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https://www.readbyqxmd.com/read/27919480/extratemporal-herpes-encephalitis-during-natalizumab-treatment-a-case-report
#1
Shalom Haggiag, Luca Prosperini, Simonetta Galgani, Carlo Pozzilli, Carmela Pinnetti
Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We report a MS patient under natalizumab treatment with HSE, who presented with MRI lesions exclusively in the right parietal lobe. The patient was timely started on acyclovir resulting in marked improvement...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27914480/mother-child-interactions-and-young-child-behavior-during-procedural-conscious-sedation
#2
Daniella Miranda-Remijo, Mara Rúbia Orsini, Patrícia Corrêa-Faria, Luciane Rezende Costa
BACKGROUND: As many preschoolers are not able to cooperate with health-related invasive procedures, sedation can help with the child's comfort and allow the intervention to be done. It is scarcely known how parents affect children's behavior during dental treatment under conscious sedation. The aim of this exploratory study was to analyze the association between mother-child interactions in day-to-day family life and preschool children's behavior during dental treatment under conscious sedation...
December 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27909291/engineering-of-a-thermostable-esterase-est816-to-improve-its-quorum-quenching-activity-and-the-underlying-structural-basis
#3
Xiwen Liu, Li-Chuang Cao, Xin-Jiong Fan, Yu-Huan Liu, Wei Xie
N-acyl-homoserine lactones (AHLs) are small diffusible molecules called autoinducers that mediate cell-to-cell communications. Enzymatic degradation of AHLs is a promising bio-control strategy known as quorum-quenching. To improve the quorum-quenching activity of a thermostable esterase Est816, which had been previously cloned, we have engineered the enzyme by random mutagenesis. One of the mutants M2 with double amino acid substitutions (A216V/K238N) showed 3-fold improvement on catalytic efficiency. Based on the crystal structure determined at 2...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909158/off-site-emergency-planning-at-uk-nuclear-licensed-sites
#4
Paul Leonard, Gareth Thomas
Nuclear emergency planning arrangements in the UK are continually kept under review. This work proposes to outline how experience from nuclear exercises and undertaking emergency response duties can be based on radiological knowledge of specific sites and utilised in the future. In 2014, the UK regulator, the Office for Nuclear Regulation (ONR) revised their principles for the determination of off-site emergency planning areas around nuclear sites where predetermined countermeasures and other protection measures are applied to protect those people who may be affected by a radiation emergency...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27902351/protective-role-of-cx3cr1-signaling-in-resident-cells-of-the-central-nervous-system-during-experimental-herpes-simplex-virus-encephalitis
#5
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin
CX3CR1 is an important chemokine receptor expressed on the surface of microglia and blood leukocytes including monocytes. Signaling through this receptor influences the immune activity of microglia and monocytes trafficking into the central nervous system (CNS) in several neurological diseases. During experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE), CX3CR1 deficiency has been reported to exacerbate the outcome of the disease. However, the precise contribution of CX3CR1 expressed in resident cells of the CNS or peripheral monocytes in protection against HSE remains unclear...
November 30, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27879667/biological-chemistry-of-hydrogen-selenide
#6
REVIEW
Kellye A Cupp-Sutton, Michael T Ashby
There are no two main-group elements that exhibit more similar physical and chemical properties than sulfur and selenium. Nonetheless, Nature has deemed both essential for life and has found a way to exploit the subtle unique properties of selenium to include it in biochemistry despite its congener sulfur being 10,000 times more abundant. Selenium is more easily oxidized and it is kinetically more labile, so all selenium compounds could be considered to be "Reactive Selenium Compounds" relative to their sulfur analogues...
November 22, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27875994/do-primary-care-professionals-agree-about-progress-with-implementation-of-primary-care-teams-results-from-a-cross-sectional-study
#7
E Tierney, M O'Sullivan, L Hickey, A Hannigan, C May, W Cullen, N Kennedy, L Kineen, A MacFarlane
BACKGROUND: Primary care is the cornerstone of healthcare reform with policies across jurisdictions promoting interdisciplinary team working. The effective implementation of such health policies requires understanding the perspectives of all actors. However, there is a lack of research about health professionals' views of this process. This study compares Primary Healthcare Professionals' perceptions of the effectiveness of the Primary Care Strategy and Primary Care Team (PCT) implementation in Ireland...
November 22, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27871327/ebola-zika-and-the-international-health-regulations-implications-for-port-health-preparedness
#8
R W Glynn, M Boland
BACKGROUND: The outbreak of Ebola Virus Disease in West Africa in 2014-2015 was unprecedented in terms of its scale and consequence.  This, together with the emergence of Zika virus as a Public Health Emergency of International Concern in 2016, has again highlighted the potential for disease to spread across international borders and provided an impetus for countries to review their Port Health preparedness. This report reviews the legislative framework and actions taken under this framework in advancing and improving Port Health preparedness in Ireland, in response to the declaration of the Public Health Emergency of International Concern for Ebola Virus Disease in August 2014...
November 21, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27866167/rewiring-of-signaling-networks-modulating-thermotolerance-in-the-human-pathogen-cryptococcus-neoformans
#9
Dong-Hoon Yang, Kwang-Woo Jung, Soohyun Bang, Jang-Won Lee, Min-Hee Song, Anna Floyd-Averette, Richard A Festa, Giuseppe Ianiri, Alexander Idnurm, Dennis J Thiele, Joseph Heitman, Yong-Sun Bahn
Thermotolerance is a crucial virulence attribute for human pathogens, including the fungus Cryptococcus neoformans that causes fatal meningitis in humans. Loss of the protein kinase Sch9 increases C. neoformans thermotolerance, but its regulatory mechanism has remained unknown. Here, we studied the Sch9-dependent and Sch9-independent signaling networks modulating C. neoformans thermotolerance by using genome-wide transcriptome analysis and reverse genetic approaches. During temperature upshift, genes encoding for molecular chaperones and heat shock proteins were upregulated, whereas those for translation, transcription, and sterol biosynthesis were highly suppressed...
November 18, 2016: Genetics
https://www.readbyqxmd.com/read/27862521/design-of-an-optimal-promoter-involved-in-the-heat-induced-transcriptional-pathway-in-arabidopsis-soybean-rice-and-maize
#10
Kyonoshin Maruyama, Takuya Ogata, Norihito Kanamori, Kyouko Yoshiwara, Shingo Goto, Yoshiharu Y Yamamoto, Yuko Tokoro, Chihiro Noda, Yuta Takaki, Hiroko Urawa, Satoshi Iuchi, Kaoru Urano, Takuhiro Yoshida, Tetsuya Sakurai, Mikiko Kojima, Hitoshi Sakakibara, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Interactions between heat shock factor (HSF) and the heat shock response element (HSE) are important during the heat shock response (HSR) of flora and fauna. Moreover, plant HSFs that are involved in heat stress are also involved in abiotic stresses such as dehydration and cold as well as development, cell differentiation, and proliferation. Because the specific combination of HSFs and HSEs involved in plants under heat stress remains unclear, the mechanism of their interaction has not yet been utilized in plant molecular breeding for climate change...
November 15, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27845493/ionizing-radiation-and-stress-the-analysis-of-the-medical-ray-technician
#11
S De Sio, D Mandolesi, V Colasanti, C Goglia, S Cuzzola, M Di Traglia, E Greco
BACKGROUND: The present study aims to analyzing the relation between the work-related distress with the exposition to ionizing radiations in the radiology technicians, in the hospital environment. MATERIALS AND METHODS: Our present study has been conducted on a group of 36 sanitary technicians (14 women and 22 man, with an average age of 48±10,1 years) working in the Hospital Radiology Pavilion; 28 of them were less-exposed to radio-active emissions (B Category) and 8 were more exposed to radio-active emissions (A Category)...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27834086/what-proportion-of-patients-meet-the-criteria-for-uncomplicated-sepsis-in-an-irish-emergency-department
#12
C McNevin, R McDowell, F Fitzpatrick, P Gilligan, A Wakai
Emergency medicine plays a central role in the early recognition of patients presenting to hospital with sepsis. However, the epidemiology of sepsis in the Irish Emergency Department (ED) setting has not been described. The primary aim of this study was to determine the proportion of adult ED patients who meet the current criteria for uncomplicated sepsis. This cross-sectional study was performed in the ED of Beaumont Hospital, Dublin. The clinical records of all patients presenting to the ED over a four-week period were retrospectively screened to determine if they met the current Health Service Executive (HSE) criteria for uncomplicated sepsis...
August 8, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27830700/sensing-of-hsv-1-by-the-cgas-sting-pathway-in-microglia-orchestrates-antiviral-defence-in-the-cns
#13
Line S Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K Thomsen, Ramya Nandakumar, Trine H Mogensen, Morten Meyer, Christian Vægter, Jens R Nyengaard, Katherine A Fitzgerald, Søren R Paludan
Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression in CNS cells and these cytokines are induced in a cGAS-STING-dependent manner. Consistently, mice defective in cGAS or STING are highly susceptible to acute HSE. Although STING is redundant for cell-autonomous antiviral resistance in astrocytes and neurons, viral replication is strongly increased in neurons in STING-deficient mice...
November 10, 2016: Nature Communications
https://www.readbyqxmd.com/read/27827940/psychometric-properties-of-a-36-item-version-of-the-stress-management-competency-indicator-tool
#14
Stefano Toderi, Guido Sarchielli
The development of supervisors' behaviours has been proposed as an innovative approach for the reduction of employees' work stress. The UK Health and Safety Executive (HSE) developed the "Stress Management Competency Indicator Tool" (SMCIT), designed to be used within a learning and development intervention. However, its psychometric properties have never been evaluated, and the length of the questionnaire (66 items) limits its practical applicability. We developed a brief 36-item version of the questionnaire, assessed its psychometric properties and studied the relationship with the employees' psychosocial work environment...
November 7, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27826871/anti-n-methyl-d-aspartate-receptor-encephalitis-after-herpes-simplex-virus-associated-encephalitis-an-emerging-disease-with-diagnosis-and-therapeutic-challenges
#15
Flora Schein, Amandine Gagneux-Brunon, Jean-Christophe Antoine, Sylvie Lavernhe, Sylvie Pillet, Stéphane Paul, Anne Frésard, Claire Boutet, Rémi Grange, Céline Cazorla, Frédéric Lucht, Elisabeth Botelho-Nevers
INTRODUCTION: Morbidity and mortality of Herpes simplex virus encephalitis (HSE) remain high. Relapses of neurological signs may occur after initial clinical improvement under acyclovir treatment. METHODS: We report here a case of post-HSE anti-N-methyl-d-aspartate receptor-mediated encephalitis in an adult and perform a systematic search on PubMed to identify other cases in adults. RESULTS: We identified 11 previously published cases, to discuss diagnostic and therapeutic management...
November 8, 2016: Infection
https://www.readbyqxmd.com/read/27774355/herpes-simplex-encephalitis-of-the-parietal-lobe-a-rare-presentation
#16
Christian Fisahn, Lara Tkachenko, Marc Moisi, Steven Rostad, Randle Umeh, Michael E Zwillman, R Shane Tubbs, Jeni Page, David W Newell, Johnny B Delashaw
A 69-year-old female with a history of breast cancer and hypertension presented with a rare case of herpes simplex encephalitis (HSE) isolated to her left parietal lobe. The patient's first biopsy was negative for herpes simplex virus (HSV) I/II antigens, but less than two weeks later, the patient tested positive on repeat biopsy. This initial failure to detect the virus and the similarities between HSE and symptoms of intracranial hemorrhage (ICH) suggests repeat testing for HSV in the presence of ICH. Due to the frequency of patients with extra temporal HSE, a diagnosis of HSE should be more readily considered, particularly when a patient may not be improving and a concrete diagnosis has not been solidified...
September 16, 2016: Curēus
https://www.readbyqxmd.com/read/27717782/incidence-and-mortality-of-herpes-simplex-encephalitis-in-denmark-a-nationwide-registry-based-cohort-study
#17
Laura Krogh Jørgensen, Lars Skov Dalgaard, Lars Jørgen Østergaard, Mette Nørgaard, Trine Hyrup Mogensen
OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort. METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality...
October 4, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27711743/overview-of-the-crystal-chemistry-of-the-actinide-chalcogenides-incorporation-of-the-alkaline-earth-elements
#18
Adel Mesbah, Jai Prakash, James A Ibers
This review focuses on the results of exploratory syntheses of alkaline-earth-metal actinide chalcogenides Ak-An-Q (Ak = Ba, Sr; An = Th, U; Q = S, Se, and Te). About thirty new compounds are described. Although the basic building blocks of their structures are usually AnQ6 octahedra and AkQ8 bicapped trigonal prisms, these are combined in diverse ways to afford eleven new structure types. The structures reconfirm the prevailing presence of An(4+) in chalcogenides, although some of the compounds discovered are mixed An(4+)/An(5+) systems, and a few contain only An(5+)...
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27704844/predicting-band-gaps-with-hybrid-density-functionals
#19
Alejandro J Garza, Gustavo E Scuseria
We compare the ability of four popular hybrid density functionals (B3LYP, B3PW91, HSE, and PBE0) for predicting band gaps of semiconductors and insulators over a large benchmark set using a consistent methodology. We observe no significant statistical difference in their overall performance although the screened hybrid HSE is more accurate for typical semiconductors. HSE can improve its accuracy for large large band gap materials --without affecting that of semiconductors-- by including a larger portion of Hartree--Fock exchange in its short range...
October 5, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27698716/fulminant-bilateral-acute-retinal-necrosis-syndrome-associated-with-viral-encephalitis-a-case-report
#20
Chunkui Zhou, Lijun Zhu, Shaokuan Fang
Herpes simplex virus (HSV) is the most common cause of acute viral encephalitis. Acute retinal necrosis (ARN) is a rapidly progressing and potentially blinding eye disease that may be induced by HSV. The present case study reports the very rare case of a patient with herpes simplex encephalitis (HSE) combined with acute retinal necrosis (ARN). A 47-year-old woman was admitted to hospital with persistent high fever and somnolence for 5 days. Magnetic resonance imaging showed abnormal signals in the right medial temporal lobes, and HSV-1 was identified in the serum and cerebrospinal fluid...
October 2016: Experimental and Therapeutic Medicine
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