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Salvatore Chirumbolo, Geir Bjørklund
Marzotto et al. showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1 (THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4 (IL-4). A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A...
July 2017: Journal of Integrative Medicine
M L Hahnemann, A Dechene, S Kathemann, S Sirin, G Gerken, T C Lauenstein, S Kinner
AIM: To evaluate diffusion-weighted imaging (DWI) compared to standard magnetic resonance imaging (sMRI) in the assessment of inflammatory lesions of the small bowel. MATERIALS AND METHODS: Two readers retrospectively analysed MRI images of the small bowel including DWI followed by capsule endoscopy (CE) and ileocolonoscopy (ICS) in 30 consecutive patients with a suspected or established diagnosis of inflammatory bowel disease. Small bowel CE and the combination of CE + ICS were used as the standards of reference...
January 2017: Clinical Radiology
Silvia Waisse, Leoni Villano Bonamin
Facing claims for and against the scientific status of homeopathy, one is entitled to ask: is there a scientific model for homeopathy? In this study we reconstructed the model put forward by Hahnemann. The results showed that it was essentially based on the assumption of a 'vital force' exclusive to living beings. While the vital force was a basic element of 18th-century science, the existence of such a sui generis force of nature was refuted with the formulation of the law of the conservation of energy by mid-19th century...
August 2016: Homeopathy: the Journal of the Faculty of Homeopathy
Conrado Mariano Tarcitano, Silvia Waisse
Homeopathy began to spread soon after it was formulated by Samuel Hahnemann in the early 1800s, reaching the Southern Cone in the 1830s. In processes of this kind, one figure is often cited as being responsible for introducing it, often attaining quasi-mythical status. Little is known, however, about how homeopathy reached Argentina at that time. Through archival research, we discovered that medical and lay homeopaths circulated between Rio de Janeiro and Buenos Aires. Given the well-known proselytizing of the circles gravitating around lay homeopaths B...
July 2016: História, Ciências, Saúde—Manguinhos
Simone Kreher, Melanie Schlott, Thilo Schlott
As part of the research project, developments in the history of science and in the regional and ecclesiastic history of the late feudal petty state of Köthen-Anhalt have been assessed and numerous documents of the Nagel and Mühlenbein family histories examined that place the transcribed patient letters of the two Protestant clergymen within the context of the Hahnemann Archives. These findings complement and extend previous insights into Hahnemann's Köthen clientele, especially when it comes to the structure and milieu of the local clerical elite...
2016: Medizin, Gesellschaft, und Geschichte
Mads Bak, Susanne E Boonen, Christina Dahl, Johanne M D Hahnemann, Deborah J D G Mackay, Zeynep Tümer, Karen Grønskov, I Karen Temple, Per Guldberg, Niels Tommerup
BACKGROUND: Transient neonatal diabetes mellitus 1 (TNDM1) is a rare imprinting disorder characterized by intrautering growth retardation and diabetes mellitus usually presenting within the first six weeks of life and resolves by the age of 18 months. However, patients have an increased risk of developing diabetes mellitus type 2 later in life. Transient neonatal diabetes mellitus 1 is caused by overexpression of the maternally imprinted genes PLAGL1 and HYMAI on chromosome 6q24. One of the mechanisms leading to overexpression of the locus is hypomethylation of the maternal allele of PLAGL1 and HYMAI...
April 14, 2016: BMC Medical Genetics
Maria L Hahnemann, Oliver Kraff, Stefan Maderwald, Soeren Johst, Stephan Orzada, Lale Umutlu, Mark E Ladd, Harald H Quick, Thomas C Lauenstein
OBJECTIVE: To perform non-enhanced (NE) magnetic resonance imaging (MRI) of the small bowel at 7 Tesla (7T) and to compare it with 1.5 Tesla (1.5T). MATERIAL AND METHODS: Twelve healthy subjects were prospectively examined using a 1.5T and 7T MRI system. Coronal and axial true fast imaging with steady-state precession (TrueFISP) imaging and a coronal T2-weighted (T2w) half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequence were acquired. Image analysis was performed by 1) visual evaluation of tissue contrast and detail detectability, 2) measurement and calculation of contrast ratios and 3) assessment of artifacts...
June 2016: Magnetic Resonance Imaging
Jens Köhler, Martin Schuler, Thomas Christoph Gauler, Stefanie Nöpel-Dünnebacke, Maike Ahrens, Andreas-Claudius Hoffmann, Stefan Kasper, Felix Nensa, Benedikt Gomez, Maria Hahnemann, Frank Breitenbuecher, Danjouma Cheufou, Filiz Özkan, Kaid Darwiche, Mathias Hoiczyk, Henning Reis, Stefan Welter, Wilfried Ernst Erich Eberhardt, Martin Eisenacher, Helmut Teschler, Georgios Stamatis, Wolff Schmiegel, Stephan Albrecht Hahn, Alexander Baraniskin
PURPOSE: Lung cancer accounts for one in five cancer deaths. Broad screening strategies for high-risk populations are unavailable, and the validation of biomarkers for early cancer detection remains a prime interest. Therefore, we investigated the value of circulating U2 small nuclear RNA fragments (RNU2-1f) as a biomarker for diagnosis, prognosis estimation and treatment monitoring in a large lung cancer cohort. METHODS: We determined RNU2-1f abundance in sera of patients with treatment-naive lung cancer (n = 211, 25...
April 2016: Journal of Cancer Research and Clinical Oncology
Florian G Mildenberger
The dispute over low and high potencies is no longer current in today's homeopathy, but from the 1830s to the 1960s it played a major role in scientific discourse. The devotees of high potencies claimed to be the only true Hahnemannians, while their antagonists tried to practise a scientific, modernized homeopathy. The former ultimately triumphed in Britain, the U.S. and Germany, but this happened on quite different routes in each of these countries. As well as Hahnemann, other scholars, such as Constantin Hering, James T...
2015: Medizin, Gesellschaft, und Geschichte
M L Hahnemann, D Wittschieber, P Becker
No abstract text is available yet for this article.
January 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
(no author information available yet)
Studies have shown that patients who present to the ED with violence-related injuries are at high risk of being involved in future violent incidents. Consequently, investigators say the ED is an ideal setting to intervene with these individuals with the kind of care and support that will lead them toward a safer path. Helping Hurt People (HHP), a hospital-based trauma support program developed at Drexel University in Philadelphia, PA, has been fulfilling this function at Hahnemann University Hospital and St...
June 2015: ED Management: the Monthly Update on Emergency Department Management
Maria L Hahnemann, Oliver Kraff, Stephan Orzada, Lale Umutlu, Sonja Kinner, Mark E Ladd, Harald H Quick, Thomas C Lauenstein
OBJECTIVES: T1-weighted (T1w) contrast-enhanced magnetic resonance imaging (MRI) of the small bowel at 1.5 T magnetic field strength has become a standard technique in investigating diseases of the small bowel. High-field MRI potentially offers improved soft tissue contrast and spatial resolution, providing increased image detail. The purpose of this study was to evaluate the feasibility of contrast-enhanced small bowel MRI at 7 T and to compare results with 1.5 T. MATERIALS AND METHODS: Twelve healthy volunteers underwent small bowel MRI on a 1...
August 2015: Investigative Radiology
Mark Dzietko, Maria Hahnemann, Oliver Polley, Marco Sifringer, Ursula Felderhoff-Mueser, Christoph Bührer
Perinatal infections have a negative impact on brain development. However, the underlying mechanisms leading to neurological impairment are not completely understood and reliable models of inflammation are urgently needed. Using phorbol-myristate-acetate as an activator of inflammation, we investigated the effect on the developing rodent brain. Neonatal rats and mice deficient in IL-18 or IRAK-4 were exposed to PMA. Brains were assessed for regulation of pro- and anti-inflammatory cytokines and cell death 24 hrs, 7 and 14 days after treatment...
2015: BioMed Research International
M L Hahnemann, F Nensa, S Kinner, J Köhler, G Gerken, L Umutlu, T C Lauenstein
BACKGROUND: Assessment of motility alterations by functional magnetic resonance imaging (MRI) contributes to improved evaluation of inflammatory bowel disease. The aim of the study was to quantify motility in inflammatory bowel segments and to compare motility alterations with MR-based parameters for activity of inflammation in Crohn's disease (CD). METHODS: Thirty consecutive patients with CD underwent bowel MRI which included a dynamic sequence for automatic generation of parametric maps facilitating quantification of bowel motility...
June 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
S Kinner, M L Hahnemann, M Forsting, T C Lauenstein
Magnetic resonance imaging of the small bowel has been feasible for more than 15 years. This review is meant to give an overview of typical techniques, sequences and indications. Furthermore, newly evaluated promising techniques are presented, which have an impact on the advance of MR imaging of the small and large bowel.
March 2015: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Maria L Hahnemann, Sonja Kinner, Bernd Schweiger, Thomas Bajanowski, Bernd Karger, Heidi Pfeiffer, Daniel Wittschieber
OBJECTIVES: Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. METHODS: From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively...
February 2015: European Radiology
Maria L Hahnemann, Felix Nensa, Sonja Kinner, Stefan Maderwald, Lale Umutlu, Guido Gerken, Thomas C Lauenstein
OBJECTIVES: The objective of this study was to evaluate whether the use of automatically generated maps of bowel motility (motility mapping) in magnetic resonance imaging (MRI) leads to an increased detection rate of inflammatory bowel disease. MATERIALS AND METHODS: Fifty consecutive patients with suspected or known inflammatory bowel disease who underwent bowel MRI using a 1.5-T scanner were analyzed retrospectively. In addition to standard small bowel magnetic resonance protocol, a dynamic coronal T2-weighted sequence (dynamic MRI) was acquired...
February 2015: Investigative Radiology
Selma Sirin, Simone Kathemann, Bernd Schweiger, Maria L Hahnemann, Michael Forsting, Thomas C Lauenstein, Sonja Kinner
OBJECTIVES: Magnetic resonance colonography (MRC) is a well-accepted, noninvasive imaging modality for the depiction of inflammatory bowel disease. Diffusion-weighted imaging (DWI) is very helpful to display inflammatory lesions. The aim of this retrospective study was to assess whether intravenous contrast is needed to depict inflammatory lesions in bowel magnetic resonance imaging if DWI is available. MATERIALS AND METHODS: Thirty-seven patients (23 females, 14 males; mean age, 14...
January 2015: Investigative Radiology
D Wittschieber, B Karger, T Niederstadt, H Pfeiffer, M L Hahnemann
Are subdural hygromas the result of abusive head trauma? CT and MR imaging represent important tools for the diagnosis of abusive head trauma in living infants. In addition, in-depth understanding of the pathogenesis of subdural hygromas is increasingly required by neuroradiologists, pediatricians, and forensic physicians. Therefore, the current knowledge on subdural hygromas is summarized and forensic conclusions are drawn. The most important diagnostic pitfalls, benign enlargement of the subarachnoid space, and chronic subdural hematoma, are discussed in detail...
March 2015: AJNR. American Journal of Neuroradiology
Robert Jütte
Samuel Hahnemann (1755-1843) known today as the founder of homoeopathy, was - as far as we know - the first physician who administrated placebos to his patient on a systematic and regular basis. This study is based upon unpublished documents (e.g. patients' letters) in the Archives of the Institute for the History of Medicine of the Robert Bosch Foundation in Stuttgart. It also profited from the critical edition of Hahnemann's case journals and the editorial comments which have also been published in this series...
July 2014: Homeopathy: the Journal of the Faculty of Homeopathy
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