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JOURNAL ARTICLE
Terese Knoppers, Cassandra E Haley, Sarah Bouhouita-Guermech, Julie Hagan, Jacqueline Bradbury-Jost, Samuel Alarie, Marie Cosquer, Ma'n H Zawati
BACKGROUND: Acute myeloid leukemia (AML), a rapidly progressing cancer of the blood and bone marrow, is the most common and fatal type of adult leukemia. Therapeutic web portals have great potential to facilitate AML research advances and improve health outcomes by increasing the availability of data, the speed and reach of new knowledge, and the communication between researchers and clinicians in the field. However, there is a need for stakeholder research regarding their optimal features, utility, and implementation...
2024: PloS One
#2
JOURNAL ARTICLE
Kata Eklics, Alexandra Csongor, Anikó Hambuch, Judit Diana Fekete
Medical education and communication training has been undergoing substantial changes recently in our globalized environment. Multidisciplinary simulation-based methods worldwide focus on improving effective clinical skills including history taking, physical examination, diagnostic skills, critical thinking, therapeutic skills, and others via interactions between medical students, trainees, and patients. Recently, Hungary has joined such global trends. The first simulated patient program in Hungary was developed at the University of Pécs Medical School in 2019 to aid effective patient-interviewing skills in language and communication classes...
2024: Advances in Medical Education and Practice
#3
JOURNAL ARTICLE
Brenda Abreu Molnar, Laura Levin, Duri Yun, Kimberly Morel, Karen Wiss, Julie Wieser, Christopher Ward, Haley Trice, Maria Teresa Garcia-Romero, Allison Stephenson, Adrienne Provost, Harper N Price, Marissa J Perman, Morgan Moxon, Beth Moeves, Catherine C McCuaig, Christine McCarthy, Anne W Lucky, Moise L Levy, Michelle Lee, Irene Lara-Corrales, Natalia Henner, Nichole Halliburton, Emily Griffith, Emily Gorell, Sharon Glick, Lawrence Eichenfield, Clara Collins, Anna L Bruckner, Brenda Boulrice, Susan Bayliss, Kellie Badger, Amy S Paller
BACKGROUND: Epidermolysis bullosa (EB), characterized by skin fragility and blistering, often requires hospitalization. Training for inpatient management of EB is limited, with no unified recommendations available in North America. OBJECTIVE: To develop consensus-derived best practices for hands-on inpatient management of EB in both the neonatal and post-neonatal period. METHODS: A modified Delphi method (expert-based input via two surveys and a final review) was implemented...
April 9, 2024: Journal of the American Academy of Dermatology
#4
JOURNAL ARTICLE
Lucia Helena da Silva Ferreira Ancillotti, Mauro Henrique Nogueira Guimarães de Abreu, Angélica Maria Cupertino Lopes Marinho, Marcia Pereira Alves Dos Santos
This study validated the content of an instrument designed to assess the knowledge, involvement (attitudes) and management (practice) of dentists relative to sickle-cell disease (KAPD-SCD). The instrument consisted of five domains composed of a total of thirteen items: I. Dentist's self-assessment relative to sickle-cell disease; II. Dentist's knowledge of the repercussions of sickle-cell disease on the stomatognathic system; III. Dentist's knowledge of the complications of sickle-cell disease in the stomatognathic system; IV...
2024: Brazilian Oral Research
#5
JOURNAL ARTICLE
Benjamin L H Jones, Michelle Geier, John Neuhaus, Phillip O Coffin, Hannah R Snyder, Christine S Soran, Kelly R Knight, Leslie W Suen
BACKGROUND: Buprenorphine is an effective treatment for opioid use disorder (OUD); however, buprenorphine initiation can be complicated by withdrawal symptoms including precipitated withdrawal. There has been increasing interest in using low dose initiation (LDI) strategies to reduce this withdrawal risk. As there are limited data on withdrawal symptoms during LDI, we characterize withdrawal symptoms in people with daily fentanyl use who underwent initiation using these strategies as outpatients...
April 9, 2024: Harm Reduction Journal
#6
JOURNAL ARTICLE
Antonia F Langenhoff, Mahesh Srinivasan, Jan M Engelmann
Can the experience of disagreement lead young children to reason in more sophisticated ways? Across two preregistered studies, four- to six-year-old US children (N = 136, 50% female, mixed ethnicities, data collected 2020-2022) experienced either a disagreement or an agreement with a confederate about a causal mechanism after being presented with ambiguous evidence. We measured (1) children's confidence in their belief before and after the (dis)agreement, and (2) how long children searched for information about the correct answer...
April 8, 2024: Child Development
#7
JOURNAL ARTICLE
Stefan Williams, Antonis Kalakoutas, Segun Olusanya, Benedict Schrage, Guido Tavazzi, Anthony P Carnicelli, Santiago Montero, Christophe Vandenbriele, Adriana Luk, Hoong Sern Lim, Sai Bhagra, Sascha C Ott, Marta Farrero, Marc D Samsky, Jamie L W Kennedy, Sounok Sen, Richa Agrawal, Penelope Rampersad, Amanda Coniglio, Federico Pappalardo, Christopher Barnett, Alastair G Proudfoot
BACKGROUND: Observational data suggest that the subset of patients with heart failure related CS (HF-CS) now predominate critical care admissions for CS. There are no dedicated HF-CS randomised control trials completed to date which reliably inform clinical practice or clinical guidelines. We sought to identify aspects of HF-CS care where both consensus and uncertainty may exist to guide clinical practice and future clinical trial design, with a specific focus on HF-CS due to acute decompensated chronic HF...
April 2, 2024: Critical Care: the Official Journal of the Critical Care Forum
#8
REVIEW
Linnea M Wilson, Shoshana J Herzig, Michael A Steinman, Mara A Schonberg, Jennifer L Cluett, Edward R Marcantonio, Timothy S Anderson
BACKGROUND: Management of elevated blood pressure (BP) during hospitalization varies widely, with many hospitalized adults experiencing BPs higher than those recommended for the outpatient setting. PURPOSE: To systematically identify guidelines on elevated BP management in the hospital. DATA SOURCES: MEDLINE, Guidelines International Network, and specialty society websites from 1 January 2010 to 29 January 2024. STUDY SELECTION: Clinical practice guidelines pertaining to BP management for the adult and older adult populations in ambulatory, emergency department, and inpatient settings...
April 2, 2024: Annals of Internal Medicine
#9
JOURNAL ARTICLE
Cameron Englman, Davide Maffei, Clare Allen, Alex Kirkham, Peter Albertsen, Veeru Kasivisvanathan, Ronaldo Hueb Baroni, Alberto Briganti, Pieter De Visschere, Louise Dickinson, Juan Gómez Rivas, Masoom A Haider, Claudia Kesch, Stacy Loeb, Katarzyna J Macura, Daniel Margolis, Anita M Mitra, Anwar R Padhani, Valeria Panebianco, Peter A Pinto, Guillaume Ploussard, Philippe Puech, Andrei S Purysko, Jan Philipp Radtke, Antti Rannikko, Art Rastinehad, Raphaele Renard-Penna, Francesco Sanguedolce, Lars Schimmöller, Ivo G Schoots, Shahrokh F Shariat, Nicola Schieda, Clare M Tempany, Baris Turkbey, Massimo Valerio, Arnauld Villers, Jochen Walz, Tristan Barrett, Francesco Giganti, Caroline M Moore
BACKGROUND AND OBJECTIVE: The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations standardise the reporting of prostate magnetic resonance imaging (MRI) in patients on active surveillance (AS) for prostate cancer. An international consensus group recently updated these recommendations and identified the areas of uncertainty. METHODS: A panel of 38 experts used the formal RAND/UCLA Appropriateness Method consensus methodology...
March 30, 2024: European Urology
#10
JOURNAL ARTICLE
Cindy L Gauvreau, Leighton Schreyer, Paul Gibson, Alicia Koo, Wendy J Ungar, Dean Regier, Kelvin Chan, Robin Hayeems, Jennifer Gibson, Antonia Palmer, Stuart Peacock, Avram E Denburg
OBJECTIVES: Health technology assessment (HTA) does not systematically account for the circumstances and needs of children and youth. To supplement HTA processes, we aimed to develop a child-tailored value assessment framework using a multi-criteria decision analysis (MCDA) approach. METHODS: We constructed an MCDA-based model in multiple phases to create the Comprehensive Assessment of Technologies for Child Health (CATCH) framework. Using a modified Delphi process with stakeholders having broad disciplinary and geographic variation (n=23), we refined previously generated criteria and developed rank-based weights...
March 26, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
#11
JOURNAL ARTICLE
Alexander Light, Nikhil Mayor, Emma Cullen, Alex Kirkham, Anwar R Padhani, Manit Arya, Joyce G R Bomers, Tim Dudderidge, Behfar Ehdaie, Alex Freeman, Stephanie Guillaumier, Richard Hindley, Amish Lakhani, Douglas Pendse, Shonit Punwani, Ardeshir R Rastinehad, Olivier Rouvière, Rafael Sanchez-Salas, Ivo G Schoots, Heminder K Sokhi, Henry Tam, Clare M Tempany, Massimo Valerio, Sadhna Verma, Geert Villeirs, Jan van der Meulen, Hashim U Ahmed, Taimur T Shah
BACKGROUND AND OBJECTIVE: Magnetic resonance imaging (MRI) can detect recurrences after focal therapy for prostate cancer but there is no robust guidance regarding its use. Our objective was to produce consensus recommendations on MRI acquisition, interpretation, and reporting after focal therapy. METHODS: A systematic review was performed in July 2022 to develop consensus statements. A two-round consensus exercise was then performed, with a consensus meeting in January 2023, during which 329 statements were scored by 23 panellists from Europe and North America spanning urology, radiology, and pathology with experience across eight focal therapy modalities...
March 21, 2024: European Urology
#12
JOURNAL ARTICLE
Daniel Gallacher
BACKGROUND: Economic evaluation of emerging health technologies is mandated by agencies such as the National Institute for Health and Care Excellence (NICE) to ensure their cost is proportional to their benefit. To avoid bias, NICE stipulate that the benefit of a treatment is assessed across the lifetime of the patient population, which can be many decades. Unfortunately, follow-up from a clinical trial will not usually cover the required period and the observed follow-up will require extrapolation...
March 14, 2024: BMC Medical Informatics and Decision Making
#13
JOURNAL ARTICLE
Jenifer L Dice, Jean-Michel Brismée, Frédéric P Froment, Janis Henricksen, Rebecca Sherwin, Jan Pool, Nikki Milne, Derek Clewley, Annalie Basson, Kenneth A Olson, Anita R Gross
OBJECTIVE: The aim of this study was to establish international consensus regarding the use of spinal manipulation and mobilisation among infants, children, and adolescents among expert international physiotherapists. METHODS: Twenty-six international expert physiotherapists in manual therapy and paediatrics voluntarily participated in a 3-Round Delphi survey to reach a consensus via direct electronic mail solicitation using Qualtrics®. Consensus was defined a-priori as ≥75% agreement on all items with the same ranking of agreement or disagreement...
March 14, 2024: Journal of Manual & Manipulative Therapy
#14
JOURNAL ARTICLE
Masume Bayat, Seyed Ahmad Raeissadat, Fatemeh Hojjati, Parastoo Faghani, Nima Naseri, Vahid Ghafari
CONTEXT: Diabetes is one of the most common causes of neuropathy. Morbidity and mortality increase in patients suffering from diabetic polyneuropathy and are experienced by approximately 10 to 54% of diabetic patients. Severe pain, loss of sensation, increased risk of ulceration, and even amputation are the complications of diabetic neuropathy. Intradermal injection of botulinum toxin type-A (BTX-A) is a relatively novel method for the treatment of painful diabetic neuropathy. This method is becoming popular considering its acceptable and long-lasting pain control and minimal systemic side effects...
October 2023: Anesthesiology and Pain Medicine
#15
REVIEW
Francesca Tamarozzi, Cristina Mazzi, Spinello Antinori, Marta Arsuaga, Sören L Becker, Emmanuel Bottieau, Daniel Camprubi-Ferrer, Eric Caumes, Alexandre Duvignaud, Martin P Grobusch, Stephane Jaureguiberry, Sabine Jordan, Andreas Mueller, Andreas Neumayr, Jose A Perez-Molina, Joaquin Salas-Coronas, Fernando Salvador, Lina R Tomasoni, Jaap J van Hellemond, Stephen D Vaughan, Linda J Wammes, Lorenzo Zammarchi, Dora Buonfrate, Ralph Huits, Lisette van Lieshout, Federico Gobbi
Terminology in schistosomiasis is not harmonised, generating misunderstanding in data interpretation and clinical descriptions. This study aimed to achieve consensus on definitions of clinical aspects of schistosomiasis in migrants and returning travellers. We applied the Delphi method. Experts from institutions affiliated with GeoSentinel and TropNet, identified through clinical and scientific criteria, were invited to participate. Five external reviewers revised and pilot-tested the statements. Statements focusing on the definitions of acute or chronic; possible, probable, or confirmed; active; and complicated schistosomiasis were managed through REDCap and replies managed in a blinded manner...
March 8, 2024: Lancet Infectious Diseases
#16
JOURNAL ARTICLE
Giovanni Tinelli, Mario D'Oria, Simona Sica, Kevin Mani, Zoran Rancic, Timothy Andrew Resh, Flavia Beccia, Ali Azizzadeh, Marcelo Martins Da Volta Ferreira, Mauro Gargiulo, Sandro Lepidi, Yamume Tshomba, Gustavo S Oderich, Stephan Haulon
OBJECTIVE: Management of follow-up protocols after endovascular aortic repair (EVAR), vary significantly between centres and is not standardized according to the sac regression. By designing an international expert-based Delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. METHODS: Eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified Delphi consensus process...
March 8, 2024: Journal of Vascular Surgery
#17
JOURNAL ARTICLE
Camille Mailho, Benoit Peyronnet, Marianne De Seze, Alexia Even, Maire-Aimée Perrouin-Verbe, Gérard Amarenco, Emmanuel Chartier-Kastler, Loic Le Normand, Andrea Manunta, Gilles Karsenty, Jacques Kerdraon, Alain Ruffion, Christian Saussine, Frédérique Le Breton, Benjamin Bernuz, Evelyne Castel-Lacanal, Pierre Denys, Véronique Phé, Xavier Gamé
INTRODUCTION: Neurogenic detrusor overactivity (NDO) has a major impact on patients' quality of life and can lead to upper urinary tract complications. Intradetrusor botulinum toxin type A injections are administered as second-line treatment to these patients following the failure of anticholinergic agents. The aim of the DETOX 2 study is to propose a consensus definition of the failure of intradetrusor botulinum toxin injections for NDO in patients presenting spinal cord injury, spina bifida, or multiple sclerosis (MS) with self-catheterization...
March 7, 2024: Neurourology and Urodynamics
#18
JOURNAL ARTICLE
Kristen E Rhodin, Steven W Thornton, Harold J Leraas, Catherine B Beckhorn, Adnan Alseidi, Jacob A Greenberg, Kevin N Shah, John Migaly, Elisabeth Tracy
PURPOSE: Surgical subinternships are important rotations for students preparing for a career in general surgery; however, these rotations often vary by institution and service. This modified Delphi study was conducted to reach a consensus set of roles, responsibilities, and expectations of fourth-year medical students on their surgical subinternships. METHOD: Candidate statements on roles, responsibilities, and expectations of subinterns were categorized into 7 domains: rotation structure, rounding and patient care, operating room conduct, technical skills, knowledge base, clinic, and professionalism...
March 5, 2024: Academic Medicine
#19
JOURNAL ARTICLE
Cason Schmit, Alva O Ferdinand, Theodoros Giannouchos, Hye-Chung Kum
OBJECTIVE: In retrospective secondary data analysis studies, researchers often seek waiver of consent from institutional Review Boards (IRB) and minimize risk by utilizing complex software. Yet, little is known about the perspectives of IRB experts on these approaches. To facilitate effective communication about risk mitigation strategies using software, we conducted two studies with IRB experts to co-create appropriate language when describing a software to IRBs. MATERIALS AND METHODS: We conducted structured focus groups with IRB experts to solicit ideas on questions regarding benefits, risks, and informational needs...
April 2024: JAMIA Open
#20
JOURNAL ARTICLE
Ritesh Agarwal, Inderpaul Singh Sehgal, Valliappan Muthu, David W Denning, Arunaloke Chakrabarti, Kathirvel Soundappan, Mandeep Garg, Shivaprakash M Rudramurthy, Sahajal Dhooria, Darius Armstrong-James, Koichiro Asano, Jean-Pierre Gangneux, Sanjay H Chotirmall, Helmut J F Salzer, James D Chalmers, Cendrine Godet, Marcus Joest, Iain Page, Parameswaran Nair, P Arjun, Raja Dhar, Kana Ram Jat, Geethu Joe, Uma Maheswari Krishnaswamy, Joseph L Mathew, Venkata Nagarjuna Maturu, Anant Mohan, Alok Nath, Dharmesh Patel, Jayanthi Savio, Puneet Saxena, Rajeev Soman, Balamugesh Thangakunam, Caroline G Baxter, Felix Bongomin, William J Calhoun, Oliver A Cornely, Jo A Douglass, Chris Kosmidis, Jacques F Meis, Richard Moss, Alessandro C Pasqualotto, Danila Seidel, Rosanne Sprute, Kuruswamy Thurai Prasad, Ashutosh N Aggarwal
BACKGROUND: The ISHAM working group proposed recommendations for managing allergic bronchopulmonary aspergillosis (ABPA) nearly a decade ago. There is a need to update these recommendations due to advances in diagnostics and therapeutics. METHODS: An international expert group was convened to develop guidelines for managing ABPA (caused by Aspergillus spp.) and allergic bronchopulmonary mycosis (ABPM, fungi other than Aspergillus spp.) in adults and children using a modified Delphi method (two online rounds and one in-person meeting)...
March 7, 2024: European Respiratory Journal
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