Valeria Garcia-Flores, Roberto Romero, Adi L Tarca, Azam Peyvandipour, Yi Xu, Jose Galaz, Derek Miller, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Stanley M Berry, Awoniyi O Awonuga, David R Bryant, Roger Pique-Regi, Nardhy Gomez-Lopez
Labor is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. However, the cellular contributions and communications that facilitate maternal-fetal cross-talk in labor have not been fully elucidated. Here, single-cell RNA sequencing (scRNA-seq) was applied to decipher maternal-fetal signaling in the human placenta during term labor. First, a single-cell atlas of the human placenta was established, demonstrating that maternal and fetal cell types underwent changes in transcriptomic activity during labor...
January 10, 2024: Science Translational Medicine