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body plethysmography

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https://www.readbyqxmd.com/read/28077140/indacaterol-and-glycopyrronium-versus-indacaterol-on-body-plethysmography-measurements-in-copd-a-randomised-controlled-study
#1
Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens, Martin Brutsche
BACKGROUND: Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. METHODS: This multicentre, randomised, double-blind, single-dose, cross-over, placebo-controlled study evaluated efficacy and safety of the free combination of indacaterol maleate (IND) and glycopyrronium bromide (GLY) versus IND alone on spirometric and body plethysmography parameters, including inspiratory capacity (IC), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC) and airway resistance (Raw) in moderate-to-severe COPD patients...
January 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28067630/novel-swine-model-of-ricin-induced-acute-respiratory-distress-syndrome
#2
Shahaf Katalan, Reut Falach, Amir Rosner, Michael Goldvaser, Tal Brosh-Nissimov, Ayana Dvir, Avi Mizrachi, Orr Goren, Barak Cohen, Yoav Gal, Anita Sapoznikov, Sharon Ehrlich, Tamar Sabo, Chanoch Kronman
Pulmonary exposure to the plant toxin ricin, leads to respiratory insufficiency and death. To date, in-depth study of the functional disorders ensuing pulmonary intoxication, a prerequisite for establishing a clinically-relevant therapeutic protocol, is hampered by the lack of an appropriate animal model. To this end, we set up the pig, as a large animal model for the comprehensive study of the multifarious clinical manifestations of pulmonary ricinosis.Here we report for the first time, the monitoring of barometric whole body plethysmography for pulmonary function tests in non-anesthetized ricin-intoxicated pigs...
January 6, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28056907/lung-function-in-very-low-birth-weight-infants-after-pharmacological-and-surgical-treatment-of-patent-ductus-arteriosus-a-retrospective-analysis
#3
Payman Barikbin, Hannes Sallmon, Silke Wilitzki, Joachim Photiadis, Christoph Bührer, Petra Koehne, Gerd Schmalisch
BACKGROUND: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after successful PDA treatment with a cyclooxygenase inhibitor or secondary surgical ligation. METHODS: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA), were examined at a median postmenstrual age of 48 weeks...
January 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28056550/co-inhalation-of-roflumilast-rather-than-formoterol-with-fluticasone-more-effectively-improves-asthma-in-asthmatic-mice
#4
Hussam A Murad, Hamed S Habib, Misbahuddin M Rafeeq, Mansour I Sulaiman, Amer S Abdulrahman, Mohamad Nidal Khabaz
Roflumilast is approved as an add-on therapy for chronic obstructive pulmonary disease. The inflammation in chronic obstructive pulmonary disease is mainly neutrophilic, while in asthma it is mainly eosinophilic, studies addressing role of roflumilast in eosinophilic inflammation are recommended. Also in severe asthma, the dominant inflammatory cells are neutrophils. Thus, roflumilast has a potential off-label use in the treatment of asthma. This study was designed to evaluate the effects of co-inhalation of roflumilast and fluticasone compared to that of formoterol and fluticasone in ovalbumin-sensitized and-challenged BALB/c mice...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28054389/health-effects-of-laser-printer-emissions-a-controlled-exposure-study
#5
Stefan Karrasch, Myriam Simon, Britta Herbig, Jeanette Langner, Stefan Seeger, Angelika Kronseder, Stefan Peters, Gisela Dietrich-Gümperlein, Rudolf Schierl, Dennis Nowak, Rudolf A Jörres
Ultrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross-over manner in 23 healthy subjects, 14 mild, stable asthmatics and 15 persons reporting symptoms associated with LPD emissions. Low level exposures (LLE) ranged at the particle background (3,000 cm(-3) ), high level exposures (HLE) at 100,000 cm(-3) . Examinations before and after exposures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE...
January 5, 2017: Indoor Air
https://www.readbyqxmd.com/read/28045768/body-composition-trajectories-from-infancy-to-preschool-in-children-born-premature-versus-full-term
#6
Johannah M Scheurer, Lei Zhang, Heather L Gray, Katherine Weir, Ellen W Demerath, Sara E Ramel
OBJECTIVES: The aim of the study was to longitudinally characterize infancy to preschool body composition trajectories and the association of early fat and fat-free mass gains with preschool age body composition in children born premature versus full-term. METHODS: A cohort of appropriate-for-gestational age preterm (n = 20) and term (n = 51) infants were followed at 3 visits: "neonatal" visit 1 at 2 weeks of age for term and near term corrected age for preterm; "infancy" visit 2 at 3 to 4 months (preterm corrected age); "preschool" visit 3 at 4 years...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28036119/impact-of-physical-activity-on-cardiovascular-status-in-obesity
#7
Lars Lin, Axel C Carlsson, Agneta Siegbahn, Johan Sundström, Johan Ärnlöv
BACKGROUND: We have recently shown that being physically active (PA) counteracts, but not eliminates the increased risk of future cardiovascular disease in over-weight and obese subjects. To investigate this further, we studied the impact of being normal weight, overweight and obese on multiple markers of subclinical cardiovascular disease in relation to physical activity. MATERIALS AND METHODS: At age 70, 1016 subjects were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28028619/effects-of-protein-carbohydrate-supplementation-on-immunity-and-resistance-training-outcomes-a-double-blind-randomized-controlled-clinical-trial
#8
Fernando Naclerio, Eneko Larumbe-Zabala, Nadia Ashrafi, Marco Seijo, Birthe Nielsen, Judith Allgrove, Conrad P Earnest
PURPOSE: To examine the impact of ingesting hydrolyzed beef protein, whey protein, and carbohydrate on resistance training outcomes, body composition, muscle thickness, blood indices of health and salivary human neutrophil peptides (HNP1-3), as reference of humoral immunity followed an 8-week resistance training program in college athletes. METHODS: Twenty-seven recreationally physically active males and females (n = 9 per treatment) were randomly assigned to one of the three groups: hydrolyzed beef protein, whey protein, or non-protein isoenergetic carbohydrate...
December 27, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28004642/linearity-of-electrical-impedance-tomography-during-maximum-effort-breathing-and-forced-expiration-maneuvers
#9
Chuong Ngo, Steffen Leonhardt, Tony Zhang, Markus Lüken, Berno Misgeld, Thomas Vollmer, Klaus Tenbrock, Sylvia Lehmann
Electrical impedance tomography (EIT) provides global and regional information about ventilation by means of relative changes in electrical impedance measured with electrodes placed around the thorax. In combination with lung function tests, e.g. spirometry and body plethysmography, regional information about lung ventilation can be achieved. Impedance changes strictly correlate with lung volume during tidal breathing and mechanical ventilation. Initial studies presumed a correlation also during forced expiration maneuvers...
January 2017: Physiological Measurement
https://www.readbyqxmd.com/read/27994602/vasodilation-and-exercise-capacity-in-patients-with-end-stage-renal-disease-a-prospective-proof-of-concept-study
#10
Dirk Habedank, Joerg C Schefold, Carolin Bernhardt, Tim Karhausen, Wolfram Doehner, Stefan D Anker, Petra Reinke
BACKGROUND: Previous data have pointed to the fact that vascular function is significantly impaired in patients with end-stage renal disease (ESRD). We aimed to better characterise vasodilation and exercise capacity in both ESRD and chronic heart failure (CHF) patients. METHODS: A total of 30 ESRD patients (23 male; mean age 45.7 ± 9.9 years) were included in a prospective proof-of-concept study at a tertiary care academic centre. The patients underwent forearm venous plethysmography with post-ischaemic peak blood flow (PF) and flow-dependent flow (FDF) testing as well as cardiopulmonary exercise testing during the morning of the day following the last haemodialysis...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27993527/use-of-electric-field-sensors-for-recording-respiration-heart-rate-and-stereotyped-motor-behaviors-in-the-rodent-home-cage
#11
Donald J Noble, Camden J MacDowell, Michael L McKinnon, Tamra I Neblett, William N Goolsby, Shawn Hochman
BACKGROUND: Numerous environmental and genetic factors can contribute significantly to behavioral and cardiorespiratory variability observed experimentally. Affordable technologies that allow for noninvasive home cage capture of physio-behavioral variables should enhance understanding of inter-animal variability including after experimental interventions. NEW METHOD: We assessed whether EPIC electric field sensors (Plessey Semiconductors) embedded within or attached externally to a rodent's home cage could accurately record respiration, heart rate, and motor behaviors...
December 16, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27940287/fast-onset-of-action-of-glycopyrronium-compared-with-tiotropium-in-patients-with-moderate-to-severe-copd-a-randomised-multicentre-crossover-trial
#12
Henrik Watz, Claudia Mailänder, Christoph May, Monika Baier, Anne-Marie Kirsten
BACKGROUND: Long-acting bronchodilators, including anticholinergics glycopyrronium and tiotropium, are central to symptomatic management of chronic obstructive pulmonary disease (COPD). In patients with moderate to severe COPD, glycopyrronium has demonstrated comparable efficacy to open-label and single-blinded tiotropium, but with faster onset of bronchodilation. The FAST study assessed the efficacy of glycopyrronium compared with tiotropium in serial spirometry and body plethysmography assessments to further characterize the earlier onset of action associated with glycopyrronium...
December 8, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27933755/maternal-pre-pregnancy-bmi-downregulates-neonatal-cord-blood-lep-methylation
#13
R Kadakia, Y Zheng, Z Zhang, W Zhang, L Hou, J L Josefson
BACKGROUND: Neonatal adiposity has many determinants and may be a risk factor for future obesity. Epigenetic regulation of metabolically important genes is a potential contributor. OBJECTIVES: The objective of the study is to determine whether methylation changes in the LEP gene in cord blood DNA are impacted by the maternal environment or affect neonatal adiposity measures. METHODS: A cross-sectional study of 114 full-term neonates born to healthy mothers with normal glucose tolerance was performed...
December 8, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27932874/bronchodilator-response-of-advanced-lung-function-parameters-depending-on-copd-severity
#14
Linnea Jarenbäck, Göran Eriksson, Stefan Peterson, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson
BACKGROUND: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. PURPOSE: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. PATIENTS AND METHODS: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27916086/-recombinant-adenovirus-type-5-does-not-aggravate-asthma-symptoms-in-a-mouse-model-of-ovalbumin-induced-asthma
#15
Zhengling Zhang, Yiling Zhang, Jing Han, Ping Lu, Lin Xu
Objective To explore the effect of recombinant adenovirus type 5 (rAd5) on a mouse model of ovalbumin (OVA)-induced asthma. Methods Sixty female C57BL/6 mice (6-8 weeks old and 18-20 g) were randomly divided into 4 groups: healthy control group, rAd5 control group, OVA asthma control group and OVA asthma group with rAd5 immunization. 15 mice in each group. The mice in the OVA asthma control group and the OVA asthma group with rAd5 immunization were sensitized by intraperitoneal injection of 50 μg OVA emulsified in 2 mg of aluminum potassium sulfate on day 0, 7 and 14; subsequently, the mice in the two groups were exposed to OVA aerosol challenge for 3 consecutive days (on day 42, 43 and 44)...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27890490/fragmentation-of-daily-rhythms-associates-with-obesity-and-cardiorespiratory-fitness-in-adolescents-the-helena-study
#16
Marta Garaulet, Antonio Martinez-Nicolas, Jonatan R Ruiz, Kenn Konstabel, Idoia Labayen, Marcela González-Gross, Ascensión Marcos, Dénes Molnar, Kurt Widhalm, Jose Antonio Casajús, Stefaan De Henauw, Anthony Kafatos, Christina Breidenassel, Michael Sjöström, Manuel J Castillo, Luis A Moreno, Juan A Madrid, Francisco B Ortega
BACKGROUND & AIMS: Chronobiology studies periodic changes in living organisms and it has been proposed as a promising approach to investigate obesity. We analyze the association of the characteristics of the rest-activity rhythms with obesity, cardiorespiratory fitness and metabolic risk in adolescents from nine European countries. METHODS: 1044 adolescents (12.5-17.5 y) were studied. Circadian health was evaluated by actigraphy with accelerometers (Actigraph GT1M)...
November 5, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27876834/the-measurement-of-lung-volumes-using-body-plethysmography-and-helium-dilution-methods-in-copd-patients-a-correlation-and-diagnosis-analysis
#17
Yongjiang Tang, Mingke Zhang, Yulin Feng, Binmiao Liang
Chronic obstructive pulmonary disease (COPD) is a chronic airway disease characterized by persistent airflow limitation. Moreover, lung hyperinflation evaluated by lung volumes is also the key pathophysiologic process during COPD progression. Nevertheless, there is still no preferred method to evaluate lung volumes. For this study, we recruited 170 patients with stable COPD to assess lung volumes stratified by airflow limitation severity. Lung volumes including residual volume (RV) and total lung capacity (TLC) were determined by both body plethysmography and helium dilution methods...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876761/early-infant-adipose-deposition-is-positively-associated-with-the-n-6-to-n-3-fatty-acid-ratio-in-human-milk-independent-of-maternal-bmi
#18
M C Rudolph, B E Young, D J Lemas, C E Palmer, T L Hernandez, L A Barbour, J E Friedman, N F Krebs, P S MacLean
BACKGROUND/OBJECTIVES: Excessive infant weight gain in the first 6-month of life is a powerful predictor of childhood obesity and related health risks. In mice, omega-6 fatty acids (FAs) serve as potent ligands driving adipogenesis during early development. The ratio of omega-6 relative to omega-3 (n-6/n-3) FA in human milk (HM) has increased threefold over the last 30 years, but the impact of this shift on infant adipose development remains undetermined. This study investigated how maternal obesity and maternal dietary FA (as reflected in maternal red blood cells (RBCs) composition) influenced HM n-6 and n-3 FAs, and whether the HM n-6/n-3 ratio was associated with changes in infant adipose deposition between 2 weeks and 4 months postpartum...
December 13, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27870822/comparison-of-total-lung-capacity-determined-by-plethysmography-with-computed-tomographic-segmentation-using-caliper
#19
Andrew J Matsumoto, Brian J Bartholmai, Mark E Wylam
PURPOSE: Traditionally, determination of total lung capacity (TLC) by plethysmography (TLCpleth) has been important in the diagnosis of lung diseases. Alternatively, data acquired from computerized tomography (CT) can be utilized to calculate a measure of TLC (TLCCT). The clinical utility of TLCCT is not certain. We sought to determine, in a clinical setting, whether TLCCT correlates with TLCpleth across a range of lung diseases and scanning techniques. In addition, we determined whether TLCCT affects the interpretation of pulmonary function tests...
November 18, 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27861919/consequences-of-maternal-omega-3-polyunsaturated-fatty-acid-supplementation-on-respiratory-function-in-rat-pups
#20
Luana Tenorio-Lopes, Cécile Baldy, Alexandra Jochmans-Lemoine, Océane Mercier, Olivier Pothier-Piccinin, Tommy Seaborn, Vincent Joseph, Isabelle Marc, Richard Kinkead
KEY POINTS: Incomplete development of the neural circuits that control breathing contributes to respiratory disorders in pre-term infants. Manifestations include respiratory instability, prolonged apnoeas and poor ventilatory responses to stimuli. Based on evidence suggesting that omega-3 polyunsaturated fatty acids (n-3 PUFA) improves brain development, we determined whether n-3 PUFA supplementation (via the maternal diet) improves respiratory function in 10-11-day-old rat pups. n-3 PUFA treatment prolonged apnoea duration but augmented the relative pulmonary surface area and the ventilatory response to hypoxia...
November 11, 2016: Journal of Physiology
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