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Thoracic oncology

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https://www.readbyqxmd.com/read/29678596/evaluation-of-acute-skin-toxicity-of-breast-radiotherapy-using-thermography-results-of-a-prospective-single-centre-trial
#1
O Maillot, N Leduc, V Atallah, P Escarmant, A Petit, S Belhomme, P Sargos, V Vinh-Hung
PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced dermatitis...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29662557/ct-radiomics-in-thoracic-oncology-technique-and-clinical-applications
#2
REVIEW
Geewon Lee, So Hyeon Bak, Ho Yun Lee
Precision medicine offers better treatment options and improved survival for cancer patients based on individual variability. As the success of precision medicine depends on robust biomarkers, the requirement for improved imaging biomarkers that reflect tumor biology has grown exponentially. Radiomics, the field of study in which high-throughput data are generated and large amounts of advanced quantitative features are extracted from medical images, has shown great potential as a source of quantitative biomarkers in the field of oncology...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29625898/palliative-thoracic-radiation-therapy-for-non-small-cell-lung-cancer-2018-update-of-an-american-society-for-radiation-oncology-astro-evidence-based-guideline
#3
Benjamin Moeller, Ehsan H Balagamwala, Aileen Chen, Kimberly M Creach, Giuseppe Giaccone, Matthew Koshy, Sandra Zaky, George Rodrigues
PURPOSE: To revise the recommendation on the use of concurrent chemotherapy (CC) with palliative thoracic external beam radiation therapy (EBRT) made in the original 2011 American Society for Radiation Oncology guideline on palliative thoracic radiation for lung cancer. METHODS AND MATERIALS: Based on a systematic PubMed search showing new evidence for this key question, the task force felt an update was merited. Guideline recommendations were created using a predefined consensus-building methodology supported by American Society for Radiation Oncology-approved tools for grading evidence quality and recommendation strength...
April 3, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29623736/treatment-of-venous-stenosis-in-oncologic-patients
#4
Anna Maria Ierardi, Maria Laura Jannone, Mario Petrillo, Pietro Maria Brambillasca, Enrico Maria Fumarola, Salvatore Alessio Angileri, Matteo Crippa, Gianpaolo Carrafiello
Symptomatic obstruction related to malignant involvement of large veins may occur in central veins both in the thoracic and pelvic regions, and in the abdominal region of the body. Both cases represent a therapeutic challenge, and endovascular revascularization, consisting of angioplasty and stent placement, is safe and effective. Superior vena cava stenting has become widespread in the management of occlusive venous disease. The percutaneous placement of large expandable metal stents allows rapid restoration of normal blood flow in the majority of patients, thus improving symptoms...
April 6, 2018: Future Oncology
https://www.readbyqxmd.com/read/29616463/the-influence-of-comorbidity-on-the-postoperative-survival-in-elderly-%C3%A2-75-years-old-with-lung-cancer
#5
Tokujiro Yano, Mototsugu Shimokawa, Osamu Kawashima, Mitsuhiro Takenoyama, Yoshinori Yamashita, Takeshi Fukami, Tsuyoshi Ueno, Eiji Yatsuyanagi, Seiichi Fukuyama
OBJECTIVES: We conducted a multi-institutional prospective observational study of elderly patients (≥ 75 years-old) with resected non-small cell lung cancer. In this report, we have followed the cohorts for 2 years after surgery and examined both the influence of preoperative comorbidity [Adult Comorbidity Evaluation-27 (ACE-27) index] on the postoperative survival and the change in the Karnofsky Performance Status (KPS). METHODS: From March 2014 to April 2015, 264 patients were prospectively registered from 22 hospitals affiliated with the National Hospital Organization...
April 3, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29605962/ten-years-experience-in-robotic-assisted-thoracic-surgery-for-early-stage-lung-cancer
#6
Monica Casiraghi, Domenico Galetta, Alessandro Borri, Adele Tessitore, Rosalia Romano, Cristina Diotti, Daniela Brambilla, Patrick Maisonneuve, Lorenzo Spaggiari
BACKGROUND:  This study analyzed the short- and long-term outcomes of robotic-assisted thoracic surgery (RATS) for early stage non-small cell lung cancer (NSCLC). METHODS:  From November 2006 to December 2016, we performed 363 RATS procedures. This study retrospectively reviewed 339 patients who underwent RATS for clinical stages I ( n  = 318) or II ( n  = 21) NSCLC. RESULTS:  Twenty-nine patients underwent segmentectomy, 307 lobectomy, and 3 pneumonectomy...
April 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29600073/microrna-expression-profile-in-primary-lung-cancer-cells-lines-obtained-by-endobronchial-ultrasound-transbronchial-needle-aspiration
#7
Juliana Guarize, Fabrizio Bianchi, Elena Marino, Elena Belloni, Manuela Vecchi, Stefano Donghi, Giorgio Lo Iacono, Chiara Casadio, Roberto Cuttano, Massimo Barberis, Pier Paolo Di Fiore, Francesco Petrella, Lorenzo Spaggiari
Background: Novel cancer biomarkers like microRNA (miRNA) are promising tools to gain a better understanding of lung cancer pathology and yield important information to guide therapy. In recent years, new less invasive methods for the diagnosis and staging of NSCLC have become key tools in thoracic oncology and the worldwide spread of endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA). However, appropriate specimen handling is mandatory to achieve adequate results and reproducibility...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29587930/-shanghai-pulmonary-hospital-experts-consensus-on-the-management-of-ground-glass-nodules-suspected-as-lung-adenocarcinoma-version-1
#8
Gening Jiang, Chang Chen, Yuming Zhu, Dong Xie, Jie Dai, Kaiqi Jin, Yingran Shen, Haifeng Wang, Hui Li, Lanjun Zhang, Shugeng Gao, Keneng Chen, Lei Zhang, Xiao Zhou, Jingyun Shi, Hao Wang, Boxiong Xie, Lei Jiang, Jiang Fan, Deping Zhao, Qiankun Chen, Liang Duan, Wenxin He, Yiming Zhou, Hongcheng Liu, Xiaogang Zhao, Peng Zhang, Xiong Qin
Background and objective As computed tomography (CT) screening for lung cancer becomes more common in China, so too does detection of pulmonary ground-glass nodules (GGNs). Although anumber of national or international guidelines about pulmonary GGNs have been published,most of these guidelines are produced by respiratory, oncology or radiology physicians, who might not fully understand the progress of modern minimal invasive thoracic surgery, and these current guidelines may overlook or underestimate the value of thoracic surgery in the management of pulmonary GGNs...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29581681/robot-assisted-mckeown-esophagectomy-is-feasible-after-neoadjuvant-chemoradiation-our-initial-experience
#9
Ashish Goel, Swati H Shah, Veda Padma Priya Selvakumar, Shubha Garg, Kapil Kumar
Neoadjuvant chemoradiation has become the standard of care for esophageal cancer, especially for middle third esophageal lesions and those with squamous histology. Although more and more thoracic surgeons and surgical oncologists have now shifted to video-assisted and robot-assisted thoracoscopic esophagectomy; there is still limited experience for the use of minimal-assisted approaches in patients undergoing surgery after neoadjuvant chemoradiation. Most surgeons have concerns of feasibility, safety, and oncological outcomes as well as issues related to difficult learning curve in adopting robotic esophagectomy in patients after chemoradiation...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29573050/mri-for-solitary-pulmonary-nodule-and-mass-assessment-current-state-of-the-art
#10
Yoshiharu Ohno, Hans-Ulrich Kauczor, Hiroto Hatabu, Joon Beom Seo, Edwin J R van Beek
Since the clinical introduction of magnetic resonance imaging (MRI), the chest has been one of its most challenging applications, and many physicists and radiologists have tried since the 1980s to use MR for assessment of different lung diseases as well as mediastinal and pleural diseases. Since then, however, technical advances in sequencing, scanners, and coils, adaptation of parallel imaging techniques, utilization of contrast media, and development of postprocessing tools have been reported by many basic and clinical researchers...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29571993/is-heterogeneity-in-stage-3-non-small-cell-lung-cancer-obscuring-the-potential-benefits-of-dose-escalated-concurrent-chemo-radiotherapy-in-clinical-trials
#11
REVIEW
Andrew Hudson, Clara Chan, David Woolf, Alan McWilliam, Crispin Hiley, James O'Connor, Neil Bayman, Fiona Blackhall, Corinne Faivre-Finn
The current standard of care for the management of inoperable stage 3 non-small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (cCRT) using radiotherapy dose-fractionation and chemotherapy regimens that were established 3 decades ago. In an attempt to improve the chances of long-term control from cCRT, dose-escalation of the radiotherapy dose was assessed in the RTOG 0617 randomised control study comparing the standard 60 Gy in 30 fractions with a high-dose arm receiving 74 Gy in 37 fractions...
April 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29571552/imaging-of-oncologic-emergencies
#12
Francesca Iacobellis, Alessandra Perillo, Isabella Iadevito, Michela Tanga, Luigia Romano, Roberto Grassi, Refky Nicola, Mariano Scaglione
Oncologic emergencies can be either the result of the primary tumor, its metastasis, a paraneoplastic syndrome or reaction to the chemotherapy. Imaging plays a crucial role in ensuring a prompt diagnosis as well as assisting in the therapeutic management. In this article, we discuss the common thoracic and abdominal oncological emergencies that may be encountered in an emergency department.
April 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29558830/naturopathic-oncology-care-for-thoracic-cancers-a-practice-survey
#13
Dugald Seely, Julie K Ennis, Ellen McDonell, Linlu Zhao
BACKGROUND AND OBJECTIVES: There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic goals; and (3) identify potential contraindications between integrative and conventional therapies. METHODS: Oncology Association of Naturopathic Physicians (OncANP) members (n = 351) were invited to complete an electronic survey...
March 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29535011/translation-of-knowledge-to-practice-improving-awareness-in-nsclc-molecular-testing
#14
Alona Zer, Jean Claude Cutz, Harman Sekhon, David M Hwang, Christina Sit, Manjula Maganti, Mike Sung, Matthew Binnie, Anthony Brade, Tae Bong Chung, Suzanne Kamel-Reid, Paul Narinder, Ming S Tsao, Tom Waddell, Gilda da Cunha Santos, Milan Patel, Ron F Carter, Natasha B Leighl
BACKGROUND: Molecular testing in advanced lung cancer is standard in guiding treatment selection. However, population-wide implementation of testing remains a challenge. We developed a knowledge translation intervention to improve understanding among diagnostic specialists about molecular testing and appropriate diagnostic sampling in lung cancer. METHODS: Specialty-specific education programs were developed from existing literature and input from Canadian leaders in lung pathology, respirology, interventional radiology, thoracic surgery, radiation and medical oncology...
March 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29526176/-the-initial-experience-of-video-assisted-thoracic-surgery-segmentectomy-for-early-stage-lung-cancer
#15
Shaohua Ma, Tiansheng Yan, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Hailong Liang
BACKGROUND: Segmentectomy can retains more healthy lung tissue than lobectomy, but it remains controversial in oncology for early stage lung cancer. The aim of this study is to discuss the problems of video-assisted thoracic surgery (VATS) segmentectomy in early stage lung cancer, by analyzing the clinical and pathological data of 35 cases and reviewing the literature. METHODS: There were 35 patients who received segmentectomy by complete video-assisted thoracic surgery, from May 2013 to July 2017, in single operation group in the Third Hospital of Peking University...
February 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29521649/overall-survival-results-of-the-feasibility-study-of-adjuvant-chemotherapy-with-docetaxel-plus-cisplatin-followed-by-long-term-single-agent-administration-of-s-1-in-patients-with-completely-resected-non-small-cell-lung-cancer-thoracic-oncology-research-group
#16
Seiji Niho, Norihiko Ikeda, Hiroshi Michimae, Kenji Suzuki, Hiroshi Sakai, Takayuki Kaburagi, Katsuo Yoshiya, Koichi Minato, Terufumi Kato, Hiroaki Okamoto, Takashi Seto, Yukio Hosomi, Kimihiro Shimizu, Haruhiro Saito, Masanori Tsuchida, Hideo Kunitoh, Masahiro Tsuboi, Masahiro Takeuchi, Koshiro Watanabe
OBJECTIVES: The TORG0809 study was a multicenter feasibility study of long-term single-agent therapy with S-1 after docetaxel plus cisplatin therapy in patients with completely resected stage II or stage IIIA non-small cell lung cancer. We report the results of the final overall survival (OS) analysis. PATIENTS AND METHODS: A total of 129 eligible patients received 3 cycles of docetaxel (60 mg/m, day 1) plus cisplatin (80 mg/m, day 1), followed by S-1 at 40 mg/m twice daily for 14 consecutive days, for >6 months (maximum, 1 y)...
March 7, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29514666/analysis-of-factors-delaying-the-surgical-treatment-of-patients-with-neurological-deficits-in-the-course-of-spinal-metastatic-disease
#17
Grzegorz Guzik
BACKGROUND: Thoracic spine cancer metastases is frequently the cause of neurological deficits. Despite the availability of diagnostics, delays in treatment are still quite common. The aim of this work is to analyze the reasons for delayed diagnostics and treatment, in patients with neurological deficits in the course of metastatic spine disease. METHODS: In our study patients medical data was analyzed from 2013 to 2015. The analysis covered the following aspects: symptoms of metastases, time of neurological deficits occurrence, where and when initial diagnostics were performed, time from diagnosis to proper surgical treatment in an oncological centre...
March 7, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29514185/mid-term-survival-outcome-of-single-port-video-assisted-thoracoscopic-anatomical-lung-resection-a-two-centre-experience
#18
Ching Feng Wu, Ricardo Fernandez, de la Torre Mercedes, Maria Delgado, Eva Fieira, Ching Yang Wu, Ming Ju Hsieh, Marina Paradela, Yun-Hen Liu, Diego Gonzalez-Rivas
OBJECTIVES: Single-port video-assisted thoracoscopic surgery (SPVATS) anatomical resection has been shown to be a feasible technique for lung cancer patients. Whether SPVATS has equivalent or better oncological outcomes for lung cancer patients remains controversial. The purpose of this study was to evaluate the perioperative and mid-term survival outcomes of SPVATS in 2 different medical centres. METHODS: We retrospectively reviewed patients who underwent SPVATS anatomical resections between January 2014 and February 2017 in Coruña University Hospital's Minimally Invasive Thoracic Surgery Unit (Spain) and Chang Gung Memorial Hospital (Taiwan)...
March 3, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29510971/oncologic-therapy-support-via-means-of-a-dedicated-mobile-app-optimise-1-protocol-for-a-prospective-pilot-trial
#19
Rami A El Shafie, Nina Bougatf, Tanja Sprave, Dorothea Weber, Dieter Oetzel, Timo Machmer, Peter E Huber, Jürgen Debus, Nils H Nicolay
BACKGROUND: The increasing role of consumer electronics and Web-enabled mobile devices in the medical sector opens up promising possibilities for integrating novel technical solutions into therapy and patient support for oncologic illnesses. A recent survey carried out at Heidelberg University Hospital suggested a high acceptance among patients for an additional approach to patient care during radiotherapy based on patient-reported outcomes by a dedicated mobile app. OBJECTIVE: The aim of this trial (OPTIMISE-1: Oncologic Therapy Support Via Means of a Dedicated Mobile App - A Prospective Feasibility Evaluation) is to prospectively evaluate the feasibility of employing a mobile app for the systematic support of radiooncological patients throughout the course of their radiotherapy by monitoring symptoms and patient performance, and facilitating the background-exchange of relevant information between patient and physician...
March 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29507799/diaphragmatic-and-pericardial-reconstruction-after-surgery-for-malignant-pleural-mesothelioma
#20
REVIEW
Piergiorgio Solli, Jury Brandolini, Alessandro Pardolesi, Marco Nardini, Nicola Lacava, Sergio Forti Parri, Kenji Kawamukai, Barbara Bonfanti, Luca Bertolaccini
Extrapleural pneumonectomy (EPP) and pleurectomy-decortication (P/D) are both recognised surgical procedures for selected cases affected by malignant pleural mesothelioma (MPM). Surgical techniques have ameliorated over the last years, remaining the complete macroscopic resection of the disease the main surgical principle. EPP is defined as an en-bloc resection of the visceral pleura, parietal pleura, pericardium and diaphragm alongside the pneumonectomy. The thoracic domain of the International Association for Study of Lung Cancer (IASLC) recently clarified the, previously confused, surgical terminology...
January 2018: Journal of Thoracic Disease
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