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Laura Krogh Jørgensen, Lars Skov Dalgaard, Lars Jørgen Østergaard, Mette Nørgaard, Trine Hyrup Mogensen
OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort. METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality...
October 4, 2016: Journal of Infection
Adel Mesbah, Jai Prakash, James A Ibers
This review focuses on the results of exploratory syntheses of alkaline-earth-metal actinide chalcogenides Ak-An-Q (Ak = Ba, Sr; An = Th, U; Q = S, Se, and Te). About thirty new compounds are described. Although the basic building blocks of their structures are usually AnQ6 octahedra and AkQ8 bicapped trigonal prisms, these are combined in diverse ways to afford eleven new structure types. The structures reconfirm the prevailing presence of An(4+) in chalcogenides, although some of the compounds discovered are mixed An(4+)/An(5+) systems, and a few contain only An(5+)...
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Alejandro J Garza, Gustavo E Scuseria
We compare the ability of four popular hybrid density functionals (B3LYP, B3PW91, HSE, and PBE0) for predicting band gaps of semiconductors and insulators over a large benchmark set using a consistent methodology. We observe no significant statistical difference in their overall performance although the screened hybrid HSE is more accurate for typical semiconductors. HSE can improve its accuracy for large large band gap materials --without affecting that of semiconductors-- by including a larger portion of Hartree--Fock exchange in its short range...
October 5, 2016: Journal of Physical Chemistry Letters
Chunkui Zhou, Lijun Zhu, Shaokuan Fang
Herpes simplex virus (HSV) is the most common cause of acute viral encephalitis. Acute retinal necrosis (ARN) is a rapidly progressing and potentially blinding eye disease that may be induced by HSV. The present case study reports the very rare case of a patient with herpes simplex encephalitis (HSE) combined with acute retinal necrosis (ARN). A 47-year-old woman was admitted to hospital with persistent high fever and somnolence for 5 days. Magnetic resonance imaging showed abnormal signals in the right medial temporal lobes, and HSV-1 was identified in the serum and cerebrospinal fluid...
October 2016: Experimental and Therapeutic Medicine
Jian Li, Laetitia Chauve, Grace Phelps, Renée M Brielmann, Richard I Morimoto
Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response (HSR) and is essential for stress resilience. HSF is also required for metazoan development; however, its function and regulation in this process are poorly understood. Here, we characterize the genomic distribution and transcriptional activity of Caenorhabditis elegans HSF-1 during larval development and show that the developmental HSF-1 transcriptional program is distinct from the HSR. HSF-1 developmental activation requires binding of E2F/DP to a GC-rich motif that facilitates HSF-1 binding to a heat-shock element (HSE) that is degenerate from the consensus HSE sequence and adjacent to the E2F-binding site at promoters...
September 29, 2016: Genes & Development
Hussein Algahtani, Bader Shirah, Mohammed Hmoud, Ahmad Subahi
Herpes simplex encephalitis (HSE) is a rare disease, but it is the most common form of sporadic encephalitis. HSE is transmitted through direct contact and developing nosocomial HSE is rarely reported in the literature. Nosocomial HSE is difficult to diagnose due to its non-specific clinical features. In this article, we present a case of nosocomial HSE that was responsible for grave consequence. We also explore its causes, outcome, and give recommendations to avoid such fatal occurrence. We stress on strict adherence to the standard precautions and preventive control measures...
September 24, 2016: Journal of Infection and Public Health
E Shanahan, C Henderson, A Butler, B Lenehan, T Sheehy, A Costelloe, S Carew, C Peters, M O'Connor, D Lyons, J Ryan
Hip fracture is common in older adults and is associated with high morbidity, mortality and significant health care costs. A pilot orthogeriatrics service was established in an acute hospital. We aimed to establish the cost effectiveness of this service. Length of hospital stay, discharge destination and rehabilitation requirements were analysed for a one year period and compared to patients who received usual care prior to the service. We calculated the costs incurred and savings produced by the orthogeriatric service...
2016: Irish Medical Journal
Yan Zhang, Baohong Zou, Shan Lu, Yuan Ding, He Liu, Jian Hua
Small heat shock proteins (sHSPs) are molecular chaperones important for stress tolerance. In this study, heat induction of a rice sHSP gene OsHSP16.9C is analyzed to understand the molecular mechanisms underlying gene expression regulation in heat shock responses in rice. Promoter deletion analysis of the OsHSP16.9C using the luciferase (LUC) reporter gene in transgenic rice identifies a critical role of a promoter fragment containing an imperfect heat shock element (HSE) in heat induction. HSE was shown to be important for heat induction of AtHSP18...
October 14, 2016: Biochemical and Biophysical Research Communications
Oluwatoyin M A Ogundele, Olugbenga O Awolu, Adebanjo A Badejo, Ifeanyi D Nwachukwu, Tayo N Fagbemi
The demand for functional foods and drinks with health benefit is on the increase. The synergistic effect from mixing two or more of such drinks cannot be overemphasized. This study was carried out to formulate and investigate the effects of blends of two or more of pineapple, orange juices, carrot, and Hibiscus sabdariffa extracts (HSE) on the antioxidant properties of the juice formulations in order to obtain a combination with optimal antioxidant properties. Experimental design was carried out using optimal mixture model of response surface methodology which generated twenty experimental runs with antioxidant properties as the responses...
September 2016: Food Science & Nutrition
Esfandiar Azad-Marzabadi, Mohammad Gholami Fesharaki
BACKGROUND: In recent years, job stress has been cited as a risk factor for some diseases. OBJECTIVES: Given the importance of this subject, we established a new model for classifying job stress among Iranian male staff using path analysis. MATERIALS AND METHODS: This cross-sectional study was done on male staff in Tehran, Iran, 2013. The participants in the study were selected using a proportional stratum sampling method. The tools used included nine questionnaires (1- HSE questionnaire; 2- GHQ questionnaire; 3- Beck depression inventory; 4- Framingham personality type; 5- Azad-Fesharaki's physical activity questionnaire; 6- Adult attachment style questionnaire; 7- Azad socioeconomic questionnaire; 8- Job satisfaction survey; and 9- demographic questionnaire)...
June 2016: Iranian Red Crescent Medical Journal
Theo Scheffers, Blandine Doornaert, Nathalie Berne, Gerard van Breukelen, Antoine Leplay, Erik van Miert
Hazard Banding (HB) is a process of allocating chemical substances in bands of increasing health hazard based on their hazard classifications. Recent Control Banding (CB) tools use the classifications of the United Nations Global Harmonized System (UN GHS) or the European Union Classifications, Labelling and Packaging (EU CLP) which are grouped over 5 HBs. The use of CB is growing worldwide for the risk control of substances without an Occupational Exposure Limit Value (OELV). Well-known CB-tools like HSE-COSHH Essentials, BAuA-Einfaches Maßnahmenkonzept Gefahrstoffe (EMKG), and DGUV-IFA-Spaltenmodell (IFA) use however different GHS/CLP groupings which may lead to dissimilar HBs and control regimes for individual substances...
September 12, 2016: Annals of Occupational Hygiene
Alessio Malacrida, Daniele Maggioni, Arianna Cassetti, Gabriella Nicolini, Guido Cavaletti, Mariarosaria Miloso
Cancer is a leading cause of death worldwide. Despite therapeutic improvements, some cancers are still untreatable. Recently there has been an increasing interest in the use of natural substances for cancer prevention and treatment. Hibiscus sabdariffa (HS) is a plant, belonging to Malvaceae family, widespread in South Asia and Central Africa. HS extract (HSE) used in folk medicine, gained researchers' interest thanks to its antioxidant, anti-inflammatory, and chemopreventive properties. In the present study, we initially assessed HSE effect on a panel of human tumor cell lines...
October 2016: Nutrition and Cancer
David C Rubie, Vera Laurenz, Seth A Jacobson, Alessandro Morbidelli, Herbert Palme, Antje K Vogel, Daniel J Frost
Highly siderophile elements (HSEs) are strongly depleted in the bulk silicate Earth (BSE) but are present in near-chondritic relative abundances. The conventional explanation is that the HSEs were stripped from the mantle by the segregation of metal during core formation but were added back in near-chondritic proportions by late accretion, after core formation had ceased. Here we show that metal-silicate equilibration and segregation during Earth's core formation actually increased HSE mantle concentrations because HSE partition coefficients are relatively low at the high pressures of core formation within Earth...
September 9, 2016: Science
Huei-Ru Fuh, Ching-Ray Chang, Yin-Kuo Wang, Richard F L Evans, Roy W Chantrell, Horng-Tay Jeng
We present a newtype 2-dimensional (2D) magnetic semiconductor based on transition-metal dichalcogenides VX2 (X = S, Se and Te) via first-principles calculations. The obtained indirect band gaps of monolayer VS2, VSe2, and VTe2 given from the generalized gradient approximation (GGA) are respectively 0.05, 0.22, and 0.20 eV, all with integer magnetic moments of 1.0 μB. The GGA plus on-site Coulomb interaction U (GGA + U) enhances the exchange splittings and raises the energy gap up to 0.38~0.65 eV...
2016: Scientific Reports
Lindsay Richards, Marii Paskov
A body of academic research has shown a social class gradient in psychological well-being. Some recent work has also suggested that the gradient is worsening over time, though the evidence is mixed. We focus on two straightforward research questions: Is there a class gradient in mental health? Has this gradient changed over time? We answer these questions with attention to two specific causal pathways: employment status and unobserved heterogeneity. We use two data sources: repeated cross-sections from the Health Survey of England (HSE) and longitudinal data from the British Household Panel Survey (BHPS)...
October 2016: Social Science & Medicine
Bin Zhang, Jianguo Chen, Qichuan Jiang, Xuefeng Wang, Yan Lu, Liang Gong, Dong Chen
A rapid, specific and sensitive ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for determination of isofraxidin, rosmarinic acid and kaempferol-3-O-glucuronide in rat plasma using warfarin as an internal standard (IS). Separation was conducted on a Thermo Hypersil GOLD C18 column with linear gradient elution using methanol and water. Mass spectrometric detection was conducted using selected reaction monitoring (SRM) via an electrospray ionization (ESI) source...
September 3, 2016: Biomedical Chromatography: BMC
Malte Niklas Bongers, Georg Bier, Hendrik Ditt, Robert Beck, Ulrike Ernemann, Konstantin Nikolaou, Marius Horger
OBJECTIVE: The purpose of this study is to compare the diagnostic efficacy of a new CT postprocessing tool based on frequency-selective nonlinear blending (best-contrast CT) with that of standard linear blending of unenhanced head CT in patients with herpes simplex virus type 1 and herpes simplex virus encephalitis (HSE), using FLAIR MRI sequences as the standard of reference. MATERIALS AND METHODS: Fifteen consecutive patients (six women and nine men; mean [± SD] age, 60 ± 19 years) with proven HSE (positive polymerase chain reaction results from CSF analysis and the presence of neurologic deficits) were retrospectively enrolled...
November 2016: AJR. American Journal of Roentgenology
Yu Meng, Xing-Wu Liu, Chun-Fang Huo, Wen-Ping Guo, Dong-Bo Cao, Qing Peng, Albert Dearden, Xavier Gonze, Yong Yang, Jianguo Wang, Haijun Jiao, Yongwang Li, Xiao-Dong Wen
Three density functional approximations (DFAs), PBE, PBE+U, and Heyd-Scuseria-Ernzerhof screened hybrid functional (HSE), were employed to investigate the geometric, electronic, magnetic, and thermodynamic properties of four iron oxides, namely, α-FeOOH, α-Fe2O3, Fe3O4, and FeO. Comparing our calculated results with available experimental data, we found that HSE (a = 0.15) (containing 15% "screened" Hartree-Fock exchange) can provide reliable values of lattice constants, Fe magnetic moments, band gaps, and formation energies of all four iron oxides, while standard HSE (a = 0...
October 11, 2016: Journal of Chemical Theory and Computation
C Piernas, P Aveyard, S A Jebb
BackgroundPublic policies and clinical guidelines encourage people to achieve and maintain a healthy weight, and societal culture, especially among women, tends to idealise thinness.ObjectivesTo examine trends over time in the prevalence of weight loss attempts in England (1997-2013) and to investigate if the characteristics associated with attempts to lose weight have changed.MethodsObservational study using nationally representative data on adults ≥18y who participated in the Health Survey for England (HSE) in 1997 (n=8,066), 1998 (n=14,733), 2002 (n=8,803), 2012 (n=7,132) and 2013 (n=7,591), with self-reported attempts to lose weight, cardiovascular disease (CVD) events or medications and measured height, weight and blood pressure...
August 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
G Westman, M Studahl, C Ahlm, B M Eriksson, B Persson, J Rönnelid, S Schliamser, E Aurelius
OBJECTIVES: To investigate the prevalence and temporal development of N-methyl-d-aspartate receptor (NMDAR) autoantibodies in relation to neurocognitive performance in patients with herpes simplex encephalitis (HSE). METHODS: This prospective observational study enrolled a total of 49 HSE patients within a randomized controlled trial of valacyclovir. Cerebrospinal fluid and serum samples were drawn in the initial stage of disease, after 2 to 3 weeks and after 3 months...
August 3, 2016: Clinical Microbiology and Infection
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