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https://www.readbyqxmd.com/read/29236333/effect-and-mechanism-of-lncrna-hotair-on-occurrence-and-development-of-gastric-cancer
#1
Xuan Feng, Suiping Huang
OBJECTIVE: In this study, we aimed at looking for the lncRNA abnormally expressed in gastric cancer (GC) tissues, and analyzing the association of its expression level with the clinicopathological feature and patient prognosis. The biological function of this lncRNA in occurrence and development of GC was studied in vivo and in vitro. The underlying molecular mechanism was further discussed. METHODS: We investigated the lncRNA expression level in GC tissues and normal gastric mucosa tissues by lncRNA chips analysis...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236286/corticosteroids-for-pneumonia
#2
REVIEW
Anat Stern, Keren Skalsky, Tomer Avni, Elena Carrara, Leonard Leibovici, Mical Paul
BACKGROUND: Pneumonia is a common and potentially serious illness. Corticosteroids have been suggested for the treatment of different types of infection, however their role in the treatment of pneumonia remains unclear. This is an update of a review published in 2011. OBJECTIVES: To assess the efficacy and safety of corticosteroids in the treatment of pneumonia. SEARCH METHODS: We searched the Cochrane Acute Respiratory Infections Group's Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS on 3 March 2017, together with relevant conference proceedings and references of identified trials...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29236245/-relevance-of-type-of-diagnosis-and-occupational-status-for-the-results-of-psychiatric-rehabilitation
#3
Friedrich Riffer, Manuel Sprung, Lore Streibl, Elmar Kaiser
OBJECTIVE: The specific effectiveness of psychiatric rehabilitation has been confirmed in numerous studies. Of particular interest is to what extend different results can be observed regarding the occupational status and type of mental illness of patients. Unemployment at the start of treatment is generally deemed to be a disadvantage for treatment outcome. Weaker treatment effects have also been reported for some types of mental illnesses, such as pain- und somatoform disorders. METHODS: Results from the evaluation of a sample of 2260 patients form the psychiatric rehabilitation clinic Gars am Kamp were analyzed, with regard to the occupational status and type of mental illness of patients...
December 13, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29236235/potential-biomarkers-of-cdk4-6-inhibitors-in-hormone-receptor-positive-advanced-breast-cancer
#4
REVIEW
Hehui Fang, Doudou Huang, Fang Yang, Xiaoxiang Guan
PURPOSE: Cyclin D/cyclin-dependent kinase 4/6 (CDK4/6) complex inhibitors have recently been proven effective when combined with endocrine therapy in clinical trials. However, the clinical benefit from CDK4/6 inhibitor varied from different patients. In order to optimize the clinical application of CDK4/6 inhibitors, this review focuses on the potential biomarkers applicable to identify patients who will benefit the most from CDK4/6 inhibition. METHODS: We have summarized the clinical trials about addition of CDK4/6 inhibitors to endocrine therapy and reviewed literature currently available on the potential biomarkers in predicting efficacy of CDK4/6 inhibitors...
December 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29236231/dimethyl-fumarate-a-review-in-moderate-to-severe-plaque-psoriasis
#5
Hannah A Blair
Fumaric acid esters (FAEs) have been used in the treatment of psoriasis in some European countries for over 20 years, and are recommended in the European guidelines for the management of moderate to severe plaque psoriasis. Dimethyl fumarate (Skilarence®; hereafter referred to as DMF) is an orally administered FAE indicated for the treatment of moderate to severe plaque psoriasis in adults in need of systemic medicinal therapy; unlike other available FAEs, it is not formulated in combination with monoethyl fumarate salts...
December 13, 2017: Drugs
https://www.readbyqxmd.com/read/29236222/an-indirect-comparison-of-changes-in-the-impact-of-weight-on-quality-of-life-among-subjects-with-type-2-diabetes-treated-with-antihyperglycemic-agents-in-dual-therapy-with-metformin
#6
Shana B Traina, April Slee, Suzy Van Sanden, Joris Diels
INTRODUCTION: It is important to capture the patient experience with a diabetes treatment in clinical trials; however, use of instruments to assess patient-reported outcomes (PROs) in diabetes trials is inconsistent and results may not be reported alongside primary efficacy data. In lieu of head-to-head data, indirect comparisons can be used to compare competing interventions. In this study, we used indirect comparison methods to assess differences in PRO score changes between canagliflozin and other antihyperglycemic agents as add-on to metformin...
December 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29236198/sdf-1-induces-tnf-mediated-apoptosis-in-cardiac-myocytes
#7
Andrew A Jarrah, Martina Schwarskopf, Edward R Wang, Thomas LaRocca, Ashwini Dhume, Shihong Zhang, Lahouria Hadri, Roger J Hajjar, Alison D Schecter, Sima T Tarzami
Chemokines are small secreted proteins with chemoattractant properties that play a key role in inflammation. One such chemokine, Stromal cell-derived factor-1 (SDF-1) also known as CXCL12, and its receptor, CXCR4, are expressed and functional in cardiac myocytes. SDF-1 both stimulates and enhances the cellular signal which attracts potentially beneficial stem cells for tissue repair within the ischemic heart. Paradoxically however, this chemokine is known to act in concert with the inflammatory cytokines of the innate immune response which contributes to cellular injury through the recruitment of inflammatory cells during ischemia...
December 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29236094/hospital-perceptions-of-medicare-s-sepsis-quality-reporting-initiative
#8
Ian J Barbash, Kimberly J Rak, Courtney C Kuza, Jeremy M Kahn
BACKGROUND: In October 2015, the Centers for Medicare and Medicaid Services (CMS) implemented the Sepsis CMS Core Measure (SEP-1) program, requiring hospitals to report data on the quality of care for their patients with sepsis. OBJECTIVE: We sought to understand hospital perceptions of and responses to the SEP-1 program. DESIGN: A thematic content analysis of semistructured interviews with hospital quality officials. SETTING: A stratified random sample of short-stay, nonfederal, general acute care hospitals in the United States...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29236093/trends-in-troponin-only-testing-for-ami-in-academic-teaching-hospitals-and-the-impact-of-choosing-wisely%C3%A2
#9
Micah T Prochaska, Samuel F Hohmann, Matthew Modes, Vineet M Arora
BACKGROUND: Identifying hospitals that are both early and consistent adopters of high-value care can help shed light on the culture and practices at those institutions that are necessary to promote high-value care nationwide. The use of troponin to diagnose acute myocardial infarction (AMI), and not to test for myoglobin or creatine kinase-MB (CK-MB), is a high-value recommendation of the Choosing Wisely® campaign. OBJECTIVE: To examine the variation in cardiac biomarker testing and the effect of the Choosing Wisely® troponin-only recommendation for the diagnosis of AMI...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29236091/noncoding-copy-number-variations-are-associated-with-congenital-limb-malformation
#10
Ricarda Flöttmann, Bjørt K Kragesteen, Sinje Geuer, Magdalena Socha, Lila Allou, Anna Sowińska-Seidler, Laure Bosquillon de Jarcy, Johannes Wagner, Aleksander Jamsheer, Barbara Oehl-Jaschkowitz, Lars Wittler, Deepthi de Silva, Ingo Kurth, Idit Maya, Fernando Santos-Simarro, Wiebke Hülsemann, Eva Klopocki, Roger Mountford, Alan Fryer, Guntram Borck, Denise Horn, Pablo Lapunzina, Meredith Wilson, Bénédicte Mascrez, Denis Duboule, Stefan Mundlos, Malte Spielmann
PurposeCopy-number variants (CNVs) are generally interpreted by linking the effects of gene dosage with phenotypes. The clinical interpretation of noncoding CNVs remains challenging. We investigated the percentage of disease-associated CNVs in patients with congenital limb malformations that affect noncoding cis-regulatory sequences versus genes sensitive to gene dosage effects.MethodsWe applied high-resolution copy-number analysis to 340 unrelated individuals with isolated limb malformation. To investigate novel candidate CNVs, we re-engineered human CNVs in mice using clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing...
October 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29236051/synchrotron-based-pencil-beam-scanning-nozzle-with-an-integrated-mini-ridge-filter-a-dosimetric-study-to-optimize-treatment-delivery
#11
Xianliang Wang, Yupeng Li, Xiaodong Zhang, Heng Li, Koichi Miyazaki, Rintaro Fujimoto, Hiroshi Akiyama, Michael T Gillin, Falk Poenisch, Narayan Sahoo, David Grosshans, Brandon Gunn, Steven Jay Frank, Pei Wang, Jinyi Lang, Qing Hou, Xiaorong Ronald Zhu
A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies. To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle (IMRF). Dose models with and without IMRF were commissioned in a commercial Treatment planning system (TPS). Dosimetric characteristics in a homogenous water phantom were compared between plans with and without IMRF for a fixed spread-out Bragg peak width of 4 cm with distal ranges varying from 8 to 30 g/cm²...
December 13, 2017: Cancers
https://www.readbyqxmd.com/read/29236038/adverse-effects-of-amoxicillin-for-acute-lower-respiratory-tract-infection-in-primary-care-secondary-and-subgroup-analysis-of-a-randomised-clinical-trial
#12
Meera Tandan, Akke Vellinga, Robin Bruyndonckx, Paul Little, Theo Verheij, Chris C Butler, Herman Goossens, Samuel Coenen
A European placebo-controlled trial of antibiotic treatment for lower respiratory tract infection (LRTI) conducted in 16 primary care practices networks recruited participants between November 2007 and April 2010, and found adverse events (AEs) occurred more often in patients prescribed amoxicillin compared to placebo. This secondary analysis explores the causal relationship and estimates specific AEs (diarrhoea, nausea, rash) due to amoxicillin treatment for LRTI, and if any subgroup is at increased risk of any or a specific AE...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29235986/managing-diabetes-in-people-with-dementia-a-realist-review
#13
Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone, Chris Burton
BACKGROUND: Dementia and diabetes mellitus are common long-term conditions that coexist in a large number of older people. People living with dementia and diabetes may be at increased risk of complications such as hypoglycaemic episodes because they are less able to manage their diabetes. OBJECTIVES: To identify the key features or mechanisms of programmes that aim to improve the management of diabetes in people with dementia and to identify areas needing further research...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29235940/slc9b1-methylation-predicts-fetal-intolerance-of-labor
#14
Anna K Knight, Karen N Conneely, Varun Kilaru, Dawayland Cobb, Jennifer L Payne, Samantha Meilman, Elizabeth J Corwin, Zachary A Kaminsky, Anne L Dunlop, Alicia K Smith
Fetal intolerance of labor is a common indication for delivery by Caesarean section. Diagnosis is based on the presence of category III fetal heart rate tracing, which is an abnormal heart tracing associated with increased likelihood of fetal hypoxia and metabolic acidemia. This study analyzed data from 177 unique women who, during their prenatal visits (7-15 weeks and/or 24-32 weeks) to Atlanta area prenatal care clinics, consented to provide blood samples for DNA methylation (HumanMethylation450 BeadChip) and gene expression (Human HT-12 v4 Expression BeadChip) analyses...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29235886/effect-of-induced-vertical-disparity-on-horizontal-fusional-reserves
#15
Hamed Momeni-Moghaddam, Abbas-Ali Yekta, James Kundart, Mohammad Etezad-Razavi, Farshad Askarizadeh
PURPOSE: The aim of this study was to investigate the effects of induced vertical disparity on horizontal fusional reserves at near. MATERIALS AND METHODS: In 170 healthy subjects wearing best corrective refraction, the negative and positive horizontal fusional reserves were measured with base-in (BI) and base-out (BO) prisms, respectively, in the presence of 0.5 prism diopters (∆) and 1∆ vertical prisms placed in trial frames in front of the right eye. The prism power was slowly increased step by step until the subject reported sustained blur, break, and recovery...
December 13, 2017: Strabismus
https://www.readbyqxmd.com/read/29235871/increased-levels-of-circulating-fatty-acids-are-associated-with-protective-effects-against-future-cardiovascular-events-in-non-diabetics
#16
Muhammad Anas Kamleh, Olga McLeod, Antonio Checa, Damiano Baldassarre, Fabrizio Veglia, Karl Gertow, Steve E Humphries, Rainer Rauramaa, Ulf deFaire, Andries J Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Elena Tremoli, Angela Silveira, John Orvik, Anders Hamsten, Craig E Wheelock
Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide, particularly in individuals with diabetes. The current study objective was to determine the circulating metabolite profiles associated with the risk of future cardiovascular events, with emphasis on diabetes status. Non-targeted metabolomics analysis was performed by LC-HRMS in combination with targeted quantification of eicosanoids and endocannabinoids. Plasma from 375 individuals from the IMPROVE pan-European cohort were included in a case-control study design...
December 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29235843/self-sterilizing-and-regeneratable-microchip-for-the-precise-capture-and-recovery-of-viable-circulating-tumor-cells-from-patients-with-cancer
#17
Lanlan Hui, Yi Su, Tingting Ye, Zhao Liu, Qingchang Tian, Chuanjiang He, Yueqi Zhao, Pu Chen, Xiaojia Wang, Weidong Han, Yan Luo, Ben Wang
Cancer cells metastasize and are transported in the bloodstream, easily reaching any site in the body through the blood circulation. A method designed to assess the number of circulating tumor cells (CTCs) should be validated as a clinical tool for predicting the response to therapy and monitoring disease progression in patients with cancer. Although CTCs are detectable in many cases, they remain unavailable for clinic usage due to their high testing cost, tedious operation and poor clinical relevance. Herein, we developed a regeneratable microchip for isolating CTCs that is available for robust cell heterogeneity assays on-site without the need for a sterile environment...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235686/the-missing-father-function-in-psychoanalytic-theory-and-technique-the-analyst-s-internal-couple-and-maturing-intimacy
#18
Michael J Diamond
This paper argues that recovering the "missing" paternal function in analytic space is essential for the patient's achievement of mature object relations. Emerging from the helpless infant's contact with primary caregivers, mature intimacy rests on establishing healthy triadic functioning based on an infant-with-mother-and-father. Despite a maternocentric bias in contemporary clinical theory, the emergence of triangularity and the inclusion of the paternal third as a separating element is vital in the analytic dyad...
October 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/29235684/on-becoming-able-to-play-individual-child-psychoanalytic-psychodrama-and-the-development-of-symbolization
#19
Luca Quagelli, Paola Solano
In this paper, the authors analyze the relevance and transformative potential of individual psychoanalytic psychodrama in the treatment of children with severe impairments in symbolization. Central features of this modality, including promoting the representation of early traumatic experiences, are presented and discussed. Specific features include double-envelope containment of the co-therapists' group and play leader, consequent diffraction of the transference-determining portrayal, gradual integration, and initial figuration of coexisting split-off fragments...
October 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/29235668/a-diaper-bank-and-home-visiting-partnership-initial-exploration-of-research-and-policy-questions
#20
Lois S Sadler, Eileen M Condon, Shirley Z Deng, Monica Roosa Ordway, Crista Marchesseault, Andrea Miller, Janet Stolfi Alfano, Alison M Weir
OBJECTIVES: The cost of diapering an infant can place a significant financial strain on families living in poverty. Partnerships between diaper banks and home visiting programs for young families may offer an innovative solution to expanding the reach and impact of diaper banks in low-income communities. The purpose of this pilot study was to uncover preliminary information about the functions of diaper distribution through home visiting programs, and to inform future research and policy questions regarding diaper distribution to families in need...
December 13, 2017: Public Health Nursing
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