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Felipe P Andrade, Roberto Montoro, Renan Oliveira, Gabriela Loures, Luana Flessak, Roberta Gross, Camille Donnabella, Andrea Puchnick, Lisa Suzuki, Rodrigo Regacini
OBJECTIVES: 1) To verify clinical signs correlated with appropriate cranial computed tomography scan indications and changes in the therapeutic approach in pediatric minor head trauma scenarios. 2) To estimate the radiation exposure of computed tomography scans with low dose protocols in the context of trauma and the additional associated risk. METHODS: Investigators reviewed the medical records of all children with minor head trauma, which was defined as a Glasgow coma scale ≥13 at the time of admission to the emergency room, who underwent computed tomography scans during the years of 2013 and 2014...
October 1, 2016: Clinics
Enio Campos Amico, José Roberto Alves, Samir Assi João, Priscila Luana Franco Costa Guimarães, Joafran Alexandre Costa de Medeiros, Élio José Silveira da Silva Barreto
Background: Hepatectomies have been increasingly recommended and performed in Brazil; they present great differences related to immediate complications. Aim: Assessing the immediate postoperative complications in a series of 88 open liver resections. Method: Prospective database of patients subjected to consecutive hepatectomies over nine years. The post-hepatectomy complications were categorized according to the Clavien-Dindo classification; complications presenting grade equal to or greater than 3 were considered major complications...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnea (OSA) is characterized by repetitive interruptions of breathing, causing a Chronic Intermittent Hypoxia (CIH) that can be a key step in the development and progression of cardiovascular diseases. Nowadays, in fact, there is scientific evidence showing the close relationship between OSA and atherosclerosis, even in those patients who do not show co-morbidities such as hypertension, diabetes, high levels of low-density lipoprotein (LDL), cigarette smoking and obesity, which normally are able to activate the endothelium...
October 7, 2016: Current Vascular Pharmacology
Juliana Sorraila de Oliveira, Fátima Husein Abdalla, Guilherme Lopes Dornelles, Stephen Adeniyi Adefegha, Taís Vidal Palma, Cristiane Signor, Jamile da Silva Bernardi, Jucimara Baldissarelli, Luana Suéling Lenz, Luana Pereira Magni, Maribel Antonello Rubin, Micheli Mainardi Pillat, Cinthia Melazzo de Andrade
The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia. Sixty male Wistar rats were randomly divided into six groups: control (CTR), BRB 50mg/kg (BRB 50), BRB 100mg/kg (BRB 100), streptozotocin (STZ), streptozotocin plus BRB 50mg/kg (STZ+BRB 50), and streptozotocin plus BRB 100mg/kg (STZ+BRB 100)...
October 13, 2016: Neurotoxicology
Marina Borro, Andrea Botticelli, Federica Mazzuca, Elisa Concetta Onesti, Giovanna Gentile, Adriana Romiti, Bruna Cerbelli, Eva Mazzotti, Luca Marchetti, Luana Lionetto, Maurizio Simmaco, Paolo Marchetti
BACKGROUND: 5-fluorouracil (5-FU) based chemotherapy is the most common first line regimen used in gastric and gastroesophageal junction cancer, but development of severe toxicity is a main concern in the treatment. The present study is aimed to evaluate a novel pre-treatment assay, known as the 5-FU degradation rate (5-FUDR), as a predictive factor for 5-FU toxicity. METHODS: Pre-treatment 5-FUDR and gene polymorphisms related to 5-FU metabolism (DPYDIVS14+1G>A, MTHFRA1298T or C677T, TMYS TSER) were characterized in gastro-esophageal cancer patients...
October 11, 2016: Oncotarget
Glauco Adrieno Westphal, Valter Duro Garcia, Rafael Lisboa de Souza, Cristiano Augusto Franke, Kalinca Daberkow Vieira, Viviane Renata Zaclikevis Birckholz, Miriam Cristine Machado, Eliana Régia Barbosa de Almeida, Fernando Osni Machado, Luiz Antônio da Costa Sardinha, Raquel Wanzuita, Carlos Eduardo Soares Silvado, Gerson Costa, Vera Braatz, Milton Caldeira Filho, Rodrigo Furtado, Luana Alves Tannous, André Gustavo Neves de Albuquerque, Edson Abdala
Organ transplantation is the only alternative for many patients with terminal diseases. The increasing disproportion between the high demand for organ transplants and the low rate of transplants actually performed is worrisome. Some of the causes of this disproportion are errors in the identification of potential organ donors and in the determination of contraindications by the attending staff. Therefore, the aim of the present document is to provide guidelines for intensive care multi-professional staffs for the recognition, assessment and acceptance of potential organ donors...
September 2016: Revista Brasileira de Terapia Intensiva
Luana Soriano Mota, Claudia Maria Costa de Oliveira, Francisco Martho Leal Pinheiro, Larissa Costa de Oliveira Santos, Danilo Gonçalves Nóbrega, Paula Fbc Fernandes, Alda Angélica de Melo Costa, Sônia Leite da Silva
Introduction: Kidney transplants with expanded criteria donor have been associated with improved patient survival compared to those who remain on dialysis. Objective: To compare renal function and survival of the kidney graft of deceased donor with expanded criteria and standard criteria over a year in a single transplant center. Methods: 255 kidney transplant recipients with deceased donor were included in the study between the years 2011 to 2013 and they were separated into two groups according to the type of donor (expanded criteria donor - ECD - and standard criteria donor - SCD)...
July 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Cinzia Pagano, Maria Cristina Tiralti, Luana Perioli
OBJECTIVES: Folic acid (FA) is an important source for the prevention of many diseases. However, its use is limited because the very low solubility (<10 mg/l particularly in the gastric environment) responsible for the incomplete adsorption of the administered dose. This study proposes a technological strategy to overcome this problem enhancing FA dissolution rate by means of a formulation able to make completely bioavailable the whole administered dose. METHODS: Folic acid was intercalated in the layered double hydroxides (LDHs) MgAl-LDH and ZnAl-LDH...
October 13, 2016: Journal of Pharmacy and Pharmacology
Gabriel Feresin Pantalião, Marcelo Narciso, Cléber Guimarães, Adriano Castro, José Manoel Colombari, Flavio Breseghello, Luana Rodrigues, Rosana Pereira Vianello, Tereza Oliveira Borba, Claudio Brondani
The identification of rice drought tolerant materials is crucial for the development of best performing cultivars for the upland cultivation system. This study aimed to identify markers and candidate genes associated with drought tolerance by Genome Wide Association Study analysis, in order to develop tools for use in rice breeding programs. This analysis was made with 175 upland rice accessions (Oryza sativa), evaluated in experiments with and without water restriction, and 150,325 SNPs. Thirteen SNP markers associated with yield under drought conditions were identified...
October 8, 2016: Genetica
Massimo Vaia, Stefania Petrosino, Daniele De Filippis, Luana Negro, Andrea Guarino, Rosa Carnuccio, Vincenzo Di Marzo, Teresa Iuvone
In mice, 2,4-dinitrofluorobenzene (DNFB) induces contact allergic dermatitis (CAD), which, in a late phase, is characterized by mast cell (MC) infiltration and angiogenesis. Palmitoylethanolamide (PEA), an endogenous anti-inflammatory molecule, acts by down-modulating MCs following activation of the cannabinoid CB2 receptor and peroxisome proliferator-activated receptor-α (PPAR-α). We have previously reported the anti-inflammatory effect of PEA in the early stage of CAD. Here, we examined whether PEA reduces the features of the late stage of CAD including MC activation, angiogenesis and itching...
October 5, 2016: European Journal of Pharmacology
Hamdi Bendif, Messaoud Boudjeniba, Mohamed Djamel Miara, Loreta Biqiku, Massimo Bramucci, Giovanni Caprioli, Giulio Lupidi, Luana Quassinti, Gianni Sagratini, Luca A Vitali, Sauro Vittori, Filippo Maggi
Rosmarinus eriocalyx is an aromatic evergreen bush endemic to Algeria where it is used as a condiment to flavour soups and meat and as a traditional remedy. In the present work we have analyzed for the first time the phenolic composition of polar extracts obtained from stems, leaves and flowers of R. eriocalyx by HPLC, and determined the antioxidant and antimicrobial effects by DPPH, ABTS, FRAP, ORAC and agar disc diffusion methods, respectively. Results showed that ethanolic extracts of leaves and flowers are a rich source of phenolic compounds, mainly rosmarinic acid, carnosic acid and carnosol that are the main responsible for the noteworthy antioxidant activity observed in the assays...
March 1, 2017: Food Chemistry
Luana Sicuro Correa, Yara Hahr Marques Hökerberg, Raquel de Vasconcellos Carvalhaes de Oliveira, Danielle Martins de Souza Barros, Helenara Abadia Ferreira Alexandria, Regina Paiva Daumas, Carlos Augusto Ferreira de Andrade, Sonia Regina Lambert Passos, Patrícia Brasil
OBJECTIVE: The aim of this study was to describe the use of dengue warning signs by pediatric healthcare staff in the Brazilian public health care system. METHODS: Cross-sectional study (2012) with physicians, nurses, and nurse technicians assisting children in five health care facilities. Participants reported the use and importance of dengue warning signs in pediatrics clinical practice through a structured questionnaire. Differences in the use of signs (chi-square test) and in the ranking assigned to each of them (Kruskal-Wallis) were assessed according to health care occupation and level of care (p<0...
2016: PloS One
Janaina Melo, Adriana Moreno, Virginia Ferriani, Ana Carla Araujo, Elcio Vianna, Marcos Borges, Pérsio Roxo, Marcos Gonçalves, Luane Mello, Rosa Parreira, Jorgete Silva, Patricia Stefanelli, Larissa Panazolo, Andrea Cetlin, Luana Queiroz, Rosângela Araujo, Marina Dias, Davi Aragon, Nélio Domingos, L Karla Arruda
OBJECTIVE: Asthma is under-diagnosed in many parts of the world. We aimed to assess the outcome of a capacitating program on asthma for non-specialist physicians and other healthcare professionals working in the public health system in Ribeirão Preto, Brazil. METHODS: A group of 16 asthma specialists developed a one-year capacitating program in 11 healthcare clinics in the Northern District of the city, which included lectures on asthma, training on inhalation device use and spirometry, and development of an asthma management protocol...
October 7, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Massimiliano Godani, Marco Zoccarato, Alessandro Beronio, Luigi Zuliani, Luana Benedetti, Bruno Giometto, Massimo Del Sette, Elisa Raggio, Roberta Baldi, Angela Vincent
BACKGROUND: The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. OBJECTIVE: The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND)...
October 7, 2016: Neuro-degenerative Diseases
Fernando Ezquerro, Adriano H Moffa, Marom Bikson, Niranjan Khadka, Luana V M Aparicio, Bernardo de Sampaio-Junior, Felipe Fregni, Isabela M Bensenor, Paulo A Lotufo, Alexandre Costa Pereira, Andre R Brunoni
OBJECTIVE: To evaluate whether and to which extent skin redness (erythema) affects investigator blinding in transcranial direct current stimulation (tDCS) trials. MATERIAL AND METHODS: Twenty-six volunteers received sham and active tDCS, which was applied with saline-soaked sponges of different thicknesses. High-resolution skin images, taken before and 5, 15, and 30 min after stimulation, were randomized and presented to experienced raters who evaluated erythema intensity and judged on the likelihood of stimulation condition (sham vs...
October 5, 2016: Neuromodulation: Journal of the International Neuromodulation Society
Luana Dos S Souza, Carmen Simioni, Zenilda L Bouzon, Rosana de Cassia da S Schneider, Pablo Gressler, Maria Cecília Miotto, Marcio J Rossi, Leonardo R Rörig
Chlamydomonas acidophila LAFIC-004 is an acidophilic strain of green microalgae isolated from coal mining drainage. In the present work, this strain was cultivated in acidic medium (pH 3.6) under phototrophic, mixotrophic, and heterotrophic regimes to determine the best condition for growth and lipid production, simultaneously assessing possible morphological and ultrastructural alterations in the cells. For heterotrophic and mixotrophic treatments, two organic carbon sources were tested: 1 % glucose and 1 % sodium acetate...
September 30, 2016: Protoplasma
Cássia R A da Cunha, Luís C N da Silva, Fábio J F Almeida, Milena S Ferraz, Nathalia Varejão, Marina F de Souza Cartaxo, Rita de Cássia M de Miranda, Francisco C A de Aguiar, Noemia P da Silva Santos, Luana C B B Coelho, Nereide S Santos-Magalhães, Maria T Dos Santos Correia
This study evaluated the in vivo antitumor potential of the recombinant lectin from seeds of Cratylia mollis (rCramoll) expressed in Escherichia coli, free or encapsulated in stealth liposomes, using mice transplanted with sarcoma 180. rCramoll-loaded stealth liposomes (rCramoll-lipo) were formulated by hydration of the lipid film followed by cycles of freezing and thawing, and about 60% of rCramoll was encapsulated. This novel preparation showed particle size, polydispersity index, and pH suitable for the evaluation of antitumor activity in vivo...
2016: Frontiers in Microbiology
Luana G M Ferrara, Gregor D Wallat, Lucile Moynié, Naresh N Dhanasekar, Soumeya Aliouane, Silvia Acosta-Gutiérrez, Jean-Marie Pagès, Jean-Michel Bolla, Mathias Winterhalter, Matteo Ceccarelli, James H Naismith
The Gram-negative organism Campylobacter jejuni is the major cause of food poisoning. Unlike Escherichia coli, which has two major porins, OmpC and OmpF, C. jejuni has one, termed major outer membrane protein (MOMP) through which nutrients and antibiotics transit. We report the 2.1-Å crystal structure of C. jejuni MOMP expressed in E. coli and a lower resolution but otherwise identical structure purified directly from C. jejuni. The 2.1-Å resolution structure of recombinant MOMP showed that although the protein has timeric arrangement similar to OmpC, it is an 18-stranded, not 16-stranded, β-barrel...
September 30, 2016: Journal of Molecular Biology
Hamdi Bendif, Messaoud Boudjeniba, Mohamed Djamel Miara, Loreta Biqiku, Massimo Bramucci, Giulio Lupidi, Luana Quassinti, Luca A Vitali, Filippo Maggi
Thymus munbyanus subsp. coloratus (Lamiaceae) is a small shrub endemic to Algeria and Morocco where is found in lawns, rockeries and mountainous regions. From a phytochemical point of view this taxon has never been characterized. In this work we have analysed the chemical compositions of the essential oils obtained from inflorescences and vegetative parts by GC-MS. A new chemotype, i.e. borneol-chemotype, was characterized for the first time in the species. Furthermore, we assessed the biological activities of essential oils, namely the antioxidant, antimicrobial and cytotoxicity on tumor cells that were evaluated by the DPPH, ABTS and FRAP, disc diffusion, and MTT methods, respectively...
September 29, 2016: Chemistry & Biodiversity
Luana Goés Soares, Igor Reali Costa, Jadimar Dos Santos Brum Júnior, Wyllerson Silveira Bronzon Cerqueira, Evandro Silveira de Oliveira, Dhelfeson Willya Douglas de Oliveira, Patricia Furtado Gonçalves, José Cristiano Ramos Glória, Karine Tais Aguiar Tavano, Olga Dumont Flecha
OBJECTIVE: The aim of this study was to determine the prevalence of bruxism in students at the Federal University of the Jequitinhonha and Mucuri Valleys in Brazil. The secondary objectives were to identify the factors associated with bruxism; prevalence of dental wear; and to distinguish the signs and symptoms of temporomandibular dysfunction when present, and verify its relationship with bruxism. METHODS: Two hundred fifty-three students (106 males, 147 females) were clinically examined and answered a questionnaire...
August 12, 2016: Cranio: the Journal of Craniomandibular Practice
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