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https://www.readbyqxmd.com/read/28415709/a-peptide-derived-from-apoptin-inhibits-glioma-growth
#1
Liqiu Zhang, Hengyu Zhao, Zhongqi Cui, Yueshan Lv, Wenjia Zhang, Xiaoyu Ma, Jianan Zhang, Banghao Sun, Danyang Zhou, Lijie Yuan
Glioblastoma (GBM) is associated with poor prognosis due to its resistance to surgery, irradiation, and conventional chemotherapy. Thus, efficient therapeutic approaches for the treatment of GBM are urgently needed. HSP70 is an antiapoptotic protein that participates in the inhibition of both mitochondrial and membrane receptor apoptosis pathways and is highly expressed in glioma tissues. Here, we investigated a derivative of apoptin; specifically, a chicken anemia viral protein with selective toxicity toward cancer cells that can inhibit hyperactive molecules, including HSP70...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28368532/tlr3-mutations-in-adult-patients-with-herpes-simplex-virus-and-varicella-zoster-virus-encephalitis
#2
Manuela Sironi, Anna Maria Peri, Rachele Cagliani, Diego Forni, Stefania Riva, Mara Biasin, Mario Clerici, Andrea Gori
Defects in genes of the TLR3 pathway are associated with susceptibility to HSV-1 encephalitis (HSE). We analyzed a cohort of 11 adult Italian patients who developed viral encephalitis. We detected two rare missense mutations in TLR3: one in a HSE patient (p.Leu297Val ) and the other in an individual with VZV encephalitis (p.Leu199Phe). Both mutations are extremely rare in human populations and have pathogenicity scores highly suggestive of a functional effect. Data herein expand the phenotypic spectrum of TLR3 mutations to VZV encephalitis and support the role of TLR3 genetic defects as risk factors for herpesvirus encephalitis in adults...
March 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28364664/contribution-of-neuroinflammation-to-changes-in-11-c-flumazenil-binding-in-the-rat-brain-evaluation-of-the-inflamed-pons-as-reference-tissue
#3
Andrea Parente, David Vállez García, Alexandre Shoji, Isadora Lopes Alves, Bram Maas, Rolf Zijlma, Rudi Ajo Dierckx, Carlos A Buchpiguel, Erik Fj de Vries, Janine Doorduin
INTRODUCTION: [(11)C]Flumazenil is a well-known PET tracer for GABAA receptors and is mainly used as an imaging biomarker for neuronal loss. Recently, GABAA receptors on immune cells have been investigated as target for modulation of inflammation. Since neuronal loss is often accompanied by neuroinflammation, PET imaging with [(11)C]flumazenil is potentially affected by infiltrating immune cells. This may also compromise the validity of using the pons as reference tissue in quantitative pharmacokinetic analysis...
March 18, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28355421/an-assessment-of-the-robustness-of-the-coshh-essentials-c-e-target-airborne-concentration-ranges-15-years-on-and-their-usefulness-for-determining-control-measures
#4
Nicholas P Vaughan, Rajadurai Rajan-Sithamparanadarajah
The Health and Safety Executive (HSE) in Great Britain (GB), in association with its stakeholders, developed the Control of Substances Hazardous to Health (COSHH)-Essentials (C-E) control banding tool in 1998. The objective was to provide a simple tool for employers, particularly small and medium-sized enterprises (SMEs), to help select and apply appropriate measures for the adequate control of exposure to hazardous substances. The tool used hazard classification information (R-phrases) to assign substances to one of five health hazard groups, each with its respective 'target airborne concentration range'...
February 21, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28345727/intrinsic-defects-and-their-effects-on-the-optical-properties-in-the-nonlinear-optical-crystal-cdsip2-a-first-principles-study
#5
Ci Wang, Jie Sun, Huiyang Gou, Shanpeng Wang, Jian Zhang, Xutang Tao
In view of their high nonlinear optical coefficients and good phase-matching properties, CdSiP2 (CSP) crystals are considered as one of the most promising materials in the field of nonlinear optical applications. However, the slight absorption losses around 1.34 μm and 1.78 μm under e-polarized light have been affecting its performance. In this study, first-principles calculations were performed to identify the effects of various charge defects on the absorption properties. Different intrinsic defects in the CSP crystal were calculated using the HSE method and compared according to the specific chemical environments in the experiments...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28331120/color-functionality-used-in-visual-display-for-occupational-and-environmental-safety-and-managing-color-vision-deficiency
#6
Nobuhisa Ochiai, Hiroyuki Kondo
The effects of color perception are utilized in visual displays for the purpose of safety in the workplace and in daily life. These effects, generally known as color functionality, are divided into four classifications: visibility, legibility, conspicuity and discriminability. This article focuses on the relationship between the color functionality of color schemes used in visual displays for occupational and environmental safety and color vision deficiency (particularly congenital red-green color deficiency), a critical issue in ophthalmology, and examines the effects of color functionality on the perception of the color red in individuals with protan defects...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28302316/defining-nervous-system-susceptibility-during-acute-and-latent-herpes-simplex-virus-1-infection
#7
REVIEW
Chandra M Menendez, Daniel J J Carr
Herpes simplex viruses are neurotropic human pathogens that infect and establish latency in peripheral sensory neurons of the host. Herpes Simplex Virus-1 (HSV-1) readily infects the facial mucosa that can result in the establishment of a latent infection in the sensory neurons of the trigeminal ganglia (TG). From latency, HSV-1 can reactivate and cause peripheral pathology following anterograde trafficking from sensory neurons. Under rare circumstances, HSV-1 can migrate into the central nervous system (CNS) and cause Herpes Simplex Encephalitis (HSE), a devastating disease of the CNS...
March 8, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28295305/mitochondrial-ros-induced-erk1-2-activation-and-hsf2-mediated-at1-r-upregulation-are-required-for-doxorubicin-induced-cardiotoxicity
#8
Chih-Yang Huang, Jia-Yi Chen, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho, Tung-Sheng Chen, Fu-Jen Tsai, V Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huang
Doxorubicin (DOX), one useful chemotherapeutic agent, is limited in clinical use because of its serious cardiotoxicity. Growing evidence suggests that angiotensin receptor blockers (ARBs) have cardioprotective effects in DOX-induced cardiomyopathy. However, the detailed mechanisms underlying the action of ARBs on the prevention of DOX-induced cardiomyocyte cell death have yet to be investigated. Our results showed that angiotensin II receptor type I (AT1 R) plays a critical role in DOX-induced cardiomyocyte apoptosis...
March 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28285253/effect-of-self-esteem-on-social-interactions-during-the-ultimatum-game
#9
V Paz, E Nicolaisen-Sobesky, E Collado, S Horta, C Rey, M Rivero, P Berriolo, M Díaz, M Otón, A Pérez, G Fernández-Theoduloz, Á Cabana, V B Gradin
Self-esteem is an attitude formed by self-evaluation based on positive and negative aspects of oneself. Low self-esteem is a risk factor for psychiatric disorders and is especially associated with social difficulties. Recently, behavioral economics has allowed the quantitative study of social interactions. We investigated the association between self-esteem and interpersonal problems and whether self-esteem modulates behavior and emotions during an economic task, the Ultimatum Game (UG). In this task participants accept or reject fair/unfair monetary offers from others...
March 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28278385/the-type-i-interferon-response-and-age-dependent-susceptibility-to-herpes-simplex-virus-infection
#10
Daniel Giraldo, Douglas R Wilcox, Richard Longnecker
Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection...
March 9, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28261514/psychosis-in-a-15-year-old-female-with-herpes-simplex-encephalitis-in-a-background-of-mannose-binding-lecithin-deficiency
#11
Kenneth Asogwa, Kwame Buabeng, Amarjit Kaur
Historically, psychotic disorder has been associated with viral infection. Herpes simplex infections and Epstein-Barr virus (EBV) among other viral infections have been implicated in psychotic disorder. Of note in this case report is psychotic disorder that occurred following reactivation of herpes simplex infection in a background of mannose-binding lecithin (MBL) deficiency, childhood EBV infection, and severe psychosocial stress. Herpes simplex encephalitis (HSE) remains a significant cause of morbidity and mortality despite advancement in its treatment with intravenous acyclovir...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28256928/performance-assessment-of-human-resource-by-integration-of-hse-and-ergonomics-and-efqm-management-system
#12
Mohsen Sadegh Amalnick, Mansour Zarrin
Purpose The purpose of this paper is to present an integrated framework for performance evaluation and analysis of human resource (HR) with respect to the factors of health, safety, environment and ergonomics (HSEE) management system, and also the criteria of European federation for quality management (EFQM) as one of the well-known business excellence models. Design/methodology/approach In this study, an intelligent algorithm based on adaptive neuro-fuzzy inference system (ANFIS) along with fuzzy data envelopment analysis (FDEA) are developed and employed to assess the performance of the company...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28253843/cancer-related-health-behaviours-of-young-people-not-in-education-employment-or-training-neet-a-cross-sectional-study
#13
Catherine H Stewart, Philip Berry, Dunja Przulj, Charlene Treanor
BACKGROUND: Links between participating in unhealthy behaviours, e.g. smoking, and an increased risk of developing some cancers are well established. Unemployed adults are more likely to participate in cancer-related health behaviours than their employed counterparts. However, evidence of whether this is true in young adults not in education, employment or training (NEET) compared to their 'non-NEET' peers is either limited or inconclusive. Using cross-sectional health data from across the UK, this study aims to investigate whether participation in cancer-related health behaviours varies by NEET status...
March 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28251511/herpes-simplex-encephalitis-an-update
#14
REVIEW
John W Gnann, Richard J Whitley
PURPOSE OF REVIEW: The goal of this review is to provide an update on current thinking regarding herpes simplex encephalitis (HSE), emphasizing new information about pathogenesis, diagnosis, and immune responses. Specific questions to be addressed are the following: (1) Is there a genetic predisposition to HSE? (2) What clinical approaches have the greatest impact on improving the long-term outcomes in patients with HSE? And (3) are there immune-mediated mechanisms that may account for relapsing HSE? RECENT FINDINGS: Toll-like receptor 3 (TLR 3) plays an important role in innate immune responses, including generation of interferons...
March 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28244581/work-related-stress-and-blood-glucose-levels
#15
A Sancini, S Ricci, F Tomei, C Sacco, A Pacchiarotti, N Nardone, P Ricci, A Suppi, D P De Cesare, V Anzelmo, R Giubilati, B Pimpinella, M V Rosati, G Tomei
AIM: The aim of the study is to evaluate work-related subjective stress in a group of workers on a major Italian company in the field of healthcare through the administration of a valid "questionnaire-tool indicator" (HSE Indicator Tool), and to analyze any correlation between stress levels taken from questionnaire scores and blood glucose values. MATERIAL AND METHODS: We studied a final sample consisting of 241 subjects with different tasks. The HSE questionnaire - made up of 35 items (divided into 7 organizational dimensions) with 5 possible answers - has been distributed to all the subjects in occasion of the health surveillance examinations provided by law...
March 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28222488/explaining-counterfeit-alcohol-purchases-in-russia
#16
Zoya Kotelnikova
BACKGROUND: Alcohol is a common target of counterfeiting in Russia. Counterfeit alcohol is defined here as the manufacture, distribution, unauthorized placement (forgery) of protected commodity trademarks, and infringement of the exclusive rights of the registered trademark holders of alcoholic beverages. It is often argued that the expansion of the counterfeit product market is due to the steady demand of economically disadvantaged people for low-priced goods. The situation becomes more complicated once deceptive and nondeceptive forms of counterfeiting are taken into account...
April 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28220134/genome-wide-dissection-of-the-heat-shock-transcription-factor-family-genes-in-arachis
#17
Pengfei Wang, Hui Song, Changsheng Li, Pengcheng Li, Aiqin Li, Hongshan Guan, Lei Hou, Xingjun Wang
Heat shock transcription factors (Hsfs) are important transcription factors (TFs) in protecting plants from damages caused by various stresses. The released whole genome sequences of wild peanuts make it possible for genome-wide analysis of Hsfs in peanut. In this study, a total of 16 and 17 Hsf genes were identified from Arachis duranensis and A. ipaensis, respectively. We identified 16 orthologous Hsf gene pairs in both peanut species; however HsfXs was only identified from A. ipaensis. Orthologous pairs between two wild peanut species were highly syntenic...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28213307/enhanced-toxicity-to-the-cyanobacterium-microcystis-aeruginosa-by-low-dosage-repeated-exposure-to-the-allelochemical-n-phenyl-1-naphthylamine
#18
Y N Gao, F J Ge, L P Zhang, Y He, Z Y Lu, Y Y Zhang, B Y Liu, Q H Zhou, Z B Wu
It has been puzzling whether and how a plant could exert a strong allelopathic inhibition to the target organisms by releasing low concentrations of allelochemicals. Plant allelochemicals have been proposed to be released continuously, however, direct evidence from specific allelochemicals is urgently required. In the present study, the toxicity of allelochemical N-phenyl-1-naphthylamine (NPN) towards the cyanobacterium Microcystis aeruginosa by two different exposure patterns was compared. One was low-dosage repeated exposure (LRE), in which 50  μg L(-1) NPN was repeatedly dosed to simulate the continual release of allelochemicals, and the other one was high-dosage single exposure (HSE) as per the routine toxicity assay...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28185061/a-regional-analysis-of-epidermal-growth-factor-receptor-egfr-mutated-lung-cancer-for-hse-south
#19
D Kelly, L Mc Sorley, E O'Shea, E Mc Carthy, S Bowe, C Brady, J Sui, M A Dawod, O O'Brien, D Graham, J McCarthy, L Burke, D Power, S O'Reilly, R M Bambury, D O Mahony
BACKGROUND: EGFR mutated lung cancer represents a subgroup with distinct clinical presentations, prognosis, and management requirements. We investigated the survival, prognostic factors, and real-world treatment of NSCLC patients with EGFR mutation in clinical practice. METHODS: A retrospective review of all specimens sent for EGFR analysis from December 2009 to September 2015 was performed. Patient demographics, specimen type, EGFR mutation status/type, stage at diagnosis, treatment, response rate, and survival data were recorded...
February 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28160519/systematic-study-of-the-effect-of-hse-functional-internal-parameters-on-the-electronic-structure-and-band-gap-of-a-representative-set-of-metal-oxides
#20
Francesc Viñes, Oriol Lamiel-García, Kyoung Chul Ko, Jin Yong Lee, Francesc Illas
The effect of the amount of Hartree-Fock mixing parameter (α) and of the screening parameter (w) defining the range separated HSE type hybrid functional is systematically studied for a series of seven metal oxides: TiO2 , ZrO2 , CuO2 , ZnO, MgO, SnO2 , and SrTiO3 . First, reliable band gap values were determined by comparing the optimal α reproducing the experiment with the inverse of the experimental dielectric constant. Then, the effect of the w in the HSE functional on the calculated band gap was explored in detail...
February 4, 2017: Journal of Computational Chemistry
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