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lanthanum carbonate

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https://www.readbyqxmd.com/read/29137107/effect-of-lanthanum-carbonate-on-coronary-artery-calcification-and-bone-mineral-density-in-maintenance-hemodialysis-patients-with-diabetes-complicated-with-adynamic-bone-disease-a-prospective-pilot-study
#1
Chunhua Zhang, Shixiang Wang, Sumei Zhao, Xiaodong Zhang
BACKGROUND: The incidence of adynamic bone disease (ABD) is increasing. Coronary artery calcification (CAC) may be severe in patients with ABD on maintenance hemodialysis (MHD). The aim of this study was to evaluate the effect of lanthanum carbonate (LC) on CAC and bone mineral density (BMD) in MHD patients with diabetes complicated with ABD. METHODS: A total of 92 MHD cases were divided into the calcium carbonate (CC) and LC groups. Primary outcome measure was the changes in the degree of CAC score (CACS) and BMD in forearm from baseline to 12 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29058057/effects-of-lanthanum-carbonate-on-coronary-artery-calcification-and-cardiac-abnormalities-after-initiating-hemodialysis
#2
Hideki Fujii, Keiji Kono, Kentaro Nakai, Shunsuke Goto, Tatsuya Nishii, Atsushi Kono, Shinichi Nishi
It is known that calcium-containing phosphate binders are more closely associated with the progression of vascular calcification than non-calcium-containing phosphate binders. In this study, we investigated the effect of the non-calcium-containing phosphate binder, lanthanum carbonate on the progression of coronary artery calcification and cardiovascular abnormalities compared to that of calcium-containing phosphate binder in chronic kidney disease patients during the early period after initiating hemodialysis...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28976178/thermally-stable-and-electrically-conductive-vertically-aligned-carbon-nanotube-silicon-infiltrated-composite-structures-for-high-temperature-electrodes
#3
Qi Ming Zou, Lei Min Deng, Da Wei Li, Yun Shen Zhou, Hossein Rabiee Golgir, Kamran Keramatnejad, Li Sha Fan, Lan Jiang, Jean-Francois Silvain, Yong Feng Lu
Traditional ceramic-based, high-temperature electrode materials (e.g., lanthanum chromate) are severely limited due to their conditional electrical conductivity and poor stability under harsh circumstances. Advanced composite structures based on vertically aligned carbon nanotubes (VACNTs) and high-temperature ceramics are expected to address this grand challenge, in which ceramic serves as a shielding layer protecting the VACNTs from the oxidation and erosive environment, while the VACNTs work as a conductor...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28948987/on-the-interfacial-charge-transfer-between-solid-and-liquid-li-electrolytes
#4
Marco Schleutker, Jochen Bahner, Chih-Long Tsai, Detlef Stolten, Carsten Korte
The Li(+) ion transfer between a solid and a liquid Li(+) electrolyte has been investigated by DC polarisation techniques. The current density i is measured as a function of the electrochemical potential drop Δ[small mu, Greek, tilde]Li(+) at the interface, using a liquid electrolyte with different Li(+) concentrations. The subject of this experimental study is the interface between the solid electrolyte Ta-substituted lithium lanthanum zirconate (Li6.6La3Zr1.6Ta0.4O12) and a liquid electrolyte consisting of LiPF6 dissolved in ethylene carbonate/dimethyl carbonate (1 : 1)...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28904356/extremely-high-electrical-conductance-of-microporous-3d-graphene-like-zeolite-templated-carbon-framework
#5
Hyunsoo Lee, Kyoungsoo Kim, Seoung-Hun Kang, Yonghyun Kwon, Jong Hun Kim, Young-Kyun Kwon, Ryong Ryoo, Jeong Young Park
We report the remarkably high electrical conductance of microporous 3D graphene-like carbons that were formed using lanthanum (La)-catalyzed synthesis in a Y zeolite (LaY) template investigated using conductive atomic force microscopy (C-AFM) and theoretical calculations. To uncover the relation between local electrical conductance and the microporous structures, we tuned the crystallographic ordering of LaY-templated carbon systems by changing the heating temperature. The structure of the LaY-templated carbon prepared at the higher temperature has graphene-like sp (2) hybridized bonds, which was confirmed using high-resolution transmission electron microscopy and X-ray diffraction measurements...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810759/lanthanum-mediated-dehydrogenation-of-1-and-2-butynes-spectroscopy-and-formation-of-la-c4h4-isomers
#6
Wenjin Cao, Dilrukshi Hewage, Dong-Sheng Yang
La atom reactions with 1-butyne and 2-butyne are carried out in a laser-vaporization molecular beam source. Both reactions yield the same La-hydrocarbon products from the dehydrogenation and carbon-carbon bond cleavage and coupling of the butynes. The dehydrogenated species La(C4H4) is characterized with mass-analyzed threshold ionization (MATI) spectroscopy and quantum chemical computations. The MATI spectra of La(C4H4) produced from the two reactions exhibit two identical transitions, each consisting of a strong origin band and several vibrational intervals...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28799264/correlation-of-lanthanum-dosage-with-lanthanum-deposition-in-the-gastroduodenal-mucosa-of-dialysis-patients
#7
Kimiaki Hattori, Tamaki Maeda, Shinya Nishida, Miyuki Imanishi, Masahiro Sakaguchi, Yoshifumi Amari, Takuya Moriya, Yoshinobu Hirose
Lanthanum (La) deposition has been observed in gastrointestinal mucosa of dialysis patients treated with La carbonate to treat hyperphosphatemia in the 6 years since its authorization in Japan. We investigated gastrointestinal biopsies from 112 dialysis patients, and found 15 cases of histiocytic aggregation with crystalloids and one case of duodenitis with histiocyte aggregation without crystalloids in the 30 patients treated with La carbonate. No histiocytic lesions were observed in the 82 patients without La carbonate administration...
August 11, 2017: Pathology International
https://www.readbyqxmd.com/read/28781325/clinical-characteristics-of-seven-patients-with-lanthanum-phosphate-deposition-in-the-stomach
#8
Naoko Murakami, Masao Yoshioka, Masaya Iwamuro, Junichirou Nasu, Soichiro Nose, Junji Shiode, Hiroyuki Okada, Kazuhide Yamamoto
Objective To analyze the clinical characteristics and endoscopic features of patients with lanthanum deposition in the stomach. Patients We retrospectively reviewed seven patients with lanthanum deposition in the stomach who were diagnosed at Okayama Saiseikai General Hospital. We investigated the patient sex, age at diagnosis, medical and medication histories, gastrointestinal symptoms, complications, presence or absence of gastric atrophy, and outcome. We also investigated any changes in the endoscopic features if previous endoscopic images were available...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28752824/the-feasibility-of-in-vivo-detection-of-lanthanum-using-a-241-am-k-x-ray-fluorescence-system
#9
Joanna Nguyen, Zaid Keldani, Eric Da Silva, Ana Pejović-Milić, James L Gräfe
OBJECTIVE: Lanthanum (La) is commonly used in phosphate binders in the form of lanthanum carbonate in patients with end-stage kidney disease undergoing hemodialysis treatments. With this administration, there is the potential for La storage in the body with bone being the main site of concern. However, the long-term effects of residual La in the body on bone health are not yet known. In this work, we investigate the feasibility of using a K x-ray fluorescence (K-XRF) spectroscopy system to measure bone La in vivo...
August 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28717990/iron-based-phosphate-binders-a-paradigm-shift-in-the-treatment-of-hyperphosphatemic-anemic-ckd-patients
#10
REVIEW
Francesco Locatelli, Lucia Del Vecchio
The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling hypertension and partially correcting anemia. Unfortunately, the treatment of hyperphosphatemia is still far from resolved. Phosphate binders have poor tolerability and/or limited efficacy, leading to the prescription of many tablets that achieve only a mild-to-moderate effect...
July 17, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28704404/pa21-a-novel-phosphate-binder-improves-renal-osteodystrophy-in-rats-with-chronic-renal-failure
#11
COMPARATIVE STUDY
Atsushi Yaguchi, Satoshi Tatemichi, Hiroo Takeda, Mamoru Kobayashi
The effects of PA21, a novel iron-based and non-calcium-based phosphate binder, on hyperphosphatemia and its accompanying bone abnormality in chronic kidney disease-mineral and bone disorder (CKD-MBD) were evaluated. Rats with adenine-induced chronic renal failure (CRF) were prepared by feeding them an adenine-containing diet for four weeks. They were also freely fed a diet that contained PA21 (0.5, 1.5, and 5%), sevelamer hydrochloride (0.6 and 2%) or lanthanum carbonate hydrate (0.6 and 2%) for four weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28675980/a-combined-deposition-of-lanthanum-and-%C3%AE-2-microglobulin-related-amyloid-in-the-gastroduodenal-mucosa-of-hemodialysis-dependent-patients-an-immunohistochemical-electron-microscopic-and-energy-dispersive-x-ray-spectrometric-analysis
#12
Takayoshi Komatsu-Fujii, Hideyuki Onuma, Youichi Miyaoka, Noriyoshi Ishikawa, Asuka Araki, Nahoko Ishikawa, Tomohiko Yamamoto, Tomoko Mishiro, Kyoichi Adachi, Yoshikazu Kinoshita, Pamela Tauchi-Nishi, Riruke Maruyama
Lanthanum carbonate (LC) is a new type of phosphate adsorbent used to treat patients with hyperphosphatemia caused by chronic kidney diseases. Recent studies have pointed out that lanthanum deposition can be found in the cytoplasm of histiocytes in the gastroduodenal mucosa of these patients. On the other hand, it is well known that patients on long-term hemodialysis can develop deposition of β2-microglobulin-related amyloid (Aβ2M) mainly around joints. However, involvement of the gastrointestinal tract by hemodialysis-associated amyloidosis has been thought to be rare, and therefore only Aβ2M, if any, has been reported to accumulate in the vascular walls of the submucosa and muscularis propria...
July 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28660726/gastric-lanthanosis-lanthanum-deposition-in-dialysis-patients-treated-with-lanthanum-carbonate
#13
Yuki Shitomi, Haruto Nishida, Takahiro Kusaba, Tsutomu Daa, Shinji Yano, Motoki Arakane, Yoshiyuki Kondo, Takayuki Nagai, Takashi Abe, Ayako Gamachi, Kazunari Murakami, Tsuyoshi Etoh, Norio Shiraishi, Masafumi Inomata, Shigeo Yokoyama
Lanthanum carbonate (LaC) is used to prevent hyperphosphatemia in dialysis patients. It is commonly believed that there is little LaC absorption from the intestines. However, La deposition in the gastric mucosa, which we coined "gastric lanthanosis", was recently reported. We describe here the clinicopathological features of and a possible mechanism for gastric lanthanosis. This study included 23 patients with definite gastric lanthanosis. We extracted characteristic clinicopathological features of gastric lanthanosis by computed tomography (CT) imaging and endoscopic, histologic, electron-microscopic, and element analysis examinations...
June 28, 2017: Pathology International
https://www.readbyqxmd.com/read/28616234/all-that-glitters-is-not-gold-a-case-of-lanthanum-carbonate-aspiration
#14
Suchitra Paranji, Neethi Paranji, Adam S Weltz
INTRODUCTION: Foreign body aspiration is a significant cause of morbidity and mortality in elderly hospitalized patients. These are typically small items that patients have access to, including small coins. CASE PRESENTATION: This is a case report of a 75-year-old man recently bedridden from a large hemispheric stroke with sudden onset of hoarseness, cough and dysphagia. A chest X-ray was obtained which showed a radiopaque coin-shaped foreign body, presumably a coin in his aerodigestive tract...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28598575/an-efficient-and-versatile-lanthanum-heteroscorpionate-catalyst-for-carbon-dioxide-fixation-into-cyclic-carbonates
#15
Javier Martínez, Juan Fernández-Baeza, Luis F Sánchez-Barba, José A Castro-Osma, Agustín Lara-Sánchez, Antonio Otero
A new lanthanum heteroscorpionate complex has shown exceptional catalytic activity for the synthesis of cyclic carbonates from epoxides and carbon dioxide. This catalyst system also promotes the reaction of bio-based epoxides to give an important class of bis(cyclic carbonates) that can be further used for the production of bio-derived non-isocyanate polyurethanes. The catalytic process requires low catalyst loading and mild reaction conditions for the synthesis of a wide range of cyclic carbonates.
July 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28584909/a-review-of-phosphate-binders-in-chronic-kidney-disease-incremental-progress-or-just-higher-costs
#16
REVIEW
Wendy L St Peter, Lori D Wazny, Eric Weinhandl, Katie E Cardone, Joanna Q Hudson
As kidney disease progresses, phosphorus retention also increases, and phosphate binders are used to treat hyperphosphatemia. Clinicians prescribe phosphate binders thinking that reducing total body burden of phosphorus may decrease risks of mineral and bone disorder, fractures, cardiovascular disease, progression of kidney disease, and mortality. Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders. However, studies included in meta-analyses show significant heterogeneity, and exclusion or inclusion of specific studies alters results...
July 2017: Drugs
https://www.readbyqxmd.com/read/28486924/lanthanum-carbonate-a-new-phosphate-binding-drug-in-advanced-renal-failure
#17
Jan Aaseth, Anne-Lise Bjørke-Monsen
Lanthanum (La) is considered to be a non-essential element. La has been used for several decades in China to improve yield in plant production and has also been shown to have significant performance enhancing effects in feeding trials on animal husbandry. The estimated dietary intake of La in humans is below 150 µg, which is lower than 10% of the estimated limit of safe and acceptable daily intake. Upon ingestion of La as carbonate the lanthanum ion (La3+) is released in the stomach and traps dietary phosphate as insoluble lanthanum phosphate complexes in the gut, thereby inhibiting phosphate absorption...
May 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28480713/a-detailed-molecular-dynamics-simulation-and-experimental-investigation-on-the-interfacial-bonding-mechanism-of-an-epoxy-adhesive-on-carbon-steel-sheets-decorated-with-a-novel-cerium-lanthanum-nanofilm
#18
Ghasem Bahlakeh, Bahram Ramezanzadeh
The influences of steel surface treatment by a novel cerium-lanthanum (Ce-La) nanofilm on the adhesion mechanism of an epoxy adhesive were studied through experimental and modeling approaches. The surface morphology and microstructure of the film deposited were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). The surface free energy and work of adhesion values were evaluated through contact angle analysis...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28464802/phosphate-binders-affect-vitamin-k-concentration-by-undesired-binding-an-in-vitro-study
#19
A Neradova, S P Schumacher, I Hubeek, P Lux, L J Schurgers, M G Vervloet
BACKGROUND: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders could limit bioavailability of vitamin K2 by undesired binding. Vitamin K-deficiency limits activation of the vascular tissue mineralization inhibitor matrix γ-carboxyglutamate (Gla) protein (MGP) thereby exacerbating vascular calcification...
May 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28290356/a-case-of-lanthanum-carbonate-ingestion-thought-to-be-phlebosclerotic-colitis-on-ct-imaging-and-abdominal-radiograph
#20
K Harris, S Balcam
A male admitted in the early hours of the morning, complained of a four week, right sided, non-radiating, dull and intermittent abdominal pain. Imaging suggested a diagnosis of phlebosclerotic colitis which was later discounted when the patients' history of lanthanum carbonate ingestion was examined. Phlebosclerotic colitis mostly affects the Asian population, and its cause is still not known, but can be associated with specific radiographic features. Collections of lanthanum may confuse a diagnosis of phlebosclerotic colitis as well as other factors such as voxel errors, photon starvation and movement...
February 2017: Radiography
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