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https://www.readbyqxmd.com/read/28222488/explaining-counterfeit-alcohol-purchases-in-russia
#1
Zoya Kotelnikova
BACKGROUND: Alcohol is a common target of counterfeiting in Russia. Counterfeit alcohol is defined here as the manufacture, distribution, unauthorized placement (forgery) of protected commodity trademarks, and infringement of the exclusive rights of the registered trademark holders of alcoholic beverages. It is often argued that the expansion of the counterfeit product market is due to the steady demand of economically disadvantaged people for low-priced goods. The situation becomes more complicated once deceptive and nondeceptive forms of counterfeiting are taken into account...
February 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28220134/genome-wide-dissection-of-the-heat-shock-transcription-factor-family-genes-in-arachis
#2
Pengfei Wang, Hui Song, Changsheng Li, Pengcheng Li, Aiqin Li, Hongshan Guan, Lei Hou, Xingjun Wang
Heat shock transcription factors (Hsfs) are important transcription factors (TFs) in protecting plants from damages caused by various stresses. The released whole genome sequences of wild peanuts make it possible for genome-wide analysis of Hsfs in peanut. In this study, a total of 16 and 17 Hsf genes were identified from Arachis duranensis and A. ipaensis, respectively. We identified 16 orthologous Hsf gene pairs in both peanut species; however HsfXs was only identified from A. ipaensis. Orthologous pairs between two wild peanut species were highly syntenic...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28213307/enhanced-toxicity-to-the-cyanobacterium-microcystis-aeruginosa-by-low-dosage-repeated-exposure-to-the-allelochemical-n-phenyl-1-naphthylamine
#3
Y N Gao, F J Ge, L P Zhang, Y He, Z Y Lu, Y Y Zhang, B Y Liu, Q H Zhou, Z B Wu
It has been puzzling whether and how a plant could exert a strong allelopathic inhibition to the target organisms by releasing low concentrations of allelochemicals. Plant allelochemicals have been proposed to be released continuously, however, direct evidence from specific allelochemicals is urgently required. In the present study, the toxicity of allelochemical N-phenyl-1-naphthylamine (NPN) towards the cyanobacterium Microcystis aeruginosa by two different exposure patterns was compared. One was low-dosage repeated exposure (LRE), in which 50  μg L(-1) NPN was repeatedly dosed to simulate the continual release of allelochemicals, and the other one was high-dosage single exposure (HSE) as per the routine toxicity assay...
January 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28185061/a-regional-analysis-of-epidermal-growth-factor-receptor-egfr-mutated-lung-cancer-for-hse-south
#4
D Kelly, L Mc Sorley, E O'Shea, E Mc Carthy, S Bowe, C Brady, J Sui, M A Dawod, O O'Brien, D Graham, J McCarthy, L Burke, D Power, S O'Reilly, R M Bambury, D O Mahony
BACKGROUND: EGFR mutated lung cancer represents a subgroup with distinct clinical presentations, prognosis, and management requirements. We investigated the survival, prognostic factors, and real-world treatment of NSCLC patients with EGFR mutation in clinical practice. METHODS: A retrospective review of all specimens sent for EGFR analysis from December 2009 to September 2015 was performed. Patient demographics, specimen type, EGFR mutation status/type, stage at diagnosis, treatment, response rate, and survival data were recorded...
February 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28160519/systematic-study-of-the-effect-of-hse-functional-internal-parameters-on-the-electronic-structure-and-band-gap-of-a-representative-set-of-metal-oxides
#5
Francesc Viñes, Oriol Lamiel-García, Kyoung Chul Ko, Jin Yong Lee, Francesc Illas
The effect of the amount of Hartree-Fock mixing parameter (α) and of the screening parameter (w) defining the range separated HSE type hybrid functional is systematically studied for a series of seven metal oxides: TiO2 , ZrO2 , CuO2 , ZnO, MgO, SnO2 , and SrTiO3 . First, reliable band gap values were determined by comparing the optimal α reproducing the experiment with the inverse of the experimental dielectric constant. Then, the effect of the w in the HSE functional on the calculated band gap was explored in detail...
February 4, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28141863/measuring-high-sensitivity-cardiac-troponin-t-blood-concentration-in-population-surveys
#6
Antonio Ivan Lazzarino, Jennifer S Mindell
INTRODUCTION: The blood test for high-sensitivity cardiac troponin T (HS-CTnT) has been proposed as a marker of cardiovascular risk in the general population, as it is associated with subsequent incidence of cardiovascular events and mortality. We aimed at evaluating the feasibility of HS-CTnT testing within large nationally-representative population surveys in which blood samples are collected during household visits, shipped using the standard civil postal service, and then frozen for subsequent analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28141834/assessment-of-non-response-bias-in-estimates-of-alcohol-consumption-applying-the-continuum-of-resistance-model-in-a-general-population-survey-in-england
#7
Sadie Boniface, Shaun Scholes, Nicola Shelton, Jennie Connor
BACKGROUND: Previous studies have shown heavier drinkers are less likely to respond to surveys and require extended efforts to recruit. This study applies the continuum of resistance model to explore how survey estimates of alcohol consumption may be affected by non-response bias in three consecutive years of a general population survey in England. METHODS: Using the Health Survey for England (HSE) survey years 2011-13, number of contact attempts (1-6 and 7+) were explored by socio-demographic and drinking characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28129328/chlamydia-trachomatis-pgp3-antibody-population-seroprevalence-before-and-during-an-era-of-widespread-opportunistic-chlamydia-screening-in-england-1994-2012
#8
Sarah C Woodhall, Gillian S Wills, Patrick J Horner, Rachel Craig, Jennifer S Mindell, Gary Murphy, Myra O McClure, Kate Soldan, Anthony Nardone, Anne M Johnson
BACKGROUND: Opportunistic chlamydia screening of <25 year-olds was nationally-implemented in England in 2008 but its impact on chlamydia transmission is poorly understood. We undertook a population-based seroprevalence study to explore the impact of screening on cumulative incidence of chlamydia, as measured by C.trachomatis-specific antibody. METHODS: Anonymised sera from participants in the nationally-representative Health Surveys for England (HSE) were tested for C...
2017: PloS One
https://www.readbyqxmd.com/read/28122479/photoprotection-by-pistachio-bioactives-in-a-3-dimensional-human-skin-equivalent-tissue-model
#9
C-Y Oliver Chen, Avi Smith, Yuntao Liu, Peng Du, Jeffrey B Blumberg, Jonathan Garlick
Reactive oxygen species (ROS) generated during ultraviolet (UV) light exposure can induce skin damage and aging. Antioxidants can provide protection against oxidative injury to skin via "quenching" ROS. Using a validated 3-dimensional (3D) human skin equivalent (HSE) tissue model that closely mimics human skin, we examined whether pistachio antioxidants could protect HSE against UVA-induced damage. Lutein and γ-tocopherol are the predominant lipophilic antioxidants in pistachios; treatment with these compounds prior to UVA exposure protected against morphological changes to the epithelial and connective tissue compartments of HSE...
January 25, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28116674/enhanced-viral-clearance-and-reduced-leukocyte-infiltration-in-experimental-herpes-encephalitis-after-intranasal-infection-of-cxcr3-deficient-mice
#10
J Zimmermann, W Hafezi, A Dockhorn, Eva U Lorentzen, M Krauthausen, Daniel R Getts, M Müller, Joachim E Kühn, Nicholas J C King
Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common fatal sporadic encephalitis in developed countries. There is evidence from HSE animal models that not only direct virus-mediated damage caused but also the host's immune response contributes to the high mortality of the disease. Chemokines modulate and orchestrate this immune response. Previous experimental studies in HSE models identified the chemokine receptor CXCR3 and its ligands as molecules with a high impact on the course of HSE in mouse models...
January 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28109219/the-role-of-the-van-der-waals-interactions-in-the-adsorption-of-anthracene-and-pentacene-on-the-ag-111-surface
#11
Juliana M Morbec, Peter Kratzer
Using first-principles calculations based on density-functional theory (DFT), we investigated the effects of the van der Waals (vdW) interactions on the structural and electronic properties of anthracene and pentacene adsorbed on the Ag(111) surface. We found that the inclusion of vdW corrections strongly affects the binding of both anthracene/Ag(111) and pentacene/Ag(111), yielding adsorption heights and energies more consistent with the experimental results than standard DFT calculations with generalized gradient approximation (GGA)...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28097679/abnormal-levels-of-seven-amino-neurotransmitters-in-depression-rat-brain-and-determination-by-hplc-fld
#12
Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jiang
The determination of amino acids with the actions-like neurotransmitters or modulators have been increasingly important for diagnose in many neuropsychiatric diseases. A rapid and simple high performance liquid chromatography with fluorescence detection (HPLC-FLD) was developed for simultaneous determination of seven amino acids: aspartate (Asp), glutamate (Glu), serine (Ser), glutamine (Gln), glycine (Gly), taurine (Tau) and γ-aminobutyric acid (GABA). Homoserine (Hse) was used as an internal standard (IS)...
January 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28090058/herpes-simplex-encephalitis-complicated-by-cerebral-hemorrhage-during-acyclovir-therapy
#13
Yukinori Harada, Yuuta Hara
Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28074766/-herpes-simplex-encephalitis
#14
Laura Krogh Jørgensen, Trine Hyrup Mogensen
Herpes simplex encephalitis (HSE) is a rare disease, although it is the most common form of sporadic encephalitis worldwide. Recently, studies have provided important new insight into the genetic and immunological basis of HSE. However, even in the presence of antiviral treatment, mortality and morbidity remain relatively high. Therefore, precise and early diagnosis together with basic and clinical studies to gain better insight into the pathogenesis of HSE is a prerequisite for the development of improved prophylaxis and treatment of this severe disease...
January 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28058442/%C3%AF-phosphorene-a-new-allotrope-of-phosphorene
#15
Haidi Wang, Xingxing Li, Zhao Liu, Jinlong Yang
Based on the crystal structure prediction, we propose a new allotrope of phosphorene, ψ-phosphorene (ψ-P), with a porous structure, which is both thermally and dynamically stable in comparison with the previously reported allotropes. Due to its unique atom configuration, ψ-P has highly orientation-dependent mechanical properties and excellent flexibility. Calculations using the HSE functional predict that ψ-P is semiconducting with an indirect band gap of 1.57 eV and possesses anisotropic transport properties...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28051827/job-stress-an-in-depth-investigation-based-on-the-hse-questionnaire-and-a-multistep-approach-in-order-to-identify-the-most-appropriate-corrective-actions
#16
S De Sio, F Cedrone, E Greco, M Di Traglia, D Sanità, D Mandolesi, S A Stansfeld
BACKGROUND: Psychosocial hazards and work-related stress have reached epidemic proportions in Europe. The Italia law introduced in 2008 the obligation for Italian companies to assess work related stress risk in order to protect their workers' safety and health. The purpose of our study was to propose an accurate measurement tool, using the HSE indicator tool, for more appropriate and significant work-related stress' prevention measures. METHODS: The study was conducted on 204 visual display unit (VDU) operators: 106 male and 98 female...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28045701/unexpected-heat-shock-element-binding-ability-and-tumor-killing-activity-of-the-combinatorial-function-domain-of-apoptin
#17
Liqiu Zhang, Jia Yang, Lu Liu, Wei Tian, Ming Gao, Weiwei Song, Hong Ling, Xingli Dong
Apoptin, derived from the chicken anemia virus, has been found to exert tumor-preferential apoptotic activity. It is a potential anticancer agent with direct clinical applications. However, if this viral protein were to be used as a new drug, it might also induce a strong immune response, causing toxic side effects. In a previous study, our group showed that TAT-apoptin downregulates the stress expression of heat shock protein 70 by competing with heat shock factor protein 1 in binding to the heat shock element (HSE) of the promoter region of heat shock protein 70, thus inducing specific apoptosis in HepG2 cells...
December 29, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28035614/health-safety-and-environmental-unit-performance-assessment-model-under-uncertainty-case-study-steel-industry
#18
Azin Shamaii, Manouchehr Omidvari, Farhad Hosseinzadeh Lotfi
Performance assessment is a critical objective of management systems. As a result of the non-deterministic and qualitative nature of performance indicators, assessments are likely to be influenced by evaluators' personal judgments. Furthermore, in developing countries, performance assessments by the Health, Safety and Environment (HSE) department are based solely on the number of accidents. A questionnaire is used to conduct the study in one of the largest steel production companies in Iran. With respect to health, safety, and environment, the results revealed that control of disease, fire hazards, and air pollution are of paramount importance, with coefficients of 0...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28028793/in-vitro-drug-transfer-due-to-drug-retention-in-human-epidermis-pretreated-with-application-of-marketed-estradiol-transdermal-systems
#19
Yellela S R Krishnaiah, Naresh Pavurala, Yang Yang, Prashanth Manda, Usha Katragadda, Yongsheng Yang, Rakhi Shah, Guodong Fang, Mansoor A Khan
Study objective was to assess skin-to-skin drug transfer potential that may occur due to drug retention in human epidermis (DRE) pretreated with application of estradiol transdermal drug delivery systems (TDDS) and other estradiol transdermal dosage forms (gels and sprays). TDDS (products-A, B, and C) with varying formulation design and composition, and other estradiol transdermal products (gel and spray) were applied to heat separated human epidermis (HSE) and subjected to in vitro drug permeation study. Amounts of DRE were quantified after 24 h...
December 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27930721/both-cerebral-and-hematopoietic-deficiencies-in-ccr2-result-in-uncontrolled-herpes-simplex-virus-infection-of-the-central-nervous-system-in-mice
#20
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress from the bone marrow (BM) and their trafficking into the central nervous system (CNS) in several neurological diseases. During experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE), CCR2 deficiency has been reported to exacerbate the outcome of the disease...
2016: PloS One
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