keyword
https://read.qxmd.com/read/38546237/should-atelectasis-be-considered-a-pulmonary-complication-and-indicator-of-poor-prognosis-in-cystic-fibrosis
#1
JOURNAL ARTICLE
María Martínez Redondo, Carlos Carpio Segura, Ester Zamarrón De Lucas, Rodolfo Álvarez-Sala Walther, Concepción Prados Sánchez
OBJECTIVE: This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF. METHODS: This multicenter, case-control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis who were followed-up at least for 2 years) and a control group (patients without atelectasis matched 1:1 by sex and age [±3 years])...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38546004/pediatric-pulmonology-year-in-review-2023-physiology
#2
REVIEW
Heather Boas, Clement L Ren
Application of the principles of pulmonary physiology and lung development to the care and management of respiratory disease in children is a distinguishing feature of pediatric pulmonology. In 2023, this was evident in numerous publications in Pediatric Pulmonology and other journals. This review will highlight some of the papers in this area.
March 28, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38542673/the-influence-of-high-dose-parenteral-vitamin-c-on-the-incidence-and-severity-of-postoperative-pulmonary-complications-in-cardiac-surgery-with-extracorporeal-circulation-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Milica Karadžić Kočica, Arsen Ristić, Ivan Soldatović, Dejan Lazović, Jelena Čumić, Miloš Grujić, Radmila Karan, Duško Terzić, Ivan Palibrk, Mladen Kočica, Dejan Marković
Cardiac surgery (CS) with extracorporeal circulation (ECC), induces intense oxidative stress (OS) and systemic inflammatory response (SIR), which may seriously affect postoperative lung function. We aimed to test if high parenteral (200 mg/kg/24 h) daily doses of Vitamin C (VitC), given within 48 h after the beginning of the operation, may reduce the incidence and severity of postoperative pulmonary complications (PPCs) in CS patients. This single-center, prospective, randomized, single-blinded, interventional trial included 150 patients, assigned to control Group A ( n = 75) and interventional Group B ( n = 75)...
March 7, 2024: Nutrients
https://read.qxmd.com/read/38541172/lower-arginine-bioavailability-increased-feno-levels-and-airway-resistance-on-impulse-oscillometry-are-characteristics-of-asthma-in-children-and-young-adults-with-sickle-cell-disease
#4
JOURNAL ARTICLE
Aylin Kont Ozhan, Tugba Arikoglu, Melih Er, Selma Unal, Didem Derici Yıldırım, Funda Erkasar, Şenay Balcı, Lulufer Tamer, Semanur Kuyucu
Background and Objectives : Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention in the pathogenesis of asthma and SCD. This study aimed to determine the distinctive clinical and laboratory features and the role of arginine metabolism in asthmatic children with SCD. Materials and Methods : A total of 52 children and adolescents with SCD, including 24 with asthma (SCD-A) and 28 without asthma (SCD-NA), and 40 healthy controls were included...
March 8, 2024: Medicina
https://read.qxmd.com/read/38541113/severe-asthma-or-chronic-obstructive-pulmonary-disease-with-eosinophilic-inflammation-from-uncertainty-to-remission-under-anti-il-5r-therapy
#5
Bianca Oprescu, Oana Raduna, Stefan Mihaicuta, Stefan Frent
Background and Objectives : Severe adult-onset eosinophilic asthma and COPD with eosinophilic inflammation are two entities with a similar clinical course and are sometimes difficult to differentiate in clinical practice, especially in patients with a history of smoking. Anti-IL-5 or -IL-5R biological therapy has been shown to be highly effective in severe eosinophilic asthma but has not demonstrated significant benefit in patients with COPD with the eosinophilic phenotype. Our aim was to illustrate this issue in the form of a case report...
February 25, 2024: Medicina
https://read.qxmd.com/read/38539812/ischemia-modified-albumin-ima-is-associated-with-poor-survival-in-patients-with-newly-diagnosed-idiopathic-pulmonary-fibrosis-ipf-a-pilot-study
#6
JOURNAL ARTICLE
Angelo Zinellu, Stefano Zoroddu, Simona Fois, Sabrina Mellino, Chiara Scala, Erika Virdis, Elisabetta Zinellu, Salvatore Sotgia, Panagiotis Paliogiannis, Arduino A Mangoni, Ciriaco Carru, Pietro Pirina, Alessandro G Fois
There are increasing efforts to better predict adverse outcomes for idiopathic pulmonary fibrosis (IPF). Our aim was to assess the prognostic potential of ischemia-modified albumin (IMA), an established circulating marker of ischemia and, more recently, oxidative stress, in a cohort of 56 IPF patients recruited between 2015 and 2023 at the University of Sassari, Italy. Demographic and functional parameters and serum IMA concentrations were measured at baseline. Non-survivors had significantly higher IMA concentrations vs...
February 25, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38536558/a-deep-learning-model-for-translating-ct-to-ventilation-imaging-analysis-of-accuracy-and-impact-on-functional-avoidance-radiotherapy-planning
#7
JOURNAL ARTICLE
Zhen Hou, Youyong Kong, Junxian Wu, Jiabing Gu, Juan Liu, Shanbao Gao, Yicai Yin, Ling Zhang, Yongchao Han, Jian Zhu, Shuangshuang Li
PURPOSE: Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study introduces a novel deep-learning model directly translating planning CT images into CTVI. We investigated the accuracy of generated images and the impact on functional avoidance planning. MATERIALS AND METHODS: Paired planning CT and 4DCT scans from 48 patients with NSCLC were randomized to training (n = 41) and testing (n = 7) data sets...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#8
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38533528/silencing-of-circ_0088036-inhibits-growth-and-invasion-of-lung-adenocarcinoma-through-mir-203-sp1-axis
#9
JOURNAL ARTICLE
Xiuhua Liu, Yan Feng, Linna Wang, Lei Shi, Kunxiang Ji, Nan Hu, Yang Du, Mingyang Liu, Man Wang
Lung cancer is the leading cause of cancer-related deaths worldwide. Circular RNA (circRNA) circ_0088036 is a recently discovered circRNA known for its roles in rheumatoid arthritis. The study aimed to study the function of circ_0088036 in lung adenocarcinoma (LUAD). Circ_0088036 expressions were analyzed in the Gene Expression Omnibus (GEO) database. The relationship between circ_0088036 expressions and clinicopathological data of LUAD was assessed. The messenger RNA and protein levels were analyzed by quantitative real-time polymerase chain reaction and Western blot...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38532684/malignance-restriction-activity-exhibited-by-bioactive-compounds-of-selected-actinobacteria-as-silver-nanoparticles-against-a549-lung-cancer-cell-lines
#10
JOURNAL ARTICLE
Naushin Bano, Anamika Gupta, Mohammad Amir, Mohd Rehan Zaheer, Roohi Roohi
This article deals with the antibacterial and anticancer potential of secondary metabolites produced by actinomycetes also reported as actinobacteria, Microbacterium proteolyticum (MN560041), and Streptomycetes rochei, where preliminary studies were done with the well diffusion method. These actinobacteria's silver nanoparticles were synthesized and characterized using transmission electron microscopy (TEM) and UV-Visible spectroscopy. Anticancer was measured using the MTT test, reactive oxygen species (ROS) generation measured with DCFDA, mitochondrial membrane potential (MMP) measurement, and DAPI fluorescence intensity activity was measured in treated and non-treated cancerous cells...
April 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38532368/screening-and-staging-of-chronic-obstructive-pulmonary-disease-with-deep-learning-based-on-chest-x-ray-images-and-clinical-parameters
#11
MULTICENTER STUDY
XiaoLing Zou, Yong Ren, HaiLing Yang, ManMan Zou, Ping Meng, LiYi Zhang, MingJuan Gong, WenWen Ding, LanQing Han, TianTuo Zhang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is underdiagnosed with the current gold standard measure pulmonary function test (PFT). A more sensitive and simple option for early detection and severity evaluation of COPD could benefit practitioners and patients. METHODS: In this multicenter retrospective study, frontal chest X-ray (CXR) images and related clinical information of 1055 participants were collected and processed. Different deep learning algorithms and transfer learning models were trained to classify COPD based on clinical data and CXR images from 666 subjects, and validated in internal test set based on 284 participants...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38532301/safety-of-lung-resection-surgery-after-severe-acute-respiratory-syndrome-coronavirus-2-infection-in-the-post-vaccination-era
#12
JOURNAL ARTICLE
Somin Im, Kwon Joong Na, Ji Hyeon Park, Bubse Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim
OBJECTIVES: To investigate the post-operative outcomes of lung resection in patients with SARS-CoV-2 infection and determine the optimal timing of surgery. METHODS: This retrospective, single-center cohort study included patients who underwent lung resection between June 2021 and June 2022. Patients were divided into the COVID-19 and non-COVID-19 groups based on their pre-operative SARS-CoV-2 infection history, and post-operative outcomes were compared. Logistic regression analysis was conducted to identify the risk factors of complications after lung resection surgery...
March 26, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38531325/predicting-exacerbations-in-%C3%AE-1-antitrypsin-deficiency-using-clinical-and-pulmonary-function-tests-portuguese-earco-registry
#13
JOURNAL ARTICLE
Nuno Faria, Joana Gomes, Catarina Guimarães, Raquel Marçôa, Beatriz Ferraz, Maria Sucena
INTRODUCTION: Exacerbations are common in individuals with alpha-1-antitrypsin deficiency (AATD) related lung disease. This study intended to identify independent predictive factors for exacerbations in AATD using the Portuguese European Alpha-1 Research Collaboration (EARCO) registry. METHODS: This study includes patients from the Portuguese EARCO registry, a prospective multicentre cohort (NCT04180319). From October 2020 to April 2023 this registry enrolled 137 patients, 14 of whom were excluded for analysis for either missing 12 months of follow-up or baseline pulmonary function...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38530208/fitness-level-and-sex-related-differences-in-pulmonary-limitations-to-maximal-exercise-in-normoxia-and-hypoxia
#14
JOURNAL ARTICLE
Antoine Raberin, Giorgio Manferdelli, Forrest Schorderet, Nicolas Bourdillon, Grégoire P Millet
PURPOSE: Both maximal-intensity exercise and altitude exposure challenge the pulmonary system that may reach its maximal capacities. Expiratory flow limitation (EFL) and exercise-induced hypoxemia (EIH) are common in endurance-trained athletes. Furthermore, due to their smaller airways and lung size, women, independently of their fitness level, may be more prone to pulmonary limitations during maximal-intensity exercise; particularly when performed in hypoxic conditions. The objective of this study was to investigate the impact of sex and fitness level on pulmonary limitations during maximal exercise in normoxia and their consequences in acute hypoxia...
March 25, 2024: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38530178/case-323-minute-pulmonary-meningothelial-like-nodules
#15
JOURNAL ARTICLE
Furkan Ufuk, Emel Kilicarslan, Ferda Bir, Goksel Altinisik
A 70-year-old woman with a 6-year history of asthma, a 12-year history of diabetes mellitus, and who did not smoke presented to the pulmonology clinic with dyspnea and cough. Chest CT performed 5 years earlier for similar symptoms revealed multiple pulmonary nodules. However, she was lost to follow-up before the work-up was concluded. Otherwise, her medical history was unremarkable. Family history included maternal endometrial cancer. Physical examination revealed partial oxygen saturation of 98%, respiratory rate of 18 breaths per minute, and heart rate of 77 beats per minute...
March 2024: Radiology
https://read.qxmd.com/read/38530131/precision-delivery-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-the-pancreas-via-intra-arterial-injection-prevents-the-onset-of-diabetes
#16
JOURNAL ARTICLE
Rosita Primavera, Shobha Regmi, Reza Yarani, Steven Levitte, Jing Wang, Abantika Ganguly, Shashank Chetty, Michele Guindani, Camillo Ricordi, Everett Meyer, Avnesh S Thakor
Mesenchymal stem cells (MSCs) are a promising therapy to potentially treat diabetes given their potent anti-inflammatory and immune-modulatory properties. While these regenerative cells have shown considerable promise in cell culture, their clinical translation has been challenging. In part, this can be attributed to these cells not reaching the pancreas to exert their regenerative effects following conventional intravenous (IV) injection, with the majority of cells being trapped in the lungs in the pulmonary first-pass effect...
March 26, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38526698/compensatory-expansion-of-the-right-middle-lobe-volumetric-and-functional-analysis-of-the-changes-after-right-upper-or-lower-lobectomy
#17
JOURNAL ARTICLE
Takamasa Shibazaki, Shohei Mori, Satoshi Arakawa, Yo Tsukamoto, Takeo Nakada, Yusuke Takahashi, Takashi Ohtsuka
The right middle lobe often poorly expands after right upper lobectomy. Postoperative pulmonary function may be inferior after right upper lobectomy than after right lower lobectomy due to poor expansion of the middle lobe. This study examined the difference in the postoperative right middle lobe expansion and pulmonary function between right upper and right lower lobectomy. Patients who underwent right upper or right lower lobectomy through video-assisted thoracic surgery (n = 82) were enrolled in this retrospective study...
March 25, 2024: Updates in Surgery
https://read.qxmd.com/read/38525738/epigenetic-features-in-newborns-associated-with-preadolescence-lung-function-and-asthma-acquisition-during-adolescence
#18
JOURNAL ARTICLE
Mohammad Nahian Ferdous Abrar, Yu Jiang, Hongmei Zhang, Liang Li, Hasan Arshad
UNLABELLED: The association between newborn DNA methylation (DNAm) and asthma acquisition (AA) during adolescence has been suggested. Lung function (LF) has been shown to be associated with asthma risk and its severity. However, the role of LF in the associations between DNAm and AA is unclear, and it is also unknown whether the association between DNAm and AA is consistent with that between DNAm and LF. We address this question through assessing newborn epigenetic features of preadolescence LF and of AA during adolescence, along with their biological pathways and processes...
March 22, 2024: Epigenomes
https://read.qxmd.com/read/38524030/graded-mobilization-with-pacing-technique-for-functional-mobility-in-a-preoperative-marfan-syndrome-case-of-aortic-root-dilation-a-case-report
#19
Sawari S Bhagwatkar, Vaishnavi Yadav, Prajyot Ankar, Neha Arya
Marfan syndrome (MFS) presents complex cardiovascular manifestations and challenges in management due to its impact on multiple body systems. This case study examines the clinical profile, diagnostic findings, and physiotherapy intervention for a 57-year-old male with MFS who experienced severe aortic and mitral valvular complications. The patient's admission was marked by fatigue, reduced mobility, breathlessness, and a confirmed diagnosis of MFS. Cardiac evaluation revealed severe regurgitation and aortic root dilation...
February 2024: Curēus
https://read.qxmd.com/read/38523925/surgical-resection-of-a-pneumothorax-in-an-adult-patient-with-a-history-of-wilson-mikity-syndrome-diagnosed-in-childhood
#20
Ryusei Yoshino, Masaki Nakatsubo, Nanami Ujiie, Masahiro Kitada
Wilson-Mikity syndrome (WMS) is a rare condition characterized by various respiratory and pulmonary abnormalities in neonates and infants. However, the diagnosis is based on the findings of physiological tests, such as respiratory function tests. Reports describing the histopathological features of WMS are limited. The patient was a 22-year-old woman with a history of WMS. She had been on a ventilator for the first three months of life due to pulmonary hypertension after early delivery at 24 weeks of gestation and required oxygen therapy until three years of age...
February 2024: Curēus
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