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https://www.readbyqxmd.com/read/27924640/the-association-of-circulating-mir-30a-mir-29-and-mir-133-with-white-coat-hypertension
#1
Yu-Qing Huang, Cheng Huang, Ji-Yan Chen, Jie Li, Ying-Qing Feng
AIM: The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD: Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The area under the receiver-operating characteristic curve was used to evaluate diagnostic accuracy. RESULTS: MiR-30a yielded an AUC of 0...
December 7, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27922664/expression-of-bcl-2-and-micrornas-in-cardiac-tissues-of-patients-with-dilated-cardiomyopathy
#2
Yong Wang, Min Li, Li Xu, Ju Liu, Dong Wang, Quan Li, Lili Wang, Peijie Li, Shanliang Chen, Tianqi Liu
Dilated cardiomyopathy (DCM) is associated with sudden cardiac death and heart failure, resulting in a significant medical burden. The mechanisms underlying the pathogenesis of DCM remain elusive. In the present study, human cardiac tissues from patients with DCM and healthy donors were collected and their pathology was examined. The expression levels of apoptosis regulator Bcl-2 and fibrosis-associated microRNAs were also evaluated. Extensive myocardial fibrosis and apoptosis in DCM cardiac tissues was observed...
December 2, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27916417/ccl20-ccr6-promotes-cell-proliferation-and-metastasis-in-laryngeal-cancer-by-activating-p38-pathway
#3
Eryong Lu, Jili Su, Yanhui Zhou, Chao Zhang, Yuehui Wang
Chemokine and its receptors play important roles in laryngeal cancer development and progression. CCR6 is the receptor of CCL20 chemokine, but its function in laryngeal cancer is not known. The aim of this study is to explore the roles of CCR6 and its regulation mechanism in laryngeal cancer. We found CCR6 expression was higher in laryngeal cancer tissues compared with their normal controls, so did in laryngeal cancer cells. Cellular function indicated that down-regulation of CCR6 in laryngeal cancer cells could suppress cell proliferation and metastasis...
December 1, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27889210/relations-between-circulating-micrornas-mir-21-mir-26-mir-29-mir-30-and-mir-133a-extracellular-matrix-fibrosis-and-serum-markers-of-fibrosis-in-dilated-cardiomyopathy
#4
Paweł Rubiś, Justyna Totoń-Żurańska, Sylwia Wiśniowska-Śmiałek, Katarzyna Holcman, Maria Kołton-Wróż, Paweł Wołkow, Ewa Wypasek, Joanna Natorska, Lucyna Rudnicka-Sosin, Agnieszka Pawlak, Artur Kozanecki, Piotr Podolec
No abstract text is available yet for this article.
November 18, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27836951/expression-of-micrornas-that-regulate-bone-turnover-in-the-serum-of-postmenopausal-women-with-low-bone-mass-and-vertebral-fractures
#5
Maria P Yavropoulou, Athanasios D Anastasilakis, Polyzois Makras, Dimitrios G Tsalikakis, Maria Grammatiki, John G Yovos
BACKGROUND: Circulating microRNAs (miRs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. AIM: The aim of this study was to investigate serum levels of specific microRNAs, known regulators of bone metabolism, in postmenopausal women with low bone mass and with or without vertebral fractures (VFs). METHODS: For the analysis, 14 miRs were isolated from the serum of 35 postmenopausal women with low bone mass and with at least one moderate VF and 35 postmenopausal women with low bone mass without fractures...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27797453/mature-neurons-dynamically-restrict-apoptosis-via-redundant-pre-mitochondrial-brakes
#6
Ryan P Annis, Vijay Swahari, Ayumi Nakamura, Alison X Xie, Scott M Hammond, Mohanish Deshmukh
Apoptotic cell death is critical for the early development of the nervous system, but once the nervous system is established, the apoptotic pathway becomes highly restricted in mature neurons. However, the mechanisms underlying this increased resistance to apoptosis in these mature neurons are not completely understood. We have previously found that members of the miR-29 family of microRNAs (miRNAs) are induced with neuronal maturation and that overexpression of miR-29 was sufficient to restrict apoptosis in neurons...
October 31, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27765762/microrna-29c-regulates-apoptosis-sensitivity-via-modulation-of-the-cell-surface-death-receptor-fas-in-lung-fibroblasts
#7
Shingo Matsushima, Junichi Ishiyama
MicroRNAs play an important role in the development and progression of various diseases, such as idiopathic pulmonary fibrosis (IPF). Although the accumulation of aberrant fibroblasts resistant to apoptosis is a hallmark in IPF lungs, the mechanism regulating apoptosis susceptibility is not fully understood. Here, we investigated the role of miR-29, which is the most downregulated microRNA in IPF lungs and is also known as a regulator of extracellular matrix (ECM), in the mechanism of apoptosis resistance. We found that functional inhibition of miR-29c caused resistance to Fas-mediated apoptosis in lung fibroblasts...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27691978/the-role-of-microrna-in-ischemic-and-hemorrhagic-stroke
#8
Kamil Duris, Jolana Lipkova
BACKGROUND: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. METHODS: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies...
September 19, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27666438/disruption-of-a-mir-29-binding-site-leading-to-col4a1-upregulation-causes-pontine-autosomal-dominant-microangiopathy-with-leukoencephalopathy
#9
Edgard Verdura, Dominique Hervé, Françoise Bergametti, Clémence Jacquet, Typhaine Morvan, Carol Prieto-Morin, Alexandre Mackowiak, Eric Manchon, Hassan Hosseini, Charlotte Cordonnier, Isabelle Girard-Buttaz, Sophie Rosenstingl, Christian Hagel, Gregor Kuhlenbaümer, Elena Leca-Radu, Didier Goux, Lauren Fleming, Tom Van Agtmael, Hugues Chabriat, Françoise Chapon, Elisabeth Tournier-Lasserve
OBJECTIVE: Cerebral small vessel disease (cSVD) is a heterogeneous group of disorders. Screening of known cSVD genes identifies the causative mutation in <15% of familial cSVD cases. We sought to identify novel causes of cSVD. METHODS: We used linkage analysis and exome sequencing to identify the causal mutation in a French cSVD family. The identified candidate gene was then screened in 202 cSVD unrelated probands, including 1 proband from the first reported pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL) family...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27649654/targeting-mir-29-induces-apoptosis-of-osteosarcoma-mg-63-cells-via-regulation-of-tgf-%C3%AE-1-puma-signal
#10
C-Y Wang, J-B Ren, M Liu, L Yu
OBJECTIVE: Recent studies have shown that high miR-29 expression was associated with poor prognosis in patients with osteosarcoma (OS). However, the exact role and mechanisms of miR-29 in human OS remains speculative. Here, we identify a connection between miR-29 and TGF-β1/PUMA signaling in this context. PATIENTS AND METHODS: MG-63 cells were treated with anti-miR-29 for 48 h. Cell growth and apoptosis in vitro were detected by MTT, colony formation and flow cytometry assay...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27648733/controllable-large-scale-transfection-of-primary-mammalian-cardiomyocytes-on-a-nanochannel-array-platform
#11
Lingqian Chang, Daniel Gallego-Perez, Chi-Ling Chiang, Paul Bertani, Tairong Kuang, Yan Sheng, Feng Chen, Zhou Chen, Junfeng Shi, Hao Yang, Xiaomeng Huang, Veysi Malkoc, Wu Lu, Ly James Lee
While electroporation has been widely used as a physical method for gene transfection in vitro and in vivo, its application in gene therapy of cardiovascular cells remains challenging. Due to the high concentration of ion-transport proteins in the sarcolemma, conventional electroporation of primary cardiomyocytes tends to cause ion-channel activation and abnormal ion flux, resulting in low transfection efficiency and high mortality. In this work, a high-throughput nanoelectroporation technique based on a nanochannel array platform is reported, which enables massively parallel delivery of genetic cargo (microRNA, plasmids) into mouse primary cardiomyocytes in a controllable, highly efficient, and benign manner...
September 20, 2016: Small
https://www.readbyqxmd.com/read/27630617/the-ticking-of-the-epigenetic-clock-antipsychotic-drugs-in-old-age
#12
Adonis Sfera, Carolina Osorio, Luzmin Inderias, Michael Cummings
BACKGROUND: Exposed to antipsychotic drugs (APDs), older individuals with dementing illness are at risk of cerebrovascular adverse effects (CVAE), including sudden death. Transient microvascular dysfunctions are known to occur in younger persons exposed to APDs; however, they seldom progress to CVAE, suggesting that APDs alone are insufficient for engendering this untoward effect. It is, therefore, believed that a preexistent microvascular damage is necessary for CVAE to take place, but the exact nature of this lesion remains unclear...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27627870/pregnancy-driven-cardiovascular-maternal-mir-29-plasticity-in-obesity
#13
N Schlabritz-Loutsevitch, K Apostolakis-Kyrus, R Krutilina, G Hubbard, M Kocak, Z Janjetovic, S Sathanandam, A T Slominski, G Mari, E Dick
BACKGROUND: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. METHODS: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation...
September 15, 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27626694/novel-role-of-mir-29a-in-pancreatic-cancer-autophagy-and-its-therapeutic-potential
#14
Jason J Kwon, Jeffrey A Willy, Kayla A Quirin, Ronald C Wek, Murray Korc, Xiao-Ming Yin, Janaiah Kota
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal malignancy that responds poorly to current therapeutic modalities. In an effort to develop novel therapeutic strategies, we found downregulation of miR-29 in pancreatic cancer cells, and overexpression of miR-29a sensitized chemotherapeutic resistant pancreatic cancer cells to gemcitabine, reduced cancer cell viability, and increased cytotoxicity. Furthermore, miR-29a blocked autophagy flux, as evidenced by an accumulation of autophagosomes and autophagy markers, LC3B and p62, and a decrease in autophagosome-lysosome fusion...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27536362/biomarkers-of-intestinal-fibrosis-one-step-towards-clinical-trials-for-stricturing-inflammatory-bowel-disease
#15
REVIEW
Paolo Giuffrida, Massimo Pinzani, Gino R Corazza, Antonio Di Sabatino
Intestinal fibrosis, caused by an excessive deposition of extracellular matrix components, and subsequent stricture development are a common complication of inflammatory bowel disease. However, currently there are no biomarkers which reliably predict the risk of developing intestinal strictures or identify early stages of fibrosis prior to clinical symptoms. Candidate biomarkers of intestinal fibrosis, including gene variants (i.e. nucleotide-binding oligomerization domain-2 gene), serum microRNAs (miR-19, miR-29), serum extracellular matrix proteins (i...
August 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27513203/molecular-cloning-expression-analysis-and-mirna-prediction-of-vascular-endothelial-growth-factor-a-vegfaa-and-vegfab-in-pond-loach-misgurnus-anguillicaudatus-an-air-breathing-fish
#16
Weiwei Luo, Xiao Liang, Songqian Huang, Xiaojuan Cao
Vascular endothelial growth factor A (VEGFA) is the most studied and the best characterized member of the VEGF family and is a key regulator of angiogenesis via its ability to affect the proliferation, migration, and differentiation of endothelial cells. In this study, the full-length cDNAs encoding VEGFAa and VEGFAb from pond loach, Misgurnus anguillicaudatus, were isolated. The VEGFAa is constituted by an open reading frame (ORF) of 570bp encoding for a peptide of 189 amino acid residues, a 639bp 5'-untranslated region (UTR) and a 2383bp 3' UTR...
August 8, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27490049/microrna-29b-overexpression-decreases-extracellular-matrix-mrna-and-protein-production-in-human-corneal-endothelial-cells
#17
Tetsuya Toyono, Tomohiko Usui, Guadalupe Villarreal, Laura Kallay, Mario Matthaei, Lucas M M Vianna, Angela Y Zhu, Masahiko Kuroda, Shiro Amano, Albert S Jun
PURPOSE: MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level. We reported that levels of microRNA (miR)-29 family are decreased in corneas of patients with Fuchs endothelial corneal dystrophy (FECD). The miR-29 family regulates the production of extracellular matrix (ECM) proteins. Accumulation of ECM proteins in Descemet membrane is an important pathologic change in FECD. In this study, we transfected miR-29b into human corneal endothelial cells and tissues and evaluated ECM protein expression levels...
November 2016: Cornea
https://www.readbyqxmd.com/read/27477273/feedback-loop-regulation-of-scap-srebp-1-by-mir-29-modulates-egfr-signaling-driven-glioblastoma-growth
#18
Peng Ru, Peng Hu, Feng Geng, Xiaokui Mo, Chunming Cheng, Ji Young Yoo, Xiang Cheng, Xiaoning Wu, Jeffrey Yunhua Guo, Ichiro Nakano, Etienne Lefai, Balveen Kaur, Arnab Chakravarti, Deliang Guo
Dysregulated lipid metabolism is a characteristic of malignancies. Sterol regulatory element binding protein 1 (SREBP-1), a transcription factor playing a central role in lipid metabolism, is highly activated in malignancies. Here, we unraveled a link between miR-29 and the SCAP (SREBP cleavage-activating protein)/SREBP-1 pathway in glioblastoma (GBM) growth. Epidermal growth factor receptor (EGFR) signaling enhances miR-29 expression in GBM cells via upregulation of SCAP/SREBP-1, and SREBP-1 activates miR-29 expression via binding to specific sites in its promoter...
August 9, 2016: Cell Reports
https://www.readbyqxmd.com/read/27460729/bioinformatic-analysis-of-rna-seq-data-unveiled-critical-genes-in-rectal-adenocarcinoma
#19
Z-G Zuo, X-F Zhang, X-Z Ye, Z-H Zhou, X-B Wu, S-C Ni, H-Y Song
OBJECTIVE: RNA-seq data of rectal adenocarcinoma (READ) were analyzed with bioinformatics tools to unveil potential biomarkers in the disease. MATERIALS AND METHODS: RNA-seq data of READ were downloaded from The Cancer Genome Atlas (TCGA) database. Differential analysis was performed with package edgeR. False discovery rate (FDR) < 0.05 and |log2 (fold change)|>1 were set as cut-off values to screen out differentially expressed genes (DEGs). Gene coexpression network was constructed with package Ebcoexpress...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27449105/mir-29-regulates-tet1-expression-and-contributes-to-early-differentiation-of-mouse-escs
#20
Yanhua Cui, Ting Li, Dehua Yang, Song Li, Weidong Le
The ten-eleven translocation-1 (Tet1), which converts 5-methylcytosine (5mC) to 5-hydroxymethycytosine (5hmC), plays important roles in many important biological processes, such as mouse embryonic stem cells (ESCs) maintenance. However, the mechanisms for Tet-1 regulation remain largely unknown. Here we showed that miR-29 family (miR-29a, miR-29b and miR-29c) can directly repress Tet1 expression. We found that Tet1 was highly expressed and 5hmC was presented at relatively high levels in mouse ESCs, but the levels of both Tet1 and 5hmC were reduced during the early differentiation of ESCs...
July 21, 2016: Oncotarget
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