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https://www.readbyqxmd.com/read/28074766/-herpes-simplex-encephalitis
#1
Laura Krogh Jørgensen, Trine Hyrup Mogensen
Herpes simplex encephalitis (HSE) is a rare disease, although it is the most common form of sporadic encephalitis worldwide. Recently, studies have provided important new insight into the genetic and immunological basis of HSE. However, even in the presence of antiviral treatment, mortality and morbidity remain relatively high. Therefore, precise and early diagnosis together with basic and clinical studies to gain better insight into the pathogenesis of HSE is a prerequisite for the development of improved prophylaxis and treatment of this severe disease...
January 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28058442/%C3%AF-phosphorene-a-new-allotrope-of-phosphorene
#2
Haidi Wang, Xingxing Li, Zhao Liu, Jinlong Yang
Based on the crystal structure prediction, we propose a new allotrope of phosphorene, ψ-phosphorene (ψ-P), with a porous structure, which is both thermally and dynamically stable in comparison with the previously reported allotropes. Due to its unique atom configuration, ψ-P has highly orientation-dependent mechanical properties and excellent flexibility. Calculations using the HSE functional predict that ψ-P is semiconducting with an indirect band gap of 1.57 eV and possesses anisotropic transport properties...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28051827/job-stress-an-in-depth-investigation-based-on-the-hse-questionnaire-and-a-multistep-approach-in-order-to-identify-the-most-appropriate-corrective-actions
#3
S De Sio, F Cedrone, E Greco, M Di Traglia, D Sanità, D Mandolesi, S A Stansfeld
BACKGROUND: Psychosocial hazards and work-related stress have reached epidemic proportions in Europe. The Italia law introduced in 2008 the obligation for Italian companies to assess work related stress risk in order to protect their workers' safety and health. The purpose of our study was to propose an accurate measurement tool, using the HSE indicator tool, for more appropriate and significant work-related stress' prevention measures. METHODS: The study was conducted on 204 visual display unit (VDU) operators: 106 male and 98 female...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28045701/unexpected-heat-shock-element-binding-ability-and-tumor-killing-activity-of-the-combinatorial-function-domain-of-apoptin
#4
Liqiu Zhang, Jia Yang, Lu Liu, Wei Tian, Ming Gao, Weiwei Song, Hong Ling, Xingli Dong
Apoptin, derived from the chicken anemia virus, has been found to exert tumor-preferential apoptotic activity. It is a potential anticancer agent with direct clinical applications. However, if this viral protein were to be used as a new drug, it might also induce a strong immune response, causing toxic side effects. In a previous study, our group showed that TAT-apoptin downregulates the stress expression of heat shock protein 70 by competing with heat shock factor protein 1 in binding to the heat shock element (HSE) of the promoter region of heat shock protein 70, thus inducing specific apoptosis in HepG2 cells...
December 29, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28035614/health-safety-and-environmental-unit-performance-assessment-model-under-uncertainty-case-study-steel-industry
#5
Azin Shamaii, Manouchehr Omidvari, Farhad Hosseinzadeh Lotfi
Performance assessment is a critical objective of management systems. As a result of the non-deterministic and qualitative nature of performance indicators, assessments are likely to be influenced by evaluators' personal judgments. Furthermore, in developing countries, performance assessments by the Health, Safety and Environment (HSE) department are based solely on the number of accidents. A questionnaire is used to conduct the study in one of the largest steel production companies in Iran. With respect to health, safety, and environment, the results revealed that control of disease, fire hazards, and air pollution are of paramount importance, with coefficients of 0...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28028793/in-vitro-drug-transfer-due-to-drug-retention-in-human-epidermis-pretreated-with-application-of-marketed-estradiol-transdermal-systems
#6
Yellela S R Krishnaiah, Naresh Pavurala, Yang Yang, Prashanth Manda, Usha Katragadda, Yongsheng Yang, Rakhi Shah, Guodong Fang, Mansoor A Khan
Study objective was to assess skin-to-skin drug transfer potential that may occur due to drug retention in human epidermis (DRE) pretreated with application of estradiol transdermal drug delivery systems (TDDS) and other estradiol transdermal dosage forms (gels and sprays). TDDS (products-A, B, and C) with varying formulation design and composition, and other estradiol transdermal products (gel and spray) were applied to heat separated human epidermis (HSE) and subjected to in vitro drug permeation study. Amounts of DRE were quantified after 24 h...
December 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27930721/both-cerebral-and-hematopoietic-deficiencies-in-ccr2-result-in-uncontrolled-herpes-simplex-virus-infection-of-the-central-nervous-system-in-mice
#7
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress from the bone marrow (BM) and their trafficking into the central nervous system (CNS) in several neurological diseases. During experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE), CCR2 deficiency has been reported to exacerbate the outcome of the disease...
2016: PloS One
https://www.readbyqxmd.com/read/27919480/extratemporal-herpes-encephalitis-during-natalizumab-treatment-a-case-report
#8
Shalom Haggiag, Luca Prosperini, Simonetta Galgani, Carlo Pozzilli, Carmela Pinnetti
Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We report a MS patient under natalizumab treatment with HSE, who presented with MRI lesions exclusively in the right parietal lobe. The patient was timely started on acyclovir resulting in marked improvement...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27914480/mother-child-interactions-and-young-child-behavior-during-procedural-conscious-sedation
#9
Daniella Miranda-Remijo, Mara Rúbia Orsini, Patrícia Corrêa-Faria, Luciane Rezende Costa
BACKGROUND: As many preschoolers are not able to cooperate with health-related invasive procedures, sedation can help with the child's comfort and allow the intervention to be done. It is scarcely known how parents affect children's behavior during dental treatment under conscious sedation. The aim of this exploratory study was to analyze the association between mother-child interactions in day-to-day family life and preschool children's behavior during dental treatment under conscious sedation...
December 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27909291/engineering-of-a-thermostable-esterase-est816-to-improve-its-quorum-quenching-activity-and-the-underlying-structural-basis
#10
Xiwen Liu, Li-Chuang Cao, Xin-Jiong Fan, Yu-Huan Liu, Wei Xie
N-acyl-homoserine lactones (AHLs) are small diffusible molecules called autoinducers that mediate cell-to-cell communications. Enzymatic degradation of AHLs is a promising bio-control strategy known as quorum-quenching. To improve the quorum-quenching activity of a thermostable esterase Est816, which had been previously cloned, we have engineered the enzyme by random mutagenesis. One of the mutants M2 with double amino acid substitutions (A216V/K238N) showed 3-fold improvement on catalytic efficiency. Based on the crystal structure determined at 2...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909158/off-site-emergency-planning-at-uk-nuclear-licensed-sites
#11
Paul Leonard, Gareth Thomas
Nuclear emergency planning arrangements in the UK are continually kept under review. This work proposes to outline how experience from nuclear exercises and undertaking emergency response duties can be based on radiological knowledge of specific sites and utilised in the future. In 2014, the UK regulator, the Office for Nuclear Regulation (ONR) revised their principles for the determination of off-site emergency planning areas around nuclear sites where predetermined countermeasures and other protection measures are applied to protect those people who may be affected by a radiation emergency...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27902351/protective-role-of-cx3cr1-signaling-in-resident-cells-of-the-central-nervous-system-during-experimental-herpes-simplex-virus-encephalitis
#12
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin
CX3CR1 is an important chemokine receptor expressed on the surface of microglia and blood leukocytes including monocytes. Signaling through this receptor influences the immune activity of microglia and monocytes trafficking into the central nervous system (CNS) in several neurological diseases. During experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE), CX3CR1 deficiency has been reported to exacerbate the outcome of the disease. However, the precise contribution of CX3CR1 expressed in resident cells of the CNS or peripheral monocytes in protection against HSE remains unclear...
November 30, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27879667/biological-chemistry-of-hydrogen-selenide
#13
REVIEW
Kellye A Cupp-Sutton, Michael T Ashby
There are no two main-group elements that exhibit more similar physical and chemical properties than sulfur and selenium. Nonetheless, Nature has deemed both essential for life and has found a way to exploit the subtle unique properties of selenium to include it in biochemistry despite its congener sulfur being 10,000 times more abundant. Selenium is more easily oxidized and it is kinetically more labile, so all selenium compounds could be considered to be "Reactive Selenium Compounds" relative to their sulfur analogues...
November 22, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27875994/do-primary-care-professionals-agree-about-progress-with-implementation-of-primary-care-teams-results-from-a-cross-sectional-study
#14
E Tierney, M O'Sullivan, L Hickey, A Hannigan, C May, W Cullen, N Kennedy, L Kineen, A MacFarlane
BACKGROUND: Primary care is the cornerstone of healthcare reform with policies across jurisdictions promoting interdisciplinary team working. The effective implementation of such health policies requires understanding the perspectives of all actors. However, there is a lack of research about health professionals' views of this process. This study compares Primary Healthcare Professionals' perceptions of the effectiveness of the Primary Care Strategy and Primary Care Team (PCT) implementation in Ireland...
November 22, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27871327/ebola-zika-and-the-international-health-regulations-implications-for-port-health-preparedness
#15
R W Glynn, M Boland
BACKGROUND: The outbreak of Ebola Virus Disease in West Africa in 2014-2015 was unprecedented in terms of its scale and consequence.  This, together with the emergence of Zika virus as a Public Health Emergency of International Concern in 2016, has again highlighted the potential for disease to spread across international borders and provided an impetus for countries to review their Port Health preparedness. This report reviews the legislative framework and actions taken under this framework in advancing and improving Port Health preparedness in Ireland, in response to the declaration of the Public Health Emergency of International Concern for Ebola Virus Disease in August 2014...
November 21, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27866167/rewiring-of-signaling-networks-modulating-thermotolerance-in-the-human-pathogen-cryptococcus-neoformans
#16
Dong-Hoon Yang, Kwang-Woo Jung, Soohyun Bang, Jang-Won Lee, Min-Hee Song, Anna Floyd-Averette, Richard A Festa, Giuseppe Ianiri, Alexander Idnurm, Dennis J Thiele, Joseph Heitman, Yong-Sun Bahn
Thermotolerance is a crucial virulence attribute for human pathogens, including the fungus Cryptococcus neoformans that causes fatal meningitis in humans. Loss of the protein kinase Sch9 increases C. neoformans thermotolerance, but its regulatory mechanism has remained unknown. Here, we studied the Sch9-dependent and Sch9-independent signaling networks modulating C. neoformans thermotolerance by using genome-wide transcriptome analysis and reverse genetic approaches. During temperature upshift, genes encoding for molecular chaperones and heat shock proteins were upregulated, whereas those for translation, transcription, and sterol biosynthesis were highly suppressed...
January 2017: Genetics
https://www.readbyqxmd.com/read/27862521/design-of-an-optimal-promoter-involved-in-the-heat-induced-transcriptional-pathway-in-arabidopsis-soybean-rice-and-maize
#17
Kyonoshin Maruyama, Takuya Ogata, Norihito Kanamori, Kyouko Yoshiwara, Shingo Goto, Yoshiharu Y Yamamoto, Yuko Tokoro, Chihiro Noda, Yuta Takaki, Hiroko Urawa, Satoshi Iuchi, Kaoru Urano, Takuhiro Yoshida, Tetsuya Sakurai, Mikiko Kojima, Hitoshi Sakakibara, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Interactions between heat shock factor (HSF) and the heat shock response element (HSE) are important during the heat shock response (HSR) of flora and fauna. Moreover, plant HSFs that are involved in heat stress are also involved in abiotic stresses such as dehydration and cold as well as development, cell differentiation, and proliferation. Because the specific combination of HSFs and HSEs involved in plants under heat stress remains unclear, the mechanism of their interaction has not yet been utilized in plant molecular breeding for climate change...
November 15, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27845493/ionizing-radiation-and-stress-the-analysis-of-the-medical-ray-technician
#18
S De Sio, D Mandolesi, V Colasanti, C Goglia, S Cuzzola, M Di Traglia, E Greco
BACKGROUND: The present study aims to analyzing the relation between the work-related distress with the exposition to ionizing radiations in the radiology technicians, in the hospital environment. MATERIALS AND METHODS: Our present study has been conducted on a group of 36 sanitary technicians (14 women and 22 man, with an average age of 48±10,1 years) working in the Hospital Radiology Pavilion; 28 of them were less-exposed to radio-active emissions (B Category) and 8 were more exposed to radio-active emissions (A Category)...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27834086/what-proportion-of-patients-meet-the-criteria-for-uncomplicated-sepsis-in-an-irish-emergency-department
#19
C McNevin, R McDowell, F Fitzpatrick, P Gilligan, A Wakai
Emergency medicine plays a central role in the early recognition of patients presenting to hospital with sepsis. However, the epidemiology of sepsis in the Irish Emergency Department (ED) setting has not been described. The primary aim of this study was to determine the proportion of adult ED patients who meet the current criteria for uncomplicated sepsis. This cross-sectional study was performed in the ED of Beaumont Hospital, Dublin. The clinical records of all patients presenting to the ED over a four-week period were retrospectively screened to determine if they met the current Health Service Executive (HSE) criteria for uncomplicated sepsis...
August 8, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27830700/sensing-of-hsv-1-by-the-cgas-sting-pathway-in-microglia-orchestrates-antiviral-defence-in-the-cns
#20
Line S Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K Thomsen, Ramya Nandakumar, Trine H Mogensen, Morten Meyer, Christian Vægter, Jens R Nyengaard, Katherine A Fitzgerald, Søren R Paludan
Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression in CNS cells and these cytokines are induced in a cGAS-STING-dependent manner. Consistently, mice defective in cGAS or STING are highly susceptible to acute HSE. Although STING is redundant for cell-autonomous antiviral resistance in astrocytes and neurons, viral replication is strongly increased in neurons in STING-deficient mice...
November 10, 2016: Nature Communications
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