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Thoracic oncology

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https://www.readbyqxmd.com/read/29904738/implications-for-high-precision-dose-radiation-therapy-planning-or-limited-surgical-resection-after-percutaneous-computed-tomography-guided-lung-nodule-biopsy-using-a-tract-sealant
#1
Patricia M de Groot, Girish S Shroff, Judy Ahrar, Bradley S Sabloff, Garret M Gladish, Cesar Moran, Sanjay Gupta, Gregory W Gladish, Joe Y Chang, Jeremy J Erasmus
Purpose: Precision radiation therapy such as stereotactic body radiation therapy and limited resection are being used more frequently to treat intrathoracic malignancies. Effective local control requires precise radiation target delineation or complete resection. Lung biopsy tracts (LBT) on computed tomography (CT) scans after the use of tract sealants can mimic malignant tract seeding (MTS) and it is unclear whether these LBTs should be included in the calculated tumor volume or resected...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904736/lung-cancer-specialists-opinions-on-treatment-for-stage-i-non-small-cell-lung-cancer-a-multidisciplinary-survey
#2
Austin Lammers, Timur Mitin, Drew Moghanaki, Charles R Thomas, Robert Timmerman, Sara E Golden, Sujata Thakurta, Rafal Dziadziuszko, Christopher G Slatore
Purpose: The current standard of care for surgically eligible stage I non-small cell lung cancer (NSCLC) is surgical resection, but emerging data suggest that stereotactic body radiation therapy (SBRT) is potentially as effective as surgery. However, specialist views of the current evidence about SBRT and how they would incorporate a randomized controlled trial (RCT) into practice is unclear. We sought to understand specialist opinions about evidence regarding treatment of stage I NSCLC and how this translates into practice and clinical trial implementation...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29895629/pattern-and-predictors-of-outpatient-palliative-care-referral-among-thoracic-medical-oncologists
#3
David Hui, Kelly Kilgore, Minjeong Park, Diane Liu, Yu Jung Kim, Ji Chan Park, Frank Fossella, Eduardo Bruera
BACKGROUND: There is significant variation in access to palliative care. We examined the pattern of outpatient palliative care referral among thoracic medical oncologists and identified oncologist characteristics associated with greater referral. MATERIALS AND METHODS: We retrieved data on all patients who died of advanced thoracic malignancies at our institution between January 1, 2007, and December 31, 2012. Using median as a cutoff, we defined two groups (high-referring and low-referring oncologists) based on their frequency of referral...
June 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29885479/iaslc-statement-paper-liquid-biopsy-for-advanced-non-small-cell-lung-cancer-nsclc
#4
Christian Rolfo, Philip C Mack, Giorgio V Scagliotti, Paul Baas, Fabrice Barlesi, Trever G Bivona, Roy S Herbst, Tony S Mok, Nir Peled, Robert Pirker, Luis E Raez, Martin Reck, Jonathan W Riess, Lecia V Sequist, Frances A Shepherd, Lynette M Sholl, Daniel Sw Tan, Heather A Wakelee, Ignacio I Wistuba, Murry W Wynes, David P Carbone, Fred R Hirsch, David R Gandara
The isolation of circulating cell-free tumoral DNA (ctDNA) in plasma and its subsequent molecular analysis is a powerful tool that can help improve clinical outcomes across multiple cancer types, including non-small cell lung cancer (NSCLC). Assays of this nature that utilize blood as opposed to tumor samples are frequently referred to as liquid biopsies. An increasing number of new platforms have been recently developed that improve not only the fidelity of the molecular analysis of the liquid biopsy but also the number of tests performed on a single specimen...
June 6, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29875838/assembly-11-thoracic-oncology
#5
Clementine Bostantzoglou, Nir Peled
Meet @ERStalk Assembly 11: thoracic oncology http://ow.ly/6Fhb30js5LE.
June 2018: Breathe
https://www.readbyqxmd.com/read/29870283/use-of-inpatient-palliative-care-by-type-of-malignancy
#6
Jessica M Ruck, Joseph K Canner, Thomas J Smith, Fabian M Johnston
BACKGROUND: Although mounting evidence supports the use of palliative care (PC) to improve care experiences and quality of life for oncology patients, the frequency of and factors associated with PC use during oncology-related hospitalizations remain unknown. MATERIALS AND METHODS: Using the National Inpatient Sample dataset, hospitalizations during 2012-2014 for a primary diagnosis of cancer with high risk of in-hospital mortality were identified. PC use was identified using the V66...
June 5, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29807638/pet-ct-interpretative-pitfalls-in-thoracic-malignancies
#7
Girish S Shroff, Bradley S Sabloff, Mylene T Truong, Brett W Carter, Chitra Viswanathan
Applications of positron emission tomography/computed tomography (PET/CT) in the thorax include the evaluation of solitary pulmonary nodules, staging and restaging of oncologic patients, assessment of therapeutic response, and detection of residual or recurrent disease. Accurate interpretation of PET/CT requires knowledge of the physiological distribution of [18F]-fluoro-2-deoxy-D-glucose, as well as artifacts and quantitative errors due to the use of CT for attenuation correction of the PET scan. Potential pitfalls include malignancies that are PET negative and benign conditions that are PET positive...
June 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29791936/is-right-sleeve-lower-lobectomy-necessary-is-it-safe
#8
Celalettin Ibrahim Kocaturk, Ozkan Saydam, Celal Bugra Sezen, Cem Emrah Kalafat, Levent Cansever, Ali Cevat Kutluk, Hasan Akin, Muzaffer Metin
OBJECTIVES:  The right sleeve lower lobectomy is the least used of the bronchial sleeve operations. There are only case-based studies in the literature. In this study, we compared this technique to those used in patients who underwent a right lower bilobectomy. METHODS:  We retrospectively reviewed the data of patients who had been operated on due to non-small cell lung cancer (NSCLC) from January 2005 to December 2015 from a dataset that was formed prospectively...
May 23, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29785298/impact-of-near-infrared-angiography-on-the-quality-of-anatomical-resection-during-video-assisted-thoracic-surgery-segmentectomy
#9
Benoît Bédat, Frédéric Triponez, Samira Mercedes Sadowski, Christophe Ellenberger, Marc Licker, Wolfram Karenovics
Background: The aim of the present study was to assess the impact of near-infrared angiography in guiding intraoperatively sublobar anatomical resection by video-assisted thoracic surgery (VATS). Methods: We retrospectively analyzed data from 67 patients who underwent segmentectomy by VATS from November 2014 to November 2017 at the University Hospitals of Geneva, Switzerland. The need to modify arterial or parenchymal resection based on intraoperative near-infrared imaging was considered the primary study outcome...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29785289/what-is-the-role-of-wedge-resection-for-t1a-lung-cancer
#10
Sebron Harrison, Brendon Stiles, Nasser Altorki
Since 1995, lobar resection became the standard of care for medically fit patients with early stage lung cancer. This was based on the results of a single randomized trial comparing lobectomy and sublobar resection (SLR) in stage I lung cancer conducted by the lung cancer study group between 1982 and 1988. The conclusions of the study included a statistically significant tripling in loco-regional recurrence (LR) after limited resection but no difference between the two arms of the trial in systemic recurrence...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29782588/ground-glass-pulmonary-nodules-their-significance-in-oncology-patients-and-the-role-of-computer-tomography-and-18f-fluorodeoxyglucose-positron-emission-tomography
#11
Laura Evangelista, Annalori Panunzio, Elena Scagliori, Paolo Sartori
Objective: to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancies and to evaluate the role of computed tomography (CT) and positron emission tomography (PET)/CT in their diagnosis and follow-up. Methods: A total of 130 nodules in 68 patients were revealed: 119 GGNs and 11 MPNs. GGN lesions were found in 58 patients, MPNs in eight, and in two cases, both...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29766306/intraoperative-conversion-does-not-affect-the-oncological-outcomes-of-minimally-invasive-esophagectomy-for-treatment-of-esophageal-cancer
#12
Xue-Hai Liu, Yi Hu, Kun-Kun Li, Ying-Jian Wang, Yao-Guang Jiang, Wei Guo
BACKGROUND: The aim of this study is to summarize the causes and implications of intraoperative conversion from minimally invasive esophagectomy (MIE) to open thoracotomy, and to evaluate the effect on long-term survival. METHODS: There were 293 thoracoscopic esophagectomies for esophageal squamous cell carcinoma (ESCC) of the thoracic esophagus performed by the authors from September 2009 to August 2015. Totally, 257 patients were enrolled in this study. These patients were divided into two groups (those underwent complete MIE and those converted to open thoracotomy) and then compared...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29756991/the-immune-landscape-of-non-small-cell-lung-cancer-utility-of-cytologic-and-histologic-samples-obtained-through-minimally-invasive-pulmonary-procedures
#13
Jason Beattie, Lonny Yarmus, Momen Wahidi, M Patricia Rivera, Christopher Gilbert, Fabien Maldonado, Kasia Czarnecka, Angela Argento, Alexander Chen, Felix Herth, Daniel H Sterman
The success of immune checkpoint inhibitors and the discovery of useful biomarkers to predict response to these agents has shifted much of the focus of personalized care for advanced non-small cell lung cancer towards harnessing the immune response. With further advancement, more effective immunotherapy options will emerge along with more useful biomarkers. For patients with advanced disease, minimally invasive techniques will remain most appropriate for acquisition of tissue. This is in contrast to default gold-standard large tissue specimens obtained through surgical resection...
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29747874/is-prophylactic-cranial-irradiation-indicated-for-patients-with-extensive-stage-small-cell-lung-cancer-with-a-complete-response-to-first-line-treatment
#14
Ryoko Suzuki, Ritsuko Komaki
Prophylactic cranial irradiation (PCI) has been considered standard of care for patients with limited-stage small-cell lung cancer who achieve complete response to definitive treatment after a meta-analysis revealed its favorable effects on survival. In a European trial, PCI was also shown to confer a survival advantage for patients with extensive-stage (ES) SCLC who experienced any positive response after initial chemotherapy, leading to PCI also being considered a standard treatment for these patients as well...
May 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29744223/european-perspectives-in-thoracic-surgery-the-ests-venous-thromboembolism-vte-working-group
#15
REVIEW
Yaron Shargall, Virginia R Litle
Venous thromboembolism (VTE), composed of deep vein thrombosis (DVT) and PE is a well-recognized cause for significant perioperative morbidity and mortality. While in orthopedic surgery and general oncology surgery there are well established guidelines regarding VTE prophylaxis, based on carefully conducted high level studies, in thoracic surgery the level of evidence and overall knowledge in the field is still lacking, The European Society of Thoracic Surgeons have established an international working group in 2016, whose task was the define contemporary best practice, coordinate research efforts and eventually define best practice guidelines...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29744221/how-to-get-the-best-from-robotic-thoracic-surgery
#16
REVIEW
Sara Ricciardi, Carmelina Cristina Zirafa, Federico Davini, Franca Melfi
The application of Robotic technology in thoracic surgery has become widespread in the last decades. Thanks to its advanced features, the robotic system allows to perform a broad range of complex operations safely and in a comfortable way, with valuable advantages related to low invasiveness. Regarding lung tumours, several studies have shown the benefits of robotic surgery including lower blood loss and improved lymph node removal when compared with other minimally invasive techniques. Moreover, the robotic instruments allow to reach deep and narrow spaces permitting safe and precise removal of tumours located in remote areas, such as retrosternal and posterior mediastinal spaces with outstanding postoperative and oncological results...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29732436/the-c7-pedicle-as-a-superior-fixation-point-in-spinal-stabilization-for-spinal-metastatic-disease
#17
Harjot Thind, Andrew J Fabiano
Spinal metastatic disease (SMD) often requires spinal stabilization; however, the cervicothoracic junction can be a challenging area to instrument. An anterior approach may require division of the sternum. A posterior or posterolateral approach may rely on cervical lateral mass screws for superior construct fixation that are more prone to pullout than screws placed in a pedicle. The C7 pedicle is able to support pedicle screw fixation in most instances based on morphological features of the vertebra. When the C7 pedicle is used as a superior fixation point, it aligns with the thoracic pedicles below to create a streamlined posterior construct...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29730942/-perioperative-factors-influencing-the-tolerability-of-chemotherapy-after-lung-lobe-resection
#18
Aurél Ottlakán, Balázs Pécsy, Edit Csada, Gábor Ádám, Anikó Maráz, Bernadett Borda, György Lázár, József Furák
INTRODUCTION: Lung cancer is the leading cause of malignancy-related deaths in Hungary, involving complex surgical and oncological treatment. AIM: Factors influencing the tolerability of complete/planned and incomplete postoperative chemotherapy after surgery were analyzed. METHOD: During a 6-year period (January 1, 2011-December 31, 2016), data of 72 patients operated with lung cancer (adenocarcinoma and squamous cell carcinoma), receiving complete (4 cycles) and incomplete (<4 cycles) postoperative chemotherapy were analyzed...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29729609/virtual-surgical-planning-and-three-dimensional-printing-in-multidisciplinary-oncologic-chest-wall-resection-and-reconstruction-a-case-report
#19
Basel Sharaf, M Diya Sabbagh, Aparna Vijayasekaran, Mark Allen, Jane Matsumoto
INTRODUCTION: Primary sarcomas of the sternum are extremely rare and present the surgical teams involved with unique challenges. Historically, local muscle flaps have been utilized to reconstruct the resulting defect. However, when the resulting oncologic defect is larger than anticipated, local tissues have been radiated, or when preservation of chest wall muscles is necessary to optimize function, local reconstructive options are unsuitable. PRESENTATION OF CASE: Virtual surgical planning (VSP) and in house three-dimensional (3D) printing provides the platform for improved understanding of the anatomy of complex tumours, communication amongst surgeons, and meticulous pre-operative planning...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29723344/en-bloc-vertebrectomy-for-the-treatment-of-spinal-lesions-five-years-of-experience-in-a-single-institution-a-case-series
#20
Alex Oliveira de Araujo, Douglas Kenji Narazaki, William Gemio Jacobsen Teixeira, Cesar Salge Ghilardi, Pedro Henrique Xavier Nabuco de Araujo, Antônio Eduardo Zerati, Raphael Martus Marcon, Alexandre Fogaça Cristante, Tarcísio Eloy Pessoa de Barros Filho
OBJECTIVES: The objective of this study is to describe the experience of a Brazilian public university hospital regarding the treatment of metastatic or benign spine lesions with en bloc vertebrectomy of the thoracic and lumbar spines. METHODS: This study was a retrospective case series and included all medical records of patients with benign aggressive, primary malignant, or metastatic spine lesions who underwent en bloc vertebrectomy from 2010 to 2015. RESULTS: A total of 17 patients were included in the analysis...
2018: Clinics
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