keyword
https://read.qxmd.com/read/38100962/fetal-endothelial-colony-forming-cells-possible-targets-for-prevention-of-the-fetal-origins-of-adult-diseases
#21
REVIEW
Jing Jia, Baitao Ma, Xianlan Zhao
Endothelial colony-forming cells (ECFCs), a subset of circulating and resident endothelial progenitor cells, are capable of self-renewal and de novo vessel formation, and are known key regulators of vascular integrity and homeostasis. Numerous studies have found that exposure to hostile environment during the fetal development exerts a profound influence on the level and function of ECFCs, which may be the underlying factor linking endothelial dysfunction to cardiovascular disease of the offspring in later life...
December 10, 2023: Placenta
https://read.qxmd.com/read/38097030/fetal-fraction-of-cell-free-dna-in-non-invasive-prenatal-testing-and-adverse-pregnancy-outcomes-a-nationwide-retrospective-cohort-study-of-56-110-pregnant-women
#22
JOURNAL ARTICLE
Ellis C Becking, Peter G Scheffer, Jens Henrichs, Caroline J Bax, Neeltje Mth Crombag, Marjan M Weiss, Merryn Ve Macville, Diane van Opstal, Elles Mj Boon, Erik A Sistermans, Lidewij Henneman, Ewoud Schuit, Mireille N Bekker
BACKGROUND: Non-invasive prenatal testing by cell-free DNA analysis is offered to pregnant women worldwide to screen for fetal aneuploidies. In non-invasive prenatal testing, the fetal fraction of cell-free DNA in the maternal circulation is measured as a quality control parameter. Since fetal cell-free DNA originates from the placenta, the fetal fraction might also reflect placental health and maternal pregnancy adaptation. OBJECTIVE: To assess the association between the fetal fraction and adverse pregnancy outcomes...
December 12, 2023: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38090414/sars-cov-2-infection-in-the-second-trimester-of-pregnancy-a-case-report-of-fetal-intraventricular-hemorrhage-after-critical-covid-19-infection-and-a-brief-review-of-the-literature
#23
Antonella Vimercati, Rosalba De Nola, Miriam Dellino, Lorenzo Vinci, Ilaria Ricci, Antonio Malvasi, Gianluca Raffaello Damiani, Maria Gaetani, Bruno Lamanna, Ettore Cicinelli, Cecilia Salzillo, Andrea Marzullo, Leonardo Resta, Eliano Cascardi, Gerardo Cazzato
More than three and a half years have passed since the start of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there have been several studies in the literature about the different damage and symptom patterns related to the condition; particular attention has been paid to the transmission of the disease from pregnant mothers to fetus. In this report, we present the case of a 36-year-old patient with a history of two cesarean sections (CS), two miscarriages, and hypothyroidism on replacement therapy, who contracted COVID-19 during the 15th week of gestation...
November 2023: Curēus
https://read.qxmd.com/read/38039843/spiral-uterine-artery-doppler-and-placental-ultrasound-in-relation-to-preeclampsia
#24
REVIEW
Tania de Ganzo Suárez, Catalina de Paco Matallana, Walter Plasencia
Preeclampsia (PE) is a multiorgan disorder that complicates around 2-8% of pregnancies and is a major cause of perinatal and maternal morbidity and mortality. PE is a clinical syndrome characterized by hypertension secondary to systemic inflammation, endothelial dysfunction, and syncytiotrophoblast stress leading to hypertension and multiorgan dysfunction. The uterine arteries are the main blood vessels that supply blood to the uterus. They give off branches and plays an important role in maintaining blood supply during pregnancy...
November 28, 2023: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/38036237/lps-induced-inflammation-in-rats-during-pregnancy-reduces-maternal-melatonin-and-impairs-neurochemistry-and-behavior-of-adult-male-offspring
#25
JOURNAL ARTICLE
Caio Sérgio Galina Spilla, Ana Luiza Decanini Miranda de Souza, Leila Maria Guissoni Campos, Sanseray da Silveira Cruz-Machado, Luciana Pinato
Inflammation during pregnancy can induce neurodevelopmental changes that affect the neurological health of offspring. Elevated levels of circulating inflammatory cytokines have been shown to decrease nocturnal melatonin synthesis by the pineal gland, potentially impacting fetal development. This study aimed to assess the effects of LPS-induced inflammation on melatonin concentrations in the plasma of pregnant female rats and explore resulting neurochemical and behavioral changes in their offspring. Our findings revealed that pregnant rats injected with LPS experienced decreased nocturnal melatonin levels in their plasma, with an increase in diurnal melatonin content...
November 28, 2023: Brain Research
https://read.qxmd.com/read/38019395/assessment-of-placental-sodium-independent-leucine-uptake-and-transfer-in-trophoblast-cells
#26
JOURNAL ARTICLE
Jonas Zaugg, Christiane Albrecht
The placenta maintains the balance between nutrition and growth control of the fetus through selective and regulated supply of macronutrients such as carbohydrates, proteins, lipids, and critical micronutrients. Perturbations in the balanced supply of nutrients as found in gestational diseases and altered fetal development have been associated with changes in amino acid transport proteins, such as the System L amino acid heterodimeric exchangers LAT1/SLC7A5 and LAT2/SLC7A8. Syncytiotrophoblasts (STB) form the crucial cell layer at the placental barrier coordinating the transfer of essential amino acids such as leucine from the maternal to the fetal circulation...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38016336/topics-on-maternal-fetal-and-neonatal-immunology-of-dogs-and-cats
#27
REVIEW
Keylla Helena Nobre Pacífico Pereira, Kárita da Mata Fuchs, Júlia Cosenza Mendonça, Gleice Mendes Xavier, Fabíola Cardoso Knupp, Maria Lucia Gomes Lourenço
Birth and the first few weeks of age are critical periods of developing the immune system of puppies and kittens and adapting to an environment containing a variety of infectious agents. The survival rate during these periods depends mainly on the newborn's immune capacity to prevent and combat infections. Although most components of innate and adaptive immunity are present at birth, responses are slow and immature compared to adults. Due to immunological immaturity and the endotheliochorial placental structure, circulating concentrations of immunoglobulins in dogs and cats at birth are quite low...
November 21, 2023: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38009053/up-regulated-levels-of-shla-g-in-women-with-a-history-of-rpl-in-mid-gestation-presumably-to-achieve-ongoing-pregnancy
#28
JOURNAL ARTICLE
Parveen Jahan, Rashmi Bhuwalka, Mahmooda Begum, Dhatri Madduru, Arif Ahmad, Rajeshwari Bonu
PROBLEM: Recurrent Pregnancy Loss (RPL) is a disorder characterized by two or more pregnancy losses within 20th week of gestation. Globally 1-5% of the couples are affected, 50% of these cases are with unknown etiology. HLA-G, an Immuno-modulatory molecule is a non-classical MHC-1 protein, expressed abundantly on extravillous trophoblastic cells, responsible for spiral artery remodeling, maintaining maternal immune tolerance and fetal growth by adjusting pro and anti-inflammatory milieu during different gestational phases...
December 2023: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/37991978/reduced-endothelial-progenitor-cells-a-possible-biomarker-for-idiopathic-fetal-growth-restriction-in-human-pregnancies
#29
JOURNAL ARTICLE
Apurva Singh, Shyam Pyari Jaiswar, Apala Priyadarshini, Sujata Deo
BACKGROUND: Circulating endothelial progenitor cells (EPCs) may be necessary throughout pregnancy by ensuring proper placentation and embryonic growth. The lack of standardized EPC quantification techniques has prevented conclusive proof of an increase in EPC during pregnancy. OBJECTIVES: The purpose of this study was to determine whether EPC levels change for healthy and idiopathic fetal growth restriction (FGR) pregnancies. MATERIALS AND METHODS: The study population consisted of 48 healthy pregnant females with no previous history of IUGR (10 in the first trimester, 15 in the second, and 23 in the third), 48 women with pregnancy complicated by idiopathic FGR, and 15 non-pregnant women...
June 1, 2023: Journal of mother and child
https://read.qxmd.com/read/37958809/mrna-and-protein-expression-in-human-fetal-membrane-cells-potential-biomarkers-for-preterm-prelabor-rupture-of-the-fetal-membranes
#30
JOURNAL ARTICLE
Emmeli Mikkelsen, Berthold Huppertz, Ripudaman Singh, Katarina Ravn, Lotte Hatt, Mogens Kruhøffer, Rheanna Urrabaz-Garza, Niels Uldbjerg, Ramkumar Menon, Torben Steiniche
Clinically, unique markers in fetal membrane cells may contribute to the search for biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood. pPROM is associated with overwhelming inflammation and premature cellular senescence causing "biological microfractures" of the fetal membranes. We hypothesize that these pathological processes are associated with the shedding of fetal membrane cells into the maternal circulation. The aim of this study was to identify markers expressed exclusively in fetal membrane cells to facilitate their isolation, characterization, and determination of biomarker potential in maternal blood...
October 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37930978/maternal-circulating-mirnas-contribute-to-negative-pregnancy-outcomes-by-altering-placental-transcriptome-and-fetal-vascular-dynamics
#31
JOURNAL ARTICLE
Marisa R Pinson, Alexander M Tseng, Tenley E Lehman, Karen Chung, Jessica Gutierrez, Kirill V Larin, Christina D Chambers, Rajesh C Miranda
Circulating miRNAs the in blood are promising biomarkers for predicting pregnancy complications and adverse birth outcomes. Previous work identified 11 gestationally elevated maternal circulating miRNAs (HEamiRNAs) that predicted infant growth deficits following prenatal alcohol exposure and regulated epithelial-mesenchymal transition in the placenta. Here we show that a single intravascular administration of pooled murine-conserved HEamiRNAs to pregnant mice on gestational day 10 (GD10) attenuates umbilical cord blood flow during gestation, explaining the observed intrauterine growth restriction (IUGR), specifically decreased fetal weight, and morphometric indices of cranial growth...
2023: PloS One
https://read.qxmd.com/read/37891883/maternal-supraphysiological-hypercholesterolemia-is-accompanied-by-shifts-in-the-composition-and-anti-atherogenic-functions-of-maternal-hdl-along-with-maternal-cardiovascular-risk-markers-at-term-of-pregnancy
#32
JOURNAL ARTICLE
Claudette Cantin, Andrea Morales, Ramón Serra, Sebastián E Illanes, Andrea Leiva
BACKGROUND: Maternal physiological hypercholesterolemia (MPH) occurs in pregnancy for a proper fetal development. When cholesterol increases over the physiological range, maternal supraphysiological hypercholesterolemia (MSPH) is described, a condition underdiagnosed by a lack of evidence showing its biological and clinical relevance. AIM: To determine if MSPH associates with maternal vascular dysfunction, along with changes in the composition and function of maternal HDL leading to increased cardiovascular risk...
September 27, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37848604/alloimmune-hemolytic-disease-of-the-fetus-and-newborn-genetics-structure-and-function-of-the-commonly-involved-erythrocyte-antigens
#33
REVIEW
Robert D Christensen, Timothy M Bahr, Sarah J Ilstrup, Donna S Dizon-Townson
Hemolytic disease of the fetus and newborn (HDFN) can occur when a pregnant woman has antibody directed against an erythrocyte surface antigen expressed by her fetus. This alloimmune disorder is restricted to situations where transplacental transfer of maternal antibody to the fetus occurs, and binds to fetal erythrocytes, and significantly shortens the red cell lifespan. The pathogenesis of HDFN involves maternal sensitization to erythrocyte "non-self" antigens (those she does not express). Exposure of a woman to a non-self-erythrocyte antigen principally occurs through either a blood transfusion or a pregnancy where paternally derived erythrocyte antigens, expressed by her fetus, enter her circulation, and are immunologically recognized as foreign...
December 2023: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/37842488/the-anaphylactoid-syndrome-of-pregnancy-two-autopsy-cases
#34
Ioannis Plantzas, Athina Tousia, Dimitrios Vlachodimitropoulos, Maria Piagkou, Nikolaos Goutas, George Tsakotos, George Triantafyllou, Evangelos Plantzas, Emmanouil Sakelliadis
The anaphylactoid syndrome of pregnancy (ASP) is a rare emergency with significant mortality and morbidity, in which the amniotic fluid and fetal cells enter the maternal circulation leading to respiratory failure, altered mental status, hypotension, and disseminated intravascular coagulation. The term ASP was recently introduced to replace the term amniotic fluid embolism since the clinical manifestations of the entity were more similar to a septic or anaphylactic shock rather than that of an embolic event...
September 2023: Curēus
https://read.qxmd.com/read/37829603/reversal-of-maternal-obesity-attenuates-hypoxia-and-improves-placental-development-in-the-preeclamptic-like-bph-5-mouse-model
#35
JOURNAL ARTICLE
Daniella M Adams, Kalie F Beckers, Juliet P Flanagan, Viviane C L Gomes, Chin-Chi Liu, Jenny L Sones
BACKGROUND: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface...
September 28, 2023: Biocell: Official Journal of the Sociedades Latinoamericanas de Microscopía Electronica ... Et. Al
https://read.qxmd.com/read/37829280/clinical-interpretation-of-cell-based-non-invasive-prenatal-testing-for-monogenic-disorders-including-repeat-expansion-disorders-potentials-and-pitfalls
#36
JOURNAL ARTICLE
Line Dahl Jeppesen, Lotte Hatt, Ripudaman Singh, Palle Schelde, Katarina Ravn, Christian Liebst Toft, Maria Bach Laursen, Jakob Hedegaard, Inga Baasch Christensen, Bolette Hestbek Nicolaisen, Lotte Andreasen, Lars Henning Pedersen, Ida Vogel, Dorte Launholt Lildballe
Introduction: Circulating fetal cells isolated from maternal blood can be used for prenatal testing, representing a safe alternative to invasive testing. The present study investigated the potential of cell-based noninvasive prenatal testing (NIPT) for diagnosing monogenic disorders dependent on the mode of inheritance. Methods: Maternal blood samples were collected from women opting for prenatal diagnostics for specific monogenic disorders ( N = 7). Fetal trophoblasts were enriched and stained using magnetic activated cell sorting and isolated by fluorescens activated single-cell sorting...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37822034/exploring-factors-impacting-haplotype-based-noninvasive-prenatal-diagnosis-for-single-gene-recessive-disorders
#37
JOURNAL ARTICLE
Lingrong Kong, Shaojun Li, Zhenhua Zhao, Jun Feng, Xinyu Fu, Huanyun Li, Jingqi Zhu, Yanan Wang, Weiqin Tang, Chao Yuan, Feifei Li, Xiujuan Han, Di Wu, Xiangdong Kong, Luming Sun
Haplotype-based noninvasive prenatal diagnosis (NIPD) is applicable for various recessive single-gene disorders in proband families. However, a comprehensive exploration of critical factors influencing the assay performance, such as fetal fraction, informative single nucleotide polymorphism (SNP) count, and recombination events, has yet to be performed. It is critical to identify key factors affecting NIPD performance, including its accuracy and success rate, and their impact on clinical diagnostics to guide clinical practice...
October 11, 2023: Clinical Genetics
https://read.qxmd.com/read/37801498/the-maternal-microbiome-promotes-placental-development-in-mice
#38
JOURNAL ARTICLE
Geoffrey N Pronovost, Kristie B Yu, Elena J L Coley-O'Rourke, Sahil S Telang, Angela S Chen, Helen E Vuong, Drake W Williams, Anisha Chandra, Tomiko K Rendon, Jorge Paramo, Reuben H Kim, Elaine Y Hsiao
The maternal microbiome is an important regulator of gestational health, but how it affects the placenta as the interface between mother and fetus remains unexplored. Here, we show that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricts placental growth and impairs feto-placental vascularization. The maternal gut microbiota modulates metabolites in the maternal and fetal circulation. Short-chain fatty acids (SCFAs) stimulate cultured endothelial cell tube formation and prevent abnormalities in placental vascularization in microbiota-deficient mice...
October 6, 2023: Science Advances
https://read.qxmd.com/read/37788576/maternal-nutrient-restriction-during-late-gestation-reduces-vigor-and-alters-blood-chemistry-and-hematology-in-neonatal-beef-calves
#39
JOURNAL ARTICLE
Lindsey G Wichman, Colby A Redifer, Allison M Meyer
Fall-calving primiparous beef females [body weight: 451 ± 28 (SD) kg; body condition score: 5.4 ± 0.7] were individually-fed either 100% (control; CON; n = 13) or 70% (nutrient restricted; NR; n = 13) of metabolizable energy and metabolizable protein requirements for maintenance, pregnancy, and growth from day 160 of gestation to parturition. Calves were reared naturally by their dams and monitored for latency times from birth to first sternal recumbency, attempt to stand, and stand; vigor scores were assigned at 2, 5, 10, and 20 min of age...
October 3, 2023: Journal of Animal Science
https://read.qxmd.com/read/37750879/induced-abortion-and-the-risk-of-rh-sensitization
#40
MULTICENTER STUDY
Sarah Horvath, Zhen-Yu Huang, Nathanael C Koelper, Christian Martinez, Patricia Y Tsao, Ling Zhao, Alisa B Goldberg, Curtiss Hannum, Mary E Putt, Eline T Luning Prak, Courtney A Schreiber
IMPORTANCE: While population-level data suggest Rh immunoglobulin is unnecessary before 12 weeks' gestation, clinical evidence is limited. Thus, guidelines vary, creating confusion surrounding risks and benefits of Rh testing and treatment. As abortion care in traditional clinical settings becomes harder to access, many people are choosing to self-manage and need to know if ancillary blood type testing is necessary. OBJECTIVE: To determine how frequently maternal exposure to fetal red blood cells (fRBCs) exceeds the most conservative published threshold for Rh sensitization in induced first-trimester abortion...
September 26, 2023: JAMA
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