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https://www.readbyqxmd.com/read/29149021/using-gamma-and-quantile-regressions-to-explore-the-association-between-job-strain-and-adiposity-in-the-elsa-brasil-study-does-gender-matter
#1
Maria de Jesus Mendes da Fonseca, Leidjaira Lopes Juvanhol, Lúcia Rotenberg, Aline Araújo Nobre, Rosane Härter Griep, Márcia Guimarães de Mello Alves, Letícia de Oliveira Cardoso, Luana Giatti, Maria Angélica Nunes, Estela M L Aquino, Dóra Chor
This paper explores the association between job strain and adiposity, using two statistical analysis approaches and considering the role of gender. The research evaluated 11,960 active baseline participants (2008-2010) in the ELSA-Brasil study. Job strain was evaluated through a demand-control questionnaire, while body mass index (BMI) and waist circumference (WC) were evaluated in continuous form. The associations were estimated using gamma regression models with an identity link function. Quantile regression models were also estimated from the final set of co-variables established by gamma regression...
November 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29145880/anti-nf155-chronic-inflammatory-demyelinating-polyradiculoneuropathy-strongly-associates-to-hla-drb15
#2
Laura Martinez-Martinez, Ma Cinta Lleixà, Gemma Boera-Carnicero, Andrea Cortese, Jérôme Devaux, Ana Siles, Yusuf Rajabally, Alicia Martinez-Piñeiro, Alejandra Carvajal, Julio Pardo, Emilien Delmont, Shahram Attarian, Jordi Diaz-Manera, Ilaria Callegari, Enrico Marchioni, Diego Franciotta, Luana Benedetti, Guiseppe Lauria, Oscar de la Calle Martin, Cándido Juárez, Isabel Illa, Luis Querol
BACKGROUND: The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. METHODS: Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele...
November 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29145480/engineering-the-gh1-%C3%AE-glucosidase-from-humicola-insolens-insights-on-the-stimulation-of-activity-by-glucose-and-xylose
#3
Luana Parras Meleiro, José Carlos Santos Salgado, Raquel Fonseca Maldonado, Sibeli Carli, Luiz Alberto Beraldo Moraes, Richard John Ward, João Atílio Jorge, Rosa Prazeres Melo Furriel
The activity of the GH1 β-glucosidase from Humicola insolens (Bglhi) against p-nitrophenyl-β-D-glucopyranoside (pNP-Glc) and cellobiose is enhanced 2-fold by glucose and/or xylose. Kinetic and transglycosylation data showed that hydrolysis is preferred in the absence of monosaccharides. Stimulation involves allosteric interactions, increased transglycosylation and competition of the substrate and monosaccharides for the -1 glycone and the +1/+2 aglycone binding sites. Protein directed evolution has been used to generate 6 mutants of Bglhi with altered stimulation patterns...
2017: PloS One
https://www.readbyqxmd.com/read/29143782/sustainable-bio-based-phenol-formaldehyde-resoles-using-hydrolytically-depolymerized-kraft-lignin
#4
Homaira Siddiqui, Nubla Mahmood, Zhongshun Yuan, Ferdinando Crapulli, Luana Dessbesell, Amin Rizkalla, Ajay Ray, Chunbao Charles Xu
In this study bio-based bio-phenol-formaldehyde (BPF) resoles were prepared using hydrolytically depolymerized Kraft lignin (DKL) as bio-phenol to partially substitute phenol. The effects of phenol substitution ratio, weight-average molecular weight (Mw) of DKL and formaldehyde-to-phenol (F/P) ratio were also investigated to find the optimum curing temperature for BPF resoles. The results indicated that DKL with Mw ~ 1200 g/mol provides a curing temperature of less than 180 °C for any substitution level, provided that F/P ratios are controlled...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29141021/correction-targeting-neutrophils-to-prevent-malaria-associated-acute-lung-injury-acute-respiratory-distress-syndrome-in-mice
#5
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino-Neto, Momtchilo Russo, Maria R D' Império Lima, José M Alvarez, Silvia Portugal, Claudio R F Marinho, Sabrina Epiphanio
[This corrects the article DOI: 10.1371/journal.ppat.1006054.].
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29137319/effects-of-growth-hormone-on-cardiac-remodeling-and-soleus-muscle-in-rats-with-aortic-stenosis-induced-heart-failure
#6
Aline R R Lima, Luana U Pagan, Ricardo L Damatto, Marcelo D M Cezar, Camila Bonomo, Mariana J Gomes, Paula F Martinez, Daniele M Guizoni, Dijon H S Campos, Felipe C Damatto, Katashi Okoshi, Marina P Okoshi
Background: Skeletal muscle wasting is often observed in heart failure (HF). The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis is impaired in HF. In this study, we evaluated the effects of GH on soleus muscle and cardiac remodeling in rats with aortic stenosis (AS)-induced HF. Methods: AS was created by placing a stainless-steel clip on the ascending aorta. After clinically detecting HF, GH (2 mg/kg/day) was subcutaneously injected for 14 days (AS-GH group)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134339/feline-immudeficiency-virus-subtypes-b-and-a-in-cats-from-s%C3%A3-o-luis-maranh%C3%A3-o-brazil
#7
Nathálya Dos S Martins, Ana Paula de S Rodrigues, Luciana A da Luz, Luana da L Dos Reis, Renata M de Oliveira, Rudson A de Oliveira, Ana Lucia Abreu-Silva, Jenner Karlisson P Dos Reis, Ferdinan A Melo
Feline immunodeficiency virus (FIV) is a retrovirus of the genus Lentivirus that is distributed worldwide, with prevalence rates varying between 2.5% and 44%. FIV causes immunosuppression, with depletion of TCD4(+) lymphocytes, with the majority of clinical signs caused by secondary and opportunistic infections. Blood samples were collected from nine domestic cats (Felis catus domesticus) from the city of São Luís, Maranhão State, Brazil. All samples were positive in a rapid immunochromatographic test (SNAP® Combo FeLV Ag/FIV Antibody Test) and in a polymerase chain reaction (PCR) assay...
November 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29132407/frequency-and-determinants-for-hemorrhagic-transformation-of-posterior-cerebral-stroke-posterior-ischemic-stroke-and-hemorrhagic-transformation
#8
Francesca Valentino, Luana Gentile, Valeria Terruso, Sergio Mastrilli, Paolo Aridon, Paolo Ragonese, Caterina Sarno, Giovanni Savettieri, Marco D'Amelio
BACKGROUND: hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Patients with posterior circulation stroke were seen in our Department during the period January 2004 to December 2009...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29128335/hereditary-angioedema-with-normal-c1-inhibitor-and-f12-mutations-in-42-brazilian-families
#9
Camila Lopes Veronez, Adriana S Moreno, Rosemeire Navickas Constantino-Silva, Luana S M Maia, Mariana P L Ferriani, Fábio F M Castro, Solange Rodrigues Valle, Victor Koji Nakamura, Nathália Cagini, Rozana Fátima Gonçalves, Eli Mansour, Faradiba Sarquis Serpa, Gabriela Andrade Coelho Dias, Miguel Alberto Piccirillo, Eliana Toledo, Marli de Souza Bernardes, Sven Cichon, Christiane Stieber, L Karla Arruda, João Bosco Pesquero, Anete Sevciovic Grumach
BACKGROUND: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent. OBJECTIVES: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29127943/quantum-dot-cramoll-lectin-as-novel-conjugates-to-glycobiology
#10
Cássia R A Cunha, Camila G Andrade, Maria I A Pereira, Paulo E Cabral Filho, Luiz B Carvalho, Luana C B B Coelho, Beate S Santos, Adriana Fontes, Maria T S Correia
The optical properties of quantum dots (QDs) make them useful tools for biology, especially when combined with biomolecules such as lectins. QDs conjugated to lectins can be used as nanoprobes for carbohydrate expression analysis, which can provide valuable information about glycosylation changes related to cancer and pathogenicity of microorganisms, for example. In this study, we evaluated the best strategy to conjugate Cramoll lectin to QDs and used the fluorescent labeling of Candida albicans cells as a proof-of-concept...
October 25, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29127050/do-antibacterial-and-antifungal-combinations-have-better-activity-against-clinically-relevant-fusarium-species-in-vitro-synergism
#11
Tarcieli Pozzebon Venturini, Abdullah M S Al-Hatmi, Luana Rossato, Maria Isabel Azevedo, Jéssica Tairine Keller, Carla Weiblen, Janio Morais Santurio, Sydney Hartz Alves
The objective of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. against classic antifungals (amphotericin B [AMB], itraconazole [ITC], voriconazole [VRC] and caspofungin [CAS]) and to nonantifungal agents (amiodarone [AMD], doxycycline [DOX] and moxifloxacin [MXF]) using broth microdilution method. The combinations between these antifungal plus nonantifungal agents were also evaluated for the determination of FICI (fractional inhibitory concentration index) using the checkerboard technique...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29122715/nematicidal-activity-of-a-water-soluble-lectin-from-seeds-of-moringa-oleifera
#12
Mário Luan Silva de Medeiros, Maiara Celine de Moura, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Luana Cassandra Breitenbach Barroso Coelho, Ana Carla Diógenes Suassuna Bezerra, Michele Dalvina Correia da Silva
Gastrointestinal nematodes are the major cause of animal diseases, and the indiscriminate use of synthetic anthelmintic contributes to the development of drug resistance. Natural bioproducts are noteworthy since they have proved to be promising for alternative antiparasitic therapies. This study evaluated the in vitro effect of WSMoL (water soluble Moringa oleifera lectin) on hatching of eggs and on the development of early-stage larvae of gastrointestinal nematodes from naturally infected goats. In addition, the interference of WSMoL on activity of proteases was determined and the affinity of the lectin for glycosylated molecules of these parasites was investigated using fluorescein isothiocyanate (FITC)-labeled WSMoL...
November 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29122403/validation-of-simple-and-cost-effective-stains-to-assess-acrosomal-status-dna-damage-and-mitochondrial-activity-in-rooster-spermatozoa
#13
Bruno R Rui, Daniel S R Angrimani, João Diego A Losano, Luana de Cássia Bicudo, Marcílio Nichi, Ricardo J G Pereira
Several methods have been developed to evaluate spermatozoa function in birds but many of these are sometimes complicated, costly and not applicable to field studies (i.e., performed within poultry breeding facilities). The objective was, therefore, to validate efficient, practical and inexpensive procedures to determine DNA fragmentation, acrosomal integrity, and mitochondrial activity in poultry spermatozoa. Initially, ejaculates were individually diluted and divided into control (4°C, 4h) and UV-irradiated aliquots (room temperature, 4h), and then samples containing different percentages of DNA-damaged spermatozoa (0%, 25%, 50%, 75% and 100%) were subjected to Toluidine Blue (TB) and Sperm Chromatin Dispersion assessments (SCD)...
December 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29120861/preventing-relapse-to-smoking-with-transcranial-magnetic-stimulation-feasibility-and-potential-efficacy
#14
Christine E Sheffer, Warren K Bickel, Thomas H Brandon, Christopher T Franck, Darwin Deen, Luana Panissidi, Syed Amir Abdali, Jami C Pittman, Sara E Lunden, Neelam Prashad, Ria Malhotra, Antonio Mantovani
Many smokers attempt to quit every year, but 90% relapse within 12 months. Converging evidence suggests relapse is associated with insufficient activation of the prefrontal cortex. Delay discounting rate reflects relative activity in brain regions associated with relapse. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (LDLPFC) increases cortical excitability and reduces delay discounting rates, but little is known about feasibility, tolerability, and potential efficacy for smoking cessation...
November 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29119760/-tuberculosis-in-prato-tuscany-region-central-italy-in-the-period-2007-2014
#15
Irene Bellini, Sara Pugi, Carolina Degl'Innocenti, Annalisa Roselli, Davide Biagiotti, Luana Paliaga, Cristiana Berti, Vanna Margheri, Luigi Ricci, Antonino Nastasi
OBJECTIVES: a description of the epidemiology of tuberculosis in the province of Prato (Tuscany Region, Central Italy) during the period 2007-2014 and verify the latency time between the onset of symptoms and the start of therapy. DESIGN: descriptive, observational study. SETTING AND PARTICIPANTS: tuberculosis cases were identified for the period 2007-2014 through an analysis of the notification files available at the Hygiene and Public Health Service of the Local Health Unit of Prato and through the Information System on Infectious Diseases database...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29118715/differential-regulation-of-thyroid-hormone-metabolism-target-genes-during-non-thyoidal-illness-syndrome-triggered-by-fasting-or-sepsis-in-adult-mice
#16
Klaus N Fontes, Adriana Cabanelas, Flavia F Bloise, Cherley Borba Vieira de Andrade, Luana L Souza, Marianna Wilieman, Isis H Trevenzoli, Lais C Agra, Johnatas D Silva, Christianne Bandeira-Melo, Pedro L Silva, Patricia R M Rocco, Tania M Ortiga-Carvalho
Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the tissue level. Moreover, even though it has been considered the same syndrome, we hypothesized that fasting and sepsis induce a distinct set of changes in thyroid hormone metabolism. Herein, we aimed to evaluate the central and peripheral expression of genes involved in the transport (MCT8/Slc16a2 and MCT10/Slc16a10), metabolism (Dio1, Dio2, and Dio3) and action (Thra and Thrb) of TH during NTIS induced by fasting or sepsis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29113595/the-helminth-community-of-a-population-of-rattus-norvegicus-from-an-urban-brazilian-slum-and-the-threat-of-zoonotic-diseases
#17
Ticiana Carvalho-Pereira, Fábio N Souza, Luana R N Santos, Ruth Walker, Arsinoê C Pertile, Daiana S de Oliveira, Gabriel G Pedra, Amanda Minter, Maria Gorete Rodrigues, Thiago C Bahiense, Mitermayer G Reis, Peter J Diggle, Albert I Ko, James E Childs, Eduardo M da Silva, Mike Begon, Federico Costa
Urban slums provide suitable conditions for infestation by rats, which harbour and shed a wide diversity of zoonotic pathogens including helminths. We aimed to identify risk factors associated with the probability and intensity of infection of helminths of the digestive tract in an urban slum population of Rattus norvegicus. Among 299 rats, eleven species/groups of helminths were identified, of which Strongyloides sp., Nippostrongylus brasiliensis and, the human pathogen, Angiostrongylus cantonensis were the most frequent (97, 41 and 39%, respectively)...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29113311/the-anti-apoptotic-bag3-protein-is-involved-in-braf-inhibitor-resistance-in-melanoma-cells
#18
Luana Guerriero, Giuseppe Palmieri, Margot De Marco, Antonio Cossu, Paolo Remondelli, Mario Capunzo, Maria Caterina Turco, Alessandra Rosati
BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumour types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating crucial events such as apoptosis, differentiation, cell motility, and autophagy. In human melanomas, BAG3 positivity is correlated with the aggressiveness of the tumour cells and can sustain IKK-γ levels, allowing a sustained activation of NF-κB. Furthermore, BAG3 is able to modulate BRAFV600E levels and activity in thyroid carcinomas...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112328/low-power-laser-irradiation-decreases-lipid-droplet-accumulation-in-the-parotid-glands-of-diabetic-rats
#19
Juliana Rodrigues de Castro, Eugen Mendes Nesadal de Souza, Yun-Jong Park, Luana de Campos, Seunghee Cha, Victor Elias Arana-Chavez, José Nicolau, Alyne Simões
Lipid droplet accumulation has been related to salivary gland hypofunction in diabetes. In this study, the effect of laser irradiation on the parotid salivary glands (PG) of diabetic rats was analyzed with regard to its effect on lipid droplet accumulation, intracellular calcium concentration and calmodulin expression. The animals were distributed into 6 groups: D0, D5, D20 and C0, C5, C20, for diabetic (D) and control animals (C), respectively. Twenty-nine days following diabetes induction, PG of groups D5 and C5; D20 and C20 were irradiated with 5 and 20 J/cm(2) of a red diode laser at 100 mW, respectively...
November 7, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29111865/determination-of-pharmaceutical-compounds-in-hospital-wastewater-and-their-elimination-by-advanced-oxidation-processes
#20
Fernanda S Souza, Vanessa V Da Silva, Catiusa K Rosin, Luana Hainzenreder, Alexandre Arenzon, Tania Pizzolato, Louise Jank, Liliana A Féris
This study investigates the mineralization efficiency, i.e. removal of total organic carbon (TOC) in hospital wastewater by direct ozonation, ozonation with UV radiation (O3/UV), homogeneous catalytic ozonation (O3/Fe(2+)) and homogeneous photocatalytic ozonation (O3/Fe(2+)/UV). The influence of pH and reaction time was evaluated. For the best process, toxicity and degradation efficiency of the selected pharmaceutical compounds (PhCs) were determined. The results showed that the PhCs detected in the hospital wastewater were completely degraded when the mineralization efficiency reached 54...
November 7, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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