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Thoracic oncology

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https://www.readbyqxmd.com/read/28441375/primary-adrenal-angiosarcoma-a-rare-and-potentially-misdiagnosed-tumor
#1
Ariel Grajales-Cruz, Francis Baco-Viera, Ernesto Rive-Mora, Carlos Ramirez-Tanchez, David Tasso, Norma Arroyo-Portela, Elizabeth Calderon, Ilean Joan Padua-Octaviani, William Caceres-Perkins
A man aged 69 years presented with acute right flank pain secondary to a hemorrhagic large adrenal tumor. En bloc resection was performed to repair the inferior vena cava. Immunoperoxidase levels in the tumor were positive for factor VIII and CD31 and negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of cytokeratin 7 and pankeratin...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28436378/outcomes-of-corpectomy-in-patients-with-metastatic-cancer
#2
Grzegorz Guzik
BACKGROUND: The objective of surgical management of spinal metastases is to reduce pain and improve the patient's quality of life. The operation should restore spinal stability and decompress neural structures. One surgical technique is corpectomy followed by vertebral body reconstruction and stabilisation of the spine. The procedure may be performed in patients in overall good health and a good survival prognosis. The aim of this paper is to present the outcomes of surgical management of spinal metastases in patients who underwent corpectomy followed by vertebral body reconstruction and stabilisation of the spine...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28434844/quality-and-value-of-subspecialty-reinterpretation-of-thoracic-ct-scans-of-patients-referred-to-a-tertiary-cancer%C3%A2-center
#3
Brett W Carter, Jeremy J Erasmus, Mylene T Truong, Jo-Anne O Shepard, Wayne Hofstetter, Ryan Clarke, Reginald F Munden, Joseph R Steele
INTRODUCTION: Patients referred to tertiary cancer centers often present with imaging studies performed and interpreted at other health care institutions. Although reinterpretation of imaging performed at another health care institution can reduce repeat imaging, unnecessary radiation dose, and cost, the benefit is uncertain. The purpose of this study is to evaluate the quality of initial imaging studies of patients seeking a second opinion at a tertiary cancer center, to compare the accuracy of initial interpretations to reinterpretations performed by subspecialty trained radiologists at a tertiary oncologic center, and to determine the potential impact on patient management...
April 20, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28416207/reflections-on-the-implementation-of-low-dose-computed-tomography-screening-in-individuals-at-high-risk-of-lung-cancer-in-spain
#4
Pilar Garrido, Marcelo Sánchez, José Belda Sanchis, Nicolás Moreno Mata, Ángel Artal, Ángel Gayete, José María Matilla González, José Marcelo Galbis Caravajal, Dolores Isla, Luis Paz-Ares, Luis M Seijo
Lung cancer (LC) is a major public health issue. Despite recent advances in treatment, primary prevention and early diagnosis are key to reducing the incidence and mortality of this disease. A recent clinical trial demonstrated the efficacy of selective screening by low-dose computed tomography (LDCT) in reducing the risk of both lung cancer mortality and all-cause mortality in high-risk individuals. This article contains the reflections of an expert group on the use of LDCT for early diagnosis of LC in high-risk individuals, and how to evaluate its implementation in Spain...
April 14, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28408243/erlotinib-and-bevacizumab-in-patients-with-advanced-non-small-cell-lung-cancer-and-activating-egfr-mutations-belief-an-international-multicentre-single-arm-phase-2-trial
#5
Rafael Rosell, Urania Dafni, Enriqueta Felip, Alessandra Curioni-Fontecedro, Oliver Gautschi, Solange Peters, Bartomeu Massutí, Ramon Palmero, Santiago Ponce Aix, Enric Carcereny, Martin Früh, Miklos Pless, Sanjay Popat, Athanasios Kotsakis, Sinead Cuffe, Paolo Bidoli, Adolfo Favaretto, Patrizia Froesch, Noemí Reguart, Javier Puente, Linda Coate, Fabrice Barlesi, Daniel Rauch, Michael Thomas, Carlos Camps, Jose Gómez-Codina, Margarita Majem, Rut Porta, Riyaz Shah, Emer Hanrahan, Roswitha Kammler, Barbara Ruepp, Manuela Rabaglio, Marie Kassapian, Niki Karachaliou, Rachel Tam, David S Shames, Miguel A Molina-Vila, Rolf A Stahel
BACKGROUND: The tyrosine kinase inhibitor erlotinib improves the outcomes of patients with advanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations. The coexistence of the T790M resistance mutation with another EGFR mutation in treatment-naive patients has been associated with a shorter progression-free survival to EGFR inhibition than in the absence of the T790M mutation. To test this hypothesis clinically, we developed a proof-of-concept study, in which patients with EGFR-mutant NSCLC were treated with the combination of erlotinib and bevacizumab, stratified by the presence of the pretreatment T790M mutation...
April 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28399060/thoracoscopic-esophagectomy-in-the-prone-position-versus-the-lateral-position-hand-assisted-thoracoscopic-surgery-a-retrospective-cohort-study-of-127-consecutive-esophageal-cancer-patients
#6
Naoya Fukuda, Toshiaki Shichinohe, Yuma Ebihara, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Yo Kurashima, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Satoshi Hirano
PURPOSE: To assess the validity of esophagectomy with the patient in the prone position (PP), the short-term surgical results of PP and hand-assisted thoracoscopic surgery (HATS) were compared. METHODS: This study enrolled 127 patients who underwent esophagectomy with HATS (n=91) or PP (n=36) between October 1999 and September 2014. The patients' background characteristics, operative findings, and postoperative complications were examined. RESULTS: The patients' background characteristics were not significantly different...
April 10, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28395387/novel-techniques-and-approaches-to-minimally-invasive-thoracic-surgery
#7
Osita Onugha, Rasheed Ivey, Robert McKenna
Approximately two decades ago, thoracic surgery witnessed the leap from thoracotomy to the first video-assisted thoracic surgery (VATS) lobectomy. Minimally invasive lobectomy and hilar lymphadenectomy is now widely established as a safe and oncological sound technique that is the standard of care for early-stage lung cancer. The move toward less invasive surgery has no doubt driven the innovation of sophisticated instruments and technology to cope with the demanding need of working through a restricted incision...
April 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28365781/the-lung-cancer-surgical-study-group-of-the-japan-clinical-oncology-group-past-activities-current-status-and-future-direction
#8
Kazuo Nakagawa, Shun-Ichi Watanabe, Hideo Kunitoh, Hisao Asamura
The Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group was organized in 1986. Initially, 26 collaborative institutions participated. In the early period, the Lung Cancer Surgical Study Group focused on combined modality therapies and conducted nine trials, including JCOG9101: adjuvant chemotherapy for resected small-cell lung cancer, and JCOG9806: induction chemoradiotherapy followed by surgery for superior sulcus tumor, which greatly impacted the treatment strategies for some special kinds of lung cancer...
March 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28317123/motion-management-strategies-and-technical-issues-associated-with-stereotactic-body-radiotherapy-of-thoracic-and-upper-abdominal-tumors-a-review-from-nrg-oncology
#9
Edward D Brandner, Indrin J Chetty, Tawfik G Giaddui, Ying Xiao, M Saiful Huq
The efficacy of stereotactic body radiotherapy (SBRT) has been well demonstrated. However, it presents unique challenges for accurate planning and delivery especially in the lungs and upper abdomen where respiratory motion can be significantly confounding accurate targeting and avoidance of normal tissues. In this paper, we review the current literature on SBRT for lung and upper abdominal tumors with particular emphasis on addressing respiratory motion and its affects. We provide recommendations on strategies to manage motion for different, patient-specific situations...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28298733/pitfalls-and-artifacts-in-the-interpretation-of-oncologic-pet-ct-of-the-chest
#10
Gustavo de Souza Portes Meirelles, Julia Capobianco, Marco Antônio Condé de Oliveira
PET/CT is widely used for the evaluation of patients with thoracic malignancies. Although the levels of (18)F-fluorodeoxyglucose (FDG) uptake are usually high in neoplastic diseases, they can also be physiological, due to artifacts. In addition, FDG uptake can occur in benign conditions such as infectious, inflammatory, and iatrogenic lesions. Furthermore, some malignant tumors, such as adenocarcinoma in situ (formerly known as bronchoalveolar carcinoma) and carcinoid tumors, may not show FDG uptake. Here, we illustrate the main pitfalls and artifacts in the interpretation of the results of oncologic PET/CT of the chest, outlining strategies for avoiding misinterpretation...
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28294667/-initial-experiences-with-vats-lobectomy
#11
Pál Gehér, Árpád Füredi, László István Kecskés, Béla Kiss
OBJECTIVE: The authors analyse the experience of videothoracoscopic (VATS) lung lobectomies performed since December 2010 at the Thoracic Surgery Department of Markusovszky University Teaching Hospital. PATIENTS AND METHOD: 78 patients (44 men and 34 women) underwent VATS lobectomy. The average age was 61.2 years ranging from 30 to 80. The indications were peripheral malignancy (35 cases) or the suspicion of that (43 cases), presence of curable distant metastasis was not considered as contraindication...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28262299/high-risk-for-thoracotomy-but-not-thoracoscopic-lobectomy
#12
Laura L Donahoe, Moira de Valence, Eshetu G Atenafu, Waël C Hanna, Thomas K Waddell, Andrew F Pierre, Kazuhiro Yasufuku, Marc de Perrot, Marcelo Cypel, Shaf Keshavjee, Gail E Darling
BACKGROUND: Pulmonary lobectomy is the standard of care for resection of non-small cell lung cancer (NSCLC). Patients with compromised lung function who are considered high risk may be denied surgical treatment; thus, proper identification of those truly at high risk is critical. Video-assisted thoracic surgery (VATS) may reduce the operative risk. This study reviews our institutional experience of pulmonary lobectomy by open thoracotomy or VATS techniques in patients deemed to be high risk...
March 2, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28230245/ct-guided-percutaneous-hookwire-localization-increases-the-efficacy-and-safety-of-vats-for-pulmonary-nodules
#13
Theo J Klinkenberg, Lars Dinjens, Rienhart F E Wolf, Anthonie J van der Wekken, Caroline van de Wauwer, Geertruida H de Bock, Wim Timens, Massimo A Mariani, Harry J M Groen
BACKGROUND AND OBJECTIVES: The diagnosis of pulmonary nodules of unknown origin is challenging, and such nodules are not always suitable for transthoracic needle biopsy. With the advent of video assisted thoracic surgery (VATS) and CT-guided percutaneous hookwire localization (CT-PHL) we hypothesized that the combination of these two procedures will improve early diagnosis. METHODS: Selection criteria were a nodule not well approachable with fine needle biopsy and the therapeutic consequences of a diagnosis as assessed by the multidisciplinary oncology board...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28210298/thoracic-oncology-hermes-european-curriculum-recommendations-for-training-in-thoracic-oncology
#14
REVIEW
Fernando Gamarra, Julie-Lyn Noël, Alessandro Brunelli, Anne-Marie C Dingemans, Enriqueta Felip, Mina Gaga, Bogdan Dragos Grigoriu, Georgia Hardavella, Rudolf M Huber, Samuel Janes, Gilbert Massard, Paul Martin Putora, Jean-Paul Sculier, Philipp A Schnabel, Sara Ramella, Dirk Van Raemdonck, Anne-Pascale Meert
Thoracic oncology HERMES: European curriculum recommendations for training in thoracic oncology http://ow.ly/mdqT300NHqO.
September 2016: Breathe
https://www.readbyqxmd.com/read/28161553/lower-incidence-of-esophagitis-in-the-elderly-undergoing-definitive-radiation-therapy-for-lung-cancer
#15
Payal D Soni, Philip S Boonstra, Matthew J Schipper, Latifa Bazzi, Robert T Dess, Martha M Matuszak, Feng-Ming Kong, James A Hayman, Randall K Ten Haken, Theodore S Lawrence, Gregory P Kalemkerian, Shruti Jolly
INTRODUCTION: Most patients with lung cancer are elderly and poorly represented in randomized clinical trials. They are often undertreated because of concerns about their ability to tolerate aggressive treatment. We tested the hypothesis that elderly patients undergoing definitive lung radiation might tolerate treatment differently than younger patients. METHODS: A total of 125 patients who underwent definitive lung radiotherapy were identified from a prospective institutional database (University of Michigan cohort)...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28159404/-pd1-pd-l1-immunohistochemistry-in-thoracic-oncology-where-are-we
#16
Paul Hofman, Marius Ilié, Sandra Lassalle, Elodie Long, Coraline Bence, Catherine Butori, Véronique Hofman
The assays for the assessment of the PD-L1 status by immunohistochemistry are available in clinical studies in thoracic oncology to predict response to immunotherapies targeting the PD-1/PD-L1 pathway. With the arrival of this new class of molecules in second line and very soon in first line of treatment for patients with advanced or metastatic non-small cell lung cancer, these tests will certainly be required in routine once these new drugs will be granted marketing authorization. The rapid introduction of these "companion" or "complementary" tests seems essential to select patients to benefit from these effective but also expensive and sometimes toxic therapies...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28156481/integrating-palliative-care-services-in-oncology-clinics-an-application-of-the-edmonton-symptom-assessment-system-esas
#17
Susanne Schmidt, Jessica Jones, Ifeoma Aduba, Laura LaNiel Tenner
168 Background: Research inpalliative care has shown improvements in overall survival, quality of life, symptom management, care satisfaction and reductions in the cost of care. Therefore, the American Society of Clinical Oncology has recommended early concurrent palliative care in patients with advanced cancer and with high symptom burden. Despite this recommendation, integrating palliative services at our NCI-designated cancer center has been challenging. The aims of this project were to quantitatively describe the symptom burden of patients in ambulatory oncology clinics; facilitate the establishment of an effective referral system by detecting discrepancies between symptom burden and referral practices; and improve the integration of palliative care services by implementing the Edmonton Symptom Assessment System (ESAS) tool into 5 of our oncology clinics...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156476/assessment-of-the-relationship-between-three-cancer-survivor-well-being-tools
#18
Mary Jo Deprey, Stuart Chamovitz, Marty Jacobson, Kathleen Hall
74 Background: In 1999, the National Comprehensive Cancer Network issued guidelines for improving well-being of cancer survivors. Three tools, the Eastern Cooperative Oncology Group Performance Status (ECOGPS), the National Comprehensive Cancer Network Distress Thermometer (NCCNDT), and the Subjective Happiness Scale (SHS), are currently being used in a rural oncology survivorship clinic to assess patients' well-being. The question arose whether all three tools are necessary for adequate patient assessment...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152759/implementation-of-a-new-patient-health-questionnaire-into-standard-practice-in-outpatient-cancer-clinics-to-improve-patient-care-and-quality-of-treatment
#19
Catherine Brown, Andrea Perez-Cosio, Gursharan Gill, Mindy Liang, Geoffrey Liu
214 Background: Patient socio-demographic, lifestyle, and risk factor information at the Princess Margaret Cancer Centre (PM) is routinely collected for clinical purposes. The only standardized patient information presently being gathered in the outpatient cancer clinics at the PM is symptom management data, which is linked directly into the electronic medical records. Collecting and recording additional data can improve the quality of patient care, help identify risk factors, and guide treatment options. Our aim was to determine the feasibility of collecting this additional information in a clinical setting...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152712/application-of-a-standard-practice-based-system-to-measure-and-compare-quality-of-cancer-survivorship-care
#20
Katherine Ramsey Gilmore, Patricia Chapman, Paula A Lewis-Patterson, Maria Alma Rodriguez
239 Background: Despite the growing committment to improve survivorship care, measuring its quality remains difficult. In 2006, the American Society of Clinical Oncologists (ASCO) launched a practice-based system known as the Quality Oncology Practice Initiative (QOPI) to measure the quality of cancer care. Here, we demonstrate the use of QOPI procedures to compare compliance with survivorship care plans (SCPs) across different disease-specific clinics. METHODS: Measures based on survivorship clinical practice guidelines were abstracted from SCPs issued to survivors scheduled for appointments in site-specific clinics...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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