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First Major Depressive Episode

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https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#1
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
April 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28484349/one-year-follow-up-of-patients-with-a-diagnosis-of-first-episode-psychosis
#2
Atena Enderami, Fatemeh Sheikh Monesi, Mehran Zarghami
INTRODUCTION: Early diagnosis of symptoms related to psychotic disorders causes hyper responsiveness, recurrence reduction and quality of life improvement. The aim of this study was one-year follow-up of the clinical course and outcomes of hospitalized patients with first episode psychotic disorders and detection of factors affecting consequences. METHODS: This longitudinal descriptive study was conducted during 2012 to 2013 on hospitalized patients at Zare Hospital in Sari, Iran, with any psychotic symptoms and with diagnosis of first episode psychosis...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28472556/factors-associated-with-greater-severity-of-depression-in-chilean-primary-care-patients
#3
Verónica Vitriol, Alfredo Cancino, Soledad Ballesteros, Soledad Potthoff, Carlos Serrano
Objective: To determine clinical and psychosocial variables associated with increased depression severity in patients who consult public primary health care clinics (PHCs) in Chile. Methods: The study included 394 patients diagnosed with major depressive disorder (MDD) according to ICD-10 criteria who were evaluated between February and September 2014 using a sociodemographic interview, the Mini-International Neuropsychiatric Interview (MINI), a screening for childhood trauma, a scale for partner violence, the Life Events Survey (LES), and the Hamilton Rating Scale for Depression (HRSD)...
May 4, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28469817/no-relationship-between-baseline-salivary-alpha-amylase-and-state-trait-anxiety-inventory-score-in-drug-na%C3%A3-ve-patients-with-short-illness-duration-first-episode-major-depressive-disorder-an-exploratory-study
#4
Joanna Szarmach, Wiesław-Jerzy Cubała, Jerzy Landowski, Anna Chrzanowska
BACKGROUND: Salivary α-amylase (sAA) activity alternations are observed in major depressive disorder (MDD) being associated with depression severity and its specific psychopathological dimensions with anxiety being attributed to distress. No data is available on sAA in MDD according to Hamilton Rating Scale for Depression (HAMD-17) and State-Trait Anxiety Inventory (STAI). The exploratory study examines whether and to what extent baseline sAA level is interrelated to the psychopathological features including severity of symptoms and specific psychopathological dimensions...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28463749/right-fronto-temporal-activation-differs-between-chinese-first-episode-and-recurrent-major-depression-disorders-during-a-verbal-fluency-task-a-near-infrared-spectroscopy-study
#5
Jiuju Wang, Bin Lv, Wenxiang Quan, Taeko N Wydell, Ju Tian, Pengfei Wang, Jin Liu, Wentian Dong
No abstract text is available yet for this article.
March 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28462772/mixed-features-in-major-depressive-disorder-diagnoses-and-treatments
#6
Trisha Suppes, Michael Ostacher
For the first time in 20 years, the American Psychiatric Association (APA) updated the psychiatric diagnostic system for mood disorders in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Perhaps one of the most notable changes in the DSM-5 was the recognition of the possibility of mixed symptoms in major depression and related disorders (MDD). While MDD and bipolar and related disorders are now represented by 2 distinct chapters, the addition of a mixed features specifier to MDD represents a structural bridge between bipolar and major depression disorders, and formally recognizes the possibility of a mix of hypomania and depressive symptoms in someone who has never experienced discrete episodes of hypomania or mania...
April 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28449649/a-case-of-recurrent-depressive-disorder-presenting-with-alice-in-wonderland-syndrome-psychopathology-and-pre-and-post-treatment-fdg-pet-findings
#7
Tatsushi Yokoyama, Tsuyoshi Okamura, Miwako Takahashi, Toshimitsu Momose, Shinsuke Kondo
BACKGROUND: Alice in Wonderland syndrome (AIWS) is a rare neuropsychiatric syndrome that typically manifests in distortion of extrapersonal visual image, altered perception of one's body image, and a disturbed sense of the passage of distance and time. Several conditions have been reported to contribute to AIWS, although its biological basis is still unknown. Here, we present the first case demonstrating a clear concurrence of recurrent depressive disorder and AIWS. The clinical manifestations and pre- and post-treatment fluorodeoxyglucose positron-emission tomographic (FDG-PET) images provide insights into the psychopathological and biological basis of AIWS...
April 27, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28441588/reduced-ena78-levels-as-novel-biomarker-for-major-depressive-disorder-and-venlafaxine-efficiency-result-from-a-prospective-longitudinal-study
#8
Zezhi Li, Zuowei Wang, Chen Zhang, Jun Chen, Yousong Su, Jia Huang, Zhenghui Yi, Chengmei Yuan, Wu Hong, Yong Wang, Zhiguo Wu, Yingyan Hu, Lan Cao, Daihui Peng, Yangtai Guan, Yimin Zou, Shunying Yu, Donghong Cui, Yiru Fang
Although lines of evidence demonstrated that cytokines play an important role in the pathogenesis of major depressive disorder (MDD), none of the them have been established as reliable biomarkers. We use our previous whole-genome cRNA microarray data to identify epithelial cell-derived neutrophil-activating peptide 78 (ENA78), the most differentially expressed cytokine in peripheral blood between MDD patients and healthy controls; and then we confirmed the result by the quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) for mRNA and protein level, respectively, in an independent drug-naïve first-episode sample set...
March 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28441583/randomized-controlled-trial-of-repetitive-transcranial-magnetic-stimulation-combined-with-paroxetine-for-the-treatment-of-patients-with-first-episode-major-depressive-disorder
#9
Yu-Mei Wang, Ning Li, Lin-Lin Yang, Mei Song, Le Shi, Wen-Hao Chen, Su-Xia Li, Xue-Yi Wang, Lin Lu
Repetitive transcranial magnetic stimulation (rTMS) has been introduced as a new and effective treatment option for major depression. This paper examined the effectiveness of rTMS on first episode depressed patients when combined with antidepressant drugs. A random sample of forty-three first-episode depressed patients received active or sham rTMS to the left dorsolateral prefrontal cortex, and concomitantly took paroxetine for 4 weeks, and paroxetine monotherapy for 4 weeks afterwards. Response was defined as a ≥50% decrease on the total Hamilton Depression Rating Scale (HDRS) from the baseline, and remission was defined as an HDRS total residual score <8...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28437669/white-matter-microstructural-abnormalities-and-their-association-with-anticipatory-anhedonia-in-depression
#10
Xin-Hua Yang, Yi Wang, Dong-Fang Wang, Kai Tian, Eric F C Cheung, Guang-Rong Xie, Raymond C K Chan
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients...
April 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28421012/moderated-online-social-therapy-a-model-for-reducing-stress-in-carers-of-young-people-diagnosed-with-mental-health-disorders
#11
John Gleeson, Reeva Lederman, Peter Koval, Greg Wadley, Sarah Bendall, Sue Cotton, Helen Herrman, Kingsley Crisp, Mario Alvarez-Jimenez
Family members caring for a young person diagnosed with the onset of mental health problems face heightened stress, depression, and social isolation. Despite evidence for the effectiveness of family based interventions, sustaining access to specialist family interventions is a major challenge. The availability of the Internet provides possibilities to expand and sustain access to evidence-based psychoeducation and personal support for family members. In this paper we describe the therapeutic model and the components of our purpose-built moderated online social therapy (MOST) program for families...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28411506/the-ten-year-course-of-depression-in-primary-care-and-long-term-effects-of-psychoeducation-psychiatric-consultation-and-cognitive-behavioral-therapy
#12
Henk Jan Conradi, Elisabeth H Bos, Jan H Kamphuis, Peter de Jonge
BACKGROUND: While the majority of depressed patients are treated in primary care, long-term follow-up data on the naturalistic course of depression and treatment effectiveness in this setting are scarce. This study examined the ten-year course of depression in primary care patients who had participated in a randomized clinical trial aiming at enhancement of depression outcomes. METHODS: Of the original sample (n=267), 166 patients participated in the ten-year follow-up; missingness was random...
March 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28407556/functional-network-based-statistics-in-depression-theory-of-mind-subnetwork-and-importance-of-parietal-region
#13
Chien-Han Lai, Yu-Te Wu, Yuh-Ming Hou
OBJECTIVE: The functional network analysis of whole brain is an emerging field for research in depression. We initiated this study to investigate which subnetwork is significantly altered within the functional connectome in major depressive disorder (MDD). METHODS: The study enrolled 52 first-episode medication-naïve patients with MDD and 40 controls for functional network analysis. All participants received the resting-state functional imaging using a 3-Tesla magnetic resonance scanner...
April 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28394509/adverse-childhood-experiences-and-risk-for-first-episode-major-depression-during-the-menopause-transition
#14
C Neill Epperson, Mary D Sammel, Tracy L Bale, Deborah R Kim, Sarah Conlin, Stephanie Scalice, Katharine Freeman, Ellen W Freeman
OBJECTIVE: Stress exposures may have a differential impact on risk and resilience for depression depending on their timing across development. We sought to determine whether adverse childhood experiences (ACEs) and their onset with respect to puberty contribute to the increased risk observed in first-episode major depressive disorder (MDD) during the menopause transition. METHODS: Participants were from the Penn Ovarian Aging Study cohort, which is composed of women from Philadelphia County, Pennsylvania, who underwent behavioral, cognitive, and endocrine evaluations approximately yearly from 1996 to 2012 and completed the Adverse Childhood Experiences Questionnaire at study end point (n = 243)...
March 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#15
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28384269/amplitude-of-low-frequency-fluctuations-in-first-episode-drug-na%C3%A3-ve-depressive-patients-a-5-year-retrospective-study
#16
Kerang Zhang, Zhifen Liu, Xiaohua Cao, Chunxia Yang, Yong Xu, Ting Xu, Cheng Xu, Zhi Yang
Despite different treatments and courses of illness, depressive symptoms appear similar in bipolar disorder (BD) and major depressive disorder (MDD), causing BD with an onset of depressive episode being frequently misdiagnosed as MDD, and leading to inappropriate treatment and poor clinical outcomes. Therefore, there is an urgent need to explore underlying neural basis to distinguish BD from MDD. The medical records of 80 first-episode, drug-naïve depressive patients with an initial diagnosis of MDD and illness duration of at least 5 years were reviewed retrospectively for this study...
2017: PloS One
https://www.readbyqxmd.com/read/28373802/is-the-ultimate-treatment-response-predictable-with-early-response-in-major-depressive-episode
#17
Aslı Çiftçi, Halis Ulaş, Ahmet Topuzoğlu, Zeliha Tunca
INTRODUCTION: New evidence suggests that the efficacy of antidepressants occurs within the first weeks of treatment and this early response predicts the later response. The purpose of the present study was to investigate if the partial response in the first week predicts the response at the end of treatment in patients with major depressive disorder who are treated with either antidepressant medication or electroconvulsive therapy. METHODS: Inpatients from Dokuz Eylül University Hospital with a major depressive episode, treated with antidepressant medication (n=52) or electroconvulsive therapy (ECT) (n=48), were recruited for the study...
September 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28371529/socioeconomic-predictors-of-incident-depression-in-systemic-lupus-erythematosus
#18
Natalie McCormick, Laura Trupin, Edward H Yelin, Patricia P Katz
Objective To assess different measures of socioeconomic status (SES) as predictors of incident depression among women with systemic lupus erythematosus (SLE). Methods Data derive from the 2010-2015 waves of the Lupus Outcomes Study, where individuals with confirmed SLE were interviewed annually by telephone. Depression was assessed with the Center for Epidemiological Studies Depression Scale (CES-D), using a validated lupus-specific cutoff (≥23) for major depressive disorder. Women interviewed in ≥2 consecutive waves, with scores <23 in the first wave (T1), were included...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#19
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28361870/associations-between-daily-affective-instability-and-connectomics-in-functional-subnetworks-in-remitted-patients-with-recurrent-major-depressive-disorder
#20
Michelle N Servaas, Harriëtte Riese, Remco J Renken, Marieke Wichers, Jojanneke A Bastiaansen, Caroline A Figueroa, Hanneke Geugies, Roel Jt Mocking, Linda Geerligs, Jan-BernardC Marsman, André Aleman, Aart H Schene, Robert A Schoevers, Henricus G Ruhé
Remitted patients with major depressive disorder (rMDD) often report more fluctuations in mood as residual symptomatology. It is unclear how this affective instability is associated with information processing related to the default mode (DMS), salience/reward (SRS) and fronto-parietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD). Sixty-two unipolar, drug-free rrMDD patients (⩾2 MDD-episodes) and 41 HC (HC) were recruited. We used Experience Sampling Methodology (ESM) to monitor mood/cognitions (10 times a day for 6 days) and calculated affective instability using the mean adjusted absolute successive difference...
March 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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