Thomas C Mules, Jeffry S Tang, Francesco Vacca, Bibek Yumnam, Alfonso Schmidt, Brittany Lavender, Kate Maclean, Sophia-Louise Noble, Craig Waugh, Roel van Ginkel, Mali Camberis, Graham Le Gros, Stephen Inns
Increased permeability of the intestinal epithelial layer is linked to the pathogenesis and perpetuation of a wide range of intestinal and extra-intestinal diseases. Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed as a treatment for many of the same diseases. Helminths induce immunoregulatory changes in their host which could decrease epithelial permeability, which is highlighted as a potential mechanism through which helminths treat disease...
April 22, 2024: Immunology and Cell Biology