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First Major Depressive Episode

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https://www.readbyqxmd.com/read/28437669/white-matter-microstructural-abnormalities-and-their-association-with-anticipatory-anhedonia-in-depression
#1
Xin-Hua Yang, Yi Wang, Dong-Fang Wang, Kai Tian, Eric F C Cheung, Guang-Rong Xie, Raymond C K Chan
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients...
April 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28421012/moderated-online-social-therapy-a-model-for-reducing-stress-in-carers-of-young-people-diagnosed-with-mental-health-disorders
#2
John Gleeson, Reeva Lederman, Peter Koval, Greg Wadley, Sarah Bendall, Sue Cotton, Helen Herrman, Kingsley Crisp, Mario Alvarez-Jimenez
Family members caring for a young person diagnosed with the onset of mental health problems face heightened stress, depression, and social isolation. Despite evidence for the effectiveness of family based interventions, sustaining access to specialist family interventions is a major challenge. The availability of the Internet provides possibilities to expand and sustain access to evidence-based psychoeducation and personal support for family members. In this paper we describe the therapeutic model and the components of our purpose-built moderated online social therapy (MOST) program for families...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28411506/the-ten-year-course-of-depression-in-primary-care-and-long-term-effects-of-psychoeducation-psychiatric-consultation-and-cognitive-behavioral-therapy
#3
Henk Jan Conradi, Elisabeth H Bos, Jan H Kamphuis, Peter de Jonge
BACKGROUND: While the majority of depressed patients are treated in primary care, long-term follow-up data on the naturalistic course of depression and treatment effectiveness in this setting are scarce. This study examined the ten-year course of depression in primary care patients who had participated in a randomized clinical trial aiming at enhancement of depression outcomes. METHODS: Of the original sample (n=267), 166 patients participated in the ten-year follow-up; missingness was random...
March 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28407556/functional-network-based-statistics-in-depression-theory-of-mind-subnetwork-and-importance-of-parietal-region
#4
Chien-Han Lai, Yu-Te Wu, Yuh-Ming Hou
OBJECTIVE: The functional network analysis of whole brain is an emerging field for research in depression. We initiated this study to investigate which subnetwork is significantly altered within the functional connectome in major depressive disorder (MDD). METHODS: The study enrolled 52 first-episode medication-naïve patients with MDD and 40 controls for functional network analysis. All participants received the resting-state functional imaging using a 3-Tesla magnetic resonance scanner...
April 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28394509/adverse-childhood-experiences-and-risk-for-first-episode-major-depression-during-the-menopause-transition
#5
C Neill Epperson, Mary D Sammel, Tracy L Bale, Deborah R Kim, Sarah Conlin, Stephanie Scalice, Katharine Freeman, Ellen W Freeman
OBJECTIVE: Stress exposures may have a differential impact on risk and resilience for depression depending on their timing across development. We sought to determine whether adverse childhood experiences (ACEs) and their onset with respect to puberty contribute to the increased risk observed in first-episode major depressive disorder (MDD) during the menopause transition. METHODS: Participants were from the Penn Ovarian Aging Study cohort, which is composed of women from Philadelphia County, Pennsylvania, who underwent behavioral, cognitive, and endocrine evaluations approximately yearly from 1996 to 2012 and completed the Adverse Childhood Experiences Questionnaire at study end point (n = 243)...
March 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#6
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28384269/amplitude-of-low-frequency-fluctuations-in-first-episode-drug-na%C3%A3-ve-depressive-patients-a-5-year-retrospective-study
#7
Kerang Zhang, Zhifen Liu, Xiaohua Cao, Chunxia Yang, Yong Xu, Ting Xu, Cheng Xu, Zhi Yang
Despite different treatments and courses of illness, depressive symptoms appear similar in bipolar disorder (BD) and major depressive disorder (MDD), causing BD with an onset of depressive episode being frequently misdiagnosed as MDD, and leading to inappropriate treatment and poor clinical outcomes. Therefore, there is an urgent need to explore underlying neural basis to distinguish BD from MDD. The medical records of 80 first-episode, drug-naïve depressive patients with an initial diagnosis of MDD and illness duration of at least 5 years were reviewed retrospectively for this study...
2017: PloS One
https://www.readbyqxmd.com/read/28373802/is-the-ultimate-treatment-response-predictable-with-early-response-in-major-depressive-episode
#8
Aslı Çiftçi, Halis Ulaş, Ahmet Topuzoğlu, Zeliha Tunca
INTRODUCTION: New evidence suggests that the efficacy of antidepressants occurs within the first weeks of treatment and this early response predicts the later response. The purpose of the present study was to investigate if the partial response in the first week predicts the response at the end of treatment in patients with major depressive disorder who are treated with either antidepressant medication or electroconvulsive therapy. METHODS: Inpatients from Dokuz Eylül University Hospital with a major depressive episode, treated with antidepressant medication (n=52) or electroconvulsive therapy (ECT) (n=48), were recruited for the study...
September 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28371529/socioeconomic-predictors-of-incident-depression-in-systemic-lupus-erythematosus
#9
Natalie McCormick, Laura Trupin, Edward H Yelin, Patricia P Katz
Objective To assess different measures of socioeconomic status (SES) as predictors of incident depression among women with systemic lupus erythematosus (SLE). Methods Data derive from the 2010-2015 waves of the Lupus Outcomes Study, where individuals with confirmed SLE were interviewed annually by telephone. Depression was assessed with the Center for Epidemiological Studies Depression Scale (CES-D), using a validated lupus-specific cutoff (≥23) for major depressive disorder. Women interviewed in ≥2 consecutive waves, with scores <23 in the first wave (T1), were included...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#10
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28361870/associations-between-daily-affective-instability-and-connectomics-in-functional-subnetworks-in-remitted-patients-with-recurrent-major-depressive-disorder
#11
Michelle N Servaas, Harriëtte Riese, Remco J Renken, Marieke Wichers, Jojanneke A Bastiaansen, Caroline A Figueroa, Hanneke Geugies, Roel Jt Mocking, Linda Geerligs, Jan-BernardC Marsman, André Aleman, Aart H Schene, Robert A Schoevers, Henricus G Ruhé
Remitted patients with major depressive disorder (rMDD) often report more fluctuations in mood as residual symptomatology. It is unclear how this affective instability is associated with information processing related to the default mode (DMS), salience/reward (SRS) and fronto-parietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD). Sixty-two unipolar, drug-free rrMDD patients (⩾2 MDD-episodes) and 41 HC (HC) were recruited. We used Experience Sampling Methodology (ESM) to monitor mood/cognitions (10 times a day for 6 days) and calculated affective instability using the mean adjusted absolute successive difference...
March 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28359201/a-5-year-observational-study-of-patients-with-treatment-resistant-depression-treated-with-vagus-nerve-stimulation-or-treatment-as-usual-comparison-of-response-remission-and-suicidality
#12
Scott T Aaronson, Peter Sears, Francis Ruvuna, Mark Bunker, Charles R Conway, Darin D Dougherty, Frederick W Reimherr, Thomas L Schwartz, John M Zajecka
OBJECTIVE: The Treatment-Resistant Depression Registry investigated whether adjunctive vagus nerve stimulation (VNS) with treatment as usual in depression has superior long-term outcomes compared with treatment as usual only. METHOD: This 5-year, prospective, open-label, nonrandomized, observational registry study was conducted at 61 U.S. sites and included 795 patients who were experiencing a major depressive episode (unipolar or bipolar depression) of at least 2 years' duration or had three or more depressive episodes (including the current episode), and who had failed four or more depression treatments (including ECT)...
March 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28355042/contributing-factors-and-mental-health-outcomes-of-first-suicide-attempt-during-childhood-and-adolescence-results-from-a-nationally-representative-study
#13
Hugo Peyre, Nicolas Hoertel, Coline Stordeur, Gaële Lebeau, Carlos Blanco, Kibby McMahon, Romain Basmaci, Cédric Lemogne, Frédéric Limosin, Richard Delorme
OBJECTIVE: To investigate whether risk factors for suicide attempts differ in children and adolescents and to categorize adulthood mental health outcomes of child and adolescent suicide attempters in the general population. METHODS: Using a large (N = 34,653), nationally representative US adult sample, the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions, we examined whether individuals who first attempted suicide during childhood (under the age of 13 years) differ from those who first attempted suicide during adolescence (13 through 17 years) in (1) contributing factors for first suicide attempt, including mental disorders and traumatic experiences that occurred before the first suicide attempt, parental history of mental disorders, and family poverty and (2) adulthood mental health outcomes, including lifetime and current prevalence of DSM-IV psychiatric disorders and quality of life measures...
March 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28351403/childhood-neglect-predicts-the-course-of-major-depression-in-a-tertiary-care-sample-a-follow-up-study
#14
Sabrina Paterniti, Irit Sterner, Christine Caldwell, Jean-Claude Bisserbe
BACKGROUND: The course of depression is poorer in clinical settings than in the general population. Several predictors have been studied and there is growing evidence that a history of childhood maltreatment consistently predicts a poorer course of depression. METHODS: Between 2008 and 2012, we assessed 238 individuals suffering from a current episode of major depression. Fifty percent of these (N = 119) participated in a follow-up study conducted between 2012 and 2014 that assessed sociodemographic and clinical variables, the history of childhood abuse and neglect (using the Adverse Childhood Experience questionnaire), and the course of depression between baseline and follow-up interview (using the Life Chart method)...
March 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28338340/serum-interleukin-6-is-related-to-lower-cognitive-functioning-in-elderly-patients-with-major-depression
#15
Nehad Samir Ali, Abdel Hamid Hashem Hashem, Akmal Mostafa Hassan, Alia Adel Saleh, Heba Nabil El-Baz
BACKGROUND: There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD). OBJECTIVES: (1) Assessment of serum IL-6 levels and cognitive functions in elderly patients suffering from major depression and comparing them to healthy age-matched control subjects; (2) correlation between serum IL-6 levels and clinical characteristics of depression and cognitive functions in these patients...
March 24, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28336497/intrinsic-disruption-of-white-matter-microarchitecture-in-first-episode-drug-naive-major-depressive-disorder-a-voxel-based-meta-analysis-of-diffusion-tensor-imaging
#16
REVIEW
Guangxiang Chen, Yi Guo, Hongyan Zhu, Weihong Kuang, Feng Bi, Hua Ai, Zhongwei Gu, Xiaoqi Huang, Su Lui, Qiyong Gong
Previous studies have demonstrated the influences of episodes and antidepressant drugs on white matter (WM) in patients with major depressive disorder (MDD). However, most diffusion tensor imaging (DTI) studies included highly heterogeneous individuals with different numbers of depressive episodes or medication status. To exclude the confounding effects of multiple episodes or medication, we conducted a quantitative voxel-based meta-analysis of fractional anisotropy (FA) in patients with first-episode, drug-naive MDD to identify the intrinsic WM alterations involved in the pathogenesis of MDD...
March 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28333931/differential-gene-expression-in-patients-with-subsyndromal-symptomatic-depression-and-major-depressive-disorder
#17
Chengqing Yang, Guoqin Hu, Zezhi Li, Qingzhong Wang, Xuemei Wang, Chengmei Yuan, Zuowei Wang, Wu Hong, Weihong Lu, Lan Cao, Jun Chen, Yong Wang, Shunying Yu, Yimin Zhou, Zhenghui Yi, Yiru Fang
BACKGROUND: Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders. Nowadays, the differential gene expression between MDD and SSD is still unknown. In our previous study, we compared the expression profile and made the classification with the leukocytes by using whole-genome cRNA microarrays among drug-free first-episode subjects with SSD, MDD and matched healthy controls (8 subjects in each group), and finally determined 48 gene expression signatures...
2017: PloS One
https://www.readbyqxmd.com/read/28298187/icanadapt-early-protocol-randomised-controlled-trial-rct-of-clinician-supervised-transdiagnostic-internet-delivered-cognitive-behaviour-therapy-icbt-for-depression-and-or-anxiety-in-early-stage-cancer-survivors-vs-treatment-as-usual
#18
M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith, G Andrews
BACKGROUND: This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/DESIGN: Early stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28287187/similarities-and-differences-of-functional-connectivity-in-drug-na%C3%A3-ve-first-episode-adolescent-and-young-adult-with-major-depressive-disorder-and-schizophrenia
#19
Shengnan Wei, Fay Womer, Haiyang Geng, Xiaowei Jiang, Qian Zhou, Miao Chang, Yifang Zhou, Yanqing Tang, Fei Wang
Major depressive disorder (MDD) and schizophrenia (SZ) are considered two distinct psychiatric disorders. Yet, they have considerable overlap in symptomatology and clinical features, particularly in the initial phases of illness. The amygdala and prefrontal cortex (PFC) appear to have critical roles in these disorders; however, abnormalities appear to manifest differently. In our study forty-nine drug-naïve, first-episode MDD, 45 drug-naïve, first-episode SZ, and 50 healthy control (HC) participants from 13 to 30 years old underwent resting-state functional magnetic resonance imaging...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277876/the-use-of-adjunctive-antipsychotics-to-treat-depression-in-uk-primary-care
#20
F X Lamy, D Saragoussi, M E Johnson, A Guiraud-Diawara, K T Jørgensen, J Y Loze, A Maguire
OBJECTIVE: Adjunctive antipsychotic therapy can be prescribed to patients with depression who have inadequate response to antidepressants. This study aimed to describe the use of adjunctive antipsychotics over a time period that includes the authorization in 2010 of prolonged-release quetiapine as the first adjunct antipsychotic to be used in major depressive disorder in the UK. RESEARCH DESIGN AND METHODS: Adults with an episode of depression between January 1, 2005 and July 31, 2013 were identified from antidepressant prescriptions and depression diagnoses in the UK Clinical Practice Research Datalink...
May 2017: Current Medical Research and Opinion
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