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Prostate Health Index

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https://www.readbyqxmd.com/read/28811062/validation-of-the-prostate-health-index-in-a-predictive-model-of-prostate-cancer
#1
A Sanchís-Bonet, M Barrionuevo-González, A M Bajo-Chueca, L Pulido-Fonseca, L E Ortega-Polledo, J C Tamayo-Ruiz, M Sánchez-Chapado
OBJECTIVES: To validate and analyse the clinical usefulness of a predictive model of prostate cancer that incorporates the biomarker «[-2] pro prostate-specific antigen» using the prostate health index (PHI) in decision making for performing prostate biopsies. MATERIAL AND METHODS: We isolated serum from 197 men with an indication for prostate biopsy to determine the total prostate-specific antigen (tPSA), the free PSA fraction (fPSA) and the [-2] proPSA (p2PSA)...
August 12, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28806263/18f-dcfbc-prostate-specific-membrane-antigen-targeted-pet-ct-imaging-in-localized-prostate-cancer-correlation-with-multiparametric-mri-and-histopathology
#2
Baris Turkbey, Esther Mena, Liza Lindenberg, Stephen Adler, Sandra Bednarova, Rose Berman, Anita T Ton, Yolanda McKinney, Philip Eclarinal, Craig Hill, George Afari, Sibaprasad Bhattacharyya, Ronnie C Mease, Maria J Merino, Paula M Jacobs, Bradford J Wood, Peter A Pinto, Martin G Pomper, Peter L Choyke
PURPOSE: To assess the ability of (N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-F-fluorobenzyl-L-cysteine) (F-DCFBC), a prostate-specific membrane antigen-targeted PET agent, to detect localized prostate cancer lesions in correlation with multiparametric MRI (mpMRI) and histopathology. METHODS: This Health Insurance Portability and Accountability Act of 1996-compliant, prospective, institutional review board-approved study included 13 evaluable patients with localized prostate cancer (median age, 62...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28804579/validity-of-prostate-health-index-and-percentage-of-2-pro-prostate-specific-antigen-as-novel-biomarkers-in-the-diagnosis-of-prostate-cancer-omani-tertiary-hospitals-experience
#3
Safana S Al Saidi, Nafila B Al Riyami, Mohammed S Al Marhoon, Mohammed S Al Saraf, Salim S Al Busaidi, Riad Bayoumi, Waad-Allah S Mula-Abed
OBJECTIVES: Prostate cancer is the leading cancer in older men. The Ministry of Health Oman Cancer Incidence Registry 2013 lists cancer of the prostate as the first most common cancer in males. Therefore, early detection is important and prostate-specific antigen (PSA) is widely used as an established laboratory test. However, despite its wide use, its value in screening, particularly in asymptomatic males, is controversial when considering the risks and benefits of early detection. METHODS: This prospective, observational study included 136 males (67...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28800293/rotating-shift-work-associated-with-obesity-in-men-from-northeastern-ontario
#4
Anne Grundy, Michelle Cotterchio, Victoria A Kirsh, Victoria Nadalin, Nancy Lightfoot, Nancy Kreiger
INTRODUCTION: While some studies have suggested associations between shift work and obesity, few have been population-based or considered multiple shift schedules. Since obesity is linked with several chronic health conditions, understanding which types of shift work influence obesity is important and additional work with more detailed exposure assessment of shift work is warranted. METHODS: Using multivariate polytomous logistic regression, we investigated the associations between shift work (evening/night, rotating and other shift schedules) and overweight and obesity as measured by body mass index cross-sectionally among 1561 men...
August 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28797178/mri-fusion-targeted-transrectal-prostate-biopsy-and-the-role-of-prostate-specific-antigen-density-and-prostate-health-index-for-the-detection-of-clinically-significant-prostate-cancer-in-southeast-asian-men
#5
Teck Wei Tan, Keng Siang Png, Chau Hung Lee, Arianto Yuwono, Yuyi Yeow, Kian-Tai Chong, Yee Mun Lee, Cher Heng Tan, Yung Khan Tan
OBJECTIVES: To test the hypothesis that targeted biopsy has a higher detection rate for clinically significant prostate (csPCa) than systematic biopsy. We defined csPCa as any Gleason sum ≥ 7 cancer. In patients with Prostate Imaging - Reporting and Data System (PI-RADS) 3 lesions, to determine if factors such as PSA density (PSAD) and prostate health index (PHI) can predict csPCa and help select patients for biopsy. MATERIALS AND METHODS: We report the first series of targeted biopsies in Southeast Asian men, with comparison against systematic biopsy...
August 11, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28795218/atopy-and-prostate-cancer-is-there-a-link-between-circulating-levels-of-ige-and-psa-in-humans
#6
Mieke Van Hemelrijck, Sophia N Karagiannis, Sabine Rohrmann
BACKGROUND: Atopy has been investigated as a potential risk factor for prostate cancer. IgE antibodies may be major players in protective responses against tumours, through engendering antigen presentation and enhancing adaptive immune responses targeted towards a specific allergen, but potentially also against tumour-associated antigens such as prostate-specific antigen (PSA). We therefore cross-sectionally investigated associations between circulating levels of PSA and IgE in the National Health and Nutrition Examination Survey 2005-2006...
August 9, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28780626/prospective-controlled-assessment-of-men-s-sexual-function-changes-following-holmium-laser-enucleation-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia
#7
Ahmed M Elshal, Ahmed El-Assmy, Ramy Mekkawy, Diaa-Eldin Taha, Ahmed R El-Nahas, Mahmoud Laymon, Hamdy El-Kappany, El-Housseiny Ibrahiem
OBJECTIVES: To assess how much Holmium laser enucleation of the prostate (HoLEP) is detrimental on men sexuality. METHODS: Between January and December 2013, all patients presented for BPH surgery were assessed using IIEF-15 (international index of erectile function-15) and Ej-MSHQ (ejaculatory domain-male sexual health questionnaire). Changes in men's sexuality following HoLEP in relation to control procedure were prospectively assessed. Intervention group included legible consecutive patients treated by HoLEP...
August 5, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28768262/clinical-evaluation-of-urine-prostatic-exosomal-protein-in-the-diagnosis-of-chronic-prostatitis
#8
Xiaojun Li, Ting Jiang, Feng Liu, Xuefeng Shao, Ye Xu, Weixin Sheng, Wei Sun
OBJECTIVE: To evaluate the clinical potential of urine prostatic exosomal protein (PSEP) as a diagnostic biomarker of chronic prostatitis (CP). Materials andmethods: Using an enzyme-linked immunosorbent assay kit, urine PSEP levels were detected in 103 control cases as well as 283 cases of CP, with 82 cases fulfilling the definition of the USA National Institutes of Health category II (NIH-II), 108 cases of NIH-IIIa and 93 cases of NIH-IIIb. The values of age, body mass index, prostate volume, serum prostatic specific antigen (PSA) urine PSEP levels, and seminal parameters were analyzed...
July 29, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28767447/prevalence-and-survival-prognosis-of-prostate-cancer-in-patients-with-end-stage-renal-disease-a-retrospective-study-based-on-the-korea-national-database-2003-2010
#9
Sung Han Kim, Jae Young Joung, Yoon Seok Suh, Young Ae Kim, Jin Hyuk Hong, Tong Sun Kuark, Eun Sook Lee, Kang Hyun Lee
OBJECTIVE: The study was aimed to evaluate the prevalence and prognosis of prostate cancer (PC) and end-stage renal disease (ESRD), determine the risk factors for overall survival (OS) and PC-specific survival (CSS), and evaluate differences in PC-related clinical therapeutic patterns between patients with and without PC-ESRD. METHODS: This observational population study, performed at the National Cancer Center and Cancer Research Institute in Korea, included patients with PC and ESRD from the nationwide Korean Health Insurance System and Korean Central Cancer Registry data...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753822/five-year-outcomes-for-a-prospective-randomised-controlled-trial-comparing-laparoscopic-and-robot-assisted-radical-prostatectomy
#10
Francesco Porpiglia, Cristian Fiori, Riccardo Bertolo, Matteo Manfredi, Fabrizio Mele, Enrico Checcucci, Stefano De Luca, Roberto Passera, Roberto Mario Scarpa
BACKGROUND: The literature is lacking randomised controlled trials comparing robot-assisted (RARP) and laparoscopic (LRP) radical prostatectomy, especially for follow-up >1 yr. OBJECTIVE: To report 5-yr outcomes for our previously published prospective randomised study comparing RARP and LRP. DESIGN, SETTING, AND PARTICIPANTS: From January 2010 to January 2011, 120 patients with organ-confined prostate cancer were enrolled and randomly assigned to RARP or LRP...
November 23, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28736746/malakoplakia-of-the-prostate-as-a-mimicker-of-prostate-cancer-on-prostate-health-index-and-magnetic-resonance-imaging-fusion-prostate-biopsy-a-case-report
#11
Nathaniel H Heah, Teck Wei Tan, Yung Khan Tan
Background: Isolated malakoplakia of the prostate is a rare inflammatory condition that has been clinically mistaken for prostatic malignancies. The development of Prostate Imaging Reporting and Data System (PI-RADS) classifications, and Prostate Health Index (PHI) has led to more accurate diagnosis of clinically significant disease and stratification of patients that may be at risk of prostate cancer. Case Presentation: We present a case of a 75-year-old male who was on follow-up with our hospital for elevated prostate specific antigen (PSA)...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#12
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
July 14, 2017: Urologia
https://www.readbyqxmd.com/read/28727906/potential-of-telmisartan-in-the-treatment-of-benign-prostatic-hyperplasia
#13
Ismail Ogunbayode Ishola, Charles C Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U Udokwu
Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced-BPH in rats. Fifty-four male Wistar rats (200 - 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1- vehicle normal, olive oil (10 ml/kg); group 2- BPH model control (10 ml/kg); groups 3-5 - telmisartan (5, 10 or 20 mg/kg, respectively); group 6- pioglitazone (20 mg/kg); group 7- celecoxib (20 mg/kg); group 8- combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9- combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg)...
July 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28725596/utility-of-trigger-point-injection-as-an-adjunct-to-physical-therapy-in-men-with-chronic-prostatitis-chronic-pelvic-pain-syndrome
#14
Nicholas N Tadros, Anup B Shah, Daniel A Shoskes
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is often associated with pelvic floor muscle spasm. While pelvic floor physical therapy (PFPT) is effective, some men are unable to resolve their symptoms and have residual trigger points (TPs). TP injection has been used for treatment in several neuromuscular pain syndromes. The objective of this study was to examine the efficacy and side effects of TP injection in men with CP/CPPS and pelvic floor spasm refractory to PT...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28724322/predictors-of-urinary-incontinence-between-abdominal-obesity-and-non-obese-male-adults
#15
Dongmei Li, Yi Xu, Qingbin Nie, Yan Li, Gengsheng Mao
OBJECTIVES: To investigate factors that may be associated with urinary incontinence (UI) in abdominal obese and non-obese adult males. METHODS: Data were analyzed for 2671 men (≥40 years of age) who participated in the National Health and Nutrition Examination Survey (2005-2008). We define abdominal obesity as a waist circumference >102 cm. Men with Incontinence Severity Index ≥3 were defined as having UI. Logistic regression analyses were used to identify factors associated with stress and urge UI...
July 20, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28721886/effect-of-eischens-yoga-during-radiation-therapy-on-prostate-cancer-patient-symptoms-and-quality-of-life-a-randomized-phase-ii-trial
#16
RANDOMIZED CONTROLLED TRIAL
Avital Mazar Ben-Josef, Jerry Chen, Paul Wileyto, Abigail Doucette, Justin Bekelman, John Christodouleas, Curtiland Deville, Neha Vapiwala
PURPOSE: A randomized phase II study was performed to measure the potential therapeutic effects of yoga on fatigue, erectile dysfunction, urinary incontinence, and overall quality of life (QOL) in prostate cancer (PCa) patients undergoing external beam radiation therapy (RT). METHODS AND MATERIALS: The participants were randomized to yoga and no-yoga cohorts (1:1). Twice-weekly yoga interventions were offered throughout the 6- to 9-week courses of RT. Comparisons of standardized assessments were performed between the 2 cohorts for the primary endpoint of fatigue and the secondary endpoints of erectile dysfunction, urinary incontinence, and QOL before, during, and after RT...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28701725/prospective-study-on-association-of-prostatic-calcifications-with-clinical-symptoms-and-results-of-treatment-in-men-with-type-iii-prostatitis
#17
Xiang Fei, Wei Jin, Shengyu Hua, Yan Song
The purpose is to investigate the clinical significance of prostatic calculi in patients with chronic prostatitis and to discuss the possible treatment.The data from 277 young males with CP/CPPS were analyzed prospectively. Symptom severity was measured using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostatic Symptoms Score (IPSS). Sexual function was assessed by the International Index of Erectile Function (IIEF-5) questionnaire. After four weeks of therapy, the NIH-CPSI, IPSS, and IIEF-5 tests were repeated...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698340/leisure-time-physical-activity-and-circulating-25-hydroxyvitamin-d-levels-in-cancer-survivors-a-cross-sectional-analysis-using-data-from-the-us-national-health-and-nutrition-examination-survey
#18
Lin Yang, Adetunji T Toriola
OBJECTIVES: Circulating 25-hydroxyvitamin D (25-OHD) is associated with improved cancer prognosis in some studies, yet it may be a surrogate marker for physical activity. We investigated the associations of leisure-time physical activity (LTPA) with circulating 25-OHD levels in cancer survivors, and determined whether associations differ by indoor and outdoor activity. DESIGN: Cross-sectional study. SETTING: The US National Health and Nutrition Examination Survey (NHANES)...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697533/predictors-of-operative-time-during-radical-retropubic-prostatectomy-and-robot-assisted-laparoscopic-prostatectomy
#19
Ross M Simon, Lauren E Howard, Daniel M Moreira, Martha K Terris, Christopher J Kane, William J Aronson, Christopher L Amling, Matthew R Cooperberg, Stephen J Freedland
OBJECTIVES: To better predict operative time using patient/surgical characteristics among men undergoing radical retropubic prostatectomy or robot-assisted laparoscopic prostatectomy in order to achieve more efficient operative scheduling and potentially decrease costs in the Veterans Health System. METHODS: We analyzed 2619 men treated with radical retropubic prostatectomy (n = 2005) or robot-assisted laparoscopic prostatectomy (n = 614) from 1993 to 2013 from six Veterans Affairs Hospitals in the Shared Equal Access Regional Cancer Hospital database...
August 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28687144/re-the-prostate-health-index-adds-predictive-value-to-multi-parametric-mri-in-detecting-significant-prostate-cancers-in-a-repeat-biopsy-population
#20
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