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miR-29

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https://www.readbyqxmd.com/read/29318382/mir-29-silencing-modulates-the-expression-of-target-genes-related-to-proliferation-apoptosis-and-methylation-in-burkitt-lymphoma-cells
#1
Luciano Mazzoccoli, Marcela Cristina Robaina, Alexandre Gustavo Apa, Martin Bonamino, Luciana Wernersbach Pinto, Eduardo Queiroga, Carlos E Bacchi, Claudete Esteves Klumb
PURPOSE: Burkitt lymphoma (BL) is a B-cell lymphoma frequently diagnosed in children. It is characterized by MYC translocations, which lead to the constitutive expression of the MYC oncogene. MYC contributes to miR-29 repression through an E-box MYC binding site on the miR-29b-1/miR-29a promoter region. We evaluated the role of miR-29a/b/c and their predicted targets in BL pathogenesis. METHODS: Mature sequences of miR-29a/b/c were transfected to the BL cell lines BL41 and Raji, and evaluated for DNMT3B, MCL1, BIM, CDK6, AKT and TCL1 protein expression as well as for MCL-1 and CDK6 mRNA expression...
January 9, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29258985/recent-advances-on-the-role-of-long-non-coding-rna-h19-in-regulating-mammalian-muscle-growth-and-development
#2
Chen Yu Qin, He Cai, Han Rui Qing, Li Li, Hong Ping Zhang
As one of the first identified long non-coding RNAs (lncRNAs), H19 plays a wide range of roles in vivo, including not only as a tumor suppressor and oncogene involved in disease process, but also as a regulator of growth and development of multiple tissues in mammalian embryos. The function of H19 in muscles (both skeletal and cardiac muscle) draws widespread attention due to the following two reasons. On one hand, H19 promotes myogenic differentiation and myogenesis of skeletal muscle satellite cells (SMSCs) via regulating Igf2 in cis...
December 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29230533/regulation-of-type-i-collagen-expression-by-microrna-29-following-ionizing-radiation
#3
Hiroyuki Yano, Ryoji Hamanaka, Miki Nakamura-Ota, Juan Juan Zhang, Noritaka Matsuo, Hidekatsu Yoshioka
Radiation-induced fibrosis (RIF) is thought to involve the excessive accumulation of collagen and other extracellular matrix components; previously, we reported that ionizing radiation increased the type I collagen expression and that transforming growth factor (TGF)-β was involved in this increase through activating its downstream mediator, Smad3. A recent study found that microRNAs (miRNAs)-small, noncoding sequences approximately 20 nucleotides long-negatively regulate the gene expression posttranscriptionally, and it has been suggested that miRNAs play essential roles in cellular processes, including fibrosis...
December 11, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29216763/upregulated-mir-29c-suppresses-silica-induced-lung-fibrosis-through-the-wnt-%C3%AE-catenin-pathway-in-mice
#4
X Wang, K Xu, X Y Yang, J Liu, Q Zeng, F S Wang
Silicosis is an irreversible lung disease resulting from long-term inhalation of occupational dust containing silicon dioxide. However, the pathogenesis of silicosis has not been clearly understood yet. Accumulating evidence suggests that miR-29 may have a significant anti-fibrotic capacity, meanwhile it may relate to Wnt/β-catenin pathway. The purpose of this study was to discuss the role of miR-29 in the progression of silicosis. A lentiviral vector was constructed, named Lv-miR-29c, which was overexpressing miR-29c...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29207141/downregulation-of-mir%C3%A2-29b-targets-dnmt3b-to-suppress-cellular-apoptosis-and-enhance-proliferation-in-pancreatic-cancer
#5
Li-Hua Wang, Ju Huang, Cheng-Rong Wu, Liu-Ye Huang, Jun Cui, Zhi-Zhi Xing, Chun-Yu Zhao
As one of the most aggressive types of tumor, pancreatic cancer is a principal cause of tumor‑associated mortality. Negative associations between microRNA‑29 (miR‑29) and DNA methyltransferases (DNMT) 3a and 3b have been demonstrated to be associated with the carcinogenesis of a number of types of cancer; however, this has not been completely elucidated in pancreatic cancer. In the present study, pancreatic cancer tissues (n=15) and corresponding paracancerous tissues (n=15) were obtained and the results of reverse transcription‑quantitative polymerase chain reaction analysis indicated decreased expression of miR‑29b and enhanced mRNA expression of DNMT3b in pancreatic cancer tissues, compared with the corresponding paracancerous tissues...
November 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203887/age-dependent-increase-of-oxidative-stress-regulates-microrna-29-family-preserving-cardiac-health
#6
Johanna Heid, Chiara Cencioni, Roberto Ripa, Mario Baumgart, Sandra Atlante, Giuseppina Milano, Alessandro Scopece, Carsten Kuenne, Stefan Guenther, Valerio Azzimato, Antonella Farsetti, Giacomo Rossi, Thomas Braun, Giulio Pompilio, Fabio Martelli, Andreas M Zeiher, Alessandro Cellerino, Carlo Gaetano, Francesco Spallotta
The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 week (young), 12-21 week (adult) and 28-40 week (old) Nfu hearts revealed 23 up-regulated and 18 down-regulated miRNAs with age. MiR-29 family turned out as one of the most up-regulated miRNAs during aging. MiR-29 family increase induces a decrease of known targets like collagens and DNA methyl transferases (DNMTs) paralleled by 5´methyl-cytosine (5mC) level decrease...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192829/the-lung-likes-the-little-fella-mir-29
#7
Gang Liu, Victor J Thannickal
No abstract text is available yet for this article.
December 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#8
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
January 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29176935/restoration-of-mir-29b-exerts-anti-cancer-effects-on-glioblastoma
#9
Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim, Chul-Kee Park
Background: Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 subfamilies are known to be exclusively expressed in the developing brain, and they are aberrantly down-regulated in GBM. This study aims to elucidate the role of miR-29b in GBM development and the feasibility of therapeutic targeting using conjugated nanoparticles. Methods: After confirmation of miR-29b expression levels in GBM tissues by analysis of open source data, the anticancer effect of miR-29b was tested by the introduction of syn-hsa-miR-29b-3p in the A172 GBM cell line...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29164615/arhgef19-interacts-with-braf-to-activate-mapk-signaling-during-the-tumorigenesis-of-non-small-cell-lung-cancer
#10
Yingchang Li, Zhihua Ye, Shuai Chen, Zhiwen Pan, Qianghua Zhou, Yi-Zhuo Li, Wen-di Shuai, Chun-Mei Kuang, Qi-Hua Peng, Wei Shi, Xueli Mao, Ran-Yi Liu, Wenlin Huang
Rho guanine nucleotide exchange factors (RhoGEFs) are proteins that activate Rho GTPases in response to extracellular stimuli and regulate various biologic processes. ARHGEF19, one of RhoGEFs, was reported to activate RhoA in the Wnt-PCP pathway controlling convergent extension in Xenopus gastrulation. The goal of this study was to identify the role and molecular mechanisms of ARHGEF19 in the tumorigenesis of non-small cell lung cancer (NSCLC). ARHGEF19 expression was significantly elevated in NSCLC tissues, and ARHGEF19 levels were significantly associated with lymph node status, distant metastasis and TNM stage; Patients with high ARHGEF19 levels had poor overall survival (OS) and progression-free survival (PFS)...
November 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29158499/cardiac-myocyte-mir-29-promotes-pathological-remodeling-of-the-heart-by-activating-wnt-signaling
#11
Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function in fibroblasts. Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocytes and overall cardiac dysfunction. In a mouse model of cardiac pressure overload, global genetic deletion of miR-29 or antimiR-29 infusion prevents cardiac hypertrophy and fibrosis and improves cardiac function...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29113367/micrornas-with-prognostic-significance-in-osteosarcoma-a-systemic-review-and-meta-analysis
#12
Dong Cheng, Xubin Qiu, Ming Zhuang, Chenlei Zhu, Hongjun Zou, Zhiwei Liu
Introduction: This study aimed to elucidate the prognostic value of microRNAs (miRNAs) in patients with osteosarcoma. Materials and Methods: Studies were recruited by searching PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang data-bases (final search update conducted January 2017). Eligible studies were identified and the quality was assessed using multiple search strategies. Results: A total of 55 articles that investigated the correlation between miRNA expression and either patient survival or disease recurrence in osteosarcoma was initially identified...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044773/integrated-analysis-of-microrna-and-mrna-expression-profiles-in-the-rat-spinal-cord-under-inflammatory-pain-conditions
#13
Chien Cheng Liu, Jiin Tsuey Cheng, Tien Yui Li, Ping Heng Tan
Recent studies using microarray-based approaches have demonstrated that microRNAs (miRNAs) are involved in pain processing pathways. However, a significant proportion of computational predictions of miRNA targets are false-positive interactions. To increase the chance of identifying biologically relevant targets, we performed an integrated analysis of both miRNA and mRNA expression profiles in the rat spinal cord during complete Freund's adjuvant (CFA)-induced inflammatory pain. We generated miRNA and mRNA arrays from the same corresponding samples on Days 5 and 14 after CFA injection...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29023945/microrna-29a-inhibits-proliferation-and-motility-of-schwannoma-cells-by-targeting-cdk6
#14
Ji Ma, Tengfei Li, Huifeng Yuan, Xinwei Han, Shaofeng Shui, Dong Guo, Lei Yan
AIM: MicroRNA-29 (miR-29)family involved in various types of cancer regulation. Although miR-29a was shown to play an inhibitory role in tumorigenesis, the effect of miR-29a expression on schwannoma cells still remains unclear. In this study, we aimed to explore the role of miR-29a in schwannoma. METHODS: The expressions of miR-29a, miR-29b and miR-29c were detected in the Schwann tissues and cell lines using qRT-PCR. The effect of miR-29a, miR-29b and miR-29c on cell viability, migration, invasion and apoptosis was tested...
October 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28988362/mir-29b-mimics-promotes-cell-apoptosis-of-smooth-muscle-cells-via-targeting-on-mmp-2
#15
Lingguang Shen, Yanhui Song, Yuqin Fu, Peipei Li
The phenotypic transformation and dysfunctions of vascular smooth muscle cells (SMCs) such as abnormality proliferation and apoptosis are key pathological basis of atherosclerosis. The recent study aimed to detect the role of miR-29b in phenotypic transformation of SMCs. In this study, we investigated the expression level of miR-29b and MMP-2 in acute coronary syndrome (ACS) patients, verified whether MMP-2 is the target gene of miR-29b by luciferase reporter gene system, and explored the role of miR-29b in the viability and apoptosis of SMCs...
October 7, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28979765/micrornas-in-the-development-and-neoplasia-of-the-mammary-gland
#16
REVIEW
Manoj Kumar Jena
Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation...
2017: F1000Research
https://www.readbyqxmd.com/read/28926107/fenofibrate-reverses-changes-induced-by-high-fat-diet-on-metabolism-in-mice-muscle-and-visceral-adipocytes
#17
Flávia de Toledo Frias, Karina Cunha E Rocha, Mariana de Mendonça, Gilson Massahiro Murata, Hygor Nunes Araujo, Luís Gustavo Oliveira de Sousa, Érica de Souza, Sandro Massao Hirabara, Nayara de Carvalho Leite, Everardo Magalhães Carneiro, Rui Curi, Leonardo Reis Silveira, Alice Cristina Rodrigues
The effect of fenofibrate on the metabolism of skeletal muscle and visceral white adipose tissue of diet-induced obese (DIO) mice was investigated. C57BL/6J male mice were fed either a control or high-fat diet for eight weeks. Fenofibrate (50 mg/Kg b.w., daily) was administered by oral gavage during the last two weeks of the experimental period. Insulin-stimulated glucose metabolism in soleus muscles, glucose tolerance test, insulin tolerance test, indirect calorimetry, lipolysis of visceral white adipose tissue, expression of miR-103-3p in adipose tissue and miR-1a, miR-133a/b, miR-206, let7b-5p, miR-23b-3p, miR-29-3p, miR-143-3p in soleus muscle, genes related to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were investigated...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28918029/activation-of-ampk-attenuated-cardiac-fibrosis-by-inhibiting-cdk2-via-p21-p27-and-mir-29-family-pathways-in-rats
#18
Hanping Qi, Yan Liu, Shuzhi Li, Yunping Chen, Lei Li, Yonggang Cao, Mingyao E, Pilong Shi, Chao Song, Baiyan Li, Hongli Sun
Cardiac fibrosis is pathological damage associated with nearly all forms of heart disease. AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme. Emerging evidences indicate that AMPK plays an important role in cardiac fibrosis and cell proliferation. However, less is known about the detailed mechanism of AMPK activation on cardiac fibrosis. In this study, we found the AMPK activation improved the impaired cardiac function of cardiac fibrosis rats and decreased interstitial fibrosis...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28902861/epigenetic-regulation-of-metalloproteinases-and-their-inhibitors-in-rotator-cuff-tears
#19
Mariana Ferreira Leal, Leonardo Caires Dos Santos, Adrielle Martins de Oliveira, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Carina Cohen, Felipe de Seixas Alves, Wânia Hiromi Yanaguizawa, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman, Marília Cardoso Smith, Maria Teresa de Seixas Alves, Moises Cohen
Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion...
2017: PloS One
https://www.readbyqxmd.com/read/28883017/nf%C3%AE%C2%BAb-signaling-in-alveolar-rhabdomyosarcoma
#20
Megan M Cleary, Atiya Mansoor, Teagan Settelmeyer, Yuichi Ijiri, Katherine J Ladner, Matthew N Svalina, Brian P Rubin, Denis C Guttridge, Charles Keller
Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches. In aRMS, the NFκB-YY1-miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor suppressor activity. To further elucidate the role of NFκB in aRMS, we first tested 55 unique sarcoma cell lines and primary cell cultures in a large-scale chemical screen targeting diverse molecular pathways...
September 1, 2017: Disease Models & Mechanisms
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