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JOURNAL ARTICLE
Marcin Siwek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Adrian Gerlich, Andrzej Juryk, Dominika Dudek
OBJECTIVES: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used drugs to treat major depressive disorder (MDD). However, about 50% of MDD patients do not achieve treatment response to SSRIs and there is little evidence on which drugs are effective as second-line treatment in those who do not respond to SSRIs. METHODS: In this work, the data of 79 patients with MDD were analyzed to evaluate the effectiveness of trazodone XR in the group of individuals treated de novo and those switched to trazodone XR after failed treatment attempt with SSRIs...
December 1, 2023: Psychiatria Polska
#22
JOURNAL ARTICLE
Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang
BACKGROUND: Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown. AIMS: To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain. METHODS: Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software...
2024: General Psychiatry
#23
JOURNAL ARTICLE
Ming Xu, Xuemei Li, Teng Teng, Yang Huang, Mengqi Liu, Yicheng Long, Fajin Lv, Dongmei Zhi, Xiang Li, Aichen Feng, Shan Yu, Vince Calhoun, Xinyu Zhou, Jing Sui
IMPORTANCE: Adolescent major depressive disorder (MDD) is associated with serious adverse implications for brain development and higher rates of self-injury and suicide, raising concerns about its neurobiological mechanisms in clinical neuroscience. However, most previous studies regarding the brain alterations in adolescent MDD focused on single-modal images or analyzed images of different modalities separately, ignoring the potential role of aberrant interactions between brain structure and function in the psychopathology...
March 4, 2024: JAMA Network Open
#24
JOURNAL ARTICLE
Yingying Chen, Xiaodi Xia, Zheyi Zhou, Meng Yuan, Yadong Peng, Ying Liu, Jinxiang Tang, Yixiao Fu
Inflammatory mechanisms may play crucial roles in the pathophysiology of major depressive disorder (MDD), and cytokine concentrations are correlated with brain alterations. Adolescents and young adults with MDD have higher recurrence and suicide rates than adults, but there has been limited research on the underlying mechanisms. In this study, we aimed to investigate the potential correlations among cytokines, depression severity, and the volumes of the amygdala, hippocampus, and nucleus accumbens in Han Chinese adolescents and young adults with first-episode MDD...
March 12, 2024: Brain Imaging and Behavior
#25
Anthony J Deo, Victor M Castro, Ashley Baker, Devon Carroll, Joseph Gonzalez-Heydrich, David C Henderson, Daphne J Holt, Kimberly Hook, Rakesh Karmacharya, Joshua L Roffman, Emily M Madsen, Eugene Song, William G Adams, Luisa Camacho, Sarah Gasman, Jada S Gibbs, Rebecca G Fortgang, Chris J Kennedy, Galina Lozinski, Daisy C Perez, Marina Wilson, Ben Y Reis, Jordan W Smoller
BACKGROUND AND HYPOTHESIS: Early detection of psychosis is critical for improving outcomes. Algorithms to predict or detect psychosis using electronic health record (EHR) data depend on the validity of the case definitions used, typically based on diagnostic codes. Data on the validity of psychosis-related diagnostic codes is limited. We evaluated the positive predictive value (PPV) of International Classification of Diseases (ICD) codes for psychosis. STUDY DESIGN: Using EHRs at three health systems, ICD codes comprising primary psychotic disorders and mood disorders with psychosis were grouped into five higher-order groups...
February 29, 2024: medRxiv
#26
JOURNAL ARTICLE
Junjun Liu, Yangchun Wang, Wei Mu, Yang Liu, Ruixiang Tong, Zhaomin Lu, Hsinsung Yuan, Fengnan Jia, Xiaobin Zhang, Zhe Li, Wanqiu Yang, Xiangdong Du, Xiangyang Zhang
OBJECTIVE: Major depressive disorder (MDD) sufferers frequently have psychotic symptoms, yet the underlying triggers remain elusive. Prior research suggests a link between insulin resistance (IR) and increased occurrence of psychotic symptoms. Hence, this study sought to investigate the potential association between psychotic symptoms in Chinese patients experiencing their first-episode drug-naïve (FEDN) MDD and the triglyceride glucose (TyG) index, an alternative measure of insulin resistance (IR)...
2024: Frontiers in Psychiatry
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JOURNAL ARTICLE
Hui Chen, Jinfeng Wang, Shurui Chen, Xianliang Chen, Jiali Liu, Huajia Tang, Jiawei Zhou, Yusheng Tian, Xiaoping Wang, Xia Cao, Jiansong Zhou
The purpose of this study was to explore the metabolomic differences between Major depressive disorder (MDD) and healthy individuals among adolescents and the association between childhood maltreatment (CM) and differentially abundant metabolites. The exploratory study included 40 first-episode drug-naïve adolescents with MDD and 20 healthy volunteers. We used the Beck Depression Inventory (BDI-13) to assess the severity of depression and the Childhood Trauma Questionnaire (CTQ) to assess the presence of childhood maltreatment...
February 16, 2024: Psychiatry Research
#28
JOURNAL ARTICLE
Peishan Dai, Yun Shi, Da Lu, Ying Zhou, Jialin Luo, Zhuang He, Zailiang Chen, Beiji Zou, Hui Tang, Zhongchao Huang, Shenghui Liao
BACKGROUND AND OBJECTIVE: Recurrent major depressive disorder (rMDD) has a high recurrence rate, and symptoms often worsen with each episode. Classifying rMDD using functional magnetic resonance imaging (fMRI) can enhance understanding of brain activity and aid diagnosis and treatment of this disorder. METHODS: We developed a Residual Denoising Autoencoder (Res-DAE) framework for the classification of rMDD. The functional connectivity (FC) was extracted from fMRI data as features...
March 2, 2024: Computer Methods and Programs in Biomedicine
#29
JOURNAL ARTICLE
Kerry B O'Leary, Katrina A Rufino, Michelle A Patriquin, Shweta Kapoor
Transgender youth are at an increased risk of suicide, substance use, experiencing violent assaults, and reporting major depressive episodes and greater psychological distress compared to their cisgender counterparts. This study examined mental health symptom severity in adolescents admitted to an inpatient psychiatric hospital who wished they were of a different gender compared to those who did not. A group of 180 adolescents admitted to an inpatient psychiatric hospital completed assessments to measure mental health symptom severity at admission...
March 6, 2024: Child Psychiatry and Human Development
#30
JOURNAL ARTICLE
Zhaosong Chu, Lijin Yuan, Kun Lian, Mengxin He, Yi Lu, Yuqi Cheng, Xiufeng Xu, Zonglin Shen
BACKGROUND: Melancholic depression (MD) is one of the most prevalent and severe subtypes of major depressive disorder (MDD). Previous studies have revealed inconsistent results regarding alterations in grey matter volume (GMV) of the hippocampus and amygdala of MD patients, possibly due to overlooking the complexity of their internal structure. The hippocampus and amygdala consist of multiple and functionally distinct subregions, and these subregions may play different roles in MD. This study aims to investigate the volumetric alterations of each subregion of the hippocampus and amygdala in patients with MD and non-melancholic depression (NMD)...
March 5, 2024: BMC Psychiatry
#31
JOURNAL ARTICLE
Abbas F Almulla, Ali Abbas Abo Algon, Michael Maes
This research assessed the effects of adverse childhood experiences (ACEs) and negative life events (NLEs) on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD patients and forty heathy controls. ACEs are highly significantly associated with the classical M1 macrophage, T helper (Th)-1, Th-1 polarization, IRS, and neurotoxicity immune profiles, and not with the alternative M2, and Th-2 immune profiles. There are highly significant correlations between ACEs and NLEs and different cytokines/chemokines/growth factors, especially with interleukin (IL)-16, CCL27, stem cell growth factor, and platelet-derived growth factor...
February 29, 2024: Psychiatry Research
#32
JOURNAL ARTICLE
Xingling He, Donghua Liu, Shihao Ni, Ziru Li, Sijing Li, Tingchun Wu, Xiaoming Dong, Xiaojiao Zhang, Yaqin Tang, Yan Ling, Huili Liao, Jinhua Kang, Yue Li, Hongyan Wu, Jing Luo, Xianming Wan, Dan Zhang, Lu Lu, Wenjie Long, Zhongqi Yang
BACKGROUND: Stable angina pectoris (SAP) is a clinical condition characterized by reversible and temporary myocardial ischemia and hypoxia. A majority of SAP patients also experience depressive disorders, which adversely affect their disease prognosis and overall quality of life. However, the clinical utility of existing antidepressants is constrained by their side effects. Ginkgo biloba dropping pill (GBDP), a Chinese patented medication, has demonstrated efficacy in the treatment of both coronary heart disease and mental disorders...
January 11, 2024: Phytomedicine
#33
JOURNAL ARTICLE
Baolin Wu, Xun Zhang, Hongsheng Xie, Xiuli Wang, Qiyong Gong, Zhiyun Jia
PURPOSE: Major depressive disorder (MDD) tends to emerge during adolescence, but the neurobiology of adolescent MDD is still poorly understood. This study aimed to explore the topological organization of white matter structural networks and the relationship between structural and functional connectivity in adolescent MDD. METHODS: Structural and functional magnetic resonance imaging data were acquired from 94 first-episode drug-naïve adolescent MDD patients and 78 healthy adolescents...
February 28, 2024: Journal of Adolescent Health
#34
JOURNAL ARTICLE
Qingyan Jiao, Yeqing Dong, Xiaojuan Ma, Shiyi Suzy Ji, Xinyu Liu, Jian Zhang, Xia Sun, Dazhi Li, Xingguang Luo, Yong Zhang
PURPOSE: Major depressive disorder (MDD) is associated with worse cognitive functioning. We aim to examine the association between baseline cognitive functioning and the reduction rate in HDRS-17 total scores and to highlight the predictors of the reduction rate in HDRS-17 total scores in MDD with first-episode, drug-naïve (FED) patients. PATIENTS AND METHODS: Ninety FED patients were recruited consecutively and evaluated using the 17-item Hamilton Depression Rating Scale (HDRS-17), the 14-item Hamilton Anxiety Scale (HAMA-14), the Functioning Assessment Short Test (FAST) and the MATRICS Consensus Cognitive Battery (MCCB) at baseline and again at week 8...
2024: Neuropsychiatric Disease and Treatment
#35
JOURNAL ARTICLE
Joaquín Gil-Badenes, Anna Giménez-Palomo, Lucía Duque, Gabriel Pujol-Fontrodona, Erika Martínez-Amorós, Miquel Bioque
OBJECTIVES: This study aims to conduct a descriptive analysis of the clinical features and treatment responses in 6 patients with catatonia who received maintenance electroconvulsive therapy (ECT). METHODS: Our study included all patients who underwent maintenance ECT (mECT) at the Hospital Clínic de Barcelona between September 2020 and September 2022 following a catatonic episode. RESULTS: The study cohort comprised 5 patients with schizophrenia and 1 patient with major depressive disorder...
February 27, 2024: Journal of ECT
#36
Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, Jonathan R I Coleman, Darsol Seok, Janos Kalman, Philip B Mitchell, Peter R Schofield, Andreas J Forstner, Michael Bauer, Laura J Scott, Carlos N Pato, Michele T Pato, Qingqin S Li, George Kirov, Mikael Landén, Lina Jonsson, Bertram Müller-Myhsok, Jordan W Smoller, Elisabeth B Binder, Tanja M Brückl, Darina Czamara, Sandra Van der Auwera, Hans J Grabe, Georg Homuth, Carsten O Schmidt, James B Potash, Raymond J DePaulo, Fernando S Goes, Dean F MacKinnon, Francis M Mondimore, Myrna M Weissman, Jianxin Shi, Mark A Frye, Joanna M Biernacka, Andreas Reif, Stephanie H Witt, René R Kahn, Marco M Boks, Michael J Owen, Katherine Gordon-Smith, Brittany L Mitchell, Nicholas G Martin, Sarah E Medland, Lisa Jones, James A Knowles, Douglas F Levinson, Michael C O'Donovan, Cathryn M Lewis, Gerome Breen, Thomas Werge, Andrew J Schork, Roel Ophoff, Stephan Ripke, Loes Olde Loohuis
BACKGROUND: Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that the first manic episode is often preceded by a depressive one, making it difficult to distinguish BD from unipolar major depressive disorder (MDD). AIMS: Here, we use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores that may aid early differential diagnosis...
January 30, 2024: medRxiv
#37
JOURNAL ARTICLE
Ugnė Grigaitė, Sofia Azeredo-Lopes, Graça Cardoso, Bárbara Pedrosa, Deborah Oyine Aluh, Margarida Santos-Dias, Manuela Silva, Miguel Xavier, José Miguel Caldas-de-Almeida
The aim of this article is to study mental health conditions among survivors of severe physical intimate partner violence (IPV) and their utilisation of mental health services. This study is an integrated part of the World Mental Health Survey Initiative-Portugal, for which data was collected from a nationally representative adult sample using well-validated scales. Logistic regression models were used in the analysis. The most common statistically significant mental health conditions among IPV survivors were suicide ideation, PTSD, major depressive episode, and generalised anxiety disorder...
February 17, 2024: Psychiatry Research
#38
JOURNAL ARTICLE
Wenqi Gao, Zhifang Deng, Xiaonan Cai, Dan Zhang, Han Xiao, Xiangyang Zhang
BACKGROUND: Although gender differences in major depressive disorder (MDD) have been widely reported, there has not been much focus on gender differences in comorbidity. In patients with MDD and comorbid metabolic syndrome (Mets), the goal of this study was to investigate potential gender differences in the prevalence and clinical correlates of concomitant anxiety. METHODS: Seven hundred and ninety-four first-episode and drug-naïve patients (FEDN) patients with MDD and comorbid Mets were recruited...
February 22, 2024: BMC Psychiatry
#39
JOURNAL ARTICLE
Peiwei Xu, Yuanmei Tao, Hang Zhang, Meijiang Jin, Hanmei Xu, Shoukang Zou, Fang Deng, Lijuan Huang, Hong Zhang, Xiaolan Wang, Xiaowei Tang, Yanping Wang, Li Yin, Xueli Sun
Objective: Adolescent suicide is a major public health problem, and risk of suicide is higher among those with major depressive disorder (MDD), which may be linked to alterations in mitogen- and stress-activated kinase 1 (MSK1) and to defects in executive function. Here, we aimed to investigate the potential impacts of executive function and MSK1 methylation on suicidal ideation in adolescents with MDD. Methods: The study enrolled 66 drug-naive adolescents who were experiencing their first episode of MDD from February 2019 until October 2020...
February 21, 2024: Journal of Clinical Psychiatry
#40
JOURNAL ARTICLE
Marlijn E Besten, Marieke van Vugt, Harriëtte Riese, Claudi L H Bockting, Brian D Ostafin, André Aleman, Marie-José van Tol
BACKGROUND: Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, and involves high relapse rates in which persistent negative thinking and rumination (i.e., perseverative cognition [PC]) play an important role. Positive fantasizing and mindfulness are common evidence-based psychological interventions that have been shown to effectively reduce PC and subsequent depressive relapse. How the interventions cause changes in PC over time, is unknown, but likely differ between the two...
February 19, 2024: BMC Psychiatry
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