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https://www.readbyqxmd.com/read/29933506/pharmacodynamic-analysis-of-eribulin-safety-in-breast-cancer-patients-using-real-world-post-marketing-surveillance-data
#1
Takahisa Kawamura, Hidefumi Kasai, Valentina Fermanelli, Toshiaki Takahashi, Yukinori Sakata, Toshiyuki Matsuoka, Mika Ishii, Yusuke Tanigawara
Post-marketing surveillance is useful to collect safety data in real-world clinical settings. In this study, we firstly applied the post-marketing real-world data on a mechanistic model analysis for neutropenic profiles of eribulin in patients with recurrent or metastatic breast cancer (RBC/MBC). Demographic and safety data were collected using an active surveillance method from eribulin-treated RBC/MBC patients. Changes in neutrophil counts over time were analyzed using a mechanistic pharmacodynamic model...
June 22, 2018: Cancer Science
https://www.readbyqxmd.com/read/29933494/a-life-participation-approach-to-primary-progressive-aphasia-intervention
#2
Emily J Rogalski, Becky Khayum
Primary progressive aphasia (PPA) is a clinical neurodegenerative dementia syndrome characterized by deficits in spoken and written word retrieval, word usage, and/or word comprehension. Currently, there are no effective treatments to reverse or halt the underlying disease process; however, speech-language therapy may be helpful. The Communication Bridge Care Model was developed to address the unique communication and quality of life needs of individuals living with PPA. The core elements include person-centered care with dyadic instruction for disease education, and counseling, along with tailored levels of impairment- and compensatory-based communication strategy training...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933492/group-communication-treatment-for-individuals-with-ppa-and-their-partners
#3
Aimee Mooney, Naomi Beale, Melanie Fried-Oken
Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious language deterioration. This young-onset disorder leaves adults with reduced communication skills for participation in social activities. There is limited evidence regarding group treatment for individuals with PPA, though the principles of chronic aphasia groups can be applied to this clinical population. We developed a PPA group treatment model incorporating compensatory strategies from augmentative and alternative communication (AAC), communication partner training from aphasia rehabilitation, and systematic instruction from dementia management...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933439/understanding-and-communicating-measures-of-treatment-effect-on-survival-can-we-do-better
#4
Everardo D Saad, John R Zalcberg, Julien Péron, Elisabeth Coart, Tomasz Burzykowski, Marc Buyse
Time-to-event end points are the most frequent primary end points in phase III oncology trials, both in the adjuvant and advanced settings. The evaluation of these end points is important to inform clinical practice. However, although different measures can be used to describe the effect of treatment on these end points, we believe that any treatment benefit in a given trial is best reported using various absolute and relative measures. Our goal is to help clinicians understand the strengths and limitations of the traditional and novel measures used to denote the effect of treatment in randomized trials...
March 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#5
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29933405/influence-of-cast-change-interval-in-the-ponseti-method-a-systematic-review
#6
R B Giesberts, M C van der Steen, P G M Maathuis, A T Besselaar, E E G Hekman, G J Verkerke
BACKGROUND: Clubfeet are commonly treated using the Ponseti method. This method involves weekly manipulation and casting which gradually corrects the position of the foot. However, the reasons for following a weekly interval are not clear. QUESTION / PURPOSE: The aim is to investigate the influence of the cast change interval on treatment outcomes in the Ponseti method. METHODS: We performed a systematic review of comparative studies in which the cast change interval was varied...
2018: PloS One
https://www.readbyqxmd.com/read/29933343/impact-of-a-graded-exercise-program-on-vo2peak-and-survival-in-heart-failure-patients
#7
Johan A Snoek, Thijs M H Eijsvogels, Arnoud W J van 't Hof, Eva Prescott, Maria T Hopman, Evelien Kolkman, Ed P de Kluiver
INTRODUCTION: Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. METHODS: This prospective cohort study included sixty CHF patients between 2009 and 2010...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29933309/the-effectiveness-of-the-sport-dragon-boat-racing-in-reducing-the-risk-of-lymphedema-incidence-an-observational-study
#8
Laura Iacorossi, Francesca Gambalunga, Simona Molinaro, Rosaria De Domenico, Diana Giannarelli, Alessandra Fabi
BACKGROUND: Upper extremity lymphedema is a complication that often occurs in women with breast cancer as a result of surgery and/or radiotherapy. Some studies report that a boating activity known as the "dragon boat" sport can benefit these women. AIM: The aim of this study was to assess whether this type of sport prevents or reduces lymphedema, its impact on quality of life (QoL), and the possible predictors of this condition. METHODS: This was an observational study of 2 groups: group A (women who participated in dragon boat racing for at least 6 months) and group B (women who participated in other forms of physical exercise biweekly)...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933299/preliminary-experience-with-more-stable-polidocanol-foam-in-the-sclerotherapy-of-head-and-neck-venous-malformations
#9
An-Wei Chen, Shao-Hua Liu, Ying-Ying Huang, Tao Wang
BACKGROUND: Foam sclerotherapy is an effective treatment strategy for venous malformations (VMs). Stability is one of the characteristics of sclerosant foams that determine the sclerosing power. OBJECTIVE: To evaluate the clinical outcomes of sclerotherapy with prolonged half-life of hyaluronic acid (HA)-polidocanol (POL) foam for treating head and neck VMs. MATERIALS AND METHODS: Seventy patients with head and neck VMs were enrolled between October 2013 and January 2015 in Qilu Hospital Shandong University...
June 21, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29933282/concussion-symptom-profiles-among-child-adolescent-and-young-adult-athletes
#10
David R Howell, Peter Kriz, Rebekah C Mannix, Tyler Kirchberg, Christina L Master, William P Meehan
OBJECTIVES: (1) To examine how age influences initial symptom presentation following concussion; and (2) to determine whether specific symptom profiles are associated with duration of postconcussion symptoms, and whether they vary by age group. DESIGN: A total of 689 patients (20% children 7-12 years of age, 69% adolescents 13-18 years of age, and 11% young adults 19-30 years of age) were seen and diagnosed with a concussion within 21 days after injury. Patients completed the Post-Concussion Symptom Scale (PCSS) and were followed until they no longer required care...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29933267/perioperative-management-in-hepatic-resections-comparative-effectiveness-of-neuraxial-anesthesia-and-disparity-of-care-patterns
#11
Jeron Zerillo, Parul Agarwal, Jashvant Poeran, Nicole Zubizarreta, George Poultsides, Myron Schwartz, Stavros Memtsoudis, Madhu Mazumdar, Samuel DeMaria
BACKGROUND: Complication rates after hepatic resection can be affected by management decisions of the hospital care team and/or disparities in care. This is true in many other surgical populations, but little study has been done regarding patients undergoing hepatectomy. METHODS: Data from the claims-based national Premier Perspective database were used for 2006 to 2014. The analytical sample consisted of adults undergoing partial hepatectomy and total hepatic lobectomy with anesthesia care consisting of general anesthesia (GA) only or neuraxial and GA (n = 9442)...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933258/a-cross-sectional-questionnaire-study-of-tinnitus-awareness-and-impact-in-a-population-of-adult-cochlear-implant-users
#12
Philip A Gomersall, David M Baguley, Robert P Carlyon
OBJECTIVES: The primary aim was to identify the proportion of individuals within the adult cochlear implant population who are aware of tinnitus and those who report a negative impact from this perception, using a bespoke questionnaire designed to limit bias. A secondary aim was to use qualitative analysis of open-text responses to identify themes linked to tinnitus perception in this population. DESIGN: A cross-sectional questionnaire study of a large clinical population who received an implant from Cambridge University Hospitals, United Kingdom...
June 21, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29933242/impact-of-strut-dimensions-and-vessel-caliber-on-thrombosis-risk-of-bioresorbable-scaffolds-using-hemodynamic-metrics
#13
Michael Stiehm, Carolin Wüstenhagen, Stefan Siewert, Hüseyin Ince, Niels Grabow, Klaus-Peter Schmitz
Bioresorbable scaffolds (BRS) promise to be the treatment of choice for stenosed coronary vessels. But higher thrombosis risk found in current clinical studies limits the expectations. Three hemodynamic metrics are introduced to evaluate the thrombosis risk of coronary stents/scaffolds using transient computational fluid dynamics (CFD). The principal phenomena are platelet activation and effective diffusion (platelet shear number, PSN), convective platelet transport (platelet convection number, PCN) and platelet aggregation (platelet aggregation number, PAN) were taken into consideration...
June 22, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29933232/evaluation-of-biological-response-induced-by-molybdenum-oxide-nanocolloids-on-in-vitro-cultured-nih-3t3-fibroblast-cells-by-micro-raman-spectroscopy
#14
Enza Fazio, Antonio Speciale, Salvatore Spadaro, Martina Bonsignore, Francesco Cimino, Mariateresa Cristani, Domenico Trombetta, Antonella Saija, Fortunato Neri
Tailored colloids of uniformly sized and engineered molybdenum oxide nanoparticles were produced, for the first time, by pulsed laser ablation in water. This green technique ensures the formation of contaminant-free nanostructures and the absence of by-products, very useful issues in biological applications. A selective tuning of MoO chemical bonding configurations and a suitable control of nanoparticles size distributions were achieved during the ablation processes by varying the water temperature and by applying an external electric field...
June 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29933207/multi-targeting-effects-of-a-new-synthetic-molecule-jm-20-in-experimental-models-of-cerebral-ischemia
#15
REVIEW
Yanier Nuñez-Figueredo, Jeney Ramírez-Sánchez, Gilberto L Pardo Andreu, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O Souza
Ischemic stroke is a major cause of death and disability worldwide. Thrombolysis by tissue plasminogen activator is the only pharmacological treatment approved for clinical practice, but has a narrow therapeutic window and poor efficacy when the cell death cascade is activated. Numerous drugs that are thought to protect neurons against injury have previously failed in human trials despite showing efficacy in experimental models of stroke. Herein, we reviewed the main pre-clinical results of the neuroprotective effects of JM-20, a new hybrid molecule, against brain ischemia...
February 12, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933206/the-pattern-of-pharmacological-treatment-of-bipolar-patients-discharged-from-psychiatric-units-in-poland
#16
Jan Jaracz, Edyta Tetera- Rudnicka, Magdalena Bierejszyk, Kaja Witczyk, Agnieszka Raczyńska, Wojciech Nowak, Anna Pisarczyk, Krzysztof Woźniak, Wojciech Czernaś, Adam Moniakowski, Krystyna Jaracz
BACKGROUND: The concomitant use of two or more mood stabilisers (MS), second-generation antipsychotics (SGA), lamotrigine as well as antidepressants, is frequently reported in the treatment of bipolar patients The aim of this study was to investigate the pattern of pharmacological treatment with special regard to polypharmacy defined as two or more psychiatric drugs taken at the same time in the same patients with bipolar disorder discharged from psychiatric units in Poland. METHOD: Pharmacotherapy of 127 consecutive patients (57 females and 70 males) with an ICD-10 diagnosis of bipolar disorder (BP) at the point of discharge from five psychiatric regional hospitals/units in Poland, was evaluated in 2015/2016 on the basis of medical files...
February 5, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933183/quantification-of-multi-segment-trunk-kinetics-during-multi-directional-trunk-bending
#17
Alireza Noamani, Albert H Vette, Richard Preuss, Milos R Popovic, Hossein Rouhani
BACKGROUND: Motion assessment of the body's head-arms-trunk (HAT) using linked-segment models, along with an inverse dynamics approach, can enable in vivo estimations of inter-vertebral moments. However, this mathematical approach is prone to experimental errors because of inaccuracies in (i) kinematic measurements associated with soft tissue artifacts and (ii) estimating individual-specific body segment parameters (BSPs). The inaccuracy of the BSPs is particularly challenging for the multi-segment HAT due to high inter-participant variability in the HAT's BSPs and no study currently exists that can provide a less erroneous estimation of the joint moments along the spinal column...
June 18, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29933147/i-care-randomized-clinical-trial-integrating-depression-and-acute-coronary-syndrome-care-in-low-resource-hospitals-in-china-design-and-rationale
#18
Shenshen Li, James A Blumenthal, Chuan Shi, Danielle Millican, Xian Li, Xin Du, Anushka Patel, Pei Gao, Elizabeth Delong, Pallab K Maulik, Runlin Gao, Xin Yu, Yangfeng Wu
Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrate depression care into the management of ACS patients to reduce depression and improve ACS outcomes are critically needed. Integrating Depression Care in ACS patients in Low Resource Hospitals in China (I-CARE) is a multicenter, randomized controlled trial to evaluate the efficacy of an 11-month integrated care (IC) intervention compared to usual care (UC) in management of ACS patients...
May 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29933123/the-effect-of-upper-instrumented-vertebra-level-on-cervical-sagittal-alignment-in-lenke-1-adolescent-idiopathic-scoliosis
#19
Ismail Emre Ketenci, Hakan Serhat Yanik, Sevki Erdem
BACKGROUND: This study aimed to evaluate the relationship between upper instrumented vertebra (UIV) level and cervical sagittal alignment (CSA) in Lenke 1 adolescent idiopathic scoliosis (AIS) patients, treated with posterior instrumentation. The hypothesis was that higher level of UIV would cause decreased cervical lordosis. METHODS: 63 Lenke 1 AIS patients that underwent posterior fusion with pedicle screw instrumentation were retrospectively evaluated. Patients were divided into three groups according to UIV level (T2, T3, T4)...
June 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29933105/stable-cellular-models-of-nuclear-receptor-pxr-for-high-throughput-evaluation-of-small-molecules
#20
Seema Negi, Shashi Kala Singh, Sanjay Kumar, Subodh Kumar, Rakesh K Tyagi
Pregnane & Xenobiotic Receptor (PXR) is one of the 48 members of the ligand-modulated transcription factors belonging to nuclear receptor superfamily. Though PXR is now well-established as a 'xenosensor', regulating the central detoxification and drug metabolizing machinery, it has also emerged as a key player in several metabolic disorders. This makes PXR attractive to both, researchers and pharmaceutical industry since clinical success of small drug molecules can be pre-evaluated on PXR platform. At the early stages of drug discovery, cell-based assays are used for high-throughput screening of small molecules...
June 19, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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