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https://www.readbyqxmd.com/read/29613981/phacomorphic-angle-closure-following-silicone-oil-tamponade-in-a-pediatric-patient
#1
Victoria C Leung, Simon Fung, Rajeev Muni, Asim Ali
PURPOSE: To report a case of phacomorphic glaucoma following retinal detachment repair with silicone oil in a pediatric patient. STUDY DESIGN: Case report. METHODS: A chart review was conducted at St. Michael's Hospital and The Hospital for Sick Children (Toronto, Canada), where the patient received ophthalmic care from July 28, 2015 onwards. RESULTS: A 14 year-old boy with a history of traumatic retinal detachment and proliferative vitreoretinopathy in the left eye, requiring two pars plana vitrectomies, membrane peel, and silicone oil tamponade, presented with one-day history of decreased vision in the left eye, severe headache, nausea, and vomiting...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29608155/primary-cell-cultures-from-the-mouse-retinal-pigment-epithelium
#2
Peng Shang, Nadezda A Stepicheva, Stacey Hose, J Samuel Zigler, Debasish Sinha
The retinal pigment epithelium (RPE) is a highly polarized multi-functional epithelium that is located between the neural retina and the choroid of the eye. It is a single sheet of pigmented cells that are hexagonally packed and connected by tight junctions. The main functions of the RPE include absorption of light, phagocytosis of the shed photoreceptor outer segments, spatial buffering of ions, transport of nutrients, ions and water as well as active involvement in the visual cycle. With such important and diverse functions, it is critically important to study the biology of RPE cells...
March 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29578200/epigallocatechin-gallate-curcumin-prevent-transforming-growth-factor-beta-1-induced-epithelial-to-mesenchymal-transition-in-arpe-19-cells
#3
Sivasankar Shanmuganathan, Venil N Sumantran, Narayanasamy Angayarkanni
Background & objectives: Proliferative vitreoretinopathy (PVR) is characterized by the presence of epiretinal membrane (ERM), which exerts traction and detaches the retina. Epithelial to mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells underlies ERM formation. Adjuvant therapies aimed at preventing recurrence of PVR after surgery mostly failed in clinical trials. This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-β1) in cultured ARPE-19 cells...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29538592/comparisons-of-retinal-nerve-fiber-layer-thickness-changes-after-macular-hole-surgery
#4
Nelson Chamma Capelanes, André Vasconcellos Diniz, Érika Pacheco Magalhães, Karise de Oliveira Marques
PURPOSE: To compare postoperative changes in retinal nerve fiber layer thickness in patients with macular holes treated with vitrectomy with Brilliant Blue-assisted internal limiting membrane peeling. METHODS: Twenty-two eyes of 20 patients with macular holes were studied. Each eye was selected to undergo Brilliant Blue-assisted internal limiting membrane peeling. The circumferential retinal nerve fiber layer thickness was determined using spectral domain optical coherence tomography preoperatively and 2 months postoperatively...
January 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29443358/microscope-integrated-intraoperative-ultrahigh-speed-swept-source-optical-coherence-tomography-for-widefield-retinal-and-anterior-segment-imaging
#5
Chen D Lu, Nadia K Waheed, Andre Witkin, Caroline R Baumal, Jonathan J Liu, Benjamin Potsaid, Anthony Joseph, Vijaysekhar Jayaraman, Alex Cable, Kinpui Chan, Jay S Duker, James G Fujimoto
BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29440740/boston-keratoprosthesis-type-1-outcomes-of-the-first-38-cases-performed-at-moorfields-eye-hospital
#6
Chameen Samarawickrama, Nicholas Strouthidis, Mark R Wilkins
PURPOSE: To evaluate outcomes of Boston keratoprosthesis type 1 (K-Pro) surgery in a cohort of high-risk patients at Moorfields Eye Hospital. Our patients were referred to us at the end-point of their ocular disease. METHODS: A retrospective review of all K-Pro surgery performed between March 2011 and July 2015 with a minimum follow-up of 12 months. RESULTS: 39 eyes of 38 patients were included. Mean follow-up was 28.4 months (range: 12-56)...
February 14, 2018: Eye
https://www.readbyqxmd.com/read/29366625/involvement-of-mglur-i-in-ephb-ephrinb-reverse-signaling-activation-induced-retinal-ganglion-cell-apoptosis-in-a-rat-chronic-hypertension-model
#7
Yuan Zhao, Qian Li, Xue-Yan Li, Peng Cui, Feng Gao, Ke Zhu, Ling-Zhu Li, Xing-Huai Sun, Zhongfeng Wang
EphB/ephrinB reverse signaling is involved in retinal ganglion cell (RGC) apoptosis in experimental glaucoma. Here, we further investigated the mechanisms underlying EphB/ephrinB reverse signaling activation induced RGC apoptosis in a rat chronic ocular hypertension (COH) model, using patch-clamp techniques in retinal slices. In COH retinas, RGCs showed higher spontaneous firing frequency and much more depolarized membrane potential as compared to control, which was mimicked by intravitreally injection of EphB2-Fc, an activator of ephrinB2...
March 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29298687/segmentation-error-in-spectral-domain-optical-coherence-tomography-measures-of-the-retinal-nerve-fibre-layer-thickness-in-idiopathic-intracranial-hypertension
#8
Anuriti Aojula, Susan P Mollan, John Horsburgh, Andreas Yiangou, Kiera A Markey, James L Mitchell, William J Scotton, Pearse A Keane, Alexandra J Sinclair
BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29285122/pathophysiological-correlations-between-fundus-fluorescein-angiography-and-optical-coherence-tomography-results-in-patients-with-idiopathic-epiretinal-membranes
#9
Ju Liu, Yong Qian, Shunnan Yang, Li Yan, Yi Wang, Meng Gao, Limei Liu, Yuanyuan Xiao, Bin Mo, Wu Liu
The aim of the current study was to determine the association between fundus fluorescein angiography (FFA) image results, optical coherence tomography (OCT) imaging results and visual functions in patients with idiopathic epiretinal membranes (ERMs). A total of 80 eyes from 40 patients diagnosed with ERM were analyzed. Best-corrected visual acuity (BCVA) and metamorphopsia were measured using the Early Treatment Diabetic Retinopathy Study eye chart and M-charts, respectively. Macular thickness and volume were determined using OCT...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29174113/ghrelin-protects-retinal-ganglion-cells-against-rotenone-via-inhibiting-apoptosis-restoring-mitochondrial-function-and-activating-akt-mtor-signaling
#10
Shenwen Liu, Sheng Chen, Jing Ren, Baijun Li, Bo Qin
Ghrelin, a 28-amino acid peptide hormone, has protective effects on neuronal cells. The present study aimed to examine the neuroprotective effects of ghrelin on the rat retinal ganglion cells in the rotenone-induced in vitro model of Parkinson's disease (PD). Cell viability and cell apoptosis were determined by MTT assay and flow cytometry, respectively. Mitochondrial functions were detected by mitochondrial complex I activity assay and mitochondrial membrane potential (MMP) assay. The mRNA and protein expression levels were determined by qRT-PCR and western blot, respectively...
February 2018: Neuropeptides
https://www.readbyqxmd.com/read/29132470/-effects-of-bone-marrow-mesenchymal-stem-cell-transplantation-on-retinal-neovascularization-in-neonatal-rats-with-oxygen-induced-retinopathy
#11
Qing-Jie Mu, Yue-Hua Zhao, Dan-Dan Cheng, Hai-Yu Wang, Lan-Fen Chen, Yan-Song Zhao, Xiao-Li Wang
OBJECTIVE: To explore the effects of rat bone mesenchymal stem cell (BMSC) transplantation on retinal neovascularization, and to observe the changes of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factors (VEGF) in rats with oxygen-induced retinopathy (OIR). METHODS: Seventy-two seven-day-old Sprague-Dawley rats were randomly divided into three groups: normal control (CON), model (OIR) and BMSC transplantation. In the BMSC transplantation group, BMSCs were transplanted 5 days after oxygen conditioning...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29039926/zebrafish-a-visual-model-to-evaluate-the-biofate-of-transferrin-receptor-targeted-7peptide-decorated-coumarin-6-micelles
#12
Ye Li, Xiaoning Song, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Xueqing Wang, Ying Zheng
In the present study, the zebrafish was explored as an in vivo model to assess the biofate of transferrin receptor (TfR)-targeted coumarin 6 (C6) micelles across various biological barriers. Three 7peptide (7pep)-decorated poly(ethylene glycol)-block-poly(ε-caprolactone) micelles loaded with fluorescence coumarin 6 (7pep-M-C6) with different ligand densities were constructed with particle sizes between 30 and 40 nm. Whole-mount immunostaining revealed that the expression level of TfR in the retina, brain, and intestine increased along with development stage...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29038978/panuveitis-like-reaction-following-encircling-laser-retinopexy-cerclage-in-a-21-year-old-male
#13
David Francis Fullon Chan, Milagros Herrera-Arroyo, Darby E Santiago, Teresita R Castillo, Ma Florentina Q Fajardo-Gomez
BACKGROUND: Severe vision-impairing ocular inflammation is rarely reported following extensive laser. Previous cases have involved retinal photocoagulation for diabetic retinopathy resolving over days. This report documents a rare instance of this where encircling retinopexy/cerclage was done as fellow eye retinal detachment prophylaxis in a patient with no overt comorbidities. RESULTS: A panuveitis-like reaction with severe, near-total visual impairment was documented 1 day following single-sitting encircling laser retinopexy/cerclage done as fellow eye prophylaxis for a 21-year-old male presenting with total retinal detachment in the other eye...
October 16, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29023785/cns-synapses-are-stabilized-trans-synaptically-by-laminins-and-laminin-interacting-proteins
#14
Dale D Hunter, Mary K Manglapus, Galina Bachay, Thomas Claudepierre, Michael W Dolan, Kelly-Ann Gesuelli, William J Brunken
The retina expresses several laminins in the outer plexiform layer (OPL), where they may provide an extracellular scaffold for synapse stabilization. Mice with a targeted deletion of the laminin β2 gene (Lamb2) exhibit retinal disruptions: photoreceptor synapses in the OPL are disorganized and the retinal physiological response is attenuated. We hypothesize that laminins are required for proper trans-synaptic alignment. To test this, we compared the distribution, expression, association and modification of several pre- and post-synaptic elements in wild-type and Lamb2-null retinae...
October 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28975619/impaired-ampa-receptor-trafficking-by-a-double-knockout-of-zebrafish-olfactomedin1a-b
#15
Naoki Nakaya, Afia Sultana, Stanislav I Tomarev
The olfm1a and olfm1b genes in zebrafish encode conserved secreted glycoproteins. These genes are preferentially expressed in the brain and retina starting from 16 h post-fertilization until adulthood. Functions of the Olfm1 gene is still unclear. Here, we produced and analyzed a null zebrafish mutant of both olfm1a and olfm1b genes (olfm1 null). olfm1 null fish were born at a normal Mendelian ratio and showed normal body shape and fertility as well as no visible defects from larval stages to adult. Olfm1 proteins were preferentially localized in the synaptosomes of the adult brain...
December 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28913997/additive-effect-of-oral-steroid-with-topical-nonsteroidal-anti-inflammatory-drug-for-preventing-cystoid-macular-edema-after-cataract-surgery-in-patients-with-epiretinal-membrane
#16
COMPARATIVE STUDY
Seonghwan Kim, Mee Kum Kim, Won Ryang Wee
PURPOSE: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. METHODS: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36)...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28892569/serine-racemase-deficiency-attenuates-choroidal-neovascularization-and-reduces-nitric-oxide-and-vegf-levels-by-retinal-pigment-epithelial-cells
#17
Haiyan Jiang, Mengjuan Wu, Yimei Liu, Liping Song, Shifeng Li, Xianwei Wang, Yun-Feng Zhang, Junxu Fang, Shengzhou Wu
Choroidal neovascularization (CNV) is a leading cause of blindness in age-related macular degeneration. Production of vascular endothelial growth factor (VEGF) and macrophage recruitment by retinal pigment epithelial cells (RPE) significantly contributes to the process of CNV in an experimental CNV model. Serine racemase (SR) is expressed in retinal neurons and glial cells, and its product, d-serine, is an endogenous co-agonist of N-methyl-d-aspartate receptor. Activation of the receptor results in production of nitric oxide ((...
November 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28888911/photobiomodulation-with-670-nm-light-ameliorates-m%C3%A3-ller-cell-mediated-activation-of-microglia-and-macrophages-in-retinal-degeneration
#18
Yen-Zhen Lu, Riccardo Natoli, Michele Madigan, Nilisha Fernando, Kartik Saxena, Riemke Aggio-Bruce, Haihan Jiao, Jan Provis, Krisztina Valter
Müller cells, the supporting cells of the retina, play a key role in responding to retinal stress by releasing chemokines, including CCL2, to recruit microglia and macrophages (MG/MΦ) into the damaged retina. Photobiomodulation (PBM) with 670 nm light has been shown to reduce inflammation in models of retinal degeneration. In this study, we aimed to investigate whether 670 nm light had an effect on Müller cell-initiated inflammation under retinal photo-oxidative damage (PD) in vivo and in vitro. Sprague-Dawley rats were pre-treated with 670 nm light (9J/cm2 ) once daily over 5 days prior to PD...
December 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28820183/technique-of-retinal-gene-therapy-delivery-of-viral-vector-into-the-subretinal-space
#19
K Xue, M Groppe, A P Salvetti, R E MacLaren
PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene therapy technique involved pre-operative planning with optical coherence tomography (OCT) and autofluorescence (AF) imaging, 23 G pars plana vitrectomy, internal limiting membrane staining with Membrane Blue Dual (DORC BV, Zuidland, Netherlands), a two-step subretinal injection using a 41 G Teflon tipped cannula (DORC) first with normal saline to create a parafoveal bleb followed by slow infusion of viral vector via the same self-sealing retinotomy...
September 2017: Eye
https://www.readbyqxmd.com/read/28767664/bruch%C3%A2-s-membrane-thickness-in-relationship-to-axial-length
#20
Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Bin Li, Jost B Jonas
PURPOSE: To assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length. METHODS: Human globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histological slides were histomorphometrically examined applying a digitized image analysis system...
2017: PloS One
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