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https://www.readbyqxmd.com/read/29677538/improvement-effects-of-a-mixed-extract-of-flowers-of-pueraria-thomsonii-benth-and-peels-of-citrus-unshiu-markovich-on-postmenopausal-symptoms-of-ovariectomized-mice
#1
Na-Ra Han, Sun-Young Nam, Sungwei Hong, Hee-Yun Kim, Phil-Dong Moon, Hyeong-Jin Kim, Hosong Cho, Boyoung Lee, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677492/substrate-insolubility-dictates-hsp104-dependent-endoplasmic-reticulum-associated-degradation
#2
G Michael Preston, Christopher J Guerriero, Meredith B Metzger, Susan Michaelis, Jeffrey L Brodsky
Misfolded proteins in the endoplasmic reticulum (ER) are destroyed by ER-associated degradation (ERAD). Although the retrotranslocation of misfolded proteins from the ER has been reconstituted, how a polypeptide is initially selected for ERAD remains poorly defined. To address this question while controlling for the diverse nature of ERAD substrates, we constructed a series of truncations in a single ER-tethered domain. We observed that the truncated proteins exhibited variable degradation rates and discovered a positive correlation between ERAD substrate instability and detergent insolubility, which demonstrates that aggregation-prone species can be selected for ERAD...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29677253/in-type-2-diabetes-weekly-semaglutide-reduced-hba1c-and-increased-weight-loss-more-than-weekly-exenatide-er
#3
Eleni Bekiari, Thomas Karagiannis, Apostolos Tsapas
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29676829/er-stress-mediated-autophagy-protects-against-%C3%AE-%C3%AE-dimethylacrylshikonin-induced-apoptosis-in-lung-adenocarcinoma-cells
#4
Haibing Wang, Gaochenxi Zhang
β,β-Dimethylacrylshikonin (DMAS) is an anti-cancer compound extracted from the roots of Lithospermum erythrorhizon. This study aims to investigate the effects of DMAS on human lung adenocarcinoma cells in vitro and explored the mechanisms of its anti-cancer action. We demonstrated that DMAS markedly inhibited cell viability in a dose- and time-dependent manner, and induced apoptosis as well as autophagy in human lung adenocarcinoma cells. Furthermore, we found that DMAS stimulated endoplasmic reticulum (ER) stress and mediated autophagy via the PERK-eIF2α-ATF4-CHOP and IRE1-TRAF2-JNK axises of the unfolded protein response (UPR) in human lung adenocarcinoma cells...
April 20, 2018: Cancer Science
https://www.readbyqxmd.com/read/29676723/paraburkholderia-caseinilytica-sp-nov-isolated-from-the-pine-and-broad-leaf-mixed-forest-soil
#5
Zeng-Hong Gao, Shu-Fen Zhong, Zu-Er Lu, Sen-Yang Xiao, Li-Hong Qiu
A novel Gram-stain-negative, aerobic, non-spore-forming, motile and rod-shaped bacterial strain, designated HM451T , was isolated from forest soil sampled at the Dinghushan Biosphere Reserve, Guangdong Province, PR China (112° 31' E 23° 10' N). It grew optimally at 28 °C, pH 5.0-6.0 and in the presence of 0-2.5 % (w/v) NaCl on R2A medium. Strain HM451T was closely related to Paraburkholderia mimosarum NBRC 106338T (98.6 % 16S rRNA gene sequence similarity), Paraburkholderia heleia NBRC 101817T (98...
April 20, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29676583/reticulocalbin-3-deficiency-in-alveolar-epithelium-exacerbated-bleomycin-induced-pulmonary-fibrosis
#6
Jiawei Jin, Xiaoqian Shi, Yongchao Li, Qianyu Zhang, Yu Guo, Chaokun Li, Pingping Tan, Qiuhong Fang, Yingmin Ma, Runlin Z Ma
Reticulocalbin 3 (Rcn3) is an endoplasmic reticulum (ER) lumen protein localized to the secretory pathway. We have reported that Rcn3 plays critical role for alveolar epithelial cell type II (AECII) maturation during perinatal lung development, but its biological role in the adult lung is largely unknown. Herein, we found marked induction of Rcn3 expression in alveolar epithelium during bleomycin-induced pulmonary fibrosis, which is most obvious in AECIIs. To further examine Rcn3 in pulmonary injury-remodeling, we generated transgenic mice to selectively delete Rcn3 in AECIIs in adulthood...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29676576/enantioselective-decarboxylative-propargylation-hydroamination-enabled-by-organo-metal-cooperative-catalysis
#7
Yu-Chen Zhang, Zi-Jing Zhang, Lian-Feng Fan, Jin Song
The first catalytic enantioselective decarboxylative propargylation/hydroamination reaction of ethynyl benzoxazinanones with malononitriles enabled by organo/copper cooperative catalysis was established. Various 3-indolin-malononitrile derivatives, displaying a high tolerance for functional groups, could be obtained in good yields with high levels of enantioselectivity (up to 85% yield, 96:4 er). More importantly, this organo/metal cooperative catalytic system will provide a powerful synthetic strategy for new reaction development...
April 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29676568/toward-rechargeable-persistent-luminescence-for-the-first-and-third-biological-windows-via-persistent-energy-transfer-and-electron-trap-redistribution
#8
Jian Xu, Daisuke Murata, Jumpei Ueda, Bruno Viana, Setsuhisa Tanabe
Persistent luminescence (PersL) imaging without real-time external excitation has been regarded as the next generation of autofluorescence-free optical imaging technology. However, to achieve improved imaging resolution and deep tissue penetration, developing new near-infrared (NIR) persistent phosphors with intense and long duration PersL over 1000 nm is still a challenging but urgent task in this field. Herein, making use of the persistent energy transfer process from Cr3+ to Er3+ , we report a novel garnet persistent phosphor of Y3 Al2 Ga3 O12 codoped with Er3+ and Cr3+ (YAG G:Er-Cr), which shows intense Cr3+ PersL (∼690 nm) in the deep red region matching well with the first biological window (NIR-I, 650-950 nm) and Er3+ PersL (∼1532 nm) in the NIR region matching well with the third biological window (NIR-III, 1500-1800 nm)...
April 20, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29676422/yb-3-can-be-much-better-than-dy-3-smm-properties-and-controllable-self-assembly-of-novel-lanthanide-3-5-dinitrobenzoate-acetylacetonate-complexes
#9
Andrey V Gavrikov, Nikolay N Efimov, Andrey B Ilyukhin, Zhanna V Dobrokhotova, Vladimir M Novotortsev
The first representatives of the binuclear lanthanide 3,5-dinitrobenzoate-acetylacetonate complexes, namely isostructural compounds [Ln(dnbz)(acac)2(H2O)(EtOH)]2 (Ln = Eu (1), Gd (2), Tb (3), Dy (4), Ho (5), Er (6), Tm (7), and Yb (8); dnbz - 3,5-dinitrobenzoate anion; acac - acetylacetonate (pentane-2,4-dionate) anion) were prepared and characterized. The SMM behavior of the Yb compound 8 was shown to be surprisingly less sensitive to the composition of the Yb3+ coordination environment in comparison with that of the Dy derivative...
April 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29676259/mfn2-ubiquitination-by-pink1-parkin-gates-the-p97-dependent-release-of-er-from-mitochondria-to-drive-mitophagy
#10
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a rapid burst of Mfn2 phosphoubiquitination to trigger p97-dependent disassembly of Mfn2 complexes from the outer mitochondrial membrane, dissociating mitochondria from the ER...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29676234/low-dose-of-acacetin-promotes-breast-cancer-mcf-7-cells-proliferation-through-the-activation-of-erk-pi3k-akt-signaling-pathway
#11
Huanhuan Ren, Jun Ma, Lingling Si, Boxue Ren, Xiaoyu Chen, Dan Wang, Wenjin Hao, Xuexi Tang, Defang Li, Qiusheng Zheng
Background Phytoestrogens has been proposed as a replaceable medicine for climacteric hormone replacement therapy, according to EP3138562, WO/2017/019213 and US5516528. However, recent studies showed that phytoestrogens might promote the proliferation of breast cancer cells and that is associated with their estrogenic activity. Acacetin, as one phytoestrogen, has been reported to exhibit estrogenic activity. But the effects of Acacetin on breast cancer cells proliferation have not been explored Objective In this study, we evaluated the effects of acacetin on breast cancer MCF-7 cells proliferation and explored its possible mechanism...
April 20, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#12
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29675957/endoplasmic-reticulum-stress-induces-spatial-memory-deficits-by-activating-gsk-3
#13
Li Lin, Jie Cao, Shu-Sheng Yang, Zheng-Qi Fu, Peng Zeng, Jiang Chu, Lin-Na Ning, Teng Zhang, Yan Shi, Qing Tian, Xin-Wen Zhou, Jian-Zhi Wang
Endoplasmic reticulum (ER) stress is involved in Alzheimer's disease (AD), but the mechanism is not fully understood. Here, we injected tunicamycin (TM), a recognized ER stress inducer, into the brain ventricle of Sprague-Dawley (SD) rats to induce the unfolded protein response (UPR), demonstrated by the enhanced phosphorylation of pancreatic ER kinase (PERK), inositol-requiring enzyme-1 (IRE-1) and activating transcription factor-6 (ATF-6). We observed that UPR induced spatial memory deficits and impairments of synaptic plasticity in the rats...
April 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29675553/a-potential-strategy-for-treating-atherosclerosis-improving-endothelial-function-via-amp-activated-protein-kinase
#14
REVIEW
Feng Gao, Jiemei Chen, Haibo Zhu
Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase (AMPK) is an important metabolic switch that plays a crucial role in lipid metabolism and inflammation. However, recent evidence indicates that AMPK could be a target for atherosclerosis by improving endothelial function. For instance, activation of AMPK inhibits the production of reactive oxygen species induced by mitochondrial dysfunction, ER stress, and NADPH oxidase...
April 16, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29675512/bonding-performance-of-universal-adhesives-to-eroded-dentin
#15
Fabiana S F Siqueira, Andres Millan Cardenas, Jessica Bedoya Ocampo, Viviane Hass, Matheus Coelho Bandeca, João Carlos Gomes, Alessandra Reis, Alessandro D Loguercio
PURPOSE: To evaluate the microtensile bond strength (μTBS) and nanoleakage (NL) of several universal adhesives to eroded dentin (ED), using etch-and-rinse (ER) or self-etch (SE) strategies, and to characterize the surface using two pH cycling models to erode dentin (citric acid and a soft drink). MATERIALS AND METHODS: Molars were eroded either by soft-drink or citric acid cycling, or were left untreated as control (SD). For each surface, the following adhesives were applied: 1...
April 19, 2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29675402/poor-compliance-with-sepsis-guidelines-in-a-tertiary-care-children-s-hospital-emergency-room
#16
Benjamin Louis Moresco, Clinton Woosley, Morris Sauter, Utpal Bhalala
Objectives: This study aimed to assess factors related to adherence to the Pediatric Advanced Life Support guidelines for severe sepsis and septic shock in an emergency room (ER) of a tertiary care children's hospital. Methods: This was a retrospective, observational study of children (0-18 years old) in The Children's Hospital of San Antonio ER over 1 year with the International Consensus Definition Codes, version-9 (ICD-9) diagnostic codes for "severe sepsis" and "shocks...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29675327/observation-of-laser-induced-elastic-waves-in-agar-skin-phantoms-using-a-high-speed-camera-and-a-laser-beam-deflection-probe
#17
Jernej Laloš, Peter Gregorčič, Matija Jezeršek
We present an optical study of elastic wave propagation inside skin phantoms consisting of agar gel as induced by an Er:YAG (wavelength of 2.94 μm) laser pulse. A laser-beam-deflection probe is used to measure ultrasonic propagation and a high-speed camera is used to record displacements in ablation-induced elastic transients. These measurements are further analyzed with a custom developed image recognition algorithm utilizing the methods of particle image velocimetry and spline interpolation to determine point trajectories, material displacement and strain during the passing of the transients...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674751/characterization-of-the-most-frequent-atp7b-mutation-causing-wilson-disease-in-hepatocytes-from-patient-induced-pluripotent-stem-cells
#18
Silvia Parisi, Elena V Polishchuk, Simona Allocca, Michela Ciano, Anna Musto, Maria Gallo, Lucia Perone, Giusy Ranucci, Raffaele Iorio, Roman S Polishchuk, Stefano Bonatti
H1069Q substitution represents the most frequent mutation of the copper transporter ATP7B causing Wilson disease in Caucasian population. ATP7B localizes to the Golgi complex in hepatocytes but moves in response to copper overload to the endo-lysosomal compartment to support copper excretion via bile canaliculi. In heterologous or hepatoma-derived cell lines, overexpressed ATP7B-H1069Q is strongly retained in the ER and fails to move to the post-Golgi sites, resulting in toxic copper accumulation. However, this pathogenic mechanism has never been tested in patients' hepatocytes, while animal models recapitulating this form of WD are still lacking...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674750/publisher-correction-akt-mtor-signaling-modulates-the-dynamics-of-ire1-rnase-activity-by-regulating-er-mitochondria-contacts
#19
Miguel Sanchez-Alvarez, Miguel Angel Del Pozo, Chris Bakal
A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674681/publisher-correction-msk1-regulates-luminal-cell-differentiation-and-metastatic-dormancy-in-er-breast-cancer
#20
Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique J Arenas, Fernando Salvador, Jelena Urosevic, Cristina Figueras-Puig, Federico Rojo, Ivan Del Barco Barrantes, Juan Miguel Cejalvo, Marta Palafox, Marc Guiu, Antonio Berenguer-Llergo, Aikaterini Symeonidi, Anna Bellmunt, Daniela Kalafatovic, Anna Arnal-Estapé, Esther Fernández, Barbara Müllauer, Rianne Groeneveld, Konstantin Slobodnyuk, Camille Stephan-Otto Attolini, Cristina Saura, Joaquín Arribas, Javier Cortes, Ana Rovira, Montse Muñoz, Ana Lluch, Violeta Serra, Joan Albanell, Aleix Prat, Angel R Nebreda, Salvador Aznar Benitah, Roger R Gomis
In the version of this Article originally published, the boxes framing the two plots in Fig. 1g were misaligned from the axes due to a technical error. This has now been corrected in all versions of the Article.
April 19, 2018: Nature Cell Biology
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