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https://www.readbyqxmd.com/read/29149766/numerosity-estimation-benefits-from-transsaccadic-information-integration
#1
Carolin Hübner, Alexander C Schütz
Humans achieve a stable and homogeneous representation of their visual environment, although visual processing varies across the visual field. Here we investigated the circumstances under which peripheral and foveal information is integrated for numerosity estimation across saccades. We asked our participants to judge the number of black and white dots on a screen. Information was presented either in the periphery before a saccade, in the fovea after a saccade, or in both areas consecutively to measure transsaccadic integration...
November 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29149765/sorption-desorption-of-antimony-species-onto-calcined-hydrotalcite-surface-structure-and-control-of-competitive-anions
#2
Leonel Vinicius Constantino, Juliana Nunes Quirino, Taufik Abrão, Paulo Sérgio Parreira, Alexandre Urbano, Maria Josefa Santos
Calcined hydrotalcite can be applied to remove anionic contaminants from aqueous systems such as antimony species due to its great anion exchange capacity and high surface area. Hence, this study evaluated antimonite and antimonate sorption-desorption processes onto calcined hydrotalcite in the presence of nitrate, sulfate and phosphate. Sorption and desorption experiments of antimonite and antimonate were carried out in batch equilibrium and the post-sorption solids were analyzed by X-ray fluorescence (EDXRF)...
November 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29149758/oligotrophy-as-a-major-driver-of-mercury-bioaccumulation-in-medium-to-high-trophic-level-consumers-a-marine-ecosystem-comparative-study
#3
Tiphaine Chouvelon, Pierre Cresson, Marc Bouchoucha, Christophe Brach-Papa, Paco Bustamante, Sylvette Crochet, Françoise Marco-Miralles, Bastien Thomas, Joël Knoery
Mercury (Hg) is a global contaminant of environmental concern. Numerous factors influencing its bioaccumulation in marine organisms have already been described at both individual and species levels (e.g., size or age, habitat, trophic level). However, few studies have compared the trophic characteristics of ecosystems to explain underlying mechanisms of differences in Hg bioaccumulation and biomagnification among food webs and systems. The present study aimed at investigating the potential primary role of the trophic status of systems on Hg bioaccumulation and biomagnification in temperate marine food webs, as shown by their medium-to high-trophic level consumers...
November 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29149735/carbamazepine-lamotrigine-levetiracetam-and-valproic-acid-in-dried-blood-spots-with-liquid-chromatography-tandem-mass-spectrometry-method-development-and-validation
#4
Camilla Linder, Anna Hansson, Sara Sadek, Lars L Gustafsson, Anton Pohanka
Monitoring of antiepileptic drugs in children with epilepsy require multiple visits at a clinic for blood collection. Dried blood spot sampling is an alternative way of collection, performed at home by self-collection and can save time and costs for patients and family members. The aim was to develop and validate an LC-MS/MS dried blood spot method for carbamazepine, lamotrigine, levetiracetam and valproic acid with the requirements of using standard equipment and material in a routine laboratory setting. Whatman-903 filter paper was utilized, and discs were punched into a 96 well plate with an automated puncher and barcode reading...
November 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29149718/coronary-risk-assessment-at-x-ray-dose-equivalent-ungated-chest-ct-results-of-a-multi-reader-study
#5
Michael Messerli, Lukas Hechelhammer, Sebastian Leschka, René Warschkow, Simon Wildermuth, Ralf W Bauer
OBJECTIVES: To determine the value of ultra-low dose chest CT with tin filtration for ordinal coronary artery calcium (CAC) risk scoring. METHODS: 50 patients were prospectively included and underwent clinical standard dose chest CT (1.8±0.7mSv) and ultra-low dose CT (0.13±0.01mSv). Four radiologists estimated presence and extent of CAC. RESULTS: Weighted kappa values for CAC were 0.76-0.97 in standard dose and 0.75-0.95 in ultra-low dose CT (p<0...
October 25, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29149714/influence-of-fe-ii-on-the-se-iv-sorption-under-oxic-anoxic-conditions-using-bentonite
#6
Jiangang He, Yanlin Shi, Xiaoyu Yang, Wanqiang Zhou, Yao Li, Chunli Liu
(79)Se, one of the key radionuclides for nuclear waste disposal, threatens the quality of the environment, as well as human health. Therefore, it needs to be permanently isolated from the biosphere. The aim of the study was to investigate the effects of Fe(II)/Fe(III) on the removal of (79)Se using bentonite in the pH range of 2.0-10.0 under oxic/anoxic conditions. Under oxic conditions, Se(IV) prefers to form inner-sphere complexes with Fe(III)-oxyhydroxide, derived from the oxidization of Fe(II) using oxygen...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29149672/the-application-of-bacteriophages-as-novel-indicators-of-viral-pathogens-in-wastewater-treatment-systems
#7
Edgard Dias, James Ebdon, Huw Taylor
Many wastewater treatment technologies have been shown to remove bacterial pathogens more effectively than viral pathogens and, in aquatic environments, levels of traditional faecal indicator bacteria (FIB) do not appear to correlate consistently with levels of human viral pathogens. There is, therefore, a need for novel viral indicators of faecal pollution and surrogates of viral pathogens, especially given the increasing importance of indirect and direct wastewater reuse. Potential candidates include bacteriophages (phages) and the study described here sought to elucidate the relationship between three groups of phages (somatic coliphages (SOMPH), F-RNA coliphages (F-RNAPH) and human-specific phages infecting B...
November 9, 2017: Water Research
https://www.readbyqxmd.com/read/29149666/relationship-between-radiographic-patella-alta-pathology-and-walking-dysfunction-in-children-with-bilateral-spastic-cerebral-palsy
#8
Matthias Hösl, Harald Böhm, Michaela Seltmann, Chakravarthy Ugandhar Dussa, Leonhard Döderlein
BACKGROUND: Patella-alta is very common in patients with Cerebral Palsy (CP). While several diagnostic x-ray indices have been developed for patella-alta in general, the specific relationship with walking dysfunction in CP is only partly understood. METHODS: 33 participants with bilateral spastic CP between 4 and 20 years (GMFCS I-II without previous surgery) that underwent 3D gait analysis as well as a radiographic exam within 0.8 (SD 1.2) months were retrospectively included...
November 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29149611/core-clinical-data-elements-for-cancer-genomic-repositories-a-multi-stakeholder-consensus
#9
Robert B Conley, Dane Dickson, Jean Claude Zenklusen, Jennifer Al Naber, Donna A Messner, Ajlan Atasoy, Lena Chaihorsky, Deborah Collyar, Carolyn Compton, Martin Ferguson, Sean Khozin, Roger D Klein, Sri Kotte, Razelle Kurzrock, C Jimmy Lin, Frank Liu, Ingrid Marino, Robert McDonough, Amy McNeal, Vincent Miller, Richard L Schilsky, Lisa I Wang
The Center for Medical Technology Policy and the Molecular Evidence Development Consortium gathered a diverse group of more than 50 stakeholders to develop consensus on a core set of data elements and values essential to understanding the clinical utility of molecularly targeted therapies in oncology.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149587/%C3%A2-and-the-wisdom-to-know-the-difference-scholarly-success-from-a-wisdom-perspective
#10
Judith Glück
What makes a researcher wise? At least for the field of psychology, I argue that the two main characteristics of scholarly wisdom are a desire to understand, rather than to be right, and an orientation toward ethical values. These characteristics do not necessarily produce the highest levels of academic success. Because wisdom is partly context dependent, the actual wisdom of our scientific output could be increased by making some changes to our publication and evaluation culture-changes that might benefit our field and even the world around us...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149579/doing-for-the-greater-good-what-price-in-academe
#11
Suniya S Luthar
In discussing how merit is commonly judged in academia, my focus in this article is not on dimensions that are currently considered but on those that warrant more attention. Grounded in suggestions offered by Sternberg, I argue here for increased recognition of faculty's commitment to intrinsic values-focused on community and relationships-and not just extrinsic ones that connote personal fame or status. I first summarize evidence of disillusionment among today's promising young scholars and then provide exemplars of role models who have, in fact, maintained high standards in both intrinsic and extrinsic domains...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149578/afterword-in-the-matter-of-judging-scientific-merit
#12
Robert J Sternberg
In this afterword, I suggest expanding upon some of the criteria for judging scientific merit that have been discussed in the two symposia on "judging scholarly merit in psychological science." I discuss in particular the value of creativity, analysis, common sense, and wisdom and ethics in scientific contributions and discourse. In the course of this discussion, I consider where the field of judging scientific merit has been, where it is now, and where it may go.
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149575/researchers-of-color-fame-and-impact
#13
Michael A Zárate, Gordon Nagayama Hall, Victoria C Plaut
Fame and eminence, as traditionally measured, limit the definition of impact to the publication world. We add two types of impact to the traditional measures of fame and eminence. Many of the traditional measures of fame or eminence are based on social-network connections, whereby individuals appoint other people to positions of eminence. Editorial boards are one specific example. Eminence is also limited to number of publications, for example, with little regard for the impact of those publications at the societal level...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149564/binding-thermodynamics-and-kinetics-calculations-using-chemical-host-and-guest-a-comprehensive-picture-of-molecular-recognition
#14
Zhiye Tang, Chia-En A Chang
Understanding the fine balance between changes of entropy and enthalpy and the competition between a guest and water molecules in molecular binding is crucial in fundamental studies and practical applications. Experiments provide measurements. However, illustrating the binding/unbinding processes gives a complete picture of molecular recognition not directly available from experiments, and computational methods bridge the gaps. Here, we investigated guest association/dissociation with β-cyclodextrin (β-CD) by using microsecond-timescale molecular dynamics (MD) simulations, post-analysis and numerical calculations...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149556/evaluating-force-field-london-dispersion-coefficients-using-the-exchange-hole-dipole-moment-model
#15
Mohamad Mohebifar, Erin R Johnson, Christopher N Rowley
London dispersion interactions play an integral role in materials science and biophysics. Force fields for atomistic molecular simulations typically represent dispersion interactions by the 12-6 Lennard-Jones potential, using empirically-determined parameters. These parameters are generally underdetermined and there is no straightforward way to test if they are physically realistic. Alternatively, the exchange-hole dipole moment (XDM) model from density-functional theory predicts atomic and molecular London dispersion coefficients from first principles, providing an innovative strategy to validate the dispersion terms of molecular-mechanical force fields...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149554/boron-dissolved-and-dust-atmospheric-inputs-to-a-forest-ecosystem-northeastern-france
#16
Philippe Roux, Marie Pierre Turpault, Gil Kirchen, Paul-Olivier Redon, Damien Lemarchand
Boron concentrations and isotopic compositions of atmospheric dust and dissolved depositions were monitored over a two-years period (2012-2013) in the forest ecosystem of Montiers (Northeastern France). This time series allows the determination of the boron atmospheric inputs to this forest ecosystem and contributes to refine our understanding of the sources and processes that control the boron atmospheric cycle. Mean annual dust and dissolved boron atmospheric depositions are comparable in size (13 g.ha-1...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149549/workflow-for-target-oriented-parametrization-of-an-enhanced-mechanistic-cell-culture-model
#17
Sophia Ulonska, Paul Kroll, Jens Fricke, Christoph Clemens, Raphael Voges, Markus Michael Müller, Christoph Herwig
The goal of this study was to develop a macroscopic mechanistic model describing growth and production within fed-batch cultivations of CHO cells. The model should be used for process characterization as well as for process monitoring including real-time parameter adaptations. The model proved to be able to describe a data-set of 40 processes differing in clones, scales and process conditions with a normalized root mean square error of approximately 10%. However, due to limited parameter identifiability and limited knowledge about physiologically meaningful parameter values, a broad range of parameters could describe the data with similar quality...
November 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29149547/engineering-escherichia-coli-co-cultures-for-production-of-curcuminoids-from-glucose
#18
Zhen Fang, J Andrew Jones, Jingwen Zhou, Mattheos A G Koffas
Curcuminoids have attracted increasing attention because of the antioxidant, anticancer, and antitumor activities while their production is limited because of its main source, turmeric plant, demonstrates extensive seasonal variation. In this study, we constructed Escherichia coli co-culture system for the rapid production of curcuminoids from glucose. Firstly, the overexpression of curcuminoid synthase and four different strategies related to increasing the intracellular malonyl-CoA pool were conducted in engineered E...
November 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29149541/diagnostic-accuracy-of-serum-mir-122-and-mir-199a-in-women-with-endometriosis
#19
Ahmed M Maged, Wesam S Deeb, Azza El Amir, Sherif S Zaki, Heba El Sawah, Maged Al Mohamady, Ahmed A Metwally, Maha A Katta
OBJECTIVE: To evaluate the value of serum microRNA-122 (miR-122) and miR-199a as reliable noninvasive biomarkers in the diagnosis of endometriosis. METHODS: During 2015-2016, at a teaching hospital in Egypt, a prospective cohort study was conducted on 45 women with pelvic endometriosis and 35 women who underwent laparoscopy for pelvic pain but were not diagnosed with endometriosis. Blood and peritoneal fluid (PF) samples were collected; interleukin-6 (IL-6) was detected by enzyme-linked immunosorbent assay and miR-122 and miR-199a expression was measured by quantitative real-time polymerase chain reaction...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29149534/novel-n-propylphthalimide-and-4-vinylbenzyl-substituted-benzimidazole-salts-synthesis-characterization-and-determination-of-their-metal-chelating-effects-and-inhibition-profiles-against-acetylcholinesterase-and-carbonic-anhydrase-enzymes
#20
Yakup Sarı, Aydın Aktaş, Parham Taslimi, Yetkin Gök, İlhami Gulçin
The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using (1) H NMR, (13) C NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with Ki values in the range of 351...
November 17, 2017: Journal of Biochemical and Molecular Toxicology
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