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https://www.readbyqxmd.com/read/28063172/prognostic-value-of-the-microrna-29-family-in-multiple-human-cancers-a-meta-analysis-and-systematic-review
#1
Yan Qi, Yalan Huang, Lijuan Pang, Wenyi Gu, Ning Wang, Jianming Hu, Xiaobin Cui, Jun Zhang, Jin Zhao, Chunxia Liu, Wenjie Zhang, Hong Zou, Feng Li
MicroRNAs (miRNAs) in cancer development have attracted much attention in recent years. miR-29 is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain situations. The prognostic value of miR-29 family in cancer progression is still under debate and reported results are inconsistent. Therefore, we reported here a meta-analysis and systematic review to analyze the prognostic role of miR-29 family in cancer. We screened 20 published studies and calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for overall survival (OS) or disease-free survival/recurrence-free survival (DFS/RFS)...
January 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28038351/microrna-29-impairs-the-early-phase-of-reprogramming-process-by-targeting-active-dna-demethylation-enzymes-and-wnt-signaling
#2
Mariane Serra Fráguas, Reto Eggenschwiler, Jeannine Hoepfner, Josiane Lilian Dos Santos Schiavinato, Rodrigo Haddad, Lucila Habib Bourguignon Oliveira, Amélia Góes Araújo, Marco Antônio Zago, Rodrigo Alexandre Panepucci, Tobias Cantz
Somatic cell reprogramming by transcription factors and other modifiers such as microRNAs has opened broad avenues for the study of developmental processes, cell fate determination, and interplay of molecular mechanisms in signaling pathways. However, many of the mechanisms that drive nuclear reprogramming itself remain yet to be elucidated. Here, we analyzed the role of miR-29 during reprogramming in more detail. Therefore, we evaluated miR-29 expression during reprogramming of fibroblasts transduced with lentiviral OKS and OKSM vectors and we show that addition of c-MYC to the reprogramming factor cocktail decreases miR-29 expression levels...
December 19, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27986463/tamoxifen-differentially-regulates-mir-29b-1-and-mir-29a-expression-depending-on-endocrine-sensitivity-in-breast-cancer-cells
#3
Penn Muluhngwi, Abirami Krishna, Stephany L Vittitow, Joshua T Napier, Kirsten M Richardson, Mackenzie Ellis, Justin L Mott, Carolyn M Klinge
Endocrine-resistance develops in ∼40% of breast cancer patients after tamoxifen (TAM) therapy. Although microRNAs are dysregulated in breast cancer, their contribution to endocrine-resistance is not yet understood. Previous microarray analysis identified miR-29a and miR-29b-1 as repressed by TAM in MCF-7 endocrine-sensitive breast cancer cells but stimulated by TAM in LY2 endocrine-resistant breast cancer cells. Here we examined the mechanism for the differential regulation of these miRs by TAM in MCF-7 versus TAM-resistant LY2 and LCC9 breast cancer cells and the functional role of these microRNAs in these cells...
December 13, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27981880/transcriptome-profiling-of-the-developing-male-germ-line-identifies-the-mir-29-family-as-a-global-regulator-during-meiosis
#4
Stephanie Hilz, Elizabeth A Fogarty, Andrew J Modzelewski, Paula E Cohen, Andrew Grimson
MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly understood. Here, we generate and analyze paired small RNA and mRNA profiles across different stages of germline development in male mice, focusing on time points shortly before and during meiotic prophase I...
December 16, 2016: RNA Biology
https://www.readbyqxmd.com/read/27981346/altered-expression-of-apoptosis-regulating-mirnas-in-salivary-gland-tumors-suggests-their-involvement-in-salivary-gland-tumorigenesis
#5
Bianca de Cássia Troncarelli de Campos Parra Flores, Silvia Vanessa Lourenço, Aline Santos Damascena, Luiz Paulo Kowaslki, Fernando Augusto Soares, Cláudia Malheiros Coutinho-Camillo
Salivary gland tumors comprise a heterogeneous group of lesions with different histological features and diverse clinical pathophysiology. They account for about 3% of all head and neck tumors. Apoptosis plays an important role during morphogenesis of glandular structures, including that of the salivary gland. Recent studies have demonstrated that several microRNAs (miRNAs) are involved in the control of apoptosis. The aim of the present study was to determine the expression of apoptosis-related miRNAs (miR-15a, miR-16, miR-17-5p, miR-20a, miR-21, miR-29, and miR-34) and their target mRNAs in 25 pleomorphic adenomas, 23 mucoepidermoid carcinomas, and 10 non-neoplastic salivary gland samples by real-time RT-PCR...
December 15, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27932253/regulation-of-cyclin-d1-by-arsenic-and-microrna-inhibits-adipogenesis
#6
Kevin Beezhold, Linda R Klei, Aaron Barchowsky
Low-dose chronic exposure to arsenic in drinking water represents a global public health concern with established risks for metabolic and cardiovascular disease, as well as cancer. While the linkage between arsenic and disease is strong, further understanding of the molecular mechanisms of its pathogenicity is required. Previous reports demonstrated the ability of arsenic to interfere with adipogenesis, which may mediate its effects in promoting metabolic disease. We hypothesized that microRNA are important regulators of most if not all mesenchymal stem cell processes that are dysregulated by arsenic exposure to impair lipogenesis...
January 4, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27924640/the-association-of-circulating-mir-30a-mir-29-and-mir-133-with-white-coat-hypertension
#7
Yu-Qing Huang, Cheng Huang, Ji-Yan Chen, Jie Li, Ying-Qing Feng
AIM: The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD: Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The area under the receiver-operating characteristic curve was used to evaluate diagnostic accuracy. RESULTS: MiR-30a yielded an AUC of 0...
December 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27922664/expression-of-bcl-2-and-micrornas-in-cardiac-tissues-of-patients-with-dilated-cardiomyopathy
#8
Yong Wang, Min Li, Li Xu, Ju Liu, Dong Wang, Quan Li, Lili Wang, Peijie Li, Shanliang Chen, Tianqi Liu
Dilated cardiomyopathy (DCM) is associated with sudden cardiac death and heart failure, resulting in a significant medical burden. The mechanisms underlying the pathogenesis of DCM remain elusive. In the present study, human cardiac tissues from patients with DCM and healthy donors were collected and their pathology was examined. The expression levels of apoptosis regulator Bcl-2 and fibrosis-associated microRNAs were also evaluated. Extensive myocardial fibrosis and apoptosis in DCM cardiac tissues was observed...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27916417/ccl20-ccr6-promotes-cell-proliferation-and-metastasis-in-laryngeal-cancer-by-activating-p38-pathway
#9
Eryong Lu, Jili Su, Yanhui Zhou, Chao Zhang, Yuehui Wang
Chemokine and its receptors play important roles in laryngeal cancer development and progression. CCR6 is the receptor of CCL20 chemokine, but its function in laryngeal cancer is not known. The aim of this study is to explore the roles of CCR6 and its regulation mechanism in laryngeal cancer. We found CCR6 expression was higher in laryngeal cancer tissues compared with their normal controls, so did in laryngeal cancer cells. Cellular function indicated that down-regulation of CCR6 in laryngeal cancer cells could suppress cell proliferation and metastasis...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27889210/relations-between-circulating-micrornas-mir-21-mir-26-mir-29-mir-30-and-mir-133a-extracellular-matrix-fibrosis-and-serum-markers-of-fibrosis-in-dilated-cardiomyopathy
#10
Paweł Rubiś, Justyna Totoń-Żurańska, Sylwia Wiśniowska-Śmiałek, Katarzyna Holcman, Maria Kołton-Wróż, Paweł Wołkow, Ewa Wypasek, Joanna Natorska, Lucyna Rudnicka-Sosin, Agnieszka Pawlak, Artur Kozanecki, Piotr Podolec
No abstract text is available yet for this article.
November 18, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27836951/expression-of-micrornas-that-regulate-bone-turnover-in-the-serum-of-postmenopausal-women-with-low-bone-mass-and-vertebral-fractures
#11
Maria P Yavropoulou, Athanasios D Anastasilakis, Polyzois Makras, Dimitrios G Tsalikakis, Maria Grammatiki, John G Yovos
BACKGROUND: Circulating microRNAs (miRs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. AIM: The aim of this study was to investigate serum levels of specific microRNAs, known regulators of bone metabolism, in postmenopausal women with low bone mass and with or without vertebral fractures (VFs). METHODS: For the analysis, 14 miRs were isolated from the serum of 35 postmenopausal women with low bone mass and with at least one moderate VF and 35 postmenopausal women with low bone mass without fractures...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27797453/mature-neurons-dynamically-restrict-apoptosis-via-redundant-premitochondrial-brakes
#12
Ryan P Annis, Vijay Swahari, Ayumi Nakamura, Alison X Xie, Scott M Hammond, Mohanish Deshmukh
Apoptotic cell death is critical for the early development of the nervous system, but once the nervous system is established, the apoptotic pathway becomes highly restricted in mature neurons. However, the mechanisms underlying this increased resistance to apoptosis in these mature neurons are not completely understood. We have previously found that members of the miR-29 family of microRNAs (miRNAs) are induced with neuronal maturation and that overexpression of miR-29 was sufficient to restrict apoptosis in neurons...
December 2016: FEBS Journal
https://www.readbyqxmd.com/read/27765762/microrna-29c-regulates-apoptosis-sensitivity-via-modulation-of-the-cell-surface-death-receptor-fas-in-lung-fibroblasts
#13
Shingo Matsushima, Junichi Ishiyama
MicroRNAs play an important role in the development and progression of various diseases, such as idiopathic pulmonary fibrosis (IPF). Although the accumulation of aberrant fibroblasts resistant to apoptosis is a hallmark in IPF lungs, the mechanism regulating apoptosis susceptibility is not fully understood. Here, we investigated the role of miR-29, which is the most downregulated microRNA in IPF lungs and is also known as a regulator of extracellular matrix (ECM), in the mechanism of apoptosis resistance. We found that functional inhibition of miR-29c caused resistance to Fas-mediated apoptosis in lung fibroblasts...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27691978/the-role-of-microrna-in-ischemic-and-hemorrhagic-stroke
#14
Jolana Lipkova, Kamil Duris
BACKGROUND: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. METHODS: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies...
19, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27666438/disruption-of-a-mir-29-binding-site-leading-to-col4a1-upregulation-causes-pontine-autosomal-dominant-microangiopathy-with-leukoencephalopathy
#15
Edgard Verdura, Dominique Hervé, Françoise Bergametti, Clémence Jacquet, Typhaine Morvan, Carol Prieto-Morin, Alexandre Mackowiak, Eric Manchon, Hassan Hosseini, Charlotte Cordonnier, Isabelle Girard-Buttaz, Sophie Rosenstingl, Christian Hagel, Gregor Kuhlenbaümer, Elena Leca-Radu, Didier Goux, Lauren Fleming, Tom Van Agtmael, Hugues Chabriat, Françoise Chapon, Elisabeth Tournier-Lasserve
OBJECTIVE: Cerebral small vessel disease (cSVD) is a heterogeneous group of disorders. Screening of known cSVD genes identifies the causative mutation in <15% of familial cSVD cases. We sought to identify novel causes of cSVD. METHODS: We used linkage analysis and exome sequencing to identify the causal mutation in a French cSVD family. The identified candidate gene was then screened in 202 cSVD unrelated probands, including 1 proband from the first reported pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL) family...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27649654/targeting-mir-29-induces-apoptosis-of-osteosarcoma-mg-63-cells-via-regulation-of-tgf-%C3%AE-1-puma-signal
#16
C-Y Wang, J-B Ren, M Liu, L Yu
OBJECTIVE: Recent studies have shown that high miR-29 expression was associated with poor prognosis in patients with osteosarcoma (OS). However, the exact role and mechanisms of miR-29 in human OS remains speculative. Here, we identify a connection between miR-29 and TGF-β1/PUMA signaling in this context. PATIENTS AND METHODS: MG-63 cells were treated with anti-miR-29 for 48 h. Cell growth and apoptosis in vitro were detected by MTT, colony formation and flow cytometry assay...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27648733/controllable-large-scale-transfection-of-primary-mammalian-cardiomyocytes-on-a-nanochannel-array-platform
#17
Lingqian Chang, Daniel Gallego-Perez, Chi-Ling Chiang, Paul Bertani, Tairong Kuang, Yan Sheng, Feng Chen, Zhou Chen, Junfeng Shi, Hao Yang, Xiaomeng Huang, Veysi Malkoc, Wu Lu, Ly James Lee
While electroporation has been widely used as a physical method for gene transfection in vitro and in vivo, its application in gene therapy of cardiovascular cells remains challenging. Due to the high concentration of ion-transport proteins in the sarcolemma, conventional electroporation of primary cardiomyocytes tends to cause ion-channel activation and abnormal ion flux, resulting in low transfection efficiency and high mortality. In this work, a high-throughput nanoelectroporation technique based on a nanochannel array platform is reported, which enables massively parallel delivery of genetic cargo (microRNA, plasmids) into mouse primary cardiomyocytes in a controllable, highly efficient, and benign manner...
November 2016: Small
https://www.readbyqxmd.com/read/27630617/the-ticking-of-the-epigenetic-clock-antipsychotic-drugs-in-old-age
#18
Adonis Sfera, Carolina Osorio, Luzmin Inderias, Michael Cummings
BACKGROUND: Exposed to antipsychotic drugs (APDs), older individuals with dementing illness are at risk of cerebrovascular adverse effects (CVAE), including sudden death. Transient microvascular dysfunctions are known to occur in younger persons exposed to APDs; however, they seldom progress to CVAE, suggesting that APDs alone are insufficient for engendering this untoward effect. It is, therefore, believed that a preexistent microvascular damage is necessary for CVAE to take place, but the exact nature of this lesion remains unclear...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27627870/pregnancy-driven-cardiovascular-maternal-mir-29-plasticity-in-obesity
#19
N Schlabritz-Loutsevitch, K Apostolakis-Kyrus, R Krutilina, G Hubbard, M Kocak, Z Janjetovic, S Sathanandam, A T Slominski, G Mari, E Dick
BACKGROUND: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. METHODS: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation...
September 15, 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27626694/novel-role-of-mir-29a-in-pancreatic-cancer-autophagy-and-its-therapeutic-potential
#20
Jason J Kwon, Jeffrey A Willy, Kayla A Quirin, Ronald C Wek, Murray Korc, Xiao-Ming Yin, Janaiah Kota
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal malignancy that responds poorly to current therapeutic modalities. In an effort to develop novel therapeutic strategies, we found downregulation of miR-29 in pancreatic cancer cells, and overexpression of miR-29a sensitized chemotherapeutic resistant pancreatic cancer cells to gemcitabine, reduced cancer cell viability, and increased cytotoxicity. Furthermore, miR-29a blocked autophagy flux, as evidenced by an accumulation of autophagosomes and autophagy markers, LC3B and p62, and a decrease in autophagosome-lysosome fusion...
September 10, 2016: Oncotarget
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