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https://www.readbyqxmd.com/read/28718808/beta-palmitate-improves-bone-length-and-quality-during-catch-up-growth-in-young-rats
#1
Meytal Bar-Maisels, Yankel Gabet, Raanan Shamir, Sahar Hiram-Bab, Metsada Pasmanik-Chor, Moshe Phillip, Fabiana Bar-Yoseph, Galia Gat-Yablonski
Palmitic acid (PA) is the most abundant saturated fatty acid in human milk, where it is heavily concentrated in the sn-2-position (termed beta palmitate, BPA) and as such is conserved in all women, regardless of their diet or ethnicity, indicating its physiological and metabolic importance. We hypothesized that BPA improves the efficiency of nutrition-induced catch up growth as compared to sn-1,3 PA, which is present in vegetable oil. Pre-pubertal male rats were subjected to a 17 days food restriction followed by re-feeding for nine days with 1,3 PA or BPA-containing diets...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28702355/whole-genome-sequencing-and-annotation-of-halophilic-salinicoccus-sp-bab-3246-isolated-from-the-coastal-region-of-gujarat
#2
Vishal Mevada, Shradhdha Patel, Jignesh Pandya, Himani Joshi, Rajesh Patel
Salinicoccus sp. BAB 3246 is a halophilic bacterium isolated from a marine water sample collected from the coastal region of Gujarat, India, from a surface water stream. Based on 16sRNA sequencing, the organism was identified as Salinicoccus sp. BAB 3246 (Genebank ID: KF889285). The present work was performed to determine the whole genome sequence of the organism using Ion Torrent PGM platform followed by assembly using the CLC genomics workbench and genome annotation using RAST, BASys and MaGe. The complete genome sequence was 713,204 bp identified by with second largest size for Salinicoccus sp...
September 2017: Genomics Data
https://www.readbyqxmd.com/read/28694200/the-prevention-and-treatment-of-smoking-and-tobacco-use-during-pregnancy-in-selected-indigenous-communities-in-high-income-countries-of-usa-canada-australia-and-new-zealand-an-evidence-based-review
#3
REVIEW
Gillian S Gould, Ling Li Lim, Joerg Mattes
IMPORTANCE: Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and bab(ies). Tobacco use during pregnancy has reduced in high-income countries; but not for Indigenous women in Australia, New Zealand, the United States, and Canada. APPROACH/AIM: This evidence-based review focusses on tobacco use among Indigenous pregnant women in high-income countries, who share a history of European colonisation...
July 7, 2017: Chest
https://www.readbyqxmd.com/read/28683806/evaluating-the-effect-of-the-helping-mothers-survive-bleeding-after-birth-hms-bab-training-in-tanzania-and-uganda-study-protocol-for-a-randomised-controlled-trial
#4
Claudia Hanson, Andrea B Pembe, Fadhlun Alwy, Susan Atuhairwe, Sebalda Leshabari, Jessica Morris, Frank Kaharuza, Gaetano Marrone
BACKGROUND: Postpartum haemorrhage complicates approximately 10% of all deliveries and contributes to at least a quarter of all maternal deaths worldwide. The competency-based Helping Mothers Survive Bleeding after Birth (HMS BAB) training was developed to support evidence-based management of postpartum haemorrhage. This one-day training includes low-cost MamaNatalie® birthing simulators and addresses both prevention and first-line treatment of haemorrhage. While evidence is accumulating that the training improves health provider's knowledge, skills and confidence, evidence is missing as to whether this translates into improved practices and reduced maternal morbidity and mortality...
July 6, 2017: Trials
https://www.readbyqxmd.com/read/28658656/solubility-products-of-sparingly-soluble-barium-perborates-in-aqueous-solution-that-contains-b-oh-3-and-h2o2-at-25%C3%A2-c
#5
Jui-Yen Lin, Yi-Jin Song, Yu-Jen Shih, Yao-Hui Huang
Chemical oxo-precipitation (COP) has become a promising method for treating boron wastewater at room temperature; it uses hydrogen peroxide to convert boric acid to perborate species, which are precipitated using alkaline earth metals. In this work, solubility models of barium perborates were established to predict residual boron levels from COP. The solubility product constants (pKsp) of two major barium perborates - amorphous Ba(B(OH)3OOH)2 (A-BaPB) and crystalline BaB(OH)2(OO)2B(OH)2 (C-BaPB) - were experimentally estimated (8...
June 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28651226/insight-in-body-dysmorphic-disorder-bdd-relative-to-obsessive-compulsive-disorder-ocd-and-psychotic-disorders-revisiting-this-issue-in-light-of-dsm-5
#6
Wei Lin Toh, David J Castle, Rachel L Mountjoy, Ben Buchanan, John Farhall, Susan L Rossell
INTRODUCTION: In DSM-5, body dysmorphic disorder (BDD) was reclassified under the obsessive-compulsive and related disorders (OCRDs), but little is known about the nature of BDD beliefs. This study aimed to compare level of insight in BDD and consider related implications for DSM-5 classification. METHOD: Participants were 27 BDD, 19 obsessive-compulsive disorder (OCD), and 20 psychosis (SZ) participants as well as 42 non-clinical controls (NC), who completed the Brown Assessment of Beliefs Scale (BABS) and Peters Delusions Inventory (PDI)...
August 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28635332/50-ethanol-extract-of-orthosiphon-stamineus-modulates-genotoxicity-and-clastogenicity-induced-by-mitomycin-c
#7
Dhamraa Waleed Al-Dualimi, Aman Shah Abdul Majid, Sarah Furqan Faisal Al-Shimary, Amal Aziz Al-Saadi, Raghdaa Al Zarzour, Muhammad Asif, Chern Ein Oon, Amin Malik Shah Abdul Majid
Herbal products contain a variety of compounds which may be useful in protecting against cellular damage caused by mutagens. Orthosiphon stamineus (O.s) also known as Cat whiskers. The herb has been shown anti-oxidative properties and can modulate key cellular proteins that have cytoprotective effect. The study aimed to evaluate the effects of different doses (250, 500 and 1000 mg kg(-1)) of 50% ethanol extract of O.s (Et. O.s) on micro-nucleated polychromatic erythrocytes (MNPCE), Polychromatic to normachromatic erythrocytes ratio (PCE/NCE), Mitotic index (MI), and Chromosomal aberration (CA) in Bab/c mice...
June 21, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28631482/carbohydrate-bis-acetal-based-substrates-as-tunable-fluorescence-quenched-probes-for-monitoring-exo-glycosidase-activity
#8
Samy Cecioni, David J Vocadlo
Tunable Förster resonance energy transfer (FRET)-quenched substrates are useful for monitoring the activity of various enzymes within their relevant physiological environments. Development of FRET-quenched substrates for exo-glycosidases, however, has been hindered by their constrained pocket-shaped active sites. Here we report the design of a new class of substrate that overcomes this problem. These Bis-Acetal-Based Substrates (BABS) bear a hemiacetal aglycon leaving group that tethers fluorochromes in close proximity, also positioning them distant from the active site pocket...
June 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28629516/context-dependent-skeletal-effects-of-erythropoietin
#9
Sahar Hiram-Bab, Drorit Neumann, Yankel Gabet
Erythropoietin (Epo) is the main hormone that regulates the production of red blood cells (hematopoiesis), by stimulating their progenitors. Beyond this vital function, several emerging roles have been noted for Epo in other tissues, including neurons, heart, and retina. The skeletal system is also affected by Epo; however, its actions on bone are, as yet, controversial. Here, we review the seemingly contradicting evidence regarding Epo effects on bone remodeling. We also discuss the evidence pointing to a direct vs indirect effect of Epo on the osteoblastic and osteoclastic cell lineages...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28608768/effects-of-dog-assisted-therapy-on-communication-and-basic-social-skills-of-adults-with-intellectual-disabilities-a-pilot-study
#10
Ivano Scorzato, Leonardo Zaninotto, Michela Romano, Chiara Menardi, Lino Cavedon, Alessandra Pegoraro, Laura Socche, Piera Zanetti, Deborah Coppiello
Thirty-nine adults with severe to profound intellectual disability (ID) were randomly assigned to either an experimental group (n = 21) or a control group (n = 18). Assessment was blinded and included selected items from the International Classification of Functioning, Disability and Health (ICF), the Behavioral Assessment Battery (BAB), and the Learning Accomplishment Profile (LAP). The experimental group, who attended a dog-assisted treatment intervention over a 20-week period, showed significant improvements in several cognitive domains, including attention to movement (BAB-AM), visuomotor coordination (BAB-VM), exploratory play (BAB-EP), and motor imitation (BAB-CO-MI), as well as in some social skills, as measured by LAP items...
June 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28550121/bcl6-represses-antiviral-resistance-in-follicular-t-helper-cells
#11
Tohti Amet, Young Min Son, Li Jiang, In Su Cheon, Su Huang, Samir K Gupta, Alexander L Dent, Luis J Montaner, Qigui Yu, Jie Sun
Follicular Th (Tfh) cells are a distinct subset of Th cells that help B cells produce class-switched antibodies. Studies have demonstrated that Tfh cells are highly prone to HIV infection and replication. However, the molecular mechanisms underlying this phenomenon are largely unclear. Here, we show that murine and human Tfh cells have diminished constitutive expression of IFN-stimulated genes (ISGs) inclusive of antiviral resistance factor MX dynamin-like GTPase 2 (MX2) and IFN-induced transmembrane 3 (IFITM3) compared with non-Tfh cells...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28520413/temporal-characteristics-of-brown-carbon-over-the-central-indo-gangetic-plain
#12
Rangu Satish, Puthukkadan Shamjad, Navaneeth Thamban, Sachchida Tripathi, Neeraj Rastogi
Recent global models estimate that light absorption by brown carbon (BrC) in several regions of the world is ∼30-70% of that due to black carbon (BC). It is, therefore, important to understand its sources and characteristics on temporal and spatial scales. In this study, we conducted semicontinuous measurements of water-soluble organic carbon (WSOC) and BrC using particle-into-liquid sampler coupled with a liquid waveguide capillary cell and total organic carbon analyzer (PILS-LWCC-TOC) over Kanpur (26.5°N, 80...
May 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28481360/a-chronic-low-dose-of-%C3%AE-9-tetrahydrocannabinol-thc-restores-cognitive-function-in-old-mice
#13
Andras Bilkei-Gorzo, Onder Albayram, Astrid Draffehn, Kerstin Michel, Anastasia Piyanova, Hannah Oppenheimer, Mona Dvir-Ginzberg, Ildiko Rácz, Thomas Ulas, Sophie Imbeault, Itai Bab, Joachim L Schultze, Andreas Zimmer
The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the brain tissues of older animals and the levels of the major endocannabinoid 2-arachidonoylglycerol (2-AG) are lower...
June 2017: Nature Medicine
https://www.readbyqxmd.com/read/28454328/reconstruction-of-mandibular-defects-with-autogenous-bone-and-decellularized-bovine-bone-grafts-with-freeze-dried-bone-marrow-stem-cell-paracrine-factors
#14
Ann Kakabadze, Konstantine Mardaleishvili, George Loladze, Lia Karalashvili, Gocha Chutkerashvili, David Chakhunashvili, Zurab Kakabadze
The gold standard following segmental mandibulectomy is vascularized autologous bone graft in the form of the fibula flap. However, in bone reconstruction the use of autogenous bone does not always guarantee a successful outcome. The aim of the present investigation was to develop a novel biologically active bone (BAB) graft, and to use it for the reconstruction of large size defects of the mandible bone following tumor resection. In the first part of the present study, biologically active bone graft was developed by using human freeze-dried bone marrow stem cells (BMSCs) paracrine factors and three-dimensional bone scaffold derived from cancellous bovine bone following decellularization...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28435769/gambling-behavior-among-macau-college-and-university-students
#15
Sut Mei Kam, Irene Lai Kuen Wong, Ernest Moon Tong So, David Kin Cheong Un, Chris Hon Wa Chan
This survey investigated gambling behavior among Chinese students studying in Macau colleges and universities. It also aimed to examine the relationship between problem gambling, affect states and sensation seeking propensity. A convenience sample of 999 students (370 men, 629 women) filled a self-administered questionnaire consisted of the Problem Gambling Severity Index (PGSI) (Ferris and Wynne in The Canadian problem gambling index: User manual. Canadian Centre on Substance Abuse, Toronto 2001a), the 8-item Brief Sensation Seeking Scale (BSSS-8) (Hoyle et al...
2017: Asian journal of gambling issues and public health
https://www.readbyqxmd.com/read/28426827/correction-helicobacter-pylori-bab-paralog-distribution-and-association-with-caga-vaca-and-homa-b-genotypes-in-american-and-south-korean-clinical-isolates
#16
Aeryun Kim, Stephanie L Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Ho Jin Cha, Wan Jin Lee, June Kim, Judith Romero-Gallo, Richard M Peek, D Scott Merrell, Jeong-Heon Cha
[This corrects the article DOI: 10.1371/journal.pone.0137078.].
2017: PloS One
https://www.readbyqxmd.com/read/28416744/real-time-near-infrared-fluorescence-imaging-using-crgd-zw800-1-for-intraoperative-visualization-of-multiple-cancer-types
#17
Henricus J M Handgraaf, Martin C Boonstra, Hendrica A J M Prevoo, Joeri Kuil, Mark W Bordo, Leonora S F Boogerd, Babs G Sibinga Mulder, Cornelis F M Sier, Maaike L Vinkenburg-van Slooten, A Rob P M Valentijn, Jacobus Burggraaf, Cornelis J H van de Velde, John V Frangioni, Alexander L Vahrmeijer
Incomplete resections and damage to critical structures increase morbidity and mortality of patients with cancer. Targeted intraoperative fluorescence imaging aids surgeons by providing real-time visualization of tumors and vital structures. This study evaluated the tumor-targeted zwitterionic near-infrared fluorescent peptide cRGD-ZW800-1 as tracer for intraoperative imaging of multiple cancer types. cRGD-ZW800-1 was validated in vitro on glioblastoma (U-87 MG) and colorectal (HT-29) cell lines. Subsequently, the tracer was tested in orthotopic mouse models with HT-29, breast (MCF-7), pancreatic (BxPC-3), and oral (OSC-19) tumors...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407743/new-drugs-new-toxicities-severe-side-effects-of-modern-targeted-and-immunotherapy-of-cancer-and-their-management
#18
REVIEW
Frank Kroschinsky, Friedrich Stölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl, Peter Schellongowski
Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as mild or moderate, but severe and life-threatening complications requiring ICU admission also occur. This review will focus on pathophysiology, symptoms, and management of these events based on the available literature.While standard antineoplastic therapy is associated with immunosuppression and infections, some of the recent approaches induce overwhelming inflammation and autoimmunity...
April 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28406732/black-adzuki-bean-vigna-angularis-attenuates-high-fat-diet-induced-colon-inflammation-in-mice
#19
Jin-Seon Yook, Kyung-Ah Kim, Mina Kim, Youn-Soo Cha
Adzuki beans (Vigna angularis), one of the most important legume crops in East Asia, have been shown to possess potential antioxidant and anti-inflammatory effects in mice. Here, we investigated the effects of black adzuki bean (BAB) on colon inflammation triggered by high-fat diet (HD)-induced obesity in mice. We also isolated lipopolysaccharide (LPS)-stimulated peritoneal macrophages and assessed inflammation-related parameters. We found that BAB decreased the concentrations of LPS and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mice with HD-induced obesity...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28376905/characterization-of-brucella-abortus-mutant-strain-%C3%AE-22915-a-potential-vaccine-candidate
#20
Yanqing Bao, Mingxing Tian, Peng Li, Jiameng Liu, Chan Ding, Shengqing Yu
Brucellosis, caused by Brucella spp., is an important zoonosis worldwide. Vaccination is an effective strategy for protection against Brucella infection in livestock in developing countries and in wildlife in developed countries. However, current vaccine strains including S19 and RB51 are pathogenic to humans and pregnant animals, limiting their use. In this study, we constructed the Brucella abortus (B. abortus) S2308 mutant strain Δ22915, in which the putative lytic transglycosylase gene BAB_RS22915 was deleted...
April 4, 2017: Veterinary Research
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