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https://www.readbyqxmd.com/read/28180936/fn14-hepatic-progenitor-cells-are-associated-with-liver-fibrosis-in-biliary-atresia
#1
Lulu Zheng, Zhibao Lv, Zhenhua Gong, Qingfeng Sheng, Zhimei Gao, Yuting Zhang, Shenghua Yu, Junmei Zhou, Zhengjun Xi, Xueli Wang
PURPOSE: The liver in biliary atresia (BA) is characterized by progressing fibrosis which is promoted by unclear reasons. We aimed to understand the factors influencing liver fibrosis. This study hypothesized that HPCs (hepatic progenitor cells) are activated and associated with liver fibrosis in biliary atresia. METHODS: Liver samples from biliary atresia patients are as BA group, and the normal liver derived from hepatoblastoma infants during operation are control group...
February 8, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28157424/a-rho-associated-kinase-inhibitor-protects-permeability-in-a-cell-culture-model-of-ocular-disease-and-reduces-aqueous-flare-in-anterior-uveitis
#2
Hiroshi Yamada, Masahiko Yoneda, Shingo Inaguma, Masahiko Gosho, Yusuke Murasawa, Zenzo Isogai, Masahiro Zako
PURPOSE: Recent clinical and experimental studies have reported favorable results when using Rho-associated kinase (ROCK) inhibitors for ocular disease, and in cell culture. Disruption of the human, nonpigmented ciliary epithelial cells (HNPCECs) that comprise the blood-aqueous barrier (BAB) induces anterior uveitis; these cells therefore provide a useful cell model of ocular disease. In this study, we examined the effects of ROCK inhibitors in anterior uveitis and in HNPCECs. METHODS: Aqueous flare values and intraocular pressures (IOPs) were determined in patients with anterior uveitis, 2 weeks after administration of ripasudil hydrochloride hydrate, a commercial ROCK inhibitor used to treat glaucoma or ocular hypertension...
February 3, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28130237/identification-of-protein-complexes-by-integrating-multiple-alignment-of-protein-interaction-networks
#3
Cheng-Yu Ma, Yi-Ping Phoebe Chen, Bonnie Berger, Chung-Shou Liao
MOTIVATION: Protein complexes are one of the keys to studying the behavior of a cell system. Many biological functions are carried out by protein complexes. During the past decade, the main strategy used to identify protein complexes from high-throughput network data has been to extract near-cliques or highly dense subgraphs from a single protein-protein interaction (PPI) network. Although experimental PPI data has increased significantly over recent years, most PPI networks still have many false positive interactions and false negative edge loss due to the limitations of high-throughput experiments...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28079964/bab-random-c-monomer-sequence-via-radical-terpolymerization-of-limonene%C3%A2-a-maleimide%C3%A2-b-and-methacrylate%C3%A2-c-terpene-polymers-with-randomly-distributed-periodic-sequences
#4
Masataka Ojika, Kotaro Satoh, Masami Kamigaito
A naturally abundant terpene, limonene (A), was radically polymerized with a maleimide derivative (B) and methacrylate (C) in a fluorinated alcohol to give terpolymers with unprecedented BAB-random-C sequences in which the BAB monomer sequence was randomly copolymerized with a C unit. In each binary system, limonene was hardly copolymerized with methacrylate while it was efficiently copolymerized with maleimide to result in a 1:2-alternating BAB periodic sequence, in part due to the penultimate effects and hydrogen-bonding interactions with fluoroalcohol...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28006006/the-gulf-of-aden-intermediate-water-intrusion-regulates-the-southern-red-sea-summer-phytoplankton-blooms
#5
Denis Dreano, Dionysios E Raitsos, John Gittings, George Krokos, Ibrahim Hoteit
Knowledge on large-scale biological processes in the southern Red Sea is relatively limited, primarily due to the scarce in situ, and satellite-derived chlorophyll-a (Chl-a) datasets. During summer, adverse atmospheric conditions in the southern Red Sea (haze and clouds) have long severely limited the retrieval of satellite ocean colour observations. Recently, a new merged ocean colour product developed by the European Space Agency (ESA)-the Ocean Color Climate Change Initiative (OC-CCI)-has substantially improved the southern Red Sea coverage of Chl-a, allowing the discovery of unexpected intense summer blooms...
2016: PloS One
https://www.readbyqxmd.com/read/28000527/epigenetic-regulation-of-immune-checkpoints-another-target-for-cancer-immunotherapy
#6
Mahmoud A Ali, Marwa Matboli, Marwa Tarek, Maged Reda, Kamal M Kamal, Mahmoud Nouh, Ahmed M Ashry, Ahmed Fath El-Bab, Hend A Mesalam, Ayman El-Sayed Shafei, Omar Abdel-Rahman
Epigenetic changes in oncogenes and tumor-suppressor genes contribute to carcinogenesis. Understanding the epigenetic and genetic components of tumor immune evasion is crucial. Few cancer genetic mutations have been linked to direct correlations with immune evasion. Studies on the epigenetic modulation of the immune checkpoints have revealed a critical interaction between epigenetic and immune modulation. Epigenetic modifiers can activate many silenced genes. Some of them are immune checkpoints regulators that turn on immune responses and others turn them off resulting in immune evasion...
January 2017: Immunotherapy
https://www.readbyqxmd.com/read/27988311/first-detection-and-molecular-identification-of-babesia-microti-in-rattus-losea-captured-from-the-offshore-kinmen-island-of-taiwan
#7
Li-Lian Chao, Wen-Ching Yu, Chien-Ming Shih
Babesia microti was firstly detected and identified in brown country rats (Rattus losea, Swinhoe) captured from the offshore Kinmen Island of Taiwan. The prevalence of Babesia infection in 283 rodents was screened by polymerase chain reaction (PCR) assay using a piroplasma-conserved primer set (Piro A/B) and the thirty-seven PCR-positive rodents were further examined by PCR using a species-specific primer set (Bab 1/4) targeting the gene encoding the nuclear small-subunit ribosomal RNA (18S rRNA) of Babesia species...
December 12, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27959622/dwi-for-assessment-of-rectal-cancer-nodes-after-chemoradiotherapy-is-the-absence-of-nodes-at-dwi-proof-of-a-negative-nodal-status
#8
Miriam M van Heeswijk, Doenja M J Lambregts, Walter M Palm, Babs M F Hendriks, Monique Maas, Geerard L Beets, Regina G H Beets-Tan
OBJECTIVE: When considering organ preservation in patients with rectal cancer with good tumor response, assessment of a node-negative status after chemoradiation therapy (CRT) is important. DWI is a very sensitive technique to detect nodes. The study aim was to test the hypothesis that the absence of nodes at DWI after CRT is concordant with a ypN0 status. MATERIALS AND METHODS: A retrospective study was performed of 90 patients with rectal cancer treated with CRT followed by restaging MRI at 1...
December 13, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27942244/characterization-of-tamyb10-allelic-variants-and-development-of-sts-marker-for-pre-harvest-sprouting-resistance-in-chinese-bread-wheat
#9
Y Wang, X L Wang, J Y Meng, Y J Zhang, Z H He, Y Yang
Wheat grain color does not only affect the brightness of flour but also seed dormancy and pre-harvest sprouting (PHS) tolerance. The transcription factor Tamyb10 is an important candidate for R-1 gene, and the expression of its homologs determines wheat seed coat color. In the present study, the allelic variations of Tamyb10 were explored in a set of Chinese bread wheat varieties and advanced lines with different PHS tolerance, and a sequenced-tagged site (STS) marker for Tamyb10-D1 gene was developed, designated as Tamyb10D, which could be used as an efficient and reliable marker to evaluate the depth dormancy of wheat seeds...
2016: Molecular Breeding: New Strategies in Plant Improvement
https://www.readbyqxmd.com/read/27899126/new-epidemiological-aspects-of-visceral-and-cutaneous-leishmaniasis-in-taza-morocco
#10
Maryam Hakkour, Asmae Hmamouch, Mohamed Mahmoud El Alem, Abdelkbir Rhalem, Fatima Amarir, Mohamed Touzani, Abderrahim Sadak, Hajiba Fellah, Faiza Sebti
BACKGROUND: Leishmaniasis is considered among the main endemic diseases in Morocco. However, further knowledge about epidemiological aspects of this disease is needed in several provinces to plan control and preventive strategies to tackle the disease. The present study aims to determine the epidemiological aspect of cutaneous and visceral leishmaniasis in Taza Province from 2007-2014 and to identify the circulating species in this province. RESULTS: The temporal study from 2007 to 2014 showed that the number of cutaneous leishmaniasis cases increased since 2010...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27888458/helicobacter-pylori-outer-membrane-protein-homc-shows-geographic-dependent-polymorphism-that-is-influenced-by-the-bab-family
#11
Aeryun Kim, Stephanie L Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Yun Hui Choi, Hanfu Su, Yeong-Eui Jeon, Youngmin A Hong, Yun-Jung Yoo, D Scott Merrell, Jeong-Heon Cha
The array of outer membrane proteins (OMPs) found in Helicobacter pylori provides a crucial component for persistent colonization within the gastric niche. Not only does H. pylori harbor a wide number of OMPs, but these OMPs often vary across strains; this likely contributes to immune evasion, adaptation during long term colonization, and potentially differential disease progression. Previous work from our group described OMP differences among the Bab family (babA, babB, and babC) and Hom family (homA and homB) from 80 American H...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27888376/laser-flare-cell-photometer-principle-and-significance-in-clinical-and-basic-ophthalmology
#12
REVIEW
Mitsuru Sawa
A slit-lamp examination is an indispensable and essential clinical evaluation method in ophthalmology, but, it is qualitative subjective. To complement its weaknesses in making a quantitative evaluation of flare intensity and number of cells in the aqueous humor in the eye, we invented the laser flare-cell photometer in 1988. The instrument enables a non-invasive quantitative evaluation of flare intensity and number of cells in the aqueous with good accuracy and repeatability as well as maneuverability equal to slit-lamp microscopy...
November 25, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27885593/campylobacter-jejuni-isolation-enumeration-from-environmental-samples
#13
Kelli L Hiett
Currently, there is no universally accepted standard media or method for the recovery of Campylobacter species. This is likely due to the ubiquity of the organism in nature, the complex sample matrices from which the organism is often recovered, as well as the fragile/viable-but nonculturable state the organism assumes in response to stress. The use of a sterile filter placed upon a nonselective Brucella Agar Blood Plate (BAB), followed by incubation at 37 °C in a hydrogen-containing atmosphere (Campycheck), is one method to recover stressed and emerging Campylobacter spp...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27828855/the-cross-reactivity-of-binding-antibodies-with-different-interferon-beta-formulations-used-as-disease-modifying-drugs-in-multiple-sclerosis-patients
#14
Agnieszka Wencel-Warot, Slawomir Michalak, Marcin Warot, Alicja Kalinowska-Lyszczarz, Radoslaw Kazmierski
Interferon beta (IFNb) preparations are commonly used as first-line therapy in relapsing-remitting multiple sclerosis (RRMS). They are, however, characterized by limited efficacy, partly due to the formation of anti-IFNb antibodies in patients.In this pilot study, we assessed with the ELISA method the presence of the binding antibodies (BAbs) against interferon beta after 2 years of therapy with subcutaneous interferon beta 1a (Rebif) in 49 RRMS patients. Antibody levels were established again within 1 year after treatment withdrawal...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27672215/targeted-next-generation-sequencing-of-fna-derived-dna-in-pancreatic-cancer
#15
Babs G Sibinga Mulder, J Sven D Mieog, Henricus J M Handgraaf, Arantza Farina Sarasqueta, Hans F A Vasen, Thomas P Potjer, Rutger-Jan Swijnenburg, Saskia A C Luelmo, Shirin Feshtali, Akin Inderson, Alexander L Vahrmeijer, Bert A Bonsing, Tom van Wezel, Hans Morreau
To improve the diagnostic value of fine-needle aspiration (FNA)-derived material, we perform targeted next-generation sequencing (NGS) in patients with a suspect lesion of the pancreas. The NGS analysis can lead to a change in the treatment plan or supports inconclusive or uncertain cytology results. We describe the advantages of NGS using one particular patient with a recurrent pancreatic lesion 7 years after resection of a pancreatic ductal adenocarcinoma (PDAC). Our NGS analysis revealed the presence of a presumed second primary cancer in the pancreatic remnant, which led to a change in treatment: resection with curative intend instead of palliation...
February 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27624940/selective-assembly-of-na-k-atpase-%C3%AE-2%C3%AE-2-heterodimers-in-the-heart-distinct-functional-properties-and-isoform-selective-inhibitors
#16
Michael Habeck, Elmira Tokhtaeva, Yotam Nadav, Efrat Ben Zeev, Sean P Ferris, Randal J Kaufman, Elizabeta Bab-Dinitz, Jack H Kaplan, Laura A Dada, Zvi Farfel, Daniel M Tal, Adriana Katz, George Sachs, Olga Vagin, Steven J D Karlish
The Na,K-ATPase α2 subunit plays a key role in cardiac muscle contraction by regulating intracellular Ca(2+), whereas α1 has a more conventional role of maintaining ion homeostasis. The β subunit differentially regulates maturation, trafficking, and activity of α-β heterodimers. It is not known whether the distinct role of α2 in the heart is related to selective assembly with a particular one of the three β isoforms. We show here by immunofluorescence and co-immunoprecipitation that α2 is preferentially expressed with β2 in T-tubules of cardiac myocytes, forming α2β2 heterodimers...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27622276/retrospective-comparative-study-of-rigid-and-flexible-ureteroscopy-for-treatment-of-proximal-ureteral-stones
#17
Ehab Mohamad Galal, Ahmad Zaki Anwar, Tarek Khalaf Fath El-Bab, Amr Mohamad Abdelhamid
BACKGROUND: We analyzed the outcome and complications of rigid (R-URS) and flexible (F-URS) ureteroscopic lithotripsy for treatment of proximal ureteric stone (PUS). SUBJECTS AND METHODS: Retrospective data of 135 patients (93 males and 42 females) submitted to R-URS and F-URS for treatment of PUS in the period between July 2013 and January 2015 were investigated. (R-URS, group 1) was performed in 72 patients while 63 patients underwent (F-URS, group 2).We compared the 2 groups for success, stone characteristics, operative time, intraoperative and postoperative complications...
September 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27619080/homolytic-heterolytic-mesolytic-as-you-like-it-steering-the-cleavage-of-a-hc-sp-3-c-sp-3-h-bond-in-bis-1h-2-1-benzazaborole-derivatives
#18
Martin Hejda, Antonín Lyčka, Tomáš Mikysek, Roman Jambor, Aleš Růžička, Jaromír Vinklárek, Claudia Wilfer, Alexander Hoffmann, Sonja Herres-Pawlis, Libor Dostál
A set of (3,3')-bis(1-Ph-2-R-1H-2,1-benzazaborole) compounds, in which R=tBu (Bab-tBu)2 , R=Dipp (Bab-Dipp)2 or R=tBu and Dipp (Bab-Dipp)(Bab-tBu), was synthesized and fully characterized using (1) H, (11) B, (13) C, and (15) N NMR spectroscopy as well as single-crystal X-ray diffraction analysis. The central HC(sp(3) )-C(sp(3) )H bond with restricted rotation at the junction of both 1H-2,1-benzazaborole rings displayed an intriguing reactivity. It was demonstrated that this bond is easily mesolytically cleaved using alkali metals to form the respective aromatic 1Ph-2R-1H-2,1-benzazaborolyl anions M(+) (THF)n (Bab-tBu)(-) (M=Li, Na, K) and K(+) (THF)n (Bab-Dipp)(-) ...
October 17, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27604035/ablation-of-locally-advanced-pancreatic-cancer-with-percutaneous-irreversible-electroporation-results-of-the-phase-i-ii-panfire-study
#19
Hester J Scheffer, Laurien G P H Vroomen, Marcus C de Jong, Marleen C A M Melenhorst, Babs M Zonderhuis, Freek Daams, Jantien A Vogel, Marc G H Besselink, Cornelis van Kuijk, Jill Witvliet, Marian A E de van der Schueren, Tanja D de Gruijl, Anita G M Stam, Petrousjka M P van den Tol, Foke van Delft, Geert Kazemier, Martijn R Meijerink
Purpose To (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate the quality of life (QOL), pain perception, and efficacy in terms of time to local progression, event-free survival, and overall survival (OS). Materials and Methods The study was approved by the local review board (NL42888.029.13). All patients provided written informed consent for study participation, the ablation procedure, and data usage. Between January 2014 and June 2015, 25 patients with histologically proved locally advanced pancreatic cancer 5 cm or smaller (13 women, 12 men; median age, 61 years; age range, 41-78 years) were prospectively included to undergo percutaneous computed tomographic-guided IRE...
February 2017: Radiology
https://www.readbyqxmd.com/read/27591568/interaction-between-amphipathic-triblock-copolymers-and-l-%C3%AE-dipalmitoyl-phosphatidylcholine-large-unilamellar-vesicles
#20
M A Palominos, D Vilches, E Bossel, M A Soto-Arriaza
This study contributes to an understanding of how different polymeric structures, in special triblock copolymers can interact with the lipid bilayer. To study the phospholipid-copolymer vesicles system, we report the effect of two amphipathic triblock copolymers of the type BAB, i.e., hydrophobic-hydrophilic-hydrophobic triblock copolymers arranged as poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) (PCLn-PEOm-PCLn), where n=12 and m=45 for COP1 and n=16 and m=104 for COP2, on the dynamic and structural properties of dipalmitoyl-phosphatidylcholine (DPPC) large unilamellar vesicles (LUVs)...
December 1, 2016: Colloids and Surfaces. B, Biointerfaces
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