keyword
MENU ▼
Read by QxMD icon Read
search

First Major Depressive Episode

keyword
https://www.readbyqxmd.com/read/28298187/icanadapt-early-protocol-randomised-controlled-trial-rct-of-clinician-supervised-transdiagnostic-internet-delivered-cognitive-behaviour-therapy-icbt-for-depression-and-or-anxiety-in-early-stage-cancer-survivors-vs-treatment-as-usual
#1
M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith, G Andrews
BACKGROUND: This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/DESIGN: Early stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28287187/similarities-and-differences-of-functional-connectivity-in-drug-na%C3%A3-ve-first-episode-adolescent-and-young-adult-with-major-depressive-disorder-and-schizophrenia
#2
Shengnan Wei, Fay Womer, Haiyang Geng, Xiaowei Jiang, Qian Zhou, Miao Chang, Yifang Zhou, Yanqing Tang, Fei Wang
Major depressive disorder (MDD) and schizophrenia (SZ) are considered two distinct psychiatric disorders. Yet, they have considerable overlap in symptomatology and clinical features, particularly in the initial phases of illness. The amygdala and prefrontal cortex (PFC) appear to have critical roles in these disorders; however, abnormalities appear to manifest differently. In our study forty-nine drug-naïve, first-episode MDD, 45 drug-naïve, first-episode SZ, and 50 healthy control (HC) participants from 13 to 30 years old underwent resting-state functional magnetic resonance imaging...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277876/the-use-of-adjunctive-antipsychotics-to-treat-depression-in-uk-primary-care
#3
F X Lamy, D Saragoussi, M E Johnson, A Guiraud-Diawara, K T Jørgensen, J Y Loze, A Maguire
OBJECTIVE: Adjunctive antipsychotic therapy can be prescribed to patients with depression who have inadequate response to antidepressants. This study aimed to describe the use of adjunctive antipsychotics over a time period that includes the authorization in 2010 of prolonged-release quetiapine as the first adjunct antipsychotic to be used in major depressive disorder in the UK. RESEARCH DESIGN AND METHODS: Adults with an episode of depression between January 1, 2005 and July 31, 2013 were identified from antidepressant prescriptions and depression diagnoses in the UK Clinical Practice Research Datalink...
March 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28271818/mixed-up-about-how-to-diagnose-and-treat-mixed-features-in-major-depressive-episodes
#4
Stephen M Stahl
The classical point of view-that major depressive episodes (MDEs), no matter what additional symptoms are present, should be treated first line with antidepressants-is now giving way to new a notion. The idea is that MDEs mixed with a few symptoms of mania/hypomania should be viewed very differently in terms of their natural history, clinical outcome, and treatment, and perhaps certain antipsychotics should be given as first-line treatment rather than antidepressant monotherapy.
March 8, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28225084/rumination-and-default-mode-network-subsystems-connectivity-in-first-episode-drug-naive-young-patients-with-major-depressive-disorder
#5
Xueling Zhu, Qiuling Zhu, Huaizhen Shen, Weihua Liao, Fulai Yuan
Neuroimaging evidence implicates the association between rumination and default mode network (DMN) in major depressive disorder (MDD). However, the relationship between rumination and DMN subsystems remains incompletely understood, especially in patients with MDD. Thirty-three first-episode drug-naive patients with MDD and thirty-three healthy controls (HCs) were enrolled and underwent resting-sate fMRI scanning. Functional connectivity analysis was performed based on 11 pre-defined regions of interest (ROIs) for three DMN subsystems: the midline core, dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183022/temporal-sequencing-of-nicotine-dependence-and-major-depressive-disorder-a-u-s-national-study
#6
José M Martínez-Ortega, Silvia Franco, Jorge M Rodríguez-Fernández, Luis Gutiérrez-Rojas, Shuai Wang, Manuel Gurpegui
Major Depressive Disorder (MDD) and Nicotine dependence (ND) often co-occur. However, little attention has been given to the temporal order between the two disorders. We compared the sociodemographic and clinical characteristics of individuals whose onset of ND preceded (ND-prior) or followed the onset of MDD (MDD-prior). Binary logistic regression models were computed to compare ND-prior (n=546) and MDD-prior (n=801) individuals from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=43,093)...
February 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28177952/clinical-factors-related-to-acute-electroconvulsive-therapy-outcome-for-patients-with-major-depressive-disorder
#7
Cheng-Chung Chen, Ching-Hua Lin, Wei-Cheng Yang, Ming-Chao Chen
The aim of this study was to explore the significant predictors associated with electroconvulsive therapy (ECT) outcome for patients with major depressive disorder. Major depressive disorder inpatients (N=130) requiring ECT were recruited from a major psychiatric center in South Taiwan. ECT was generally performed for a maximum of 12 sessions. Symptom severity was assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17) and Clinical Global Impression of Severity (CGI-S) before ECT, after every three ECT sessions, and after the last ECT...
February 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28176413/anomalous-single-subject-based-morphological-cortical-networks-in-drug-naive-first-episode-major-depressive-disorder
#8
Taolin Chen, Keith M Kendrick, Jinhui Wang, Min Wu, Kaiming Li, Xiaoqi Huang, Yuejia Luo, Su Lui, John A Sweeney, Qiyong Gong
Major depressive disorder (MDD) has been associated with disruptions in the topological organization of brain morphological networks in group-level data. Such disruptions have not yet been identified in single-patients, which is needed to show relations with symptom severity and to evaluate their potential as biomarkers for illness. To address this issue, we conducted a cross-sectional structural brain network study of 33 treatment-naive, first-episode MDD patients and 33 age-, gender-, and education-matched healthy controls (HCs)...
February 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28144920/the-impact-of-a-single-nucleotide-polymorphism-in-sigmar1-on-depressive-symptoms-in-major-depressive-disorder-and-bipolar-disorder
#9
Laura Mandelli, Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Alessandro Serretti
INTRODUCTION: Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). We aimed to evaluate the same polymorphism in both MDD and bipolar disorder (BD) as well as its relationship to response to treatment with antidepressants and mood stabilizers...
January 31, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28129464/relationship-between-the-hippocampal-shape-abnormality-and-serum-cortisol-levels-in-first-episode-and-drug-na%C3%A3-ve-major-depressive-disorder-patients
#10
Rieko Watanabe, Shingo Kakeda, Keita Watanabe, Xiaodan Liu, Asuka Katsuki, Wakako Umeno-Nakano, Hikaru Hori, Osamu Abe, Reiji Yoshimura, Yukunori Korogi
BACKGROUND: We aimed to investigate the relationship between the hippocampal shape deformations and the serum cortisol levels in first-episode and drug-naïve major depression disorder (MDD) patients. METHODS: Thirty first-episode and drug-naïve MDD patients and 40 healthy subjects were recruited. High-resolution T1-weighted imaging and morning blood samples for cortisol measurement were obtained from all MDD patients and healthy subjects. In the hippocampal shape analysis, we compared the hippocampal shape between MDD patients and healthy subjects and evaluated the linear correlation between hippocampal shape deformations and the serum cortisol levels in MDD patients and healthy subjects...
January 27, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28118287/abnormal-functional-connectivity-of-the-amygdala-in-first-episode-and-untreated-adult-major-depressive-disorder-patients-with-different-ages-of-onset
#11
Jing Ye, Zonglin Shen, Xiufeng Xu, Shuran Yang, Wei Chen, Xiaoyan Liu, Yi Lu, Fang Liu, Jin Lu, Na Li, Xuejin Sun, Yuqi Cheng
Major depressive disorder (MDD) is a common mental disorder with high morbidity. As a part of the limbic system, the amygdala is important in the processing of emotional information. Structural and functional connectivity (FC) abnormalities in the amygdala have been observed in MDD patients. The present study was carried out to identify the features of amygdala FC in adult MDD patients with different ages of onset. Sixty-nine first-episode and untreated MDD patients and 81 healthy controls (CTLs) were included in this study and underwent 3D structural imaging and resting-state functional MRI scanning...
January 21, 2017: Neuroreport
https://www.readbyqxmd.com/read/28101340/pseudo-continuous-arterial-spin-labeling-imaging-of-cerebral-blood-perfusion-asymmetry-in-drug-na%C3%A3-ve-patients-with-first-episode-major-depression
#12
Guangdong Chen, Haiman Bian, Deguo Jiang, Mingwei Cui, Shengzhang Ji, Mei Liu, Xu Lang, Chuanjun Zhuo
Many previous studies have reported that regional cerebral blood flow (rCBF) aberrations may be one of the pathological characteristics of depression and rCBF has demonstrated a certain degree of asymmetry. However, studies investigating the cerebral blood perfusion asymmetry changes of drug-naïve patients experiencing their first episode of major depression using pseudo-continuous arterial spin labeling (pCASL) are rare. Ten drug-naïve patients experiencing their first major depression episode and 15 healthy volunteers were enrolled in the current study...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28086851/efficacy-of-intermittent-theta-burst-stimulation-itbs-and-10-hz-high-frequency-repetitive-transcranial-magnetic-stimulation-rtms-in-treatment-resistant-unipolar-depression-study-protocol-for-a-randomised-controlled-trial
#13
Samuel Bulteau, Veronique Sébille, Guillemette Fayet, Veronique Thomas-Ollivier, Thibault Deschamps, Annabelle Bonnin-Rivalland, Edouard Laforgue, Anne Pichot, Pierre Valrivière, Elisabeth Auffray-Calvier, June Fortin, Yann Péréon, Jean-Marie Vanelle, Anne Sauvaget
BACKGROUND: The treatment of depression remains a challenge since at least 40% of patients do not respond to initial antidepressant therapy and 20% present chronic symptoms (more than 2 years despite standard treatment administered correctly). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy but still not ideal. Intermittent Theta Burst Stimulation (iTBS), which has only been used recently in clinical practice, could have a faster and more intense effect compared to conventional protocols, including 10-Hz high-frequency rTMS (HF-rTMS)...
January 13, 2017: Trials
https://www.readbyqxmd.com/read/28077120/altered-fractional-amplitude-of-low-frequency-fluctuation-associated-with-cognitive-dysfunction-in-first-episode-drug-na%C3%A3-ve-major-depressive-disorder-patients
#14
Manli Huang, Shaojia Lu, Liang Yu, Lingjiang Li, Peng Zhang, Jianbo Hu, Weihua Zhou, Shaohua Hu, Ning Wei, Jinwen Huang, Jian Weng, Yi Xu
BACKGROUND: Previous studies have demonstrated that abnormities of both resting-state brain activity and cognitive dysfunction are frequently observed in patients with major depressive disorder (MDD). However, the underlying relationship between these two aspects is less investigated. In this context, the aim of the present study was to investigate the association between cognitive dysfunction and altered resting-state brain function in first-episode drug-naïve MDD patients. METHODS: Twenty-five drug-naïve MDD patients and twenty-six age-, sex-, and education-matched normal controls were recruited in this study...
January 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28068461/a-new-prediction-model-for-evaluating-treatment-resistant-depression
#15
Alexander Kautzky, Pia Baldinger-Melich, Georg S Kranz, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: Despite a broad arsenal of antidepressants, about a third of patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool of the Group for the Study of Resistant Depression and machine learning, we intended to draw new insights featuring 48 clinical, sociodemographic, and psychosocial predictors for treatment outcome. METHOD: Patients were enrolled starting from January 2000 and diagnosed according to DSM-IV...
February 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28053535/atypical-major-depressive-episode-as-initial-presentation-of-intracranial-germinoma-in-a-male-adolescent
#16
Yi-Ting Chen, Kuan-Pin Su, Jane Pei-Chen Chang
A 17-year-old adolescent boy presented with atypical major depressive episode (MDE) without specific focal neurological signs for 6 months. He had a diagnosis of intra-cranial germinoma, and the atypical MDE symptoms subsided after the operation. However, he had a relapse of atypical MDE 7 months after the first surgery. His mood and binge eating symptoms subsided, but intractable body weight gain only partially improved after treatment. When encountering manifestations of depression with atypical features, especially with binge eating symptoms in male children and adolescents, with early onset age, no family history, and prolonged depressive episodes, clinicians should consider not only mood disorders including bipolar spectrum disorders but also organic brain lesions such as intracranial germinoma...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28053534/detailed-course-of-depressive-symptoms-and-risk-for-developing-depression-in-late-adolescents-with-subthreshold-depression-a-cohort-study
#17
Ran Jinnin, Yasumasa Okamoto, Koki Takagaki, Yoshiko Nishiyama, Takanao Yamamura, Yuri Okamoto, Yoshie Miyake, Yoshitake Takebayashi, Keisuke Tanaka, Yoshinori Sugiura, Haruki Shimoda, Norito Kawakami, Toshi A Furukawa, Shigeto Yamawaki
PURPOSE: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year. PATIENTS AND METHODS: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2,494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28049079/prediction-of-motivational-impairment-12-month-follow-up-of-the-randomized-controlled-trial-on-extended-early-intervention-for-first-episode-psychosis
#18
W C Chang, V W Y Kwong, G H K Chan, O T T Jim, E S K Lau, C L M Hui, S K W Chan, E H M Lee, E Y H Chen
BACKGROUND: Amotivation is prevalent in first-episode psychosis (FEP) patients and is a major determinant of functional outcome. Prediction of amotivation in the early stage of psychosis, however, is under-studied. We aimed to prospectively examine predictors of amotivation in FEP patients in a randomized-controlled trial comparing a 1-year extension of early intervention (Extended EI, 3-year EI) with step-down psychiatric care (SC, 2-year EI). METHODS: One hundred sixty Chinese patents were recruited from a specialized EI program for FEP in Hong Kong after they have completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months...
March 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#19
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28012422/altered-patterns-of-association-between-cortical-thickness-and-subcortical-volume-in-patients-with-first-episode-major-depressive-disorder-a-structural-mri-study
#20
Ke Zhao, Haiyan Liu, Rui Yan, Lingling Hua, Yu Chen, Jiabo Shi, Zhijian Yao, Qing Lu
Depressed individuals may exhibit changes in cortical thickness and subcortical volume. However, we know little about their associated connection patterns in the brain's neural circuits. This study explored correlations between overall cortical thickness and the volume of several subcortical structures in first episode major depressive disorder (MDD) patients. Thirty-six untreated individuals experiencing their first episode of MDD were compared with healthy controls (n=41). Their brains were imaged by T1-weighted MRI, allowing the measurement of cortical thickness and the volume of subcortical structures...
February 28, 2017: Psychiatry Research
keyword
keyword
27523
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"