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https://www.readbyqxmd.com/read/29040035/long-term-efficacy-and-safety-of-interferon-alpha-2a-in-the-treatment-of-chinese-patients-with-beh%C3%A3-et-s-uveitis-not-responding-to-conventional-therapy
#1
Peizeng Yang, Guo Huang, Liping Du, Zi Ye, Ke Hu, Chaokui Wang, Jian Qi, Liang Liang, Lili Wu, Qingfeng Cao, Aize Kijlstra
PURPOSE: To investigate the long-term efficacy and safety of interferon alpha-2a (IFNα-2a) in Chinese patients with Behçet's uveitis (BU) refractory to conventional therapy. METHODS: In a prospective observational cohort study, 127 patients were treated with an initial dosage of 3 million units per day in the first three months, followed by gradual tapering of the dose. RESULTS: After 3 months of treatment, IFNα-2a was shown to be effective in 115 cases (91%)...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29036968/-the-458th-case-fever-cytopenia-abdominal-pain-and-multiple-intestinal-ulcerations-with-perforation
#2
Y Lin, H H Xie, W Zhao, M Wu, W Y Gu
Trisomy 8 in myelodysplastic syndrome (MDS) plays an important role in concurrent intestinal Behçet's disease (BD) pathogenesis. Here, we reported a case of intestinal BD combined with MDS involving trisomy 8. A 48-year-old woman who has had a 20-year history of recurrent oral ulcer, perineal ulcer and iris, was diagnosed as MDS with trisomy 8 four years ago. She developed high fever and acute abdominal pain. Multiple ulcerative perforations in ileum and colon were found by endoscopy, meeting the criteria for intestinal BD...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29033819/an-unusual-presentation-of-pyoderma-gangrenosum-leading-to-systemic-inflammatory-response-syndrome
#3
Ali Didan, Alan Donnelly, Hock Chua
This is a report of an atypical presentation of pyoderma gangrenosum (PG) in a 26-year-old male who had a negative septic screen. The patient had a life-threatening presentation requiring an intensive care unit (ICU) admission for vasopressor support. It was thought that the likely cause of circulatory collapse was an overwhelming cytokine reaction or systemic inflammatory response syndrome (SIRS) secondary to extensive PG lesions rather than septic shock. The patient presented with multiple large ulcers, the largest being 4 cm in diameter on the central chest...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033763/multiple-small-intestine-ulcers-with-desquamation-of-the-fingers
#4
Azusa Kawasaki, Kunihiro Tsuji, Hisashi Doyama
A 73-year-old female was admitted to our hospital with abdominal pain and diarrhea. Computed tomography detected distension of the small intestine. A palmar erythema, multiple oral ulcers, and desquamation of the fingers appeared after hospitalization. Small-bowel endoscopic images showed multiple ulcers. We attributed this case to infection with Yersinia pseudotuberculosis based on the changes in Y. pseudotuberculosis antibody titers throughout the course of the illness. This report is valuable, as it illustrates the endoscopic characteristics of a Y...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29032119/a-systematic-review-of-safety-and-efficacy-of-systemic-corticosteroids-in-atopic-dermatitis
#5
Sherry Yu, Aaron M Drucker, Mark Lebwohl, Jonathan I Silverberg
BACKGROUND: Systemic corticosteroids are often used to treat atopic dermatitis (AD). However, few studies assessed the safety and efficacy of systemic corticosteroids in AD. OBJECTIVE: To systematically review the literature on efficacy and safety of systemic corticosteroid use (oral, intramuscular, intravenous) in AD. METHODS: PubMed, Embase, Medline, Scopus, Web of Science, and Cochrane Library were searched. We included systematic reviews, guidelines and treatment reviews of systemic corticosteroid use among patients of all ages with a diagnosis of AD (52 reviews and 12 studies)...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29028981/tofacitinib-in-patients-with-ulcerative-colitis-health-related-quality-of-life-in-phase%C3%A2-3-randomized-controlled-induction-and-maintenance-studies
#6
Julian Panés, Séverine Vermeire, James O Lindsay, Bruce E Sands, Chinyu Su, Gary Friedman, Haiying Zhang, Aaron Yarlas, Martha Bayliss, Stephen Maher, Joseph C Cappelleri, Andrew G Bushmakin, David T Rubin
Background and Aims: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for UC. We evaluated healthrelated quality of life [HRQoL] in tofacitinib UC Phase 3 studies. Methods: Patients ≥18 years old in OCTAVE Induction 1 [N=598] and 2 [N=541] with moderately to severely active UC were randomized [1:4] to placebo or tofacitinib 10mg twice daily [BID] for 8 weeks. Subsequently, OCTAVE Sustain re-randomized [1:1:1] clinical responders [N=593] from induction studies to placebo, tofacitinib 5 or 10mg BID for 52 weeks...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29026519/squamous-cell-carcinoma-arising-in-familial-gingival-fibromatosis-a-rare-case-report
#7
Dilasma Ghartimagar, Ujjwal Koirala, Arnab Ghosh, Manish Kiran Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
Familial gingival fibromatosis is a rare hereditary condition due to chromosomal abnormality which can occur as an isolated disease or as part of a syndrome and has an incidence of 1:350 000. This condition leads to esthetic, functional, psychological and masticatory disturbance of the oral cavity. Here, we present a case of 21-year-old female with severe enlargement of gums in maxilla and mandible. Deciduous teeth were erupted at normal age but the permanent teeth in the oral cavity were not erupted. Her grandmother, father and younger sister were also affected with the same condition...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29026416/right-ventricular-thrombosis-as-a-manifestation-of-beh%C3%A3-et-s-syndrome
#8
Payam Ebrahimifar, Javad Shahabi
BACKGROUND: Behçet's disease (BD) is a rare condition with a classic triad of oral and genital ulceration and eye disease. Cardiovascular complication is a rare finding in BD. CASE REPORT: In this report, we present a seventeen years old patient with a history of fever for 20 days, who developed a clot in right ventricle (RV). Cardiac magnetic resonance imaging (MRI) and echocardiography demonstrated a thrombosis in RV and a thoracic multi detector computed tomographic image showed pulmonary thromboembolism (PTE) in patient...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29020192/single-dose-azithromycin-for-the-treatment-of-haemophilus-ducreyi-skin-ulcers-in-papua-new-guinea
#9
Camila González-Beiras, August Kapa, Marti Vall Mayans, Raymond Paru, Sergi Gavilán, Wendy Houinei, Sibauk Bieb, Sergi Sanz, Rosario Martíns, Oriol Mitjà
Background: Haemophilus ducreyi (HD) and Treponema pallidum subsp. pertenue (TP) are major causative agents of cutaneous ulcers (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in-vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of single oral dose azithromycin on HD-CU. Methods: We conducted a community-based cohort study in Lihir Island, Papua New Guinea, from October 2014 through May 2016...
August 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#10
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994526/-research-progress-of-baizhu-shaoyao-powder-in-treating-ulcerative-colitis
#11
REVIEW
Yang-Yang Xu, Hao Cai, Yu Duan, Ke Pei, Kai-Lei Fan, Xiao Liu, Gang Cao
Ulcerative colitis is a chronic, nonspecific and complex intestinal disease. The current clinical treatment guideline of this disease recommends a variety of options with oral western medicines, such as aminosalicylic acids, glucocorticosteroids, and immunosuppressors. However, due to their unstable therapeutic effects, high toxicities, and strong drug dependence, they are not suitable for long-term administration. Baizhu Shaoyao powder, a traditional Chinese medicinal prescription, is clinically and commonly used for tonifying spleen and softening liver as well as eliminating dampness and relieving diarrhea...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28993978/anemia-in-patients-with-ulcerative-colitis-in-remission-a-study-from-western-india
#12
Alisha Chaubal, Vikas Pandey, Dhaval Choksi, Prateik Poddar, Meghraj Ingle, Aniruddha Phadke, Prabha Sawant
BACKGROUND: Anemia is common in patients with active ulcerative colitis. We aimed to study the anemia profile in patients with ulcerative colitis in clinical remission. METHODS: Sixty-four patients with ulcerative colitis and with a clinical Mayo score less than 3 for at least 3 months were evaluated for anemia. Initial screening was done by hemogram and only patients with anemia were evaluated further for the cause of anemia. We also screened a control population for anemia...
October 9, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28993276/a-distinctive-subgroup-of-oral-ebv-b-cell-neoplasm-with-polymorphous-features-is-potentially-identical-to-ebv-mucocutaneous-ulcer
#13
Yae Ohata, Anna Tatsuzawa, Yoshio Ohyama, Ayako Ichikawa, Yumi Mochizuki, Sachiko Ishibashi, Yuri Itakura, Kei Sakamoto, Tohru Ikeda, Masanobu Kitagawa, Kouhei Yamamoto
EBV-positive mucocutaneous ulcer (EBVMCU) is a newly recognized provisional entity, included in mature B-cell neoplasm in the latest 2016 World Health Organization Classification. It has a self-limited growth potential with a high predilection for oral cavities, and occurs in age-related or iatrogenic immunodeficiency with indolent clinical courses. However, it shares histological features with EBV-positive diffuse large B-cell lymphoma (DLBCL), and this often leads to diagnostic challenges and controversies in patients with an oral EBV-positive B-cell neoplasm...
October 6, 2017: Human Pathology
https://www.readbyqxmd.com/read/28990694/suprafascial-versus-traditional-harvesting-technique-for-free-antero-lateral-thigh-flap-a-case-control-study-to-assess-the-best-functional-and-aesthetic-result-in-extremity-reconstruction
#14
Michele Maruccia, Nefer Fallico, Emanuele Cigna, Pedro Ciudad, Fabio Nicoli, Emilio Trignano, Eleonora Nacchiero, Giuseppe Giudice, Diego Ribuffo, Hung-Chi Chen
Clinical applications of ALT flap have currently extended to extremity (hand and foot) as well as oral cavity reconstruction. In these anatomical areas, the traditional harvesting technique presents a few disadvantages such as bulkiness of the recipient site and potential donor site morbidity including damage to the deep fascia and skin graft adhesions. The purpose of the present study was to compare the functional and aesthetic outcomes of upper and lower extremity reconstruction with either suprafascial or subfascial harvested anterolateral (ALT) flaps...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28990239/tacrolimus-therapy-for-dermal-arteritis-of-the-nasal-philtrum-refractory-to-surgery-and-anti-inflammatory-therapy-doxycycline-niacinamide-and-topical-fluocinolone-in-a-dog
#15
Frane Banovic, Carmen Jerry, Elizabeth Howerth
BACKGROUND: Dermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs. OBJECTIVE: To describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog. ANIMAL: A 9-year-old, intact male German shorthair pointer dog was presented with well-demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage...
October 8, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28988395/effect-of-roxithromycin-on-mucosal-damage-oxidative-stress-and-pro-inflammatory-markers-in-experimental-model-of-colitis
#16
Hilal Ahmad, Sneh Verma, Vijay L Kumar
OBJECTIVE AND DESIGN: Roxithromycin, a macrolide antibiotic, exhibits anti-inflammatory property. The present study was designed to evaluate its protective effect in a rat model of colitis. METHODS: The anti-inflammatory property of roxithromycin was first validated in rat paw edema model at 5 and 20 mg/kg doses where it produced 19 and 51% inhibition of paw swelling induced by carrageenan. The efficacy of roxithromycin was evaluated at these doses in a rat model where colitis was induced by intra-colonic instillation of acetic acid...
October 7, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28984645/advances-in-the-endoscopic-management-of-gastric-outflow-disorders
#17
Andrew C Storm, Marvin Ryou
PURPOSE OF REVIEW: Disorders of gastric outflow and outlet obstruction include a variety of benign and malignant disorders such as peptic strictures, foreign bodies, gastroparesis, and cancers of the stomach, duodenum, and pancreas. Historically, a majority of patients presenting with gastric outlet obstruction (GOO) were to the result of peptic ulcers and surgical management of peptic ulcer complications was a mainstay of general surgical training. Invasive surgery is being performed less frequently today due to realization of the role of Helicobacter pylori in peptic ulcer disease and the introduction of novel endoscopic techniques for management of GOO...
November 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28983850/topical-administration-of-ibuprofen-for-injured-athletes-considerations-formulations-and-comparison-to-oral-delivery
#18
REVIEW
Martin Anthony Christopher Manoukian, Christopher William Migdal, Amode Ravindra Tembhekar, Jerad Alexander Harris, Charles DeMesa
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs commonly used to treat both the acute and chronic injuries sustained by athletes during training and competition. In many parts of the world, NSAIDs can be purchased over-the-counter and used without any physician oversight. However, the chronic nature of overuse injuries requires NSAIDs to be taken orally for an extended period of time. As a result, they can have significant adverse effects on athletes, namely gastrointestinal (GI), renal, and cardiovascular damage...
October 5, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28980911/acute-oral-tetrahydrobiopterin-administration-ameliorates-endothelial-dysfunction-in-systemic-sclerosis
#19
Daniel R Machin, Heather L Clifton, Russell S Richardson, D Walter Wray, Anthony J Donato, Tracy M Frech
OBJECTIVES: Systemic sclerosis (SSc) is a rare, autoimmune disease characterised by endothelial dysfunction, which is associated with peripheral vasculopathy, such as digital ulcers (DU). We sought to determine if acute oral administration of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase, would augment endothelial function in patients with SSc. METHODS: Twelve SSc patients, of whom a majority had a history of DU, were studied 5 hours after oral BH4 administration (10 mg/kg body mass) or placebo on separate days using controlled, counterbalanced, double-blind, crossover experimental design...
September 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28979324/protective-effect-of-a-polyherbal-traditional-formula-consisting-of-rosa-damascena-mill-glycyrrhiza-glabra-l-and-nardostachys-jatamansi-dc-against-ethanol-induced-gastric-ulcer
#20
Zahra Memariani, Mannan Hajimahmoodi, Bagher Minaee, Fariba Khodagholi, Asal Yans, Roja Rahimi, Gholamreza Amin, Ghazaleh Moghaddam, Tayebeh Toliyat, Mohammad Sharifzadeh
"VARD" formula consisting of Rosa damascena Mill. (Rosaceae) petals, and rhizomes of Glycyrrhiza glabra L. (Papilionaceae) and Nardostachys jatamansi DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular functions of extracts were also evaluated. Each plant hydroalcoholic extract was standardized via determination of total phenolic and flavonoid contents, also via some phenolic compounds determination and specially glycyrrhizic acid in G...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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