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https://www.readbyqxmd.com/read/28959443/effects-of-combination-therapy-indacaterol-glycopyrronium-versus-tiotropium-on-moderate-to-severe-copd-evaluation-of-impulse-oscillometry-and-exacerbation-rate
#1
Antonio Molino, Francesca Simioli, Anna Agnese Stanziola, Mauro Mormile, Maria Martino, Maria D'Amato
BACKGROUND: Small airways are considered the major site of airflow limitation in COPD. Impulse oscillometry (IOS) is a forced oscillation technique, which provides passive measurement of lung mechanics. It can differentiate small airway from large airway obstruction and is more sensitive than spirometry for peripheral airway disease. In this study the efficacy of the combination of Indacaterol/Glycopirronium (IND/GLY) versus Tiotropium on airway resistance (R5, R20, R5-20), lung reactance (X) and resonant frequency in moderate to severe COPD patients has been evaluated...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28944531/short-term-respiratory-effects-of-e-cigarettes-in-healthy-individuals-and-smokers-with-asthma
#2
Andreas S Lappas, Anna S Tzortzi, Efstathia M Konstantinidi, Stephanie I Teloniatis, Chara K Tzavara, Sofia A Gennimata, Nikolaos G Koulouris, Panagiotis K Behrakis
BACKGROUND AND OBJECTIVE: This study investigated the duration of immediate respiratory effects of e-cigarette smoking (ECS) and tested the hypothesis that ECS has more prominent effects in asthmatics compared with healthy smokers (HS). METHODS: Fifty-four smokers, 27 healthy (HS group) and 27 with intermittent asthma (mild asthma (MA) group) underwent a control session (no liquid, no resistor coil inside e-cigarette cartridge) and an experimental session of ECS using standardized puffing settings...
September 24, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28940836/small-airway-involvement-in-the-late-allergic-response-in-asthma
#3
Henning Stenberg, Zuzana Diamant, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson
BACKGROUND: Allergy and asthma are closely linked. Inhalation of allergen induces an early allergic response (EAR) within the airways of allergic asthmatic subjects, which is followed by a late allergic response (LAR) in approximately 50% of the subjects. The LAR is defined as a drop in forced expiratory volume in 1 s (FEV1 ) from baseline usually occurring 4-8 h after exposure, and is believed to affect small airways. However, FEV1 is insensitive to changes in small airway physiology...
September 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28917529/bronchoprotective-effect-of-deep-inspirations-in-cough-variant-asthma-a-distinguishing-feature-in-the-spectrum-of-airway-disease
#4
Nastasia Wasilewski, Thomas Fisher, Scott E Turcotte, John T Fisher, M Diane Lougheed
PURPOSE: To assess the effect of deep inspirations (DIs) on airway behaviour in individuals with classic asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) during bronchoprovocation. METHODS: Twenty-five adults (18 female; 44.8±12.3years (Mean±SD); n=9 CA, n=9 CVA, and n=7 COUGH) completed two single-dose MCh challenges, with and without DIs. Bronchoprotection was assessed by comparing changes in bronchoconstriction (FEV1, FVC, FEV1/FVC, FEF50, FEF25-75), gas trapping (RV, RV/TLC) and impulse oscillometry (IOS) measurements...
September 13, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28846677/small-airway-dysfunction-in-smokers-with-stable-ischemic-heart-disease
#5
Claudia Llontop, Cristina Garcia-Quero, Almudena Castro, Regina Dalmau, Raquel Casitas, Raúl Galera, Alberto Iglesias, Elisabet Martinez-Ceron, Joan B Soriano, Francisco García-Río
BACKGROUND: A higher prevalence of airflow limitation (AL) has been described in patients with ischemic heart disease (IHD). Although small airway dysfunction (SAD) is an early feature of AL, there is little information about its occurrence in IHD patients. Our objective was to describe the prevalence of SAD in IHD patients, while comparing patient-related outcomes and future health risk among IHD patients with AL, SAD and normal lung function. METHODS: In 118 consecutive smoking patients with stable IHD, comorbidities, utilization of healthcare resources, current treatment, blood biochemistry and health status were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28845090/the-correlation-between-fstl1-expression-and-airway-remodeling-in-asthmatics
#6
Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao, Haiqing Zhang, Jiping Zhao, Junfei Wang, Lin Liu, Liuzhao Cao, Shuo Li, Jiawei Xu, Jianfeng Xu, Xiaohui Ma, Lei Yang, Liang Dong
BACKGROUND: Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES: To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. METHODS: We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28843062/impulse-oscillometry-and-obesity-in-children
#7
Maíra S de Assumpção, José D Ribeiro, Renata M G Wamosy, Fernanda C X S de Figueiredo, Paloma L F Parazzi, Camila I S Schivinski
OBJECTIVE: To compare impulse oscillometry system parameters of normal-weight children with overweight and obese children. METHOD: All participants were submitted to the evaluation of lung function (spirometry and impulse oscillometry) following the American Thoracic Society standards. The evaluation of respiratory mechanics was performed using the Jaeger™ MasterScreen™ Impulse Oscillometry System (Erich Jaeger, Germany), three tests were recorded, with acquisition for at least 20s...
September 8, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28839497/bronchodilator-response-assessment-of-the-small-airways-obstructive-pattern
#8
Plamen Bokov, Clémence Martin, Sémia Graba, Karine Gillet-Juvin, Mohamed Essalhi, Christophe Delclaux
BACKGROUND: A concomitant decrease in FEV1 and FVC with normal FEV1/FVC ratio and TLC defines small airways obstructive pattern (SAOP) and constitutes a classic pitfall of pulmonary-function-tests interpretation. OBJECTIVE: To evaluate the prevalence of flow- (FEV1 increase≥12% and 200 mL), volume- (FVC or inspiratory capacity [IC] increase≥12% and 200 mL), flow and volume-, and non-response to bronchodilation in patients with SAOP. An additional objective was to assess whether impulse oscillometry (IOS) parameters allow the diagnosis of SAOP and its reversibility...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28834381/small-airway-oscillometry-indices-repeatability-and-bronchodilator-responsiveness-in-young-children
#9
Hanna Knihtilä, Anne Kotaniemi-Syrjänen, Anna S Pelkonen, Satu Kalliola, Mika J Mäkelä, Leo Pekka Malmberg
INTRODUCTION: The impulse oscillometry (IOS) indices absolute and relative difference between respiratory resistance at 5 and 20 Hz (R5-20 and R5-20%, respectively) and the area under the reactance curve (AX) are postulated to reflect small airway function. Data on their cutoff values to evaluate bronchodilator responsiveness (BDR) or between-visit changes after interventions are limited in young children. METHODS: We evaluated the BDR of 103 healthy children aged 2-7 years, who received either salbutamol (n = 84) or placebo (n = 19) in order to determine cutoff values for BDR of R5-20, R5-20%, and AX...
October 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28822450/-evaluating-the-efficacy-of-fractional-exhaled-nitric-oxide-and-impulse-oscillometry-in-screening-out-cough-variant-asthma-from-patients-with-subacute-cough
#10
S Fang, S Y Chen, X He, Q X Shen, H Z Fan, X P Wu, Z K Fang, H P Yu
Objective: To evaluate the clinical value of fractional exhaled nitric oxide (FeNO) and impulse oscillometry (IOS) in screening out cough variant asthma (CVA) from patients with subacute cough. Methods: Patients with subacute cough were included from the outpatient department of Respiratory Medicine of Zhujiang Hospital of Southern Medical University from May to October in 2016. Based on "the guidelines for the diagnosis and treatment of cough (2015 edition)" , patients were classified into CVA group, and non CVP group with other causes of subacute cough...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28765495/validating-reference-equations-for-impulse-oscillometry-in-healthy-mexican-children
#11
Laura Gochicoa-Rangel, Rodrigo Del Río-Hidalgo, Juana Hernández-Ruiz, Luis Rodríguez-Moreno, David Martínez-Briseño, Uri Mora-Romero, Silvia Cid-Juárez, Cecilia García-Sancho, Luis Torre-Bouscoulet
BACKGROUND: The impulse oscillometry system (IOS) measures the impedance (Z) of the respiratory system, but proper interpretation of its results requires adequate reference values. The objectives of this work were: (1) to validate the reference equations for the IOS published previously by our group and (2) to compare the adjustment of new available reference equations for the IOS from different countries in a sample of healthy children. METHODS: Subjects were healthy 4-15-y-old children from the metropolitan area of Mexico City, who performed an IOS test...
August 1, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28760702/impulse-oscillometry-spirometry-and-passive-smoking-in-healthy-children-and-adolescents
#12
C I S Schivinski, M S de Assumpção, F C X S de Figueiredo, R M G Wamosy, L G Ferreira, J D Ribeiro
OBJECTIVE: To identify changes in the forced and quiet breathing parameters of lung function in healthy children and adolescents exposed to passive smoking (PS). METHOD: Comparative cross-sectional study. Healthy schoolchildren aged 6 to 14 years. We collected anthropometric data, lung function parameters using spirometry (forced breathing), and quiet breathing parameters using impulse oscillometry. The sample was divided into two groups according to exposure to PS: passive smoking group (PSG) and non-passive smoking group (NPSG)...
July 28, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28748646/small-airway-dysfunction-in-chronic-hypersensitivity-pneumonitis
#13
Selene Guerrero Zúñiga, Julia Sánchez Hernández, Heidegger Mateos Toledo, Mayra Mejía Ávila, Laura Gochicoa-Rangel, José Luis Miguel Reyes, Moisés Selman, Luis Torre-Bouscoulet
BACKGROUND AND OBJECTIVE: Lung biopsies from patients with hypersensitivity pneumonitis (HP) have demonstrated small airway (SA) involvement, but there is no information concerning SA function in HP, and it is unknown whether pharmacological treatment could modify its function. SA function in patients with chronic HP using ultrasonic pneumography (UPG) and impulse oscillometry (IOS) was explored. We also compared initial results with those obtained after 4 weeks of standardized treatment with azathioprine and prednisone...
November 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28747837/evaluation-of-pulmonary-functions-in-preschool-children-born-late-preterm
#14
İlkay Er, Ayla Günlemez, Zeynep Seda Uyan, Metin Aydoğan, Meral Oruç, Olcay Işık, Ayşe Engin Arısoy, Canan Baydemir, Ayşe Sevim Gökalp
AIM: The aim of this study was to evaluate the pulmonary functions of preschool children born late-preterm. MATERIAL AND METHODS: Children aged between 3-7 years who were born at 34(0/7-)36(6/7) weeks' gestation represented the target sample. Patients with a diagnosis of congenital cardiac, pulmonary and/or muscle diseases were excluded. Respiratory symptoms were evaluated using the modified asthma predictive index and International Study of Asthma and Allergies in Childhood criteria for children aged under and over 6 years, respectively...
June 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28666441/lung-function-development-after-preterm-birth-in-relation-to-severity-of-bronchopulmonary-dysplasia
#15
Petra Um-Bergström, Jenny Hallberg, Per Thunqvist, Eva Berggren-Broström, Martin Anderson, Gunilla Adenfelt, Gunnar Lilja, Giovanni Ferrara, C Magnus Sköld, Erik Melén
BACKGROUND: Bronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age. METHODS: Fifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13-17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry...
June 30, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28649293/small-airways-disease-and-severe-asthma
#16
REVIEW
Tara F Carr, Roula Altisheh, Myron Zitt
The small airways of the lungs are commonly affected in pediatric and adult asthma. Small airways disease has been related to asthma control, severity, and risk of exacerbation. Diagnosis of small airways disease can be best made through evaluation of surgical lung specimens. Noninvasive techniques including spirometry, plethysmography, nitrogen washout, impulse oscillometry, and cross-sectional imaging have been utilized to assess and infer the extent of small airways disease in asthma and can be used longitudinally to assess response to treatment...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28637400/impulse-oscillometry-system-and-anthropometric-variables-of-preschoolers-children-and-adolesctents-systematic-review
#17
Maíra Seabra De Assumpção, Emília da Silva Gonçalves, Marina Simões Oliveira, José Dirceu Ribeiro, Adyléia Aparecida Contrera Dalbo Toro, Antonio Azevedo Barros-Filho, Maria Ângela Reis Góes de Monteiro, Camila Isabel Santos Schivinski
BACKGROUND: To identify the anthropometric variables in equations/reference values of impulse oscillometry system (IOS) parameters in preschoolers, children and adolescents. METHOD: Systematic search on the databases MEDLINE/Ovid, SCOPUS and SciELO using the key words "preschool, child and adolescent", "impulse oscillometry", "reference values" and its variations. RESULTS: This review considered a total of 13 articles. The studies presented height, weight, sex and age as the variables correlated to oscillometric parameters...
June 21, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28583260/the-case-for-impulse-oscillometry-in-the-management-of-asthma-in-children-and-adults
#18
REVIEW
Stanley P Galant, Hirsh D Komarow, Hye-Won Shin, Salman Siddiqui, Brian J Lipworth
OBJECTIVE: To provide a clinical rationale for including impulse oscillometry (IOS) as a part of standard office-based asthma assessment. DATA SOURCES: PubMed and Google search, limited to English language and human disease, with the keywords IOS and asthma. STUDY SELECTIONS: Articles included in this review were based on the expert opinion and previous publications by the authors. RESULTS: In children, IOS was more useful than spirometry in identifying asthma and uncontrolled asthma and predicting loss of control and exacerbations...
June 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28579768/clinical-characteristics-of-copd-patients-with-tidal-expiratory-flow-limitation
#19
James Dean, Umme Kolsum, Paul Hitchen, Vandana Gupta, Dave Singh
We have used impulse oscillometry to identify COPD patients with tidal expiratory flow limitation (EFL), which is a measurement related to small airway disease. We report that 37.4% of COPD patients had EFL; these patients had multiple clinical characteristics of more severe disease including lower forced expiratory volume in 1 second values, greater hyperinflation, reduced exercise performance, and increased small airway impairment. We highlight that EFL can be used to identify a subgroup of COPD patients with distinct characteristics associated with small airway disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28453578/effects-of-a-mixture-of-chloromethylisothiazolinone-and-methylisothiazolinone-on-peripheral-airway-dysfunction-in-children
#20
Hyun-Ju Cho, Dong-Uk Park, Jisun Yoon, Eun Lee, Song-I Yang, Young-Ho Kim, So-Yeon Lee, Soo-Jong Hong
BACKGROUND: Children who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012. This study was to evaluate the pulmonary function using, impulse oscillometry (IOS) for children exposed to a mixture of CMIT/MIT from HD. METHODS: Twenty-four children who were only exposed to a mixture of CMIT/MIT, with no previous underlying disease, were assessed by IOS...
2017: PloS One
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