keyword
MENU ▼
Read by QxMD icon Read
search

Hse

keyword
https://www.readbyqxmd.com/read/29665468/validation-of-haplotype-specific-extraction-for-separating-a-mitochondrial-dna-model-mixture-and-application-to-simulated-casework
#1
Judith Zander, Petra Otremba, Marion Nagy
Haplotype-specific extraction (HSE) is a new field of application for the separation of mitochondrial DNA (mtDNA) mixtures and is developed to identify the mtDNA haplotypes of the contributors subsequently by sequencing. Here we show the validation of HSE with an exemplary mitochondrial DNA mixture into its individual haplotypes according to our laboratory standards. These specify several critical areas of assay performance to be tested, such as sensitivity, robustness and mixture studies comprising varying proportions of their components,degraded samples and samples of different qualities and material...
April 11, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29661622/rational-design-and-screening-of-peptide-based-inhibitors-of-heat-shock-factor-1-hsf1
#2
Xu Ran, Eileen T Burchfiel, Bushu Dong, Nicholas J Rettko, Bryan M Dunyak, Hao Shao, Dennis J Thiele, Jason E Gestwicki
Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that regulates expression of protein chaperones and cell survival factors. In cancer, HSF1 plays a unique role, hijacking the normal stress response to drive a cancer-specific transcriptional program. These observations suggest that HSF1 inhibitors could be promising therapeutics. However, HSF1 is activated through a complex mechanism, which involves release of a negative regulatory domain, leucine zipper 4 (LZ4), from a masked oligomerization domain (LZ1-3), and subsequent binding of the oligomer to heat shock elements (HSEs) in HSF1-responsive genes...
April 7, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29561175/diurnal-effects-of-prior-heat-stress-exposure-on-sprint-and-endurance-exercise-capacity-in-the-heat
#3
Hidenori Otani, Mitsuharu Kaya, Akira Tamaki, Heita Goto, Takayuki Goto, Minayuki Shirato
Active individuals often perform exercises in the heat following heat stress exposure (HSE) regardless of the time-of-day and its variation in body temperature. However, there is no information concerning the diurnal effects of a rise in body temperature after HSE on subsequent exercise performance in a hot environnment. This study therefore investigated the diurnal effects of prior HSE on both sprint and endurance exercise capacity in the heat. Eight male volunteers completed four trials which included sprint and endurance cycling tests at 30 °C and 50% relative humidity...
March 21, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29544934/stress-induced-protein-s-glutathionylation-and-phosphorylation-crosstalk-in-cardiac-sarcomeric-proteins-impact-on-heart-function
#4
Nourdine Chakouri, Cyril Reboul, Doria Boulghobra, Adrien Kleindienst, Stéphane Nottin, Sandrine Gayrard, François Roubille, Stefan Matecki, Alain Lacampagne, Olivier Cazorla
BACKGROUND: The interplay between oxidative stress and other signaling pathways in the contractile machinery regulation during cardiac stress and its consequences on cardiac function remains poorly understood. We evaluated the effect of the crosstalk between β-adrenergic and redox signaling on post-translational modifications of sarcomeric regulatory proteins, Myosin Binding Protein-C (MyBP-C) and Troponin I (TnI). METHODS AND RESULTS: We mimicked in vitro high level of physiological cardiac stress by forcing rat hearts to produce high levels of oxidized glutathione...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29480333/characterization-of-structural-and-functional-role-of-selenocysteine-in-selenoprotein-h-and-its-impact-on-dna-binding
#5
Sagar H Barage, Deepti D Deobagkar, Vijay B Baladhye
Selenoproteins are a group of proteins which contain selenocysteine (Sec or U) in their primary structure. Selenoproteins play a critical role in antioxidant defense, hormone metabolism, immune responses and muscle development. The selenoprotein H (SELENOH) is essential in the regulation of gene expression in response to redox status and antioxidant defense. It has Sec residue located in conserved CXXU motif similar to other selenoproteins. However, exact biological function of Sec residue in SELENOH is not known in detail...
February 26, 2018: Amino Acids
https://www.readbyqxmd.com/read/29480307/retention-of-selenium-by-calcium-aluminate-hydrate-afm-phases-under-strongly-reducing-radioactive-waste-repository-conditions
#6
H Rojo, A C Scheinost, B Lothenbach, A Laube, E Wieland, J Tits
Safety assessment studies of future nuclear waste repositories carried out in many countries predict selenium-79 to be a critical radionuclide due to its presence as anion in three relevant oxidation states (vi, iv, -ii) resulting in weak retardation by most common rock minerals. This assumption, however, ignores its potential uptake by AFm phases, positively charged anion exchangers, which are present in significant quantities in the cementitious materials used in artificial barriers. Here we report for the first time wet chemistry and spectroscopic data on the interaction of the most relevant selenium anion species under the expected strongly reducing conditions, i...
February 26, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29460803/vitamin-d-status-in-children-with-headache-a-case-control-study
#7
A Donmez, E Orun, F M Sonmez
BACKGROUND: Vitamin D is a fat soluble vitamin with hormonal properties, plays crucial functions in bone and mineral metabolism and has important regulatory functions in brain development, cell differentiation and apoptosis. Some studies have shown a link between vitamin D deficiency and headache. MATERIAL AND METHODS: In this study, 147 patients with headache (migraine or either tension-type headache (TTH)) and 69 healthy controls, aged 5 to 16 years, were evaluated...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460355/do-hostile-school-environments-promote-social-deviance-by-shaping-neural-responses-to-social-exclusion
#8
Roberta A Schriber, Christina R Rogers, Emilio Ferrer, Rand D Conger, Richard W Robins, Paul D Hastings, Amanda E Guyer
The present study examined adolescents' neural responses to social exclusion as a mediator of past exposure to a hostile school environment (HSE) and later social deviance, and whether family connectedness buffered these associations. Participants (166 Mexican-origin adolescents, 54.4% female) reported on their HSE exposure and family connectedness across Grades 9-11. Six months later, neural responses to social exclusion were measured. Finally, social deviance was self-reported in Grades 9 and 12. The HSE-social deviance link was mediated by greater reactivity to social deviance in subgenual anterior cingulate cortex, a region from the social pain network also implicated in social susceptibility...
March 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29454088/hsf4-transcriptional-regulates-hmox-1-expression-in-hlecs
#9
Shengjie Liao, Zhen Qu, Linqiang Li, Benwen Zhou, Meng Gao, Mi Huang, Duanzhuo Li
The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29439375/burnout-and-work-related-stress-in-italian-rehabilitation-professionals-a-comparison-of-physiotherapists-speech-therapists-and-occupational-therapists
#10
Marco Bruschini, Antonella Carli, Franco Burla
BACKGROUND: Healthcare workers are exposed to work related stresses that significantly increase their risk of burnout. OBJECTIVE: To evaluate and compare burnout and work related stress levels in three categories of health professionals: physiotherapists, speech therapists and occupational therapists. METHODS: A convenience sample of 391 health professionals participated, including 210 physiotherapists, 101 speech therapists and 80 occupational therapists...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29432567/bile-acid-sequestration-by-cholestyramine-mitigates-fgfr4-inhibition-induced-alt-elevation
#11
Heiko S Schadt, Armin Wolf, Joerg Andreas Mahl, Kuno Wuersch, Philippe Couttet, Marianne Schwald, Audrey Fischer, Mathilde Lienard, Corinne Emotte, Chi-Hse Teng, Elizabeth Skuba, Terrilyn A Richardson, Luigi Manenti, Andreas Weiss, Diana Graus Porta, Robin A Fairhurst, Gerd A Kullak-Ublick, Salah-Dine Chibout, Francois Pognan, William Kluwe, Jacqueline Kinyamu-Akunda
The FGF19-FGFR4-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset of liver cancers including hepatocellular carcinoma (HCC), establishing FGFR4 as an attractive therapeutic target for such solid tumors. FGF401 is a highly selective FGFR4 kinase inhibitor being developed for HCC, currently in Phase I/II clinical studies. In preclinical studies in mice and dogs, oral administration of FGF401 led to induction of Cyp7a1, elevation of its peripheral marker 7alpha-hydroxy-4-cholesten-3-one (C4), increased BA pool size, decreased serum cholesterol and diarrhea in dogs...
February 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29380794/real-time-polymerase-chain-reaction-in-acute-retinal-necrosis-following-encephalitis
#12
Vinita Rao, Jyotirmay Biswas, Gopal Lingam
Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29373435/match-play-running-demands-and-technical-performance-among-elite-gaelic-footballers-does-divisional-status-count
#13
Jason H McGahan, Shane Mangan, Kieran Collins, Con Burns, Tim Gabbett, Cian O' Neill
The aim of the current study was to compare positional differences in running demands and technical performance variables among elite Gaelic football teams from separate Divisions. Data were obtained from a Division 1 (26.7 ± 2.9 years, 179.2 ± 21.3 cm, 89.9 ± 21.2 kg) and a Division 3 (25.7 ± 3.5 years, 183.0 ± 4.7 cm, 84.4 ± 6.5 kg) team. Match-play running variables were collected using 4-Hz global positioning system (GPS) units (VX Sport, New-Zealand) (Match data sets; Division 1: n = 107, Division 3: n = 97)...
January 24, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29372949/antenatal-pertussis-vaccination-why-are-general-practitioners-reluctant-a-mixed-methods-studysetting
#14
A O'Connell, A Tummon, K Coleman, A Jordan, J McCormack, M E Kelly
Pertussis has a disproportionately higher morbidity and mortality in infants less than 3 months of age. International and national guidelines recommend pertussis vaccination during pregnancy, as a safe and effective way to protect these infants. Antenatal pertussis vaccination uptake rates remain suboptimal, with many health care professionals (HCPs) still not recommending it. The reasons underlying this reluctance on behalf of HCPs have not been fully established. This study aims to evaluate the current practice and attitudes of General Practitioners (GPs) with regard to antenatal pertussis vaccination...
September 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29372415/presenting-a-conceptual-pattern-of-hse-performance-of-oil-trucks
#15
Sahar Ghaleh, Manouchehr Omidvari, Parvin Nassiri, Mansour Momeni, Seyed Mohammadreza Miri Lavasani
Accidents are among the main problems in the oil product supply chain. The most important effective factors in these events are the kind of trucks used and their health, safety, and environment (HSE) condition. The aim of this study was to present a conceptual pattern of the HSE performance of oil trucks in oil industries. In this study, 20 truck models (with fixed tanks), in use over different periods of time, were investigated. In this regard, the criteria and sub-criteria were first determined in two parts-carrier and tank-and weighted by fuzzy analytical hierarchy process (FAHP)...
January 25, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29363471/defensive-pessimism-self-esteem-and-achievement-goals-a-person-centered-approach
#16
María M Ferradás Canedo, Carlos Freire Rodríguez, Bibiana Regueiro Fernández, Antonio Valle Arias
BACKGROUND: The relationship between defensive pessimism, self-esteem, and achievement goals is a controversial issue. The main contribution of this research is the adoption of a person-centered approach to explore the existence of differentiated profiles of university students, which combine self-esteem and defensive pessimism. In addition, we analyze whether these profiles differ in their achievement goals (learning, performance-approach, performance-avoidance, and work-avoidance). METHOD: 1,028 university students took part in the study...
February 2018: Psicothema
https://www.readbyqxmd.com/read/29360926/opal-prediction-of-morf-regions-in-intrinsically-disordered-protein-sequences
#17
Ronesh Sharma, Gaurav Raicar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
Motivation: Intrinsically disordered proteins lack stable 3-dimensional structure and play a crucial role in performing various biological functions. Key to their biological function are the molecular recognition features (MoRFs) located within long disordered protein sequences. Computationally identifying these MoRFs is a challenging task. In this study, we present a new MoRF predictor, OPAL, to identify MoRFs in disordered protein sequences. Method: OPAL utilizes two independent sources of information computed using different component predictors whose scores are processed and combined using common averaging method...
January 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29356973/pitfalls-in-clinical-diagnosis-of-anti-nmda-receptor-encephalitis
#18
Atsushi Kaneko, Juntaro Kaneko, Naomi Tominaga, Naomi Kanazawa, Kasumi Hattori, Yoshikazu Ugawa, Arata Moriya, Daisuke Kuzume, Daisuke Ishima, Eiji Kitamura, Kazutoshi Nishiyama, Takahiro Iizuka
OBJECTIVES: To report pitfalls in the clinical diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHODS: We retrospectively reviewed the clinical information of 221 patients with clinically suspected autoimmune neurological disorders who underwent testing for autoantibodies against neuronal cell-surface antigens between January 1, 2007 and September 10, 2017. Forty-one patients met the diagnostic criteria for probable anti-NMDAR encephalitis (probable criteria), but one was excluded because neither serum nor CSF was examined at the active stage...
March 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29352287/ifn%C3%AE-inhibits-g-csf-induced-neutrophil-expansion-and-invasion-of-the-cns-to-prevent-viral-encephalitis
#19
Chandran Ramakrishna, Edouard M Cantin
Emergency hematopoiesis facilitates the rapid expansion of inflammatory immune cells in response to infections by pathogens, a process that must be carefully regulated to prevent potentially life threatening inflammatory responses. Here, we describe a novel regulatory role for the cytokine IFNγ that is critical for preventing fatal encephalitis after viral infection. HSV1 encephalitis (HSE) is triggered by the invasion of the brainstem by inflammatory monocytes and neutrophils. In mice lacking IFNγ (GKO), we observed unrestrained increases in G-CSF levels but not in GM-CSF or IL-17...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29334395/probing-the-geometry-of-copper-and-silver-adatoms-on-magnetite-quantitative-experiment-versus-theory
#20
Matthias Meier, Zdeněk Jakub, Jan Balajka, Jan Hulva, Roland Bliem, Pardeep K Thakur, Tien-Lin Lee, Cesare Franchini, Michael Schmid, Ulrike Diebold, Francesco Allegretti, David A Duncan, Gareth S Parkinson
Accurately modelling the structure of a catalyst is a fundamental prerequisite for correctly predicting reaction pathways, but a lack of clear experimental benchmarks makes it difficult to determine the optimal theoretical approach. Here, we utilize the normal incidence X-ray standing wave (NIXSW) technique to precisely determine the three dimensional geometry of Ag1 and Cu1 adatoms on Fe3 O4 (001). Both adatoms occupy bulk-continuation cation sites, but with a markedly different height above the surface (0...
February 1, 2018: Nanoscale
keyword
keyword
27413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"