keyword
https://read.qxmd.com/read/38477708/ionic-diffusive-nanomemristors-with-dendritic-competition-and-cooperation-functions-for-ultralow-voltage-neuromorphic-computing
#21
JOURNAL ARTICLE
Jialin Meng, Jieru Song, Yuqing Fang, Tianyu Wang, Hao Zhu, Li Ji, Qing-Qing Sun, David Wei Zhang, Lin Chen
Realization of dendric signal processing in the human brain is of great significance for spatiotemporal neuromorphic engineering. Here, we proposed an ionic dendrite device with multichannel communication, which could realize synaptic behaviors even under an ultralow action potential of 80 mV. The device not only could simulate one-to-one information transfer of axons but also achieve a many-to-one modulation mode of dendrites. By the adjustment of two presynapses, Pavlov's dog conditioning experiment was learned successfully...
March 13, 2024: ACS Nano
https://read.qxmd.com/read/38474242/development-of-genetically-encoded-fluorescent-ksr1-based-probes-to-track-ceramides-during-phagocytosis
#22
JOURNAL ARTICLE
Vladimir Girik, Larissa van Ek, Isabelle Dentand Quadri, Maral Azam, María Cruz Cobo, Marion Mandavit, Isabelle Riezman, Howard Riezman, Anne-Claude Gavin, Paula Nunes-Hasler
Ceramides regulate phagocytosis; however, their exact function remains poorly understood. Here, we sought (1) to develop genetically encoded fluorescent tools for imaging ceramides, and (2) to use them to examine ceramide dynamics during phagocytosis. Fourteen enhanced green fluorescent protein (EGFP) fusion constructs based on four known ceramide-binding domains were generated and screened. While most constructs localized to the nucleus or cytosol, three based on the CA3 ceramide-binding domain of kinase suppressor of ras 1 (KSR1) localized to the plasma membrane or autolysosomes...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468031/morphology-and-fractal-based-classifications-of-neurons-and-microglia-in-two-and-three-dimensions
#23
JOURNAL ARTICLE
Audrey L Karperien, Herbert F Jelinek
Microglia and neurons live physically intertwined, intimately related structurally and functionally in a dynamic relationship in which microglia change continuously over a much shorter timescale than do neurons. Although microglia may unwind and depart from the neurons they attend under certain circumstances, in general, together both contribute to the fractal topology of the brain that defines its computational capabilities. Both neuronal and microglial morphologies are well-described using fractal analysis complementary to more traditional measures...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38467561/dynamic-molecular-interphases-regulated-by-trace-dual-electrolyte-additives-for-ultralong-lifespan-and-dendrite-free-zinc-metal-anode
#24
JOURNAL ARTICLE
Hong-Bo Chen, Huan Meng, Tong-Rui Zhang, Qing Ran, Jie Liu, Hang Shi, Gao-Feng Han, Tong-Hui Wang, Zi Wen, Xing-You Lang, Qing Jiang
Metallic zinc is a promising anode material for rechargeable aqueous multivalent metal-ion batteries due to its high capacity and low cost. However, the practical use is always beset by severe dendrite growth and parasitic side reactions occurring at anode/electrolyte interface. Here we demonstrate that dynamic molecular interphases caused by trace dual electrolyte additives of D-mannose and sodium lignosulfonate for ultralong-lifespan and dendrite-free zinc anode. Triggered by plating and stripping electric fields, the D-mannose and lignosulfonate species are alternately and reversibly (de-)adsorbed on Zn metal, respectively, to accelerate Zn2+ transportation for uniform Zn nucleation and deposition and inhibit side reactions for high coulombic efficiency...
March 11, 2024: Angewandte Chemie
https://read.qxmd.com/read/38465928/cationic-nanoemulsion-encapsulated-retinoic-acid-as-an-adjuvant-to-promote-ova-specific-systemic-and-mucosal-responses
#25
JOURNAL ARTICLE
Guo-Cheng Li, Hui-Fang Li, Zhe Jin, Rang Feng, Yan Deng, Hao Cheng, Hai-Bo Li
Cationic nanostructures have emerged as an adjuvant and antigen delivery system that enhances dendritic cell maturation, ROS generation, and antigen uptake and then promotes antigen-specific immune responses. In recent years, retinoic acid (RA) has received increasing attention due to its effect in activating the mucosal immune response; however, in order to use RA as a mucosal adjuvant, it is necessary to solve the problem of its dissolution, loading, and delivery. Here, we describe a cationic nanoemulsion-encapsulated retinoic acid (CNE-RA) delivery system composed of the cationic lipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOTAP), retinoic acid, squalene as the oil phase, polysorbate 80 as surfactant, and sorbitan trioleate 85 as co-surfactant...
February 23, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38463893/numerical-simulation-of-the-effect-of-hypergravity-on-the-dendritic-growth-characteristics-of-aluminum-alloys
#26
JOURNAL ARTICLE
Yanying Zhang, Ruifeng Dou, Junsheng Wang, Xunliang Liu, Zhi Wen
The cellular automata-lattice Boltzmann method is used to simulate the dendritic growth process of aluminum alloys under the action of hypergravity by performing coupling heat and mass transfer, solidification and flow. The dendrite arm spacing, growth rate, and dendrite morphology vary greatly with the size and direction of hypergravity, and solute segregation occurs. Compared with the gravity of the earth (1 g), hypergravity strongly strengthens the buoyancy-driven flow and considerably affects the morphology of the solidified grain...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38461575/maternal-exposure-to-deltamethrin-during-pregnancy-and-lactation-impairs-neurodevelopment-of-male-offspring
#27
JOURNAL ARTICLE
Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wang
Deltamethrin (DM) is a highly effective and widely used pyrethroid pesticide. It is an environmental factor affecting public and occupational health and exerts direct toxic effects on the central nervous system. As the major target organs for neurotoxicity of DM, the hippocampus and the cerebellum are critical to the learning and motor function. Pregnant Wistar rats were randomly divided into four groups and gavaged at doses of 0, 1, 4or 10 mg/kg/d DM from gestational day (GD) 0 to postnatal day (PN) 21...
March 9, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38461368/freezing-shrinkage-dynamics-and-surface-dendritic-growth-of-floating-refractory-alloy-droplets-in-outer-space
#28
JOURNAL ARTICLE
Haipeng Wang, Hui Liao, Liang Hu, Chenhui Zheng, Jian Chang, Dingnan Liu, Mingxing Li, Jiongfei Zhao, Wenjun Xie, Bingbo We
The freezing shrinkage and dendritic growth are of great importance for various alloys solidified from high temperature liquids to solids since they dominate microstructure patterns and follow-up processing. However, the microgravity freezing shrinkage dynamics is scarcely explored on the ground as it is hard to suppress the strong natural convection inside liquid alloys. Here, we conduct a series of in-orbit solidification experiments aboard China Space Station with a long-term stable 10-5 g0 microgravity condition...
March 9, 2024: Advanced Materials
https://read.qxmd.com/read/38459645/regulating-electron-filling-and-orbital-occupancy-of-anti-bonding-states-of-transition-metal-nitride-heterojunction-for-high-areal-capacity-lithium-sulfur-full-batteries
#29
JOURNAL ARTICLE
Jintao Liu, Lianghao Yu, Qiwen Ran, Xi'an Chen, Xueyu Wang, Xuedong He, Huile Jin, Tao Chen, Jun Song Chen, Daying Guo, Shun Wang
The commercialization of lithium-sulfur (Li-S) battery is seriously hindered by the shuttle behavior of lithium (Li) polysulfide, slow conversion kinetics, and Li dendrite growth. Herein, a novel hierarchical p-type iron nitride and n-type vanadium nitride (p-Fe2 N/n-VN) heterostructure with optimal electronic structure, confined in vesicle-like N-doped nanofibers (p-Fe2 N/n-VN⊂PNCF), is meticulously constructed to work as "one stone two birds" dual-functional hosts for both the sulfur cathode and Li anode...
March 8, 2024: Small
https://read.qxmd.com/read/38450041/chemical-ltp-induces-confinement-of-bdnf-mrna-under-dendritic-spines-and-bdnf-protein-accumulation-inside-the-spines
#30
JOURNAL ARTICLE
Giorgia Bimbi, Enrico Tongiorgi
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in neuronal development and synaptic plasticity. The discovery that BDNF mRNA can be transported in neuronal dendrites in an activity-dependent manner has suggested that its local translation may support synapse maturation and plasticity. However, a clear demonstration that BDNF mRNA is locally transported and translated at activated synapses in response to long-term potentiation (LTP) is still lacking. Here, we study the dynamics of BDNF mRNA dendritic trafficking following the induction of chemical LTP (cLTP)...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38443340/deciphering-the-tumor-immune-microenvironment-of-imatinib-resistance-in-advanced-gastrointestinal-stromal-tumors-at-single-cell-resolution
#31
JOURNAL ARTICLE
Xuechao Liu, Jing Yu, Yi Li, Hailei Shi, Xuelong Jiao, Xiaodong Liu, Dong Guo, Zequn Li, Yulong Tian, Fan Dai, Zhaojian Niu, Yanbing Zhou
The heterogeneous nature of tumors presents a considerable obstacle in addressing imatinib resistance in advanced cases of gastrointestinal stromal tumors (GIST). To address this issue, we conducted single-cell RNA-sequencing in primary tumors as well as peritoneal and liver metastases from patients diagnosed with locally advanced or advanced GIST. Single-cell transcriptomic signatures of tumor microenvironment (TME) were analyzed. Immunohistochemistry and multiplex immunofluorescence staining were used to further validate it...
March 5, 2024: Cell Death & Disease
https://read.qxmd.com/read/38442194/an-inhibitory-immunoreceptor-allergin-1-regulates-the-intestinal-dysbiosis-and-barrier-function-in-mice
#32
JOURNAL ARTICLE
Yu-Hsien Lin, Satoko Tahara-Hanaoka, Nozomu Obana, Shinji Fukuda, Akira Shibuya
The intestinal barrier consists of mucosal, epithelial, and immunological barriers and serves as a dynamic interface between the host and its environment. Disruption of the intestinal barrier integrity is a leading cause of various gastrointestinal diseases, such as inflammatory bowel disease. The homeostasis of the intestinal barrier is tightly regulated by crosstalk between gut microbes and the immune system; however, the implication of the immune system on the imbalance of gut microbes that disrupts barrier integrity remains to be fully elucidated...
March 5, 2024: International Immunology
https://read.qxmd.com/read/38440150/nargbp2-together-with-gkap-and-shank3-forms-a-dynamic-layered-structure
#33
JOURNAL ARTICLE
Sang-Eun Lee, Sunghoe Chang
nArgBP2, a protein whose disruption is implicated in intellectual disability, concentrates in excitatory spine-synapses. By forming a triad with GKAP and SHANK, it regulates spine structural rearrangement. We here find that GKAP and SHANK3 concentrate close to the synaptic contact, whereas nArgBP2 concentrates more centrally in the spine. The three proteins collaboratively form biomolecular condensates in living fibroblasts, exhibiting distinctive layered localizations. nArgBP2 concentrates in the inner phase, SHANK3 in the outer phase, and GKAP partially in both...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38438224/a-multilocus-dendritic-boronic-acid-functionalized-magnetic-nanoparticle-for-capturing-circulating-tumor-cells-in-the-peripheral-blood-of-mice-with-metastatic-breast-cancer
#34
JOURNAL ARTICLE
Yue Chen, Zhengkun Tang, Jiajia Liu, Chuanyang Ren, Yiwen Zhang, Huarong Xu, Qing Li, Qian Zhang
BACKGROUND: Dynamic fluctuation of circulating tumor cells (CTCs) can serve as an indicator of tumor progression. However, the sensitive isolation of CTCs remains extremely challenging due to their rarity and heterogeneity. Against this dilemma, dendritic boronic acid-modified magnetic nanoparticles (MNPs) were prepared in this study, and polyethyleneimine (PEI) was utilized as a scaffold to significantly increase the number of boronic acid moieties. Then the novel developed material was applied to monitor the number of CTCs in mice with metastatic breast cancer to evaluate the therapeutic effects of matrine (Mat), doxorubicin (Dox), and Mat in combination with Dox...
April 8, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38437226/how-neuronal-morphology-impacts-the-synchronisation-state-of-neuronal-networks
#35
JOURNAL ARTICLE
Robert P Gowers, Susanne Schreiber
The biophysical properties of neurons not only affect how information is processed within cells, they can also impact the dynamical states of the network. Specifically, the cellular dynamics of action-potential generation have shown relevance for setting the (de)synchronisation state of the network. The dynamics of tonically spiking neurons typically fall into one of three qualitatively distinct types that arise from distinct mathematical bifurcations of voltage dynamics at the onset of spiking. Accordingly, changes in ion channel composition or even external factors, like temperature, have been demonstrated to switch network behaviour via changes in the spike onset bifurcation and hence its associated dynamical type...
March 4, 2024: PLoS Computational Biology
https://read.qxmd.com/read/38436502/establishment-of-an-in-situ-model-to-explore-the-tumor-immune-microenvironment-in-head-and-neck-squamous-cell-carcinoma
#36
JOURNAL ARTICLE
Congxian Lu, Yuteng Yang, Mingjun Zhang, Jiaxuan Li, Hao Song, Hongfei Zhao, Yakui Mou, Yumei Li, Xicheng Song
OBJECTIVE: Establish an in situ model for investigating HNSCC, focusing on tumor growth, metastasis, and the immune microenvironment. METHODS: Generated a monoclonal SCCVII-ZsGreen cell line through lentiviral transfection. Selected monoclonal lines with growth rates similar to the original SCCVII for in vivo tumorigenesis. Monitored tumor development and metastasis through fluorescence in vivo imaging. Employed immunohistochemistry to assess immune cell distribution in the tumor microenvironment...
March 4, 2024: Head & Neck
https://read.qxmd.com/read/38432881/bidirectional-mechanism-of-comorbidity-of-depression-and-insomnia-based-on-synaptic-plasticity
#37
JOURNAL ARTICLE
Fanhao Meng, Long Wang
Insomnia is one of the most common accompanying symptoms of depression, with both sharing highly overlapping molecular pathways. The same pathological changes can trigger comorbidity of insomnia and depression, which further forms a vicious cycle with the involvement of more mechanisms and disease progression. Thus, understanding the potential interaction mechanisms between insomnia and depression is critical for clinical diagnosis and treatment. Comorbidity genetic factors, the hypothalamic-pituitary-adrenal axis, along with circadian rhythms of cortisol and the brain reward mechanism, are important ways in contributing to the comorbidity occurrence and development...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38431385/the-immunogenicity-of-p24-protein-from-hiv-1-virus-is-strongly-supported-and-modulated-by-coupling-with-liposomes-and-mannan
#38
JOURNAL ARTICLE
K Zachová, E Bartheldyová, F Hubatka, M Křupka, N Odehnalová, P Turánek Knötigová, N Vaškovicová, K Sloupenská, R Hromádka, E Paulovičová, R Effenberg, M Ledvina, M Raška, J Turánek
Anti-viral and anti-tumor vaccines aim to induce cytotoxic CD8+ T cells (CTL) and antibodies. Conserved protein antigens, such as p24 from human immunodeficiency virus, represent promising component for elicitation CTLs, nevertheless with suboptimal immunogenicity, if formulated as recombinant protein. To enhance immunogenicity and CTL response, recombinant proteins may be targeted to dendritic cells (DC) for cross presentation on MHCI, where mannose receptor and/or other lectin receptors could play an important role...
May 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38429414/modeling-t-cell-temporal-response-to-cancer-immunotherapy-rationalizes-development-of-combinatorial-treatment-protocols
#39
JOURNAL ARTICLE
Oren Barboy, Akhiad Bercovich, Hanjie Li, Yaniv Eyal-Lubling, Adam Yalin, Yuval Shapir Itai, Kathleen Abadie, Mor Zada, Eyal David, Shir Shlomi-Loubaton, Yonatan Katzenelenbogen, Diego Adhemar Jaitin, Chamutal Gur, Ido Yofe, Tali Feferman, Merav Cohen, Rony Dahan, Evan W Newell, Aviezer Lifshitz, Amos Tanay, Ido Amit
Successful immunotherapy relies on triggering complex responses involving T cell dynamics in tumors and the periphery. Characterizing these responses remains challenging using static human single-cell atlases or mouse models. To address this, we developed a framework for in vivo tracking of tumor-specific CD8+ T cells over time and at single-cell resolution. Our tools facilitate the modeling of gene program dynamics in the tumor microenvironment (TME) and the tumor-draining lymph node (tdLN). Using this approach, we characterize two modes of anti-programmed cell death protein 1 (PD-1) activity, decoupling induced differentiation of tumor-specific activated precursor cells from conventional type 1 dendritic cell (cDC1)-dependent proliferation and recruitment to the TME...
March 1, 2024: Nature Cancer
https://read.qxmd.com/read/38428552/cdc42-activation-is-necessary-for-heterosynaptic-cooperation-and-competition
#40
JOURNAL ARTICLE
Mariana Nunes, Natália Madeira, Rosalina Fonseca
Synapses change their weights in response to neuronal activity and in turn, neuronal networks alter their response properties and ultimately allow the brain to store information as memories. As for memories, not all events are maintained over time. Maintenance of synaptic plasticity depends on the interplay between functional changes at synapses and the synthesis of plasticity-related proteins that are involved in stabilizing the initial functional changes. Different forms of synaptic plasticity coexist in time and across the neuronal dendritic area...
February 28, 2024: Molecular and Cellular Neurosciences
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