keyword
MENU ▼
Read by QxMD icon Read
search

Hse

keyword
https://www.readbyqxmd.com/read/29900087/fulminant-herpes-simplex-virus-type-i-encephalitis-despite-maximal-medical-therapy
#1
Nakul Katyal, Ather M Taqui, Deborah Tepper, Jonathan M Beary, Christopher R Newey
Herpes simplex-1 virus encephalitis (HSE) is the most commonly recognized cause of sporadic encephalitis in the United States. Historically HSE has been considered extremely detrimental given the associated relentless neurological deterioration secondary to cerebral edema and status epilepticus. With recent advances in antiviral therapeutics in past decades, the majority of complications can be managed effectively although the associated morbidity and mortality still remains high. The key modifiable factor determining recovery is the rapid initiation of antiviral therapy...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29859685/enantioselective-multiple-heartcut-two-dimensional-ultra-high-performance-liquid-chromatography-method-with-a-coreshell-chiral-stationary-phase-in-the-second-dimension-for-analysis-of-all-proteinogenic-amino-acids-in-a-single-run
#2
Ulrich Woiwode, Stefan Neubauer, Wolfgang Lindner, Stephan Buckenmaier, Michael Lämmerhofer
A multiple heartcut (MHC) 2D-UHPLC method with UV detection has been developed for the enantioselective analysis of complex amino acid mixtures in a single run. The MHC method is based on an achiral gradient RPLC separation with 1.8 μm C18 phase (100 × 2.1 mm ID column) in the first dimension (1 D) and enantioselective isocratic separation on a tert-butylcarbamoylquinine-based 2.7 μm Coreshell particle column (50 × 3 mm ID) in the second dimension (2 D). Pre-column derivatization has been performed with Sanger's reagent (2,4-dinitrofluorobenzene) yielding chromogenic 2,4-dinitrophenylated amino acids (DNP-AAs)...
May 28, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29848849/acyclovir-sensitivity-and-neurovirulence-of-herpes-simplex-virus-type-1-with-amino-acid-substitutions-in-the-viral-thymidine-kinase-gene-which-were-detected-in-the-patients-with-intractable-herpes-simplex-encephalitis-previously-reported
#3
Takuya Inagaki, Masaaki Satoh, Hikaru Fujii, Souichi Yamada, Miho Shibamura, Tomoki Yoshikawa, Shizuko Harada, Haruko Takeyama, Masayuki Saijo
Several cases of herpes simplex encephalitis (HSE) caused by acyclovir (ACV)-resistant herpes simplex virus type 1 (HSV-1) have been reported. Amino acid substitutions of R41H, Q125H, and A156V in the viral thymidine kinase (vTK) gene were reported to confer ACV-resistance. Recombinant HSV-1 clones with each amino acid substitution in the vTK were generated using the bacterial artificial chromosome (BAC) system. A recombinant HSV-1 with the substitution of Q125H showed ACV-resistance, while those of R41H or A156V were sensitive to ACV...
May 31, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29790095/full-thickness-human-skin-equivalent-models-of-atopic-dermatitis
#4
Gopu Sriram, Paul Lorenz Bigliardi, Mei Bigliardi-Qi
Atopic dermatitis is a chronic inflammatory skin disease caused by complex multifactorial etiology. In the recent years, there have been significant advances in tissue engineering and the generation of in vitro skin models representative of healthy and diseased states. This chapter describes the methodology for the fabrication of in vitro human skin equivalent (HSE) from human keratinocytes and fibroblasts using a fibrin-based dermal matrix and serum-free culture conditions. Modification of the culture conditions with the supplementation of Th2 cytokines such as interleukin-4 induces the development of atopic dermatitis-like skin model...
May 23, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29744305/evaluating-the-relationship-between-job-stress-and-job-satisfaction-among-female-hospital-nurses-in-babol-an-application-of-structural-equation-modeling
#5
Majid Bagheri Hosseinabadi, Siavash Etemadinezhad, Narges Khanjani, Omran Ahmadi, Hemat Gholinia, Mina Galeshi, Seyed Ehsan Samaei
Background: This study was designed to investigate job satisfaction and its relation to perceived job stress among hospital nurses in Babol County, Iran. Methods: This cross-sectional study was conducted on 406 female nurses in 6 Babol hospitals. Respondents completed the Minnesota Satisfaction Questionnaire (MSQ), the health and safety executive (HSE) indicator tool and a demographic questionnaire. Descriptive, analytical and structural equation modeling (SEM) analyses were carried out applying SPSS v. 22 and AMOS v...
2018: Health Promotion Perspectives
https://www.readbyqxmd.com/read/29741583/lzw-kernel-fast-kernel-utilizing-variable-length-code-blocks-from-lzw-compressors-for-protein-sequence-classification
#6
Gleb Filatov, Bruno Bauwens, Attila Kertész-Farkas
Motivation: Bioinformatics studies often rely on similarity measures between sequence pairs, which often pose a bottleneck in large-scale sequence analysis. Results: Here, we present a new convolutional kernel function for protein sequences called the LZW-Kernel. It is based on code words identified with the Lempel-Ziv-Welch (LZW) universal text compressor. The LZW-Kernel is an alignment-free method, it is always symmetric, is positive, always provides 1.0 for self-similarity and it can directly be used with Support Vector Machines (SVMs) in classification problems, contrary to normalized compression distance (NCD), which often violates the distance metric properties in practice and requires further techniques to be used with SVMs...
May 7, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29733381/the-longevity-snp-rs2802292-uncovered-hsf1-activates-stress-dependent-expression-of-foxo3-through-an-intronic-enhancer
#7
Valentina Grossi, Giovanna Forte, Paola Sanese, Alessia Peserico, Tugsan Tezil, Martina Lepore Signorile, Candida Fasano, Rosaura Lovaglio, Rosanna Bagnulo, Daria C Loconte, Francesco C Susca, Nicoletta Resta, Cristiano Simone
The HSF and FOXO families of transcription factors play evolutionarily conserved roles in stress resistance and lifespan. In humans, the rs2802292 G-allele at FOXO3 locus has been associated with longevity in all human populations tested; moreover, its copy number correlated with reduced frequency of age-related diseases in centenarians. At the molecular level, the intronic rs2802292 G-allele correlated with increased expression of FOXO3, suggesting that FOXO3 intron 2 may represent a regulatory region. Here we show that the 90-bp sequence around the intronic single nucleotide polymorphism rs2802292 has enhancer functions, and that the rs2802292 G-allele creates a novel HSE binding site for HSF1, which induces FOXO3 expression in response to diverse stress stimuli...
May 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29730051/multimodal-management-of-severe-herpes-simplex-virus-encephalitis-a-case-report-and-literature-review
#8
REVIEW
J Todeschi, A Gubian, T Wirth, H-A Coca, F Proust, H Cebula
BACKGROUND: Herpes simplex encephalitis (HSE) is the most frequent sporadic encephalitis in the world. In severe cases of HSE, the pathology usually progresses with an increase in intracranial pressure secondary to cerebral edema and/or hemorrhagic necrosis. Currently no high-power studies exist regarding the management of severe HSE and most of the papers reported in the literature are case reports. Decompressive craniectomy, effective in some cases of pharmaco-resistant intracranial hypertension (ICH) resulting from other causes, may be suggested in severe HSE, with several good results reported in the literature...
May 2, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29719649/a-case-of-post-encephalitic-optic-neuritis-clinical-spectrum-differential-diagnosis-and-management
#9
Ravinder Kumar, Abhishek Bhargava, Gagan Jaiswal, Viral R Soni, Bhoomika Katbamna, Arpit Vashisht
Purpose: Most cases of optic neuritis are idiopathic or are associated with multiple sclerosis. We present a case in which a young female developed post-infectious left optic neuritis following herpes simplex encephalitis (HSE). Case Report: A 24-year-old female presented with a severe headache, fever, and malaise of a one-week duration. Viral encephalitis was diagnosed and treated; intravenous acyclovir (750 mg every 8 h) was administered for 14 days. The patient improved clinically and was prescribed oral valacyclovir (1,000 mg, three times daily) for an additional 3 months as an outpatient...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29709325/3d-biomaterial-matrix-to-support-long-term-full-thickness-immuno-competent-human-skin-equivalents-with-nervous-system-components
#10
Sarah E Lightfoot Vidal, Kasey A Tamamoto, Hanh Nguyen, Rosalyn D Abbott, Dana M Cairns, David L Kaplan
Current commercially available human skin equivalents (HSEs) are used for relatively short term studies (∼1 week) due in part to the time-dependent contraction of the collagen gel-based matrix and the limited cell types and skin tissue components utilized. In contrast, here we describe a new matrix consisting of a silk-collagen composite system that provides long term, stable cultivation with reduced contraction and degradation over time. This matrix supports full thickness skin equivalents which include nerves...
April 24, 2018: Biomaterials
https://www.readbyqxmd.com/read/29698873/clinical-significance-of-igm-and-iga-class-anti-nmdar-antibodies-in-herpes-simplex-encephalitis
#11
Gabriel Westman, Azita Sohrabian, Elisabeth Aurelius, Clas Ahlm, Silvia Schliamser, Fredrik Sund, Marie Studahl, Johan Rönnelid
BACKGROUND: Herpes simplex encephalitis (HSE) is a devastating disease, often leaving patients with severe disabilities. It has been shown that IgG anti-N-methyl-d-aspartate receptor (NMDAR) antibodies appear in approximately 25% of HSE patients and could be associated with impaired recovery of cognitive performance. OBJECTIVES: To characterize the prevalence of IgM and IgA anti-NMDAR antibodies in HSE patients, in relation to subsequent development of IgG anti-NMDAR and correlation to cognitive performance...
June 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29665468/validation-of-haplotype-specific-extraction-for-separating-a-mitochondrial-dna-model-mixture-and-application-to-simulated-casework
#12
Judith Zander, Petra Otremba, Marion Nagy
Haplotype-specific extraction (HSE) is a new field of application for the separation of mitochondrial DNA (mtDNA) mixtures and is developed to identify the mtDNA haplotypes of the contributors subsequently by sequencing. Here we show the validation of HSE with an exemplary mitochondrial DNA mixture into its individual haplotypes according to our laboratory standards. These specify several critical areas of assay performance to be tested, such as sensitivity, robustness and mixture studies comprising varying proportions of their components,degraded samples and samples of different qualities and material...
July 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29661622/rational-design-and-screening-of-peptide-based-inhibitors-of-heat-shock-factor-1-hsf1
#13
Xu Ran, Eileen T Burchfiel, Bushu Dong, Nicholas J Rettko, Bryan M Dunyak, Hao Shao, Dennis J Thiele, Jason E Gestwicki
Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that regulates expression of protein chaperones and cell survival factors. In cancer, HSF1 plays a unique role, hijacking the normal stress response to drive a cancer-specific transcriptional program. These observations suggest that HSF1 inhibitors could be promising therapeutics. However, HSF1 is activated through a complex mechanism, which involves release of a negative regulatory domain, leucine zipper 4 (LZ4), from a masked oligomerization domain (LZ1-3), and subsequent binding of the oligomer to heat shock elements (HSEs) in HSF1-responsive genes...
April 7, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29561175/diurnal-effects-of-prior-heat-stress-exposure-on-sprint-and-endurance-exercise-capacity-in-the-heat
#14
Hidenori Otani, Mitsuharu Kaya, Akira Tamaki, Heita Goto, Takayuki Goto, Minayuki Shirato
Active individuals often perform exercises in the heat following heat stress exposure (HSE) regardless of the time-of-day and its variation in body temperature. However, there is no information concerning the diurnal effects of a rise in body temperature after HSE on subsequent exercise performance in a hot environnment. This study therefore investigated the diurnal effects of prior HSE on both sprint and endurance exercise capacity in the heat. Eight male volunteers completed four trials which included sprint and endurance cycling tests at 30 °C and 50% relative humidity...
March 21, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29544934/stress-induced-protein-s-glutathionylation-and-phosphorylation-crosstalk-in-cardiac-sarcomeric-proteins-impact-on-heart-function
#15
Nourdine Chakouri, Cyril Reboul, Doria Boulghobra, Adrien Kleindienst, Stéphane Nottin, Sandrine Gayrard, François Roubille, Stefan Matecki, Alain Lacampagne, Olivier Cazorla
BACKGROUND: The interplay between oxidative stress and other signaling pathways in the contractile machinery regulation during cardiac stress and its consequences on cardiac function remains poorly understood. We evaluated the effect of the crosstalk between β-adrenergic and redox signaling on post-translational modifications of sarcomeric regulatory proteins, Myosin Binding Protein-C (MyBP-C) and Troponin I (TnI). METHODS AND RESULTS: We mimicked in vitro high level of physiological cardiac stress by forcing rat hearts to produce high levels of oxidized glutathione...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29480333/characterization-of-structural-and-functional-role-of-selenocysteine-in-selenoprotein-h-and-its-impact-on-dna-binding
#16
Sagar H Barage, Deepti D Deobagkar, Vijay B Baladhye
Selenoproteins are a group of proteins which contain selenocysteine (Sec or U) in their primary structure. Selenoproteins play a critical role in antioxidant defense, hormone metabolism, immune responses and muscle development. The selenoprotein H (SELENOH) is essential in the regulation of gene expression in response to redox status and antioxidant defense. It has Sec residue located in conserved CXXU motif similar to other selenoproteins. However, exact biological function of Sec residue in SELENOH is not known in detail...
May 2018: Amino Acids
https://www.readbyqxmd.com/read/29480307/retention-of-selenium-by-calcium-aluminate-hydrate-afm-phases-under-strongly-reducing-radioactive-waste-repository-conditions
#17
H Rojo, A C Scheinost, B Lothenbach, A Laube, E Wieland, J Tits
Safety assessment studies of future nuclear waste repositories carried out in many countries predict selenium-79 to be a critical radionuclide due to its presence as anion in three relevant oxidation states (vi, iv, -ii) resulting in weak retardation by most common rock minerals. This assumption, however, ignores its potential uptake by AFm phases, positively charged anion exchangers, which are present in significant quantities in the cementitious materials used in artificial barriers. Here we report for the first time wet chemistry and spectroscopic data on the interaction of the most relevant selenium anion species under the expected strongly reducing conditions, i...
March 28, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29460803/vitamin-d-status-in-children-with-headache-a-case-control-study
#18
A Donmez, E Orun, F M Sonmez
BACKGROUND: Vitamin D is a fat soluble vitamin with hormonal properties, plays crucial functions in bone and mineral metabolism and has important regulatory functions in brain development, cell differentiation and apoptosis. Some studies have shown a link between vitamin D deficiency and headache. MATERIAL AND METHODS: In this study, 147 patients with headache (migraine or either tension-type headache (TTH)) and 69 healthy controls, aged 5 to 16 years, were evaluated...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460355/do-hostile-school-environments-promote-social-deviance-by-shaping-neural-responses-to-social-exclusion
#19
Roberta A Schriber, Christina R Rogers, Emilio Ferrer, Rand D Conger, Richard W Robins, Paul D Hastings, Amanda E Guyer
The present study examined adolescents' neural responses to social exclusion as a mediator of past exposure to a hostile school environment (HSE) and later social deviance, and whether family connectedness buffered these associations. Participants (166 Mexican-origin adolescents, 54.4% female) reported on their HSE exposure and family connectedness across Grades 9-11. Six months later, neural responses to social exclusion were measured. Finally, social deviance was self-reported in Grades 9 and 12. The HSE-social deviance link was mediated by greater reactivity to social deviance in subgenual anterior cingulate cortex, a region from the social pain network also implicated in social susceptibility...
March 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29454088/hsf4-transcriptional-regulates-hmox-1-expression-in-hlecs
#20
Shengjie Liao, Zhen Qu, Linqiang Li, Benwen Zhou, Meng Gao, Mi Huang, Duanzhuo Li
The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation...
May 20, 2018: Gene
keyword
keyword
27413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"