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Relational aggression

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https://www.readbyqxmd.com/read/29791913/lymphadenectomy-and-adjuvant-therapy-improve-survival-with-uterine-carcinosarcoma-a-large-retrospective-cohort-study
#1
Marco A C Versluis, Cindy Pielsticker, Maaike A van der Aa, Marco de Bruyn, Harry Hollema, Hans W Nijman
OBJECTIVE: Uterine carcinosarcoma is a rare, aggressive subtype of endometrial cancer. Treatment consists of hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy (LND). The survival benefit of LND in relation to adjuvant radio- and/or chemotherapy is unclear. We evaluated the impact of LND on survival in relation to adjuvant therapy in uterine carcinosarcoma. METHODS: Retrospective data on 1,140 cases were combined from the Netherlands Cancer Registry (NCR) and the nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA)...
May 23, 2018: Oncology
https://www.readbyqxmd.com/read/29791630/violence-against-the-brazilian-elderlies-an-analysis-of-hospitalizations
#2
Vivian Carla de Castro, Leidyani Karina Rissardo, Lígia Carreira
OBJECTIVE: to identify the prevalence of physical aggression and neglect and abandonment in the hospitalizations of Brazilian elderly people for violence and assault from 2008 to 2013 and the association of these causes with socio-demographic variables related to hospitalization. METHOD: quantitative, descriptive, cross-sectional study with elderlies hospitalized for assault. INCLUSION CRITERIA: to be 60 years old or over, to have been hospitalized in the Unified Health System (SUS) for assault or neglect and abandonment, between 2008 and 2013...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29790920/elucidating-the-role-of-the-maternal-embryonic-leucine-zipper-kinase-melk-in-adrenocortical-carcinoma
#3
Katja Kiseljak-Vassiliades, Yu Zhang, Adwitiya Kar, Raud Razzaghi, Mei Xu, Katherine Gowan, Christopher D Raeburn, Maria Albuja-Cruz, Kenneth L Jones, Hilary Somerset, Lauren Fishbein, Stephen Leong, Margaret E Wierman
Adrenocortical carcinoma (ACC) is an aggressive cancer with a five-year survival less than 35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified Maternal Embryonic Leucine Zipper Kinase (MELK) as 4.1-fold overexpressed in ACC compared to normal adrenal samples. High MELK expression in human tumors correlated with shorter survival and with increased expression of genes involved in cell division and growth. We investigated the functional effects of MELK inhibition using newly developed ACC cell lines with variable MELK expression, CU-ACC1 and CU-ACC2, compared with H295R cells...
May 21, 2018: Endocrinology
https://www.readbyqxmd.com/read/29790179/merkel-cell-carcinoma-clinical-outcome-and-prognostic-factors-in-351-patients
#4
Linde M van Veenendaal, Alexander C J van Akkooi, Cees Verhoef, Dirk Jan Grünhagen, W Martin C Klop, Gerlof D Valk, Margot E T Tesselaar
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin. AIM: To describe clinical outcome and prognostic factors of MCC patients in two expert-centers. METHOD: Patients with histologically confirmed MCC in 1990-2014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected. RESULTS: A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28-94)...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29789326/hepatocellular-carcinoma-outcome-is-predicted-by-expression-of-neuronal-calcium-sensor-1
#5
Daniel Schuette, Lauren M Moore, Marie E Robert, Tamar H Taddei, Barbara E Ehrlich
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. There is an urgent demand for prognostic biomarkers that facilitate early tumor detection, as the incidence of HCC has tripled in the USA in the last three decades. Biomarkers to identify populations at risk would have significant impact on survival. We recently found that expression of Neuronal Calcium Sensor 1 (NCS1), a Ca2+-dependent signaling molecule, predicted disease outcome in breast cancer, but its predictive value in other cancer types is unknown...
May 22, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29788762/distinct-patterns-of-internet-and-smartphone-related-problems-among-adolescents-by-gender-latent-class-analysis
#6
Seung-Yup Lee, Donghwan Lee, Cho Rong Nam, Da Yea Kim, Sera Park, Jun-Gun Kwon, Yong-Sil Kweon, Youngjo Lee, Dai Jin Kim, Jung-Seok Choi
Background and objectives The ubiquitous Internet connections by smartphones weakened the traditional boundaries between computers and mobile phones. We sought to explore whether smartphone-related problems differ from those of computer use according to gender using latent class analysis (LCA). Methods After informed consents, 555 Korean middle-school students completed surveys on gaming, Internet use, and smartphone usage patterns. They also completed various psychosocial instruments. LCA was performed for the whole group and by gender...
May 23, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29788731/claudin-7-cldn7-is-overexpressed-in-gastric-cancer-and-promotes-gastric-cancer-cell-proliferation-invasion-and-maintains-mesenchymal-state
#7
Z Wu, J Shi, Y Song, J Zhao, J Sun, X Chen, P Gao, Z Wang
Gastric cancer (GC) ranks as the fourth most common cancer worldwide and is among the most aggressive types of cancer. Claudin-7 (CLDN7) has been found to be aberrantly expressed in some types of cancers. However, the expression and role of CLDN7 on gastric cancer (GC) remain largely unknown. In this study, we have performed the largest expression analysis study to date of CLDN7 in 113 pairs of human GC tissues and non-tumorous adjacent tissues. We found CLDN7 expression is significantly elevated in GC tissues, and the overexpression of CLDN7 is closely related to lymph node metastasis...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788728/clinical-characteristics-and-treatments-of-patients-with-alpha-fetoprotein-producing-gastric-carcinoma
#8
W Gong, Y Su, A Liu, J Liu, D Sun, T Jiang, J Xiang, C Chi, P Sun
Alpha-fetoprotein (AFP) is a well-known tumor marker of hepatic carcinoma and yolk sac tumor. Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare type of gastric cancer with high malignancy and poor prognosis, which make it different from other types of gastric cancer. This rare gastric cancer patient subgroup is likely frequently misdiagnosed which may be related to lack of knowledge of the disease. The purpose of this article is to summarize the mechanism of AFP positive gastric cancer, classification, biological behavior and treatment, in order to assist clinical practitioners to detect AFPGC earlier and treat it better...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788165/physical-activity-in-relation-to-risk-of-prostate-cancer-a-systematic-review-and-meta-analysis
#9
I N Benke, M F Leitzmann, G Behrens, D Schmid
Background: Prostate cancer (PCa) is one of the most common cancers among men, yet little is known about its modifiable risk and protective factors. This study aims to quantitatively summarize observational studies relating physical activity (PA) to PCa incidence and mortality. Materials and methods: Published articles pertaining to PA and PCa incidence and mortality were retrieved in July 2017 using the Medline and EMBASE databases. The literature review yielded 48 cohort studies and 24 case-control studies with a total of 151 748 PCa cases...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788079/long-term-ambient-temperature-and-externalizing-behaviors-in-adolescents
#10
Diana Younan, Lianfa Li, Catherine Tuvblad, Jun Wu, Fred Lurmann, Meredith Franklin, Kiros Berhane, Rob McConnell, Anna H Wu, Laura A Baker, Jiu-Chiuan Chen
The climate-violence relationship has been debated for decades, and yet most of the supportive evidence came from ecological or cross-sectional analyses with very limited long-term exposure data. We conducted an individual-level, longitudinal study to investigate the association between ambient temperature and externalizing behaviors of urban-dwelling adolescents. Participants (n = 1,287) of the Risk Factors for Antisocial Behavior Study were examined in 2000-2012 (aged 9-18 years) with repeated assessments of their externalizing behaviors (aggression; delinquency)...
May 21, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29786797/nmr-based-prostate-cancer-metabolomics
#11
Leslie R Euceda, Maria K Andersen, May-Britt Tessem, Siver A Moestue, Maria T Grinde, Tone F Bathen
Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish indolent cancer types from the aggressive ones. Reprogramming of metabolism is now a widely accepted hallmark of cancer development, where cancer cells must be able to convert nutrients to biomass while maintaining energy production. Metabolomics is the large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues, or organisms...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29785627/chemical-communication-and-reproduction-partitioning-in-social-wasps
#12
REVIEW
Francesca Romana Dani, Stefano Turillazzi
Social wasps encompass species displaying diverse social organization regarding colony cycle, nest foundation, caste differences (from none to significant dimorphism) and number of reproductive queens. Current phylogenetic data suggests that sociality occured independently in the subfamily Stenogastrinae and in the Polistinae+Vespinae clade. In most species, including those with the simplest social organization, colony reproduction is monopolised by a single or few females. Since their nest mates can also develop ovaries and lay eggs, dominant females must somehow inhibit them from reproducing...
May 22, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29785551/salivary-duct-carcinoma-evaluation-of-treatment-and-outcome-in-a-tertiary-referral-institute
#13
Ann-Jean C C Beck, Peter J F M Lohuis, Abrahim Al-Mamgani, Laura A Smit, Willem M C Klop
PURPOSE: The aggressive behavior of salivary duct carcinoma (SDC) necessitates an aggressive treatment strategy, including surgery and radiotherapy (RT). We evaluated practice patterns and treatment outcomes in patients with SDC treated in our Institute. METHODS: Patients with SDC of the parotid or submandibular gland treated with curative intention in our Institute from 1998 until 2016 were reviewed. Our diagnostic workup and treatment strategy were evaluated together with treatment outcomes...
May 21, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29785523/efficacy-and-safety-of-rituximab-in-relapsing-and-progressive-multiple-sclerosis-a-hospital-based-study
#14
Carmen Alcalá, F Gascón, F Pérez-Miralles, S Gil-Perotín, A Navarré, I Boscá, F Coret, B Casanova
INTRODUCTION: Rituximab is considered as a potential therapeutic option in relapsing-remitting (RRMS) and progressive forms (PMS) of multiple sclerosis (MS). OBJECTIVE: To investigate the effectiveness and safety of rituximab in MS. PATIENTS AND METHODS: Observational study of effectiveness (clinical and radiological) and safety of rituximab in RRMS and PMS. RESULTS: A total of 90 rituximab-treated patients were collected: 31 RRMS and 59 PMS All patients had an active disease despite standard treatment...
May 21, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29785316/a-pediatric-case-of-relapsing-remitting-multiple-sclerosis-onset-following-varicella-zoster-ophthalmicus-with-optic-neuritis
#15
Naoko Shiba, Yuji Inaba, Mitsuo Motobayashi, Makoto Nishioka, Yoichiro Kawasaki, Shunsuke Noda, Hiroki Matsuura, Norimoto Kobayashi, Takafumi Matsuoka, Akinori Nakamura, Yozo Nakazawa
Some epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS following the prolonged reactivation of VZV inside the first branch of the trigeminal nerve, exhibiting herpes zoster ophthalmicus with severe optic neuritis. Symptoms related to herpes zoster ophthalmicus and MS appeared consecutively in the 10-week period after the appearance of vesicles...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29785156/correlations-of-aldehyde-dehydrogenase-1-aldh1-expression-with-traditional-prognostic-parameters-and-different-molecular-subtypes-of-breast-carcinoma
#16
Piyabi Sarkar, Keya Basu, Pubali Sarkar, Uttara Chatterjee, Madhumita Mukhopadhyay, Manoj Kumar Choudhuri, Diptendra Kumar Srakar
Background and aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29784216/physical-and-mechanical-restraint-in-psychiatric-units-perceptions-and-experiences-of-nursing-staff
#17
Kelly Graziani Giacchero Vedana, Danielle Maria da Silva, Carla Aparecida Arena Ventura, Bianca Cristina Ciccone Giacon, Ana Carolina Guidorizzi Zanetti, Adriana Inocenti Miasso, Tatiana Longo Borges
BACKGROUND: Physical restraint in psychiatric units is a common practice but extremely controversial and poorly evaluated by methodologically appropriate investigations. The cultural issues and professionals' perceptions and attitudes are substantial contributors to the frequency of restraint that tend to be elevated. Aim In this qualitative study, we aimed to understand the experiences and perceptions of nursing staff regarding physical restraint in psychiatric units. METHOD: Through theoretical sampling, 29 nurses from two Brazilian psychiatric units participated in the study...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784062/multidrug-resistant-proteus-mirabilis-and-escherichia-coli-causing-fulminant-necrotising-fasciitis-a-case-report
#18
Eugene Vernyuy Yeika, Joyce Bei Foryoung, Derrick Tembi Efie, Eugene Adze Nkwetateba, Paul Nkemtendong Tolefac, Marcelin Ngowe Ngowe
BACKGROUND: Necrotizing fasciitis is a rare soft tissue infection characterized by rapid progressive necrosis with relative sparing of underlying muscles. This case is reported to highlight the emergence of multidrug resistant microbes in recent days which limits the use of empiric antibiotic therapy and necessitates early cultures and sensitivity enabling targeted antibiotic therapy. Factors that lead to antimicrobial resistance especially in sub-Saharan Africa have also been discussed...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29782838/non-invasive-assessment-of-glucocorticoid-and-androgen-metabolite-levels-in-cooperatively-breeding-damaraland-mole-rats-fukomys-damarensis
#19
Katarina Medger, Nigel C Bennett, Heike Lutermann, Andre Ganswindt
Dominant females of cooperative breeding species often use aggression to suppress reproduction of subordinate females, resulting in subordinates experiencing stress-related increases in glucocorticoid levels, which may cause reproductive down-regulation. This would suggest a general pattern with higher glucocorticoid levels in subordinate compared to dominant individuals; however, the opposite was found in a number of cooperatively breeding species. Furthermore, breeding females of the cooperatively breeding Damaraland mole-rats (Fukomys damarensis) exhibit very high androgen concentrations during the wet season, presumably to support their breeding monopoly...
May 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29782618/liver-targeted-therapies-for-hepatocellular-carcinoma-prior-to-transplant-contemporary-management-strategies
#20
Mustafa Nazzal, Sameer Gadani, Abdullah Said, Mandy Rice, Obi Okoye, Ahmad Taha, Krista L Lentine
Hepatocellular carcinoma (HCC) is an aggressive neoplastic disease that has been rapidly increasing in incidence. It usually occurs in the background of liver disease, and cirrhosis. Definitive therapy requires surgical resection. However, in majority of cases surgical resection is not tolerated, especially in the presence of portal hypertension and cirrhosis. Orthotopic liver transplant (OLT) in well selected candidates has been accepted as a viable option. Due to a relative scarcity of donors compared to the number of listed recipients, long waiting times are anticipated...
April 2018: Global surgery
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