Madalina Icriverzi, Paula Ecaterina Florian, Anca Bonciu, Luminita Nicoleta Dumitrescu, Antoniu Moldovan, Diana Pelinescu, Robertina Ionescu, Ionela Avram, Cristian V A Munteanu, Livia Elena Sima, Valentina Dinca, Laurentiu Rusen, Anca Roseanu
In this study, hybrid bio-nanoporous peptides loaded onto poly( N -isopropylacrylamide- co -butylacrylate) (pNIPAM- co -BA) coatings were designed and obtained via matrix-assisted pulsed laser evaporation (MAPLE) technique. The incorporation of cationic peptides magainin (MG) and melittin (Mel) and their combination was tailored to target synergistic anticancer and antibacterial activities with low toxicity on normal mammalian cells. Atomic force microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy as well as contact angle and surface energy measurements revealed the successful and functional incorporation of both the peptides within porous polymeric nanolayers as well as surface modifications ( i...
April 16, 2024: Nanoscale advances