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https://www.readbyqxmd.com/read/28217415/muscle-activation-patterns-during-suspension-training-exercises
#1
Sean Harris, Elise Ruffin, Wayne Brewer, Alexis Ortiz
BACKGROUND: Suspension training (ST) has been utilized over exercises performed on a stable surface to train multiple muscle groups simultaneously to increase muscle activation and joint stability. HYPOTHESIS/PURPOSE: The purpose of this study was to determine whether ST augments muscle activation compared to similar exercises performed on a stable surface. STUDY DESIGN: Cross-sectional study. METHODS: Twenty-five healthy adults (male: 16; women: 9; BMI: 23...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28070282/the-database-of-the-predicts-projecting-responses-of-ecological-diversity-in-changing-terrestrial-systems-project
#2
Lawrence N Hudson, Tim Newbold, Sara Contu, Samantha L L Hill, Igor Lysenko, Adriana De Palma, Helen R P Phillips, Tamera I Alhusseini, Felicity E Bedford, Dominic J Bennett, Hollie Booth, Victoria J Burton, Charlotte W T Chng, Argyrios Choimes, David L P Correia, Julie Day, Susy Echeverría-Londoño, Susan R Emerson, Di Gao, Morgan Garon, Michelle L K Harrison, Daniel J Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D Martin, Yuan Pan, Gwilym D Pask-Hale, Edwin L Pynegar, Alexandra N Robinson, Katia Sanchez-Ortiz, Rebecca A Senior, Benno I Simmons, Hannah J White, Hanbin Zhang, Job Aben, Stefan Abrahamczyk, Gilbert B Adum, Virginia Aguilar-Barquero, Marcelo A Aizen, Belén Albertos, E L Alcala, Maria Del Mar Alguacil, Audrey Alignier, Marc Ancrenaz, Alan N Andersen, Enrique Arbeláez-Cortés, Inge Armbrecht, Víctor Arroyo-Rodríguez, Tom Aumann, Jan C Axmacher, Badrul Azhar, Adrián B Azpiroz, Lander Baeten, Adama Bakayoko, András Báldi, John E Banks, Sharad K Baral, Jos Barlow, Barbara I P Barratt, Lurdes Barrico, Paola Bartolommei, Diane M Barton, Yves Basset, Péter Batáry, Adam J Bates, Bruno Baur, Erin M Bayne, Pedro Beja, Suzan Benedick, Åke Berg, Henry Bernard, Nicholas J Berry, Dinesh Bhatt, Jake E Bicknell, Jochen H Bihn, Robin J Blake, Kadiri S Bobo, Roberto Bóçon, Teun Boekhout, Katrin Böhning-Gaese, Kevin J Bonham, Paulo A V Borges, Sérgio H Borges, Céline Boutin, Jérémy Bouyer, Cibele Bragagnolo, Jodi S Brandt, Francis Q Brearley, Isabel Brito, Vicenç Bros, Jörg Brunet, Grzegorz Buczkowski, Christopher M Buddle, Rob Bugter, Erika Buscardo, Jörn Buse, Jimmy Cabra-García, Nilton C Cáceres, Nicolette L Cagle, María Calviño-Cancela, Sydney A Cameron, Eliana M Cancello, Rut Caparrós, Pedro Cardoso, Dan Carpenter, Tiago F Carrijo, Anelena L Carvalho, Camila R Cassano, Helena Castro, Alejandro A Castro-Luna, Cerda B Rolando, Alexis Cerezo, Kim Alan Chapman, Matthieu Chauvat, Morten Christensen, Francis M Clarke, Daniel F R Cleary, Giorgio Colombo, Stuart P Connop, Michael D Craig, Leopoldo Cruz-López, Saul A Cunningham, Biagio D'Aniello, Neil D'Cruze, Pedro Giovâni da Silva, Martin Dallimer, Emmanuel Danquah, Ben Darvill, Jens Dauber, Adrian L V Davis, Jeff Dawson, Claudio de Sassi, Benoit de Thoisy, Olivier Deheuvels, Alain Dejean, Jean-Louis Devineau, Tim Diekötter, Jignasu V Dolia, Erwin Domínguez, Yamileth Dominguez-Haydar, Silvia Dorn, Isabel Draper, Niels Dreber, Bertrand Dumont, Simon G Dures, Mats Dynesius, Lars Edenius, Paul Eggleton, Felix Eigenbrod, Zoltán Elek, Martin H Entling, Karen J Esler, Ricardo F de Lima, Aisyah Faruk, Nina Farwig, Tom M Fayle, Antonio Felicioli, Annika M Felton, Roderick J Fensham, Ignacio C Fernandez, Catarina C Ferreira, Gentile F Ficetola, Cristina Fiera, Bruno K C Filgueiras, Hüseyin K Fırıncıoğlu, David Flaspohler, Andreas Floren, Steven J Fonte, Anne Fournier, Robert E Fowler, Markus Franzén, Lauchlan H Fraser, Gabriella M Fredriksson, Geraldo B Freire, Tiago L M Frizzo, Daisuke Fukuda, Dario Furlani, René Gaigher, Jörg U Ganzhorn, Karla P García, Juan C Garcia-R, Jenni G Garden, Ricardo Garilleti, Bao-Ming Ge, Benoit Gendreau-Berthiaume, Philippa J Gerard, Carla Gheler-Costa, Benjamin Gilbert, Paolo Giordani, Simonetta Giordano, Carly Golodets, Laurens G L Gomes, Rachelle K Gould, Dave Goulson, Aaron D Gove, Laurent Granjon, Ingo Grass, Claudia L Gray, James Grogan, Weibin Gu, Moisès Guardiola, Nihara R Gunawardene, Alvaro G Gutierrez, Doris L Gutiérrez-Lamus, Daniela H Haarmeyer, Mick E Hanley, Thor Hanson, Nor R Hashim, Shombe N Hassan, Richard G Hatfield, Joseph E Hawes, Matt W Hayward, Christian Hébert, Alvin J Helden, John-André Henden, Philipp Henschel, Lionel Hernández, James P Herrera, Farina Herrmann, Felix Herzog, Diego Higuera-Diaz, Branko Hilje, Hubert Höfer, Anke Hoffmann, Finbarr G Horgan, Elisabeth Hornung, Roland Horváth, Kristoffer Hylander, Paola Isaacs-Cubides, Hiroaki Ishida, Masahiro Ishitani, Carmen T Jacobs, Víctor J Jaramillo, Birgit Jauker, F Jiménez Hernández, McKenzie F Johnson, Virat Jolli, Mats Jonsell, S Nur Juliani, Thomas S Jung, Vena Kapoor, Heike Kappes, Vassiliki Kati, Eric Katovai, Klaus Kellner, Michael Kessler, Kathryn R Kirby, Andrew M Kittle, Mairi E Knight, Eva Knop, Florian Kohler, Matti Koivula, Annette Kolb, Mouhamadou Kone, Ádám Kőrösi, Jochen Krauss, Ajith Kumar, Raman Kumar, David J Kurz, Alex S Kutt, Thibault Lachat, Victoria Lantschner, Francisco Lara, Jesse R Lasky, Steven C Latta, William F Laurance, Patrick Lavelle, Violette Le Féon, Gretchen LeBuhn, Jean-Philippe Légaré, Valérie Lehouck, María V Lencinas, Pia E Lentini, Susan G Letcher, Qi Li, Simon A Litchwark, Nick A Littlewood, Yunhui Liu, Nancy Lo-Man-Hung, Carlos A López-Quintero, Mounir Louhaichi, Gabor L Lövei, Manuel Esteban Lucas-Borja, Victor H Luja, Matthew S Luskin, M Cristina MacSwiney G, Kaoru Maeto, Tibor Magura, Neil Aldrin Mallari, Louise A Malone, Patrick K Malonza, Jagoba Malumbres-Olarte, Salvador Mandujano, Inger E Måren, Erika Marin-Spiotta, Charles J Marsh, E J P Marshall, Eliana Martínez, Guillermo Martínez Pastur, David Moreno Mateos, Margaret M Mayfield, Vicente Mazimpaka, Jennifer L McCarthy, Kyle P McCarthy, Quinn S McFrederick, Sean McNamara, Nagore G Medina, Rafael Medina, Jose L Mena, Estefania Mico, Grzegorz Mikusinski, Jeffrey C Milder, James R Miller, Daniel R Miranda-Esquivel, Melinda L Moir, Carolina L Morales, Mary N Muchane, Muchai Muchane, Sonja Mudri-Stojnic, A Nur Munira, Antonio Muoñz-Alonso, B F Munyekenye, Robin Naidoo, A Naithani, Michiko Nakagawa, Akihiro Nakamura, Yoshihiro Nakashima, Shoji Naoe, Guiomar Nates-Parra, Dario A Navarrete Gutierrez, Luis Navarro-Iriarte, Paul K Ndang'ang'a, Eike L Neuschulz, Jacqueline T Ngai, Violaine Nicolas, Sven G Nilsson, Norbertas Noreika, Olivia Norfolk, Jorge Ari Noriega, David A Norton, Nicole M Nöske, A Justin Nowakowski, Catherine Numa, Niall O'Dea, Patrick J O'Farrell, William Oduro, Sabine Oertli, Caleb Ofori-Boateng, Christopher Omamoke Oke, Vicencio Oostra, Lynne M Osgathorpe, Samuel Eduardo Otavo, Navendu V Page, Juan Paritsis, Alejandro Parra-H, Luke Parry, Guy Pe'er, Peter B Pearman, Nicolás Pelegrin, Raphaël Pélissier, Carlos A Peres, Pablo L Peri, Anna S Persson, Theodora Petanidou, Marcell K Peters, Rohan S Pethiyagoda, Ben Phalan, T Keith Philips, Finn C Pillsbury, Jimmy Pincheira-Ulbrich, Eduardo Pineda, Joan Pino, Jaime Pizarro-Araya, A J Plumptre, Santiago L Poggio, Natalia Politi, Pere Pons, Katja Poveda, Eileen F Power, Steven J Presley, Vânia Proença, Marino Quaranta, Carolina Quintero, Romina Rader, B R Ramesh, Martha P Ramirez-Pinilla, Jai Ranganathan, Claus Rasmussen, Nicola A Redpath-Downing, J Leighton Reid, Yana T Reis, José M Rey Benayas, Juan Carlos Rey-Velasco, Chevonne Reynolds, Danilo Bandini Ribeiro, Miriam H Richards, Barbara A Richardson, Michael J Richardson, Rodrigo Macip Ríos, Richard Robinson, Carolina A Robles, Jörg Römbke, Luz Piedad Romero-Duque, Matthias Rös, Loreta Rosselli, Stephen J Rossiter, Dana S Roth, T'ai H Roulston, Laurent Rousseau, André V Rubio, Jean-Claude Ruel, Jonathan P Sadler, Szabolcs Sáfián, Romeo A Saldaña-Vázquez, Katerina Sam, Ulrika Samnegård, Joana Santana, Xavier Santos, Jade Savage, Nancy A Schellhorn, Menno Schilthuizen, Ute Schmiedel, Christine B Schmitt, Nicole L Schon, Christof Schüepp, Katharina Schumann, Oliver Schweiger, Dawn M Scott, Kenneth A Scott, Jodi L Sedlock, Steven S Seefeldt, Ghazala Shahabuddin, Graeme Shannon, Douglas Sheil, Frederick H Sheldon, Eyal Shochat, Stefan J Siebert, Fernando A B Silva, Javier A Simonetti, Eleanor M Slade, Jo Smith, Allan H Smith-Pardo, Navjot S Sodhi, Eduardo J Somarriba, Ramón A Sosa, Grimaldo Soto Quiroga, Martin-Hugues St-Laurent, Brian M Starzomski, Constanti Stefanescu, Ingolf Steffan-Dewenter, Philip C Stouffer, Jane C Stout, Ayron M Strauch, Matthew J Struebig, Zhimin Su, Marcela Suarez-Rubio, Shinji Sugiura, Keith S Summerville, Yik-Hei Sung, Hari Sutrisno, Jens-Christian Svenning, Tiit Teder, Caragh G Threlfall, Anu Tiitsaar, Jacqui H Todd, Rebecca K Tonietto, Ignasi Torre, Béla Tóthmérész, Teja Tscharntke, Edgar C Turner, Jason M Tylianakis, Marcio Uehara-Prado, Nicolas Urbina-Cardona, Denis Vallan, Adam J Vanbergen, Heraldo L Vasconcelos, Kiril Vassilev, Hans A F Verboven, Maria João Verdasca, José R Verdú, Carlos H Vergara, Pablo M Vergara, Jort Verhulst, Massimiliano Virgilio, Lien Van Vu, Edward M Waite, Tony R Walker, Hua-Feng Wang, Yanping Wang, James I Watling, Britta Weller, Konstans Wells, Catrin Westphal, Edward D Wiafe, Christopher D Williams, Michael R Willig, John C Z Woinarski, Jan H D Wolf, Volkmar Wolters, Ben A Woodcock, Jihua Wu, Joseph M Wunderle, Yuichi Yamaura, Satoko Yoshikura, Douglas W Yu, Andrey S Zaitsev, Juliane Zeidler, Fasheng Zou, Ben Collen, Rob M Ewers, Georgina M Mace, Drew W Purves, Jörn P W Scharlemann, Andy Purvis
The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/27935476/assessing-the-mechanism-and-therapeutic-potential-of-modulators-of-the-human-mediator-complex-associated-protein-kinases
#3
Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Ken Ewan, Sharon Gowan, Alexis De Haven Brandon, Phillip Hewitt, Stephen M Hobbs, Wolfgang Kaufmann, Aurélie Mallinger, Florence Raynaud, Toby Roe, Felix Rohdich, Kai Schiemann, Stephanie Simon, Richard Schneider, Melanie Valenti, Stefan Weigt, Julian Blagg, Andree Blaukat, Trevor C Dale, Suzanne A Eccles, Stefan Hecht, Klaus Urbahns, Paul Workman, Dirk Wienke
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We discovered two series of potent chemical probes with high selectivity for CDK8/19. Despite pharmacodynamic evidence for robust on-target activity, the compounds exhibited modest, though significant, efficacy against human tumor lines and patient-derived xenografts...
December 9, 2016: ELife
https://www.readbyqxmd.com/read/27881142/ethnoagroforestry-integration-of-biocultural-diversity-for-food-sovereignty-in-mexico
#4
Ana Isabel Moreno-Calles, Alejandro Casas, Alexis Daniela Rivero-Romero, Yessica Angélica Romero-Bautista, Selene Rangel-Landa, Roberto Alexander Fisher-Ortíz, Fernando Alvarado-Ramos, Mariana Vallejo-Ramos, Dídac Santos-Fita
BACKGROUND: Documenting the spectrum of ecosystem management, the roles of forestry and agricultural biodiversity, TEK, and human culture for food sovereignty, are all priority challenges for contemporary science and society. Ethnoagroforestry is a research approach that provides a theoretical framework integrating socio-ecological disciplines and TEK. We analyze in this study general types of Agroforestry Systems of México, in which peasants, small agriculturalist, and indigenous people are the main drivers of AFS and planning of landscape diversity use...
November 23, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27650101/music-expected-maximization-gaussian-mixture-methodology-for-clustering-and-detection-of-task-related-neuronal-firing-rates
#5
Alexis Ortiz-Rosario, Hojjat Adeli, John A Buford
Researchers often rely on simple methods to identify involvement of neurons in a particular motor task. The historical approach has been to inspect large groups of neurons and subjectively separate neurons into groups based on the expertise of the investigator. In cases where neuron populations are small it is reasonable to inspect these neuronal recordings and their firing rates carefully to avoid data omissions. In this paper, a new methodology is presented for automatic objective classification of neurons recorded in association with behavioral tasks into groups...
January 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27361339/a-comparison-of-work-related-physical-activity-levels-between-inpatient-and-outpatient-physical-therapists-2703-board-226-june-3-11-00-am-12-30-pm
#6
Wayne Brewer, Raluchukwu Ogbazi, Alexis Ortiz
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360705/effectiveness-of-a-home-based-exercise-intervention-in-fitness-profile-in-hispanic-breast-cancer-survivors-1880-board-32-june-2-3-30-pm-5-00-pm
#7
Alexis Ortiz, Daniel C Hughes, Maribel Tirado-Gomez, Velda J Gonzalez-Mercado, JaeJoon Song, Karen Basen-Engquist
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27313480/reliability-and-concurrent-validity-between-two-dimensional-and-three-dimensional-evaluations-of-knee-valgus-during-drop-jumps
#8
Alexis Ortiz, Martin Rosario-Canales, Alejandro Rodríguez, Alexie Seda, Carla Figueroa, Heidi L Venegas-Ríos
PURPOSE: The aim of this study was to establish the concurrent validity and reliability of four different two-dimensional (2D) video-based techniques for quantifying frontal plane knee kinematics during a 40 cm double-legged drop jump. PARTICIPANTS AND METHODS: A convenience sample of 16 healthy participants (nine males and seven females; age: [mean ± standard deviation] 25.5±2 years; body mass index: 24.33±2.98 kg/m(2)) participated in this investigation. A total of five trials during a 40 cm drop jump maneuver with a countermovement jump were used as the functional task...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27306457/a-comparison-of-work-related-physical-activity-levels-between-inpatient-and-outpatient-physical-therapists-an-observational-cohort-trial
#9
COMPARATIVE STUDY
Wayne Brewer, Raluchukwu Ogbazi, Devan Ohl, Jeffry Daniels, Alexis Ortiz
BACKGROUND: Physical therapists (PTs) work in a variety of healthcare settings with varied levels of physical activity demands placed on them. The purpose of this study is to compare the physical activity (PA) levels between PTs in inpatient versus outpatient environments for one work week using a cross-sectional design. METHODS: Sixty-one PTs (30 inpatient, 31 outpatient) wore a tri-axial accelerometer and inclinometer for one work-week. The number steps-per-day, PA intensities, energy expenditures and postural positions adopted during the work day were recorded...
June 16, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27270719/erratum-to-superselective-intraarterial-cerebral-infusion-of-cetuximab-after-osmotic-blood-brain-barrier-disruption-for-recurrent-malignant-glioma-phase-i-study
#10
Shamik Chakraborty, Christopher G Filippi, Tamika Wong, Ashley Ray, Sherese Fralin, A John Tsiouris, Bidyut Praminick, Alexis Demopoulos, Heather J McCrea, Imithri Bodhinayake, Rafael Ortiz, David J Langer, John A Boockvar
No abstract text is available yet for this article.
July 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27252577/emg-activity-of-selected-rotator-cuff-musculature-during-grade-iii-distraction-and-posterior-glide-glenohumeral-mobilization-results-of-a-pilot-trial-comparing-painful-and-non-painful-shoulders
#11
Brian T Swanson, Brian Holst, John Infante, James Poenitzsch, Alexis Ortiz
OBJECTIVES: The objectives of this pilot study were to investigate rotator cuff activity that may be present during grade III distraction and posterior glide mobilization of the glenohumeral (GH) joint, as well as to examine any differences in response between painful and non-painful shoulders utilizing these techniques. METHODS: EMG data were collected using Delsys EMGworks(®) software and Trigno(®) mini-wireless electrodes for the supraspinatus, infraspinatus and upper trapezius musculature during grade III GH distraction and posterior glide mobilization...
February 2016: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/26984227/dietary-patterns-in-puerto-rican-and-mexican-american-breast-cancer-survivors-a-pilot-study
#12
Cristina Palacios, Carrie R Daniel, Maribel Tirado-Gómez, Velda Gonzalez-Mercado, Liliana Vallejo, Jose Lozada, Alexis Ortiz, Daniel C Hughes, Karen Basen-Engquist
Breast cancer is the leading cause of cancer death among Hispanic women. Certain dietary factors have been associated with the risk of breast cancer recurrence, but data in Hispanic survivors is scarce. OBJECTIVE: to examine dietary patterns and diet quality in two groups of Hispanic breast cancer survivors. METHODS: 23 Mexican-American (MA) and 22 Puerto Rican (PR) female breast cancer survivors completed a culturally adapted validated food frequency questionnaire...
April 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/26945581/superselective-intraarterial-cerebral-infusion-of-cetuximab-after-osmotic-blood-brain-barrier-disruption-for-recurrent-malignant-glioma-phase-i-study
#13
Shamik Chakraborty, Christopher G Filippi, Tamika Wong, Ashley Ray, Sherese Fralin, A John Tsiouris, Bidyut Praminick, Alexis Demopoulos, Heather J McCrea, Imithri Bodhinayake, Rafael Ortiz, David J Langer, John A Boockvar
Objective To establish a maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of Cetuximab after osmotic disruption of the blood-brain barrier (BBB) with mannitol, and examine safety of the procedure in patients with recurrent malignant glioma. Methods A total of 15 patients with recurrent malignant glioma were included in the current study. The starting dose of Cetuximab was 100 mg/m(2) and dose escalation was done to 250 mg/m(2). All patients were observed for 28 days post-infusion for any side effects...
July 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26829467/optimization-of-a-recombinant-human-growth-hormone-purification-process-using-quality-by-design
#14
Carolina Ortiz-Enriquez, Alexis de Jesús Romero-Díaz, Ana V Hernández-Moreno, Hugo F Cueto-Rojas, Mariana P Miranda-Hernández, Carlos A López-Morales, Néstor O Pérez, Rodolfo Salazar-Ceballos, Norberto Cruz-García, Luis F Flores-Ortiz, Emilio Medina-Rivero
This work describes a strategy to optimize a downstream processing of a recombinant human growth hormone (rhGH) by incorporating a quality by design approach toward meeting higher quality specifications. The optimized process minimized the presence of impurities and degradation by-products during manufacturing by the establishment of in-process controls. Capillary zone electrophoresis, reverse phase, and size-exclusion chromatographies were used as analytical techniques to establish new critical process parameters for the solubilization, capture, and intermediate purification steps aiming to maintain rhGH quality by complying with pharmacopeial specifications...
November 16, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/26796641/discovery-of-potent-selective-and-orally-bioavailable-small-molecule-modulators-of-the-mediator-complex-associated-kinases-cdk8-and-cdk19
#15
Aurélie Mallinger, Kai Schiemann, Christian Rink, Frank Stieber, Michel Calderini, Simon Crumpler, Mark Stubbs, Olajumoke Adeniji-Popoola, Oliver Poeschke, Michael Busch, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Maria-Jesus Ortiz-Ruiz, Richard Schneider, Ching Thai, Melanie Valenti, Alexis de Haven Brandon, Rosemary Burke, Paul Workman, Trevor Dale, Dirk Wienke, Paul A Clarke, Christina Esdar, Florence I Raynaud, Suzanne A Eccles, Felix Rohdich, Julian Blagg
The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene. Here we report the discovery of 109 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity for CDK19. We describe a structure-based design approach leading to the discovery of a 3,4,5-trisubstituted-2-aminopyridine series and present the application of physicochemical property analyses to successfully reduce in vivo metabolic clearance, minimize transporter-mediated biliary elimination while maintaining acceptable aqueous solubility...
February 11, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26602701/longitudinal-social-cognitive-influences-on-physical-activity-and-sedentary-time-in-hispanic-breast-cancer-survivors
#16
Scherezade K Mama, Jaejoon Song, Alexis Ortiz, Maribel Tirado-Gomez, Cristina Palacios, Daniel C Hughes, Karen Basen-Engquist
OBJECTIVE: This study evaluated the effect of two home-based exercise interventions (one culturally adapted and one standard) on changes in social cognitive theory (SCT) variables, physical activity (PA), and sedentary time (ST), and determined the association between changes in SCT variables and changes in PA and ST in Hispanic breast cancer survivors. METHOD: Project VIVA! was a 16-week randomized controlled pilot study to test the effectiveness and feasibility of a culturally adapted exercise intervention for Mexican American and Puerto Rican breast cancer survivors in Houston, Texas and San Juan, Puerto Rico, respectively...
February 2017: Psycho-oncology
https://www.readbyqxmd.com/read/26346332/comparison-of-eccentric-and-concentric-exercise-interventions-in-adults-with-subacromial-impingement-syndrome
#17
Christiana Blume, Sharon Wang-Price, Elaine Trudelle-Jackson, Alexis Ortiz
BACKGROUND: Researchers have demonstrated moderate evidence for the use of exercise in the treatment of subacromial impingement syndrome (SAIS). Recent evidence also supports eccentric exercise for patients with lower extremity and wrist tendinopathies. However, only a few investigators have examined the effects of eccentric exercise on patients with rotator cuff tendinopathy. PURPOSE: To compare the effectiveness of an eccentric progressive resistance exercise (PRE) intervention to a concentric PRE intervention in adults with SAIS...
August 2015: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/26182003/157%C3%A2-neurocognitive-decline-and-recovery-in-patients-undergoing-microsurgical-vs-endovascular-treatment-of-unruptured-intracranial-aneurysms
#18
Angi Caveney, Aditya S Pandey, Scott A Langenecker, Laura Gabriel, J Alexis Ortiz, Nadia Huq, Runa Bhaumik, Byron Gregory Thompson, Bruno J Giordani, Donna L Auer, Lewis Morgenstern
INTRODUCTION: Neurocognitive changes postsurgical clipping (SC) or endovascular coiling (EC) of unruptured aneurysms is not well studied. We aim to understand whether patients who undergo EC perform better on neurocognitive assessments in comparison with patients who undergo SC, and if such a difference exists how long the difference persists. METHODS: This is a single-center, prospective, longitudinal study with patients divided into the microsurgical, endovascular, and healthy control (HC) groups...
August 2015: Neurosurgery
https://www.readbyqxmd.com/read/26075238/physicochemical-and-biological-characterization-of-a-biosimilar-trastuzumab
#19
Carlos A López-Morales, Mariana P Miranda-Hernández, L Carmina Juárez-Bayardo, Nancy D Ramírez-Ibáñez, Alexis J Romero-Díaz, Nelly Piña-Lara, Víctor R Campos-García, Néstor O Pérez, Luis F Flores-Ortiz, Emilio Medina-Rivero
According to the World Health Organization, the incidence of malignant neoplasms and endocrine, blood, and immune disorders will increase in the upcoming decades along with the demand of affordable treatments. In response to this need, the development of biosimilar drugs is increasing worldwide. The approval of biosimilars relies on the compliance with international guidelines, starting with the demonstration of similarity in their physicochemical and functional properties against the reference product. Subsequent clinical studies are performed to demonstrate similar pharmacological behavior and to diminish the uncertainty related to their safety and efficacy...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25868651/individual-versus-pooled-multiple-lumen-blood-cultures-for-the-diagnosis-of-intravascular-catheter-related-infections
#20
COMPARATIVE STUDY
Alexis Samara Herrera-Guerra, Elvira Garza-González, Michel Fernando Martínez-Resendez, Jorge Martín Llaca-Díaz, Adrián Camacho-Ortiz
BACKGROUND: The current gold standard method for diagnosis of central-line associated bloodstream infections (CLABSIs) requires central venous catheter removal and a positive culture of the CVC tip with a positive peripheral blood culture. STUDY DESIGN: Comparative study. METHODS: We compared individual blood cultures from each catheter lumen versus a pooled-blood culture bottle containing blood samples from every catheter lumen for the diagnosis of CLABSI...
July 1, 2015: American Journal of Infection Control
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