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https://www.readbyqxmd.com/read/29225061/crowdsourcing-disease-biomarker-discovery-research-the-ip4ic-study
#1
Michael B Chancellor, Sarah N Bartolone, Andrew Veerecke, Laura E Lamb
PURPOSE: Biomarker discovery is limited by readily assessable, cost efficient, human samples available in large numbers that represent the entire heterogeneity of the disease. We developed a novel active participation crowdsourcing method to develop a Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines to discriminate Interstitial cystitis/bladder pain syndrome (IC/BPS) with Hunner's lesion (UIC) patients from controls and IC patients without Hunner's lesions...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29224700/preventing-weakness-and-stiffness-a-top-priority-for-health-and-social-care
#2
REVIEW
Muir Gray, Kenny Butler
With growing evidence that sarcopenia, disability and frailty can be prevented with physical activity, people living with pain, stiffness and weakness due to a musculoskeletal condition should be offered physical activity as a preventive strategy. By changing beliefs and attitudes towards ageing and raising the value and importance of physical activity, disability can be avoided or delayed and the costly burden of social care lessened. The effects of ageing and the effects of muscle strength loss are often confused...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29222890/home-enteral-nutrition-after-minimally-invasive-esophagectomy-can-improve-quality-of-life-and-reduce-the-risk-of-malnutrition
#3
Zixiang Wu, Ming Wu, Qi Wang, Tianwei Zhan, Lian Wang, Saibo Pan, Gang Chen
BACKGROUND AND OBJECTIVES: The potential benefits of home enteral nutrition (HEN) and the effects of HEN on quality of life (QOL) after esophagectomy remain unclear. The aim was to investigate the effect of 3 months HEN on health related QOL and nutritional status of esophageal cancer patients who were preoperatively malnourished. METHODS AND STUDY DESIGN: 142 malnourished (PG-SGA stage B or C) patients with esophageal cancer were assigned to receive Ivor Lewis minimally invasive esophagectomy (MIE group) with laparoscopic jejunal feeding tube placement or open esophagectomy (OE group) with nasojejunal feeding tube placement...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222303/responsiveness-of-patient-reported-outcome-measurement-information-system-promis-pain-domains-and-disease-specific-patient-reported-outcome-measures-in-children-and-adults-with-sickle-cell-disease
#4
REVIEW
Susanna Curtis, Amanda M Brandow
Case 1: A 33-year-old man with hemoglobin SS (homozygous hemoglobin S) disease presents for his regular clinic visit. He had 6 hospital admissions for pain over the past year. He also has avascular necrosis of the right hip. He takes daily hydroxyurea with hematologic changes indicative of compliance. He also takes morphine sustained release twice daily and morphine immediate release every 6 hours as needed for pain. He feels that more optimal pain control at home would help him reduce his number of hospital admissions in the upcoming year and improve his daily functioning at home...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222301/optimizing-the-care-model-for-an-uncomplicated-acute-pain-episode-in-sickle-cell-disease
#5
REVIEW
Paul Telfer, Banu Kaya
The pathophysiology, clinical presentation, and natural history of acute pain in sickle cell disease are unique and require a disease-centered approach that also applies general principles of acute and chronic pain management. The majority of acute pain episodes are managed at home without the need to access health care. The long-term consequences of poorly treated acute pain include chronic pain, adverse effects of chronic opioid usage, psychological maladjustment, poor quality of life, and excessive health care utilization...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222222/inguinoscrotal-herniation-of-a-caecal-adenocarcinoma
#6
Sachin Krishan Sharma
An 84-year-old man with multiple comorbidities presented from a residential care home with a 1-month history of asthenia and moderate abdominal pain. On examination, he was found to have an irreducible right-sided inguinoscrotal hernia. Subsequent blood tests revealed a significant anaemia (haemoglobin 48 g/L), for which he was transfused. A CT scan of the abdomen and pelvis revealed a large caecal tumour, herniating through the right inguinal canal into the scrotum. The patient underwent an elective open right hemicolectomy with inguinal hernia defect repair, from which he recovered well...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221471/in-home-versus-hospital-preoperative-balance-and-proprioceptive-training-in-patients-undergoing-tkr-rationale-design-and-method-of-a-randomized-controlled-trial
#7
José-María Blasco, Celedonia Igual-Camacho, Sergio Roig-Casasús
BACKGROUND: Severe knee osteoarthritis, as well as the surgical procedure of total knee replacement that aims to reduce its symptoms, cause great deterioration on the proprioceptive system. Taking this fact into account, and considering that balance abilities positively influence the capacity to perform basic functional tasks, this trial aims to find the short and mid-term effects of a preoperative balance and proprioceptive training when conducted by patients undergoing total knee replacement...
December 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29221336/hemangiopericytoma-11-years-later-delayed-recurrence-of-a-rare-soft-tissue-sarcoma
#8
Keng Peng Cheng, Wei-Jin Wong, Shahrul Hashim, Kein Seong Mun
Hemangiopericytomas (HPCs) are uncommon tumours. We present the case of a 41-year-old female with multiple resections at different sites over the course of 11 years. The approach considerations, as well as treatment options and prognosis are discussed. A 41-year-old female with two previous resections for intracranial meningeal HPC in 2004 and 2008, as well as adjuvant radiotherapy, presented in 2015 with left intrathoracic and left hip recurrence confirmed by positron emission tomography/computed tomography (PET/CT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218932/-research-progress-of-bixie
#9
REVIEW
Chong Chen, Chen-Hong Zeng, Si-Qi Zhang, Li Wei
The Dioscorea hypoglauca rhizome and D. spongiosa rhizome in "China Pharmacopoeia" are often used as Bixie in clinically, with the function of removing dampness, clearing away turbidness and dispelling wind to remove pain, and has been widely used in stranguria marked by chyluria, joint stiffness and rheumatic arthralgia. It has obvious curative effect and broad application prospect. However, in recent years the progress of research is slow for its miscellaneous sources, chaotic varieties and lack of relevant quality assessment...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218448/how-does-spa-treatment-affect-cardiovascular-function-and-vascular-endothelium-in-patients-with-generalized-osteoarthritis-a-pilot-study-through-plasma-asymmetric-di-methyl-arginine-adma-and-l-arginine-adma-ratio
#10
Fatih Karaarslan, Kagan Ozkuk, Serap Seringec Karabulut, Seldag Bekpinar, Mufit Zeki Karagulle, Nergis Erdogan
The study aims to investigate the effect of spa treatment on vascular endothelium and clinical symptoms of generalized osteoarthritis. Forty generalized osteoarthritis (GOA) patients referred to a government spa hospital, and 40 GOA patients followed on university hospital locomotor system disease ambulatory clinics were included as study and control groups, respectively. Study group received spa treatment including thermal water baths, physical therapy modalities, and exercises. Control group was followed with home exercises for 15 days...
December 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29217178/factors-associated-with-advanced-cardiac-care-in-prehospital-chest-pain-patients
#11
Adam Frisch, Kenneth J Heidle, Stephanie O Frisch, Ashar Ata, Brandon Kramer, Caroline Colleran, Jestin N Carlson
INTRODUCTION: Many patients transported by emergency medical services (EMS) may require advanced cardiac care but do not have ST-segment elevation (STEMI) on the initial prehospital EKG. We sought to identify factors associated with the need for advanced cardiac care in undifferentiated EMS patients reporting chest pain in the absence of STEMI on EKG. METHODS: We performed a retrospective analysis of all adult patients, reporting atraumatic chest pain from a single EMS agency, presenting to a single, urban hospital over a 10-year period...
December 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29216831/validity-of-mobile-electronic-data-capture-in-clinical-studies-a-pilot-study-in-a-pediatric-population
#12
Belinda von Niederhäusern, Ramon Saccilotto, Sabine Schädelin, Victoria Ziesenitz, Pascal Benkert, Marie-Luise Decker, Anya Hammann, Julia Bielicki, Marc Pfister, Christiane Pauli-Magnus
BACKGROUND: Clinical studies in children are necessary yet conducting multiple visits at study centers remains challenging. The success of "care-at-home" initiatives and remote clinical trials suggests their potential to facilitate conduct of pediatric studies. This pilot aimed to study the feasibility of remotely collecting valid (i.e. complete and correct) saliva samples and clinical data utilizing mobile technology. METHODS: Single-center, prospective pilot study in children undergoing elective tonsillectomy at the University of Basel Children's Hospital...
December 8, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29216008/adherence-to-growth-hormone-therapy-in-children-and-its-potential-barriers
#13
Shahrzad Mohseni, Zahra Heydari, Mostafa Qorbani, Mania Radfar
BACKGROUND: One of the main concerns in chronic diseases such as growth hormone (GH) deficiency is adherence to the treatment, which significantly affects treatment outcomes. METHODS: This cross-sectional study was conducted among 169 GH recipient children (2-12 years) and teens (13-19 years) referred to a GH distributing teaching pharmacy. The eight-item Morisky Medication Adherence Scale (MMAS) and auto-compliance method were used for the assessment of patients' adherence to GH...
December 7, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29215954/evolution-of-various-components-of-pain-after-laparoscopic-cholecystectomy-importance-of-its-prognostication-for-effective-pain-control-using-a-local-anesthetic-and-for-making-a-valid-practical-discharge-criteria-model-predicting-early-discharge-of-patients
#14
Singh Mathuria Kaushal-Deep, Mehershree Lodhi, Afzal Anees, Shehtaj Khan, Mohammad Amanullah Khan
OBJECTIVES: Pain continues to be the most important limiting factor affecting the early discharge of patients after laparoscopic cholecystectomy (LC). Our aim was to conduct a randomized case controlled study to predict the evolution of various components of postoperative pain by using ropivacaine 0.2% at intraperitoneal and intraincisional locations; and to further use this information to make a model predicting early discharge of patients. METHODS: Two hundred forty-four patients underwent elective four-port LC...
December 7, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29212683/-hot-joints-infection-protocol-reduces-unnecessary-post-operative-re-admissions-following-total-hip-and-knee-arthroplasty
#15
J Dattilo, D Gittings, M Sloan, R Charette, E Hume, G-C Lee
AIMS: To evaluate the effectiveness of an institutionally developed algorithm for evaluation and diagnosis of prosthetic joint injection and to determine the impact of this protocol on overall hospital re-admissions.p PATIENTS AND METHODS: We retrospectively evaluated 2685 total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients prior to (1263) and following (1422) the introduction of an infection detection protocol. The protocol used conservative thresholds for C-reactive protein to direct the medical attendant to aspirate the joint...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29211583/end-of-life-care-in-nursing-homes-a-qualitative-interpretive-meta-synthesis
#16
Cara L Wallace, Gail Adorno, Daniel B Stewart
BACKGROUND: Due to large number of deaths occurring in nursing home (NH) settings, along with reports of pain and suffering, there is great need for improvements in the provision of end-of-life (EOL) care in NHs. OBJECTIVE: The aim of this study was to develop a comprehensive understanding of the experience of dying in NHs through the perspective of residents, family, and facility staff. DESIGN: This study uses a qualitative interpretive meta-synthesis to provide a holistic view of EOL care in NHs across multiple qualitative studies...
December 6, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29211234/comparison-of-the-cognitive-performance-of-elderly-caregivers-with-and-without-chronic-pain
#17
Marielli Terassi, Estefani Serafim Rossetti, Karina Gramani-Say, Tiago da Silva Alexandre, Priscilla Hortense, Sofia Cristina Iost Pavarini
OBJECTIVE Understanding and characterizing chronic pain in elderly caregivers, verifying the cognitive performance of the elderly of the sample and verifying whether there is difference in the cognitive performance of elderly caregivers with and without chronic pain. METHOD Participants were people aged 60 years or older who lived with another elderly person in the same household and who were registered in Family Health Units. Data collection took place at participants' homes. Pain was assessed by the EMADOR and cognition was assessed by ACE-R...
2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29209545/difficult-to-treat-focal-stiff-person-syndrome-of-the-left-upper-extremity
#18
Nathan E Esplin, John W Stelzer, Timothy B Legare, Sayed K Ali
Background: Stiff person syndrome (SPS) is a rare neurologic disorder characterized by muscle rigidity. It is a disorder of reduced GABA activity leading to increased muscle tone and often painful spasms. It generally presents in the axial musculature but rarely can involve only one limb, typically a lower extremity. In rare cases it can be paraneoplastic which generally resolves on treatment of the underlying neoplasm. Case Report: A 46-year-old male with a history of Hodgkin's Lymphoma in remission presented with left upper extremity pain secondary to a diagnosis of Stiff Person Syndrome limited to his left upper extremity...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29208727/an-unusual-case-of-abdominal-pain-and-hyponatremia-in-a-16-year-old-girl-with-disordered-eating
#19
Grace Hunter, Rebecca Blankenburg, Jennifer Andrews, Terrell Stevenson
A previously healthy 16-year-old girl presented to the emergency department with 1 week of severe, diffuse abdominal pain and constipation, as well as several episodes of nonbloody, nonbilious emesis. Her symptoms began several days after she decreased her caloric intake in an attempt to lose weight. She had been drinking 48 to 60 oz of water per day for several days before admission in an attempt to ameliorate her constipation. She also admits to drinking alcohol the night before her pain began. She had visited several other emergency departments before her presentation to our hospital, and she had been sent home on a bowel regimen without amelioration of her symptoms...
December 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/29207021/stromal-cell%C3%A2-derived-factor%C3%A2-1-induces-matrix-metalloproteinase-expression-in-human-endplate-chondrocytes-cartilage-endplate-degradation-in-explant-culture-and-the-amelioration-of-nucleus-pulposus-degeneration-in-vivo
#20
Hua Zhang, Ting Zhu, Li Zhang, Qionghua Wu
Intervertebral disc (IVD) degeneration is a strong etiological factor in chronic lower back pain. Stem cell migration toward the site of IVD degeneration for regeneration is restricted by avascularity and distance. Our previous study indicated that the expression of stromal cell‑derived factor‑1 (SDF‑1) and its receptor, C-X-C chemokine receptor type 4 (CXCR4) was upregulated in degenerated cartilage endplate (CEP) and nucleus pulposus (NP). In the present study, SDF‑1 increased CXCR4 mRNA and protein expression in human endplate chondrocytes in a dose‑dependent manner...
November 22, 2017: International Journal of Molecular Medicine
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