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https://www.readbyqxmd.com/read/29648477/acute-intensive-care-unit-management-of-mustard-gas-victims-the-turkish-experience
#1
Ertugrul Kilic, Mesut Ortatatli, Sermet Sezigen, Rusen Koray Eyison, Levent Kenar
Sulfur mustard (SM) is an highly toxic and vesicant chemical weapon that was used in various military conflicts several times in the history. The severity of ocular, dermal, and pulmonary symptoms that may appear following a characteristic asymptomatic period are depending on the SM concentration and exposure duration. The aim of this study is to present the clinical features and share the intensive care unit (ICU) experiences for the medical management of mustard gas victims. Thirteen Free Syrian Army soldiers near Al-Bab region of North Syria were reportedly exposed to oily blackish smoke with garlic smell due to the explosion of a trapped bomb without causing any blast or thermal effect on 26th November 2016...
April 12, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29598830/the-putative-amino-acid-abc-transporter-substrate-binding-protein-aapj2-is-necessary-for-brucella-virulence-at-the-early-stage-of-infection-in-a-mouse-model
#2
Mingxing Tian, Yanqing Bao, Peng Li, Hai Hu, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Xiaolan Wang, Shengqing Yu
Brucellosis is a zoonotic bacterial disease caused by Brucella spp. The virulence of these bacteria is dependent on their ability to invade and replicate within host cells. In a previous study, a putative gene bab_RS27735 encoding an amino acid ABC transporter substrate-binding protein homologous to AapJ protein was found to be involved in Brucella abortus virulence. In this study, we successfully constructed a bab_RS27735 deletion mutant, Δ27735. Compared with the wild-type strain, the lipopolysaccharide pattern of the mutant was not changed, but the growth ability was slightly defected in the exponential phase...
March 29, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29583043/effect-of-oral-administration-of-robenacoxib-on-inhibition-of-paracentesis-induced-blood-aqueous-barrier-breakdown-in-healthy-cats
#3
Emily K Sharpe, Jessica M Meekins, James K Roush, Amy J Rankin, Butch KuKanich
OBJECTIVE To determine the effect of oral administration of robenacoxib on inhibition of anterior chamber paracentesis (ACP)-induced breakdown of the blood-aqueous barrier (BAB) and assess whether robenacoxib can cross an intact BAB in healthy cats. ANIMALS 12 healthy adult domestic shorthair cats. PROCEDURES Cats received robenacoxib (6-mg tablet in a treat, PO; n = 6) or a control treatment (treat without any drug, PO; 6) once daily for 3 days, beginning 1 day before ACP. One eye of each cat served as an untreated control, whereas the other underwent ACP, during which a 30-gauge needle was used to aspirate 100 μL of aqueous humor for determination of robenacoxib concentration...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29488103/multi-centre-phase-iv-trial-to-investigate-the-immunogenicity-of-a-new-liquid-formulation-of-recombinant-human-growth-hormone-in-adults-with-growth-hormone-deficiency
#4
G Johannsson, K Nespithal, U Plöckinger, V Alam, M McLean
PURPOSE: To investigate whether a new liquid formulation of recombinant human growth hormone (r-hGH) induces the production of binding antibodies (BAbs) in adults with congenital or adult-onset growth hormone deficiency (GHD). METHODS: Men or women aged 19-65 years with adult growth hormone deficiency who were r-hGH-naïve or had stopped treatment ≥ 1 month before screening were treated with between 0.15 and 0.30 mg/day r-hGH liquid formulation for 39 weeks...
February 27, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29438139/optimizing-pulmonary-embolism-computed-tomography-in-the-age-of-individualized-medicine-a-prospective-clinical-study
#5
Babs M F Hendriks, Nienke G Eijsvoogel, Madeleine Kok, Bibi Martens, Joachim E Wildberger, Marco Das
PURPOSE: The aim of the study was to simultaneously optimize contrast media (CM) injection and scan parameters for the individual patient during computed tomography pulmonary angiography (CTPA). METHODS: In this study (NCT02611115), 235 consecutive patients suspected of having pulmonary embolism were prospectively enrolled. Automated kV selection software on a third-generation multidetector computed tomography adapted tube voltage to the individual patient, based on scout scans...
February 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29426262/the-relationship-between-theory-of-mind-and-insight-in-obsessive-compulsive-disorder
#6
Rıza Gökçer Tulacı, Eylem Şahin Cankurtaran, Kadir Özdel, Nefise Öztürk, Erkan Kuru, İlker Özdemir
BACKGROUND: It is known that obsessive-compulsive disorder (OCD) patients with poor insight display more severe neuropsychological impairments than other patients with OCD. There are limited studies of OCD and theory of mind (ToM). AIM: To investigate ToM skills in patients with OCD and the relationship between insight and ToM skills by comparing OCD patients with good and poor insight. METHODS: Eighty patients with OCD and 80 healthy controls completed the structured clinical interview for DSM-IV axis I disorders, the Yale Brown Obsessive-Compulsive Scale, the Beck Anxiety and Beck Depression Inventories, and the Brown Assessment of Beliefs Scale...
February 9, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29362947/morphological-characterization-of-pulmonary-microvascular-disease-in-bronchopulmonary-dysplasia-caused-by-hyperoxia-in-newborn-mice
#7
Hidehiko Nakanishi, Shunichi Morikawa, Shuji Kitahara, Asuka Yoshii, Atsushi Uchiyama, Satoshi Kusuda, Taichi Ezaki
PURPOSE: Pulmonary microvascular injury is associated with the pathogenesis of bronchopulmonary dysplasia (BPD). To characterize the mechanisms of pulmonary vascular disease resulting from BPD, we studied the ultrastructural changes affecting pulmonary microvasculature. METHODS: Newborn ICR mice were exposed to 85% hyperoxia or normoxia for 14 days, and then normal air replacement conditions for the following 7 days. At postnatal day (P)14 and P21, lungs were harvested for ultrastructural examination and assessment of pulmonary hypertension...
January 23, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29299525/communication-related-affective-behavioral-and-cognitive-reactions-in-speakers-with-spasmodic-dysphonia
#8
Christopher R Watts, Martine Vanryckeghem
Objectives: To investigate the self-perceived affective, behavioral, and cognitive reactions associated with communication of speakers with spasmodic dysphonia as a function of employment status. Study Design: Prospective cross-sectional investigation. Methods: 148 Participants with spasmodic dysphonia (SD) completed an adapted version of the Behavior Assessment Battery (BAB-Voice), a multidimensional assessment of self-perceived reactions to communication...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29297463/cis-regulatory-evolution-integrated-the-bric-%C3%A3-brac-transcription-factors-into-a-novel-fruit-fly-gene-regulatory-network
#9
Maxwell J Roeske, Eric M Camino, Sumant Grover, Mark Rebeiz, Thomas Michael Williams
Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis -regulatory element (CRE) mutations, and interpreting the protein-DNA interactions they alter. We investigated evolutionary changes in the duplicated Bric-à-brac (Bab) transcription factors and a key Bab target gene in a GRN underlying the novel dimorphic pigmentation of D. melanogaster and its relatives...
January 3, 2018: ELife
https://www.readbyqxmd.com/read/29295862/perturbed-bone-composition-and-integrity-with-disorganized-osteoblast-function-in-zinc-receptor-gpr39-deficient-mice
#10
Milena Jovanovic, Felix N Schmidt, Gali Guterman-Ram, Hanifeh Khayyeri, Sahar Hiram-Bab, Ayelet Orenbuch, Svetlana Katchkovsky, Anastasia Aflalo, Hanna Isaksson, Björn Busse, Katharina Jähn, Noam Levaot
Changes in bone matrix composition are frequently found with bone diseases and may be associated with increased fracture risk. Bone is rich in the trace element zinc. Zinc was established to play a significant role in the growth, development, and maintenance of healthy bones; however, the mechanisms underlying zinc effects on the integrity of the skeleton are poorly understood. Here, we show that the zinc receptor (ZnR)/Gpr39 is required for normal bone matrix deposition by osteoblasts. Initial analysis showed that Gpr39-deficient ( Gpr39-/- ) mice had weaker bones as a result of altered bone composition...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29278699/postnatal-development-of-bitter-taste-avoidance-behavior-in-mice-is-associated-with-actin-dependent-localization-of-bitter-taste-receptors-to-the-microvilli-of-taste-cells
#11
Atsuko Yamashita, Kaori Kondo, Yoshimi Kunishima, Sachiko Iseki, Takashi Kondo, Masato S Ota
Bitter taste avoidance behavior (BAB) plays a fundamental role in the avoidance of toxic substances with a bitter taste. However, the molecular basis underlying the development of BAB is unknown. To study critical developmental events by which taste buds turn into functional organs with BAB, we investigated the early phase development of BAB in postnatal mice in response to bitter-tasting compounds, such as quinine and thiamine. Postnatal mice started to exhibit BAB for thiamine and quinine at postnatal day 5 (PD5) and PD7, respectively...
January 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29274505/age-related-regulation-of-bone-formation-by-the-sympathetic-cannabinoid-cb1-receptor
#12
Saif Deis, Raj Kamal Srivastava, Inigo Ruiz de Azua, Laura Bindila, Saja Baraghithy, Beat Lutz, Itai Bab, Joseph Tam
The endocannabinoid (eCB) system, including its receptors, ligands, and their metabolizing enzymes, plays an important role in bone physiology. Skeletal cannabinoid type 1 (CB1) receptor signaling transmits retrograde signals that restrain norepinephrine (NE) release, thus transiently stimulating bone formation following an acute challenge, suggesting a feedback circuit between sympathetic nerve terminals and osteoblasts. To assess the effect of chronic in vivo occurrence of this circuit, we characterized the skeletal phenotype of mice with a conditional deletion of the CB1 receptor in adrenergic/noradrenergic cells, including sympathetic nerves...
March 2018: Bone
https://www.readbyqxmd.com/read/29259034/ablation-of-the-mammalian-lectin-galectin-8-induces-bone-defects-in-mice
#13
Yaron Vinik, Hadas Shatz-Azoulay, Sahar Hiram-Bab, Leonid Kandel, Yankel Gabet, Gurion Rivkin, Yehiel Zick
Mice overexpressing galectin-8 [gal-8 transgenic (Tg)], a secreted mammalian lectin, exhibit enhanced bone turnover and reduced bone mass, similar to cases of postmenopausal osteoporosis. Here, we show that gal-8 knockout (KO) mice have increased bone mass accrual at a young age but exhibit accelerated bone loss during adulthood. These phenotypes can be attributed to a gal-8-mediated increase in receptor activator of NF-κB ligand (RANKL) expression that promotes osteoclastogenesis, combined with direct inhibition of osteoblasts differentiation, evident by reduced bone morphogenetic protein (BMP) signaling, reduced phosphorylation of receptor regulated mothers against decapentaplegic homolog (R-SMAD) and reduced expression of osteoblasts differentiation markers osterix, osteocalcin, runt-related transcription factor 2 (RUNX2), dentin matrix acidic phosphoprotein-1 (DMP1), and alkaline phosphatase...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29216465/optical-source-profiles-of-brown-carbon-in-size-resolved-particulate-matter-from-typical-domestic-biofuel-burning-over-guanzhong-plain-china
#14
Yali Lei, Zhenxing Shen, Tian Zhang, Qian Zhang, Qiyuan Wang, Jian Sun, Xuesong Gong, Junji Cao, Hongmei Xu, Suixin Liu, Liu Yang
In this study, both PM2.5 and size-resolved source samples were collected from a "heated kang" and an advanced stove to investigate the optical properties of brown carbon (BrC). The light-absorption coefficient (babs ), the absorption Ångström exponent (AAE), and the mass absorption cross-section (MAC) of both water and methanol-extracted BrC were investigated. The methanol-extracted BrC (BrCmethanol ) had higher light absorption than water-extracted BrC (BrCwater ). The value of PM2.5 babs of BrCmethanol at 365nm (babs365,methanol ) dramatically decreased from 64,669...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29202427/religiosity-and-religious-delusions-in-schizophrenia-an-observational-study-in-a-hindu-population
#15
Anand Mishra, Basudeb Das, Nishant Goyal
BACKGROUND: Religion exerts a significant effect on the lives of many individuals including people with mental illness. As evidences keep accumulating, role of religion in mental illness is gaining importance. OBJECTIVES: The study was designed to study the effects of religiosity on religious delusions, its presentation, acute course and outcome in schizophrenia. METHOD: The study was a naturalistic observational study. Subjects with schizophrenia were grouped into those with religious (RG) and with non-religious delusions (NG)...
February 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29107979/helicobacter-pylori-bab-characterization-in-clinical-isolates-from-bhutan-myanmar-nepal-and-bangladesh
#16
Shamshul Ansari, Evariste Tshibangu Kabamba, Pradeep Krishna Shrestha, Hafeza Aftab, Thein Myint, Lotay Tshering, Rabi Prakash Sharma, Nwe Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Thawee Ratanachu-Ek, Ratha-Korn Vilaichone, Varocha Mahachai, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka
BACKGROUND: Helicobacter pylori BabA is an important outer membrane protein that involves in the attachment to the gastric mucosa and enhances the virulence property of the bacterium. This study was aimed to characterize the bab genotypes, to evaluate its association with cagA, vacA and clinical diseases as well as degree of gastric inflammation. METHODS: H. pylori isolates from four countries were subjected for the characterization of bab. The locus specific forward and bab specific reverse primers were used to get the specific products by PCR, which could distinguish the three locus (A, B and C)...
2017: PloS One
https://www.readbyqxmd.com/read/29082458/high-level-of-b19-strain-detection-in-brazilian-cattle-semen
#17
M P S Lourencetti, M A Souza, M R Ganda, J P Santos, A Ferreira Júnior, S Miyashiro, A M C Lima
Semen contaminated with microorganisms can disseminate serious diseases including brucellosis. The objectives of this study were to detect Brucella-specific antibodies and Brucella abortus DNA in samples of blood and fresh semen from 100 animals older than 20 months. The samples were collected on farms and in semen collection and processing centers (CCPS). The serum samples were evaluated by Rose Bengal test (RBT). B. abortus DNA was detected by a polymerase chain reaction (PCR) using BAB and IS771 primers...
February 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29034349/future-applications-of-fusion-fluorescence-imaging-during-laparoscopic-procedures
#18
EDITORIAL
Babs G Sibinga Mulder, Alexander L Vahrmeijer, J Sven D Mieog
No abstract text is available yet for this article.
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29016860/primary-angle-closure-glaucoma-pacg-susceptibility-gene-plekha7-encodes-a-novel-rac1-cdc42-gap-that-modulates-cell-migration-and-blood-aqueous-barrier-function
#19
Mei-Chin Lee, William Shei, Anita S Chan, Boon-Tin Chua, Shuang-Ru Goh, Yaan-Fun Chong, Maryam H Hilmy, Monisha E Nongpiur, Mani Baskaran, Chiea-Chuen Khor, Tin Aung, Walter Hunziker, Eranga N Vithana
PLEKHA7, a gene recently associated with primary angle closure glaucoma (PACG), encodes an apical junctional protein expressed in components of the blood aqueous barrier (BAB). We found that PLEKHA7 is down-regulated in lens epithelial cells and in iris tissue of PACG patients. PLEKHA7 expression also correlated with the C risk allele of the sentinel SNP rs11024102 with the risk allele carrier groups having significantly reduced PLEKHA7 levels compared to non-risk allele carriers. Silencing of PLEKHA7 in human immortalized non-pigmented ciliary epithelium (h-iNPCE) and primary trabecular meshwork cells, which are intimately linked to BAB and aqueous humor outflow respectively, affected actin cytoskeleton organization...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28960351/a-practical-approach-to-assess-inhalation-toxicity-of-metal-oxide-nanoparticles-in-vitro
#20
Anita C A Dankers, C Frieke Kuper, Anja J Boumeester, Babs O Fabriek, Ingeborg M Kooter, Mariska Gröllers-Mulderij, Peter Tromp, Inge Nelissen, Esther K Zondervan-Van Den Beuken, Rob J Vandebriel
Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2 , Mn2 O3 , CuO, ZnO, Co3 O4 and WO3 ; 27-108 μg ml-1 ) using human primary 3-dimensional airway epithelium (MucilAir™) and dendritic cell (DC) models. Metal oxide NPs were mainly aggregated/agglomerated in the cell media, as determined by dynamic light scattering, scanning electron microscopy and differential centrifugal sedimentation...
February 2018: Journal of Applied Toxicology: JAT
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