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First Major Depressive Episode

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https://www.readbyqxmd.com/read/29429423/aberrant-topographical-organization-in-default-mode-network-in-first-episode-remitted-geriatric-depression-a-graph-theoretical-analysis
#1
Yan Zhu, Dongqing Wang, Zhe Liu, Yuefeng Li
BACKGROUND: Neuroimaging studies have shown that major depressive disorder is associated with altered activity patterns of the default-mode network (DMN). In this study, we sought to investigate the topological organization of the DMN in patients with remitted geriatric depression (RGD) and whether RGD patients would be more likely to show disrupted topological configuration of the DMN during the resting-state. METHODS: Thirty-three RGD patients and thirty-one healthy control participants underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans...
February 12, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29424401/-association-between-adverse-childhood-experiences-with-depression-in-adults-consulting-in-primary-care
#2
Verónica Vitriol, Alfredo Cancino, Marcelo Leiva-Bianchi, Carlos Serrano, Soledad Ballesteros, Soledad Potthoff, Cristián Cáceres, Marcela Ormazábal, Andrea Asenjo
BACKGROUND: Traumatic experiences during childhood may influence the development of mental disorders during adulthood. AIM: To determine clinical and psychosocial variables that are associated with a higher frequency of adverse childhood experiences (ACE) in patients who consult for depression in Primary Health Care clinics in Chile. MATERIAL AND METHODS: A socio-demographic interview, the mini international neuropsychiatric interview (MINI), a screening for ACE, a questionnaire for partner violence (PV), the Life Experiences Survey (LES) and the Hamilton Rating Scale for Depression (HRDS) were applied to 394 patients with major depression (87% women)...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29421266/neural-correlates-of-working-memory-in-first-episode-and-recurrent-depression-an-fmri-study
#3
Dilara Yüksel, Bruno Dietsche, Carsten Konrad, Udo Dannlowski, Tilo Kircher, Axel Krug
BACKGROUND: Patients suffering from major depressive disorder (MDD) show deficits in working memory (WM) performance accompanied by bilateral fronto-parietal signal changes. It is unclear whether patients with a first depressive episode (FDE) exhibit the same BOLD signal changes as patients with recurrent depressive episodes (RDE). METHODS: We investigated seventy-four MDD inpatients (48 RDE, 26 FDE) and 74 healthy control (HC) subjects performing an n-back WM task (0-back, 2-back, 3-back condition) in a 3T-fMRI...
February 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29397669/korean-medication-algorithm-for-depressive-disorders-2017-third-revision
#4
Jeong Seok Seo, Won-Myong Bahk, Hee Ryung Wang, Young Sup Woo, Young-Min Park, Jong-Hyun Jeong, Won Kim, Se-Hoon Shim, Jung Goo Lee, Duk-In Jon, Kyung Joon Min
Objective: In 2002, the Korean Society for Affective Disorders developed the guidelines for the treatment of major depressive disorder (MDD), and revised it in 2006 and 2012. The third revision of these guidelines was undertaken to reflect advances in the field. Methods: Using a 44-item questionnaire, an expert consensus was obtained on pharmacological treatment strategies for MDD 1) without or 2) with psychotic features, 3) depression subtypes, 4) maintenance, 5) special populations, 6) the choice of an antidepressant (AD) regarding safety and adverse effects, and 7) non-pharmacological biological therapies...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29397079/electroencephalography-source-functional-connectivity-reveals-abnormal-high-frequency-communication-among-large-scale-functional-networks-in-depression
#5
Alexis E Whitton, Stephanie Deccy, Manon L Ironside, Poornima Kumar, Miranda Beltzer, Diego A Pizzagalli
BACKGROUND: Functional magnetic resonance imaging studies of resting-state functional connectivity have shown that major depressive disorder (MDD) is characterized by increased connectivity within the default mode network (DMN) and between the DMN and the frontoparietal network (FPN). However, much remains unknown about abnormalities in higher frequency (>1 Hz) synchronization. Findings of abnormal synchronization in specific frequencies would contribute to a better understanding of the potential neurophysiological origins of disrupted functional connectivity in MDD...
January 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29373616/differences-in-the-cognitive-profile-of-depression-between-racial-groups
#6
Jon E Grant, Michael Harries, Samuel R Chamberlain
BACKGROUND: There is little research concerning whether race is associated with different clinical presentations of psychiatric disorders. Understanding the racial aspects of cognitive differences among depressed adults could help identify specific targets for depression treatment. METHODS: We recruited 59 participants (52.5% white, 47.5% African American), age 18 to 60, with a current diagnosis of major depressive disorder (MDD). All participants underwent a cognitive battery that included tasks assessing decision-making, response inhibition, working memory, and executive planning...
February 2018: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29368955/translating-cognitive-vulnerability-theory-into-improved-adolescent-depression-screening-a-receiver-operating-characteristic-approach
#7
Joseph R Cohen, Felix K So, Benjamin L Hankin, Jami F Young
Traditionally, screening research tests how well a given symptom inventory can identify a concurrent depressive episode. Although developmental psychopathology could inform screening protocols for a myriad of depression outcomes (e.g., prospective depressive episodes), approaches typically used in research make it difficult to translate these findings. Using a translational analytic approach and multiwave longitudinal study design, we examined how screening for cognitive vulnerabilities (rumination, dysfunctional attitudes, and attributional style) may improve our ability to identify concurrent depressive episodes, prospective depressive episodes, first lifetime episodes of depression, and recurrent major depressive episodes...
January 25, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29368028/work-disability-trajectories-among-individuals-with-a-sick-leave-spell-due-to-depressive-episode%C3%A2-%C3%A2-%C3%A2-21-days-a-prospective-cohort-study-with-13-month-follow-up
#8
Kristin Farrants, Emilie Friberg, Sara Sjölund, Kristina Alexanderson
Background Despite the increasing pattern of sick leave associated with depression in western countries, little is known about future work disability patterns among such sickness absentees. Aim To identify work disability (sick leave and disability pension) trajectories after the 21st day of a sick-leave spell due to depressive episode, and to investigate sociodemographic and morbidity characteristics of individuals in different trajectory groups. Methods This is a prospective cohort study using Swedish nationwide register data...
January 24, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29352386/glucose-homeostasis-in-major-depression-and-schizophrenia-a-comparison-among-drug-na%C3%A3-ve-first-episode-patients
#9
Johann Steiner, Brisa S Fernandes, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Sabine Westphal, Katrin Borucki, Kolja Schiltz, Zoltán Sarnyai, Hans-Gert Bernstein
There is evidence for insulin resistance in drug-naïve first-episode schizophrenia (Sz) patients. We have tested whether impaired insulin homeostasis is also present in first-episode patients with major depression (MD) and if this can be discerned from stress-related and medication effects. Homeostatic model assessment of insulin resistance (HOMA-IR) was determined in a cross-sectional cohort study of acute first-episode drug-naïve patients with MD (n = 18) or Sz (n = 24), and healthy controls (C, n = 43)...
January 19, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29334645/co-morbid-depressive-disorder-is-associated-with-better-neurocognitive-performance-in-first-episode-schizophrenia-spectrum
#10
Sarah E Herniman, Sue M Cotton, Eóin Killackey, Robert Hester, Kelly A Allott
BACKGROUND: Both major depressive disorder (MDD) and first episode schizophrenia spectrum (FES) are associated with significant neurocognitive deficits. However, it remains unclear whether the neurocognitive deficits in individuals with FES are more severe if there is comorbid depressive disorder. The aim of this study was to compare the neurocognitive profiles between those with and without full-threshold depressive disorder in FES. METHOD: This study involved secondary analysis of baseline data from a randomized controlled trial of vocational intervention for young people with first-episode psychosis (N = 82; age range: 15-25 years)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331696/does-early-response-predict-subsequent-remission-in-bipolar-depression-treated-with-repeated-sleep-deprivation-combined-with-light-therapy-and-lithium
#11
Masahiro Suzuki, Sara Dallaspezia, Clara Locatelli, Makoto Uchiyama, Cristina Colombo, Francesco Benedetti
BACKGROUND: The combination of three cycles of sleep deprivation (SD), light therapy (LT), and lithium has recently been proposed as a possible first-line treatment for bipolar depression. However, it is unclear whether early improvement predicts final response/remission in bipolar depression treated with this regimen. METHOD: We studied 220 consecutively admitted inpatients with a major depressive episode in the course of bipolar disorder. The relation between response to first SD and response/remission at the end of the treatment (day 6) was analyzed using logistic regression analysis...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331152/functioning-before-and-after-a-major-depressive-episode-pre-existing-vulnerability-or-scar-a-prospective-three-wave-population-based-study
#12
E H Bos, M Ten Have, S van Dorsselaer, B F Jeronimus, R de Graaf, P de Jonge
BACKGROUND: The vulnerability hypothesis suggests that impairments after remission of depressive episodes reflect a pre-existing vulnerability, while the scar hypothesis proposes that depression leaves residual impairments that confer risk of subsequent episodes. We prospectively examined vulnerability and scar effects in mental and physical functioning in a representative Dutch population sample. METHODS: Three waves were used from the Netherlands Mental Health Survey and Incidence Study-2, a population-based study with a 6-years follow-up...
January 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29316519/the-regional-homogeneity-of-cingulate-precuneus-regions-the-putative-biomarker-for-depression-and-anxiety
#13
Chien-Han Lai
OBJECTIVES: In addition to clinical interview, the modern putative biomarker to differentiate depression and anxiety would be warranted. The translational medicine characteristics of neuroimaging, such as the regional homogeneity (ReHo), is an option for depression and anxiety. Therefore we designed this study trying to identify the biomarker pattern for depression and anxiety. METHODS: Resting-state functional magnetic resonance imaging was acquired for 53 patients with first-episode medicine-naïve major depressive disorder (MDD), 53 first-episode medicine-naïve patients with panic disorder (PD) and 54 controls...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29310066/is-recurrence-in-major-depressive-disorder-related-to-bipolarity-and-mixed-features-results-from-the-bridge-ii-mix-study
#14
Lorenzo Mazzarini, Georgios D Kotzalidis, Daria Piacentino, Salvatore Rizzato, Jules Angst, Jean-Michel Azorin, Charles L Bowden, Sergey Mosolov, Allan H Young, Eduard Vieta, Paolo Girardi, Giulio Perugi
BACKGROUND: Current classifications separate Bipolar (BD) from Major Depressive Disorder (MDD) based on polarity rather than recurrence. We aimed to determine bipolar/mixed feature frequency in a large MDD multinational sample with (High-Rec) and without (Low-Rec) >3 recurrences, comparing the two subsamples. METHODS: We measured frequency of bipolarity/hypomanic features during current depressive episodes (MDEs) in 2347 MDD patients from the BRIDGE-II-mix database, comparing High-Rec with Low-Rec...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29305876/resting-frontal-eeg-asymmetry-patterns-in-adolescents-with-and-without-major-depression
#15
Barbara D Grünewald, Ellen Greimel, Monika Trinkl, Jürgen Bartling, Nicola Großheinrich, Gerd Schulte-Körne
More right-sided frontal brain resting activity has been postulated to be a correlate of major depression in adults. In children and adolescents, more right-sided activity (as indicated by more left-sided alpha activity) seems to be associated with psychosocial risk factors. However, an association of frontal asymmetry and manifest unipolar depression has not been shown in adolescents so far. We analyzed frontal asymmetry in 20 adolescents (12-17 years) with unipolar depression (12 with first episode, 8 with recurrent depression) and 31 healthy age-matched controls...
January 3, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29287766/serotonin-transporter-gene-expression-predicts-the-worsening-of-suicidal-ideation-and-suicide-attempts-along-a-long-term-follow-up-of-a-major-depressive-episode
#16
Julia-Lou Consoloni, El Chérif Ibrahim, Marie-Noëlle Lefebvre, Xavier Zendjidjian, Emilie Olié, Pascale Mazzola-Pomietto, Thomas Desmidt, Ludovic Samalin, Pierre-Michel Llorca, Mocrane Abbar, Jorge Lopez-Castroman, Emmanuel Haffen, Karine Baumstarck, Jean Naudin, Jean-Michel Azorin, Wissam El-Hage, Philippe Courtet, Raoul Belzeaux
The quest for biomarkers in suicidal behaviors has been elusive so far, despite their potential utility in clinical practice. One of the most robust biological findings in suicidal behaviors is the alteration of the serotonin transporter function in suicidal individuals. Our main objective was to investigate the predictive value of the serotonin transporter gene expression (SLC6A4) for suicidal ideation and as secondary, for suicide attempts in individuals with a major depressive episode (MDE). A 30-week prospective study was conducted on 148 patients with a MDE and 100 healthy controls including 4 evaluation times (0, 2, 8 and 30 weeks)...
December 26, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29284510/the-napressim-trial-the-use-of-low-dose-prophylactic-naloxone-infusion-to-prevent-respiratory-depression-with-intrathecally-administered-morphine-in-elective-hepatobiliary-surgery-a-study-protocol-and-statistical-analysis-plan-for-a-randomised-controlled-trial
#17
David Cosgrave, Marie Galligan, Era Soukhin, Victoria McMullan, Siobhan McGuinness, Anand Puttappa, Niamh Conlon, John Boylan, Rabia Hussain, Peter Doran, Alistair Nichol
BACKGROUND: Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dose, prophylactic naloxone infusion following intrathecally administered morphine may significantly reduce postoperative respiratory depression. The NAPRESSIM trial aims to answer this question...
December 29, 2017: Trials
https://www.readbyqxmd.com/read/29275591/-dysfunctional-resting-state-connectivity-of-default-mode-network-in-adolescent-patients-with-first-episode-drug-naive-major-depressive-disorder
#18
S Y Li, Y Zhu, Y L Wang, P P Lü, W B Zuo, F Y Li
Objective: To study resting-state functional connectivity (FC) of default mode network (DMN) in adolescent patients with first-episode drug-naive major depressive disorder (MDD). Methods: We enrolled thirty first-episode and drug-naive adolescent MDD patients and twenty-nine adolescent healthy control (HC) participants in the First Affiliated Hospital of Zhengzhou University. There were no differences in age, sex, and education between the MDD and HC group. Resting-state functional magnetic resonance images (fMRI) was performed...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29241358/criticisms-of-kraepelin-s-psychiatric-nosology-1896-1927
#19
Kenneth S Kendler, Eric J Engstrom
Emil Kraepelin's psychiatric nosology, proposed in the 5th and 6th editions of his textbook published in 1896 and 1899, did not quickly gain worldwide acceptance, but was instead met with substantial and sustained criticism. The authors review critiques of Kraepelin's work published in his lifetime by Adolf Meyer, Friedrich Jolly, Eugenio Tanzi, Alfred Hoche, Karl Jaspers, and Willy Hellpach. These critics made six major points. First, Kraepelin's new categories of dementia praecox and manic-depressive insanity were too broad and too heterogeneous...
December 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29240527/depressive-symptom-prevalence-and-predictors-in-the-first-half-of-pregnancy
#20
Patricia Anne Kinser, Leroy R Thacker, Dana Lapato, Sara Wagner, Roxann Roberson-Nay, Lisa Jobe-Shields, Ananda Amstadter, Timothy P York
INTRODUCTION: Major depression during the peripartum (MDP) period carries significant public health impact due to the potential adverse effects on maternal, infant, and family outcomes. METHODS: As part of a larger longitudinal study, this cross-sectional observational study sought to build upon the current literature on the prevalence and predictors of depression in the early second trimester of pregnancy, as related to generally accepted risk factors and other less explored risk factors...
December 14, 2017: Journal of Women's Health
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