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First Major Depressive Episode

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https://www.readbyqxmd.com/read/29034588/clinical-and-demographic-differences-between-patients-with-manic-depressive-and-schizophrenia-spectrum-psychoses-presenting-to-early-intervention-services-in-london
#1
Adisha Kapila, Helen L Fisher, Sonia Johnson, Barnaby Major, Nikola Rahaman, John Joyce, Nick Chamberlain-Kent, Jo Lawrence, Allan H Young, James M Stone
AIM: To investigate the relationship between the presenting clinical and demographic characteristics in first-episode psychosis (FEP) patients with their clinical diagnostic grouping 1 year later. METHODS: Data from 1014 first-presentation psychosis patients from seven London-based Early Intervention Services were extracted from the MiData audit database. Associations between clinical and demographic measures at presentation and clinical diagnosis made at 1 year were assessed with analysis of variance (ANOVA) and Chi-square tests...
October 15, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28988102/number-of-illness-episodes-as-predictor-of-residual-symptoms-in-major-depressive-disorder
#2
Gianluca Serafini, Jacopo Nebbia, Nicolò Cipriani, Claudia Conigliaro, Denise Erbuto, Maurizio Pompili, Mario Amore
Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#3
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28958916/how-can-the-depressed-mind-extract-and-remember-predictive-relationships-of-the-environment-evidence-from-implicit-probabilistic-sequence-learning
#4
Karolina Janacsek, Emőke Borbély-Ipkovich, Dezso Nemeth, Xénia Gonda
A growing body of evidence suggests that emotion and cognition are fundamentally intertwined; impairments in explicit, more effortful and attention-dependent cognitive functions have widely been observed in negative mood. Here we aimed to test how negative mood affects implicit cognition that is less susceptible to motivational and attentional factors associated with negative mood. Therefore, we examined implicit learning and retention of predictive relationships in patients with major depressive episode (MDE)...
September 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28958613/assessing-the-serum-concentration-levels-of-nt-4-5-gpx-1-tnf-%C3%AE-and-l-arginine-as-biomediators-of-depression-severity-in-first-depressive-episode-patients-with-and-without-posttraumatic-stress-disorder
#5
Ewa A Ogłodek, Marek J Just, Adam R Szromek, Aleksander Araszkiewicz
BACKGROUND: Neurotrophin-4/5 (NT-4/5) and glutathione peroxidase-1 (GPX-1) have been shown to play a major role in neuronal processes including depression and posttraumatic stress disorder (PTSD). They protect the body from oxidative damage by affecting neuronal growth, development and plasticity. The aim of the study was to evaluate the concentrations of NT-4/5, GPX-1, tumor necrosis factor-α (TNF-α), and l-arginine in patients suffering from varying levels of depression severity, PTSD, and depression comorbid with PTSD...
May 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28938513/increased-anterior-default-mode-network-homogeneity-in-first-episode-drug-naive-major-depressive-disorder-a-replication-study
#6
Wenbin Guo, Xilong Cui, Feng Liu, Jindong Chen, Guangrong Xie, Renrong Wu, Zhikun Zhang, Huafu Chen, Jingping Zhao
BACKGROUND: Abnormal default-mode network (DMN) homogeneity has been involved in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. The inconsistency may be due to clinical and methodological variability, and the reproducibility of the findings is limited. The present study aimed to examine alterations of the DMN homogeneity in two independent samples of patients with first-episode, drug-naive MDD. METHODS: The samples included 59 patients with MDD and 31 comparison subjects from Sample 1 and 29 patients with MDD and 24 comparison subjects from Sample 2...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28915082/a-combined-study-of-slc6a15-gene-polymorphism-and-the-resting-state-functional-magnetic-resonance-imaging-in-first-episode-drug-naive-major-depressive-disorder
#7
Lijuan Wang, Zhifen Liu, Xiaohua Cao, Jianying Li, Aixia Zhang, Ning Sun, Chunxia Yang, Kerang Zhang
AIMS: The SLC6A15 gene has been identified as a novel candidate gene for major depressive disorder (MDD). However, the mechanism underlying the effects of how the SLC6A15 gene affects functional brain activity of patients with MDD remains unknown. METHODS: In the present study, we investigated the effect of the SLC6A15 gene polymorphism, rs1545843, on resting-state brain function in MDD with the imaging genomic technology and the regional homogeneity (ReHo) method...
September 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28910601/identification-of-plasma-biomarkers-for-distinguishing-bipolar-depression-from-major-depressive-disorder-by-itraq-coupled-lc-ms-ms-and-bioinformatics-analysis
#8
Juanjuan Ren, Guoqing Zhao, Xiujia Sun, Hongmei Liu, Ping Jiang, Jun Chen, Zhiguo Wu, Daihui Peng, Yiru Fang, Chen Zhang
It is important to differentiate between bipolar disorder (BD) and major depressive disorder (MDD) in the first depressive episode because of the potential treatment implications. Previous studies have mainly focused on the different clinical features or pathological biomarkers to distinguish these two diseases; however, a better understanding of the proteomics profiling of BD may help aid future therapeutic strategies. Here, we applied isobaric tags for relative and absolute quantification (iTRAQ) technology combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify differentially expressed proteins between MDD and bipolar depression (BP)...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28886500/peripheral-proinflammatory-cytokines-in-chinese-patients-with-generalised-anxiety-disorder
#9
Zhen Tang, Gang Ye, Xinyun Chen, Mingzhi Pan, Jialin Fu, Tian Fu, Qichun Liu, Zhenyong Gao, David S Baldwin, Ruihua Hou
BACKGROUND: Inflammatory responses and inflammatory cytokines have been implicated in the pathogenesis of affective disorders, particularly major depression. Given the limited evidence relating to the potential role of proinflammatory cytokines in generalised anxiety disorder (GAD), we aimed to examine peripheral proinflammatory cytokines in Chinese patients with GAD. METHODS: A case-controlled cross-sectional study design, with recruitment of 48 patients with first episode GAD and 48 matched healthy controls...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28871117/conjoint-and-dissociated-structural-and-functional-abnormalities-in-first-episode-drug-naive-patients-with-major-depressive-disorder-a-multimodal-meta-analysis
#10
Weina Wang, Youjin Zhao, Xinyu Hu, Xiaoqi Huang, Weihong Kuang, Su Lui, Graham J Kemp, Qiyong Gong
Published MRI evidence of structural and resting-state functional brain abnormalities in MDD has been inconsistent. To eliminate interference by repeated disease episodes and antidepressant treatment, we conducted the first multimodal voxel-wise meta-analysis of studies of voxel-based morphometry (VBM) and the amplitude of low-frequency fluctuation (ALFF) in first-episode drug-naive MDD patients, using the Seed-based d Mapping method (SDM). Fifteen VBM data sets and 11 ALFF data sets were included. SDM-based multimodal meta-analysis was used to highlight brain regions with both structural and functional abnormalities...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867409/what-characteristics-are-associated-with-earlier-onset-of-first-depressive-episodes-a-16-year-follow-up-of-a-national-population-based-cohort
#11
Xiangfei Meng
This study examined characteristics associated with earlier onset of first depressive episodes. A nationally representative Canadian sample was randomly selected and followed from 1994 to 2011. At baseline complete data on depression history (Yes/No) and related diseases was available for 12,227 study subjects. Proportional hazard models were used. Meta-analyses were also applied to sync results across studies. Being younger, a woman, a Caucasian, a regular smoker, and having a chronic disease were significantly associated with the expedited trajectory for the onset of the first depressive episode...
August 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28860879/association-of-perfectionistic-and-dependent-dysfunctional-attitudes-with-subthreshold-depression
#12
Satoshi Horiuchi, Shuntaro Aoki, Koki Takagaki, Fumihito Shoji
BACKGROUND: Dysfunctional attitudes are beliefs and attitudes that induce negative thoughts about the self, others, and the future, leading to depression. Perfectionistic dysfunctional attitudes are beliefs and attitudes about achievement and excessive fear of failure, while dependent dysfunctional attitudes are beliefs and attitudes about dependency on, and approval from, others. Subthreshold depression refers to a depressive state that does not meet the diagnostic criteria for a major depressive episode...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28860772/factors-associated-with-failure-to-achieve-remission-and-with-relapse-after-remission-in-patients-with-major-depressive-disorder-in-the-perform-study
#13
Delphine Saragoussi, Maëlys Touya, Josep Maria Haro, Bengt Jönsson, Martin Knapp, Bastien Botrel, Ioana Florea, Henrik Loft, Benoît Rive
BACKGROUND: The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28860564/differential-effects-of-antidepressant-treatment-on-long-range-and-short-range-functional-connectivity-strength-in-patients-with-major-depressive-disorder
#14
Jing An, Li Wang, Ke Li, Yawei Zeng, Yunai Su, Zhen Jin, Xin Yu, Tianmei Si
Although we have some basic understanding of the neurochemical mechanisms of the antidepressants, the network-level effect of antidepressant treatment is still not fully understood. This study was conducted to investigate the effects of antidepressant on functional brain networks of patients with major depressive disorder (MDD). We performed resting-state fMRI scans on 20 first-episode drug-naive MDD patients at baseline and after escitalopram medication for 8 weeks. Twenty healthy controls also received MRI scans with an 8-week interval...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844431/accounting-for-group-differences-in-study-retention-in-a-randomized-trial-of-specialized-treatment-for-first-episode-psychosis
#15
Kyaw Sint, Robert Rosenheck, Delbert G Robinson, Nina R Schooler, Patricia Marcy, John M Kane, Kim T Mueser, Haiqun Lin
BACKGROUND: Schizophrenia is a chronic disabling disorder for which current treatments are only partially effective. While the evaluation of novel interventions is a high priority, loss to follow-up is a major threat to validity. METHODS: Pattern mixture modeling is a statistical technique that incorporates information on patterns of retention that may bias comparisons between randomized treatment groups. This study used pattern mixture mixed model (PMMM) in the analysis of outcomes of a two-year cluster-randomized trial, the Recovery after an Initial Schizophrenia Episode-Early Treatment Program, which compared a coordinated specialty care intervention called NAVIGATE to usual community care (CC)...
August 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28843080/association-between-hypovitaminosis-d-and-cognitive-inhibition-impairment-during-major-depression-episode
#16
R Belzeaux, C Annweiler, J A Bertrand, O Beauchet, S Pichet, F Jollant, G Turecki, S Richard-Devantoy
BACKGROUND: Major depressive episode (MDE) has been associated with cognitive functioning alteration and hypovitaminosis D (hypoVD), but the relationship between hypoVD, depression, and cognition is not well understood. We aimed to compare patient with MDE with or without hypoVD in regard of cognitive functioning. METHODS: 91 patients (38.5 years old, 65.9% female) with MDE were included in a cross-sectional study and were evaluated with a complete cognitive battery...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28832750/effectiveness-evaluation-of-mood-disorder-treatment-algorithms-in-brazilian-public-healthcare-patients
#17
Ana F Lima, Sandro R Miguel, Mírian Cohen, Jacques J Zimmermann, Flávio M Shansis, Luciane N Cruz, Patrícia K Ziegelmann, Carisi A Polanczyk, Marcelo P Fleck
Objective: To assess the effectiveness of three mood disorder treatment algorithms in a sample of patients seeking care in the Brazilian public healthcare system. Methods: A randomized pragmatic trial was conducted with an algorithm developed for treating episodes of major depressive disorder (MDD), bipolar depressive episodes and mixed episodes of bipolar disorder (BD). Results: The sample consisted of 259 subjects diagnosed with BD or MDD (DSM-IV-TR)...
August 21, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28831260/an-observational-study-of-duloxetine-versus-ssri-monotherapy-in-japanese-patients-with-major-depressive-disorder-subgroup-analyses-of-treatment-effectiveness-for-pain-depressive-symptoms-and-quality-of-life
#18
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: To examine how clinical and demographic patient baseline characteristics influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) treatment, in real-world Japanese clinical settings of patients with major depressive disorder (MDD) and associated painful physical symptoms (PPS). METHODS: This was a multicenter, 12-week, prospective, observational study in patients with MDD (Quick Inventory of Depressive Symptomatology ≥16) and at least moderate PPS (Brief Pain Inventory-Short Form [BPI-SF] average pain ≥3)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28814728/prevalence-of-smoking-in-patients-with-bipolar-disorder-major-depressive-disorder-and-schizophrenia-and-their-relationships-with-quality-of-life
#19
Xiao-Hong Li, Feng-Rong An, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Ping-Ping Wu, Xin Jin, Yu-Tao Xiang
Few studies have compared the prevalence of smoking between patients with bipolar disorder, major depressive disorder (MDD) and schizophrenia. This study examined the prevalence of smoking and its relationships with demographic and clinical characteristics, and quality of life (QOL) in patients with these psychiatric disorders. A total of 1,102 inpatients were consecutively screened. Psychopathology and QOL were measured with standardized instruments. The prevalence of current smoking in the whole sample was 16...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#20
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
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