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Dysarthria

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https://www.readbyqxmd.com/read/29240814/towards-the-identification-of-idiopathic-parkinson-s-disease-from-the-speech-new-articulatory-kinetic-biomarkers
#1
J I Godino-Llorente, S Shattuck-Hufnagel, J Y Choi, L Moro-Velázquez, J A Gómez-García
Although a large amount of acoustic indicators have already been proposed in the literature to evaluate the hypokinetic dysarthria of people with Parkinson's Disease, the goal of this work is to identify and interpret new reliable and complementary articulatory biomarkers that could be applied to predict/evaluate Parkinson's Disease from a diadochokinetic test, contributing to the possibility of a further multidimensional analysis of the speech of parkinsonian patients. The new biomarkers proposed are based on the kinetic behaviour of the envelope trace, which is directly linked with the articulatory dysfunctions introduced by the disease since the early stages...
2017: PloS One
https://www.readbyqxmd.com/read/29237663/progressive-myoclonic-epilepsy-and-horizontal-gaze-palsy-a-rare-aetiology
#2
Rajveer Singh, Aditya Choudhary, Amith S Kumar, Manoj Kumar Goyal
Gaucher's disease is a rare autosomal recessive, potentially fatal disorder but most common type among lysosomal storage disorders. The disease's incidence is around 1/40 000 to 1/60 000 births in the general population. A 32-year-old man, born out of non-consanguineous union, presented with generalised tonic-clonic seizures and myoclonus since 17 years of age. Seizures were noted to be resistant to multiple epileptic drugs. He developed gait imbalance, intentional tremor and dysarthria. Detailed examination revealed hepatosplenomegaly, bilateral pancerebellar signs with normal power, reflexes and sensory system...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29229347/post-operative-stridor-and-acute-respiratory-failure-after-parkinson-s-disease-deep-brain-stimulator-placement-a-case-report-and-review-of-literature
#3
Mi Wang, Wael Saasouh, Thomas Botsford, Allen Keebler, Andrew Zura, Michael S Benninger, Rafi Avitsian
BACKGROUND: Parkinson's disease (PD), a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra of the midbrain is commonly thought of as a motion disorder, but it can have significant effect on the respiratory system. Respiratory failure is the most common cause of death in these patients, but it can also affect laryngeal function causing dysphonia, dysphagia, and dysarthric speech.. Acute upper airway obstruction is a very rare finding in PD, especially in the perioperative settings...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29225339/early-speech-development-in-koolen-de-vries-syndrome-limited-by-oral-praxis-and-hypotonia
#4
Angela T Morgan, Leenke van Haaften, Karen van Hulst, Carol Edley, Cristina Mei, Tiong Yang Tan, David Amor, Simon E Fisher, David A Koolen
Communication disorder is common in Koolen de Vries syndrome (KdVS), yet its specific symptomatology has not been examined, limiting prognostic counselling and application of targeted therapies. Here we examine the communication phenotype associated with KdVS. Twenty-nine participants (12 males, 4 with KANSL1 variants, 25 with 17q21.31 microdeletion), aged 1.0-27.0 years were assessed for oral-motor, speech, language, literacy, and social functioning. Early history included hypotonia and feeding difficulties...
December 11, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29221912/variable-clinical-phenotype-in-two-siblings-with-aicardi-gouti%C3%A3-res-syndrome-type-6-and-a-novel-mutation-in-the-adar-gene
#5
Lisa Schmelzer, Martin Smitka, Christine Wolf, Nadja Lucas, Victoria Tüngler, Gabriele Hahn, Andreas Tzschach, Nataliya Di Donato, Min Ae Lee-Kirsch, Maja von der Hagen
Aicardi-Goutières syndrome (AGS) is a hereditary inflammatory encephalopathy resulting in severe neurological damage in the majority of cases. We report on two siblings with AGS6 due to compound heterozygosity for a known and a novel mutation in the ADAR gene and a strikingly variable phenotype. The first sibling presented at 12 months of age with a subacute encephalopathy following a mild respiratory infection. The child developed a spastic tetraparesis, generalized dystonia and dysarthria. In contrast, the younger sibling presented with an acute episode of neurological impairment in his third year of life, from which he recovered without sequelae within a few weeks...
November 22, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29214039/clinical-and-genetic-analysis-of-spinocerebellar-ataxia-type-7-sca7-in-zambian-families
#6
Masharip Atadzhanov, Danielle C Smith, Mwila H Mwaba, Omar K Siddiqi, Alan Bryer, L Jacquie Greenberg
Background: To date, 43 types of Spinocerebellar Ataxias (SCAs) have been identified. A subset of the SCAs are caused by the pathogenic expansion of a CAG repeat tract within the corresponding gene. Ethnic and geographic differences are evident in the prevalence of the autosomal dominant SCAs. Few descriptions of the clinical phenotype and molecular genetics of the SCAs are available from the African continent. Established studies mostly concern the South African populations, where there is a high frequency of SCA1, SCA2 and SCA7...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29209698/articulatory-kinematic-characteristics-across-the-dysarthria-severity-spectrum-in-individuals-with-amyotrophic-lateral-sclerosis
#7
Jimin Lee, Michael Bell, Zachary Simmons
Purpose: The current study investigated whether articulatory kinematic patterns can be extrapolated across the spectrum of dysarthria severity in individuals with amyotrophic lateral sclerosis (ALS). Method: Temporal and spatial articulatory kinematic data were collected using electromagnetic articulography from 14 individuals with dysarthria secondary to ALS and 6 typically aging speakers. Speech intelligibility and speaking rate were used as indices of severity...
December 6, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29205054/best-practices-protocol-for-the-evaluation-of-bulbar-dysfunction-summary-recommendations-from-the-neals-bulbar-subcommittee-symposium
#8
Gary L Pattee, Emily K Plowman, Benjamin R Brooks, James D Berry, Nazem Atassi, Jennifer L Chapin, Kendrea Garand, Yana Yunusova, Courtney E Mcilduff, Eufrosina Young, John M Costello, Eric A Macklin, Eduardo R Locatelli, Vincenzo Silani, Daragh Heitzman, James Wymer, Stephen A Goutman, Deborah F Gelinas, Richard Smith, Bridget Perry, Paige Nalipinski, Kaila Stipancic, Meghan O'Brien, Stacey L Sullivan, Jordan Green
OBJECTIVE: The aim of this Symposium was to develop a consensus based, bulbar assessment protocol for implementation within NEALS clinics. METHODS: A one-day symposium, held in April 2017, was organized into Speech and Swallowing sections to establish summary recommendations for the assessment of bulbar dysfunction within each group. RESULTS: Summary recommendations included speech referrals and AAC evaluations at initial visit, CNS-BFS, maximum sustained phonation, and speaking rate...
December 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29204601/receptive-vocabulary-cognitive-flexibility-and-inhibitory-control-differentially-predict-older-and-younger-adults-success-perceiving-speech-by-talkers-with-dysarthria
#9
Erin M Ingvalson, Kaitlin L Lansford, Valeriya Fedorova, Gabriel Fernandez
Purpose: Previous research has demonstrated equivocal findings related to the effect of listener age on intelligibility ratings of dysarthric speech. The aim of the present study was to investigate the mechanisms that support younger and older adults' perception of speech by talkers with dysarthria. Method: Younger and older adults identified words in phrases produced by talkers with dysarthria. Listeners also completed assessments on peripheral hearing, receptive vocabulary, and executive control functions...
December 4, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29201851/postoperative-subarachnoid-hemorrhage-and-multipunctate-intracerebral-hemorrhages-following-evacuation-of-bilateral-chronic-subdural-hematomas
#10
Won-Bae Seung, Ju Ho Jeong
Chronic subdural hematoma (CSDH) can be easily treated by burr hole surgery. However, several complications including intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and acute subdural hematoma are rare after evacuation of a CSDH. A 77-year-old man was admitted with right hemiparesis and dysarthria. A brain computed tomography (CT) scan revealed a bilateral CSDH with midline shifting toward the right side. The patient got the burr hole trephination with the catheters insertion in the both sides of parietal area under the local anesthesia...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29201128/a-highlighted-case-for-emphasizing-on-clinical-diagnosis-for-rare-syndrome-in-third-world
#11
Fatemeh Owlia, Mohammad-Hassan Akhavan Karbassi, Roqayeh Hakimian, Mohammad Sadegh Alemrajabi
Premature tooth loss is a disastrous situation that affects deciduous or permanent teeth era with different causes. It may be attributed to some disorders like Papillon-Lefevre syndrome or coffin-lowry syndrome but because of ambiguous nature, precise diagnosis is not easily possible. Moreover, it has very low incidence and defines by few and limited case series, with vague characters to some extent, confusion in detecting the right diagnosis is a common possibility. Hence, it is expectable to have a wrong diagnosis for this case...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29200254/-lack-of-knowledge-is-no-excuse-hiv-positive-patient-with-progressive-multifocal-leukoencephalopathy-case-report-from-kenya
#12
(no author information available yet)
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease that affects the central nervous system, which has high morbidity and mortality and no effective, targeted therapies are available. According to the data from developing countries, it affects about 3 to 5% patients who are HIV positive. We present a case of a 27-year-old patient, who got infected with the HIV virus from his mother. The patient had poor compliance to the therapy since its initiation. Due to poor compliance and immunological and virological failure of the first line ARVs, the patient developed PML...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29196364/lesson-of-the-month-2-use-of-thrombolysis-for-ischaemic-stroke-in-pregnancy-a-case-report-and-review-of-literature
#13
Asim Khan, Paris Hosseini, Branimir Nevajda, Sami Khan
A nine-week pregnant 33-year-old female presented with sudden-onset right-sided hemiparesis, hemisensory loss, dysarthria and homonymous hemianopia. She was known to have eleven previous miscarriages and used recreational drugs. A CT-head was unremarkable. The patient was subsequently diagnosed with an acute thromboembolic infarct and chose alteplase after counselling. During thrombolysis an ultrasound identified a foetus with no concerning features.  A post-thrombolysis CT revealed a left-sided posterior cerebral infarct...
December 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29196249/deep-brain-stimulation-for-essential-tremor-a-comparison-of-targets
#14
Joost A H Holslag, Nienke Neef, Martijn Beudel, Gea Drost, D L Marinus Oterdoom, Naomi I Kremer, Teus van Laar, J Marc C van Dijk
INTRODUCTION: Deep Brain Stimulation (DBS) is an established treatment for refractory Essential Tremor (ET). Initially, the target of choice was the thalamic Ventral Inter Mediate nucleus (VIM). However, the Zona Incerta (ZI) has been put forward as a superior target. Both targets are considered safe and effective, but a direct comparison between these targets is lacking. METHODS: We analyzed a single-center cohort of 44 ET-patients treated with DBS between 1998 and 2017, targeting the VIM and/or ZI...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29191439/effects-of-cerebellar-neuromodulation-in-movement-disorders-a%C3%A2-systematic-review
#15
REVIEW
Carina França, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Ricardo Galhardoni, Valquiria Silva, Egberto Reis Barbosa, Rubens Gisbert Cury
BACKGROUND: The cerebellum is involved in the pathophysiology of many movement disorders and its importance in the field of neuromodulation is growing. OBJECTIVES: To review the current evidence for cerebellar modulation in movement disorders and its safety profile. METHODS: Eligible studies were identified after a systematic literature review of the effects of cerebellar modulation in cerebellar ataxia, Parkinson's disease (PD), essential tremor (ET), dystonia and progressive supranuclear palsy (PSP)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29190627/gender-related-differences-and-short-term-outcome-of-stroke-results-from-a-hospital-based-registry-in-sub-saharan-africa
#16
Yacouba Njankouo Mapoure, Ngowo Lydia Eyambe, Anastase Tamdja Dzudie, Chia Mark Ayeah, Hamadou Ba, Romuald Hentchoya, Henry Namme Luma
BACKGROUND: Studies suggest that sex differences have an impact on patients with stroke, but existing data in Africa remain inconclusive about this inference. OBJECTIVES: To study sex differences in terms of the clinical profile and short-term outcome of stroke in the Douala General Hospital, Cameroon. METHODS: A hospital-based prospective cohort study was carried out in a tertiary care hospital over an 8-year period, which included all patients admitted for confirmed acute stroke...
November 30, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29187691/-tapia-s-syndrome-following-transesophageal-echocardiography-during-an-open-heart-operation-a-case-report
#17
Satoru Fujiwara, Hajime Yoshimura, Kenta Nishiya, Keiichi Oshima, Michi Kawamoto, Nobuo Kohara
A 67-year-old man presented with hoarseness, dysarthria and deviation of the tongue to the left side the day after the open-heart operation under general anesthesia. Brain MRI demonstrated no causal lesion, and laryngoscope showed left vocal cord abductor palsy, so we diagnosed him with Tapia's syndrome (i.e., concomitant paralysis of the left recurrent and hypoglossal nerve). His neurological symptoms recovered gradually and improved completely four months after the onset. Tapia's syndrome is a rare condition caused by the extra cranial lesion of the recurrent laryngeal branch of the vagus nerve and the hypoglossal nerve, and mostly described as a complication of tracheal intubation...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29187688/-progressive-dysarthria-and-bilateral-sensory-disturbance-in-a-case-of-bilateral-ventrolateral-pontine-infarction
#18
Soichiro Abe, Shuhei Okazaki, Shuichi Tonomura, Kotaro Miyashita, Masafumi Ihara
A rare case of bilateral ventrolateral pontine infarction in a 70-year-old man who developed progressive dysarthria and bilateral sensory disturbance is reported with literature review. He had been diagnosed with hypertension, dyslipidemia, and impaired glucose tolerance 10 years earlier. Ten days before admission, he was aware of the difficulty in walking and speaking, which gradually worsened. On admission he showed bilateral thermal hypoalgesia of face and lower extremities, dysarthria, dysphagia, and ataxic gait...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29187683/-efficacy-of-high-dose-steroid-pulse-therapy-for-anti-galactocerebroside-antibody-positive-combined-central-and-peripheral-demyelination
#19
Masashi Hoshino, Yu Suzuki, Hisanao Akiyama, Kouji Yamada, Sayuri Shima, Tatsuro Mutoh, Yasuhiro Hasegawa
A 59-year-old man had been admitted to another hospital because of diplopia and thirst at the beginning of March and was diagnosed with diabetic ketoacidosis. He was referred to our hospital because he had limb weakness, dysarthria, and bilateral sensory impairment of the upper limbs, which worsened rapidly from the middle of March, although plasma glucose had been well controlled after the initiation of insulin therapy in the previous hospital. Contrast spinal MRI in our hospital revealed hyperintense lesions at the level of C4 to C5 and T10...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29184336/speech-signal-analysis-and-pattern-recognition-in-diagnosis-of-dysarthria
#20
Minu George Thoppil, C Santhosh Kumar, Anand Kumar, John Amose
Background: Dysarthria refers to a group of disorders resulting from disturbances in muscular control over the speech mechanism due to damage of central or peripheral nervous system. There is wide subjective variability in assessment of dysarthria between different clinicians. In our study, we tried to identify a pattern among types of dysarthria by acoustic analysis and to prevent intersubject variability. Objectives: (1) Pattern recognition among types of dysarthria with software tool and to compare with normal subjects...
October 2017: Annals of Indian Academy of Neurology
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