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JOURNAL ARTICLE
Saurabh Jain, Adarsh Kumar Shukla, Surbhi Panwar, Rajesh Kumar, Ashwani Kumar
Most of the Escherichia coli turned into serious pathogens or developed antibiotic resistance, mainly due to their ability to show different phenotypic traits. In order to overcome the resistance to these antibiotics, the use of essential oils (EOs) is of great significance against highly pathogenic microorganisms. This study has been made to compare the in vitro antibacterial activity and further validated the same through the molecular docking study of 13 antibiotics such as ciprofloxacin, chloramphenicol, erythromycin, ampicillin, cefotaxime, rifampicin, kanamycin, vancomycin, streptomycin, penicillin, nalidixic acid, trimethoprim, and polymyxin, and 10 EOs such as garlic, tulsi, neem, clove, thyme, peppermint, coriander, tea, lavender, and eucalyptus against the target protein (DNA gyrase) of E...
April 16, 2024: Biotechnology and Applied Biochemistry
#2
JOURNAL ARTICLE
Haojia Li, Ting Zhou, Qi Zhang, Yuwei Yao, Teng Hua, Jun Zhang, Hongbo Wang
Endometrial cancer is considered to be the second most common tumor of the female reproductive system, and patients diagnosed with advanced endometrial cancer have a poor prognosis. The influence of fatty acid metabolism in the prognosis of patients with endometrial cancer remains unclear. We constructed a prognostic risk model using transcriptome sequencing data of endometrial cancer and clinical information of patients from The Cancer Genome Atlas (TCGA) database via least absolute shrinkage and selection operator regression analysis...
April 14, 2024: Biotechnology and Applied Biochemistry
#3
JOURNAL ARTICLE
Hongzhi Yang, Bin Hu, Xichun Wang, Wenjie Chen, Huanbin Zhou
Excessive inflammatory response and oxidative stress (OS) play an important role in the pathogenesis of spinal cord injury (SCI). Balance of inflammation and prevention of OS have been considered an effective strategy for the treatment of SCI. Hyaluronan and proteoglycan link protein 1 (HAPLN1), also known as cartilage link protein, has displayed a wide range of biological and physiological functions in different types of tissues and cells. However, whether HAPLN1 regulates inflammation and OS during SCI is unknown...
April 12, 2024: Biotechnology and Applied Biochemistry
#4
JOURNAL ARTICLE
Yong Fan, Renjie Li, Xuekai Deng, Ming Li, Yu Zhou, Dan Wu, Gang Liu
Osteoarthritis occurs in any joints, and identification in its earlier stages helps to treat the disease and increase the recovery rate. The radiography method and imaging techniques are traditionally used to identify osteoarthritis. But these methods are expensive, and with the complicated steps. Researchers are working toward developing a highly sensitive biosensor in identifying the osteoarthritis biomarker. This research was focused on developing a C-terminal telopeptide of type II collagen (CTX-II) colorimetric sensor with gold nanoparticle (AuNP) for diagnosing osteoarthritis...
April 12, 2024: Biotechnology and Applied Biochemistry
#5
JOURNAL ARTICLE
Kalaivani Aiyasamy, Malathi Ramasamy, Abdurahman Hajinur Hirad, Palanisamy Arulselvan, Ravindran Jaganathan, Jagadeesh Suriyaprakash, Indumathi Thangavelu, Abdullah A Alarfaj
Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In preclinical trials, several lung cancer cell lines and xenografts have demonstrated potential activity with GET. Response rates neared 25% in preclinical trials for non-small cell lung cancer. Here, we describe the one-pot synthesis of GET@ZIF-8 nanocomposites (NCs) in pure water, encapsulating zeolitic imidazolate framework 8 (ZIF-8)...
April 9, 2024: Biotechnology and Applied Biochemistry
#6
JOURNAL ARTICLE
Pengfei Chen, Shichang Kang, Yuling Hu, Tao Pu, Yajun Liu, Shijin Wang, Mukesh Rai, Ke Wang, Lekhendra Tripathee, Chaoliu Li
South and Southeast Asia (SSA) emitted black carbon (BC) exerts potential effects on glacier and snow melting and regional climate change in the Tibetan Plateau. In this study, online BC measurements were conducted for 1 year at a remote village located at the terminus of the Mingyong Glacier below the Meili Snow Mountains. The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) was used to investigate the contribution and potential effect of SSA-emitted BC. In addition, variations in the light absorption characteristics of BC and brown carbon (BrC) were examined...
April 5, 2024: Science of the Total Environment
#7
REVIEW
K E Vivekanandan, R Kasimani, P Vinoth Kumar, S Meenatchisundaram, William Arputha Prabhu
Inflammatory bowel disease (IBD) imposes a significant impact on the quality of life for affected individuals. However, there was a current lack of a systematic summary regarding the latest epidemic trends and the underlying pathogenesis of IBD. This highlights the need for a thorough examination of both the epidemiological aspects of IBD and the specific mechanisms by which lactic acid bacteria (LAB) contribute to mitigating this condition. In developed countries, higher incidences and death rates of IBD have been observed, influenced by a combination of environmental and genetic factors...
April 4, 2024: Biotechnology and Applied Biochemistry
#8
JOURNAL ARTICLE
Emilie Goguet, Cara H Olsen, William A Meyer, Sara Ansari, John H Powers, Tonia L Conner, Si'Ana A Coggins, Wei Wang, Richard Wang, Luca Illinik, Margaret Sanchez Edwards, Belinda M Jackson-Thompson, Monique Hollis-Perry, Gregory Wang, Yolanda Alcorta, Mimi A Wong, David Saunders, Roshila Mohammed, Bolatito Balogun, Priscilla Kobi, Lakeesha Kosh, Kimberly Bishop-Lilly, Regina Z Cer, Catherine E Arnold, Logan J Voegtly, Maren Fitzpatrick, Andrea E Luquette, Francisco Malagon, Orlando Ortega, Edward Parmelee, Julian Davies, Alyssa R Lindrose, Hannah Haines-Hull, Matthew S Moser, Emily C Samuels, Marana S Rekedal, Elizabeth K Graydon, Allison M W Malloy, David R Tribble, Timothy H Burgess, Wesley Campbell, Sara Robinson, Christopher C Broder, Robert J O'Connell, Carol D Weiss, Simon Pollett, Eric D Laing, Edward Mitre
INTRODUCTION: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. METHODS: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants...
2024: Frontiers in Immunology
#9
JOURNAL ARTICLE
Ashish Kumar
The CC chemokine receptor 5 (CCR5) serves a pivotal role in human immunodeficiency virus 1 (HIV-1) infection by acting as a co-receptor and facilitating the binding of the viral envelope glycoprotein (env). Maraviroc (MVC), a Food and Drug Administration-approved monocarboxylic acid amide, is one of the CCR5 inhibitors employed in HIV treatment. Despite the existence of approved drugs, the emergence of drug resistance underscores the necessity for novel compounds to combat resistance and enhance therapeutic efficacy...
March 31, 2024: Biotechnology and Applied Biochemistry
#10
JOURNAL ARTICLE
Gaofang Xiao, Jing Li, Lijun Deng, Shuangquan Gao, Caiyun Tan, Guiqing He, Richang Du
Microsatellite instability (MSI) assessment is strongly recommended for colorectal cancer patients, as MSI status is crucial in determining optimal treatment and predicting prognosis. This study evaluated the reliability and accuracy of a novel polymerase chain reaction (PCR)-based 8-loci MSI test kit, a rapid test kit designed to detect MSI, by comparing its performance with immunohistochemistry (IHC) and the National Cancer Institute (NCI) 2B3D Panel. MSI status was determined in 186 formalin-fixed paraffin-embedded (FFPE) colorectal cancer tissue samples with known mismatch repair (MMR) status by IHC using the novel PCR-based 8-loci MSI test kit...
March 31, 2024: Biotechnology and Applied Biochemistry
#11
JOURNAL ARTICLE
Yao Qu, Huikun Liu, Ting Zhang, Hui Su, Nan Wang, Yue Zhou, Julian Shi, Luyao Wang, Qiyuan Wang, Suixin Liu, Chongshu Zhu, Junji Cao
The 'extreme' emission abatement during the lockdown (from the end of 2019 to the early 2020) provided an experimental period to investigate the corresponding source-specific effects of aerosol. In this study, the variations of source-specific light absorption (babs ) and direct radiative effect (DRE) were obtained during and after the lockdown period by using the artificial neural network (ANN) and source apportionment environmental receptor model. The results showed that the babs decreased for all sources during the two periods...
March 27, 2024: Journal of Environmental Management
#12
JOURNAL ARTICLE
Ramón Arias, Lorena Jiménez, Ana Garzón, Javier Caballero-Villalobos, Bonastre Oliete, Nicolò Amalfitano, Alessio Cecchinato, José M Perea
This study conducted a seasonal analysis of bulk tank milk from 77 sheep farms to establish relationships between the concentration of major microbial groups and milk coagulation properties. The investigated milk traits included composition (pH, fat, casein, lactose), coagulation properties (curd firmness: A60 -, rennet clotting time: RCT-, curd firming time: k20 -, curd yield: CY-), and somatic cell score (SCS). The main microbial groups analyzed were total mesophilic bacteria (SPC), thermodurics (THERMO), psychrotrophs (PSYCHRO), Pseudomonas spp...
March 14, 2024: Foods (Basel, Switzerland)
#13
JOURNAL ARTICLE
Mohammad Mehdi Soltan Dallal, Maryam Siavashi, Samira Karimaei, Vahid Siavashi, Milad Abdi, Mehdi Yaseri, Seyed Alireza Razavi, Ronak Bakhtiari
Sepsis is a potentially fatal syndrome related to severe systemic inflammation developed by infection. Despite different antimicrobial therapies, morbidity and mortality rates remain high. Herbs along with cell therapy have been introduced as a promising option to improve the symptoms of sepsis. The present study aimed to evaluate the therapeutic effect of simultaneous administration of thyme essential oil (TEO) and endothelial progenitor stem cells (EPCs) on lipopolysaccharide (LPS)-induced sepsis in C57BL/6 mice...
March 21, 2024: Biotechnology and Applied Biochemistry
#14
JOURNAL ARTICLE
Dena Najafi, Goli Siri, Maryam Sadri, Omid Yazdani, Romina Esbati, Parvin Karimi, Ali Keshavarz, Amirreza Mehmandar-Oskuie, Mehmet Ilktac
Gastric cancer (GC) is a prominent cause of cancer-related mortality worldwide. Long noncoding RNA (lncRNA) maternal expression gene3 (MEG3) participates in numerous signaling pathways by targeting the miRNA-mRNA axis. Studies on human tumors have demonstrated that the antibiotic Ciprofloxacin induces cell cycle changes, programmed cell death, and growth suppression. In this study, we transfected MEG3 lncRNA and Ciprofloxacin into the MKN-45 GC cell line. qRT-PCR was employed to evaluate the effects on the specific microRNA and mRNA...
March 18, 2024: Biotechnology and Applied Biochemistry
#15
JOURNAL ARTICLE
WenHui Li, Cheng Fang, Ya Gao, Yan Gao, FengShang Yan, BiLiang Chen, MingJuan Xu
Plasma circulating P-selectin glycoprotein ligand-1 (PSGL-1) levels and its clinical correlation in patients with epithelial ovarian cancer (EOC) are unknown. The study determined plasma PSGL-1 levels in EOC patients and investigated its relationship with clinicopathological factors and prognosis. Plasma PSGL-1 levels were measured using ELISA in 69 patients with EOC, 34 patients with benign ovarian cystadenoma, and 36 healthy controls. Subsequently, the relationship between PSGL-1 levels and clinicopathological characteristics of patients, as well as the prognosis of EOC patients, was examined...
March 17, 2024: Biotechnology and Applied Biochemistry
#16
JOURNAL ARTICLE
J J Melo Quintero, G P Saracco, M A Bab
In this work, multilayer films consisting of two strong-anisotropic ferromagnetic layers antiferromagnetically coupled by a nonmagnetic spacer are studied by Monte Carlo simulations. The system is modeled by an Ising-based Hamiltonian that depends on both the intralayer exchange and dipolar constants and on the interlayer exchange constant (IEC). The ground state of the monolayers (null IEC) corresponds to alternate stripe domains with width h defined by the ratio between the exchange and dipolar constants (δ)...
February 2024: Physical Review. E
#17
JOURNAL ARTICLE
Albert Asha, Munusamy Chamundeeswari, Rayappan Mary Nancy Flora, Kuppusamy Ravichandran Preethy
In this research, we propose an environmentally friendly method for producing hematite nanoparticles (H-NPs) from natural hematite ore, focusing on their application as efficient contrast agents in x-ray and computed tomography (CT) imaging for medical purposes. The process involves the reduction of iron oxide within the ore to attain the desired hematite phase, crucial for synthesizing H-NPs. To ensure sustainability, we adopted a Green Chemistry approach, utilizing a combination of carbon soot and limestone for the purification process, thereby achieving eco-conscious production...
March 14, 2024: Biotechnology and Applied Biochemistry
#18
JOURNAL ARTICLE
Parastoo Pourali, Milan Svoboda, Eva Neuhöferová, Volha Dzmitruk, Veronika Benson
The biologically produced gold nanoparticles (AuNPs) are novel carriers with promising use in targeted tumor therapy. Still, there are no studies regarding the efficacy of nanoparticle internalization by cancer and noncancer cells. In this study, AuNPs were produced by Fusarium oxysporum and analyzed by spectrophotometry, transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy (EDS), and Zetasizer. Obtained AuNPs were about 15 nm in size with a zeta potential of -35.8 mV. The AuNPs were added to cancer cells (4T1), noncancer cells (NIH/3T3), and macrophages (RAW264...
March 13, 2024: Biotechnology and Applied Biochemistry
#19
REVIEW
Noor Baiti Bab, Raja Nur Adilah Raja Abdul Rahman, Salina Mohamed, Nawwal Alwani Mohd Radzi, Norashikin Yusof
BACKGROUND: The rising percentage of children and adolescents experiencing mental disorders brought attention to the emerging opportunities for proactive oral health interventions in this population. Currently, existing guidelines focus mainly on oral health in general practice and on adults residing in care homes. This report aims to provide a broad overview of the effectiveness of oral health interventions for children and adolescents with mental disorders. METHOD: This review followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses 2020) statement...
March 13, 2024: Special Care in Dentistry
#20
JOURNAL ARTICLE
Baby Shakila P, Tamilmani Periasamy, Abdullah A Alarfaj, Palanisamy Arulselvan, Rajeswari Ravindran, Jagadeesh Suriyaprakash, Indumathi Thangavelu
Supramolecular nanoparticles containing peptides and drugs have recently gained recognition as an effective tumor treatment drug delivery system. A multitarget drug termed pemetrexed is effective against various cancers, including nonsmall cell lung cancer. The work aims to establish the capability of pemetrexed gold nanoparticles (PEM-AuNPs) to induce apoptosis and explore molecular changes. X-ray diffraction, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, scanning electron microscope, and transmission electron microscope were used to investigate the synthesized nanoparticles...
March 12, 2024: Biotechnology and Applied Biochemistry
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