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https://www.readbyqxmd.com/read/28514720/new-application-for-haplotype-specific-extraction-separation-of-mitochondrial-dna-mixtures
#1
J Zander, J Rothe, J Dapprich, M Nagy
A particularly challenging aspect of forensic casework is the accurate interpretation of samples that contain DNA from more than one contributor, since DNA analysis of specific identification markers often results in ambiguous mixed profiles. Physically separating the various haploid components of a diploid or polyploid DNA sample or of a specimen containing DNA from multiple individuals can resolve this problem. We adapted and combined previously developed methods of haplotype-specific extraction (HSE) to separate and analyze mitochondrial DNA (mtDNA) in samples containing DNA from two individuals...
May 6, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28502175/london-dispersion-enables-the-shortest-intermolecular-hydrocarbon-h%C3%A2-%C3%A2-%C3%A2-h-contact
#2
Sören Rösel, Henrik Quanz, Christian Logemann, Jonathan Becker, Estelle Mossou, Laura Cañadillas-Delgado, Eike Caldeweyher, Stefan Grimme, Peter R Schreiner
Neutron diffraction of tri(3,5-tert-butylphenyl)-methane at 20 K reveals an intermolecular C-H···H-C distance of only 1.566(5) Å, which is the shortest reported to date. The compound crystallizes as a C3-symmetric dimer in an unusual head-to-head fashion. Quantum chemical computations of the solid state at the HSE-3c level of theory reproduce the structure and the close contact very well (1.555 Å at 0 K) and emphasize the significance of packing effects; the gas-phase dimer structure at the same level shows a 1...
May 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28497369/co-enzyme-q10-and-acetyl-salicylic-acid-enhance-hsp70-expression-in-primary-chicken-myocardial-cells-to-protect-the-cells-during-heat-stress
#3
Jiao Xu, Shu Tang, Bin Yin, Jiarui Sun, Erbao Song, Endong Bao
We investigated the effects of co-enzyme Q10 (Q10) and acetyl salicylic acid (ASA) on expression of Hsp70 in the protection of primary chicken myocardial cells during heat stress. Western blot analysis showed that Q10 and ASA accelerated the induction of Hsp70 when chicken myocardial cells were exposed to hyperthermia. In the absence of heat stress, however, neither Q10 nor ASA are able to upregulate Hsp70 expression. Analysis of enzymes that respond to cellular damage and pathological examination revealed that ectopic expression of ASA and Q10 alleviate cellular damage during heat stress...
May 11, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28474118/genome-wide-analysis-identifies-chickpea-cicer-arietinum-heat-stress-transcription-factors-hsfs-responsive-to-heat-stress-at-the-pod-development-stage
#4
Parameswaran Chidambaranathan, Prasanth Tej Kumar Jagannadham, Viswanathan Satheesh, Deshika Kohli, Santosh Halasabala Basavarajappa, Bharadwaj Chellapilla, Jitendra Kumar, Pradeep Kumar Jain, R Srinivasan
The heat stress transcription factors (Hsfs) play a prominent role in thermotolerance and eliciting the heat stress response in plants. Identification and expression analysis of Hsfs gene family members in chickpea would provide valuable information on heat stress responsive Hsfs. A genome-wide analysis of Hsfs gene family resulted in the identification of 22 Hsf genes in chickpea in both desi and kabuli genome. Phylogenetic analysis distinctly separated 12 A, 9 B, and 1 C class Hsfs, respectively. An analysis of cis-regulatory elements in the upstream region of the genes identified many stress responsive elements such as heat stress elements (HSE), abscisic acid responsive element (ABRE) etc...
May 4, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28471862/t-cell-responses-to-hsv-1-in-persons-who-have-survived-childhood-herpes-simplex-encephalitis
#5
Mariliis Ott, Lichen Jing, Lazaro Lorenzo, Jean-Laurent Casanova, Shen-Ying Zhang, David M Koelle
BACKGROUND: Herpes simplex encephalitis (HSE) after primary HSV-1 infection can occur in children due to inborn errors of cell-intrinsic immunity in the central nervous system (CNS). Paradoxically, symptomatic mucocutaneous HSV-1 recurrences are rare survivors of childhood HSE. T-cell acquired immunity is thought to be involved in control of recurrent mucocutaneous HSV infection. We thus tested HSV-1-specific immunity in HSE survivors. METHODS: We obtained serum and peripheral blood mononuclear cells (PBMC) a median of 13...
May 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28458823/herpes-simplex-virus-type-1-encephalitis-in-an-adolescent-presenting-with-acute-hydrocephalus
#6
Marios S Themistocleous, Elias Antoniades, Dimitrios Giakoumettis, Aristoteles V Kalyvas, Andreas Mitsios, George Sfakianos
Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly due to HSV-2 infection. HSV-1 infection of central nervous system present in the majority of the cases as encephalitis...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28450685/acyclovir-resistant-acute-herpes-simplex-encephalitis-associated-with-acute-retinal-necrosis-a-case-report-and-review-of-the-literature
#7
Haruchika Ogura, Jiro Fukae, Satoshi Kimura, Mikiko Aoki, Kazuki Nabeshima, Yoshio Tsuboi
A 55-year-old man was admitted to our hospital for investigation of high fever, decreased consciousness and bilateral visual impairment. His cerebrospinal fluid analysis revealed pleocytosis of mononuclear cells and an increased protein concentration. FLAIR images revealed multiple high-intensity lesions in the frontal lobe, part of which was enhanced with gadolinium. Despite initiating treatment with acyclovir and corticosteroids, his consciousness and visual acuity deteriorated. Immunopathological examination of brain biopsies showed numerous herpes simplex virus type 2-positive neurons and macrophages, leading to a diagnosis of herpes simplex encephalitis (HSE)...
April 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28445829/the-role-of-peu-mir164-and-its-target-penac-genes-in-response-to-abiotic-stress-in-populus-euphratica
#8
Xin Lu, Hui Dun, Conglong Lian, Xiaofei Zhang, Weilun Yin, Xinli Xia
Plant miR164 family is highly conserved and miR164 members regulate conserved targets belonging to NAC transcription factors. Our previous studies have revealed that peu-miR164a-e and its target gene POPTR_0007s08420 participate in abiotic stress response in Populus euphratica according to deep sequencing and degradome sequencing. In this study, miR164 family comprises six members that generate two mature products (miR164a-e and miR164f) and target seven NAC genes in P. euphratica. Co-expression in Nicotiana benthamiana and 5' RACE confirmed that peu-miR164 directs PeNAC070, PeNAC012 and PeNAC028 mRNAs cleavage...
April 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28439892/cerebrospinal-fluid-cyto-chemokine-profile-during-acute-herpes-simplex-virus-induced-anti-n-methyl-d-aspartate-receptor-encephalitis-and-in-chronic-neurological-sequelae
#9
Kavitha Kothur, Deepak Gill, Melanie Wong, Shekeeb S Mohammad, Sushil Bandodkar, Susan Arbunckle, Louise Wienholt, Russell C Dale
AIM: To examine the cytokine/chemokine profile of cerebrospinal fluid (CSF) during acute herpes simplex virus-induced N-methyl-d-aspartate receptor (NMDAR) autoimmunity and in chronic/relapsing post-herpes simplex virus encephalitis (HSE) neurological syndromes. METHOD: We measured longitudinal serial CSF cyto-/chemokines (n=34) and a glial marker (calcium-binding astroglial protein, S100B) in one patient during acute HSE and subsequent anti-NMDAR encephalitis, and compared the results with those from two patients with anti-NMDAR encephalitis without preceding HSE...
April 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28439890/herpes-simplex-virus-induced-anti-n-methyl-d-aspartate-receptor-encephalitis-a-systematic-literature-review-with-analysis-of-43-cases
#10
REVIEW
Margherita Nosadini, Shekeeb S Mohammad, Francesco Corazza, Ezia Maria Ruga, Kavitha Kothur, Giorgio Perilongo, Anna Chiara Frigo, Irene Toldo, Russell C Dale, Stefano Sartori
AIM: To conduct a systematic literature review on patients with biphasic disease with herpes simplex virus (HSV) encephalitis followed by anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHOD: We conducted a case report and systematic literature review (up to 10 December 2016), focused on differences between herpes simplex encephalitis (HSE) and anti-NMDAR encephalitis phases, age-related characteristics of HSV-induced anti-NMDAR encephalitis, and therapy...
April 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28415709/a-peptide-derived-from-apoptin-inhibits-glioma-growth
#11
Liqiu Zhang, Hengyu Zhao, Zhongqi Cui, Yueshan Lv, Wenjia Zhang, Xiaoyu Ma, Jianan Zhang, Banghao Sun, Danyang Zhou, Lijie Yuan
Glioblastoma (GBM) is associated with poor prognosis due to its resistance to surgery, irradiation, and conventional chemotherapy. Thus, efficient therapeutic approaches for the treatment of GBM are urgently needed. HSP70 is an antiapoptotic protein that participates in the inhibition of both mitochondrial and membrane receptor apoptosis pathways and is highly expressed in glioma tissues. Here, we investigated a derivative of apoptin; specifically, a chicken anemia viral protein with selective toxicity toward cancer cells that can inhibit hyperactive molecules, including HSP70...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28368532/tlr3-mutations-in-adult-patients-with-herpes-simplex-virus-and-varicella-zoster-virus-encephalitis
#12
Manuela Sironi, Anna Maria Peri, Rachele Cagliani, Diego Forni, Stefania Riva, Mara Biasin, Mario Clerici, Andrea Gori
Defects in genes of the TLR3 pathway are associated with susceptibility to HSV-1 encephalitis (HSE). We analyzed a cohort of 11 adult Italian patients who developed viral encephalitis. We detected two rare missense mutations in TLR3: one in a HSE patient (p.Leu297Val ) and the other in an individual with VZV encephalitis (p.Leu199Phe). Both mutations are extremely rare in human populations and have pathogenicity scores highly suggestive of a functional effect. Data herein expand the phenotypic spectrum of TLR3 mutations to VZV encephalitis and support the role of TLR3 genetic defects as risk factors for herpesvirus encephalitis in adults...
March 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28364664/contribution-of-neuroinflammation-to-changes-in-11-c-flumazenil-binding-in-the-rat-brain-evaluation-of-the-inflamed-pons-as-reference-tissue
#13
Andrea Parente, David Vállez García, Alexandre Shoji, Isadora Lopes Alves, Bram Maas, Rolf Zijlma, Rudi Ajo Dierckx, Carlos A Buchpiguel, Erik Fj de Vries, Janine Doorduin
INTRODUCTION: [(11)C]Flumazenil is a well-known PET tracer for GABAA receptors and is mainly used as an imaging biomarker for neuronal loss. Recently, GABAA receptors on immune cells have been investigated as target for modulation of inflammation. Since neuronal loss is often accompanied by neuroinflammation, PET imaging with [(11)C]flumazenil is potentially affected by infiltrating immune cells. This may also compromise the validity of using the pons as reference tissue in quantitative pharmacokinetic analysis...
June 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28355421/an-assessment-of-the-robustness-of-the-coshh-essentials-c-e-target-airborne-concentration-ranges-15-years-on-and-their-usefulness-for-determining-control-measures
#14
Nicholas P Vaughan, Rajadurai Rajan-Sithamparanadarajah
The Health and Safety Executive (HSE) in Great Britain (GB), in association with its stakeholders, developed the Control of Substances Hazardous to Health (COSHH)-Essentials (C-E) control banding tool in 1998. The objective was to provide a simple tool for employers, particularly small and medium-sized enterprises (SMEs), to help select and apply appropriate measures for the adequate control of exposure to hazardous substances. The tool used hazard classification information (R-phrases) to assign substances to one of five health hazard groups, each with its respective 'target airborne concentration range'...
February 21, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28345727/intrinsic-defects-and-their-effects-on-the-optical-properties-in-the-nonlinear-optical-crystal-cdsip2-a-first-principles-study
#15
Ci Wang, Jie Sun, Huiyang Gou, Shanpeng Wang, Jian Zhang, Xutang Tao
In view of their high nonlinear optical coefficients and good phase-matching properties, CdSiP2 (CSP) crystals are considered as one of the most promising materials in the field of nonlinear optical applications. However, the slight absorption losses around 1.34 μm and 1.78 μm under e-polarized light have been affecting its performance. In this study, first-principles calculations were performed to identify the effects of various charge defects on the absorption properties. Different intrinsic defects in the CSP crystal were calculated using the HSE method and compared according to the specific chemical environments in the experiments...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28331120/color-functionality-used-in-visual-display-for-occupational-and-environmental-safety-and-managing-color-vision-deficiency
#16
Nobuhisa Ochiai, Hiroyuki Kondo
The effects of color perception are utilized in visual displays for the purpose of safety in the workplace and in daily life. These effects, generally known as color functionality, are divided into four classifications: visibility, legibility, conspicuity and discriminability. This article focuses on the relationship between the color functionality of color schemes used in visual displays for occupational and environmental safety and color vision deficiency (particularly congenital red-green color deficiency), a critical issue in ophthalmology, and examines the effects of color functionality on the perception of the color red in individuals with protan defects...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28302316/defining-nervous-system-susceptibility-during-acute-and-latent-herpes-simplex-virus-1-infection
#17
REVIEW
Chandra M Menendez, Daniel J J Carr
Herpes simplex viruses are neurotropic human pathogens that infect and establish latency in peripheral sensory neurons of the host. Herpes Simplex Virus-1 (HSV-1) readily infects the facial mucosa that can result in the establishment of a latent infection in the sensory neurons of the trigeminal ganglia (TG). From latency, HSV-1 can reactivate and cause peripheral pathology following anterograde trafficking from sensory neurons. Under rare circumstances, HSV-1 can migrate into the central nervous system (CNS) and cause Herpes Simplex Encephalitis (HSE), a devastating disease of the CNS...
March 8, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28295305/mitochondrial-ros-induced-erk1-2-activation-and-hsf2-mediated-at1-r-upregulation-are-required-for-doxorubicin-induced-cardiotoxicity
#18
Chih-Yang Huang, Jia-Yi Chen, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho, Tung-Sheng Chen, Fu-Jen Tsai, Vijaya V Padma, Wei-Wen Kuo, Chih-Yang Huang
Doxorubicin (DOX), one useful chemotherapeutic agent, is limited in clinical use because of its serious cardiotoxicity. Growing evidence suggests that angiotensin receptor blockers (ARBs) have cardioprotective effects in DOX-induced cardiomyopathy. However, the detailed mechanisms underlying the action of ARBs on the prevention of DOX-induced cardiomyocyte cell death have yet to be investigated. Our results showed that angiotensin II receptor type I (AT1 R) plays a critical role in DOX-induced cardiomyocyte apoptosis...
March 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28285253/effect-of-self-esteem-on-social-interactions-during-the-ultimatum-game
#19
V Paz, E Nicolaisen-Sobesky, E Collado, S Horta, C Rey, M Rivero, P Berriolo, M Díaz, M Otón, A Pérez, G Fernández-Theoduloz, Á Cabana, V B Gradin
Self-esteem is an attitude formed by self-evaluation based on positive and negative aspects of oneself. Low self-esteem is a risk factor for psychiatric disorders and is especially associated with social difficulties. Recently, behavioral economics has allowed the quantitative study of social interactions. We investigated the association between self-esteem and interpersonal problems and whether self-esteem modulates behavior and emotions during an economic task, the Ultimatum Game (UG). In this task participants accept or reject fair/unfair monetary offers from others...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28278385/the-type-i-interferon-response-and-age-dependent-susceptibility-to-herpes-simplex-virus-infection
#20
Daniel Giraldo, Douglas R Wilcox, Richard Longnecker
Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection...
May 2017: DNA and Cell Biology
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