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https://www.readbyqxmd.com/read/29454088/hsf4-transcriptional-regulates-hmox-1-expression-in-hlecs
#1
Shengjie Liao, Zhen Qu, Linqiang Li, Benwen Zhou, Meng Gao, Mi Huang, Duanzhuo Li
The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29439375/burnout-and-work-related-stress-in-italian-rehabilitation-professionals-a-comparison-of-physiotherapists-speech-therapists-and-occupational-therapists
#2
Marco Bruschini, Antonella Carli, Franco Burla
BACKGROUND: Healthcare workers are exposed to work related stresses that significantly increase their risk of burnout. OBJECTIVE: To evaluate and compare burnout and work related stress levels in three categories of health professionals: physiotherapists, speech therapists and occupational therapists. METHODS: A convenience sample of 391 health professionals participated, including 210 physiotherapists, 101 speech therapists and 80 occupational therapists...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29432567/bile-acid-sequestration-by-cholestyramine-mitigates-fgfr4-inhibition-induced-alt-elevation
#3
Heiko S Schadt, Armin Wolf, Joerg Andreas Mahl, Kuno Wuersch, Philippe Couttet, Marianne Schwald, Audrey Fischer, Mathilde Lienard, Corinne Emotte, Chi-Hse Teng, Elizabeth Skuba, Terrilyn A Richardson, Luigi Manenti, Andreas Weiss, Diana Graus Porta, Robin A Fairhurst, Gerd A Kullak-Ublick, Salah-Dine Chibout, Francois Pognan, William Kluwe, Jacqueline Kinyamu-Akunda
The FGF19-FGFR4-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset of liver cancers including hepatocellular carcinoma (HCC), establishing FGFR4 as an attractive therapeutic target for such solid tumors. FGF401 is a highly selective FGFR4 kinase inhibitor being developed for HCC, currently in Phase I/II clinical studies. In preclinical studies in mice and dogs, oral administration of FGF401 led to induction of Cyp7a1, elevation of its peripheral marker 7alpha-hydroxy-4-cholesten-3-one (C4), increased BA pool size, decreased serum cholesterol and diarrhea in dogs...
February 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29380794/real-time-polymerase-chain-reaction-in-acute-retinal-necrosis-following-encephalitis
#4
Vinita Rao, Jyotirmay Biswas, Gopal Lingam
Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29373435/match-play-running-demands-and-technical-performance-among-elite-gaelic-footballers-does-divisional-status-count
#5
Jason H McGahan, Shane Mangan, Kieran Collins, Con Burns, Tim Gabbett, Cian O' Neill
The aim of the current study was to compare positional differences in running demands and technical performance variables among elite Gaelic football teams from separate Divisions. Data were obtained from a Division 1 (26.7 ± 2.9 years, 179.2 ± 21.3 cm, 89.9 ± 21.2 kg) and a Division 3 (25.7 ± 3.5 years, 183.0 ± 4.7 cm, 84.4 ± 6.5 kg) team. Match-play running variables were collected using 4-Hz global positioning system (GPS) units (VX Sport, New-Zealand) (Match data sets; Division 1: n = 107, Division 3: n = 97)...
January 24, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29372949/antenatal-pertussis-vaccination-why-are-general-practitioners-reluctant-a-mixed-methods-studysetting
#6
A O'Connell, A Tummon, K Coleman, A Jordan, J McCormack, M E Kelly
Pertussis has a disproportionately higher morbidity and mortality in infants less than 3 months of age. International and national guidelines recommend pertussis vaccination during pregnancy, as a safe and effective way to protect these infants. Antenatal pertussis vaccination uptake rates remain suboptimal, with many health care professionals (HCPs) still not recommending it. The reasons underlying this reluctance on behalf of HCPs have not been fully established. This study aims to evaluate the current practice and attitudes of General Practitioners (GPs) with regard to antenatal pertussis vaccination...
September 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29372415/presenting-a-conceptual-pattern-of-hse-performance-of-oil-trucks
#7
Sahar Ghaleh, Manouchehr Omidvari, Parvin Nassiri, Mansour Momeni, Seyed Mohammadreza Miri Lavasani
Accidents are among the main problems in the oil product supply chain. The most important effective factors in these events are the kind of trucks used and their health, safety, and environment (HSE) condition. The aim of this study was to present a conceptual pattern of the HSE performance of oil trucks in oil industries. In this study, 20 truck models (with fixed tanks), in use over different periods of time, were investigated. In this regard, the criteria and sub-criteria were first determined in two parts-carrier and tank-and weighted by fuzzy analytical hierarchy process (FAHP)...
January 25, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29363471/defensive-pessimism-self-esteem-and-achievement-goals-a-person-centered-approach
#8
María M Ferradás Canedo, Carlos Freire Rodríguez, Bibiana Regueiro Fernández, Antonio Valle Arias
BACKGROUND: The relationship between defensive pessimism, self-esteem, and achievement goals is a controversial issue. The main contribution of this research is the adoption of a person-centered approach to explore the existence of differentiated profiles of university students, which combine self-esteem and defensive pessimism. In addition, we analyze whether these profiles differ in their achievement goals (learning, performance-approach, performance-avoidance, and work-avoidance). METHOD: 1,028 university students took part in the study...
February 2018: Psicothema
https://www.readbyqxmd.com/read/29360926/opal-prediction-of-morf-regions-in-intrinsically-disordered-protein-sequences
#9
Ronesh Sharma, Gaurav Raicar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
Motivation: Intrinsically disordered proteins lack stable 3-dimensional structure and play a crucial role in performing various biological functions. Key to their biological function are the molecular recognition features (MoRFs) located within long disordered protein sequences. Computationally identifying these MoRFs is a challenging task. In this study, we present a new MoRF predictor, OPAL, to identify MoRFs in disordered protein sequences. Method: OPAL utilizes two independent sources of information computed using different component predictors whose scores are processed and combined using common averaging method...
January 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29356973/pitfalls-in-clinical-diagnosis-of-anti-nmda-receptor-encephalitis
#10
Atsushi Kaneko, Juntaro Kaneko, Naomi Tominaga, Naomi Kanazawa, Kasumi Hattori, Yoshikazu Ugawa, Arata Moriya, Daisuke Kuzume, Daisuke Ishima, Eiji Kitamura, Kazutoshi Nishiyama, Takahiro Iizuka
OBJECTIVES: To report pitfalls in the clinical diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHODS: We retrospectively reviewed the clinical information of 221 patients with clinically suspected autoimmune neurological disorders who underwent testing for autoantibodies against neuronal cell-surface antigens between January 1, 2007 and September 10, 2017. Forty-one patients met the diagnostic criteria for probable anti-NMDAR encephalitis (probable criteria), but one was excluded because neither serum nor CSF was examined at the active stage...
January 22, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29352287/ifn%C3%AE-inhibits-g-csf-induced-neutrophil-expansion-and-invasion-of-the-cns-to-prevent-viral-encephalitis
#11
Chandran Ramakrishna, Edouard M Cantin
Emergency hematopoiesis facilitates the rapid expansion of inflammatory immune cells in response to infections by pathogens, a process that must be carefully regulated to prevent potentially life threatening inflammatory responses. Here, we describe a novel regulatory role for the cytokine IFNγ that is critical for preventing fatal encephalitis after viral infection. HSV1 encephalitis (HSE) is triggered by the invasion of the brainstem by inflammatory monocytes and neutrophils. In mice lacking IFNγ (GKO), we observed unrestrained increases in G-CSF levels but not in GM-CSF or IL-17...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29334395/probing-the-geometry-of-copper-and-silver-adatoms-on-magnetite-quantitative-experiment-versus-theory
#12
Matthias Meier, Zdeněk Jakub, Jan Balajka, Jan Hulva, Roland Bliem, Pardeep K Thakur, Tien-Lin Lee, Cesare Franchini, Michael Schmid, Ulrike Diebold, Francesco Allegretti, David A Duncan, Gareth S Parkinson
Accurately modelling the structure of a catalyst is a fundamental prerequisite for correctly predicting reaction pathways, but a lack of clear experimental benchmarks makes it difficult to determine the optimal theoretical approach. Here, we utilize the normal incidence X-ray standing wave (NIXSW) technique to precisely determine the three dimensional geometry of Ag1 and Cu1 adatoms on Fe3O4(001). Both adatoms occupy bulk-continuation cation sites, but with a markedly different height above the surface (0.43 ± 0...
January 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29328055/an-analysis-of-radon-levels-in-the-basements-of-uk-workplaces-and-review-of-when-employers-should-test
#13
Tracy Dawn Gooding
Radon is a recognised lung carcinogen. The main source of radon in UK buildings is the ground. As basements have more ground contact than other parts of a building, and often limited ventilation, there is an increased potential for high radon levels to occur. Regulations are in place in the UK to control radon exposures at work, which prompt employers to undertake risk assessments, test where necessary and take action if levels exceed certain thresholds. Both Public Health England (PHE) and the Health and Safety Executive (HSE) currently advise employers to test routinely occupied basements for radon, irrespective of geographical location; the minimum annual occupancy threshold has been established as one hour per week (approximately 50 hours per year)...
January 12, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29327688/empirical-optimization-of-dft%C3%A2-%C3%A2-%C3%A2-%C3%A2-u-and-hse-for-the-band-structure-of-zno
#14
Keshab Bashyal, Christopher K Pyles, Sajjad Afroosheh, Aneer Lamichhane, Alexey T Zayak
ZnO is a well-known wide band gap semiconductor with promising potential for applications in optoelectronics, transparent electronics, and spintronics. Computational simulations based on the density functional theory (DFT) play an important role in the research of ZnO, but the standard functionals, like Perdew-Burke-Erzenhof, result in largely underestimated values of the band gap and the binding energies of the Zn3d electrons. Methods like DFT  +  U and hybrid functionals are meant to remedy the weaknesses of plain DFT...
January 12, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29305044/functional-failure-of-tlr3-and-its-signaling-components-contribute-to-herpes-simplex-encephalitis
#15
REVIEW
Matylda Barbara Mielcarska, Magdalena Bossowska-Nowicka, Felix Ngosa Toka
Herpes simplex encephalitis (HSE) is a severe neurological disease in children and adults caused by herpes simplex virus. This review discusses recent findings on the role of Toll-like receptor 3 (TLR3) deficiencies in the HSE development. Critical checkpoints in the TLR3 signaling that contribute to innate response are discussed, including the importance of TLR3 ligand recognition site and transportation in the cell. We also indicate unresolved issues in the TLR3 functioning that might lead to thorough understanding of immunity during HSE...
December 18, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29303174/oxygen-induced-degradation-of-the-electronic-properties-of-thin-layer-inse
#16
Xin Wei, Chaofang Dong, Aoni Xu, Xiaogang Li, Digby D Macdonald
Thin-layer indium selenide (InSe) compounds, as two-dimensional (2D) semiconductors, have been widely and intensively studied due to their high electron mobility and environmental stability. Here, we report a study demonstrating the oxygen-induced degradation of monolayer and bilayer InSe nanosheets using first-principles calculations and deformation potential theory. It is evident that O atoms prefer to substitute Se atoms instead of undergoing adsorption onto surfaces, while interstitial sites are the most stable adsorption sites of O atoms in the interior for both monolayer and bilayer InSe...
January 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29294936/the-effect-of-the-moscow-theatre-siege-on-expectations-of-well-being-in-the-future
#17
Margarita Vorsina, Matthew Manning, Christopher M Fleming, Christine Smith
We employ the Russia Longitudinal Monitoring Survey-Higher School of Economics (RLMS-HSE), a survey of 6,000 individuals, and a difference-in-differences estimation strategy to examine the effect of the 2002 Moscow theatre siege on the level of self-reported expectations of life in the future of the Russian population. The longitudinal nature of the data allows us to explore both the short- and long-term effects of terrorism on this population as well as contribute to the limited number of quasi-experimental studies in this area...
September 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29280154/performance-of-range-separated-hybrid-exchange-correlation-functionals-for-the-calculation-of-magnetic-exchange-coupling-constants-of-organic-diradicals
#18
Suranjan Shil, Carmen Herrmann
The prediction of magnetic behavior is important for the design of new magnetic materials. Kohn-Sham density functional theory is popular for this purpose, although one should be careful about choosing the right exchange-correlation functional. Here, we perform a statistical analysis to test different range-separated hybrid density functionals for the calculation of magnetic exchange coupling constants J of fourteen organic diradicals. Our analysis suggests that in absolute terms the MN12SX functional performs best among the series of twelve functionals studied here (including the popular B3LYP), followed by N12SX functionals along with Scuseria's HSE series of functionals...
December 26, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29277332/cytokine-chemokine-elevation-during-the-transition-phase-from-hsv-encephalitis-to-autoimmune-anti-nmda-receptor-encephalitis
#19
Takanori Omae, Yoshiaki Saito, Hirokazu Tsuchie, Koyo Ohno, Yoshihiro Maegaki, Hiroshi Sakuma
A 3-year-old girl suffered from anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis after resolution of herpes simplex virus encephalitis (HSE). Methylprednisolone pulse and immunoglobulin therapies showed little effect, but the patient completely recovered after six courses of monthly cyclophosphamide pulse therapy and successive maintenance on mycophenolate mofetil for one year. Anti-NMDA receptor antibody in the cerebrospinal fluid (CSF) was minimally detected during the prodromal febrile period and then was seen to be markedly elevated at the onset of second encephalopathy phase...
December 22, 2017: Brain & Development
https://www.readbyqxmd.com/read/29274746/structural-covariance-networks-are-coupled-to-expression-of-genes-enriched-in-supragranular-layers-of-the-human-cortex
#20
Rafael Romero-Garcia, Kirstie J Whitaker, František Váša, Jakob Seidlitz, Maxwell Shinn, Peter Fonagy, Raymond J Dolan, Peter B Jones, Ian M Goodyer
Complex network topology is characteristic of many biological systems, including anatomical and functional brain networks (connectomes). Here, we first constructed a structural covariance network from MRI measures of cortical thickness on 296 healthy volunteers, aged 14-24 years. Next, we designed a new algorithm for matching sample locations from the Allen Brain Atlas to the nodes of the SCN. Subsequently we used this to define, transcriptomic brain networks by estimating gene co-expression between pairs of cortical regions...
December 21, 2017: NeuroImage
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