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https://www.readbyqxmd.com/read/28718506/felbamate-as-an-add-on-therapy-for-refractory-partial-epilepsy
#1
REVIEW
Li Li Shi, JianCheng Dong, HengJian Ni, JinSong Geng, Taixiang Wu
BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews (Issue 7, 2014) on 'Felbamate as an add-on therapy for refractory epilepsy'. Epilepsy is a chronic and disabling neurologic disorder, affecting approximately 1% of the population. Up to 30% of people with epilepsy have seizures that are resistant to currently available drugs. Felbamate is one of the second-generation antiepileptic drugs and we have assessed its effects as an add-on therapy to standard drugs in this review...
July 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28708754/the-effect-of-vasodilatory-medications-on-radial-artery-spasm-in-patients-undergoing-transradial-coronary-artery-procedures-a-systematic-review
#2
Elizabeth Curtis, Ritin Fernandez, Astin Lee
BACKGROUND: The uptake of percutaneous coronary procedures via the radial artery has increased internationally due to the decreased risk of complications and increased patient satisfaction. The increased susceptibility of the radial artery to spasm however presents a potential risk for procedural failure. Although most experts agree on the need for prophylactic medications to reduce radial artery spasm, currently there is inconsistency in literature regarding the most effective vasodilatory medication or combination of medications...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28707962/towards-an-individualized-management-strategy-for-patients-with-chronic-venous-disease-results-of-a-delphi-consensus
#3
S K van der Velden, R R van den Bos, O Pichot, T Nijsten, Mgr De Maeseneer
Objective To obtain consensus on management criteria for symptomatic patients with chronic venous disease (CVD; C2-C6) and superficial venous reflux. Method We used a Delphi method by means of 36 statements sent by email to experts in the field of phlebology across the world over the course of three rounds. The statements addressed criteria for different venous treatments in patients with different characteristics (e.g. extensive comorbidities, morbid obesity and peripheral arterial disease). If at least 70% of the ratings for a specific statement were between 6 and 9 (agreement) or between 1 and 3 (disagreement), experts' consensus was reached...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28706087/periconception-endogenous-and-exogenous-maternal-sex-steroid-hormones-and-risk-of-asthma-and-allergy-in-offspring-protocol-for-a-systematic-review-and-meta-analysis
#4
Merhunisa Talovic, Aziz Sheikh, Nicola McCleary, Maijaliisa Erkkola, Minna Kaila, Suvi M Virtanen, Bright I Nwaru
INTRODUCTION: Pregnancy is associated with several hormonal changes which influence the developing fetus. Variations in maternal endogenous hormones and prepregnancy use of hormonal preparations have been linked to asthma and allergy in the offspring, but findings are inconsistent. We plan to undertake a systematic review to synthesise the evidence on the association between endogenous and exogenous maternal sex hormones and the risk of asthma and allergy in the offspring. METHODS AND ANALYSIS: We will search Medline, Embase, Cochrane Library, Institute of Scientific Information Web of Science, Cumulative Index of Nursing and Allied Health, Scopus, Google Scholar, Allied and Complementary Medicine Database, Global Health, Psychological Information (PsycINFO), Centre for Agriculture and Bioscience (CAB) International and WHO Global Health Library from inception until 2016 to identify relevant studies on the topic...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28686809/decision-making-in-nice-single-technological-appraisals-how-does-nice-incorporate-patient-perspectives
#5
Ferhana Hashem, Michael W Calnan, Patrick R Brown
CONTEXT: The National Institute for Health and Care Excellence (NICE) has an explicit mandate to include patient and public involvement in the appraisal of medicines to be available for funding on the NHS. NICE involves an appraisal committee who are required to take on board experiential evidence from patient experts alongside population-based evidence on clinical and cost-effectiveness when making a decision whether to fund a drug. OBJECTIVE: This paper considers how NICE Single Technological Appraisal (STA) committees attempt to incorporate the views of patients in making decisions about funding medicines on the NHS...
July 7, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28675683/pediatric-cancer-pathology-review-from-a-single-institution-neuropathology-expert-opinion-is-essential-for-accurate-diagnosis-of-pediatric-brain-tumors
#6
Zeina Merabi, Fouad Boulos, Teresa Santiago, Jesse Jenkins, Miguel Abboud, Samar Muwakkit, Nidale Tarek, Ghazi Zaatari, Sima Jeha, Hassan El-Solh, Raya Saab
BACKGROUND AND OBJECTIVES: Second pathology review has been reported to improve accuracy in oncologic diagnoses, including pediatric malignancies. We assessed the impact of second review on the diagnosis of pediatric malignancies at a tertiary care referral center in Beirut, Lebanon. METHODS: Pathology reports of patients treated at the Children's Cancer Institute in Lebanon were retrospectively reviewed for the period 2008-2016 and compared with same samples' diagnoses at St...
July 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28667229/corticosteroids-in-sepsis-an-updated-systematic-review-and-meta-analysis-protocol
#7
Bram Rochwerg, Simon Oczkowski, Reed Alexander Siemieniuk, Kusum Menon, Wojciech Szczeklik, Shane English, Thomas Agoritsas, Emilie Belley-Cote, Frédérick D'Aragon, Waleed Alhazzani, Erick Duan, Kira Gossack-Keenan, Jon Sevransky, Per Vandvik, Bala Venkatesh, Gordon Guyatt, Djillali Annane
INTRODUCTION: Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28659183/what-determines-the-effects-and-costs-of-breast-cancer-screening-a-protocol-of-a-systematic-review-of-reviews
#8
O Mandrik, O I Ekwunife, N Zielonke, F Meheus, J L Severens, S K Lhachimi, R Murillo
BACKGROUND: Multiple reviews demonstrated high variability in effectiveness and cost-effectiveness outcomes among studies on breast cancer screening (BCS) programmes. No study to our knowledge has summarized the current evidence on determinants of effectiveness and cost-effectiveness of the most used BCS approaches or tried to explain differences in conclusions of systematic reviews on this topic. Based on published reviews, this systematic review aims to assess the degree of variability of determinants for (a) effectiveness and (b) cost-effectiveness of BCS programmes using mammography, clinical breast examination, breast self-examination, ultrasonography, or their combinations among the general population...
June 28, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28644548/repetitive-peripheral-magnetic-stimulation-for-activities-of-daily-living-and-functional-ability-in-people-after-stroke
#9
REVIEW
Ryo Momosaki, Naoki Yamada, Erika Ota, Masahiro Abo
BACKGROUND: Repetitive peripheral magnetic stimulation (rPMS) is a form of therapy that creates painless stimulation of deep muscle structures to improve motor function in people with physical impairment from brain or nerve disorders. Use of rPMS for people after stroke has been identified as a feasible approach to improve activities of daily living and functional ability. However, no systematic reviews have assessed the findings of available trials. The effect and safety of this intervention for people after stroke currently remain uncertain...
June 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28638424/application-of-fuzzy-delphi-in-the-selection-of-copd-risk-factors-among-steel-industry-workers
#10
Rahmat Dapari, Halim Ismail, Rosnah Ismail, Noor Hassim Ismail
BACKGROUND: The Delphi method has been widely applied in many study areas to systematically gather experts' input on particular topic. Recently, it has become increasingly well known in health related research. This paper applied the Fuzzy Delphi method to enhance the validation of a questionnaire pertaining chronic obstructive pulmonary disease (COPD) risk factors among metal industry workers. MATERIALS AND METHODS: A detailed, predefined list of possible risk factors for COPD among metal industry workers was created through a comprehensive and exhaustive review of literature from 1995 to 2015...
2017: Tanaffos
https://www.readbyqxmd.com/read/28637137/development-and-acceptability-testing-of-decision-trees-for-self-management-of-prosthetic-socket-fit-in-adults-with-lower-limb-amputation
#11
Daniel Joseph Lee, Diana A Veneri
PURPOSE: The most common complaint lower limb prosthesis users report is inadequacy of a proper socket fit. Adjustments to the residual limb-socket interface can be made by the prosthesis user without consultation of a clinician in many scenarios through skilled self-management. Decision trees guide prosthesis wearers through the self-management process, empowering them to rectify fit issues, or referring them to a clinician when necessary. This study examines the development and acceptability testing of patient-centered decision trees for lower limb prosthesis users...
February 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28629486/the-collaboration-of-general-practitioners-and-nurses-in-primary-care-a-comparative-analysis-of-concepts-and-practices-in-slovenia-and-spain
#12
Kerstin Hämel, Carina Vössing
Aim A comparative analysis of concepts and practices of GP-nurse collaborations in primary health centres in Slovenia and Spain. BACKGROUND: Cross-professional collaboration is considered a key element for providing high-quality comprehensive care by combining the expertise of various professions. In many countries, nurses are also being given new and more extensive responsibilities. Implemented concepts of collaborative care need to be analysed within the context of care concepts, organisational structures, and effective collaboration...
June 20, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28629343/comparative-effectiveness-research-what-to-do-when-experts-disagree-about-risks
#13
Reidar K Lie, Francis K L Chan, Christine Grady, Vincent H Ng, David Wendler
BACKGROUND: Ethical issues related to comparative effectiveness research, or research that compares existing standards of care, have recently received considerable attention. In this paper we focus on how Ethics Review Committees (ERCs) should evaluate the risks of comparative effectiveness research. MAIN TEXT: We discuss what has been a prominent focus in the debate about comparative effectiveness research, namely that it is justified when "nothing is known" about the comparative effectiveness of the available alternatives...
June 19, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28627249/astrology-in-court-the-spanish-inquisition-authority-and-expertise
#14
Tayra M C Lanuza-Navarro
Astrology, its legitimacy, and the limits of its acceptable practice were debated in sixteenth- and seventeenth-century Europe. Many of the related arguments were mediated by the work of Giovanni Pico della Mirandola and the responses to it. Acknowledging the complexities of the relationship between astrological ideas and Christian teachings, this paper focuses on the Catholic debates by specifically considering the decisions about astrology taken by the Spanish Inquisition. The trials of astrologers are examined with the aim of understanding the role of experts in astrology in early modern Spain...
June 1, 2017: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28623455/-single-incision-laparoscopy-current-status
#15
REVIEW
H Weiss, C Mittermair, M Weiss
BACKGROUND: Since the introduction of single incision laparoscopy (SIL), there has been disagreement among professional societies regarding a general recommendation for the use of this minimally invasive method. OBJECTIVES: Determination of evidence-based advantages of SIL compared to multiport laparoscopy (MPL). MATERIALS AND METHODS: Description of recent technical developments and evaluation of prospective randomized clinical trials and valid meta-analyses with regard to organ-specific procedures...
June 16, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28612620/sampus-meltump-and-thimump-diagnostic-categories-characterized-by-uncertain-biological-behavior
#16
L Roncati, F Piscioli, T Pusiol
In the dermatopathological practice, there is a group of atypical melanocytic lesions with borderline histological features between benign simulants and malignant melanoma (MM), due to conflicting diagnostic criteria and inter-observer disagreement. In these cases, the dermatopathologist is authorized to seek consult with an established expert in the field, but even the most experienced specialist may not be sure about the correct diagnosis and the subsequent biological behavior. There is general consensus among qualified dermatopathologists that can be helpful to insert these ambiguous cases into two diagnostic categories: SAMPUS (Superficial Atypical Melanocytic Proliferations of Unknown Significance) and MELTUMP (MELanocytic Tumors of Uncertain Malignant Potential)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28606201/the-writer-s-guide-to-education-scholarship-in-emergency-medicine-systematic-reviews-and-the-scholarship-of-integration-part-4
#17
Aleisha Murnaghan, Kristen Weersink, Brent Thoma, Andrew K Hall, Teresa Chan
OBJECTIVE: Reviews help scholars consolidate evidence and guide their educational practice. However, few papers describe how to effectively publish review papers. We completed a scoping review to develop a set of quality indicators that will assist junior authors to publish reviews and integrative scholarship. METHODS: MEDLINE, Embase, ERIC, and Google Scholar were searched for English language articles published between 2012 and January 2016 using the terms review, medical education, how to publish, and emergency medicine...
June 13, 2017: CJEM
https://www.readbyqxmd.com/read/28601818/protocol-for-a-qualitative-synthesis-of-barriers-and-facilitators-in-implementing-guidelines-for-diagnosis-of-tuberculosis
#18
Eleanor Ochodo, Tamara Kredo, Taryn Young, Charles Shey Wiysonge
INTRODUCTION: Despite the introduction of new tests and guidelines for diagnosis of tuberculosis (TB), worldwide case detection rate of TB is still suboptimal. This could be in part explained by the poor implementation of TB diagnostic guidelines. We aim to identify, appraise and synthesise qualitative evidence exploring the barriers and facilitators to implementing TB diagnostic guidelines. METHODS AND ANALYSIS: A systematic review of qualitative studies will be conducted...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28567798/management-for-intussusception-in-children
#19
REVIEW
Steven Gluckman, Jonathan Karpelowsky, Angela C Webster, Richard G McGee
BACKGROUND: Intussusception is a common abdominal emergency in children with significant morbidity. Prompt diagnosis and management reduces associated risks and the need for surgical intervention. Despite widespread agreement on the use of contrast enema as opposed to surgery for initial management in most cases, debate persists on the appropriate contrast medium, imaging modality, pharmacological adjuvant, and protocol for delayed repeat enema, and on the best approach for surgical management for intussusception in children...
June 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28552520/atherogenic-dyslipidemia-in-latin-america-prevalence-causes-and-treatment-expert-s-position-paper-made-by-the-latin-american-academy-for-the-study-of-lipids-alalip-endorsed-by-the-inter-american-society-of-cardiology-iasc-the-south-american-society-of-cardiology
#20
Carlos I Ponte-Negretti, Jesus E Isea-Perez, Alberto J Lorenzatti, Patricio Lopez-Jaramillo, Fernando Stuardo Wyss-Q, Xavier Pintó, Fernando Lanas, Josefina Medina, Livia T Machado-H, Monica Acevedo, Paola Varleta, Alfonso Bryce, Carlos Carrera, Carlos Ernesto Peñaherrera, José Ramón Gómez-M, Alfredo Lozada, Alonso Merchan-V, Daniel Piskorz, Enrique Morales, Maria Paniagua, Félix Medina-Palomin, Raul Alejandro Villar-M, Leonardo Cobos, Enrique Gómez-Alvares, Rodrigo Alonso, Juan Colan, Julio Chirinos, Jofre Lara, Vladimir Ullauri, Ildefonso Arocha
This is an executive summary made by a group of experts named Latin American Academy for the study of Lipids (ALALIP). In the current clinical guidelines, atherogenic dyslipidemia (AD) is a poorly recognized entity. Due to the frequent lipid alterations associated with AD in Latin America (LA), we organized a group of experts named (ALALIP) to generate a document in order to analyze their prevalence and to offer practical recommendations. METHODOLOGY: using the Delphi methodology, we conducted a comprehensive literature review with emphasis on those publications related to LA...
September 15, 2017: International Journal of Cardiology
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