keyword
MENU ▼
Read by QxMD icon Read
search

Microvesicles

keyword
https://www.readbyqxmd.com/read/28714557/concise-review-developing-best-practice-models-for-the-therapeutic-use-of-extracellular-vesicles
#1
REVIEW
Agnes T Reiner, Kenneth W Witwer, Bas W M van Balkom, Joel de Beer, Chaya Brodie, Randolph L Corteling, Susanne Gabrielsson, Mario Gimona, Ahmed G Ibrahim, Dominique de Kleijn, Charles P Lai, Jan Lötvall, Hernando A Del Portillo, Ilona G Reischl, Milad Riazifar, Carlos Salomon, Hidetoshi Tahara, Wei Seong Toh, Marca H M Wauben, Vicky K Yang, Yijun Yang, Ronne Wee Yeh Yeo, Hang Yin, Bernd Giebel, Eva Rohde, Sai Kiang Lim
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels...
July 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28713160/pathogenic-roles-of-microvesicles-in-diabetic-retinopathy
#2
REVIEW
Wei Zhang, Song Chen, Ming-Lin Liu
Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation...
July 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28710089/endothelium-neutrophil-communication-via-b1-kinin-receptor-bearing-microvesicles-in-vasculitis
#3
EDITORIAL
Pierre-Louis Tharaux, Neeraj Dhaun
No abstract text is available yet for this article.
July 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28706266/microenvironmental-regulation-of-tumour-angiogenesis
#4
REVIEW
Michele De Palma, Daniela Biziato, Tatiana V Petrova
Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles. In this Review, we discuss the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies...
July 14, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28701751/secretome-of-in-vitro-cultured-human-embryos-contains-extracellular-vesicles-that-are-uptaken-by-the-maternal-side
#5
Elisa Giacomini, Riccardo Vago, Ana Maria Sanchez, Paola Podini, Natasa Zarovni, Valentina Murdica, Roberta Rizzo, Daria Bortolotti, Massimo Candiani, Paola Viganò
Communication between embryo and maternal endometrium occurs during a specific time frame in which implantation is possible. Here we demonstrate for the first time that conditioned media from non-manipulated human embryos cultured in vitro for 3 days or up to the blastocyst stage contain extracellular vesicles (EVs) with a diameter of 50 to 200 nm and bearing the traditional microvesicle and exosome marker proteins CD63, CD9 and ALIX. The embryonic origin of these EVs has been confirmed by the presence of stemness gene transcripts and their enrichment in the non-classical HLA-G protein...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700020/a-meta-analysis-of-circulating-microvesicles-in-patients-with-myocardial-infarction
#6
Zhida Wang, Wang Cai, Shaolan Hu, Yufei Xia, Yao Wang, Qi Zhang, Liming Chen
Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study...
July 10, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28697439/targeting-dendritic-cells-for-the-treatment-of-autoimmune-disorders
#7
REVIEW
C Sousa, I Pereira, A C Santos, C Carbone, A B Kovačević, A M Silva, E B Souto
In the last decades, it has been recognized that extracellular vesicles (EVs) are not only cell debris with no biological role, but instead they play a key role in information exchange between cells either in health and disease conditions. EVs exhibit indeed their biological role in a pleiotropic manner. They can modulate immune responses through the activation, transfer or removal of surface receptors on target cells, the removal of cytolytic components such as membrane attack complexes, and the transfer of signaling molecules/effectors, such as nucleic acid species, infectious particles, and oncogenes...
June 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28690205/bronchoalveolar-lavage-microvesicles-protect-burn-injured-mice-from-pulmonary-infection
#8
Teresa C Rice, Amanda M Pugh, Brent T Xia, Aaron P Seitz, Brynne E Whitacre, Erich Gulbins, Charles C Caldwell
BACKGROUND: Pseudomonas aeruginosa (PA) is a major cause of morbidity and mortality among burn patients, despite antibiotic therapy. There is a need to identify innate immune defenses that prevent PA infection in injured adults in an effort to find therapeutic alternatives to antibiotics. Here, we tested our hypothesis that Microvesicles (MVs) in bronchoalveolar (BAL) fluid have a role in the immunity of the lung in response to pathogens. STUDY DESIGN: MVs were isolated from murine BAL fluid, quantified using nanoparticle tracking analysis, and injected into burn injured mice prior to PA infection...
July 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28687495/extracellular-vesicles-novel-promising-delivery-systems-for-therapy-of-brain-diseases
#9
REVIEW
David Rufino-Ramos, Patrícia R Albuquerque, Vitor Carmona, Rita Perfeito, Rui Jorge Nobre, Luis Pereira de Almeida
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all cells, including brain cells. EVs are a major term that includes apoptotic bodies, microvesicles and exosomes. The release of EVs has been recognized as an important modulator in cross-talking between neurons, astrocytes, microglia and oligodendrocytes, not only in central nervous system (CNS) physiology but also in neurodegenerative and neuroinflammatory disease states as well as in brain tumors, such as glioma. EVs are able to cross the blood brain barrier (BBB), spread to body fluids and reach distant tissues...
July 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28684664/mesenchymal-stem-stromal-cell-derived-extracellular-vesicles-and-their-potential-as-novel-immunomodulatory-therapeutic-agents
#10
REVIEW
Verena Börger, Michel Bremer, Rita Ferrer-Tur, Lena Gockeln, Oumaima Stambouli, Amina Becic, Bernd Giebel
Extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as mediators of a newly-discovered intercellular communication system. They are essential signaling mediators in various physiological and pathophysiological processes. Depending on their origin, they fulfill different functions. EVs of mesenchymal stem/stromal cells (MSCs) have been found to promote comparable therapeutic activities as MSCs themselves. In a variety of in vivo models, it has been observed that they suppress pro-inflammatory processes and reduce oxidative stress and fibrosis...
July 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28684402/braf-v600-inhibition-alters-the-microrna-cargo-in-the-vesicular-secretome-of-malignant-melanoma-cells
#11
Taral R Lunavat, Lesley Cheng, Berglind O Einarsdottir, Roger Olofsson Bagge, Somsundar Veppil Muralidharan, Robyn A Sharples, Cecilia Lässer, Yong Song Gho, Andrew F Hill, Jonas A Nilsson, Jan Lötvall
The BRAF inhibitors vemurafenib and dabrafenib can be used to treat patients with metastatic melanomas harboring BRAF(V600) mutations. Initial antitumoral responses are often seen, but drug-resistant clones with reactivation of the MEK-ERK pathway soon appear. Recently, the secretome of tumor-derived extracellular vesicles (EVs) has been ascribed important functions in cancers. To elucidate the possible functions of EVs in BRAF-mutant melanoma, we determined the RNA content of the EVs, including apoptotic bodies, microvesicles, and exosomes, released from such cancer cells after vemurafenib treatment...
July 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28684288/extracellular-vesicles-in-lung-disease
#12
REVIEW
Hiroshi Kubo
Accumulating evidence suggests that extracellular vesicles play a role in pathogenesis of lung diseases. The vesicles include exosomes, ectosomes (a.k.a. microparticles, extracellular vesicles, microvesicles, and shedding vesicles), and apoptotic bodies. Exosomes are generated by inward budding of the membrane (endocytosis), subsequent forming multivesicular bodies, and releasing by exocytosis. Ectosomes are formed by outward blebbing from the plasma membrane and then released by proteolytic cleavage from the cell surface...
July 3, 2017: Chest
https://www.readbyqxmd.com/read/28678586/extracellular-vesicle-biology-in-the-pathogenesis-of-lung-disease
#13
Serge P Nana-Sinkam, Mario Acunzo, Carlo M Croce, Kai Wang
As our understanding of diseases of the lung continues to evolve, we recognize that the mechanisms that drive cell/environment communication leading to disease development and progression are complex. In 2008, investigators first identified intact cell free microRNAs in circulation with some localized within lipid-encapsulated microvesicles termed extracellular vesicles (EVs). Prior to and following this discovery, investigators have determined that EVs may drive biological processes fundamental to human disease and homeostasis...
July 5, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28676332/circulating-exosomes-in-obstructive-sleep-apnea-as-phenotypic-biomarkers-and-mechanistic-messengers-of-end-organ-morbidity
#14
REVIEW
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, David Gozal
Obstructive sleep apnea (OSA), the most severe form of sleep disordered breathing, is characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic hypercapnia. OSA is associated with increased risk for morbidity and mortality affecting cardiovascular, metabolic, and neurocognitive systems, and more recently with non-alcoholic fatty liver disease (NAFLD) and cancer-related deaths. Substantial variability in OSA outcomes suggests that genetically-determined and environmental and lifestyle factors affect the phenotypic susceptibility to OSA...
July 1, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28674887/simultaneous-enrichment-of-plasma-extracellular-vesicles-and-glycoproteome-for-studying-disease-biomarkers
#15
Sunil S Adav, Siu Kwan Sze
To detect disease at an early stage and to develop effective disease treatment therapies, reliable biomarkers of diagnosis, disease progression, and its status remain a research priority. A majority of disease pathologies are primarily associated with different subsets of cells of different tissues, discrete compartments, and areas. These subsets of cells release glycoproteins and specific extracellular vesicles (EVs) including microvesicles and exosomes that carry bioactive cargoes of proteins, nucleic acids, and metabolites...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28674181/lung-epithelial-cell-derived-microvesicles-regulate-macrophage-migration-via-microrna-17-221-induced-integrin-%C3%AE-1-recycling
#16
Heedoo Lee, Duo Zhang, Jingxuan Wu, Leo E Otterbein, Yang Jin
Robust lung inflammation is one of the prominent features in the pathogenesis of acute lung injury (ALI). Macrophage migration and recruitment are often seen at the early stage of lung inflammatory responses to noxious stimuli. Using an acid inhalation-induced lung injury model, we explored the mechanisms by which acid exposure initiates macrophage recruitment and migration during development of ALI. The lung epithelium comprises a large surface area and functions as a first-line defense against noxious insults...
July 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28673066/extracellular-vesicles-as-a-source-of-urological-biomarkers-lessons-learned-from-advances-and-challenges-in-clinical-applications-to-major-diseases
#17
REVIEW
Ji-Young Choi, Sujin Kim, Hyo-Bum Kwak, Dong-Ho Park, Jae-Hyoung Park, Jeong-Seon Ryu, Chang-Shin Park, Ju-Hee Kang
Extracellular vesicles (EVs) not only eliminate unwanted molecular components, but also carry molecular cargo essential for specific intercellular communication mechanisms. As the molecular characteristics and biogenetical mechanisms of heterogeneous EVs are different, many studies have attempted to purify and characterize EVs. In particular, exosomal molecules, including proteins, lipids, and nucleic acids, have been suggested as disease biomarkers or therapeutic targets in various diseases. However, several unresolved issues and challenges remain despite these promising results, including source variability before the isolation of exosomes from body fluids, the contamination of proteins during isolation, and methodological issues related to the purification of exosomes...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28670703/tgf-%C3%AE-induced-par-1-expression-promotes-tumor-progression-and-osteoclast-differentiation-in-giant-cell-tumor-of-bone
#18
Ting Wang, Jian Jiao, Hao Zhang, Wang Zhou, Zhenxi Li, Shuai Han, Jing Wang, Xinghai Yang, Quan Huang, Zhipeng Wu, Wangjun Yan, Jianru Xiao
Although protease activated receptor-1 (PAR-1) has been confirmed as an oncogene in many cancers, the role of PAR-1 in giant cell tumor (GCT) of bone has been rarely reported. The mechanism of PAR-1 in tumor-induced osteoclastogenesis still remains unclear. In the present study, we detected that PAR-1 was significantly upregulated in GCT of bone compared to normal tissues, while TGF-β was also overexpressed in GCT tissues and could promote the expression of PAR-1 in a dose and time dependent manner. By using the luciferase reporter assay, we found that two downstreams of TGF-β, Smad3 and Smad4, could activate the promoter of PAR-1, which might explain the mechanism of TGF-β induced PAR-1 expression...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28669749/extracellular-vesicles-in-gastrointestinal-cancer-in-conjunction-with-microbiota-on-the-border-of-kingdoms
#19
REVIEW
Natasha S Barteneva, Yeldar Baiken, Elizaveta Fasler-Kan, Kenneth Alibek, Sheng Wang, Natalia Maltsev, Eugeny D Ponomarev, Zarina Sautbayeva, Sholpan Kauanova, Anna Moore, Christoph Beglinger, Ivan A Vorobjev
Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicls). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28668562/origin-and-characterization-of-small-membranous-vesicles-present-in-the-venom-of-crotalus-durissus-terrificus
#20
Andréia Souza-Imberg, Sylvia Mendes Carneiro, Karina Cristina Giannotti, Sávio Stefanini Sant'Anna, Norma Yamanouye
Small membranous vesicles are small closed fragments of membrane. They are released from multivesicular bodies (exosomes) or shed from the surface membrane (microvesicles). They contains various bioactive molecules and their molecular composition varies depending on their cellular origin. Small membranous vesicles have been identified in snake venoms, but the origin of these small membranous vesicles in the venom is controversial. The aim of this study was to verify the origin of the small membranous vesicles in venom of Crotalus durissus terrificus by morphological analyses using electron microscopy...
June 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
keyword
keyword
27454
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"