Aleksandra Plavsic, Branka Bonaci Nikolic, Branislava Milenkovic, Rada Miskovic, Natasa Kusic, Milan Dimitrijevic, Snezana Arandjelovic, Katarina Milosevic, Ivana Buha, Vesna Tomic Spiric
BACKGROUND AND OBJECTIVES: induced sputum is used to assess different inflammatory phenotypes in asthma, but is not used routinely. We aimed to determine the proportion of inflammatory asthma phenotypes based on induced sputum, to find biomarkers that can discriminate between phenotypes, and to evaluate biomarkers in patients with and without biological therapy in different inflammatory asthma phenotypes. MATERIALS AND METHODS: this cross-sectional study investigated clinical characteristics, asthma control tests, skin prick test, impulse oscillometry (IOS), spirometry, induced sputum, biomarkers (IgE, eosinophils, fractional exhaled nitric oxide (FeNO), serum periostin, IL-5, IL-6, IL-8, IL-17A, IL-33) in 80 asthmatics...
January 17, 2024: Journal of Clinical Medicine