keyword
MENU ▼
Read by QxMD icon Read
search

Oral ulcer

keyword
https://www.readbyqxmd.com/read/29674247/apple-peel-polyphenols-reduce-mitochondrial-dysfunction-in-mice-with-dss-induced-ulcerative-colitis
#1
Pantea Rahmani Yeganeh, Jade Leahy, Schohraya Spahis, Natalie Patey, Yves Desjardins, Denis Roy, Edgard Delvin, Carole Garofalo, Jean-Philippe Leduc-Gaudet, David St-Pierre, Jean-François Beaulieu, André Marette, Gilles Gouspillou, Emile Levy
Inflammatory bowel diseases (IBDs) are multifaceted and relapsing immune disorders, which necessitate long-term dependence on powerful drugs. As the use of natural product-based therapies has emerged as a promising intervention, the present study aimed to further characterize dried apple peel powder (DAPP) mechanisms of action and evaluate the preventive and curative effects of DAPP on mitochondrial functions in a murine model. Induction of intestinal inflammation in mice is performed by oral administration of the dextran sodium sulfate (DSS) at 2...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29673751/-primary-cutaneous-cd30-t-cell-lymphoproliferation-during-treatment-with-fingolimod-case-report-and-literature-review
#2
E Cesbron, J-B Monfort, C Giannesini, P Duriez, P Moguelet, P Senet, C Francès, A Barbaud, F Chasset
BACKGROUND: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. PATIENTS AND METHODS: A 56-year-old woman developed cutaneous indurated and ulcerated nodular lesions 6 months after starting fingolimod for active relapsing-remitting multiple sclerosis...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673551/antiulcer-and-hepatoprotective-effects-of-aqueous-extract-of-plantago-ovata-seed-on-indomethacin-ulcerated-rats
#3
Seyyed Majid Bagheri, Fatemeh Zare-Mohazabieh, Haniyeh Momeni-Asl, Maryam Yadegari, Aghdas Mirjalili, Morteza Anvari
BACKGROUND: The objective of the study was to investigate the protective effects of aqueous extract of Plantago ovata seed (AEPOS) on peptic ulcer induced by indomethacin (IND) in rats. METHODS: Rats (250-300 g) were divided into three groups (5 rats in each group). Gastric ulcer was induced by a single oral gavage of 48 mg/kg IND. The first group received only 5% sodium bicarbonate orally (5 ml/kg) whereas the control (IND) group received only single oral dose of 48 mg/kg IND...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29673261/medical-surgical-and-wound-care-management-of-ulcerated-infantile-hemangiomas-a-systematic-review
#4
Jane Y Wang, Arvin Ighani, Ana P Ayala, Sadanori Akita, Irene Lara-Corrales, Afsaneh Alavi
Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Seventy-seven studies met our inclusion criteria. One study was a randomized controlled trial, 30 were observational studies, and 46 were case reports or case series...
April 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29672874/review-article-novel-oral-targeted-therapies-in-inflammatory-bowel-disease
#5
REVIEW
J R White, F Phillips, T Monaghan, W Fateen, S Samuel, S Ghosh, G W Moran
BACKGROUND: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of medications that target specific genetic pathways found to be relevant in other immune mediated diseases. AIMS: To provide an overview of recent clinical trials for new generation oral targeted medications that may have a future role in IBD management...
April 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29672271/anti-ulcerogenic-effect-of-the-methanol-extract-of-chasmanthera-dependens-hochst-stem-on-male-wistar-rats
#6
Stephanie Abiola Tijani, Samuel B Olaleye, Ebenezer O Farombi
BACKGROUND: Oxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract of Chasmanthera dependens to protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats. METHODS: The C. dependens stems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h...
April 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29671544/recurrent-oral-ulcers-in-a-refugee
#7
Sahil Mullick, Yow-Jeng Franny Pan, Anand Desai, Sonal Singh, Essien Ekong
No abstract text is available yet for this article.
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29669068/adverse-reactions-after-intravenous-iron-infusion-among-inflammatory-bowel-disease-patients-in-the-united-states-2010-2014
#8
Eboselume Akhuemonkhan, Alyssa Parian, Kathryn A Carson, Susan Hutfless
Background: Anemia is a frequent complication of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD). Intravenous (IV) iron is recommended as the initial therapy for patients with clinically active IBD, severe anemia, and intolerance to oral iron. IV iron is associated with serious adverse effects including a black box warning for anaphylaxis with iron dextran and ferumoxytol. We aimed to examine the occurrence of adverse reactions including anaphylaxis after IV iron infusions in a large database of US IBD patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668982/improved-medical-treatment-and-surgical-surveillance-of-children-and-adolescents-with-ulcerative-colitis-in-the-united-kingdom
#9
Marcus Karl-Keinz Auth, Su K Bunn, Aimee Leanne Protheroe, Linda Jane Williams, John M Fell, Rafeeq Muhammed, Nicholas Michael Croft, R Mark Beattie, Anne Willmott, Christine Spray, Babu Vadamalayan, Astor Rodrigues, John Puntis, Anna Jane Pigott, David C Wilson, Sally Mitton, Mark Furman, Charlie Charlton, Sonny K F Chong, Richard K Russell
Background: Pediatric ulcerative colitis (UC) presents at an earlier age and increasing prevalence. Our aim was to examine morbidity, steroid sparing strategies, and surgical outcome in children with active UC. Methods: A national prospective audit was conducted for the inpatient period of all children with UC for medical or surgical treatment in the United Kingdom (UK) over 1 year. Thirty-two participating centers recruited 224 children in 298 admissions, comparisons over 6 years were made with previous audits...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668637/successful-mesenchymal-stem-cell-treatment-of-leg-ulcers-complicated-by-behcet-disease-a-case-report-and-literature-review
#10
Yanhong Li, Zhongming Wang, Yi Zhao, Yubin Luo, Wangdong Xu, Tony N Marion, Yi Liu
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667077/a-case-of-beh%C3%A3-et-s-disease-with-various-gastrointestinal-findings
#11
Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Shuji Terai
Behçet's disease (BD) is a systemic inflammatory disorder involving the oral and genital mucosa, skin, eyes, gastrointestinal tract, joints, vasculature, and nervous. The gastrointestinal lesions accompanying with BD can extend along the full length of the tract, from the mouth to the anus, and show various clinical characteristics which is difficult to be differentiate from the other inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Hence, the differential diagnosis is difficult and can affect treatment outcomes...
April 17, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29665355/combination-therapy-with-polydeoxyribonucleotide-and-proton-pump-inhibitor-enhances-therapeutic-effectiveness-for-gastric-ulcer-in-rats
#12
Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Chang-Ju Kim, Jin-Hee Han, In Taik Hong, Min Seop Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeon
AIMS: The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treatment can be enhanced. Thus, in order to improve the therapeutic effect on GU, we tried to develop combination therapy promoting regeneration in injured tissue besides suppressing gastric acid secretion. MAIN METHODS: Polydeoxyribonucleotide (PDRN) was selected to evaluate tissue regeneration, and pantoprazole was chosen as one of the PPIs...
April 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29663354/the-management-of-livedoid-vasculopathy-focused-on-direct-oral-anticoagulants-doacs-four-case-reports-successfully-treated-with-rivaroxaban
#13
Gabriela Franco Marques, Paulo Ricardo Criado, Thâmara Cristiane Alves Batista Morita, María Salomé Cajas García
Livedoid vasculopathy (LV) is a thrombotic skin disease characterized by episodic painful ulcerations of the distal aspects of the legs. Its healing process typically leaves small porcelain-white scars called atrophie blanche as a result of the occlusion of cutaneous microcirculation. The main goals of the treatment are pain management and the prevention of ulceration and of progressive scarring in the malleolar area. The therapeutic management is still a challenge, however, and most treatments were based on anecdotal off-label protocols...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29663036/systemic-administration-of-heparin-ameliorates-radiation-induced-oral-mucositis-preclinical-studies-in-mice
#14
Maria Kowaliuk, Eva Bozsaky, Sylvia Gruber, Peter Kuess, Wolfgang Dörr
PURPOSE: The present study investigates the impact of systemic application of heparins on the manifestation of radiation-induced oral mucositis in a well-established mouse model. MATERIALS AND METHODS: Male C3H/Neu mice were irradiated with either single-dose or fractionated irradiation protocols with 5 × 3 Gy/week, given over one (days 0-4) or two (days 0-4, 7-11) weeks. All fractionation protocols were concluded by a local test irradiation (day 7/14) using graded doses to generate complete dose-effect curves...
April 16, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#15
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
April 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29659758/accelerated-clearance-of-infliximab-is-associated-with-treatment-failure-in-patients-with-corticosteroid-refractory-acute-ulcerative-colitis
#16
David Kevans, Sanjay Murthy, Diane R Mould, Mark S Silverberg
Background and Aims: A significant proportion of patients with corticosteroid-refractory acute ulcerative colitis [UC] fail therapy. We aimed to assess the pharmacokinetics [PK] of infliximab [IFX] in patients with corticosteroid-refractory acute UC and determine the association between induction IFX PK and short- and long-term therapy outcome. Methods: A population PK model was developed using data from 51 patients with UC [n = 42] and Crohn's disease [n = 9]. A subset of patients [n = 36] with acute corticosteroid-refractory UC (median Mayo score 11 [range 8-12]; 33 of 36 hospitalized; median corticosteroid dose at study entry 50mg prednisolone equivalent IV/oral) commencing IFX were studied to assess further correlations between PK from the first induction dose and therapy outcomes...
April 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29659470/meta-analysis-of-perioperative-outcomes-of-acute-laparoscopic-vs-open-repair-of-perforated-gastroduodenal-ulcers
#17
Roberto Cirocchi, Kjetil Soreide, Salomone Di Saverio, Elena Rossi, Alberto Arezzo, Mauro Zago, Iosief Abraha, Nereo Vettoretto, Massimo Chiarugi
BACKGROUND: Surgery is the treatment of choice for perforated peptic ulcer disease (PUD). The aim of the present review is to compare the perioperative outcomes of acute laparoscopic versus open repair for PUD. METHODS: A systematic literature search was performed for randomized controlled trials (RCTs) published in PubMed, SCOPUS and Web of Science RESULTS: The search included eight RCTs: 615 patients comparing laparoscopic (307 patients) versus open peptic perforated ulcer repair (308 patients)...
April 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29657585/deterioration-in-saliva-quality-in-patients-with-sj%C3%A3-gren-s-syndrome-impact-of-decrease-in-salivary-epidermal-growth-factor-on-the-severity-of-intraoral-manifestations
#18
REVIEW
Naoto Azuma, Yoshinori Katada, Hajime Sano
Background: Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland dysfunction, most patients with SS have xerostomia related to a reduced salivary flow rate. In addition to the discomfort due to xerostomia, dry mouth can cause various intraoral manifestations such as refractory stomatitis, ulcer, and atrophic changes in the oral mucosa and tongue, and the patient's quality of life (QoL) is severely impaired...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29657421/expression-of-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-9-in-apis-mellifera-lawang-propolis-extract-gel-treated-traumatic-ulcers-in-diabetic-rats
#19
Diah Savitri Ernawati, Ade Puspa
Aim: The aim of this study was to determine the effect of Apis mellifera propolis extract gel on vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) expression in the traumatic ulcers of rats afflicted with diabetes mellitus (DM). Materials and Methods: The study was conducted on 24 male Wistar rats ( Rattus norvegicus ) induced with DM by injecting 50 mg/kg of Streptozotocin, intraperitoneally, and a traumatic ulcer on their lower lip mucosa...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29656541/a-novel-herpesvirus-associated-with-chronic-superficial-keratitis-and-proliferative-conjunctivitis-in-a-great-horned-owl-bubo-virginianus
#20
Molly D Gleeson, Bret A Moore, Sydney G Edwards, Sarah Stevens, April L Childress, James F X Wellehan, Jessica Robertson, Christopher J Murphy, Michelle G Hawkins, Joanne Paul-Murphy
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine...
April 14, 2018: Veterinary Ophthalmology
keyword
keyword
27429
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"