkers-%C3%AE-2-3-sialic-acid-psa-and-phi-for-high-risk-prostate-cancer-detection
#2
Montserrat Ferrer-Batallé, Esther Llop, Manel Ramírez, Rosa Núria Aleixandre, Marc Saez, Josep Comet, Rafael de Llorens, Rosa Peracaula
Prostate Specific Antigen (PSA) is the most commonly used serum marker for prostate cancer (PCa), although it is not specific and sensitive enough to allow the differential diagnosis of the more aggressive tumors. For that, new diagnostic methods are being developed, such as PCA-3, PSA isoforms that have resulted in the 4K score or the Prostate Health Index (PHI), and PSA glycoforms. In the present study, we have compared the PHI with our recently developed PSA glycoform assay, based on the determination of the α2,3-sialic acid percentage of serum PSA (% α2,3-SA), in a cohort of 79 patients, which include 50 PCa of different grades and 29 benign prostate hyperplasia (BPH) patients...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28412653/the-relationship-between-dioxins-exposure-and-risk-of-prostate-cancer-with-steroid-hormone-and-age-in-vietnamese-men
#3
Xian Liang Sun, Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son
Although Vietnam's massive herbicide exposure in 1960s and 1970s was clearly injurious to health, not all causal relationships have been clarified. We therefore explored associations among dioxins, steroid hormones, age and prostate cancer risk in men. We compared serum levels of dioxin, steroid hormones and prostate specific antigen (PSA) in men aged 56-81years from herbicide-exposed hotspots (n=50) with those from non-sprayed regions (n=48). Mean serum levels of dioxin congeners in the hotspot group were 1...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28412335/metabolic-syndrome-does-not-increase-the-risk-of-ejaculatory-dysfunction-in-patients-with-lower-urinary-tract-symptoms-and-benign-prostatic-enlargement-an-italian-single-center-cohort-study
#4
Cosimo De Nunzio, Riccardo Lombardo, Mauro Gacci, Antonio Nacchia, Fabrizio Presicce, Hassan Alkhatatbeh, Sergio Serni, Andrea Tubaro
OBJECTIVES: To evaluate the relationship between metabolic syndrome and ejaculatory dysfunction in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: From 2012 to 2016, a consecutive series of men with LUTS and BPE attending our prostate clinic, evaluated with the International Prostatic Symptoms Score (IPSS) were enrolled into a prospective database. All patients were assessed using the short form of the International Index of Erectile Function (IIEF-SF) and the male sexual health questionnaire ejaculatory dysfunction short form (MSHQ-ejd-SF) which evaluates the ability to ejaculate, the ejaculation force, the ejaculation volume and subjective bother associated with ejaculatory dysfunction...
April 13, 2017: Urology
https://www.readbyqxmd.com/read/28384363/risk-of-second-primary-malignancies-among-patients-with-prostate-cancer-a-population-based-cohort-study
#5
Chao-Yueh Fan, Wen-Yen Huang, Chun-Shu Lin, Yu-Fu Su, Cheng-Hsiang Lo, Chih-Cheng Tsao, Ming-Yueh Liu, Cheng-Li Lin, Chia-Hung Kao
PURPOSE: The rising incidence and life expectancy associated with prostate cancer (PCa) has led to increasing interest in predicting the risk of second primary malignancies (SPMs) among PCa survivors, although data regarding SPMs after PCa are controversial. METHODS: We identified 30,964 patients from the National Health Insurance Research Database in Taiwan who had newly diagnosed PCa between 2000 and 2010. Each patient was randomly frequency-matched with an individual without PCa, based on age, comorbidity, and index year...
2017: PloS One
https://www.readbyqxmd.com/read/28379660/quality-of-life-after-post-prostatectomy-intensity-modulated-radiation-therapy-to-the-prostate-bed-with-or-without-the-use-of-gold-fiducial-markers-for-image-guidance-or-higher-total-radiotherapy-doses
#6
Yazan A Abuodeh, Arash O Naghavi, Tzu-Hua Juan, Zhenjun Ma, Richard B Wilder
PURPOSE: To evaluate quality of life (QoL) after post-prostatectomy intensity modulated radiation therapy (IMRT) in the "adjuvant" setting starting within 4 months of radical prostatectomy for adverse features; and "salvage" setting for a PSA≥0.2ng/mL. MATERIALS AND METHODS: Retrospective review of 130 patients who underwent IMRT to the prostate bed±gold fiducial marker placement for image guidance to 64.8-72.0Gy (median, 70.2Gy) between 2004 and 2013. Higher doses were defined as 70...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28378849/prediagnostic-enterolactone-concentrations-and-mortality-among-danish-men-diagnosed-with-prostate-cancer
#7
A K Eriksen, C Kyrø, N Nørskov, A K Bolvig, J Christensen, A Tjønneland, K Overvad, R Landberg, A Olsen
BACKGROUND/OBJECTIVES: Evidence on the role of diet in relation to prostate cancer progression is sparse. Foods rich in lignans have shown beneficial effects on prostate cancer progression in both animal studies and small human intervention studies, including beneficial effects on prostate-specific antigen levels and tumour growth. The lignan metabolite, enterolactone, has further shown to slow prostate cancer cell growth in vitro. The aim was to investigate the association between prediagnostic enterolactone concentrations and mortality among men with prostate cancer...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28368524/the-health-impact-of-adult-cervical-deformity-in-patients-presenting-for-surgical-treatment-comparison-to-united-states-population-norms-and-chronic-disease-states-based-on-the-euroquol-5-dimensions-questionnaire
#8
Justin S Smith, Breton Line, Shay Bess, Christopher I Shaffrey, Han Jo Kim, Gregory Mundis, Justin K Scheer, Eric Klineberg, Michael O'Brien, Richard Hostin, Munish Gupta, Alan Daniels, Michael Kelly, Jeffrey L Gum, Frank J Schwab, Virginie Lafage, Renaud Lafage, Tamir Ailon, Peter Passias, Themistocles Protopsaltis, Todd J Albert, K Daniel Riew, Robert Hart, Doug Burton, Vedat Deviren, Christopher P Ames, International Spine Study Group
BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database...
March 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28366670/improvement-of-voiding-characteristics-in-morbidly-obese-women-after-bariatric-surgery-a-single-center-study-with-a-1-year-follow-up
#9
Jae Heon Kim, Hwa Yeon Sun, Hyun Young Lee, Min Ju Soh, Suyeon Park, Yong Jin Kim, Yun Seob Song
BACKGROUND: It is well known that morbid obesity in women is related to lower urinary tract symptoms, including urinary incontinence. Although several studies have reported on the improvement in urinary incontinence after bariatric surgery, few reports have focused on the detailed changes in other voiding characteristics. OBJECTIVE: To demonstrate the real benefit of bariatric surgery on lower urinary tract symptoms. SETTING: Bariatric Center of Excellence and Health Promotion at Soonchunhyang University Hospital...
February 7, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28360985/relationship-between-alcohol-consumption-and-prostatic-hyperplasia-according-to-facial-flushing-after-drinking-in-korean-men
#10
Hak Sun Jang, Jong Sung Kim, Sung Soo Kim, Jin-Gyu Jung, Seok-Joon Yoon, HyunJu Yang, Hyun Chul Joung
BACKGROUND: The purpose of this study was to examine whether facial flushing after drinking influences the relationship between alcohol consumption and prostatic hyperplasia among Korean men. METHODS: The subjects were 957 Korean men (180 non-drinkers, 389 with drinking-related facial flushing, 388 without facial flushing) in the 40-69 age group, who underwent prostate ultrasound at the health promotion center of Chungnam National University Hospital between 2008 and 2014...
March 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28351193/measurement-of-serum-isoform-2-propsa-derivatives-shows-superior-accuracy-to-magnetic-resonance-imaging-in-the-diagnosis-of-prostate-cancer-in-patients-with-a-total-prostate-specific-antigen-level-of-2-10%C3%A2-ng-ml
#11
Kazuhiro Furuya, Takashi Kawahara, Masaki Narahara, Takashi Tokita, Sachi Fukui, Masashi Imano, Taku Mitome, Yusuke Ito, Koji Izumi, Kimito Osaka, Yumiko Yokomizo, Narihiko Hayashi, Hisashi Hasumi, Shintaro Nawata, Tsuyoshi Kawano, Masahiro Yao, Hiroji Uemura
OBJECTIVE: More accurate diagnostic procedures for prostate cancer are needed to avoid unnecessary biopsy due to the low specificity of prostate-specific antigen (PSA). Recent studies showed that the percentage of serum isoform [-2]proPSA (p2PSA) to free PSA (%p2PSA), the Prostate Health Index (PHI) and magnetic resonance imaging (MRI) were more accurate than PSA. The aim of this study was to test the accuracy of %p2PSA, PHI and MRI in discriminating patients with and without prostate cancer...
March 29, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28342935/interpreting-patient-reported-urinary-and-sexual-function-outcomes-across-multiple-validated-instruments
#12
Emily A Vertosick, Andrew J Vickers, Janet E Cowan, Jeanette M Broering, Peter R Carroll, Matthew R Cooperberg
INTRODUCTION: Comparing patient-reported outcomes such as urinary and erectile function across institutions is critical for prostate cancer research and quality assurance. Such comparisons are complicated by the use of different questionnaires. We aimed to develop a method to convert scores between four commonly used instruments. MATERIALS AND METHODS: Patient-reported data on urinary and sexual function were collected from 1,284 men with localized prostate cancer using the Expanded Prostate Index Composite (EPIC-26), UCLA Prostate Cancer Index (PCI), Sexual Health Inventory for Men (SHIM) and International Prostate Symptom Scale (IPSS) questionnaires...
March 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28338774/pleiotropy-robust-mendelian-randomization
#13
Hans van Kippersluis, Cornelius A Rietveld
Background: The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of genetic variants, a fundamental assumption of Mendelian randomization (the exclusion restriction) can always be contested...
February 22, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28337464/obesity-age-ethnicity-and-clinical-features-of-prostate-cancer-patients
#14
Victor J Wu, Darren Pang, Wendell W Tang, Xin Zhang, Li Li, Zongbing You
Approximately 36.5% of the U.S. adults (≥ 20 years old) are obese. Obesity has been associated with type 2 diabetes mellitus, cardiovascular disease, stroke, and several types of cancer. The present study included 1788 prostate cancer patients who were treated with radical prostatectomy at the Ochsner Health System, New Orleans, Louisiana, from January, 2001 to March, 2016. The patient's medical records were retrospectively reviewed. Body mass index (BMI), age, ethnicity (Caucasians versus African Americans), clinical stage, Gleason score, and prostate-specific antigen (PSA) levels were retrieved...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/28331166/-tadalafil-ameliorates-symptoms-of-patients-with-benign-prostatic-hyperplasia-complicated-by-chronic-pelvic-pain-syndrome
#15
Yoshinori Nishino, Kousei Miwa, Yoji Moriyama, Shigeru Fujihiro, Takako Masue, Mina Kikuchi, Chie Nakai, Takashi Deguchi
To examine the efficacy and safety of tadalafil in the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia with chronic pelvic pain syndrome, we treated 23 Japanese men with tadalafil 5 mg once daily for 4 weeks. The mean age of the participantswas58.7 yearsand the prostate volume was25. 2 ml. Significant improvementsin total International Prostatic Symptom Score, International Prostatic Symptom Score Quality of Life Index, total National Institutes of Health Chronic Prostatitis Symptom Index score, pain subscore, urinary symptom subscore, and quality of life impact subscore, were observed for tadalafil versus before treatment...
March 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28324093/association-between-radiation-therapy-surgery-or-observation-for-localized-prostate-cancer-and-patient-reported-outcomes-after-3-years
#16
COMPARATIVE STUDY
Daniel A Barocas, JoAnn Alvarez, Matthew J Resnick, Tatsuki Koyama, Karen E Hoffman, Mark D Tyson, Ralph Conwill, Dan McCollum, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Sherrie H Kaplan, Lisa E Paddock, Antoinette M Stroup, Xiao-Cheng Wu, David F Penson
Importance: Understanding the adverse effects of contemporary approaches to localized prostate cancer treatment could inform shared decision making. Objective: To compare functional outcomes and adverse effects associated with radical prostatectomy, external beam radiation therapy (EBRT), and active surveillance. Design, Setting, and Participants: Prospective, population-based, cohort study involving 2550 men (≤80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with prostate-specific antigen levels less than 50 ng/mL, and enrolled within 6 months of diagnosis...
March 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28322234/propsa-and-the-prostate-health-index-as-predictive-markers-for-aggressiveness-in-low-risk-prostate-cancer-results-from-an-international-multicenter-study
#17
I Heidegger, H Klocker, R Pichler, A Pircher, W Prokop, E Steiner, C Ladurner, E Comploj, A Lunacek, D Djordjevic, A Pycha, E Plas, W Horninger, J Bektic
BACKGROUND: One of the major challenges in prostate cancer (PCa) treatment is distinguishing insignificant PCa from those forms that need active treatment. We evaluated the impact of PSA isoforms on risk stratification in patients with low-risk PCa as well as in active surveillance (AS) candidates who underwent radical prostatectomy. METHODS: A total of 112 patients with biopsy confirmed Gleason score (GS) 6 PCa of four different international institutions were prospectively enrolled in the study...
March 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28295504/testosterone-therapy-has-positive-effects-on-anthropometric-measures-metabolic-syndrome-components-obesity-lipid-profile-diabetes-mellitus-control-blood-indices-liver-enzymes-and-prostate-health-indicators-in-elderly-hypogonadal-men
#18
O Canguven, R A Talib, W El Ansari, D-J Yassin, M Salman, A Al-Ansari
To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28282307/health-related-quality-of-life-after-the-diagnosis-of-locally-advanced-or-advanced-prostate-cancer-a-longitudinal-study
#19
Leah Zajdlewicz, Melissa K Hyde, Stephen J Lepore, Robert A Gardiner, Suzanne K Chambers
BACKGROUND: Approximately 20% of men with a diagnosis of prostate cancer present with locally advanced or advanced disease. Few studies consider longer-term impact of disease progression and treatment adverse effects on health-related quality of life (QoL) of these men. OBJECTIVE: Describe changes in health-related QoL over 5 years for men with newly diagnosed locally advanced or advanced prostate cancer. INTERVENTIONS/METHODS: Eighty-one men with locally advanced or advanced prostate cancer referred to the study by their treating urologist completed a self-administered questionnaire assessing distress, cancer-specific distress, decision regret, satisfaction with life, and global and disease-specific health-related QoL...
March 10, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28279996/incidence-and-relative-risk-for-developing-cancer-among-patients-with-copd-a-nationwide-cohort-study-in-taiwan
#20
Chung-Han Ho, Yi-Chen Chen, Jhi-Joung Wang, Kuang-Ming Liao
OBJECTIVES: This observational study aimed to examine the incidence of malignant diseases, including specific cancer types, after the diagnosis of chronic obstructive pulmonary disease (COPD) in Taiwanese patients. SETTING: Taiwan's National Health Insurance Research Database. PARTICIPANTS: The definition of a patient with COPD was a patient with a discharge diagnosis of COPD or at least 3 ambulatory visits for COPD. The index date was the date of the first COPD diagnosis...
March 9, 2017: BMJ Open
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