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cobalt AND pregnancy

Mary E Ingle, Michael S Bloom, Patrick J Parsons, Amy J Steuerwald, Pamela Kruger, Victor Y Fujimoto
PURPOSE: A hypothesis-generating pilot study exploring associations between essential trace elements measured in follicular fluid (FF) and urine and in vitro fertilization (IVF) endpoints. METHODS: We recruited 58 women undergoing IVF between 2007 and 2008, and measured cobalt, chromium, copper, manganese, molybdenum, and zinc in FF (n = 46) and urine (n = 45) by inductively coupled plasma mass spectrometry (ICP-MS). We used multivariable regression models to assess the impact of FF and urine trace elements on IVF outcomes, adjusted for age, body mass index, race, and cigarette smoking...
December 9, 2016: Journal of Assisted Reproduction and Genetics
Lailai Yan, Bin Wang, Zhenjiang Li, Yaqiong Liu, Wenhua Huo, Jingyu Wang, Zhiwen Li, Aiguo Ren
BACKGROUND: The relationship between essential trace metals (ETMs) and the risk of neural tube defects (NTDs) is still unclear. One of the challenges is to evaluate the intake of ETMs of women during their early period of pregnancy. We proposed the hypothesis that an ETM deficiency in women during their early period of pregnancy is associated with an elevated risk of NTDs in offspring. METHODS: We recruited 191 women with NTD-affected pregnancies (case group) and 261 women who delivered healthy infants (control group)...
December 5, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
Rihwa Choi, Jiyu Sun, Heejin Yoo, Seonwoo Kim, Yoon Young Cho, Hye Jeong Kim, Sun Wook Kim, Jae Hoon Chung, Soo-Young Oh, Soo-Youn Lee
This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4-40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed...
November 23, 2016: Nutrients
Jyotirmayee Bahinipati, Prakash Chandra Mohapatra
INTRODUCTION: Normal pregnancy is always associated with immense stress in order to accommodate the increasing demands of the developing fetus. Various metabolic changes along with vascular remodeling occur in maternal system. Due to this, pregnancy is always associated with oxidative stress and generation of Reactive Oxygen Species (ROS). Ischemia Modified Albumin (IMA) generated by ROS is found to be sensitive and early biochemical marker of ischemic heart disease and now used as an important marker to distinguish between ischemic and non-ischemic pathologies...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
C Abán, N Martinez, C Carou, I Albamonte, A Toro, A Seyahian, A Franchi, G Leguizamón, D Trigubo, A Damiano, M Farina
During pregnancy, apoptosis is a physiological event critical in the remodeling and aging of the placenta. Increasing evidence has pointed towards the relevance of endocannabinoids (ECs) and hypoxia as modulators of trophoblast cell death. However, the relation between these factors is still unknown. In this report, we evaluated the participation of ECs in placental apoptosis induced by cobalt chloride (CoCl2), a hypoxia mimicking agent that stabilizes the expression of hypoxia inducible factor-1 alpha (HIF-1α)...
October 2016: Apoptosis: An International Journal on Programmed Cell Death
R S Marques, R F Cooke, M C Rodrigues, B I Cappellozza, R R Mills, C K Larson, P Moriel, D W Bohnert
Eighty-four multiparous, nonlactating, pregnant Angus × Hereford cows were ranked by pregnancy type (56 AI and 28 natural service), BW, and BCS and allocated to 21 drylot pens at the end of their second trimester of gestation (d 0). Pens were assigned to receive forage-based diets containing 1) sulfate sources of Cu, Co, Mn, and Zn (INR); 2) an organic complexed source of Cu, Mn, Co, and Zn (AAC; Availa 4; Zinpro Corporation, Eden Prairie, MN); or 3) no supplemental Cu, Co, Mn, and Zn (CON). Diets were offered from d 0 until calving and formulated to meet requirements for energy, protein, macrominerals, Se, I, and vitamins...
March 2016: Journal of Animal Science
Lorena Bermúdez, Consuelo García-Vicent, Jorge López, Maria Isabel Torró, Empar Lurbe
BACKGROUND: Trace elements are an essential nutritional component for humans and inadequate tissue-concentrations may have a significant effect on fetal size. OBJECTIVE: To measure ten trace elements in blood samples from mothers and their newborns, and assess their association with anthropometric characteristics at birth. The effects of other factors on fetal growth, such as biologic characteristics of the infant and mother, were analysed. METHODS: A cross-sectional study was conducted in the Hospital general, University of Valencia, Spain...
2015: Journal of Translational Medicine
Koumei Shirasuna, Narumi Shimamura, Kotomi Seno, Ayaka Ohtsu, Shogo Shiratsuki, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Shiho Nagayama, Hisataka Iwata, Takehito Kuwayama
BACKGROUND/AIMS: The placenta is a vital organ for pregnancy. Many in vitro placental experiments are conducted under 21% O2; however, O2 tension could influence cellular functions, including cytokine secretion. We investigated the effects of oxygen tension between moderate hypoxia (5% O2) and normoxia (21% O2) by testing the hypothesis that moderate hypoxia regulates cellular phenotypes differently from normoxia in human trophoblast cells. METHODS AND RESULTS: Sw...
2015: Cellular Physiology and Biochemistry
C Linscheid, E Heitmann, P Singh, E Wickstrom, L Qiu, H Hodes, T Nauser, M G Petroff
INTRODUCTION: Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and whether HA-1 expression is altered in preeclamptic placentas. METHODS: Expression and regulation of HA-1 mRNA and protein were examined by qRT-PCR and immunohistochemistry, using first, second, and third trimester placentas, first trimester placental explant cultures, and term purified cytotrophoblast cells...
August 2015: Placenta
Marc Oppermann, Cornelia Borisch, Christof Schaefer
Metal-on-metal arthroplasty may lead to elevated blood chromium (Cr) and cobalt (Co) levels (>7 μg/l). Since carcinogenic, mutagenic, and teratogenic effects have been suggested, there is concern of pregnancy hazards for women with this condition. The 34-year-old patient has had a unilateral hip replacement for seven years. Before her pregnancy high Cr (47 μg/l) and Co (103 μg/l) blood concentrations were measured, but she did not develop any symptoms. A male infant was delivered after 41 weeks with first degree hypospadias...
June 2015: Reproductive Toxicology
Eric M George, Joey P Granger
OBJECTIVES: Despite intensive research, little in the way of new therapeutics has been developed for the preeclampsia patient. Several in vitro reports have suggested that heme oxygenase (HO) and its metabolic byproducts could inhibit known pathological pathways active in preeclampsia; specifically sFlt-1 production, oxidative stress, and innate immune activation. Here, we investigated the potential of HO induction, or the administration of its metabolic byproducts carbon monoxide and bilirubin, to act as a palliative in preclinical models of pregnancy-induced hypertension and preeclampsia...
January 2015: Pregnancy Hypertension
Clifford C Novak, Andrew R Hsu, Craig J Della Valle, Anastasia K Skipor, Patricia Campbell, Harlan C Amstutz, William A Jiranek, Aham Onyike, Xavier F Pombar, Joshua J Jacobs
There is concern regarding elevated metal ion levels in the blood during pregnancy and the potential fetal effects in women with metal-on-metal (MOM) implants. We obtained maternal and umbilical cord blood samples from 3 patients with a MOM hip arthroplasty and 7 control subjects without any metallic implants. Serum metal ion levels including chromium, cobalt, titanium, and nickel were tested using high-resolution sector-field inductively-coupled plasma-mass spectrometry. Mothers with MOM-bearing implants had significantly elevated levels of serum cobalt and chromium compared with control-group mothers, and umbilical cord blood from mothers with MOM implants also had significantly higher serum metal ion levels compared with control-group mothers...
December 2014: American Journal of Orthopedics
Marta Fort, Joan O Grimalt, Maribel Casas, Jordi Sunyer
Cobalt is an essential trace element but may cause toxic effects upon occupational or environmental exposure. Women accumulate more cobalt than men at similar exposure levels which may be related to higher metabolic iron loss. During pregnancy these losses are much stronger but their influence on cobalt intake has not been studied. We have studied the associations between changes in hemoglobin and cobalt urinary excretion during pregnancy. 391 pairs of urine and blood samples from pregnant women were collected during the 12th and 32nd weeks of pregnancy and were analyzed for cobalt and hemoglobin...
January 2015: Environmental Research
Guanchao Zheng, Hongxiu Zhong, Zhizhun Guo, Zhuangchu Wu, Huaiqing Zhang, Chonggang Wang, Yulin Zhou, Zhenghong Zuo
To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elements concentrations were determined by inductively coupled plasma-mass spectrometry. No differences with statistical significance in the median arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), strontium (Sr), thallium (Tl), vanadium (V), and zinc (Zn) concentrations were observed between the adverse pregnancy outcome group and the reference group...
September 2014: Biological Trace Element Research
Tali Silberstein, Magal Saphier, Yardena Mashiach, Ofra Paz-Tal, Oshra Saphier
OBJECTIVE: Knowledge about levels of toxic and non-toxic elements in amniotic fluid is limited. The aims of this study were: (1) to measure levels of trace elements Cu, Fe, Zn, B, Sr and Co in amniotic fluid and maternal serum during second trimester of pregnancy; and (2) to determine what correlations exists between elements levels in amniotic fluid and maternal serum. METHODS: The levels of, iron, copper, zinc, cobalt, strontium and boron were measured in blood and amniotic fluid during genetic amniocentesis using inductively coupled plasma mass spectrometry (ICP-MS)...
January 2015: Journal of Maternal-fetal & Neonatal Medicine
Marta Fort, Marta Cosín-Tomás, Joan O Grimalt, Xavier Querol, Maribel Casas, Jordi Sunyer
Prenatal exposure to trace metals, whether they are essential, non-essential, or toxic, must be assessed for their potential health effects in the offspring. Herein is reported an approach to this end which involved collection of urine samples during the first and third trimesters of pregnancy from 489 mothers from Sabadell (Catalonia, Spain), a highly industrialized town. These samples were analyzed for cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), selenium (Se), arsenic (As), molybdenum (Mo), cadmium (Cd), antimonium (Sb), cesium (Cs), thallium (Tl), and lead (Pb)...
2014: Environmental Science and Pollution Research International
Junie P Warrington, Kayla Coleman, Courtney Skaggs, Peter A Hosick, Eric M George, David E Stec, Michael J Ryan, Joey P Granger, Heather A Drummond
Preeclampsia is thought to arise from inadequate cytotrophoblast migration and invasion of the maternal spiral arteries, resulting in placental ischemia and hypertension. Evidence suggests that altered expression of epithelial Na(+) channel (ENaC) proteins may be a contributing mechanism for impaired cytotrophoblast migration. ENaC activity is required for normal cytotrophoblast migration. Moreover, β-ENaC, the most robustly expressed placental ENaC message, is reduced in placentas from preeclamptic women...
May 2014: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Joan Forns, Marta Fort, Maribel Casas, Alejandro Cáceres, Mònica Guxens, Mireia Gascon, Raquel Garcia-Esteban, Jordi Julvez, Joan O Grimalt, Jordi Sunyer
BACKGROUND: There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. OBJECTIVES: Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age...
January 2014: Neurotoxicology
Mikiko Yamanaka-Tatematsu, Akitoshi Nakashima, Naonobu Fujita, Tomoko Shima, Tamotsu Yoshimori, Shigeru Saito
Extravillous trophoblasts (EVTs) characterize the invasion of the maternal decidua under low oxygen and poor nutrition at the early feto-maternal interface to establish a successful pregnancy. We previously reported that autophagy in EVTs was activated under 2% O2 in vitro, and autophagy activation was also observed in EVTs at the early feto-maternal interface in vivo. Here, we show that autophagy is an energy source for the invasion of EVTs. Cobalt chloride (CoCl2), which induces hypoxia inducible factor 1α (HIF1α) overexpression, activated autophagy in HTR8/SVneo cells, an EVT cell line...
2013: PloS One
Elmouldi Garoui, Ibtissem Ben Amara, Dorra Driss, Awatef Elwej, Semia Ellouze Chaabouni, Tahia Boudawara, Najiba Zeghal
Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls...
September 2013: Biological Trace Element Research
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