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https://www.readbyqxmd.com/read/29775074/recent-changes-of-classification-for-squamous-intraepithelial-lesions-of-the-head-and-neck
#1
Kyung-Ja Cho, Joon Seon Song
CONTEXT: - Interpretation of atypical squamous lesions of the head and neck has always been a nettlesome task for pathologists. Moreover, many different grading systems for squamous intraepithelial lesions have been proposed in past decades. The recent World Health Organization 2017 classification presents 2 types of 2-tier systems for laryngeal and oral precursor lesions. OBJECTIVE: - To review the recent changes in classification and the clinical significance for squamous intraepithelial lesions of the head and neck...
May 18, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29773664/cognitive-development-and-quality-of-life-associated-with-bpd-in-10-year-olds-born-preterm
#2
Sudhir Sriram, Michael D Schreiber, Michael E Msall, Karl C K Kuban, Robert M Joseph, T Michael O' Shea, Elizabeth N Allred, Alan Leviton
OBJECTIVES: To compare neurocognitive, language, executive function, academic achievement, neurologic and behavioral outcomes, and quality of life at age 10 years in children born extremely preterm who developed bronchopulmonary dysplasia (BPD) to children who did not develop BPD. METHODS: The Extremely Low Gestational Age Newborns study population included 863 children born extremely preterm whose BPD status before discharge was known had an IQ (Differential Ability Scales II [DAS II]) assessment at 10 years...
May 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29769506/evaluating-the-role-of-immunological-cells-tissue-eosinophils-and-mast-cells-in-progression-of-oral-squamous-cell-carcinoma
#3
S Saxena, A Singh, P Singh, K S Sundaragiri, B Sankhla, A Bhargava
Mast cells and eosinophils are increased in oral squamous cell carcinoma. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of the study was to study the mast cells and eosinophils between normal oral mucosa, leukoplakia and oral squamous cell carcinoma and to study the significance of mast cells in the progression of the lesion. A retrospective study was done on archival tissue received from January 2015 to December 2015, in the Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29763881/orally-administered-brown-seaweed-derived-%C3%AE-glucan-effectively-restrained-development-of-gastric-dysplasia-in-a4gnt-ko-mice-that-spontaneously-develop-gastric-adenocarcinoma
#4
Mark Joseph Desamero, Shigeru Kakuta, James Kenn Chambers, Kazuyuki Uchida, Satoshi Hachimura, Masaya Takamoto, Jun Nakayama, Hiroyuki Nakayama, Shigeru Kyuwa
β-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing β-(1,3)-d-linked glucose polymers with branches connected by either β-(1,4) or β-(1,6) glycosidic linkage. To date, an extensive amount of scientific evidence supports their multifunctional biological activities, but their potential involvement in the progression of premalignant lesions remains to be clarified. A4gnt KO mice that lack α1,4-N-acetylglucosamine-capped O-glycans in gastric gland mucin are a unique animal model for gastric cancer because the mutant mice spontaneously develop gastric cancer through hyperplasia-dysplasia-adenocarcinoma sequence...
May 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29752448/regulation-of-proliferation-and-cell-cycle-by-protein-regulator-of-cytokinesis-1-in-oral-squamous-cell-carcinoma
#5
Fanglong Wu, Xueke Shi, Rui Zhang, Yuan Tian, Xiangjian Wang, Changlei Wei, Duo Li, Xiaoyu Li, Xiangli Kong, Yurong Liu, Weihua Guo, Yiqing Guo, Hongmei Zhou
Protein regulator of cytokinesis 1 (PRC1), a microtubule-associated protein, has emerged as a critical regulator of proliferation and apoptosis, acting predominantly in numerous tumors. However, its function in oral squamous cell carcinoma (OSCC) is still unknown. To establish the roles of PRC1 in OSCC, 95 oral clinical samples (54 OSCC, 24 oral leukoplakia [OLK], and 17 normal oral mucosa) and seven oral cell lines (6 OSCC and 1 normal oral cell lines) were analyzed using a series of molecular and genomic assays both in vivo and in vitro were conducted in this study...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29751770/systemically-administered-allogeneic-mesenchymal-stem-cells-do-not-aggravate-the-progression-of-precancerous-lesions-a-new-biosafety-insight
#6
Flavia Bruna, Anita Plaza, Martha Arango, Iris Espinoza, Paulette Conget
BACKGROUND: Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate whether systemically administered allogeneic MSCs modify the natural progression of precancerous lesions and whether their putative effect depends on cancer stage and/or cell dose...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29751747/a-fatal-case-associated-with-respiratory-syncytial-virus-infection-in-a-young-child
#7
Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian, Zhengde Xie
BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old...
May 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29750890/impact-of-age-on-disease-progression-and-microenvironment-in-oral-cancer
#8
V K Vincent-Chong, H DeJong, L J Rich, A Patti, M Merzianu, P A Hershberger, M Seshadri
Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squamous cell carcinoma (HNSCC). Experimental studies were conducted with the 4-nitroquinoline-oxide (4NQO) oral carcinogenesis model and orthotopic FaDu HNSCC xenografts, established in young (7 to 12 wk of age) and old (65 to 70 wk of age) female C57BL/6 mice ( n = 44; 4NQO model) and severe combined immunodeficient mice ( n = 13; HNSCC xenografts)...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29746151/determinants-of-successful-direct-breastfeeding-at-hospital-discharge-in-high-risk-premature-infants
#9
Lara Casey, Sandra Fucile, Kimberly E Dow
BACKGROUND: Despite a mother's intention to breastfeed, there are many barriers to feeding preterm infants that decrease breastfeeding rates. OBJECTIVE: The objective of this research was to determine factors associated with successful direct breastfeeding (DBF) of the preterm infant at hospital discharge. MATERIALS AND METHODS: A retrospective chart review of 69 preterm (<34 weeks' gestational age) infants in the neonatal intensive care unit, whose mothers intended to breastfeed, was conducted...
May 10, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29731815/oral-lichen-planus-and-malignant-transformation-the-role-of-p16-ki-67-bub-3-and-sox4-in-assessing-precancerous-potential
#10
Eduardo Augusto Rosa, Aura Maria Hurtado-Puerto, Denise Pinheiro Falcão, Aline Patricia Brietzke, Luiz Eduardo De Almeida Prado Franceschi, Florlorêncio Figueiredo Cavalcanti Neto, Valdenize Tiziane, Fabiana Pirani Carneiro, Evelyn Mikaela Kogawa, Heitor Moreno, Rivadávio Fernandes Batista Amorim
The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controversial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub-3) and sex-determining region Y-related high mobility group box 4 (SOX4), and their roles as precancerous biomarkers in OLP. A retrospective study was performed, in which tissue blocks of OLP, oral dysplasia (OD), cutaneous lichen planus (CLP) and oral fibrous hyperplasia (OFH) were used (n=120)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29731561/postoperative-pathologic-assessment-of-surgical-margins-in-oral-cancer-a-contemporary-review
#11
REVIEW
Arpan K Shah
Adequacy of resection margins is of utmost importance for decisions regarding postoperative treatment and prediction of prognosis in patients with oral squamous cell carcinoma. However, there are differences in opinions about various basic concepts of surgical margins in oral and maxillofacial pathology. Fundamental issues such as concepts of positive or negative surgical margins and impact of epithelial dysplasia at margin require clarification to standardize the practice of postoperative margin surveillance...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29731558/evaluating-the-expression-of-p16-and-p27-in-oral-epithelial-dysplasias-and-oral-squamous-cell-carcinoma-a-diagnostic-marker-for-carcinogenesis
#12
Lalita Jayaram Thambiah, R V Bindushree, Afshan Anjum, Satish Kumaran Pugazhendi, Lokesh Babu, Renju Prem Nair
Objective: Immunohistochemical evaluation of the degree of expression of p16 and p27 in oral epithelial dysplasia and different histological grades oral squamous carcinoma. Materials and Methods: The study consisted of 5 cases of oral squamous cell carcinoma (OSCC), 5 cases of low-risk potentially malignant disorders (PMDs), 5 cases of high-risk PMDs and 5 cases of normal epithelium. Five micrometer thickness sections on a positively charged slide were subjected to immunohistochemical staining for the localization of p16 and p27...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29731555/coalition-of-e-cadherin-and-vascular-endothelial-growth-factor-expression-in-predicting-malignant-transformation-in-common-oral-potentially-malignant-disorders
#13
P Sharada, Uma Swaminathan, B R Nagamalini, K Vinod Kumar, B K Ashwini, Vln Lavanya
Background: Reduced E-cadherin expression and increased VEGF expression is known to be involved in tissue growth and transformation of Oral Potentially Malignant Disorders (OPMDs) and has been correlated with their differing histological grades in numerous studies. Aim: To evaluate Immunohistochemical (IHC) expression of both E-cadherin and VEGF in predicting the malignant transformation potential of common OPMDs. Materials and Methods: Ten cases each of Normal Oral mucosa (NOM), Mild Oral Epithelial Dysplasia (OED), Moderate OED, Severe OED, Oral Submucous Fibrosis, (OSMF) and Oral Squamous Cell Carcinoma (OSCC) were stained and evaluated for the expression of Ecadherin and VEGF...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29725529/non-invasive-imaging-of-actinic-cheilitis-and-squamous-cell-carcinoma-of-the-lip
#14
Mihai Lupu, Ana Caruntu, Constantin Caruntu, Daniel Boda, Liliana Moraru, Vlad Voiculescu, Alexandra Bastian
An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29714078/overexpression-of-p21-activated-kinase-2-is-correlated-with-high-grade-oral-squamous-cell-carcinomas
#15
Yao Xiao, Wei-Wei Deng, Lei-Lei Yang, Hao Li, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
AIM: p21-activated kinase 2 (PAK2) is overexpressed in several tumors but the expression of PAK2 in oral squamous cell carcinomas (OSCCs) remains unclear. MATERIALS & METHODS: Immunohistochemistry was performed on human tissue microarrays containing 165 primary OSCC, 48 oral epithelial dysplasia and 43 normal oral mucosa. RESULTS: PAK2 expression was increased in primary OSCC compared with normal mucosa and significantly increased in primary OSCC grade III compared with grade I, but independent of overall survival rate...
May 1, 2018: Future Oncology
https://www.readbyqxmd.com/read/29709496/molecular-markers-associated-with-development-and-progression-of-potentially-premalignant-oral-epithelial-lesions-current-knowledge-and-future-implications
#16
REVIEW
Nikolaos G Nikitakis, Monica Pentenero, Maria Georgaki, Catherine F Poh, Douglas E Peterson, Paul Edwards, Mark Lingen, John J Sauk
Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge...
April 4, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29705090/alterations-in-the-expression-of-dna-damage-response-related-molecules-in-potentially-preneoplastic-oral-epithelial-lesions
#17
Nikolaos G Nikitakis, George Z Rassidakis, Jason Tasoulas, Ioannis Gkouveris, Georgios Kamperos, Argyrios Daskalopoulos, Alexandra Sklavounou
OBJECTIVES: The aim of this study was to evaluate the expression levels of DNA damage response (DDR) markers in potentially preneoplastic oral epithelial lesions (PPOELs). STUDY DESIGN: Immunohistochemical expression of DDR markers (γΗ2 ΑΧ, pChk2, 53 BP1, p53, and phosphorylated at Ser 15 p53) was assessed in 41 oral leukoplakias, ranging from hyperplasia (H) to dysplasia (D) and in comparison with oral squamous cell carcinoma (OSCC) and normal mucosa (NM). Statistical and receiver operating characteristic curve analysis were performed...
March 22, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29695206/efficacy-and-safety-of-oral-paracetamol-versus-oral-ibuprofen-for-closure-of-patent-ductus-arteriosus-in-preterm-infants-a-randomized-controlled-trial
#18
Rania A El-Farrash, Mohammed S El Shimy, Abeer S El-Sakka, Manal G Ahmed, Dina G Abdel-Moez
OBJECTIVE: To evaluate the efficacy and safety of oral paracetamol versus oral ibuprofen in the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. STUDY DESIGN: An interventional randomized case-control study, registered in ClinicalTrials.gov ( NCT03265782 ), was conducted on 60 preterm infants with gestational age ≤ 34 weeks, postnatal age of 2-7 days and color Doppler echocardiographic evidence of hsPDA. Neonates were randomly assigned to two groups; 30 received oral ibuprofen and 30 received oral paracetamol...
April 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29687243/endorsing-cellular-competitiveness-in-aberrant-epithelium-of-oral-submucous-fibrosis-progression-neighbourhood-analysis-of-immunohistochemical-attributes
#19
Anji Anura, Anees Kazi, Mousumi Pal, Ranjan Rashmi Paul, Sanghamitra Sengupta, Jyotirmoy Chatterjee
Epithelial abnormality during the transformation of oral submucous fibrosis (OSF) into oral squamous cell carcinoma has been well studied and documented. However, the differential contribution of atrophy and hyperplasia for malignant potentiality of OSF is yet to be resolved. Existing diagnostic conjectures lack precise diagnostic attributes which may be effectively resolved by substantiation of specific molecular pathology signatures. Present study elucidates existence of cellular competitiveness in OSF conditions using computer-assisted neighbourhood analysis in quantitative immunohistochemistry (IHC) framework...
April 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29686705/intraoral-potentially-malignant-disorders-in-a-brazilian-oral-pathology-service-epidemiological-clinical-and-histopathological-findings
#20
Fernanda Weber Mello, Gilberto Melo, Maria Inês Meurer, Elena Riet Correa Rivero
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Histological diagnoses were collected from histopathological records. Among 208 IOPMD cases, 84.13% involved LKP; 11.1%, ELKP; and 4...
2018: Journal of Oncology
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