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Regional anticoagulation

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https://www.readbyqxmd.com/read/28898469/establishing-a-regional-paediatric-registry-improved-the-overview-and-detection-of-side-effects-in-children-on-anticoagulants
#1
Ida Jeremiasen, Katarina Hanséus, Pernilla Naumann, Camilla Nilsson, Ulf Tedgård, Peter J Svensson, Nadine G Andersson
The use of oral anticoagulants is rarer in children than adults, but studies indicate that their paediatric use is increasing (1). Warfarin has been used in children, at the discretion of the treating physician, but both the number of children and the data on its use are limited (2). There is also a lack of experience on the use of new oral anticoagulants for children. This article is protected by copyright. All rights reserved.
September 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28891256/composition-and-variation-analysis-of-the-tcr-%C3%AE-chain-cdr3-repertoire-in-neonatal-sepsis
#2
Jinqiao Sun, Bijun Sun, Yanyan Gao, Fusheng He, Lin Yang, Mingbang Wang, Wenhao Zhou
T cell receptor (TCR) diversity is clearly related to protection from infection. However, the characteristics of TCR diversity in neonates are not clear. In this study, we investigated the TCR diversity of neonates with sepsis. Twenty neonates with severe sepsis and 8 matched neonates without infection were enrolled in the study. For the neonates with sepsis, EDTA-anticoagulated blood was collected on day 1 after the diagnosis of sepsis and on day 7 of treatment. For the neonates without infection, blood was collected one time...
September 11, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28884671/detection-of-fungal-pathogens-by-a-new-broad-range-real-time-pcr-assay-targeting-the-fungal-its2-region
#3
Iris Zeller, Claudia Schabereiter-Gurtner, Verena Mihalits, Brigitte Selitsch, Wolfgang Barousch, Alexander M Hirschl, Athanasios Makristathis, Birgit Willinger
PURPOSE: The rise in the incidence of fungal infections and the expanding spectrum of fungal pathogens make early and broad detection of fungal pathogens essential. In the present study, a panfungal real-time PCR assay for the broad-range detection of fungal DNA (Fungi assay) in a wide variety of clinical specimens was developed. METHODOLOGY: Our in-house, HybProbe real-time PCR assay targets the ITS2 region of fungal DNA. The applicability was evaluated by testing 105 clinical samples from 98 patients with suspected fungal infection...
September 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28883793/a-multilevel-analysis-of-real-world-variations-in-oral-anticoagulation-initiation-for-atrial-fibrillation-in-valencia-a-european-region
#4
Aníbal García-Sempere, Daniel Bejarano-Quisoboni, Julián Librero, Clara L Rodríguez-Bernal, Salvador Peiró, Gabriel Sanfélix-Gimeno
Introduction: Beyond clinical trials, clinical practice guidelines, and administrative regulation, treatment decision-making can be influenced by individual and contextual factors. Our goal was to describe variations in the patterns of initiation of anticoagulation therapy in patients with atrial fibrillation by Health Areas (HA) in the region of Valencia in Spain and to quantify the influence of the HAs on variations in treatment choice. Methods: We conducted a population-based retrospective cohort study of all atrial fibrillation patients who started treatment with oral anticoagulants between November 2011 and February 2014 in each of the region's 24 HAs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28882608/-intracranial-hemorrhage-and-oral-anticoagulants-of-patients-treated-between-2011-and-2013-at-the-nancy-regional-university-hospital
#5
A Leblanc, N Petitpain, O Pereira, H El Adssi, C Latarche, P Gillet, S Colnat-Coulbois
OBJECTIVE: To perform a descriptive analysis of intracranial hemorrhages of patients treated with an antivitamin K (fluindione, acenocoumarol or warfarin) or a direct oral anticoagulant (dabigatran, rivaroxaban or apixaban) at the Nancy Regional University Hospital. MATERIAL AND METHOD: The study period was from January 2011 to December 2013 and the computerized data (Programme de Médicalisation des Systèmes d'Information) of our hospital was accessed to identify the patients...
September 4, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28871391/hemofiltration-induces-generation-of-leukocyte-derived-cd31-cd41-microvesicles-in-sepsis
#6
Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann, Michael Joannidis
BACKGROUND: Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and possibly also eliminates inflammatory mediators in the setting of sepsis. On the other hand, proinflammatory stimuli are induced by blood contacting the artificial membrane during extracorporeal blood purification. In chronic dialysis patients a systemic increase in MV has been described...
September 4, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28871041/vena-cava-filter-retrieval-rates-and-factors-associated-with-retrieval-in-a-large-us-cohort
#7
Joshua D Brown, Driss Raissi, Qiong Han, Val R Adams, Jeffery C Talbert
BACKGROUND: Retrieval of vena cava filters (VCFs) is important for safety as complications increase with longer dwell times. This study assessed VCF retrieval rates and factors associated with retrieval in a national cohort. METHODS AND RESULTS: VCFs were identified by procedural codes from an administrative claims database. Patients were identified who had a VCF placement during a hospitalization from a national commercial administrative claims database. Indications for VCF placement were identified as pulmonary embolism with or without deep vein thrombosis, deep vein thrombosis only, or prophylactic...
September 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28867752/genotyping-of-cyp2c9-and-vkorc1-polymorphisms-predicts-south-indian-patients-with-deep-vein-thrombosis-as-fast-metabolizers-of-warfarin-acenocoumarin
#8
Ganesan Arunkumar, Durairajpandian Vishnuprabu, Bitt Nupur, Thiruvengadam Vidyasagaran, Avaniyapuram Kannan Murugan, Arasambattu Kannan Munirajan
Deep vein thrombosis (DVT) is a life-threatening disease. Warfarin and acenocoumarol are anticoagulants used to treat DVT and vary among individuals in terms of treatment response/toxicity. Single nucleotide polymorphisms (SNPs) in CYP2C9 and VKORC1 play a role in the pharmacokinetics and dynamics of warfarin and acenocoumarol and they determine the efficacy of treatment by controlling drug clearance in treated individuals. The aim of the current study was to genotype the critical SNPs of CYP2C9 and VKORC1 genes in a south Indian population in order to understand the metabolizer phenotype of patients with DVT...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28862718/clinical-impact-of-regional-citrate-anticoagulation-in-continuous-renal-replacement-therapy-in-critically-ill-patients
#9
Maria Huguet, Lida Rodas, Miquel Blasco, Luis F Quintana, Jordi Mercadal, Jose T Ortiz-Pérez, Irene Rovira, Esteban Poch
BACKGROUND: Regional citrate anticoagulation (RCA) is being used increasingly in continuous renal replacement therapy (CRRT) as a safer alternative to heparin. However, complex metabolic control to avoid side effects have generated discrepancies about its introduction into everyday practice. We aimed to compare both anticoagulation techniques in terms of efficacy, safety and feasibility. METHODS: Observational retrospective study performed in 3 specialized ICUs in patients receiving CVVHDF with RCA between January 2013 and May 2016...
August 17, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28859022/embolic-stroke-of-undetermined-source-in-latin-america-a-review
#10
Carlos Cantú-Brito, Gisele Sampaio Silva, Sebastián F Ameriso
BACKGROUND: Stroke is a major health concern throughout Latin America. As elsewhere, no precise cause can be determined for a substantial portion of strokes. In 6 studies since 2010 in the region, 16% to 43% of ischemic strokes were identified as cryptogenic. The term embolic stroke of undetermined source (ESUS) has been proposed as more clinically useful and positively defined than the vague term cryptogenic. The epidemiology of ESUS in Latin America is largely unknown. REVIEW SUMMARY: This article aims to provide a description of the epidemiology of ESUS in Latin America and practical information regarding available diagnostic procedures and current guidelines...
September 2017: Neurologist
https://www.readbyqxmd.com/read/28857854/heparin-free-prolonged-intermittent-hemodialysis-using-calcium-free-citrate-dialysate-in-critically-ill-patients
#11
Stanislas Faguer, Morgane Saint-Cricq, Marie-Béatrice Nogier, Isabelle Labadens, Laurence Lavayssiere, Nassim Kamar, Olivier Cointault
OBJECTIVES: Critically ill patients who have a high risk of bleeding but require prolonged intermittent dialysis need a heparin-free easy-to-use alternative type of anticoagulation within the dialysis circuit. We assessed the safety and efficiency of heparin-free regional citrate anticoagulation of the dialysis circuit using a calcium-free citrate-containing dialysate, with calcium reinjected according to ionic dialysance. DESIGN: Prospective cohort study. SETTING: Critical care units...
August 28, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28855941/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-affine-hydroalcoholic-extract
#12
Masoud Sadeghi, Leila Safaeian, Mohammadreza Aghaye Ghazvini, Mojtaba Ramezani
Allium affine is a member of Amaryllidaceae family, which grows wildly in some western regions of Iran. Limited information is available about the pharmacological activities of this plant. The present study aimed to evaluate the fibrinolytic and antioxidant effects of hydroalcoholic extract of A. affine aerial parts. The in vitro antioxidant properties of the extract were evaluated by total phenolic content assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assay...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28831085/percutaneous-closure-of-left-atrial-appendage-affects-mid-term-release-of-mr-proanp
#13
Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Ursula Hoffmann, Christian Fastner, Martin Borggrefe, Thomas Roth, Jakob Triebel, Thomas Bertsch, Ibrahim Akin
The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindication for oral anticoagulant therapy were enrolled. Blood samples were taken within 24 hours before (T1) and at least 6 months (mid-term) (T2) after successful implantation of LAA occlusion devices. Blood levels of high sensitivity troponin I and T (hsTnI, hsTnT), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) were evaluated at both time points...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818408/serial-assessment-of-natriuretic-peptides-in-patients-undergoing-interventional-closure-of-the-left-atrial-appendage
#14
Blerim Luani, Thomas Rauwolf, Thomas Groscheck, Ivan Tanev, Joerg Herold, Berend Isermann, Alexander Schmeisser, Rüdiger C Braun-Dullaeus
BACKGROUND: Closure of the left atrial appendage (LAA) to prevent cardioembolic events is an alternative therapy to oral anticoagulation in patients with non-valvular atrial fibrillation. The LAA is an important source of natriuretic peptides and its exclusion from the circulation may alter the blood level of these hormones, thereby influencing their diagnostic value and clinical effects. METHODS: We aimed to prospectively assess potential changes in mid-regional pro A-type natriuretic peptide (MR-proANP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels six weeks and six months after interventional LAA closure using the Watchman device...
August 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28818318/sex-and-gender-differences-in-thromboprophylactic-treatment-of-patients-with-atrial-fibrillation-after-the-introduction-of-non-vitamin-k-oral-anticoagulants
#15
Desirée Loikas, Tomas Forslund, Björn Wettermark, Karin Schenck-Gustafsson, Paul Hjemdahl, Mia von Euler
To examine sex differences in thromboprophylaxis in patients with atrial fibrillation before and after the introduction of non-vitamin K oral anticoagulants, we performed a cross-sectional registry study based on anonymized individual-level patient data of all individuals with a diagnosis of nonvalvular atrial fibrillation (International Classification of Diseases, Tenth Revision code I48) in the region of Stockholm, Sweden (2.2 million inhabitants), in 2011 and 2015, respectively. Thromboprophylaxis improved considerably during the period...
July 21, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28811393/analysis-of-geographical-variations-in-the-epidemiology-and-management-of-non-valvular-atrial-fibrillation-results-from-the-ramses-registry
#16
Volkan Doğan, Özcan Başaran, Murat Biteker, Fatma Özpamuk Karadeniz, Ahmet İlker Tekkesin, Yasin Çakıllı, Ceyhan Türkkan, Mehmet Hamidi, Vahit Demir, Mustafa Ozan Gürsoy, Müjgan Tek Öztürk, Gökhan Aksan, Sabri Seyis, Mehmet Ballı, Mehmet Hayri Alıcı, Serdar Bozyel, Cevat Kırma
OBJECTIVE: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical regions of Turkey. METHODS: In total, 6273 patients were enrolled to this prospective, observational RAMSES study. The patients were divided into seven groups based on the geographical region of residence. RESULTS: In terms of the geographical distribution of the overall Turkish population, the highest number of patients were enrolled from Marmara (1677, 26...
August 11, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28795332/the-patterns-of-non-vitamin-k-antagonist-oral-anticoagulants-noacs-use-in-patients-with-atrial-fibrillation-in-seven-balkan-countries-a-report-from-the-balkan-af-survey
#17
Tatjana S Potpara, Elina Trendafilova, Gheorghe-Andrei Dan, Artan Goda, Zumreta Kusljugic, Sime Manola, Ljilja Music, Viktor Gjini, Belma Pojskic, Mircea Ioakim Popescu, Catalina Arsenescu Georgescu, Elena S Dimitrova, Delyana Kamenova, Uliks Ekmeciu, Denis Mrsic, Ana Nenezic, Sandro Brusich, Srdjan Milanov, Ivan Zeljkovic, Gregory Y H Lip
INTRODUCTION: Data on management of atrial fibrillation (AF) in the Balkan Region are scarce. To capture the patterns in AF management in contemporary clinical practice in the Balkan countries a prospective survey was conducted between December 2014 and February 2015, and we report results pertinent to the use of non-vitamin K antagonist oral anticoagulants (NOACs). METHODS: A 14-week prospective, multicenter survey of consecutive AF patients seen by cardiologists or internal medicine specialists was conducted in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Montenegro, Romania, and Serbia (a total of about 50 million inhabitants)...
August 9, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28792509/regional-citrate-anticoagulation-for-continuous-renal-replacement-therapy-in-pediatric-patients-with-liver-failure
#18
Keila Rodriguez, Poyyapakkam R Srivaths, Leyat Tal, Mary N Watson, Alyssa A Riley, Ryan W Himes, Moreshwar S Desai, Michael C Braun, Ayse Akcan Arikan
Pediatric liver failure patients frequently develop multiple organ failure and require continuous renal replacement therapy (CRRT) as part of supportive therapy in the pediatric intensive care unit. While many centers employ no anticoagulation for fear of bleeding complications, balanced coagulation disturbance predisposes these patients to clotting as well as bleeding, making maintenance of longer circuit life to deliver adequate dialysis clearance challenging. Regional citrate anticoagulation (RCA) is an attractive option as it avoids systemic anticoagulation, but since citrate metabolism is impaired in liver failure, concerns about toxicity has limited its use...
2017: PloS One
https://www.readbyqxmd.com/read/28780302/systematic-assessment-reveals-lack-of-understandability-for-prostate-biopsy-online-patient-education-materials
#19
Kimberly A Maciolek, David F Jarrard, E Jason Abel, Sara L Best
OBJECTIVE: To evaluate the accuracy, readability, understandability and actionability of internet patient education materials (PEM) about transrectal ultrasound-guided (TRUS) prostate biopsy. MATERIALS AND METHODS: A comprehensive internet search was performed to find PEM with pre- or post-biopsy instructions. PEM that were duplicates, government affiliated, international, or video-based were excluded. Biopsy instructions were evaluated for accuracy and presence of essential topics...
August 2, 2017: Urology
https://www.readbyqxmd.com/read/28770943/insights-into-the-role-of-3-o-sulfotransferase-in-heparan-sulfate-biosynthesis
#20
Maria Cecília Zorél Meneghetti, Tarsis Gesteira Ferreira, Alexandre Keiji Tashima, Suely F Chavante, Edwin Alexander Yates, Jian Liu, Helena Bonciani Nader, Marcelo A Lima
3-O-Sulfotransferase enzyme (sHS) from Litopenaeus vannamei was cloned and its substrate specificity was investigated against a number of GAG structures, including modified heparin polysaccharides and model oligosaccharides. For the heparin polysaccharides, derived from porcine intestinal mucosa heparin, sulfate groups were incorporated into glucosamine residues containing both N-sulfated and N-acetylated substitution within the regions of the predominant repeating disaccharide, either I-ANS or I-ANAc. However, the resulting polysaccharides did not stabilize antithrombin, which is correlated with anticoagulant activity...
August 16, 2017: Organic & Biomolecular Chemistry
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