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https://www.readbyqxmd.com/read/28535578/coasting-withholding-gonadotrophins-for-preventing-ovarian-hyperstimulation-syndrome
#1
REVIEW
Arianna D'Angelo, Nazar N Amso, Rudaina Hassan
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence of moderate to severe OHSS ranges from 0.6% to 5% of in vitro fertilization (IVF) cycles. The factors contributing to OHSS have not been completely explained. The release of vasoactive substances secreted by the ovaries under human chorionic gonadotrophin (hCG) stimulation may play a key role in triggering this syndrome...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28535425/prenatal-ambient-air-pollution-exposure-infant-growth-and-placental-mitochondrial-dna-content-in-the-inma-birth-cohort
#2
Diana B P Clemente, Maribel Casas, Bram G Janssen, Aitana Lertxundi, Loreto Santa-Marina, Carmen Iñiguez, Sabrina Llop, Jordi Sunyer, Mònica Guxens, Tim S Nawrot, Martine Vrijheid
BACKGROUND: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association. OBJECTIVE: In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO2) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association...
May 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28535404/placental-inflammation-and-its-relationship-to-cervicovaginal-fetal-fibronectin-in-preterm-birth
#3
Laura van der Krogt, Alexandra E Ridout, Paul T Seed, Andrew H Shennan
OBJECTIVE: Late miscarriage and preterm birth are frequently thought to be associated with inflammation and infection, although in most cases the underlying cause of early delivery remains unknown. The placenta is the organ that links mother and fetus during pregnancy, and postnatal examination may provide useful information about pathophysiology. The relationship between placental pathological lesions and predictive markers of early delivery has not been explored. We sought to characterize preterm deliveries according to placental pathology and relate these to the performance of reliable predictive markers, fetal fibronectin and cervical length...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28535392/nervous-system-development-temporal-patterning-of-large-neural-lineages
#4
Stefan Thor
Neural progenitor cells in most, if not all, systems generate different cell types according to a fixed birth-order. Studies in the Drosophila central nervous system now identify an expanding regulatory network underlying temporal diversification of very large neural lineages.
May 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28535184/maternal-zika-virus-disease-severity-virus-load-prior-dengue-antibodies-and-their-relationship-to-birth-outcomes
#5
U A Halai, K Nielsen-Saines, M E Moreira, P C Sequeira, J P Pereira Junior, A A Zin, J D Cherry, C R Gabaglia, S L Gaw, K Adachi, I Tsui, J H Pilotto, R M Ribeiro Nogueira, A M Bispo de Filippis, P Brasil
Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection...
May 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28535175/parental-age-and-risk-of-pediatric-cancer-in-the-offspring-a-population-based-record-linkage-study-in-california
#6
Rong Wang, Catherine Metayer, Libby Morimoto, Joseph L Wiemels, Andrew T DeWan, Alice Kang, Xiaomei Ma
By linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born in 1978-2009 to investigate the relation of parental age to risk of pediatric cancer. Compared to children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13% to 36% increased risk of pediatric cancer, the odds ratio (OR) for each 5-year maternal age increase was 1.06 (95% confidence interval[CI]: 1.04,1.09). For cancer diagnosed at 0-14 and 15-19 years, the OR for each 5-year increase in maternal age was1...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535165/parental-body-mass-index-and-behavioral-problems-in-their-offspring-a-danish-national-birth-cohort-study
#7
Susanne Hvolgaard Mikkelsen, Lena Hohwü, Jørn Olsen, Bodil Hammer Bech, Zeyan Liew, Carsten Obel
Maternal obesity has been associated with increased risk of offspring behavioral problems. We examined whether this association could be explained by familial factors by comparing associations for maternal body mass index (BMI) with associations for paternal BMI. We studied 38,314 children born to mothers enrolled in the Danish National Birth Cohort during 1996-2002. Data on maternal BMI was collected at 15 weeks of gestation, and paternal BMI was assessed when the child was 18 months old. When the child was 7 years old, the Strengths and Difficulties Questionnaire was completed by the parents...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535129/suicide-and-mental-disorders-a-discourse-of-politics-power-and-vested-interests
#8
Heidi Hjelmeland, Birthe L Knizek
One of the most well-established "truths" in suicidology is that mental disorders play a significant role in at least 90% of suicides, and a causal relationship between the two is often implied. In this essay, we argue that the evidence base for this "truth" is weak and that there is much research questioning the 90% statistic. Based on numerous examples, we also argue that ideology, politics, power, and vested interests among influential professionals in the field obstruct argument-based discussion of this issue...
May 23, 2017: Death Studies
https://www.readbyqxmd.com/read/28534929/teratogens-a-public-health-issue-a-brazilian-overview
#9
Thiago Mazzu-Nascimento, Débora Gusmão Melo, Giorgio Gianini Morbioli, Emanuel Carrilho, Fernanda Sales Luiz Vianna, André Anjos da Silva, Lavinia Schuler-Faccini
Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects - or teratogens - as a public health issue and present their mechanisms of action, categories and their respective maternal-fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of 2,175), and the average cost of hospitalizations (annual cost of $7,758)...
May 22, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28534927/genome-wide-association-study-for-birth-weaning-and-yearling-weight-in-colombian-brahman-cattle
#10
Rodrigo Martínez, Diego Bejarano, Yolanda Gómez, Romain Dasoneville, Ariel Jiménez, Gael Even, Johann Sölkner, Gabor Mészáros
Genotypic and phenotypic data of 1,562 animals were analyzed to find genomic regions that potentially influence the birth weight (BW), weaning weight at seven months of age (WW) and yearling weight (YW) of Colombian Brahman cattle, with genotyping conducted using Illumina Bead chip array with 74,669 SNPs. A Single Step Genomic BLUP (ssGBLP), approach was used to estimate the proportion of variance explained by each marker. Multiple regions scattered across the genome were found to influence weights at different ages, also dependent on the trait component (direct or maternal)...
May 22, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28534840/birth-outcomes-after-the-fukushima-daiichi-nuclear-power-plant-disaster-a-long-term-retrospective-study
#11
Claire Leppold, Shuhei Nomura, Toyoaki Sawano, Akihiko Ozaki, Masaharu Tsubokura, Sarah Hill, Yukio Kanazawa, Hiroshi Anbe
Changes in population birth outcomes, including increases in low birthweight or preterm births, have been documented after natural and manmade disasters. However, information is limited following the 2011 Fukushima Daiichi Nuclear Power Plant Disaster. In this study, we assessed whether there were long-term changes in birth outcomes post-disaster, compared to pre-disaster data, and whether residential area and food purchasing patterns, as proxy measurements of evacuation and radiation-related anxiety, were associated with post-disaster birth outcomes...
May 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28534761/to-see-anew-new-technologies-are-moving-rapidly-toward-restoring-or-enabling-vision-in-the-blind
#12
Kristina Grifantini
Humans have been using technology to improve their vision for many decades. Eyeglasses, contact lenses, and, more recently, laser-based surgeries are commonly employed to remedy vision problems, both minor and major. But options are far fewer for those who have not seen since birth or who have reached stages of blindness in later life.
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28534726/evaluation-of-longevity-modeling-censored-records-in-nellore
#13
D A Garcia, G J M Rosa, B D Valente, R Carvalheiro, G A Fernandes Júnior, L G Albuquerque
The aim of the present study was to evaluate the prediction ability of models that cope with longevity phenotypic expression as uncensored and censored in Nellore cattle. Longevity was defined as the difference between the dates of last weaned calf and cow birth. There were information of 77 353 females, being 61 097 cows with uncensored phenotypic information and 16 256 cows with censored records. These data were analyzed considering three different models: (1) Gaussian linear model (LM), in which only uncensored records were considered; and two models that consider both uncensored and censored records: (2) Censored Gaussian linear model (CLM); and (3) Weibull frailty hazard model (WM)...
May 23, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28534724/maternal-protein-restriction-depresses-the-duodenal-expression-of-iron-transporters-and-serum-iron-level-in-male-weaning-piglets
#14
Wenqiang Ma, Jingyu Lu, Shuxia Jiang, Demin Cai, Shifeng Pan, Yimin Jia, Ruqian Zhao
To investigate the effects of maternal dietary protein restriction on offspring Fe metabolism, twenty-four second-parity Landrace×Yorkshire sows were randomly allocated to standard-protein (SP) and low-protein (LP) groups. The SP sows were fed diets containing 15 and 18 % crude protein throughout pregnancy and lactation, respectively, whereas the LP sows were subjected to 50 % dietary protein restriction. Offspring birth weight was not affected, but the body weight at weaning (P=0·06) and average daily gain (P=0·01) of the female piglets were significantly decreased...
April 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28534656/early-development-in-rett-syndrome-the-benefits-and-difficulties-of-a-birth-cohort-approach
#15
Peter B Marschik, Sanne Lemcke, Christa Einspieler, Dajie Zhang, Sven Bölte, Gillian S Townend, Marlene B Lauritsen
PURPOSES: Typically, early (pre-diagnostic) development in individuals later diagnosed with Rett syndrome (RTT) has been investigated retrospectively using parent reports, medical records and analysis of home videos. In recent years, prospective research designs have been increasingly applied to the investigation of early development in individuals with late phenotypical onset disorders, for example, autism spectrum disorder. METHODS: In this study, data collected by the Danish National Birth Cohort lent itself to prospective exploration of the early development of RTT, in particular early motor-, speech-language, and socio-communicative behaviors, mood, and sleep...
May 23, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28534605/diastematomyelia-and-late-onset-presentation-a-case-report-of-a-72-year-old-woman
#16
Hanne Maebe, Annick Viaene, Martine DE Muynck
BACKGROUND: We would like to present the case of a 72-year-old woman, in whom diastematomyelia was surprisingly discovered when looking for an explanation for her neurological and urological complaints. Diastematomyelia is a rare disease in the group of 'spinal dysraphisms', mostly discovered at birth and very rare at advanced age. The clinical pattern could be seen in the general presentation of 'tethered cord' and there are 2 types of presentation with a different treatment. CASE REPORT: In our case report the two dominant complaints were pain in the right foot and sphincter problems...
May 23, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28534597/metabolomics-for-improving-pregnancy-outcomes-in-women-undergoing-assisted-reproductive-technologies
#17
REVIEW
Charalampos S Siristatidis, Eleni Sertedaki, Dennis Vaidakis
BACKGROUND: In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, and facilitate a targeted subfertility treatment. OBJECTIVES: To evaluate the effectiveness and safety of metabolomic assessment of oocyte quality, embryo viability, and endometrial receptivity for improving live birth or ongoing pregnancy rates in women undergoing ART, compared to conventional methods of assessment...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28534458/association-between-dietary-patterns-and-adiposity-from-4-to-7-years-of-age
#18
Catarina Durão, Milton Severo, Andreia Oliveira, Pedro Moreira, António Guerra, Henrique Barros, Carla Lopes
OBJECTIVE: The present study aimed to evaluate the association of 4-year-old children's dietary patterns with adiposity at 7 years, according to child's sex, using a conceptual model. DESIGN: Prospective cohort study. Diet was assessed using an FFQ. Age- and sex-specific BMI standard deviation scores (Z-scores) were defined according to the WHO. Fat mass percentage (FM%), fat mass index (FMI) and waist-to-height ratio (WHtR) were also considered, converted into Z-scores using sex-specific means and standard deviations of the current sample...
May 23, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28534456/effects-of-folic-acid-fortification-on-orofacial-clefts-prevalence-a-meta-analysis
#19
Natalia Millacura, Rosa Pardo, Lucia Cifuentes, José Suazo
OBJECTIVE: Orofacial clefts (OFC) are the most prevalent craniofacial birth defect. Folic acid (FA) supplementation has been demonstrated as an effective intervention to reduce risk of OFC occurrence. However, the effect of mandatory FA fortification of wheat and/or maize flour on OFC prevalence has shown controversial results among countries adopting this policy. Thus, we performed a meta-analysis to synthesize the available evidence evaluating the global impact of this mandatory policy on OFC occurrence...
May 23, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28534447/selenium-selenoproteins-and-selenometabolites-in-mothers-and-babies-at-the-time-of-birth
#20
Cristina Santos, Eduardo García-Fuentes, Belén Callejón-Leblic, Tamara García-Barrera, José Luis Gómez-Ariza, Margaret P Rayman, Inés Velasco
The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC...
May 23, 2017: British Journal of Nutrition
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