keyword
https://read.qxmd.com/read/38474355/the-impact-of-slc2a8-rna-interference-on-glucose-uptake-and-the-transcriptome-of-human-trophoblast-cells
#1
JOURNAL ARTICLE
Aleksandra Lipka, Łukasz Paukszto, Victoria C Kennedy, Amelia R Tanner, Marta Majewska, Russell V Anthony
While glucose is the primary fuel for fetal growth, the placenta utilizes the majority of glucose taken up from the maternal circulation. Of the facilitative glucose transporters in the placenta, SLC2A8 (GLUT8) is thought to primarily function as an intracellular glucose transporter; however, its function in trophoblast cells has not been determined. To gain insight into the function of SLC2A8 in the placenta, lentiviral-mediated RNA interference (RNAi) was performed in the human first-trimester trophoblast cell line ACH-3P...
February 24, 2024: Cells
https://read.qxmd.com/read/38458919/ifpa-joan-hunt-senior-award-in-placentology-lecture-extracellular-vesicle-signalling-and-pregnancy
#2
JOURNAL ARTICLE
Gregory E Rice, Carlos Salomon
The field of extracellular vesicle (EV) signalling has the potential to transform our understanding of maternal-fetal communication and affords new opportunities for non-invasive prenatal testing and therapeutic intervention. EVs have been implicated in implantation, placentation, maternal adaptation to pregnancy and complications of pregnancy, being detectable in maternal circulation as early as 6 weeks of pregnancy. EVs of differing biogenic origin, composition and bioactivity are released by cells to maintain homoeostasis...
February 23, 2024: Placenta
https://read.qxmd.com/read/38452118/insights-into-non-informative-results-from-non-invasive-prenatal-screening-through-gestational-age-maternal-bmi-and-age-analyses
#3
JOURNAL ARTICLE
Juraj Gazdarica, Natalia Forgacova, Tomas Sladecek, Marcel Kucharik, Jaroslav Budis, Michaela Hyblova, Martina Sekelska, Andrej Gnip, Gabriel Minarik, Tomas Szemes
The discovery of cell-free fetal DNA fragments in the maternal plasma initiated a novel testing method in prenatal care, called non-invasive prenatal screening (NIPS). One of the limitations of NIPS is the necessity for a sufficient proportion of fetal fragments in the analyzed circulating DNA mixture (fetal fraction), otherwise, the sample is uninterpretable. We present the effect of gestational age, maternal body mass index (BMI), and maternal age on the fetal fraction (FF) of the sample. We retrospectively analyzed data from 5543 pregnant women with a single male fetus who underwent NIPS from which 189 samples received a repeat testing due to an insufficient FF...
2024: PloS One
https://read.qxmd.com/read/38428650/the-chemokine-xcl1-functions-as-a-pregnancy-hormone-to-program-offspring-innate-anxiety
#4
JOURNAL ARTICLE
Rosa J Chen, Anika Nabila, Judit Gal Toth, Heidi Stuhlmann, Miklos Toth
Elevated levels of cytokines in maternal circulation increase the offspring's risk for neuropsychiatric disease. Because of their low homeostatic levels, circulating maternal cytokines during normal pregnancies have not been considered to play a role in fetal brain development and offspring behavior. Here we report that the T/NK cell chemotactic cytokine XCL1, a local paracrine immune signal, can function as a pregnancy hormone and is required for the proper development of placenta and male offspring approach-avoidance behavior...
February 28, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38420039/the-role-of-the-placenta-brain-axis-in-psychoneuroimmune-programming
#5
JOURNAL ARTICLE
Serena B Gumusoglu
Gestational exposures have enduring impacts on brain and neuroimmune development and function. Perturbations of pregnancy leading to placental structure/function deficits, cell stress, immune activation, and endocrine changes (metabolic, growth factors, etc.) all increase neuropsychiatric risk in offspring. The existing literature links obstetric diseases with placental involvement to offspring neuroimmune outcomes and neurodevelopmental risk. Psychoneuroimmune outcomes in offspring brain include changes to microglia, cytokine/chemokine production, cell stress, and long-term immunoreactivity...
March 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38363211/il-33-supplementation-improves-uterine-artery-resistance-and-maternal-hypertension-in-response-to-placental-ischemia
#6
JOURNAL ARTICLE
Xi Wang, Corbin Shields, Geilda Tardo, Gregory Peacock, Emily Hester, Marissa Anderson, Jan M Williams, Denise Cornelius
Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a hypertensive pregnancy disorder with end-organ damage that manifests after 20 weeks of gestation. PE is characterized by chronic immune activation and endothelial dysfunction. Clinical studies report reduced IL-33 signaling in PE. We use the <u>R</u>educed <u>U</u>terine <u>P</u>erfusion <u>P</u>ressure (RUPP) rat model, which mimics many PE characteristics including reduced IL-33, to identify mechanisms mediating PE pathophysiology...
February 16, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38362745/differential-5-trna-fragment-expression-in-circulating-preeclampsia-syncytiotrophoblast-vesicles-drives-macrophage-inflammation
#7
JOURNAL ARTICLE
William Robert Cooke, Peiyong Jiang, Lu Ji, Jinyue Bai, Gabriel Davis Jones, Y M Dennis Lo, Christopher Redman, Manu Vatish
BACKGROUND: The relationship between placental pathology and the maternal syndrome of preeclampsia is incompletely characterized. Mismatch between placental nutrient supply and fetal demands induces stress in the syncytiotrophoblast, the layer of placenta in direct contact with maternal blood. Such stress alters the content and increases the release of syncytiotrophoblast extracellular vesicles (STB-EVs) into the maternal circulation. We have previously shown 5'-tRNA fragments (5'-tRFs) constitute the majority of small RNA in STB-EVs in healthy pregnancy...
February 16, 2024: Hypertension
https://read.qxmd.com/read/38359068/are-fetal-microchimerism-and-circulating-fetal-extracellular-vesicles-important-links-between-spontaneous-preterm-delivery-and-maternal-cardiovascular-disease-risk
#8
JOURNAL ARTICLE
Elizabeth A Bonney, Ryan C V Lintao, Carolyn M Zelop, Ananth Kumar Kammala, Ramkumar Menon
Trafficking and persistence of fetal microchimeric cells (fMCs) and circulating extracellular vesicles (EVs) have been observed in animals and humans, but their consequences in the maternal body and their mechanistic contributions to maternal physiology and pathophysiology are not yet fully defined. Fetal cells and EVs may help remodel maternal organs after pregnancy-associated changes, but the cell types and EV cargos reaching the mother in preterm pregnancies after exposure to various risk factors can be distinct from term pregnancies...
February 15, 2024: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/38353227/at1-aa-is-produced-in-offspring-in-response-to-placental-ischemia-and-is-lowered-by-b-cell-depletion-without-compromising-overall-offspring-health
#9
JOURNAL ARTICLE
Nathan Campbell, Evangeline Deer, Dylan Solise, Denise C Cornelius, Ty Turner, Lorena M Amaral, Owen Herrock, Ariel Jordan, Shivani Shukla, Tarek Ibrahim, Babbette LaMarca
BACKGROUND: Preeclampsia, new-onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby. Low birth weight contributes to high risk of cardiovascular disorders later in life. Women with preeclampsia have activated B cells producing agonistic autoantibodies to AT1-AA (angiotensin II type I receptor). We hypothesize that rituximab, a B cell-depleting chemotherapeutic, will deplete maternal B cells in reduced uterine perfusion pressure (RUPP) rats without worsening the effect of placental ischemia on pup growth and survival...
February 14, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38314803/the-differential-regulation-of-placenta-trophoblast-bisphosphoglycerate-mutase-in-fetal-growth-restriction-preclinical-study-in-mice-and-observational-histological-study-of-human-placenta
#10
JOURNAL ARTICLE
Sima Stroganov, Talia Harris, Liat Fellus-Alyagor, Lital Ben Moyal, Romina Plitman Mayo, Ofra Golani, Dana Hirsch, Shifra Ben-Dor, Alexander Brandis, Tevie Mehlman, Michal Kovo, Tal Biron-Shental, Nava Dekel, Michal Neeman
Background: Fetal growth restriction (FGR) is a pregnancy complication in which a newborn fails to achieve its growth potential, increasing the risk of perinatal morbidity and mortality. Chronic maternal gestational hypoxia, as well as placental insufficiency are associated with increased FGR incidence; however, the molecular mechanisms underlying FGR remain unknown. Methods: Pregnant mice were subjected to acute or chronic hypoxia (12.5% O2 ) resulting in reduced fetal weight. Placenta oxygen transport was assessed by blood oxygenation level dependent (BOLD) contrast magnetic resonance imaging (MRI)...
February 5, 2024: ELife
https://read.qxmd.com/read/38309014/fetal-origin-cells-in-maternal-circulation-correlate-with-placental-dysfunction-fetal-sex-and-severe-hypertension-during-pregnancy
#11
JOURNAL ARTICLE
Heidi E Fjeldstad, Daniel P Jacobsen, Guro M Johnsen, Meryam Sugulle, Angel Chae, Sami B Kanaan, Hilary S Gammill, Anne Cathrine Staff
Fetal microchimerism (FMc) arises when fetal cells enter maternal circulation, potentially persisting for decades. Increased FMc is associated with fetal growth restriction, preeclampsia, and anti-angiogenic shift in placenta-associated proteins in diabetic and normotensive term pregnancies. The two-stage model of preeclampsia postulates that placental dysfunction causes such shift in placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFLt-1), triggering maternal vascular inflammation and endothelial dysfunction...
January 20, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38282604/progesterone-induced-blocking-factor-blockade-causes-hypertension-in-pregnant-rats
#12
JOURNAL ARTICLE
Alexis Meadors, Kyleigh Comley, Jesse N Cottrell, Tarek Ibhahim, Mark W Cunningham, Lorena M Amaral
Preeclampsia (PE) is a multisystem disorder characterized by new onset hypertension in mid-late gestation and can include multi-organ dysfunction with or without proteinuria. It affects 5%-7% of all pregnancies in the U.S., making PE a major contributor to maternal and fetal morbidity and mortality. Currently, there is no cure for this pregnancy complication except for early delivery of the placenta and fetus. Moreover, the therapeutic options to treat PE are very limited. One potential trigger for the development of PE is progesterone deficiency-induced imbalance between T Helper 1(Th1)/Th2 cells, an increase in cytolytic natural killer (NK) cells and inflammatory cytokines that in turn leads to endothelial dysfunction, intrauterine growth restriction (IUGR) and hypertension...
January 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38263146/fibronectin-mediates-activin-a-promoted-human-trophoblast-migration-and-acquisition-of-endothelial-like-phenotype
#13
JOURNAL ARTICLE
Xiangxin Lan, Ling Guo, Cuiping Hu, Qian Zhang, Jianye Deng, Yufeng Wang, Zi-Jiang Chen, Junhao Yan, Yan Li
BACKGROUND: During human early placentation, a proportion of extravillous trophoblasts (EVTs) migrate to the maternal decidua, differentiating into endovascular EVTs to remodel spiral arteries and ensure the establishment of blood circulation at the maternal-fetal interface. Inadequate EVT migration and endovascular differentiation are closely associated with adverse pregnancy outcomes such as miscarriage. Activin A and fibronectin are both secretory molecules abundantly expressed at the maternal-fetal interface...
January 23, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38223199/oleic-acid-stimulation-of-amino-acid-uptake-in-primary-human-trophoblast-cells-is-mediated-by-phosphatidic-acid-and-mtor-signaling
#14
JOURNAL ARTICLE
Elena Silva, Véronique Ferchaud-Roucher, Anita Kramer, Lana Madi, Priyadarshini Pantham, Stephanie Chassen, Thomas Jansson, Theresa L Powell
Normal fetal development is critically dependent on optimal nutrient supply by the placenta, and placental amino acid transport has been demonstrated to be positively associated with fetal growth. Mechanistic target of rapamycin (mTOR) is a positive regulator of placental amino acid transporters, such as System A. Oleic acid (OA) has been previously shown to have a stimulatory role on placental mTOR signaling and System A amino acid uptake in primary human trophoblast (PHT) cells. We investigated the mechanistic link between OA and System A activity in PHT...
January 2024: FASEB BioAdvances
https://read.qxmd.com/read/38201292/crossing-the-barrier-a-comparative-study-of-listeria-monocytogenes-and-treponema-pallidum-in-placental-invasion
#15
REVIEW
Samuel J Eallonardo, Nancy E Freitag
Vertically transmitted infections are a significant cause of fetal morbidity and mortality during pregnancy and pose substantial risks to fetal development. These infections are primarily transmitted to the fetus through two routes: (1) direct invasion and crossing the placenta which separates maternal and fetal circulation, or (2) ascending the maternal genitourinary tact and entering the uterus. Only two bacterial species are commonly found to cross the placenta and infect the fetus: Listeria monocytogenes and Treponema pallidum subsp...
December 31, 2023: Cells
https://read.qxmd.com/read/38198568/deciphering-maternal-fetal-cross-talk-in-the-human-placenta-during-parturition-using-single-cell-rna-sequencing
#16
JOURNAL ARTICLE
Valeria Garcia-Flores, Roberto Romero, Adi L Tarca, Azam Peyvandipour, Yi Xu, Jose Galaz, Derek Miller, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Stanley M Berry, Awoniyi O Awonuga, David R Bryant, Roger Pique-Regi, Nardhy Gomez-Lopez
Labor is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. However, the cellular contributions and communications that facilitate maternal-fetal cross-talk in labor have not been fully elucidated. Here, single-cell RNA sequencing (scRNA-seq) was applied to decipher maternal-fetal signaling in the human placenta during term labor. First, a single-cell atlas of the human placenta was established, demonstrating that maternal and fetal cell types underwent changes in transcriptomic activity during labor...
January 10, 2024: Science Translational Medicine
https://read.qxmd.com/read/38197791/maternal-glp-1-receptor-activation-inhibits-fetal-growth
#17
JOURNAL ARTICLE
Liping Qiao, Cindy Lu, Tianyi Zang, Brianna Dzyuba, Jianhua Shao
Glucagon-like peptide 1 (GLP-1) regulates food intake, insulin production, and metabolism. Our recent studydemonstrated that pancreatic α-cells-secreted (intraislet) GLP-1 effectively promotes maternal insulin secretion and metabolic adaptation during pregnancy. However, the role of circulating GLP-1 in maternal energy metabolism remains largely unknown. Our study aims to investigate systemic GLP-1 response to pregnancy and its regulatory effect on fetal growth. Employing C57BL/6 mice, we observed a gradual decline in maternal blood GLP-1 concentrations...
January 10, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38190129/suppression-of-progesterone-by-influenza-a-virus-mediates-adverse-maternal-and-fetal-outcomes-in-mice
#18
JOURNAL ARTICLE
Patrick S Creisher, Maclaine A Parish, Jun Lei, Jin Liu, Jamie L Perry, Ariana D Campbell, Morgan L Sherer, Irina Burd, Sabra L Klein
Pregnant individuals are at risk of severe outcomes from both seasonal and pandemic influenza A viruses. Influenza infection during pregnancy is associated with adverse fetal outcomes at birth and adverse consequences for offspring into adulthood. When outbred dams, with semi-allogenic fetuses, were infected with 2009 H1N1, in addition to pulmonary virus replication, lung damage, and inflammation, the placenta showed evidence of transient cell death and inflammation that was mediated by increased activity along the arachidonic acid pathway leading to suppression of circulating progesterone...
January 8, 2024: MBio
https://read.qxmd.com/read/38169218/transplacental-migration-of-maternal-natural-killer-and-t-cells-assessed-by-ex-vivo-human-placenta-perfusion
#19
JOURNAL ARTICLE
Diana M Morales-Prieto, Kathrin Wieditz, Juliane Götze, Jana Pastuschek, Maja Weber, Claudia Göhner, Tanja Groten, Udo R Markert
INTRODUCTION: The transplacental passage of cells between a mother and her fetus, known as microchimerism, is a less studied process during pregnancy. The frequency of maternal microchimeric cells in fetal tissues in physiological pregnancies and mechanisms responsible for transplacental cell trafficking are poorly understood. This study aimed to evaluate the placental trafficking of maternal peripheral blood mononuclear cells (PBMC) using human ex vivo placenta perfusion. METHODS: Ten placentas and maternal PBMC were obtained after healthy pregnancies...
December 20, 2023: Placenta
https://read.qxmd.com/read/38139126/the-role-of-the-fgf19-family-in-the-pathogenesis-of-gestational-diabetes-a-narrative-review
#20
REVIEW
Agata Sadowska, Elżbieta Poniedziałek-Czajkowska, Radzisław Mierzyński
Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Understanding the pathogenesis and appropriate diagnosis of GDM enables the implementation of early interventions during pregnancy that reduce the risk of maternal and fetal complications. At the same time, it provides opportunities to prevent diabetes, metabolic syndrome, and cardiovascular diseases in women with GDM and their offspring in the future. Fibroblast growth factors (FGFs) represent a heterogeneous family of signaling proteins which play a vital role in cell proliferation and differentiation, repair of damaged tissues, wound healing, angiogenesis, and mitogenesis and also affect the regulation of carbohydrate, lipid, and hormone metabolism...
December 9, 2023: International Journal of Molecular Sciences
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