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https://www.readbyqxmd.com/read/28945059/tissue-dielectric-constant-and-circumference-measurement-in-the-follow-up-of-treatment-related-changes-in-lower-limb-lymphedema
#1
Alper Tugral, Tuomas Viren, Yesim Bakar
BACKGROUND: Lymphedema of lower limbs is a chronic condition that requires life-long management. Therapeutic effect of Complex Decongestive Physiotherapy (CDP) is most often followed by circumference measurements (CM). However, the CM measurements are not specific to interstitial tissue fluid and have problems in sensitivity and objectivity. The aim of present study was to evaluate the therapeutic effect of CDP with a new tissue water specific measurement technique, in patients with lower limb lymphedema (LLL)...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28945041/-dynamic-serum-metabolomics-study-of-liver-injury-in-rats-caused-by-polygonum-multifulorum
#2
Zhi-Jie Ma, Qi Li, Kui-Jun Zhao, Jia-Bo Wang, Xiao-He Xiao
Liquid chromatography-mass spectrometry method was used for determination of metabolic fingerprint spectrum in rat serum, and the method of multivariate statistical analysis was used to compare the metabolism spectrum difference and screen significantly related biomarkers. The dynamic change trend was investigated at the same time. The dynamic metabonomics changes of liver injury in rats caused by Polygonum multifulorum(PM) were investigated; significantly related biomarkers were found and their dynamic change trend was investigated to provide basis for internal mechanism and early clinical diagnosis...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945022/-progress-of-gene-editing-technologies-and-prospect-in-traditional-chinese-medicine
#3
REVIEW
Yan-Yan Ma, Jing-Zhe Li, Er-Ning Gao, Dan Qian, Ju-Ying Zhong, Chang-Zhen Liu
Gene editing is a kind of technologies that makes precise modification to the genome. It can be used to knock out/in and replace the specific DNA fragment, and make accurate gene editing on the genome level. The essence of the technique is the DNA sequence change with use of non homologous end link repair and homologous recombination repair, combined with specific DNA target recognition and endonuclease.This technology has wide range of development prospects and high application value in terms of scientific research, agriculture, medical treatment and other fields...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945016/cultural-hair-practices-physical-activity-and-obesity-among-urban-african-american-girls
#4
Felesia Bowen, Patricia O'Brien-Richardson
BACKGROUND AND PURPOSE: Hair holds cultural meaning and value for women of African descent. The values placed on hair type and hair style date back to preslavery days. There is a small body of literature that addresses the relationship between cultural hair practices and physical inactivity among black women. Understanding this is important because inactivity during childhood and adolescent years contributes to increased weight-related morbidity and mortality during adult years. The purpose of this study was to determine the relationship between cultural hair practices, physical activity, and obesity among urban African-American adolescent girls...
September 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28944993/evaluation-of-prolonged-exposure-to-varenicline-in-adult-rats-hematological-biochemical-and-anatomopathological-studies
#5
Julia Zaccarelli-Magalhães, Natalia Moreira, Thaisa Meira Sandini, Gabriel Ramos de Abreu, Angélica Maria Sánchez-Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice de Souza Spinosa
Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for α4β2 and α3β4 nicotinic cholinergic receptors and as a total agonist for α7 receptor. While there are studies regarding varenicline's non-smoking-related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long-term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through hematological, biochemical and anatomopathological parameters of prolonged exposure (30 days) to varenicline in rats...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944986/development-and-in-vitro-in-vivo-evaluation-of-a-novel-benznidazole-liquid-dosage-form-using-a-quality-by-design-approach
#6
Higo Fernando Santos Souza, Daniel Real, Darío Leonardi, Sandra Carla Rocha, Victoria Alonso, Esteban Serra, Ariel Mariano Silber, Claudio Javier Salomon
OBJECTIVES: To develop an alcohol-free solution suitable for children of benznidazole, the drug of choice for treatment of Chagas disease. METHODS: In a quality-by-design approach a systematic optimization procedure was carried out in order to estimate the values of the factors leading to the maximum drug concentration. The formulations were analyzed in terms of chemical and physical stability and drug content. The final preparation was subjected to an in-vivo palatability assay...
September 25, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28944980/failure-mode-and-effects-analysis-a-community-practice-perspective
#7
Bradley W Schuller, Angi Burns, Elizabeth A Ceilley, Alan King, Joan LeTourneau, Alexander Markovic, Lynda Sterkel, Brigid Taplin, Jennifer Wanner, Jeffrey M Albert
PURPOSE: To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS: The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high profile radiation therapy accidents. A multidisciplinary team was assembled with representation from each of the major department disciplines. Stereotactic radiosurgery (SRS) was identified as the most appropriate treatment technique for the first FMEA evaluation, as it is largely self-contained and has the potential to produce high impact failure modes...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944963/standardized-ileal-digestibility-and-digestible-indispensable-amino-acid-score-of-porcine-and-bovine-hydrolyzates-in-pigs
#8
Yugal Raj Bindari, Helle Nygaard Laerke, Jan Vaerum Nørgaard
BACKGROUND: Using protein hydrolyzates in food and feed ingredients is a growing area of interest. The present study was conducted to determine the standardized ileal digestibility (SID) and to evaluate protein quality of porcine and bovine hydrolyzates. The SID values were determied in pigs, and these values were used to calculate DIAAS values. RESULTS: The SID of crude protein of hydrolyzates of porcine plasma, bovine muscle, bovine collagen, porcine heart, and porcine muscle was 0...
September 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28944960/application-of-high-pressure-homogenization-on-gums-a-review
#9
REVIEW
Ricardo Henrique Belmiro, Alline Artigiani Lima Tribst, Marcelo Cristianini
High pressure homogenization (HPH) is an emerging process in which a fluid product is pumped by pressure intensifiers forcing it to flows through a narrow gap, usually measured in the order of micrometers. Gums are polysaccharides from vegetal, animal or microbial origin, widely employed in food and chemical industries as thickeners, stabilizers, gelling agents and emulsifiers. Choosing a specific gum will depend on its application and purpose, as each form of gum has particular values for viscosity, intrinsic viscosity, stability, emulsifying and gelling properties, being these parameters determined by its structure...
September 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28944943/effect-of-systemic-application-of-bone-marrow-derived-mesenchymal-stem-cells-on-healing-of-peripheral-nerve-injury-in-an-experimental-sciatic-nerve-injury-model
#10
Zahir Kizilay, Serdar Aktas, Nesibe Kahraman Cetin, Didem Bakay Ilhan, Gulfem Ersoy, Haydar Ali Erken
AIM: To investigate the effects of systemic application of bone marrow-derived mesenchymal stem cells in a compression model of peripheral nerve injury. MATERIAL AND METHODS: 24 male Wistar albino rats were randomly divided into 3 equal groups (n=8):Control (C),injury (I),and stem cell and injury (SI).The sciatic nerve of rats in the I and SI groups was subjected to clip compression for 5 minutes.Moreover,approximately 5x105 bone marrow-derived mesenchymal stem cells were given via tail vein of the rats in the SI group immediately after clip compression...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944907/placenta%C3%A2-derived-mesenchymal-stem-cells-improve-airway-hyperresponsiveness-and-inflammation-in-asthmatic-rats-by-modulating-the-th17-treg-balance
#11
Yingying Li, Hongbo Li, Yinyin Cao, Fuling Wu, Wenbin Ma, Yuesi Wang, Shuzhen Sun
Mesenchymal stem cells (MSCs) possess reparative and immunoregulatory properties, representing a hope for stem cell‑based treatments. However, the mechanisms by which transplanted MSCs affect T helper (Th)17/regulatory T cell (Treg) balance in asthma patients remain unclear. The aim of the present study was to assess the therapeutic effects of human placenta MSCs (hPMSCs) in asthma, and explore the underlying mechanisms; in addition, the impact of hPMSCs transplantation on Th17/Treg balance in lymph and serum samples from asthmatic animals was evaluated...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944897/high-expression-of-endoglin-in-primary-breast-cancer-may-predict-response-to-neoadjuvant-chemotherapy
#12
Kun-Ming Rau, Yu-Li Su, Shan-Hsuan Li, Meng-Che Hsieh, Shis-Chung Wu, Fong-Fu Chou, Tai-Jan Chiu, Yen-Hao Chen, Chien-Ting Liu
Neoadjuvant chemotherapy (NAC) is a widely‑used treatment for breast cancer, as it may render unresecta-ble breast tumors to become resectable. In addition, NAC provides the unique opportunity to assess response to treatments within months rather than years of follow‑up. However, predictive markers of tumor response to NAC are lacking. Therefore, the present study aimed to investigate the expression of endoglin, a marker of angiogenesis, and its association with pathologic responses to NAC. Samples from 34 breast cancer patients were obtained prior to and following NAC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944843/microarray-and-bioinformatics-analyses-of-gene-expression-profiles-in-balb-c-murine-macrophage-polarization
#13
Li Jiang, Xueqin Li, Yingying Zhang, Mengying Zhang, Zongsheng Tang, Kun Lv
Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M1 and M2 polarized phenotypes. The aim of the present study was to screen for differentially-expressed genes (DEGs) that were associated with BALB/c murine macrophage polarization. The transcription profiles of three M1 and three M2 samples were obtained using microarray analysis. Based on the threshold of fold‑change >2.0 and P‑value <0.05, a total of 1,253 DEGs were identified, of which 696 were upregulated and 557 downregulated in M1 macrophages compared with M2 macrophages...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944815/chemical-mediated-elasto-capillarity-of-elastic-sheets
#14
Jianlin Liu, Yulong Gong, Gaofeng Cao
Capillary forces can cause outstanding deformation of slender structures, and this behavior holds great potential in a plethora of areas. In this study, we propose a facile strategy to mediate the deformation of elastic structures via chemicals, which is named chemo-elasto-capillarity. The experiment shows that the added surfactant can significantly change the interfacial energy of the system, and then modulate the configuration of the adhered structures. The wetted length and deflection of each sheet can be predicted using the large and infinitesimal deformation theory of beams, and these theoretical values are in excellent agreement with the experimental results...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944753/asymmetry-of-movements-in-cftr-s-two-atp-sites-during-pore-opening-serves-their-distinct-functions
#15
Ben Sorum, Beáta Töröcsik, László Csanády
CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, is opened by ATP binding to two cytosolic nucleotide binding domains (NBDs), but pore-domain mutations may also impair gating. ATP-bound NBDs dimerize occluding two nucleotides at interfacial binding sites; one site hydrolyzes ATP, the other is inactive. The pore opens upon tightening, and closes upon disengagement, of the catalytic site following ATP hydrolysis. Extent, timing, and role of non-catalytic-site movements are unknown. Here we exploit equilibrium gating of a hydrolysis-deficient mutant and apply F value analysis to compare timing of opening-associated movements at multiple locations, from the cytoplasmic ATP sites to the extracellular surface...
September 25, 2017: ELife
https://www.readbyqxmd.com/read/28944733/performance-based-risk-sharing-arrangements-for-pharmaceutical-products-in-the-united-states-a-systematic-review
#16
Justin S Yu, Lauren Chin, Jennifer Oh, Jorge Farias
BACKGROUND: Value for money is a growing necessity in today's U.S. health care system in which drug spending is expected to increase by an average rate of 6.7% yearly through 2025. In response to uncertainty about real-world clinical and economic outcomes for many drugs, health insurers and pharmacy benefit managers (PBMs) have implemented various contracts and arrangements with drug manufacturers that can collectively be described as performance-based risk-sharing arrangements (PBRSAs)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#17
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944729/using-performance-based-risk-sharing-arrangements-to-address-uncertainty-in-indication-based-pricing
#18
Kai Yeung, Meng Li, Josh J Carlson
BACKGROUND: The rise in pharmaceutical expenditures in recent years has increased health care payer interest in ensuring good value for the money. Indication-based pricing (IBP) sets separate, indication-specific prices paid to the manufacturer according to the expected efficacy of a drug in each of its indications. IBP allows payers to consistently pay for value across indications. While promising, a limitation of IBP as originally conceived is that efficacy estimates are typically based on clinical trial data, which may differ from real-world effectiveness...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944728/performance-based-risk-sharing-arrangements-u-s-payer-experience
#19
Joseph A Goble, Brian Ung, Sascha van Boemmel-Wegmann, Robert P Navarro, Andrew Parece
BACKGROUND: As a result of global concern about rising drug costs, many U.S. payers and European agencies such as the National Health Service have partnered with pharmaceutical companies in performance-based risk-sharing arrangements (PBRSAs) by which manufacturers share financial risk with health care purchasing entities and authorities. However, PBRSAs present many administrative and legal challenges that have minimized successful contract experiences in the United States. OBJECTIVE: To (a) identify drug and disease characteristics and contract components that contribute to successful PBRSA experiences and the primary barriers to PBRSA execution and (b) explore solutions to facilitate contract negotiation and execution...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944727/changing-the-way-we-pay-for-health-care-is-value-the-new-plastic
#20
Robert P Navarro
Navarro is a clinical professor in the College of Pharmacy at the University of Florida, Gainesville, and is an assistant editor with the Journal of Managed Care and Specialty Pharmacy. Navarro reports consulting fees from Analysis Group, Amgen, Novartis, and Allergan.
October 2017: Journal of Managed Care & Specialty Pharmacy
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