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https://www.readbyqxmd.com/read/28526593/cardiac-tamponade-as-an-initial-presentation-for-systemic-lupus-erythematosus
#1
William Li, Thomas Frohwein, Kenneth Ong
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease which follows a relapsing and remitting course that can manifest in any organ system. While classic manifestations consist of arthralgia, myalgia, frank arthritis, a malar rash and renal failure to name a few, cardiac tamponade, however, is a far less common and far more dangerous presentation. We highlight the case of a 61year-old male with complaints of acute onset shortness of breath and generalized body aches associated with a fever and chills in the ER...
April 29, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28522958/coexistence-of-ulcerative-colitis-and-sj%C3%A3-gren-s-syndrome-in-a-patient-with-takayasu-s-arteritis-and-hashimoto-s-thyroiditis
#2
Hyun Woo Park, Hyun Seok Lee, Sejin Hwang, Han Sol Lee, Han-Ik Bae, Ghilsuk Yoon
A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). She was treated with oral mesalazine, and her hematochezia symptoms subsequently disappeared. The coexistence of UC and TA has been reported; however, reports on the coexistence of UC and Sjögren's syndrome, or of UC and Hashimoto's thyroiditis are rare...
April 2017: Intestinal Research
https://www.readbyqxmd.com/read/28522918/combination-of-corticosteroids-and-5-aminosalicylates-or-corticosteroids-alone-for-patients-with-moderate-severe-active-ulcerative-colitis-a-global-survey-of-physicians-practice
#3
Shomron Ben-Horin, Jane M Andrews, Konstantinos H Katsanos, Florian Rieder, Flavio Steinwurz, Konstantinos Karmiris, Jae Hee Cheon, Gordon William Moran, Monica Cesarini, Christian D Stone, Doron Schwartz, Marijana Protic, Xavier Roblin, Giulia Roda, Min-Hu Chen, Ofir Har-Noy, Charles N Bernstein
AIM: To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates (5ASA) with corticosteroids (CS) versus corticosteroids alone for patients with active ulcerative colitis (UC). METHODS: A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28513869/transition-of-intravenous-treprostinil-to-oral-therapy-in-a-patient-with-functional-class-iv-chronic-thromboembolic-pulmonary-hypertension
#4
Kristina M Thurber, Breann M Williams, Ruth E Bates, Robert P Frantz
Chronic thromboembolic pulmonary hypertension (CTEPH) occurs when pulmonary emboli fail to resolve with anticoagulation. For patients with inoperable or residual CTEPH, riociguat is currently the only therapy approved by the United States Food and Drug Administration. However, some patients with CTEPH may require therapy beyond riociguat, such as intravenous prostacyclins, which can present significant administration challenges in patients with complex comorbid conditions. We describe a 42-year-old man with T12 paraplegia complicated by CTEPH (functional class IV with substantial right ventricular dysfunction) and severe pressure ulcers...
May 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28512605/toxicity-status-and-antiulcerative-potential-of-sansevieria-trifasciata-leaf-extract-in-wistar-rats
#5
Osasenaga Macdonald Ighodaro, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, Oyindamola Fuyi-Williams
AIMS: The lethal dose 50% (LD50) and antiulcerative potentials of Sansevieria trifasciata (ST) leaf extract were investigated. MATERIALS AND METHODS: LD50 was determined through two routes of administration (intraperitoneal [i.p] and oral [p.o]) using the method of Lorke. The antiulcerative activity was evaluated in indomethacin-induced ulcer model (40 mg/kg body weight [BW], i.p, single dose) against a reference drug, cimetidine (100 mg/kg BW, p.o). ST was assessed at two different doses (200 and 400 mg/kg BW, p...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512604/traditional-dentistry-knowledge-among-serbs-in-several-balkan-countries
#6
Dragan V Ilic, Biljana Andjelski Radicevic, Anely Nedelcheva, Ivana Djurovic, Dejan Ostojic
BACKGROUND/AIM: There are still unrevealed treasures of traditional dental medicine, that is, the reason to investigate and present various ways in treatment of oral and orofacial tissues, as well as magic and religious elements involved in representative areas among Serbs. MATERIALS AND METHODS: Information was collected from the elderly non-professional folk dentists and herbalists with the additional help of local physicians and dentists that was done through questionnaire and personal interviews...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512419/successful-treatment-of-primary-cutaneous-peripheral-t-cell-lymphoma-presenting-acquired-ichthyosis-with-oral-bexarotene-monotherapy
#7
Kayo Tanita, Taku Fujimura, Yota Sato, Takanori Hidaka, Sadanori Furudate, Yumi Kambayashi, Akira Tsukada, Akira Hashimoto, Setsuya Aiba
Acquired ichthyosis (AI) is a reactive cutaneous manifestation that can be associated with malignant hematological disease, including cutaneous T-cell lymphoma (CTCL). Since it is difficult to distinguish AI from ichthyosiform mycosis fungoides, to select the treatment for CTCL with ichthyosis-like appearance and to evaluate its efficacy is sometimes challenging. In this report, we describe a case of primary cutaneous peripheral T-cell lymphoma not otherwise specified presenting AI successfully treated with oral bexarotene...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28509325/an-alternative-approach-to-gynecological-wound-healing
#8
Jakub Rzepka, Katarzyna Mosoń, Romuald Dębski
An 89-year-old woman was reffered to our Clinic with vulvar cancer. She also suffered from obesity [with body mass index (BMI) 35 kg/m2], persistent hypertension, diabetes mellitus type 2 treated with oral medications. In 2015 she underwent a surgery due to endometrial carcinoma. Total abdominal hysterectomy with bilateral salphingoophorectomy, omentectomy and pelvical node dissection was performed (histopathology revealed adenocarcinoma serosum G2; FIGO stage Ib). In January 2016 after vulvar ulceration biopsy plano-epithelial squamous vulvar cancer was diagnosed...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28508238/surgical-excision-for-recurrent-herpes-simplex-virus-2-hsv-2-anogenital-infection-in-a-patient-with-human-immunodeficiency-virus-hiv
#9
Folasade Arinze, Aaron Shaver, Stephen Raffanti
Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences...
May 15, 2017: Infection
https://www.readbyqxmd.com/read/28507428/propranolol-therapy-for-infantile-hemangioma-our-experience
#10
Ling Zhang, Hai-Wei Wu, Weien Yuan, Jia-Wei Zheng
OBJECTIVE: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28506203/optimization-of-microemulsion-based-transdermal-gel-of-triamcinolone
#11
Bhagyashree Chaudhari, Swati Jagdale
BACKGROUND: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which causes inflammation. Triamcinolone has half-life of 88 minutes. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life. OBJECTIVE: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone...
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28502906/anti-inflammatory-effects-of-forsythia-suspensa-in-dextran-sulfate-sodium-induced-colitis
#12
Youn-Hwan Hwang, Dong-Gun Kim, Wei Li, Hye Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. MATERIALS AND METHODS: After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28501878/-oral-manifestations-of-ulcerative-colitis
#13
C X W Tan, H S Brand, N K H de Boer, T Forouzanfar
Ulcerative colitis is an inflammatory bowel disease occurring relatively frequently in industrialised regions of the world. Pyostomatitis vegetans is the most characteristic pathognomonic oral manifestation but other oral abnormalities like aphthous lesions, caries and periodontitis are more prevalent in patients with ulcerative colitis. Oral care providers must be aware of these problems if they are to provide adequate oral care.
May 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28501467/keratitis-by-a-rare-pathogen-colletotrichum-gloeosporioides-a-case-report
#14
S T Pote, A Chakraborty, K K Lahiri, M S Patole, R A Deshmukh, S R Shah
Colletotrichum species have been reported infrequently as the cause of keratitis or subcutaneous lesions. The patient we describe developed keratitis after ocular trauma. The sample from the corneal scrapings grew Colletotrichum gloeosporioides as identified from morphological characters and DNA sequence of the 'Internal Transcribed Spacer' (ITS) region. The patient underwent topical application of amphotericin-B followed by itraconazole and natamycin treatment. Simultaneous oral voriconazole regimen leads to complete regression of corneal ulcer...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28500815/oral-pentoxifylline-associated-with-pentavalent-antimony-a-randomized-trial-for-cutaneous-leishmaniasis
#15
Graça Brito, Mayra Dourado, Luiz Henrique Guimarães, Everson Meireles, Albert Schriefer, Edgar Marcelino de Carvalho, Paulo Roberto Lima Machado
AbstractCutaneous leishmaniasis (CL) by Leishmania braziliensis is associated with decreasing cure rates in Brazil. Standard treatment with pentavalent antimony (Sb(v)) cures only 50-60% of the cases. The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production. Pentoxifylline, a TNF inhibitor, has been successfully used in association with Sb(v) in mucosal and cutaneous leishmaniasis. This randomized, double-blind, and placebo-controlled trial aimed to evaluate the efficacy and safety of oral pentoxifylline plus Sb(v) versus placebo plus Sb(v) in patients with CL in Bahia, Brazil...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28499754/methotrexate-induced-epidermal-necrosis-a-case-series-of-24-patients
#16
Ting-Jui Chen, Wen-Hung Chung, Chun-Bing Chen, Rosaline Chung-Yee Hui, Yu-Huei Huang, Yueh-Tsung Lu, Chang-Wei Wang, Kuo-Hsien Wang, Li-Cheng Yang, Shuen-Iu Hung
BACKGROUND: Methotrexate-induced epidermal necrosis (MEN) is a rare but life-threatening cutaneous reaction that mimics Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). OBJECTIVES: To investigate the clinicopathology, risk factors, and prognostic factors of MEN. METHODS: We enrolled 24 patients with MEN and 150 controls and analyzed the demographics, pathology, and plasma concentrations of methotrexate (MTX). RESULTS: Patients with MEN showed extensive skin necrosis (mean, 33...
May 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28499407/early-neurosyphilis-presenting-with-facial-palsy-and-an-oral-ulcer-in-a-patient-who-is-human-immunodeficiency-virus-positive-a-case-report
#17
Evangeline Njiru, Jamil Abdulkadir, Zipporah Kamuren, Gabriel Kigen
BACKGROUND: Neurosyphilis is the tertiary stage of Treponema pallidum infection that involves the central nervous system, which occurs within days or weeks after an initial syphilis infection, especially in immunocompromised patients. The diagnosis of neurosyphilis is quite challenging as it is uncommon and often presents with obscure symptoms since any organ system may be involved. CASE PRESENTATION: We describe a case of a 40-year-old African man who is human immunodeficiency virus positive with early neurosyphilis who presented with a stiff neck, headache, confusion, restlessness, and a left-sided chest pain; he did not respond to an empiric treatment of ceftriaxone and fluconazole for meningitis, and tramadol for headache...
May 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28498931/protective-effects-of-hot-spring-water-drinking-and-radon-inhalation-on-ethanol-induced-gastric-mucosal-injury-in-mice
#18
Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka
Radon therapy using radon (222Rn) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice...
May 12, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28498781/phase-i-study-and-biomarker-analysis-of-pyrotinib-a-novel-irreversible-pan-erbb-receptor-tyrosine-kinase-inhibitor-in-patients-with-human-epidermal-growth-factor-receptor-2-positive-metastatic-breast-cancer
#19
Fei Ma, Qiao Li, Shanshan Chen, Wenjie Zhu, Ying Fan, Jiayu Wang, Yang Luo, Puyuan Xing, Bo Lan, Meiying Li, Zongbi Yi, Ruigang Cai, Peng Yuan, Pin Zhang, Qing Li, Binghe Xu
Purpose This phase I study assessed the safety, tolerability, pharmacokinetics, antitumor activity, and predictive biomarkers of pyrotinib, an irreversible pan-ErbB inhibitor, in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. Patients and Methods Pyrotinib was administered continuously, orally, once per day to patients who did not have prior exposure to tyrosine kinase inhibitors of HER2. Planned dose escalation was 80, 160, 240, 320, 400, and 480 mg. For pharmacokinetic analysis, timed blood samples were collected on day 1 and day 28...
May 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28498563/identification-of-factors-associated-with-treatment-refractoriness-of-oral-lesions-in-pemphigus-vulgaris
#20
S Kumar, D De, S Handa, R K Ratho, S Bhandari, A Pal, P Kamboj, S Sarkar
BACKGROUND: Oral mucosal lesions of pemphigus vulgaris (PV) are known to show more treatment refractoriness than skin lesions. OBJECTIVES: To identify the role of different clinical and laboratory parameters in the treatment refractoriness in the oral lesions of PV. METHODS: This prospective study recruited 50 adult patients of PV having oral lesions. Patients were given treatment appropriate for overall disease severity. Treatment refractoriness was defined arbitrarily as less than 75% reduction in oral objective Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) after treatment for 6 months...
May 12, 2017: British Journal of Dermatology
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