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Oral dysplasia

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https://www.readbyqxmd.com/read/29337414/proliferative-leukoplakia-proposed-new-clinical-diagnostic-criteria
#1
Alessandro Villa, Reshma S Menon, Alexander R Kerr, Fabio De Abreu Alves, Andres Guollo, David Ojeda, Sook B Woo
OBJECTIVE: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathologic standpoint and suggest an updated classification. SUBJECTS AND METHODS: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathologic features, and malignant transformation (MT). RESULTS: There were 42 patients (median age: 69 years [range:36-88]; 35 females)...
January 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29333766/-relationship-between-different-x-ray-appearances-and-oral-clinical-manifestations-of-cemental-dysplasia
#2
Wang Hu
Cemental dysplasia is a non-neoplastic lesion and features different X-ray appearances that easily confuse dentists. This condition is often observed in conventional dental films or occasionally on panoramic radiographs. Cemental dysplasia is easily misdiagnosed as chronic periapical periodontitis, osteomyelitis, and tumor. In this paper, clinical mani-festations, imaging diagnosis, and the correlation between these variables are analyzed to achieve correct diagnosis.
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#3
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328386/proteomics-based-investigation-of-multiple-stages-of-oscc-development-indicates-that-the-inhibition-of-trx-1-delays-oral-malignant-transformation
#4
Xijuan Chen, Qinchao Hu, Tong Wu, Chunyang Wang, Juan Xia, Linglan Yang, Bin Cheng, Xiaobing Chen
The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation. However, no effective treatment approaches have been used to prevent the development of dysplasia into cancerous lesions thus far. In the present study, a well-established OSCC model was used to detect proteomics profiles at different stages during oral malignant transformation. Of the 15 proteins that were found to be upregulated in both the dysplasia and carcinoma stages, the oxidative stress-associated proteins, thioredoxin-1 (Trx-1), glutaredoxin-1 and peroxiredoxin-2 were note as the proteins with significant changes in expression Trx-1 was identified to be the most significantly upregulated protein in the precancerous stage...
January 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29299769/the-direct-medical-costs-of-diseases-associated-with-human-papillomavirus-infection-in-manitoba-canada
#5
Christiaan H Righolt, Gurpreet Pabla, Salaheddin M Mahmud
BACKGROUND: The total direct cost of screening and treating all human papillomavirus-related diseases (HPV-RD) has not been measured in a single study. Accurate cost estimates are needed to inform decisions on intervention priorities and evaluate the cost-effectiveness of existing programs. We used province-wide clinical, administrative, and accounting databases to measure direct medical costs of HPV infection in Manitoba (Canada). METHODS: All persons 9 years or older with health insurance coverage in Manitoba between April 2000 and March 2015 were eligible...
January 4, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29286215/inter-and-intra-observer-variability-in-diagnosis-of-oral-dysplasia
#6
Shubhasini A R, Praveen B N, Usha Hegde, Uma K, Shubha G, Keerthi G, Shiladitya Sil
Background: Oral potentially malignant disorders (OPMDs) are lesions from which malignancy is more likely to develop that from other tissues. The potential for malignant transformation of OPMDs is estimated by determining the degree of dysplastic changes in the epithelium. Dysplasia grading has been criticized for lack of reproducibility and poor predictive value but is still considered the gold standard for diagnosing OPMDs. Since grading of dysplasia is based on architectural and cytological changes, there can be considerable inter- and intra-observer variability due to subjective impressions...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29285334/bisphosphonates-therapy-in-children-with-osteogenesis-imperfecta-clinical-experience-in-oral-surgery
#7
G Ierardo, M Bossù, G D'Angeli, M Celli, G Sfasciotti
Objectives: To define the possible complications of oral surgery in childhood in patients affected by type 1 Osteogenesis imperfecta (OI) and treated with bisphosphonates (BP). Methods: The study was conducted among 20 patients in childhood with an age range 8-14 (12 ♂ e 8 ♀) affected by OI. Patients were initially evaluated at the Policlinico Umberto I, University Hospital of Rome, Rare Disease Center Skeletal Dysplasia-Bone Metabolic Pathologies and after at the Policlinico Umberto I, University Hospital of Rome, Head and Neck Department, UOC Pediatric Dentistry...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29284965/immunohistochemical-expression-of-ezrin-in-oral-potentially-malignant-disorders-a-descriptive-study
#8
Raghini Mohanraj, Pratibha Ramani, Priya Premkumar, Anuja Natesan, Herald J Sherlin, Gheena Sukumaran
Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Recent analysis reveals their involvement in signaling pathways. Ezrin is highly expressed in several types of human cancers, and correlation between its immunoreactivity and histopathological data as well as the patient outcome has previously been studied...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29280012/suox-is-negatively-associated-with-multistep-carcinogenesis-and-proliferation-in-oral-squamous-cell-carcinoma
#9
Ken Nakamura, Jun Akiba, Sachiko Ogasawara, Yoshiki Naito, Masamichi Nakayama, Yushi Abe, Jingo Kusukawa, Hirohisa Yano
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region. The aim of this study was to identify the key molecules and to elucidate the molecular mechanisms of OSCC carcinogenesis through a microarray analysis of RNA extracted from normal epithelium, dysplasia, and squamous cell carcinoma components. Out of molecules that showed changes in gene expression in the microarray analysis, we focused on Sulfite oxidase (SUOX), which correlated significantly with carcinogenic process and exhibited a stepwise decrease in expression...
December 26, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29276225/the-incidence-of-oral-and-oropharyngeal-cancers-in-betel-quid-chewing-populations-in-south-myanmar-rural-areas
#10
Nobuyoshi Mizukawa, Swe Swe Win, Zaw Moe Thein, Moe Thida Htwe, Yohsuke Yoshioka, Yoshihiro Kimata, Seiji Iida, Myo Khin, Shigeru Okada, Than Sein
Oral cancer is a very common disease in South and Southeast Asia. Betel quid (BQ)- chewing and tobaccosmoking habits are etiological factors for oral cancer patients in these regions. We conducted an oral cancer screening in BQ-chewing endemic rural areas in South Myanmar for the early detection of oral cancer in BQ-chewing and smoking individuals. We examined 105 subjects who were at high risk of oral cancer due to their oral habits (BQ users and/or smokers). Three carcinoma cases were detected, and there were 8 dysplasia cases...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29250055/the-microbiome-of-potentially-malignant-oral-leukoplakia-exhibits-enrichment-for-fusobacterium-leptotrichia-campylobacter-and-rothia-species
#11
Abdrazak Amer, Sheila Galvin, Claire M Healy, Gary P Moran
Oral leukoplakia presents as a white patch on the oral mucosa and is recognized as having significant malignant potential. Although colonization of these patches with Candida albicans is common, little is known about the bacterial microbiota of these patches. In the current study we analyzed the microbiome of oral leukoplakia in 36 patients compared to healthy mucosal tissue from the same patients and healthy control subjects to determine if specific microbial enrichments could be identified early in the malignant process that could play a role in the progression of the disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29243684/large-oral-ulcer-of-tongue-related-to-dental-trauma
#12
Gian Paolo Bombeccari, Gianpaolo Guzzi, Francesco Pallotti, Massimo Porrini, Aldo Bruno Giannì, Francesco Spadari
A 36-year-old Philippine male has a several month-history of burning pain of his tongue with lingual erythema and oral bleeding. Here we describe a classical case of oral chronic ulcer related to mechanical dental trauma. In this case, unilateral crossbite malocclusion was able to produce oral mucosal lesion that was sufficient to cause a large, chronic tongue ulcer and subsequent mild epithelial dysplasia. A specific tongue-retaining device was made. In absence of dental trauma, his chronic ulcer of the tongue resolved within a few weeks...
2017: Stomatologija
https://www.readbyqxmd.com/read/29243374/molecular-classification-of-autofluorescence-excision-margins-in-oral-potentially-malignant-disorders
#13
Camile S Farah, Farzaneh Kordbacheh, Keziah John, Nigel Bennett, Simon A Fox
OBJECTIVE: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles. MATERIALS AND METHODS: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other...
December 14, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29230691/beta-blocker-use-in-pregnancy-and-risk-of-specific-congenital-anomalies-a-european-case-malformed-control-study
#14
Jorieke E H Bergman, L Renée Lutke, Rijk O B Gans, Marie-Claude Addor, Ingeborg Barisic, Clara Cavero-Carbonell, Ester Garne, Miriam Gatt, Kari Klungsoyr, Nathalie Lelong, Catherine Lynch, Olatz Mokoroa, Vera Nelen, Amanda J Neville, Anna Pierini, Hanitra Randrianaivo, Anke Rissmann, David Tucker, Awi Wiesel, Helen Dolk, Maria Loane, Marian K Bakker
INTRODUCTION: The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy. OBJECTIVE: The objective of this study was to investigate whether first-trimester use of beta-blockers increases the risk of specific congenital anomalies in offspring. METHODS: A population-based case-malformed control study was conducted in 117,122 registrations of congenital anomalies from 17 European Concerted Action on Congenital Anomalies and Twins (EUROCAT) registries participating in EUROmediCAT with data for all or part of the period between 1995 and 2013...
December 11, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29224812/differential-roles-of-kallikrein-related-peptidase-6-in-malignant-transformation-and-%C3%AE-np63%C3%AE-mediated-epithelial-mesenchymal-transition-of-oral-squamous-cell-carcinoma
#15
Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224811/cancer-stem-cell-and-its-niche-in-malignant-progression-of-oral-potentially-malignant-disorders
#16
Subin Surendran, Gangotri Siddappa, Amrutha Mohan, Wesley Hicks, Vijayvel Jayaprakash, Christina Mimikos, Mohammed Mahri, Fatima Almarzouki, Kayla Morrell, Ravindra Ravi, Sindhu Govindan, C N Sushma, Nisheena Raghavan, Praveen Birur, Jeyaram Ilayaraja, Mihai Merzianu, Mary Reid, Amritha Suresh, Moni Abraham Kuriakose
OBJECTIVE: The purpose of this study was to determine association between cancer stem cells (CSCs) and their niche with progression of oral potentially malignant disorders. MATERIALS AND METHODS: Patients with histologically confirmed oral potentially malignant disorders, stratified into high/low risk lesions based on the degree of dysplasia and oral cancer were included in this study. Immunohistochemical profiling of markers of CSCs (CD44), endothelial cells (CD31) and CSC-vascular niche cross-talk (CXCR4 and SDF1) were carried out...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29222735/delayed-perforation-after-endoscopic-submucosal-dissection-treated-successfully-by-temporary-stent-placement
#17
Masami Omae, Magnus Konradsson, Francisco Baldaque-Silva
A 71-year-old male patient with a long-segment (C10M12) Barrett's esophagus harboring multifocal high-grade dysplasia was referred to our clinic. After a multidisciplinary team conference and the patient's informed consent, an endoscopic submucosal dissection (ESD) was performed with resection of 4/5 of the esophageal circumference along 12 cm, without any complications during or immediately after the procedure. In the day after the ESD, the patient presented suddenly with dyspnea and subcutaneous emphysema in the neck and chest...
December 8, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29216196/loss-of-epithelial-markers-is-an-early-event-in-oral-dysplasia-and-is-observed-within-the-safety-margin-of-dysplastic-and-t1-oscc-biopsies
#18
Zahra Abdalla, Tanya Walsh, Nalin Thakker, Christopher M Ward
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer that is associated with poor 5-year patient survival. Disease treatment is further compounded by the difficulty in predicting pre-cancerous tissues that will progress to OSCC and the high recurrence rates following surgical resection. Here we have assessed expression of the oral epithelial markers E-cadherin, EMP1 and 5T4 and the pro-invasive N-cadherin proteins using fully characterised antibodies and quantitative immunofluorescence microscopy in normal tissue (NT), fibroepithelial polyp (FEP), low-grade dysplasia (LGD), high-grade dysplasia (HGD), T1 OSCC and T4 OSCC biopsies...
2017: PloS One
https://www.readbyqxmd.com/read/29208932/mouse-papillomavirus-infection-persists-in-mucosal-tissues-of-an-immunocompetent-mouse-strain-and-progresses-to-cancer
#19
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Sarah A Brendle, Neil D Christensen, Todd D Schell, Jiafen Hu
Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains. In the current study, we examined mucosal infection in several immunocompetent and immunocompromised mouse strains. Viral DNA was monitored periodically by Q-PCR of lavage samples. Immunohistochemistry and in situ hybridization were used to determine viral capsid protein and viral DNA respectively. All athymic nude mouse strains showed active infections at both cutaneous and mucosal sites...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29201128/a-highlighted-case-for-emphasizing-on-clinical-diagnosis-for-rare-syndrome-in-third-world
#20
Fatemeh Owlia, Mohammad-Hassan Akhavan Karbassi, Roqayeh Hakimian, Mohammad Sadegh Alemrajabi
Premature tooth loss is a disastrous situation that affects deciduous or permanent teeth era with different causes. It may be attributed to some disorders like Papillon-Lefevre syndrome or coffin-lowry syndrome but because of ambiguous nature, precise diagnosis is not easily possible. Moreover, it has very low incidence and defines by few and limited case series, with vague characters to some extent, confusion in detecting the right diagnosis is a common possibility. Hence, it is expectable to have a wrong diagnosis for this case...
2017: Iranian Journal of Child Neurology
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