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https://www.readbyqxmd.com/read/29241193/comparative-analysis-on-low-and-standard-dose-regimes-of-alteplase-thrombolytic-therapy-for-acute-ischemic-stroke-efficacy-and-safety
#1
Guangjian Zhao, Tingfen Huang, Mei Zheng, Yansen Cui, Yunyong Liu, Zhongrong Cheng, Ziran Wang
OBJECTIVE: This study analyzed the efficacy and safety of low-dose and standard-dose alteplase intravenous thrombolytic therapy for acute ischemic stroke (AIS). METHODS: Patients with AIS who underwent intravenous alteplase thrombolysis from July 2012 to December 2016 were retrospectively analyzed and correspondingly divided into low-dose (0.6-0.89 mg/kg) group and standard-dose group (0.9 mg/kg) according to alteplase dosage. The clinical outcome was evaluated by modified Rankin Scale (mRS) at 90 days after onset...
December 14, 2017: European Neurology
https://www.readbyqxmd.com/read/29241068/long-term-projections-of-temperature-related-mortality-risks-for-ischemic-stroke-hemorrhagic-stroke-and-acute-ischemic-heart-disease-under-changing-climate-in-beijing-china
#2
Tiantian Li, Radley M Horton, Daniel A Bader, Fangchao Liu, Qinghua Sun, Patrick L Kinney
BACKGROUND: Changing climates have been causing variations in the number of global ischemic heart disease and stroke incidences, and will continue to affect disease occurrence in the future. OBJECTIVES: To project temperature-related mortality for acute ischemic heart disease, and ischemic and hemorrhagic stroke with concomitant climate warming. METHODS: We estimated the exposure-response relationship between daily cause-specific mortality and daily mean temperature in Beijing...
December 11, 2017: Environment International
https://www.readbyqxmd.com/read/29240651/acute-impact-of-different-exercise-modalities-on-arterial-and-platelet-function
#3
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, P Hugh R Barrett, Louise H Naylor, Daniel J Green
PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29240566/a-practical-clinical-approach-to-utilize-cardiopulmonary-exercise-testing-in-the-evaluation-and-management-of-coronary-artery-disease-a-primer-for-cardiologists
#4
Sundeep Chaudhry, Ross Arena, Deepak L Bhatt, Subodh Verma, Naresh Kumar
PURPOSE OF REVIEW: There is growing clinical interest for the use of cardiopulmonary exercise testing (CPET) to evaluate patients with or suspected coronary artery disease (CAD). With mounting evidence, this concise review with relevant teaching cases helps to illustrate how to integrate CPET data into real world patient care. RECENT FINDINGS: CPET provides a novel and purely physiological basis to identify cardiac dysfunction in symptomatic patients with both obstructive-CAD and nonobstructive-CAD (NO-CAD)...
December 13, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29240016/drainage-of-cerebrospinal-fluid-and-blood-pressure-augmentation-as-rescue-therapies-for-ischemic-myelitis-after-bronchial-embolization-a-case-report
#5
Pierre-Alexis Lépine, Jean-François Naud, Philippe Boisvert
A 62-year-old man presented to the emergency department with massive hemoptysis. After bronchial artery embolization, he developed ischemic myelitis, a rare complication in this setting for which no specific therapy is currently recommended. The symptoms were managed with lumbar drainage of cerebrospinal fluid and blood pressure augmentation therapy. To our knowledge, this is the first report of using lumbar drainage of cerebrospinal fluid and blood pressure augmentation in the treatment of anterior medullary ischemia after bronchial artery embolization for massive hemoptysis...
December 11, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29239808/drug-class-renal-elimination-and-outcomes-of-direct-oral-anticoagulants-in-asian-patients-a-meta-analysis
#6
Kang-Ling Wang, Chun-Chih Chiu, Robert P Giugliano, Doreen Su-Yin Tan, Chun-Yi Lin, En-Yu Lai, Shinya Goto, Chern-En Chiang
BACKGROUND: Direct oral anticoagulants (DOACs) have a better risk benefit profile in Asian patients with atrial fibrillation (AF). Whether treatment effects could be modified by drug class and dependency on renal elimination of studied agents has not yet been explored. METHODS: We searched PubMed, CENTRAL, and CINAHL databases through November 2016 for phase III randomized controlled trials comparing DOACs with warfarin in patients with AF. Efficacy and safety outcomes were pooled according to drug class and dependency on renal elimination of DOACs and were compared with the Mantel-Haenszel fixed-effects model...
November 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29239807/an-objective-measurement-of-lacunar-infarct-location-from-the-middle-cerebral-artery-stem
#7
Shanal S Kumar, Bradford A Moffat, Simon Salinas, Leonid Churilov, Bernard Yan
BACKGROUND: There is emerging interest in the relationship between neuroimaging location of lacunar infarcts and underlying stroke risk factors. Recent methods used for localization of lacunar infarcts are affected by high inter-rater variability. We used a novel algorithm-driven method that provided quantitative assessment of the distance of the lacunar infarct from the origins of the lenticulostriate arteries. METHODS: We conducted a retrospective analysis of patients who presented with lacunar infarcts between 2007 and 2011...
November 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29239459/ischemic-left-ventricle-systolic-dysfunction-an-evidence-based-approach-in-diagnostic-tools-and-therapeutics
#8
Eduardo Gomes Lima, Felipe Pereira Câmara de Carvalho, Jaime Paula Pessoa Linhares Filho, Fabio Grunspun Pitta, Carlos Vicente Serrano
Coronary artery disease (CAD) associated with left ventricular systolic dysfunction is a condition related to poor prognosis. There is a lack of robust evidence in many aspects related to this condition, from definition to treatment. Ischemic cardiomyopathy is a spectrum ranging from stunned myocardium associated with myocardial fibrosis to hibernating myocardium and repetitive episodes of ischemia. In clinical practice, relevance lies in identifying the myocardium that has the ability to recover its contractile reserve after revascularization...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29239349/influences-of-ivabradine-treatment-on-serum-levels-of-cardiac-biomarkers-sst2-gdf-15-supar-and-h-fabp-in-patients-with-chronic-heart-failure
#9
Peter Jirak, Dzeneta Fejzic, Vera Paar, Bernhard Wernly, Rudin Pistulli, Ilonka Rohm, Christian Jung, Uta C Hoppe, P Christian Schulze, Michael Lichtenauer, Atilla Yilmaz, Daniel Kretzschmar
Chronic heart failure (CHF) represents a major cause of hospitalization and death. Recent evidence shows that novel biomarkers such as soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR) and heart-type fatty acid binding protein (H-FABP) are correlated with inflammatory and ischemic responses in CHF patients. In this study we examined the effects of Ivabradine that inhibited the hyperpolarization-activated cyclic nucleotide-gated channel (HCN channel, also called funny current If), thereby leading to selective heart rate reduction and improved myocardial oxygen supply on the cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in 50 CHF patients at the University Hospital of Jena...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239338/effects-of-neuregulin-1-on-autonomic-nervous-system-remodeling-post-myocardial-infarction-in-a-rat-model
#10
Xin Lai, Liang Zhong, Hai-Xia Fu, Song Dang, Xin Wang, Ning Zhang, Gao-Ke Feng, Zi-Qiang Liu, Xi Wang, Long Wang
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction (MI). Increasing evidence indicates that neuregulin-1 (NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham (with the left anterior descending coronary artery exposed but without ligation), MI (left anterior descending coronary artery ligation), and MI plus NRG-1 (left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1 (10 μg/kg, once daily for 7 days))...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239331/ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-are-risk-factors-for-ischemic-stroke-in-patients-with-type-2-diabetes
#11
Ting Li, Xiu-Juan Wu, Xiao-Min Chen, Si-Bo Wang, Kang-Ding Liu, Ying-Qi Xing
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity (BaPWV) and ankle-brachial index (ABI) are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group (n = 55) and a diabetes and ischemic stroke group (n = 62)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239311/interferon-regulatory-factor-2-binding-protein-2-a-new-player-of-the-innate-immune-response-for-stroke-recovery
#12
REVIEW
Hsiao-Huei Chen, Alexandre F R Stewart
Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused synapses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239134/recent-advances-in-managing-atherosclerosis-via-nanomedicine
#13
REVIEW
Cecilia Ka Wing Chan, Lei Zhang, Chak Kwong Cheng, Hongrong Yang, Yu Huang, Xiao Yu Tian, Chung Hang Jonathan Choi
Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with high mortality rates globally, such as stroke and ischemic heart disease. Engineered bio-nanomaterials are now under active investigation as carriers of therapeutic and/or imaging agents to atherosclerotic plaques. This Review summarizes the latest bio-nanomaterial-based strategies for managing atherosclerosis published over the past five years, a period marked by a rapid surge in preclinical applications of bio-nanomaterials for imaging and/or treating atherosclerosis...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238659/the-use-of-penile-prostheses-in-the-management-of-priapism
#14
REVIEW
Jonathan Moore, Thomas F Whelan, Gavin M Langille
Priapism is a relatively uncommon condition that can result in erectile dysfunction (ED) and corporal fibrosis. Cases of prolonged priapism are particularly prone to ED, which arises when priapism is treatment refractory or had a delayed presentation. Due to the emergent nature of priapism, it behooves urologists to be familiar with all potential treatment modalities to minimize adverse outcomes. In this review paper, we aim to summarize the literature regarding the use of penile prosthesis (PP) implantation in the setting of ischemic priapism (IP)...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238626/c-kit-positive-cardiac-outgrowth-cells-demonstrate-better-ability-for-cardiac-recovery-against-ischemic-myopathy
#15
Chuan Li, Satoshi Matsushita, Zhengqing Li, Jianjun Guan, Atsushi Amano
Objective: Resident cardiac stem cells are expected to be a therapeutic option for patients who suffer from severe heart failure. However, uncertainty remains over whether sorting cells for c-kit, a stem cell marker, improves therapeutic outcomes. Materials and methods: Cardiac outgrowth cells cultured from explants of rat heart atrium were sorted according to their positivity (+) or negativity (-) for c-kit. These cells were exposed to hypoxia for 3 d, and subsequently harvested for mRNA expression measurement...
October 2017: Journal of Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29238517/exogenous-h2s-restores-ischemic-post-conditioning-induced-cardioprotection-through-inhibiting-endoplasmic-reticulum-stress-in-the-aged-cardiomyocytes
#16
Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li, Changqing Xu
Background: A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in the aged hearts. Exogenous H2S restores PC-induced cardioprotection by inhibition of mitochondrial permeability transition pore opening and oxidative stress and increase of autophagy in the aged hearts. However, whether H2S contributes to the recovery of PC-induced cardioprotection via down-regulation of endoplasmic reticulum stress (ERS) in the aged hearts is unclear...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29238500/effects-of-dexmedetomidine-on-heart-arrhythmia-prevention-in-off-pump-coronary-artery-bypass-surgery-a-randomized-clinical-trial
#17
Ghasem Soltani, Saeed Jahanbakhsh, Mohammad Abbasi Tashnizi, Mehdi Fathi, Shahram Amini, Nahid Zirak, Shima Sheybani
Background: Arrhythmia occurring during and after surgery is one of the major complications in open-heart surgery. Dexmedetomidine is an intravenous alpha-2 agonist and very specific short-acting drug to protect the various organs against ischemic injuries and blood reflow. However, the effect of dexmedetomidine for preventing intraoperative heart arrhythmias has not been recognized. Objective: This study aimed to determine the effect of dexmedetomidine on the incidence rate of heart arrhythmias and anesthetic required in off-pump coronary artery bypass surgery...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238484/pattern-and-factors-associated-with-cardiovascular-diseases-among-patients-attending-the-cardiac-center-in-arar-city-northern-saudi-arabia
#18
Fatimah Fahad Altaleb, Othman Mashfi Alshammari, Hala Mohammed Alanazi, Dina Anwar Aljaber, Arwa Bader Alanazi, Nagah Mohamed Abo El-Fetoh, Nesreen Ali Mohammed, Hadil Anwar Aljaber
Background: Cardiovascular diseases (CVD) are among the main causes of premature death and hospital admission worldwide, constituting a great economic burden on health care systems. Additionally, thyroid diseases may exert a deleterious effect on the outcomes of CVD patients. Aim: This study was conducted to identify the pattern and factors associated with CVD distribution and the relation with thyroid dysfunction in the study population. Methods: This cross sectional study was conducted on 181 participants in the cardiac center in Arar, Kingdom of Saudi Arabia (KSA), from September 2016 to March 2017...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238467/neuroprotection-of-a-sesamin-derivative-1-2-bis-3-methoxyphenyl-methyl-ethane-1-2-dicaroxylic-acid-mmeda-against-ischemic-and-hypoxic-neuronal-injury
#19
Chang-Tsen Hung, Li-Dian Chen, Chien-Wei Hou
Objectives: Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis [(3-methoxyphenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The infaction of Sprague Dawley (SD) rats and hypoxia models of BV-2 microglia or PC12 cells were investigated for in vivo and in vitro test respectively...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238393/influence-of-severe-carotid-stenosis-on-cognition-depressive-symptoms-and-quality-of-life
#20
Elina Pucite, Ildze Krievina, Evija Miglane, Renars Erts, Dainis Krievins
Background: Carotid artery disease is not just a causal risk factor of ischemic stroke, but may predispose patients to depressive symptoms and low health related quality of life (HRQoL). Objectives: The objectives of the present study were to assess the association between severe carotid artery stenosis (CAS) and cognitive impairment, frequency of depressive symptoms and status of HRQoL. Methods: Cross - sectional study involved 55 patients with severe CAS and 54 patients with lower extremity peripheral artery disease (PAD)...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
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