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https://www.readbyqxmd.com/read/27900245/image-analysis-assisted-study-of-mitotic-figures-in-oral-epithelial-dysplasia-and-squamous-cell-carcinoma-using-differential-stains
#1
Ankita Tandon, Narendra Nath Singh, V R Brave, Gadiputi Sreedhar
BACKGROUND: Mitosis is a process of cell division resulting in two genetically equivalent daughter cells. Excessive proliferation of cells due to mitosis is the hallmark in pre cancer and cancer. AIMS: This study was conducted to count the number of mitotic figures in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma in both Hematoxylin and Eosin (H&E) and Crystal Violet stained sections. Also the overall number of mitotic figures with both stains were compared along with the evaluation of staining efficacy of both the stains...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899983/hur-and-podoplanin-expression-is-associated-with-a-high-risk-of-malignant-transformation-in-patients-with-oral-preneoplastic-lesions
#2
Umma Habiba, Tetsuya Kitamura, Aya Yanagawa-Matsuda, Fumihiro Higashino, Kyoko Hida, Yasunori Totsuka, Masanobu Shindoh
The risk of malignant transformation in oral preneoplastic lesions (OPLs) is challenging to assess. The objective of the present study was to determine the expression of ELAV like RNA binding protein 1 (HuR) and podoplanin in OPLs, and to evaluate the use of each protein as biomarkers for the risk assessment of malignant transformations. Immunohistochemistry for HuR and podoplanin was performed on the tissues of 51 patients with OPL, including cases of low grade dysplasia (LGD) and high grade dysplasia (HGD)...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27890699/ayurvedic-management-of-spondyloepiphyseal-dysplasia-tarda-a-rare-hereditary-disorder
#3
Sarvesh Kumar Singh, Kshipra Rajoria
Spondyloepiphyseal dysplasia tarda (SEDT) is a rare genetic disease in which patient suffers from short stature, short trunk and neck with disproportionately long arms, coxa vara, skeletal features such as barrel shaped chest, kyphosis, scoliosis and early arthropathy. Only limited medical and surgical management is available in modern medicine. A 15 years old male suffering from SEDT and diagnosed as Vata vyadhi was treated with Panchakarma therapy and selected Ayurvedic oral medicines. Ayurvedic treatment was directed to ameliorate the orthopaedic clinical conditions in this case...
November 25, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#4
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
November 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27865803/leukoplakia-a-diagnostic-and-management-algorithm
#5
REVIEW
Alessandro Villa, Sook Bin Woo
Oral white lesions are frequently encountered in daily practice. Most white lesions are benign (eg, reactive keratoses or keratoses from inflammatory conditions) and the diagnosis is usually evident from the clinical presentation and histopathology. Leukoplakia is a common condition characterized by an increased risk for malignant transformation. Histopathology of leukoplakia can disclose hyperkeratosis with dysplasia or carcinoma or hyperkeratosis or parakeratosis without dysplasia. Treatment depends on demographic, social, clinical, and histopathologic factors...
October 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27865370/hypermethylated-znf582-and-pax1-are-effective-biomarkers-for-detection-of-oral-dysplasia-and-oral-cancer
#6
Shih-Jung Cheng, Chi-Feng Chang, Jang-Jaer Lee, Hsin-Ming Chen, Huei-Jen Wang, Yu-Ligh Liou, Carolyn Yen, Chun-Pin Chiang
OBJECTIVES: This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS: Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral precancer patients, and 95 oral squamous cell carcinoma patients. Methylation levels of the five genes were quantified by real-time methylation-specific PCR after bisulfite conversion...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27863823/general-endotracheal-vs-non-endotracheal-regional-anesthesia-for-elective-inguinal-hernia-surgery-in-very-preterm-neonates-a-single-institution-experience
#7
Jean Gurria, Phillip Kuo, Angie Kao, Luisa Christensen, AiXuan Holterman
BACKGROUND: Very pre-term infants (VP) at <32 weeks post menstrual age PMA have a high incidence of bronchopulmonary dysplasia BPD. BPD places them at risk for pulmonary-related perioperative complications from general endotracheal anesthesia GE during elective inguinal hernia repair. METHODS: A retrospective cohort study was done to compare pulmonary-related perioperative risks between VP patients undergoing non-emergent inguinal hernia repair prior to NICU discharge under GE (n=58) vs regional anesthesia RA (n=37)...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27860386/raman-spectroscopy-can-discriminate-between-normal-dysplastic-and-cancerous-oral-mucosa-a-tissue-engineering-approach
#8
Salman A Mian, Ceyla Yorucu, Muhammad Saad Ullah, Ihtesham U Rehman, Helen E Colley
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma. However, less than 18% of suspicious oral lesions progress to cancer, with diagnosis currently relying on histopathological evaluation, which is invasive and time consuming. A non-invasive, real-time, point-of-care method could overcome these problems and facilitate regular screening...
November 10, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27849339/immunohistochemical-study-of-p21-and-bcl-2-in-leukoplakia-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#9
Rakesh V Sutariya, Bhari Sharanesha Manjunatha
BACKGROUND: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia). OBJECTIVES: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27847523/intra-articular-hyaluronic-acid-compared-to-traditional-conservative-treatment-in-dogs-with-osteoarthritis-associated-with-hip-dysplasia
#10
Gabriel O L Carapeba, Poliana Cavaleti, Gabriel M Nicácio, Rejane B Brinholi, Rogério Giuffrida, Renata N Cassu
The purpose of this study was to compare the efficacy of the intra-articular (IA) hyaluronic acid injection to traditional conservative treatment (TCT) in dogs with osteoarthritis (OA) induced by hip dysplasia. Sixteen dogs were distributed into two groups: Hyal: IA injection of hyaluronic acid (5-10 mg), and Control: IA injection with saline solution (0.5-1.0 mL) in combination with a TCT using an oral nutraceutical (750-1000 mg every 12 h for 90 days) and carprofen (2.2 mg/kg every 12 h for 15 days)...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27826624/mesenchymal-stem-cells-derived-from-normal-gingival-tissue-inhibit-the-proliferation-of-oral-cancer-cells-in-vitro-and-in-vivo
#11
Xiaoli Ji, Zhihui Zhang, Ying Han, Jiangyuan Song, Xiangliang Xu, Jianqiu Jin, Sha Su, Dongdong Mu, Xiaodan Liu, Si Xu, Hongwei Cui, Zhongfang Zhao, Yixiang Wang, Hongwei Liu
The interplay between tumor cells and mesenchymal stem cells (MSCs) within tumor microenvironment plays a significant role in tumor development, and thus might be exploited for therapeutic intervention. In this study, we isolated MSCs from normal gingival tissue (GMSCs), and detected the effect of GMSCs on oral cancer cells via direct co-culture and indirect co-culture systems. The cell proliferation assay of direct co-culture showed that GMSCs could inhibit the growth of oral cancer cells. Conditioned medium derived from GMSCs (GMSCs-CM) also exerted an anticancer effect, which indicates that soluble factors in GMSCs-CM played a dominant role in GMSCs-induced cancer cell growth inhibition...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27825664/-florid-osseous-dysplasia-management-of-a-symptomatic-case
#12
M Maccotta, L Radoï
INTRODUCTION: Florid osseous dysplasia is a rare and benign fibro-osseous pathology, in which bone is replaced by fibrous tissue and metaplastic bone. It can remain asymptomatic for a long time and is most often discovered incidentally during a radiological examination. Sometimes, patients are seen because of an infectious complication. OBSERVATION: An edentulous 62 years-old woman was referred for a painful mandibular swelling preventing insertion of her removable denture...
November 4, 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27790587/immunohistochemical-expression-of-cyclin-b1-in-epithelial-hyperplasia-dysplasia-and-oral-squamous-cell-carcinomas-a-comparative-study
#13
Kochli Channappa Niranjan, Amsavardani Tayaar, G S Kumar, Rekha Krishnapillai, Kaveri Hallikeri, Santosh Hunasgi
INTRODUCTION: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis. AIM: Over expression of Cyclin B1, has been reported more recently in breast, colon, prostate, oral and esophageal carcinomas. Thus, the aim of the present study was to examine the expression of Cyclin B1 in hyperplasia, dysplasia and Oral Squamous Cell Carcinomas (OSCC)...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27782368/issues-related-to-diagnosing-oral-lichen-planus-among-oral-pathologists-in-south-india-a-pilot-survey
#14
D Sharathkumar Sanketh, Samuel Raj Srinivasan, Shankargouda Patil, Kannan Ranganathan
AIM: In the present study, we simulated clinical scenarios by explicitly describing the history and clinical and histological features of hypothetical patients presenting with oral lichen planus (OLP), oral lichenoid lesion, and epithelial dysplasia in a self-designed questionnaire. By doing so, we aimed to elicit a diagnosis from oral pathologists and trainees, analyze their responses, appraise issues, and propose solutions regarding the diagnosis of OLP. METHODS: The questionnaire was distributed to 100 oral pathologists and trainees in South India...
October 26, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27773561/nbi-utility-in-the-pre-operative-and-intra-operative-assessment-of-oral-cavity-and-oropharyngeal-carcinoma
#15
Giancarlo Tirelli, Marco Piovesana, Annalisa Gatto, Lucio Torelli, Roberto Di Lenarda, Francesca Boscolo Nata
PURPOSE: Despite advances in the surgical management of head and neck squamous cell carcinoma, the identification of synchronous lesions, precancerous lesions around the main tumor, or the unknown primary in the case of neck metastasis remains a problem, as these lesions may be invisible to the naked eye or with standard white light (WL) endoscopy. However, the advent of tools such as narrow-band imaging (NBI) could help the clinician. The purpose of this study was to assess the impact of NBI during the pre-operative and intra-operative stages of management of oral and oropharyngeal cancers...
October 1, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27770472/whatsapp-is-an-effective-tool-for-obtaining-second-opinion-in-oral-pathology-practice
#16
Sachin C Sarode, Gargi S Sarode, Rahul Anand, Shankargouda Patil, Hemant Unadkat
BACKGROUND: The aim of this study was to find out the efficacy of WhatsApp application for obtaining second opinion on histopathological diagnosis in oral pathology practice. METHODS: A total of 247 cases comprising of 34 different oral pathologies were photomicrographed using smartphone cameras through compound microscopes and sent for second opinion diagnosis (SOD) to 20 different oral pathologists using WhatsApp. RESULTS: Of 4795 (97.06%) total second opinion received, correct SOD were received for 4710 (98...
October 22, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27767902/maternal-administration-of-meclozine-for-the-treatment-of-foramen-magnum-stenosis-in-transgenic-mice-with-achondroplasia
#17
Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
OBJECTIVE Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Foramen magnum stenosis (FMS) is one of the serious neurological complications in ACH. Through comprehensive drug screening, the authors identified that meclozine, an over-the-counter drug for motion sickness, inhibited activation of FGFR3 signaling. Oral administration of meclozine to the growing ACH mice promoted longitudinal bone growth, but it did not prevent FMS...
October 21, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27734976/human-papillomavirus-and-head-and-neck-carcinomas-focus-on-evidence-in-the-babel-of-published-data
#18
P Morbini, M Benazzo
Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined entity mostly affecting young to middle-aged male non-smokers. It is generally associated with a favourable outcome, and for this reason a less intensive therapeutic approach has been proposed for this subset of patients. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Italian population. Furthermore, among other head and neck regions, a smaller proportion of oral high-grade dysplasia and cancers seems to depend on HPV infection, whereas its role in laryngeal cancer is recognised as less relevant...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27729740/characterisation-of-colonic-dysplasia-like-epithelial-atypia-in-murine-colitis
#19
Sarron Randall-Demllo, Ruchira Fernando, Terry Brain, Sukhwinder Singh Sohal, Anthony L Cook, Nuri Guven, Dale Kunde, Kevin Spring, Rajaraman Eri
AIM: To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS: Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles. After the third cycle, mice were killed and colonic tissue collected for histological and immunohistochemical evaluation. Inflammation and severity of dysplasia in the colonic mucosa were assessed in H&E sections of the colon...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27723629/gstm1-null-polymorphism-prevalence-in-tobacco-users-oral-leukoplakia-and-oral-squamous-cell-carcinoma-patients-in-south-indian-population-a-polymerase-chain-reaction-study
#20
Renu Tanwar, Asha R Iyengar, K S Nagesh, Seema Patil, B V Subhash
CONTEXT: Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma. Factors that influence tobacco-exposed individuals developing a malignancy may include the combination of total tobacco exposure and genetic susceptibility. AIM: This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) null polymorphism in oral leukoplakia and oral squamous cell carcinoma patients in South Indian population...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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