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First Major Depressive Episode

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https://www.readbyqxmd.com/read/29929113/predicting-suicidal-behaviour-after-first-episode-of-non-affective-psychosis-the-role-of-neurocognitive-functioning
#1
M Canal-Rivero, J D López-Moríñigo, E Setién-Suero, M Ruiz-Veguilla, J L Ayuso-Mateos, R Ayesa-Arriola, B Crespo-Facorro
BACKGROUND: Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period...
June 18, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29927960/occupational-exposure-factors-for-mental-and-behavioral-disorders-at-work-the-forec-thesaurus
#2
Alain Chamoux, Céline Lambert, Audrey Vilmant, Charlotte Lanhers, Raymond Agius, Mounir Boutaleb, Vincent Bonneterre, Geraldine Naughton, Bruno Pereira, Khalid Djeriri, Eric Ben-Brik, Christine Breton, Caroline De Clavière, Corinne Letheux, Anne-Gaëlle Paolillo, Madeleine Valenty, Odile Vandenberghe, Marie-Pierre Aeschlimann, Gérard Lasfargues, Francois-Xavier Lesage, Frédéric Dutheil
BACKGROUND: Mental disorders in the workplace are a major public health problem. Knowledge of the impact of the psychosocial work environment on mental and behavioral disorders can assist occupational physicians in the identification and description of occupational risk situations, and help to define priority actions. However, no classification for occupational exposure factors is currently available. We aimed to build a thesaurus of "Organizational, Relational, Ethical and other Contributing Factors" (FOREC) linked with the onset of mental and behavioral disorders...
2018: PloS One
https://www.readbyqxmd.com/read/29916219/serotonin-1a-receptor-density-measured-by-f18-mefway-pet-ct-in-mesiotemporal-cortex-and-raphe-does-not-discriminate-therapeutic-response-in-patients-with-major-depressive-episode
#3
Martin Barth, Andreas Dunzinger, Irina Wimmer, Johanna Winkler, Hans Rittmannsberger, Michael Nader, Robert Pichler
BACKGROUND: More than 50% of patients with major depressive episode (MDE) fail to respond to initial treatment with first line pharmacological therapy. Altered receptor and serotonin transporter function are considered to be associated with mental disorders. Our investigation aimed on the density of the HT1A receptor in mesiotemporal cortex (MTC) and raphe measured by F18-Mefway in patients with MDD. METHODS: Patients with untreated clinically suspected major depressive episode were recruited from June 2012 to May 2014...
June 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29912861/birth-month-and-course-of-recurrent-depressive-disorders-in-a-polish-population
#4
Monika Talarowska, Katarzyna Bliźniewska, Katarzyna Wargacka, Piotr Gałecki
BACKGROUND The aim of this study was to determine whether the specific season of the year during which the first trimester of pregnancy takes place is significantly associated with the course (intensification and frequency of occurrence) of an episode of recurrent depressive disorder in adult life. MATERIAL AND METHODS We enrolled 184 patients treated for recurrent depressive disorders. RESULTS An analysis of the results obtained indicates that the greatest number of people suffering from a major depressive episode were born in the spring and summer (from April to September), meaning that the first trimester of pregnancy occurred between October and March...
June 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29912848/identify-abnormalities-in-resting-state-brain-function-between-first-episode-drug-naive-major-depressive-disorder-and-remitted-individuals-a-3-year-retrospective-study
#5
Chunxia Yang, Aixia Zhang, Aixiang Jia, Jack X Ma, Ning Sun, Yanfang Wang, Xinrong Li, Zhifen Liu, Sha Liu, Yong Xu, Kerang Zhang
This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD...
June 15, 2018: Neuroreport
https://www.readbyqxmd.com/read/29896124/-immune-gate-of-psychopathology-the-role-of-gut-derived-immune-activation-in-major-psychiatric-disorders
#6
REVIEW
Leszek Rudzki, Agata Szulc
Interaction between the gastrointestinal tract (GI) and brain functions has recently become a topic of growing interest in psychiatric research. These multidirectional interactions take place in the so-called gut-brain axis or more precisely, the microbiota-gut-brain axis. The GI tract is the largest immune organ in the human body and is also the largest surface of contact with the external environment. Its functions and permeability are highly influenced by psychological stress, which are often a precipitating factor in the first episode, reoccurrence and/or deterioration of symptoms of psychiatric disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29890452/changes-in-heart-rate-variability-in-first-episode-drug-na%C3%A3-ve-adolescents-with-major-depressive-disorder-a-12-week-prospective-study
#7
Sang-Won Park, Jong-Ha Lee, Jihyun Kim, Sangil Suh, Moon-Soo Lee
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder, the onset of which frequently occurs during adolescence. While differences in heart rate variability (HRV) between depressed and healthy participants have previously been observed, results have been inconsistent. This study thus investigated the features of HRV in adolescents with MDD. METHODS: We recruited first-episode drug-naïve adolescents aged 13-18 years who had been diagnosed with MDD, and healthy age-matched controls...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29869403/circadian-rhythm-in-bipolar-disorder-a-review-of-the-literature
#8
REVIEW
Yoshikazu Takaesu
Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in patients with bipolar disorder (BD). Irregularity of the sleep-wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues have also been well-documented in BD. Circadian rhythm dysfunction is prominent in BD compared with that in major depressive disorders, implying that circadian rhythm dysfunction is a trait marker of BD. In the clinical course of BD, the circadian rhythm dysfunctions may act as predictors for the first onset of BD and the relapse of mood episodes...
June 5, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29867609/the-influence-of-myelin-oligodendrocyte-glycoprotein-on-white-matter-abnormalities-in-different-onset-age-of-drug-na%C3%A3-ve-depression
#9
Feng Wu, Lingtao Kong, Yue Zhu, Qian Zhou, Xiaowei Jiang, Miao Chang, Yifang Zhou, Yang Cao, Ke Xu, Fei Wang, Yanqing Tang
Neurophysiological mechanisms of white matter abnormalities in the earlier onset major depressive disorder (eoMDD, onset age ≤25 years old) differ from that in the later onset MDD (loMDD, onset age >25 years old). Myelin oligodendrocyte glycoprotein (MOG) is an important factor influencing white matter development. The influence of MOG on white matter in MDD of different age onset need to be explored. We compared MOG plasma concentrations and diffusion tensor imaging (DTI) data in 35 first-episode medication-naïve MDD patients (23 eoMDD, 12 loMDD), and 32 healthy controls (HC, 17 younger, 15 older)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29862493/characteristics-of-depressive-and-bipolar-disorder-patients-with-mixed-features
#10
L Tondo, G H Vázquez, M Pinna, P A Vaccotto, R J Baldessarini
OBJECTIVE: To assess differences between subjects with vs. without mixed features in major affective disorders. METHODS: In 3099 out-patient subjects with DSM-5 major depressive disorder (MDD, n = 1921) or bipolar disorders (BD, n = 1178), we compared those with (Mx) vs. without (Non-Mx) mixed features (agitated-irritable depression or dysphoric [hypo]mania) in an index episode. RESULTS: Prevalence of Mx averaged 21.9% [CI: 20.5-23.4] overall, ranking: BD-II > BD-I > MDD, and in BD depression ≥ [hypo]mania > MDD...
June 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29859378/clinical-characteristics-and-outcomes-of-psychotic-depression-in-the-northern-finland-birth-cohort-1966
#11
Miika Nietola, Anni Heiskala, Tanja Nordström, Jouko Miettunen, Jyrki Korkeila, Erika Jääskeläinen
BACKGROUND: Psychotic depression (PD) is heavily understudied despite high mortality and the severe course of illness. A majority of the studies conducted so far are also largely based on selected clinical samples. The aim of this study was to examine the clinical characteristics of PD in a representative prospective birth cohort sample. METHODS: The Northern Finland Birth Cohort 1966 is a well-known prospective population-based cohort including 12 058 people followed since mid-pregnancy...
May 30, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29792585/assessment-in-work-productivity-and-the-relationship-with-cognitive-symptoms-atworc-primary-analysis-from-a-canadian-open-label-study-of-vortioxetine-in-patients-with-major-depressive-disorder-mdd
#12
Pratap Chokka, Joanna Bougie, Emmanouil Rampakakis, Jean Proulx
OBJECTIVE: The Assessment in Work Productivity and the Relationship with Cognitive Symptoms (AtWoRC) study aimed to assess the association between cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a major depressive episode (MDE). METHODS: Patients diagnosed with major depressive disorder (MDD) and treated with vortioxetine independently of study enrollment were assessed over 52 weeks at visits that emulated a real-life setting...
May 24, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29790237/towards-a-new-classification-of-stable-phase-schizophrenia-into-major-and-simple-neuro-cognitive-psychosis-results-of-unsupervised-machine-learning-analysis
#13
Buranee Kanchanatawan, Sira Sriswasdi, Supaksorn Thika, Drozdstoy Stoyanov, Sunee Sirivichayakul, André F Carvalho, Michel Geffard, Michael Maes
RATIONALE: Deficit schizophrenia, as defined by the Schedule for Deficit Syndrome, may represent a distinct diagnostic class defined by neurocognitive impairments coupled with changes in IgA/IgM responses to tryptophan catabolites (TRYCATs). Adequate classifications should be based on supervised and unsupervised learning rather than on consensus criteria. METHODS: This study used machine learning as means to provide a more accurate classification of patients with stable phase schizophrenia...
May 23, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29787958/altered-tryptophan-catabolite-concentrations-in-major-depressive-disorder-and-associated-changes-in-hippocampal-subfield-volumes
#14
Kelly Doolin, Kelly A Allers, Sina Pleiner, Andre Liesener, Chloe Farrell, Leonardo Tozzi, Erik O'Hanlon, Darren Roddy, Thomas Frodl, Andrew Harkin, Veronica O'Keane
BACKGROUND: Tryptophan depletion is a well-replicated biological finding in Major Depressive Disorder (MDD). The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the pathogenesis of depression. IDO expression is driven by inflammatory cytokines, providing a putative link between inflammation and neuropathology. This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC)...
May 19, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29771271/discontinuing-treatment-against-medical-advice-the-role-of-perceived-autonomy-support-from-providers-in-relapsing-remitting-multiple-sclerosis
#15
Morgan Glusman, Amanda Bruce, Joanie Thelen, Julia Smith, Sharon Lynch, Delwyn Catley, Kimberley K Bennett, Jared Bruce
Background: Long-term medication adherence is problematic among patients with chronic medical conditions. To our knowledge, this was the first study to examine factors associated with nonadherence among patients with relapsing-remitting multiple sclerosis who discontinue disease-modifying treatments against medical advice. Purpose: To examine differences in perceived provider autonomy support between disease-modifying treatment-adherent relapsing-remitting multiple sclerosis patients and relapsing-remitting multiple sclerosis patients who discontinued disease-modifying treatments against medical advice...
May 16, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29768955/results-of-a-real-world-study-on-vortioxetine-in-patients-with-major-depressive-disorder-in-south-east-asia-revida
#16
Cheuk Ngen Chin, Azhar Zain, Solaphat Hemrungrojn, Eng Khean Ung, Patanon Kwansanit, Koon Choong Au Yong, Marvin Swee Woon Chong, Chalowat Inpa, Teck Hoe Yen, Boon Beng David Yeoh, Liam Kai Tay, Carmina Bernardo, Lionel Chee-Chong Lim, Chin Hong Yap, Calvin Fones, Ashwini Nayak, Lars Nelleman
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from Aug 2016 to Apr 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore, and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29765205/patterns-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episode-and-their-impact-on-long-term-outcome-a-naturalistic-study-with-5-year-follow-up
#17
Kanglai Li, Jiong Tao, Yuemei Li, Minhua Chen, Xiuhua Wu, Yingtao Liao, Xiaolan Lin, Zhaoyu Gan
Background: The aim of the study was to describe and compare the patterns of medication persistence among patients with unipolar depression (UD) or bipolar depression in a 5-year follow-up, and explore their impact on long-term outcome. Patients and methods: A total of 333 eligible patients with current major depressive episode were observed and followed up from the first index prescription for 5 years. Lack of persistence or treatment interruption was defined as a gap of at least 2 consecutive months without taking any medication...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29704324/voxel-wise-brain-wide-functional-connectivity-abnormalities-in-first-episode-drug-naive-patients-with-major-depressive-disorder
#18
Xilong Cui, Feng Liu, Jindong Chen, Guangrong Xie, Renrong Wu, Zhikun Zhang, Huafu Chen, Jingping Zhao, Wenbin Guo
Due to different foci and single sample across studies, abnormal functional connectivity (FC) has been implicated in the pathophysiology of major depressive disorder (MDD) with inconsistent results. The inconsistency may reflect a combination of clinical and methodological variability, which leads to limited reproducibility of these findings. The samples included 59 patients with MDD and 31 controls from Sample 1, 29 patients with MDD and 24 controls from Sample 2, and 31 patients with schizophrenia and 37 controls from Sample 3...
June 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29684091/impaired-visual-working-and-verbal-memory-in-first-episode-drug-naive-patients-with-major-depressive-disorder-in-a-chinese-population
#19
Ce Chen, Wen-Hui Jiang, Wei Wang, Xian-Cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-Ge Gao
Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, using the CogState battery (CSB) Chinese language version, we evaluated the visual, working, and verbal memory in first-episode drug-naive patients and medicated patients with MDD in a Chinese population. We measured the cognitive function in first-episode drug-naïve patients (n = 36), medicated MDD patients (n = 71), and age- and sex-matched healthy control subjects (n = 59) in a Chinese population...
2018: PloS One
https://www.readbyqxmd.com/read/29653349/the-role-of-lifetime-anxiety-history-in-the-course-of-bipolar-spectrum-disorders
#20
Madison K Titone, Rachel D Freed, Jared K O'Garro-Moore, Andrew Gepty, Tommy H Ng, Jonathan P Stange, Lyn Y Abramson, Lauren B Alloy
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young adults (aged 17-26) with milder forms of BSDs (i.e., bipolar-II, cyclothymia, BD-NOS). First, bivariate analyses assessed differences in baseline clinical characteristics between participants with and without DSM-IV anxiety diagnoses...
June 2018: Psychiatry Research
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