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https://www.readbyqxmd.com/read/28723917/evidence-base-and-practice-variation-in-acute-care-processes-for-knee-and-hip-arthroplasty-surgeries
#1
Marcel Mayer, Justine Naylor, Ian Harris, Helen Badge, Sam Adie, Kathryn Mills, Joseph Descallar
BACKGROUND: Lack of evidence contributes to unnecessary variation in treatment costs and outcomes. This study aimed to identify from interventions historically used for total knee or hip arthroplasty (TKA, THA): i) if routine use is supported by high-level evidence; ii) whether surgeon use aligns with the evidence. METHODS: Part 1: Systematic search of electronic library databases for systematic reviews and practice guidelines concerning seven acute-care interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28723588/shared-decision-making-with-parents-of-acutely-ill-children-a-narrative-review
#2
REVIEW
Paul L Aronson, Eugene D Shapiro, Linda M Niccolai, Liana Fraenkel
BACKGROUND: Shared decision-making (SDM) has mostly been used with adults and parents in the primary care setting, and there is limited knowledge on the use of SDM with parents of acutely ill children. OBJECTIVE: To review the literature on SDM with parents in the management of acutely ill children. DATA SOURCES: We searched MEDLINE, SCOPUS, PsycINFO, the Cochrane Library, and ClinicalTrials.gov for English language studies published from the time of database inception to February, 2017...
July 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28723151/fusion-of-structure-and-ligand-based-methods-for-identification-of-novel-cdk2-inhibitors
#3
Priya Mahajan, Gousia Chashoo, Monika Gupta, Amit Kumar, Parvinder Pal Singh, Amit Nargotra
Cyclin dependent kinases plays a central role in cell cycle regulation which makes them a promising target with multifarious therapeutic potential. CDK2 regulates various events of the eukaryotic cell division cycle and the pharmacological evidences indicated that over expression of CDK2 causes abnormal cell-cycle regulation, which was directly associated with hyper proliferation of cancer cells. Therefore, CDK2 is regarded as a potential target molecule for anti-cancer medication. Thus to decline CDK2 activity by potential lead compounds has proved to be an effective treatment for cancer...
July 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28721545/is-topiramate-effective-for-migraine-prevention-in-patients-less-than-18%C3%A2-years-of-age-a-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali, Yijing Guo
BACKGROUND: Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age. In this meta-analysis, we aimed to assess the currently published data pertaining to the efficacy of topiramate for migraine prevention in patients less than 18 years of age. METHODS: We searched PubMed/Medline, Embase and the Cochrane Library (from inception to April 2017) for randomized controlled trials (RCTs) published in English...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28721115/online-nutrition-and-t2dm-continuing-medical-education-course-launched-on-state-level-medical-association
#5
Kristen K Hicks, Peter S Murano
OBJECTIVE: The purpose of this research study was to determine whether a 1-hour online continuing medical education (CME) course focused on nutrition for type 2 diabetes would result in a gain in nutrition knowledge by practicing physicians. METHODS: A practicing physician and dietitian collaborated to develop an online CME course (both webinar and self-study versions) on type 2 diabetes. This 1-hour accredited course was launched through the state-level medical association's education library, available to all physicians...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28720617/protocol-for-an-online-randomised-controlled-trial-to-evaluate-the-clinical-and-cost-effectiveness-of-a-peer-supported-self-management-intervention-for-relatives-of-people-with-psychosis-or-bipolar-disorder-relatives-education-and-coping-toolkit-react
#6
Fiona Lobban, Heather Robinson, Duncan Appelbe, Johanna Barraclough, Emma Bedson, Lizzie Collinge, Susanna Dodd, Sue Flowers, Mahsa Honary, Sonia Johnson, Ceu Mateus, Barbara Mezes, Valerie Minns, Elizabeth Murray, Andrew Walker, Paula Williamson, Catherine Wintermeyer, Steven Jones
INTRODUCTION: Despite clinical guidelines recommendations, many relatives of people with psychosis or bipolar disorder do not currently receive the support they need. Online information and support may offer a solution. METHODS AND ANALYSIS: This single-blind, parallel, online randomised controlled trial will determine clinical and cost-effectiveness of the Relatives Education And Coping Toolkit (REACT) (including an online resource directory (RD)), compared with RD only, for relatives of people with psychosis or bipolar disorder...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28720369/metabolic-work-up-of-patients-with-urolithiasis-indications-and-diagnostic-algorithm
#7
REVIEW
Hans-Göran Tiselius, Michel Daudon, Kay Thomas, Christian Seitz
CONTEXT: The incidence of urinary tract stone disease is increasing and the risk of recurrent stone formation is high. Appropriate therapeutic procedures with the aim of counteracting the progress of stone formation are highly desirable. Metabolic work-up is considered essential as a base for optimal design and follow-up of effective recurrence prevention. OBJECTIVE: To scrutinize the current literature with regard to principles of metabolic work-up for this heterogeneous group of patients...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28720364/medical-expulsive-therapy-in-urolithiasis-a-review-of-the-quality-of-the-current-evidence
#8
REVIEW
Andreas Skolarikos, Khurshid R Ghani, Christian Seitz, Brandon Van Asseldonk, Matthew F Bultitude
CONTEXT: Medical expulsive therapy (MET) is widely used to promote spontaneous passage of urinary stones. However, there is conflicting evidence on the actual role of MET. OBJECTIVE: To evaluate the conformance of published randomized controlled trials (RCTs) on MET with the Consolidated Standards for Reporting Trials (CONSORT) criteria, and to clarify the current role of MET in management of urinary stones on the basis of our findings. EVIDENCE ACQUISITION: We carried out an electronic search of the Cochrane Library, PubMed, and Embase databases for RCTs on MET...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28718878/deep-brain-and-cortical-stimulation-for-epilepsy
#9
REVIEW
Mathieu Sprengers, Kristl Vonck, Evelien Carrette, Anthony G Marson, Paul Boon
BACKGROUND: Despite optimal medical treatment, including epilepsy surgery, many epilepsy patients have uncontrolled seizures. Since the 1970s interest has grown in invasive intracranial neurostimulation as a treatment for these patients. Intracranial stimulation includes both deep brain stimulation (DBS) (stimulation through depth electrodes) and cortical stimulation (subdural electrodes). This is an updated version of a previous Cochrane review published in 2014. OBJECTIVES: To assess the efficacy, safety and tolerability of DBS and cortical stimulation for refractory epilepsy based on randomized controlled trials (RCTs)...
July 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28716994/diagnosis-and-management-of-perinatal-depression-and-anxiety-in-general-practice-a-meta-synthesis-of-qualitative-studies
#10
Elizabeth Ford, Suzanne Lee, Judy Shakespeare, Susan Ayers
BACKGROUND: Up to 20% of women experience anxiety and depression during the perinatal period. In the UK, management of perinatal mental health falls under the remit of GPs. AIM: This review aimed at synthesising the available information from qualitative studies on GPs' attitudes, recognition, and management of perinatal anxiety and depression. DESIGN AND SETTING: Meta-synthesis of the available published qualitative evidence on GPs' recognition and management of perinatal anxiety and depression...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28716059/major-adverse-cardiac-events-and-mortality-in-chronic-obstructive-pulmonary-disease-following-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#11
Pravesh Kumar Bundhun, Chakshu Gupta, Guang Ma Xu
BACKGROUND: We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis. METHODS: Electronic databases (Cochrane library, EMBASE and Medline/PubMed) were searched for English publications comparing in-hospital and long-term MACEs and mortality following PCI in patients with a past medical history of COPD...
July 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28715518/early-accurate-diagnosis-and-early-intervention-in-cerebral-palsy-advances-in-diagnosis-and-treatment
#12
Iona Novak, Cathy Morgan, Lars Adde, James Blackman, Roslyn N Boyd, Janice Brunstrom-Hernandez, Giovanni Cioni, Diane Damiano, Johanna Darrah, Ann-Christin Eliasson, Linda S de Vries, Christa Einspieler, Michael Fahey, Darcy Fehlings, Donna M Ferriero, Linda Fetters, Simona Fiori, Hans Forssberg, Andrew M Gordon, Susan Greaves, Andrea Guzzetta, Mijna Hadders-Algra, Regina Harbourne, Angelina Kakooza-Mwesige, Petra Karlsson, Lena Krumlinde-Sundholm, Beatrice Latal, Alison Loughran-Fowlds, Nathalie Maitre, Sarah McIntyre, Garey Noritz, Lindsay Pennington, Domenico M Romeo, Roberta Shepherd, Alicia J Spittle, Marelle Thornton, Jane Valentine, Karen Walker, Robert White, Nadia Badawi
Importance: Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age. Objectives: To systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function...
July 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28714821/leaving-the-lecture-behind-putting-pubmed-instruction-into-the-hands-of-the-students
#13
Rose L Turner, Andrea M Ketchum, Melissa A Ratajeski, Charles B Wessel
This column describes the development of a one-shot PubMed instruction class for medical students at a health sciences library. Background information on the objective is presented and discussed in the context of educational practice literature. The new course design centers on a guided group method of instruction in order to integrate more active learning. Surveyed students reported that the method was an effective way to learn how to search PubMed and that they preferred it to a traditional lecture. Pros and cons of the method are offered for other health sciences libraries interested in presenting PubMed instruction in a similar manner...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714815/an-introduction-to-the-blockchain-and-its-implications-for-libraries-and-medicine
#14
Matthew B Hoy
The blockchain is a relatively new technology used to verify and store transaction records for online cryptocurrencies like Bitcoin. The system is redundant and distributed, making it difficult for transactions to be rescinded, duplicated, or faked. Beyond online currencies, the blockchain has potential uses in health care, education, and many other fields. This column will briefly describe what the blockchain is and how it is being used, potential future uses that may be of interest to librarians and medical practitioners, and some of the problems with the system...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714814/using-time-driven-activity-based-costing-to-implement-change
#15
Ellen N Sayed, Sa'ad Laws, Basim Uthman
Academic medical libraries have responded to changes in technology, evolving professional roles, reduced budgets, and declining traditional services. Libraries that have taken a proactive role to change have seen their librarians emerge as collaborators and partners with faculty and researchers, while para-professional staff is increasingly overseeing traditional services. This article addresses shifting staff and schedules at a single-service-point information desk by using time-driven activity-based costing to determine the utilization of resources available to provide traditional library services...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714812/interprofessional-education-and-medical-libraries-partnering-for-success-edited-by-mary-e-edwards
#16
Marissa F Gauthier
No abstract text is available yet for this article.
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714362/impact-of-tumor-architecture-on-disease-recurrence-and-cancer-specific-mortality-of-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#17
Bo Fan, Bin Hu, Qingmin Yuan, Shuang Wen, Tianqing Liu, Shanshan Bai, Xiaofeng Qi, Xin Wang, Deyong Yang, Xiuzhen Sun, Xishuang Song
Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. Recent publications have assessed the prognostic significance of tumor architecture in UTUC, but there is still controversy regarding the significance and importance of tumor architecture on disease recurrence. We retrospectively reviewed the medical records of 101 patients with clinical UTUC who had undergone surgery. Univariate and multivariate analyses were conducted to identify factors associated with disease recurrence and cancer-specific mortality...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28712986/the-effectiveness-of-distraction-as-procedural-pain-management-technique-in-paediatric-oncology-patients-a-meta-analysis-and-systematic-review
#18
REVIEW
Ibitoye M Bukola, Dawson Paula
CONTEXT: Diagnostic tests and treatment regimens for paediatric cancers involve invasive and painful procedures. Effective management of such pain has been shown to be sub-optimal in many parts of the world, often due to the cost and limited availability of appropriate medications. Current evidence suggests that distraction (a relatively low-cost technique) is a promising intervention for procedural pain management. There is, however, limited evidence demonstrating its effectiveness in paediatric oncology patients...
July 13, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28704470/mammary-candidiasis-a-medical-condition-without-scientific-evidence
#19
Esther Jiménez, Rebeca Arroyo, Nivia Cárdenas, María Marín, Pilar Serrano, Leonides Fernández, Juan M Rodríguez
Many physicians, midwives and lactation consultants still believe that yeasts (particularly Candida spp.) play an important role as an agent of nipple and breast pain despite the absolute absence of scientific proofs to establish such association. In this context, the objective of this study was to investigate the microorganisms involved in sore nipples and/or painful "shooting" breastfeeding by using a variety of microscopy techniques, as well as culture-dependent and-independent identification methods. Initially, 60 women (30 diagnosed as suffering "mammary candidiasis" and 30 with no painful breastfeeding) were recruited to elucidate the role of their pumps on the milk microbial profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28702386/disorders-of-the-long-head-of-the-biceps-tenotomy-versus-tenodesis
#20
Fabiano Rebouças Ribeiro, André Petry Sandoval Ursolino, Vinicius Ferreira Lima Ramos, Fernando Hovaguim Takesian, Antonio Carlos Tenor Júnior, Miguel Pereira da Costa
Disorders of the long head of biceps tendon are common in clinical practice. Their causes could be degenerative, inflammatory, instability (subluxation or luxation) or traumatic. They are generally associated to other diseases of the shoulder, mainly rotator cuff injuries. Currently, there is controversy in the literature regarding the indications for surgical treatment and the choice of the best technique for each case, due to the possibility of esthetic deformity, loss of muscle strength, and residual pain...
May 2017: Revista Brasileira de Ortopedia
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