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https://www.readbyqxmd.com/read/29456770/recurrent-oral-eosinophilic-ulcers-of-the-oral-mucosa-a-case-report
#1
Norberto Sugaya, Fernanda Martignago, Decio Pinto, Dante Migliari
Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman. Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29456618/an-unusual-presentation-of-adult-t-cell-leukemia-lymphoma
#2
Mohammed Tag-Adeen, Keiichi Hashiguchi, Yuko Akazawa, Ken Ohnita, Sawayama Yasushi, Niino Daisuke, Kazuhiko Nakao
Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29455070/oral-engineered-bifidobacterium-longum-expressing-rhmnsod-to-suppress-experimental-colitis
#3
Mengge Liu, Shiyu Li, Qian Zhang, Zhenrui Xu, Jiajia Wang, Hanxiao Sun
In recent years, using genetic engineering and bioengineering techniques, Bifidobacterium as a carrier to express specific functions of the protein or polypeptide, has become a new treatment for disease. Ulcerative colitis (UC) is a type of inflammatory bowel diseases (IBD). Although the cause of this inflammatory disorder is still unknown, a large amount of evidence suggests that ulcerative colitis is associated with increased activity of reactive oxygen species (ROS), manganese superoxide dismutase (MnSOD) is a kind of superoxide dismutase (SOD) has been demonstrated to play a key role in the pathophysiology of colitis...
February 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29447591/characterization-of-a-partial-body-irradiation-model-with-oral-cavity-shielding-in-non-human-primates
#4
Michael V Accardi, Oreola Donini, Adam Rumage, Alexis Ascah, Julius Haruna, Mylène Pouliot, Kim Bujold, Hai Haung, Wieslaw Wierzbicki, John Stamatopoulos, Houman Naraghi, Thomas Measey, Simon Authier
PURPOSE: Characterization of a novel partial body irradiation (PBI) shielding strategy in nonhuman primates (NHP; rhesus macaques), aimed at protecting the oral cavity, with respect to various gastrointestinal (GI-ARS) syndrome parameters as well as buccal ulceration development. MATERIALS AND METHODS: NHPs were irradiated using a Cobalt-60 gamma source, in a single uniform dose, ranging from 9-13 Gy and delivered at 0.60-0.80 Gy min -1 . Animals were either partially shielded via oral cavity shielding (PBI OS ) or underwent total body irradiation (TBI)...
February 15, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29447319/squamous-cell-carcinoma-of-the-gingiva-mimicking-periodontal-disease-a-diagnostic-challenge-and-therapeutic-dilemma
#5
Michael M Bornstein, Claude Andreoni, Thomas Meier, Yiu Yan Leung
A case of squamous cell carcinoma of the gingiva (GSCC) in the left anterior maxilla in a 64-year-old woman that was treated for almost 5 years as suspected periodontal lesion prior to establishing the final diagnosis of oral cancer is presented in this case report. GSCCs have a variable clinical appearance, ranging from an exophytic mass to ulcerative lesions. They have been reported to pose a diagnostic challenge and are not infrequently initially misdiagnosed as periodontal disease. A delay in diagnosis and extraction of teeth in the vicinity of GSCCs has been demonstrated to increase the risk for lymph node metastasis and thus result in a lower 5-year survival rate...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29445104/genetic-modification-to-induce-cxcr2-overexpression-in-mesenchymal-stem-cells-enhances-treatment-benefits-in-radiation-induced-oral-mucositis
#6
Zongshan Shen, Jiancheng Wang, Qiting Huang, Yue Shi, Zhewei Wei, Xiaoran Zhang, Yuan Qiu, Min Zhang, Yi Wang, Wei Qin, Shuheng Huang, Yinong Huang, Xin Liu, Kai Xia, Xinchun Zhang, Zhengmei Lin
Radiation-induced oral mucositis affects patient quality of life and reduces tolerance to cancer therapy. Unfortunately, traditional treatments are insufficient for the treatment of mucositis and might elicit severe side effects. Due to their immunomodulatory and anti-inflammatory properties, the transplantation of mesenchymal stem cells (MSCs) is a potential therapeutic strategy for mucositis. However, systemically infused MSCs rarely reach inflamed sites, impacting their clinical efficacy. Previous studies have demonstrated that chemokine axes play an important role in MSC targeting...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445030/cabozantinib-in-patients-with-advanced-merkel-cell-carcinoma
#7
Guilherme Rabinowits, Cecilia Lezcano, Paul J Catalano, Patricia McHugh, Hailey Becker, Megan M Reilly, Julian Huang, Ayushi Tyagi, Manisha Thakuria, Scott C Bresler, Lynette M Sholl, Geoffrey I Shapiro, Robert Haddad, James A DeCaprio
BACKGROUND: This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC). EXPERIMENTAL DESIGN: This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Secondary endpoints included overall survival (OS), progression-free survival (PFS), and toxicity...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29443756/ulcerative-colitis-followed-by-the-development-of-typical-intestinal-beh%C3%A3-et-disease-a-case-report
#8
Zhenhua Zhu, Xu Shu, Shunhua Long, Xiaozhen Jiang, Nonghua Lu, Xuan Zhu, Wangdi Liao
RATIONALE: Intestinal Behçet disease (intestinal BD) and inflammatory bowel disease (IBD) share a lot of characteristics, including genetic background, clinical manifestations, and therapeutic strategies, especially the extraintestinal manifestations, such as oral ulcers, arthralgia, eye lesions, skin lesions, etc, but the coexistence of these 2 diseases are uncommon. Behçet disease with gastrointestinal involvement in ulcerative colitis (UC) patient has been reported in just 1 previous case report, but, which can not be diagnosed as definite intestinal BD based on Korean novel diagnositic criteria due to lacking the typical ileocecal ulcer...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442455/oral-mucositis-and-saliva-iga-igg-and-igm-concentration-during-anti-tumor-treatment-in-children-suffering-from-acute-lymphoblastic-leukemia
#9
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29440893/nanoemulsion-as-a-strategy-for-improving-the-oral-bioavailability-and-anti-inflammatory-activity-of-andrographolide
#10
Ching-Chi Yen, Yi-Chen Chen, Ming-Tsang Wu, Chia-Chi Wang, Yu-Tse Wu
Background: Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflammatory bowel disease. Methods: A high-pressure homogenization technique was used to prepare the AG-NE and solubility, viscosity, and droplet size tests were conducted to develop the optimized AG-NE composed of α-tocopherol, ethanol, Cremophor EL, and water...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29435324/efficacy-and-safety-of-a-novel-high-dose-mesalazine-tablet-in-mild-to-moderate-active-ulcerative-colitis-a-double-blind-multicentre-randomised-trial
#11
Axel Dignass, Robert Schnabel, Jacek Romatowski, Vladimir Pavlenko, Andrey Dorofeyev, Jelena Derova, Laimas Jonaitis, Karin Dilger, Tanju Nacak, Roland Greinwald
Background: Adherence to mesalazine treatment is essential for the successful treatment of ulcerative colitis. Objective: The objective of this study was to compare the efficacy, safety and preference of a novel high-dose 1000 mg mesalazine tablet versus conventional treatment for ulcerative colitis remission. Methods: This pivotal phase III trial compared one 1000 mg mesalazine tablet (M1000 group) versus two registered 500 mg mesalazine tablets (M2x500 group), both taken three times daily, in patients with mild to moderately active ulcerative colitis...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29432959/impact-of-adverse-event-solicitation-on-the-safety-profile-of-sq-house-dust-mite-sublingual-immunotherapy-tablet
#12
Hendrik Nolte, David I Bernstein, Gordon L Sussman, Bodil Svanholm Fogh, Susan Lu, Bernt Husøy, Harold S Nelson
BACKGROUND: It has been recommended that sublingual immunotherapy (SLIT) safety be assessed using solicited adverse event (AE) collection methods. OBJECTIVES: To describe the impact on the safety profile of SQ house dust mite (HDM) SLIT-tablet (12 SQ-HDM dose) when pre-specified local application site reactions were solicited vs unsolicited, and discuss ramifications of AE solicitation. METHODS: Subjects were randomized to daily 12 SQ-HDM or placebo for up to 52 weeks in 4 double-blinded, multicenter trials...
February 9, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29430677/cutaneous-refractile-foreign-body-microemboli-with-intravascular-injection-of-oral-medication
#13
Nicholas Bercovici, Kristen Russomanno, Frank Santoro, Christopher Scola, Michael Murphy, Zendee Elaba
Injection drug abuse (IDA) is known to cause a spectrum of systemic and cutaneous complications. Despite the increasing incidence of IDA around the world, there is a paucity of literature discussing cutaneous complications from a dermatopathologic perspective. We present a case of a 35-year-old male with a complex medical history of Von Willebrand disease, Behcet's disease and diverticular disease. Following a sigmoidectomy/colostomy for diverticular perforation, he presented with fever and an indurated right arm displaying livedoid purpura...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29430432/hughes-stovin-syndrome-as-an-outcome-of-beh%C3%A3-et-disease-or-as-a-different-entity
#14
Serkan Demirkan, Yıldırım Gültekin
Hughes-Stovin syndrome is a rare disorder of unknown etiology. Although the association between multiple pulmonary artery aneurysms and venous thrombosis of the lower limbs was reported by Beattie and Hall in 1911, it was not until 1962 that the eponym "Hughes-Stovin syndrome" was formally introduced in the medical literature. We describe 2 patients with Hughes-Stovin syndrome who presented with pulmonary artery aneurysm, thrombophlebitis, hemoptysis, and oral ulcers, review the manifestations of the disease, and compare its similarities with and differences from Behçet disease...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29425752/management-of-facial-pyoderma-gangrenosum-using-platelet-rich-fibrin-a-technical-report
#15
Leonzio Fortunato, Selene Barone, Francesco Bennardo, Amerigo Giudice
This report describes a case of local pyoderma gangrenosum that was treated with short-term immunosuppressive therapy and the topical application of platelet-rich fibrin (PRF). Medical treatment included oral corticosteroid therapy and topical treatment with PRF in solid and liquid form. This therapy initially led to the reduction of the ulcer's size and an improvement in symptoms, until the ulcer was completely healed after a few weeks. A relapse was treated with only the application of PRF to the affected tissue with excellent recovery...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29424482/zinc-deficiency-like-syndrome-in-fleckvieh-calves-clinical-and-pathological-findings-and-differentiation-from-bovine-hereditary-zinc-deficiency
#16
M C Langenmayer, S Jung, M Majzoub-Altweck, F M Trefz, C Seifert, G Knubben-Schweizer, R Fries, W Hermanns, N S Gollnick
BACKGROUND: Zinc deficiency-like (ZDL) syndrome is an inherited defect of Fleckvieh calves, with striking similarity to bovine hereditary zinc deficiency (BHZD). However, the causative mutation in a phospholipase D4 encoding gene (PLD4) shows no connection to zinc metabolism. OBJECTIVES: To describe clinical signs, laboratory variables, and pathological findings of ZDL syndrome and their utility to differentiate ZDL from BHZD and infectious diseases with similar phenotype...
February 9, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29422828/vitamin-d-status-in-recurrent-aphthous-stomatitis
#17
Ewa Krawiecka, Zuzanna Ślebioda, Elżbieta Szponar, Anna Kowalska, Barbara Dorocka-Bobkowska
Introduction: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease. Aim: To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Material and methods: Sixty-six patients with RAS and 66 controls were examined...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29422724/effect-of-continuous-versus-intermittent-subglottic-suctioning-on-tracheal-mucosa-by-the-mallinckrodt-taperguard-evac-oral-tracheal-tube-in-intensive-care-unit-ventilated-patients-a-prospective-randomized-study
#18
Philippe Seguin, Harmonie Perrichet, Estelle Le Pabic, Yoann Launey, Marie Tiercin, Romain Corre, Graziella Brinchault, Bruno Laviolle
Background and Aims: A risk of tracheal mucosa injury induced by subglottic suctioning has been raised. Therefore, this prospective randomized study aims to compare the effect of continuous suctioning of subglottic secretions versus intermittent suctioning of subglottic secretions (CSSS vs. ISSS) secretions on tracheal mucosa in front of the suctioning port of the endotracheal tube. Patients and Methods: Patients requiring intubation or reintubation in Intensive Care Unit with an expected ventilation duration > 24 h were eligible...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29422033/a-case-report-of-tubo-ovarian-abscess-caused-by-burkholderia-pseudomallei
#19
Pattaranit Nernsai, Areepan Sophonsritsuk, Srithean Lertvikool, Artit Jinawath, Maria Nina Chitasombat
BACKGROUND: Melioidosis, the disease caused by Burkholderia pseudomallei is endemic in the Northeastern part of Thailand, South-East Asia, and Northern Australia. The pelvic involvement of disease is rare even in an endemic area. Therefore, we describe in this report the clinical presentation, management, and outcome of the patient with primary tubo-ovarian abscess due to melioidosis. CASE PRESENTATION: A 31-year-old Thai cassava farmer woman presented with fever and abdominal pain at left lower quadrant for one month...
February 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29417856/gastrointestinal-safety-and-tolerability-of-oral-non-aspirin-over-the-counter-analgesics
#20
Nicholas Moore, James M Scheiman
Over-the-counter (OTC) analgesics are routinely used worldwide for self-management of various painful conditions. Despite this, there has been little in-depth review of the safety of non-aspirin analgesics at OTC doses. This paper reviews the available literature on the gastrointestinal (GI) and hepatic safety of non-aspirin OTC analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, diclofenac, and naproxen) and acetaminophen; safety in overdose is also reviewed. Each non-aspirin OTC analgesic has a distinct adverse event (AE) profile, with GI AE rates for OTC dosing in one study ranging from 37% for diclofenac to 7...
February 8, 2018: Postgraduate Medicine
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