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Pre retinal membrane

Souska Zandi, Florian Weisskopf, Justus G Garweg, Isabel B Pfister, Christian Pruente, Florian Sutter, Katja Hatz
BACKGROUND AND OBJECTIVES: The aim of this study was to identify the rate of early visual acuity poor responders in patients with neovascular age-related macular degeneration (AMD) after the first intravitreal injection of ranibizumab (Lucentis; Genentech, South San Francisco, CA) and to determine potential predictors for early response. PATIENTS AND METHODS: Patients with choroidal neovascularization secondary to AMD were evaluated before and 1 month after their first ranibizumab treatment...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
Sean McCafferty, April Harris, Corin Kew, Tala Kassm, Lisa Lane, Jason Levine, Meisha Raven
BACKGROUND: Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsification for the prevention of pseudophakic cystoid macular edema (PCME) using a prospective, randomized, double-masked, placebo-controlled clinical study. METHODS: Eyes (1000) were randomized to placebo (497) or nepafenac 0.3% (503) used once daily, post-operatively for 5 weeks at two ophthalmology clinics. Diagnosis of PCME was made by clinical, ocular coherence tomography (OCT), and with fluorescein angiography confirmation...
February 20, 2017: BMC Ophthalmology
M Fernanda Estrago-Franco, M Tarek Moustafa, Mohammad Riazi-Esfahani, Ashish U Sapkal, Rhina Piche-Lopez, A Jayaprakash Patil, Ashish Sharma, Payam Falatoonzadeh, Marilyn Chwa, Georgia Luczy-Bachman, Baruch D Kuppermann, M Cristina Kenney
PURPOSE: To identify inhibitors that could effectively lower reactive oxygen/nitrogen species (ROS/RNS), complement and inflammatory cytokine levels induced by Benzo(e)pyrene [B(e)p], an element of cigarette smoke, in human retinal pigment epithelial cells (ARPE-19) in vitro. METHODS: ARPE-19 cells were treated for 24 hours with 200 μM, 100 μM, and 50 μM B(e)p or DMSO (dimethyl sulfoxide)-equivalent concentrations. Some cultures were pre-treated with ROS/RNS inhibitors (NG nitro-L-arginine, inhibits nitric oxide synthase; Apocynin, inhibits NADPH oxidase; Rotenone, inhibits mitochondrial complex I; Antimycin A, inhibits mitochondria complex III) and ROS/RNS levels were measured with a fluorescent H2 DCFDA assay...
October 2016: Journal of Ophthalmic & Vision Research
Arturo Ortin-Martinez, En Leh Samuel Tsai, Philip E Nickerson, Miriam Bergeret, Yao Lu, Sheila Smiley, Lacrimioara Comanita, Valerie A Wallace
The utilization of fluorescent reporter transgenes to discriminate donor versus host cells has been a mainstay of photoreceptor transplantation research, the assumption being that the presence of reporter+ cells in outer nuclear layer (ONL) of transplant recipients represents the integration of donor photoreceptors. We previously reported that GFP(+) cells in the ONL of cone-GFP transplanted retinas exhibited rod-like characteristics, raising the possibility that GFP signal in recipient tissue may not be a consequence of donor cell integration...
December 14, 2016: Stem Cells
Ravinder Jerath, Shannon M Cearley, Vernon A Barnes, Elizabeth Nixon-Shapiro
The role of the physiological processes involved in human vision escapes clarification in current literature. Many unanswered questions about vision include: 1) whether there is more to lateral inhibition than previously proposed, 2) the role of the discs in rods and cones, 3) how inverted images on the retina are converted to erect images for visual perception, 4) what portion of the image formed on the retina is actually processed in the brain, 5) the reason we have an after-image with antagonistic colors, and 6) how we remember space...
November 2016: Medical Hypotheses
H Sasaki, A Shiono, J Kogo, R Yomoda, Y Munemasa, M Syoda, H Otake, H Kurihara, Y Kitaoka, H Takagi
PurposeTo determine whether the inverted internal limiting membrane (ILM) flap technique contributes to high reattachment and closure rates in patients with macular hole-associated retinal detachment (MHRD).Patients and methodsIn all, 15 eyes of 15 patients with MHRD undergoing 25-gauge pars plana vitrectomy with the inverted ILM flap technique or ILM peeling. The patients were divided into the inverted ILM flap technique group (6 eyes) and ILM peeling group (9 eyes). The logarithm of minimal angle of resolution best-corrected visual acuity (BCVA) and retinal attachment and macular hole closure rates were compared between the two groups before and after surgery...
April 2017: Eye
Paula E Tenconi, Norma M Giusto, Gabriela A Salvador, Melina V Mateos
Inflammation is a key factor in the pathogenesis of several retinal diseases. In view of the essential role of the retinal pigment epithelium in visual function, elucidating the molecular mechanisms elicited by inflammation in this tissue could provide new insights for the treatment of retinal diseases. The aim of the present work was to study protein kinase C signaling and its modulation by phospholipases D in ARPE-19 cells exposed to lipopolysaccharide. This bacterial endotoxin induced protein kinase C-α/βII phosphorylation and protein kinase-ε translocation to the plasma membrane in ARPE-19 cells...
December 2016: International Journal of Biochemistry & Cell Biology
David H W Steel, Christiana Dinah, Kathryn White, Peter J Avery
PURPOSE: A dissociated optic nerve fibre layer (DONFL) is a characteristic change noted in inner retinal morphology after internal limiting membrane (ILM) peeling. It is thought to be due to trauma to Muller cells as the ILM is peeled from their attached end plates. In this study, we aimed to determine the extent and size of Muller cell debris on the retinal side of excised ILM and assess whether this correlated with the extent of DONFL observed postoperatively. METHOD: Prospective single centre study of a consecutive series of patients undergoing macular hole surgery...
March 2017: Acta Ophthalmologica
Jost B Jonas, Kyoko Ohno-Matsui, Leonard Holbach, Songhomitra Panda-Jonas
PURPOSE: To assess associations between axial length and density of retinal pigment epithelium (RPE) cells in various ocular regions. METHODS: The histomorphometric investigation included histological sections of enucleated eyes of Caucasian patients. Using a light microscope, we counted the number of RPE cells on Bruch's membrane at the ora serrata, in the pre-equatorial region, the equatorial and retro-equatorial region, at the midpoint equator/posterior pole, and at the posterior pole...
February 2017: Acta Ophthalmologica
Yao Lu, Liang Han, Changguan Wang, Hongliang Dou, Xuefeng Feng, Yuntao Hu, Kang Feng, Xin Wang, Zhizhong Ma
PURPOSE: To compare the outcome after choroidal neovascular (CNV) membrane excision and retinal pigment epithelium (RPE) transplantation and make further evaluation of two types of RPE grafts on the visual function in patients with neovascular age-related macular degeneration (AMD), complicated by massive subretinal haemorrhage. METHODS: We retrospectively reviewed 80 patients who underwent CNV membrane excision with or without RPE transplantation. Two types of RPE grafts were adopted, RPE-Bruch's membrane complex graft (subgroup 1) and RPE monolayer sheet graft (subgroup 2)...
August 6, 2016: Acta Ophthalmologica
Yoshikazu Ichikawa, Yutaka Imamura, Masahiro Ishida
PURPOSE: To determine whether the degree of metamorphopsia significantly correlated with the distance of the tangenital retinal displacement after epiretinal membrane surgery. METHODS: The M-CHARTS were used to measure the vertical metamorphopsia score and the horizontal score. The distances between the intersections of two sets of retinal vessels situated vertically or horizontally were measured in the near-infrared Spectralis images. RESULTS: Fifty eyes of 50 patients (22 men; age, 69...
April 2017: Retina
Yuya Terubayashi, Teruyo Kida, Masanori Fukumoto, Jun Sugasawa, Seita Morishita, Hiroyuki Suzuki, Tsunehiko Ikeda
PURPOSE: Retinal arterial macroaneurysm (RAM) has been reported in association with branch retinal vein occlusion (BRVO), and usually BRVO precedes RAM. We present a long-term follow-up case report of unilateral multiple RAMs that developed BRVO following ruptured RAM in the same retinal quadrant. CASE PRESENTATION: An 80-year-old woman presented with floaters in her right eye in June 2012. Visual acuity (VA) was 20/25 in her right eye with posterior capsular opacity...
January 2016: Case Reports in Ophthalmology
Stratos Gotzaridis, Efstathios Liazos, Petros Petrou, Ilias Georgalas
PURPOSE: A retrospective consecutive case series to evaluate the safety and efficacy of 25 gauge pars plana vitrectomy, ILM peeling, 20% SF6 gas tamponade and strict posturing for the treatment of idiopathic full-thickness macular holes. METHODS: We report the results of 106 consecutive eyes that underwent standard 25-gauge pars plana vitrectomy, brilliant peel-assisted internal limiting membrane peel, fluid:gas exchange with 20% SF6 and strict posturing for one week...
July 1, 2016: Seminars in Ophthalmology
J G Garweg
BACKGROUND: Current understanding of the mechanisms that underlie the long-term consequences of anti-VEGF therapy in wet, age-related macular degeneration (AMD) is poor. Here, the impact of this treatment on the development of macular atrophy (MA) is discussed based on our current pathophysiological understanding. METHODS: This review is based on a PubMed literature survey using the MeSH terms "wet AMD" and "macular atrophy" (151 hits) and limited to publications since 2013 (n = 90)...
December 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Michael J Koss, Paulo Falabella, Francisco R Stefanini, Marcel Pfister, Biju B Thomas, Amir H Kashani, Rodrigo Brant, Danhong Zhu, Dennis O Clegg, David R Hinton, Mark S Humayun
PURPOSE: A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular degeneration (AMD) and severe vision loss. CPCB-RPE1 is composed of a terminally differentiated, polarized human embryonic stem cell-derived RPE (hESC-RPE) monolayer pre-grown on a biocompatible, mesh-supported submicron parylene C membrane. The objective of the present delivery study was to assess the feasibility and 1-month safety of CPCB-RPE1 implantation in Yucatán minipigs, whose eyes are similar to human eyes in size and gross retinal anatomy...
August 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Hulya Gungel, Cigdem Altan, Deniz Oygar Baylancicek, Yesim Karagoz, Tanju Kisbet
PURPOSE: To evaluate using Doppler ultrasonography (DUS) how pars plana vitrectomy (PPV) affects orbital circulation in diffuse diabetic macular edema (DME) associated with either the epiretinal membrane (ERM) or taut posterior hyaloid (TPH). METHODS: The sample included 46 eyes of 42 patients with DME associated with the ERM (n = 22, Group 1) or TPH (n = 24, Group 2). All participants received panretinal laser photocoagulation and antivascular endothelial growth factor injections preoperatively and underwent 23-gauge PPV combined with ERM or TPH removal and internal limiting membrane (ILM) peeling...
January 2017: Current Eye Research
Deepak Khadka, Sanjeeb Bhandari, Sanyam Bajimaya, Raba Thapa, Govinda Paudyal, Eli Pradhan
BACKGROUND: Premacular subhyaloid hemorrhage results in a sudden profound loss of vision. Among the modalities for its treatment, Nd:YAG laser hyaloidotomy is a non invasive method enabling rapid drainage of the obstructed macular area and improved vision within days. This study was aimed to evaluate the efficacy, visual outcome and complications following Nd:YAG laser hyaloidotomy for premacular subhyaloid hemorrhage. METHODS: Patients with premacular subhyaloid hemorrhage of more than 3 disc diameters (DD) of various etiologies, attending Tilganga Institute of Ophthalmology, Nepal from August, 2014 to February, 2015, were included...
April 18, 2016: BMC Ophthalmology
V P Papastefanou, M Pefkianaki, L Al Harby, A K Arora, V M L Cohen, R M Andrews, M S Sagoo
PurposeThe purpose of this study is to present the outcomes of a series of patients with choroidal neovascular membrane (choroidal neovascularisation (CNV)) secondary to a choroidal osteoma undergoing anti-VEGF monotherapy.Patients and methodsRetrospective series of patients with choroidal neovascularization secondary to choroidal osteoma. All patients underwent clinical and imaging assessment (fundus photo, B-scan ultrasonography, fluorescein angiography, and optical coherence tomography-where available), and were managed with intravitreal anti-VEGF injections (Bevacizumab)...
June 2016: Eye
Danielescu Ciprian
Proliferative vitreoretinopathy (PVR) is the most important complication of rhegmatogenous retinal detachment (RRD) and the main cause of RRD surgery failure. This is a review of recent literature data, which concerns PVR pathogeny and risk factors. The occurrence of pre- and subretinal membranes is a consequence of retinal pigment epithelial cells activation and migration, with concomitant participation of inflammatory cells. The newly synthesized extracellular matrix interacts with cells promoting membrane contraction...
April 2015: Romanian Journal of Ophthalmology
Aashish Anand, Anastas Pass, Mian Z Urfy, Rosa Tang, Christian Cajavilca, Eusebia Calvillo, Jose I Suarez, Chethan P Venkatasubba Rao, Eric M Bershad
We aimed to determine if there are measurable objective changes in the optic nerve head (ONH) immediately after cerebrospinal fluid (CSF) drainage in a prospective case-series of five patients undergoing a clinically indicated lumbar puncture (LP) for diagnosis of idiopathic intracranial hypertension. A Cirrus high-definition optical coherence tomography machine (Carl Zeiss Meditec, Dublin, CA, USA) was used to acquire images in the lateral decubitus position. Optic disc cube and high-definition line raster scans centered on the ONH were obtained immediately before and after draining CSF, while the patient maintained the lateral decubitus position...
July 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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