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Prostate Health Index

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https://www.readbyqxmd.com/read/29158509/clinical-utility-of-the-prostate-health-index-phi-for-biopsy-decision-management-in-a-large-group-urology-practice-setting
#1
Jay White, B Vittal Shenoy, Ronald F Tutrone, Lawrence I Karsh, Daniel R Saltzstein, William J Harmon, Dennis L Broyles, Tamra E Roddy, Lori R Lofaro, Carly J Paoli, Dwight Denham, Mark A Reynolds
BACKGROUND: Deciding when to biopsy a man with non-suspicious DRE findings and tPSA in the 4-10 ng/ml range can be challenging, because two-thirds of such biopsies are typically found to be benign. The Prostate Health Index (phi) exhibits significantly improved diagnostic accuracy for prostate cancer detection when compared to tPSA and %fPSA, however only one published study to date has investigated its impact on biopsy decisions in clinical practice. METHODS: An IRB approved observational study was conducted at four large urology group practices using a physician reported two-part questionnaire...
November 20, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29153462/health-related-quality-of-life-and-toxicity-after-single-fraction-19%C3%A2-gy-high-dose-rate-prostate-brachytherapy-phase-ii-trial
#2
Alfonso Gomez-Iturriaga, Francisco Casquero, Jose Ignacio Pijoan, Pablo Minguez, Jose Maria Espinosa, Ana Irasarri, Andrea Bueso, Jon Cacicedo, David Buchser, Pedro Bilbao
PURPOSE: To evaluate the safety, tolerance and impact on health-related-quality-of-life (HRQoL) of the high-dose-rate brachytherapy of 19 Gy (BRT-HDR-19 Gy) single fraction in prostate cancer. METHODS: From January 2014 to July 2016, 43 patients with low/intermediate risk were treated with BRT-HDR-19 Gy. The patients were monitored prospectively for toxicity and HRQoL. RESULTS: The median age, initial PSA and the International Prostate Symptom Score (IPSS) were 71 years (55-78), 7...
November 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29141559/new-histopathological-genetic-features-to-improve-active-surveillance-selection-for-low-risk-prostate-cancer
#3
Lih-Ming Wong, Kevin Chu, Niall Corcoran, Sam Norden
BACKGROUND: A recent surge in biomarkers to aid management of men with prostate cancer has occurred. Their applications are varied and not all tests are applicable to the active surveillance setting. OBJECTIVE: To review primary evidence on genetic and immunohistochemical biomarkers, and their role on patient selection and risk stratification for men on active surveillance for prostate cancer. EVIDENCE ACQUISITION: A PubMed electronic search using the terms (biomarker or genetic or histopathological) AND ("prostate cancer" AND "active surveillance") was performed from inception to April 2015...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29128730/socio-economic-inequalities-in-the-incidence-of-four-common-cancers-a-population-based-registry-study
#4
E J Tweed, G M Allardice, P McLoone, D S Morrison
OBJECTIVES: To investigate the relationship between socio-economic circumstances and cancer incidence in Scotland in recent years. STUDY DESIGN: Population-based study using cancer registry data. METHODS: Data on incident cases of colorectal, lung, female breast, and prostate cancer diagnosed between 2001 and 2012 were obtained from a population-based cancer registry covering a population of approximately 2.5 million people in the West of Scotland...
November 10, 2017: Public Health
https://www.readbyqxmd.com/read/29124247/chlamydia-trachomatis-versus-common-uropathogens-as-a-cause-of-chronic-bacterial-prostatitis-is-there-any-difference-results-of-a-prospective-parallel-cohort-study
#5
Tommaso Cai, Francesca Pisano, Gabriella Nesi, Vittorio Magri, Paolo Verze, Gianpaolo Perletti, Paolo Gontero, Vincenzo Mirone, Riccardo Bartoletti
Purpose: The role of Chlamydia trachomatis (CT) infection in chronic bacterial prostatitis (CBP) is well known. What is unclear is whether there are any differences in the course or clinical outcome of the disease when the cause is CT or other uropathogens. Materials and Methods: A series of 311 patients affected by CBP due to CT (cohort A) was compared with a group of 524 patients affected by CBP caused by common uropathogen bacteria (cohort B). All participants completed the following questionnaires: National Institutes of Health Chronic Prostatitis Symptom Index, International Prostate Symptom Score, International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD), Premature Ejaculation Diagnostic Tool (PEDT), and the Short Form 36 (SF-36) Health Survey...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29119583/hyperlipidemia-is-associated-with-an-increased-risk-of-clinical-benign-prostatic-hyperplasia
#6
Hung-Jen Shih, Chun-Jen Huang, Jui-An Lin, Ming-Chang Kao, Yen-Chun Fan, Pei-Shan Tsai
BACKGROUND: A high fat diet is associated with risk of benign prostatic hyperplasia (BPH). However, whether hyperlipidemia is associated with BPH remains unclear. This population-based cohort study elucidated whether hyperlipidemia is associated with an increased risk of BPH. METHODS: We used a new-exposure design and analyzed data retrieved from the Taiwan National Health Insurance Database between January 1, 2000 and December 31, 2013. The cohort of men with newly diagnosed hyperlipidemia and the age- and index-date-matched (1:3) nonhyperlipidemia cohort were tracked for incidence of BPH during a 1- to 14-year follow-up...
November 9, 2017: Prostate
https://www.readbyqxmd.com/read/29117111/the-vascular-factor-plays-the-main-role-in-the-cause-of-pain-in-men-with-chronic-prostatitis-and-chronic-pelvic-pain-syndrome-the-results-of-clinical-trial-on-thermobalancing-therapy
#7
Simon Allen
Chronic pain in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), NIH category III is difficult to treat without understanding its cause. The main symptom of chronic prostatitis is pain. In this study, we would like to explain the origin of pain in men with CP/CPPS and its therapy. Forty-five patients with CP/CPPS have received thermobalancing therapy (TT) enabled by Dr Allen's therapeutic device (DATD) for six months as mono-therapy. The control group comprised 45 men with CP/CPPS did not receive TT...
November 8, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29111200/quality-of-life-psychological-functioning-and-treatment-satisfaction-of-men-who-have-undergone-penile-prosthesis-surgery-following-robot-assisted-radical-prostatectomy
#8
Brindha Pillay, Daniel Moon, Christopher Love, Denny Meyer, Emma Ferguson, Helen Crowe, Nicholas Howard, Sarah Mann, Addie Wootten
BACKGROUND: Penile prosthesis surgery is last-line treatment to regaining erectile function after radical prostatectomy (RP) for localized prostate cancer. AIMS: To assess quality of life, psychological functioning, and treatment satisfaction of men who underwent penile implantation after RP; the psychosocial correlates of treatment satisfaction and sexual function after surgery; and the relation between patients' and partners' ratings of treatment satisfaction...
October 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29108306/the-prostate-health-index-phi-predicts-oncological-outcome-and-biochemical-recurrence-after-radical-prostatectomy-analysis-in-437-patients
#9
Andreas Maxeiner, Ergin Kilic, Julia Matalon, Frank Friedersdorff, Kurt Miller, Klaus Jung, Carsten Stephan, Jonas Busch
The purpose of this study was to investigate the Prostate-Health-Index (PHI) for pathological outcome prediction following radical prostatectomy and also for biochemical recurrence prediction in comparison to established parameters such as Gleason-score, pathological tumor stage, resection status (R0/1) and prostate-specific antigen (PSA). Out of a cohort of 460 cases with preoperative PHI-measurements (World Health Organization calibration: Beckman Coulter Access-2-Immunoassay) between 2001 and 2014, 437 patients with complete follow up data were included...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107268/whom-to-biopsy-prediagnostic-risk-stratification-with-biomarkers-nomograms-and-risk-calculators
#10
REVIEW
Stacy Loeb, Hasan Dani
This article describes markers used for prostate biopsy decisions, including prostrate-specific antigen (PSA), free PSA, the prostate health index, 4Kscore, PCA3, and ConfirmMDx. It also summarizes the use of nomograms combining multiple variables for prostate cancer detection.
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29106365/validation-of-the-french-canadian-version-of-the-expanded-prostate-cancer-index-composite-epic-in-a-french-canadian-population
#11
Éric Vigneault, Josée Savard, Marie-Hélène Savard, Hans Ivers, Philippe Després, William Foster, André-Guy Martin, Vincent Fradet
INTRODUCTION: This study aims to empirically validate the French-Canadian version of the Expanded Prostate Cancer Index Composite (EPIC), a measure of health-related quality of life for prostate cancer patients. METHODS: 251 participants completed a battery of self-report scales including the French-Canadian version of the EPIC, after having received radiation therapy or radical prostatectomy for prostate cancer. RESULTS: The internal consistency for the urinary incontinence, bowel, and sexual domains of the EPIC-26 was high (Cronbach's alpha coefficients from ...
November 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29104903/biomarkers-for-prostate-biopsy-and-risk-stratification-of-newly-diagnosed-prostate-cancer-patients
#12
Stacy Loeb
Introduction: Many new markers are now available as an aid for decisions about prostate biopsy for men without prostate cancer, and/or to improve risk stratification for men with newly diagnosed prostate cancer. Methods: A literature review was performed on currently available markers for use in decisions about prostate biopsy and initial prostate cancer treatment. Results: Although total prostate-specific antigen cutoffs were traditionally used for biopsy decisions, PSA elevations are not specific...
July 2017: Urology Practice
https://www.readbyqxmd.com/read/29099760/symptom-severity-following-rifaximin-and-the-probiotic-vsl-3-in-patients-with-chronic-pelvic-pain-syndrome-due-to-inflammatory-prostatitis-plus-irritable-bowel-syndrome
#13
Enzo Vicari, Michele Salemi, Giuseppe Sidoti, Mariano Malaguarnera, Roberto Castiglione
This study investigated the effects of long-term treatment with rifaximin and the probiotic VSL#3 on uro-genital and gastrointestinal symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) plus diarrhoea-predominant irritable bowel syndrome (D-IBS) compared with patients with D-IBS alone. Eighty-five patients with CP/CPPS (45 with subtype IIIa and 40 with IIIb) plus D-IBS according to the Rome III criteria and an aged-matched control-group of patients with D-IBS alone (n = 75) received rifaximin and VSL#3...
November 3, 2017: Nutrients
https://www.readbyqxmd.com/read/29072571/efficacy-of-thermobalancing-therapy-for-chronic-prostatitis-chronic-pelvic-pain-syndrome-confirmed-by-clinical-study-may-suggest-etiology-and-pathophysiology-of-this-disease
#14
Simon Allen, Ivan Gerasimovich Aghajanyan
INTRODUCTION: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) type-III is a common disorder characterized by pelvic pain and lower urinary tract symptoms in the absence of active infection. The aim of this clinical study is to evaluate the results of thermobalancing therapy (TT) and to discus the possible etiology and pathophysiology of CP/CPPS. METHODS: 45 patients with CP/CPPS used TT by applying therapeutic device, namely Dr Allen's therapeutic device (DATD), for six months as monotherapy...
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29072124/efficacy-of-low-intensity-extracorporeal-shock-wave-therapy-on-men-with-chronic-pelvic-pain-syndrome-refractory-to-3-as-therapy
#15
Shiao-Jin Guu, Jiun-Hung Geng, I-Ting Chao, Hui-Tzu Lin, Yung-Chin Lee, Yung-Shun Juan, Chia-Chu Liu, Chii-Jye Wang, Chia-Chun Tsai
Managing patients with chronic pelvic pain syndrome (CPPS) refractory to the traditional 3-As therapy (antibiotics, alpha-blockers, and anti-inflammatories) is a challenging task. Low-intensity extracorporeal shock wave therapy (LI-ESWT) was recently reported to be able to improve pain, urinary symptoms, and even sexual function by inducing neovascularization and anti-inflammation, reducing muscle tone, and influencing nerve impulses. This study evaluates whether combined treatment with LI-ESWT can restore clinical ability and quality of life (QoL) in patients refractory to 3-As therapy...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29050171/-use-of-prostate-health-index-in-diagnosing-prostate-cancer-in-chinese-men
#16
Y Zhu, B Tang, B Dai, X J Qin, X L Lu, D W Ye
Objective: To investigate the value of prostate health index (PHI) in the diagnosis of prostate cancer in patients with total prostate specific antigen (tPSA) <20 μg/L. Methods: Totally 1 135 patients with tPSA<20 μg/L and prostate biopsy indications at Department of Urology, Fudan University Shanghai Cancer Center from March 2013 to April 2016 were enrolled in this study. They were tested for serum tPSA, free prostate specific antigen and prostate specific antigen isoform 2, from which PHI was calculated...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29031767/cycling-and-male-sexual-and-urinary-function-results-from-a-large-multinational-cross-sectional-study
#17
Mohannad A Awad, Thomas W Gaither, Gregory P Murphy, Thanabhudee Chumnarnsongkhroh, Ian Metzler, Thomas Sanford, Siobhan Sutcliffe, Michael L Eisenberg, Peter R Carroll, E Charles Osterberg, Benjamin N Breyer
PURPOSE: To explore the relation between cycling and urinary and sexual function in a large, multinational sample of men. MATERIALS AND METHODS: Cyclists were recruited to complete a survey through Facebook advertisements and outreach to sporting clubs. Swimmers and runners were recruited as a comparison group. Cyclists were categorized into low and high intensity cyclists. Participants were queried using validated questionnaires, including the Sexual Health Inventory for Men (SHIM), International Prostate Symptom Score (I-PSS), and National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI), in addition to questions about urinary tract infections (UTIs), urethral strictures, genital numbness, and saddle sores...
October 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28986012/effect-of-patient-choice-and-hospital-competition-on-service-configuration-and-technology-adoption-within-cancer-surgery-a-national-population-based-study
#18
Ajay Aggarwal, Daniel Lewis, Malcolm Mason, Arnie Purushotham, Richard Sullivan, Jan van der Meulen
BACKGROUND: There is a scarcity of evidence about the role of patient choice and hospital competition policies on surgical cancer services. Previous evidence has shown that patients are prepared to bypass their nearest cancer centre to receive surgery at more distant centres that better meet their needs. In this national, population-based study we investigated the effect of patient mobility and hospital competition on service configuration and technology adoption in the National Health Service (NHS) in England, using prostate cancer surgery as a model...
October 3, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28975013/medication-adherence-treatment-patterns-and-dose-reduction-in-patients-with-metastatic-castration-resistant-prostate-cancer-receiving-abiraterone-acetate-or-enzalutamide
#19
Ajay S Behl, Lorie A Ellis, Dominic Pilon, Yongling Xiao, Patrick Lefebvre
BACKGROUND: The efficacy of and overall survival associated with metastatic castration-resistant prostate cancer (CRPC) treatments rely on patients' consistent adherence to the recommended dosage regimens. OBJECTIVES: To evaluate treatment patterns and patient adherence to abiraterone acetate or enzalutamide therapy in real-world practice, and to examine the factors that may be associated with medication dose reduction in patients with metastatic CRPC. METHODS: Retrospective analyses were conducted using the Truven Health MarketScan research databases among patients with metastatic CRPC who initiated treatment with abiraterone acetate or enzalutamide between October 1, 2012, and December 31, 2014 (index date)...
September 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28971702/-we-re-just-not-prepared-for-eating-over-our-whole-life-a-mixed-methods-approach-to-understanding-dietary-behaviors-among-longer-term-cancer-survivors
#20
Ann Carroll Klassen, Katherine Clegg Smith, Michelle Shuster, Kisha I Coa, Laura E Caulfield, Kathy J Helzlsouer, Kimberly S Peairs, Lillie D Shockney, Dara Stoney, Susan Hannum
BACKGROUND: In many countries, there are growing numbers of persons living with a prior diagnosis of cancer, due to the aging population and more successful strategies for treatment. There is also growing evidence of the importance of healthful diet and weight management for survivorship, yet many long-term cancer survivors are not successfully following recommendations. METHODS: We explored this issue in a mixed methods study with 53 adult survivors of 3 cancers (breast, prostate, and non-Hodgkin's lymphoma), living in Maryland...
September 1, 2017: Integrative Cancer Therapies
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