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Marie-Laure Erffelinck, Alain Goossens
Plants are sessile organisms. Therefore, they developed the capacity to quickly respond to biotic and abiotic environmental stresses, for instance by producing a broad spectrum of bioactive specialized metabolites. In this defense response, the jasmonate phytohormones can instigate a signaling cascade that leads to the specific elicitation and reprograming of numerous metabolic pathways. Recent research progress has provided several insights into the regulatory networks of many specialized metabolic pathways, mainly at the transcriptional level...
June 15, 2018: Planta Medica
Gabrielle do Amaral E Silva Müller, Karim Hahn Lüchmann, Guilherme Razzera, Guilherme Toledo-Silva, Maria João Bebianno, Maria Risoleta Freire Marques, Afonso Celso Dias Bainy
Diesel fuel water-accommodated fraction (diesel-WAF) is a complex mixture of organic compounds that may cause harmful effects to marine invertebrates. Expression of microsomal proteins can be changed by oil exposure, causing functional alterations in endoplasmic reticulum (ER). The aim of this study was to investigate changes in protein expression signatures in microsomes of oysterl Crassostrea brasiliana (=C.gasar) gill after exposure to 10% diesel-WAF for 24 and 72 h. Protein expression signatures of gills of oysters exposed to diesel-WAF were compared to those of unexposed oysters using two-dimensional electrophoresis (2-DE) to identify differentially expressed proteins...
June 6, 2018: Aquatic Toxicology
Timothy F Musial, Elizabeth Molina-Campos, Linda A Bean, Natividad Ybarra, Ronen Borenstein, Matthew L Russo, Eric W Buss, Daniel Justus, Krystina M Neuman, Gelique D Ayala, Sheila A Mullen, Yuliya Voskobiynyk, Christopher T Tulisiak, Jasmine A Fels, Nicola J Corbett, Gabriel Carballo, Colette D Kennedy, Jelena Popovic, Josefina Ramos-Franco, Michael Fill, Melissa R Pergande, Jeffrey A Borgia, Grant T Corbett, Kalipada Pahan, Ye Han, Dane M Chetkovich, Robert J Vassar, Richard W Byrne, M Matthew Oh, Travis R Stoub, Stefan Remy, John F Disterhoft, Daniel A Nicholson
Voltage-gated ion channels are critical for neuronal integration. Some of these channels, however, are misregulated in several neurological disorders, causing both gain- and loss-of-function channelopathies in neurons. Using several transgenic mouse models of Alzheimer's disease (AD), we find that sub-threshold voltage signals strongly influenced by hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels progressively deteriorate over chronological aging in hippocampal CA1 pyramidal neurons. The progressively degraded signaling via HCN channels in the transgenic mice is accompanied by an age-related global loss of their non-uniform dendritic expression...
June 12, 2018: Neurobiology of Learning and Memory
Dong Gil Lee, Min Kyoung Kam, Kyung Min Kim, Han Seop Kim, Oh-Shin Kwon, Hyun-Shik Lee, Dong-Seok Lee
Iron is an essential element for neuronal as well as cellular functions. However, Iron overload has been known to cause neuronal toxicity through mitochondrial fission, dysregulation of Ca2+ , endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS) production. Nevertheless, the precise mechanisms of iron-induced oxidative stress and mitochondria- and ER-related iron toxicity in neuronal cells are not fully understood. In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells...
June 12, 2018: International Journal of Biochemistry & Cell Biology
Lirit N Franks, Benjamin M Ford, Toshifumi Fujiwara, Haibo Zhao, Paul L Prather
Selective estrogen receptor modulators (SERMs) target estrogen receptors (ERs) to treat breast cancer and osteoporosis. Several SERMs exhibit anti-cancer activity not related to ERs. To discover novel anti-cancer drugs acting via ER-independent mechanisms, derivatives of the SERM tamoxifen, known as the "ridaifen" compounds, have been developed that exhibit reduced or no ER affinity, while maintaining cytotoxicity. Tamoxifen and other SERMs bind to cannabinoid receptors with moderate affinity. Therefore, ER-independent effects of SERMs might be mediated via cannabinoid receptors...
June 12, 2018: Toxicology and Applied Pharmacology
Martijn Kerkhofs, Bruno Seitaj, Hristina Ivanova, Giovanni Monaco, Geert Bultynck, Jan B Parys
Ca2+ signaling governs a diverse range of cellular processes and, as such, is subject to tight regulation. A main component of the complex intracellular Ca2+ -signaling network is the inositol 1,4,5-trisphosphate (IP3 ) receptor (IP3 R), a tetrameric channel that mediates Ca2+ release from the endoplasmic reticulum (ER) in response to IP3 . IP3 R function is controlled by a myriad of factors, such as Ca2+ , ATP, kinases and phosphatases and a plethora of accessory and regulatory proteins. Further complexity in IP3 R-mediated Ca2+ signaling is the result of the existence of three main isoforms (IP3 R1, IP3 R2 and IP3 R3) that display distinct functional characteristics and properties...
June 12, 2018: Biochimica et Biophysica Acta
Jing Liu, Jia-Xin Shen, Hua-Tao Wu, Xiao-Li Li, Xiao-Fen Wen, Cai-Wen Du, Guo-Jun Zhang
PURPOSE: Extracellular matrix (ECM) is an important component of tumor microenvironment and plays critical roles in cancer development and metastasis, in which collagen is the major structural protein. Collagen type I alpha 1 (COL1A1) is reportedly associated with the development of several human diseases. However, the functions and mechanisms of cellular expression of COL1A1 in breast cancer remain unknown. The purpose of this study is to investigate the cellular expression of COL1A1 in breast cancer cells and patients, and its role in the development and metastasis of breast cancer...
May 2018: Discovery Medicine
Sachin Choudhary, Amol Prakash Pawar, Jyothi Yadav, Devinder Kumar Sharma, Rajni Kant, Indresh Kumar
An efficient protocol for the catalytic asymmetric synthesis of new dibenzo[b,f][1,4]-oxazepine fused-1,2-dihydropyridines (DHPs) has been described under metal-free conditions. This reaction proceeds through proline-catalyzed direct Mannich/cyclization between seven-membered dibenzo[b,f][1,4]-oxazepine-imines and aqueous glutaraldehyde, followed by IBX-mediated site-selective dehydrogenative-oxidation in one pot operation with high yield's (up to 92%) and excellent enantioselectivity (up to >99:1 er).
June 15, 2018: Journal of Organic Chemistry
Philipp Paul Hallmen, Guntram Rauhut, Hermann Stoll, Alexander O Mitrushchenkov, Joris van Slageren
State-averaged complete active space self-consistent field (CASSCF) calculations and a subsequent spin-orbit calculation mixing the CASSCF wave functions (CASSCF/state-interaction with spin-orbit coupling) is the conventional approach used for ab initio calculations of crystal-field splittings and magnetic properties of lanthanide complexes. However, this approach neglects dynamical correlation. Complete active space second-order perturbation theory (CASPT2) can be used to account for dynamical correlation, but suffers from the well-known problems of multireference perturbation theory, e...
June 15, 2018: Journal of Chemical Theory and Computation
Yidan Liang, Xudong Che, Qing Zhao, Rami Darwazeh, Hongxia Zhang, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Wang Qin, Liu Liu, Zhaohui He
Early brain injury (EBI) was reported to be the primary cause of high mortality and poor outcomes in subarachnoid hemorrhage (SAH) patients, and apoptosis is regarded as the most important physiopathologic mechanism during EBI. Recently, our team found that thioredoxin-interacting protein (TXNIP) links endoplasmic reticulum stress (ER stress) to neuronal apoptosis and aggravates EBI. However, the other underlying mechanisms remain unknown. Mitochondria are considered to be the central points in integrating apoptotic cell death...
June 15, 2018: Molecular and Cellular Biochemistry
Michael F Schmalz, Ines Wieser, Felix Schindler, Christina Czada, Alfred Leitenstorfer, Elisa Ferrando-May
We present a three-color femtosecond Er/Yb:fiber laser enabling highly specific and standardized nonlinear optical manipulation of live cells. The system simultaneously provides bandwidth-limited 80-fs pulses with identical intensity envelope centered at wavelengths of 515, 775, and 1035 nm in the focus of a confocal microscope. We achieve this goal by combining high-order dispersion control via, for example, chirped fiber Bragg gratings with proper bandwidth management in each nonlinear conversion step. Wavelength-selective and noninterfering induction of deoxyribonucleic acid (DNA) photoproducts and DNA strand breaks, as well as fluorescence photoactivation of a photoactivatable green fluorescent protein (PA-GFP)-histone fusion protein, are demonstrated...
June 15, 2018: Optics Letters
Yang Ran, Zhiyuan Xu, Furong Feng, Peng Xiao, Yizhi Liang, Long Jin, Bai-Ou Guan
A dual-wavelength fiber laser is proposed by the use of Er/Yb co-doped active fiber and a pair of novel Bragg-grating reflectors. The Bragg grating presents strong reflections of both third and second harmonics in accordance with the gain of ytterbium and erbium ion, respectively, enabling the laser emitted at 1.06 μm and 1.55 μm wavebands simultaneously with a short linear cavity structure. Adjusting reflectivity of the harmonics in the grating can influence the intensity contrast of the two lasing signals...
June 15, 2018: Optics Letters
Kinga Grzech-Leśniak, Jacek Matys, Dorota Żmuda-Stawowiak, Krzysztof Mroczka, Marzena Dominiak, Aldo Brugnera Junior, Reinhard Gruber, Georgios E Romanos, Anton Sculean
OBJECTIVE: To evaluate the effects of bracket removal using an erbium laser on the pulp temperature and enamel surface. BACKGROUND: Removal of orthodontic brackets with conventional debonding pliers may result in enamel cracks. To avoid damage to the enamel surface and effectively remove metal or ceramic brackets, different types of lasers, such as Nd:YAG, CO2 , TM:YAP, diode laser, or Er:YAG, have been introduced for debonding. MATERIALS AND METHODS: A total of 55 brackets (n = 55; 20 metal and 35 ceramic ones) were bonded to 55 caries-free premolars extracted for orthodontic indications...
June 15, 2018: Photomedicine and Laser Surgery
Emre Korkut, Emrah Torlak, Onur Gezgin, Hazal Özer, Yağmur Şener
OBJECTIVE: The objective of this study was to compare antibacterial and smear layer removal efficacy of the erbium:yttrium-aluminium-garnet (Er:YAG) laser irradiation by photon-induced photoacoustic streaming (PIPS), neodymium:yttrium-aluminium-garnet (Nd:YAG), and diode lasers and conventional irrigation agent in primary molar root canals. BACKGROUND: The selection, application, and activation of the irrigant are important factors affecting the success of the endodontic treatment...
June 15, 2018: Photomedicine and Laser Surgery
Fengfeng Guo, Xiaobo Yu, Haiyue Jiang
Objective: To summarize the current progress of laser-assisted cartilage reshaping (LACR) for prominent ear. Methods: The domestic and abroad article concerning the LACR in treatment of prominent ear was reviewed and analyzed. Results: As a new technique, there were three types of LACR therapies that been used for prominent ear. LACR with the 1 064 nm Nd/YAG laser is painful and the penetration depth of the 1 064 nm Nd/YAG laser is greater than that of the 1540 nm Er/Glass laser which is caused more tissue injury...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Xue Chen, Yingjian He, Jiwei Wang, Ling Huo, Zhaoqing Fan, Jinfeng Li, Yuntao Xie, Tianfeng Wang, Tao Ouyang
Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography-negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database...
June 14, 2018: Cancer Medicine
Nobuaki Sato, Norikazu Masuda, Takashi Morimoto, Takayuki Ueno, Chizuko Kanbayashi, Koji Kaneko, Hiroyuki Yasojima, Shigehira Saji, Hironobu Sasano, Satoshi Morita, Shinji Ohno, Masakazu Toi
Patients with estrogen receptor (ER)-positive breast cancer are less likely to achieve a pathological complete response (pCR) with neoadjuvant chemotherapy. Neoadjuvant endocrine therapy may be more appropriate than neoadjuvant chemotherapy in these hormone-sensitive patients. Most patients with ER-positive breast cancer are postmenopausal, and therefore, generally older and less able to tolerate chemotherapy. We aimed to investigate the efficacy and safety of tailored neoadjuvant endocrine and chemoendocrine therapy for postmenopausal breast cancer patients...
June 14, 2018: Cancer Medicine
Mohd Hariri Arifin, John Stephen Kayode, Muhammad Azrief Azahar, Habibah Jamil, Saznira Fadila Ahmad Sabri
The paper presents the data from the surface and subsurface mapping of this area for the purpose of siting industrial city in the area. The field data collected combine with the borehole data was to successfully apply these to solving geological, environmental and engineering complications posed by the complexity of the subsurface geological structures underlain this area. The Electrical Resistivity, (ER) and Induced Polarization, (IP) data were initially processed using RES2DINV software model to generate the depth to the lithological units together with topographic correction...
June 2018: Data in Brief
Zhuangwei Lv, Min Liu, Jinghui Shen, Dong Xiang, Yunfeng Ma, Yanhong Ji
Interleukin-10 (IL-10), interleukin-17A (IL-17A) and transforming growth factor α (TGF-α) have been implicated in the progression of breast cancer. However, the diagnostic and prognostic roles of these cytokines in ductal carcinoma remain unclear. The present study therefore aimed to determine the serum levels of IL-10, IL-17 and TGF-α in subjects with benign and malignant breast diseases and to evaluate the clinical significance of these cytokines in ductal carcinoma. Pre-operative serum samples were collected from 378 patients with breast disease and 70 healthy subjects...
June 2018: Experimental and Therapeutic Medicine
Deng'e Xie, Chen Lu, Ying Zhu, Sulan Zhu, Er-Jiang Yang, Xin Jin
We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied...
June 2018: Experimental and Therapeutic Medicine
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