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https://www.readbyqxmd.com/read/28199125/one-pot-synthesis-of-%C3%AE-branched-n-acylamines-via-titanium-mediated-condensation-of-amides-aldehydes-and-organometallics
#1
Chunhui Dai, Julien Genovino, Bruce M Bechle, Matthew S Corbett, Chan Woo Huh, Colin R Rose, Jianmin Sun, Joseph S Warmus, David C Blakemore
A three-component, titanium-mediated synthesis of α-branched N-acylamines from commercial or readily accessible amides, aldehydes, and organometallic reagents is reported. The transformation proceeds under mild reaction conditions and tolerates a variety of functional groups (including nitrile, carbamate, olefin, basic amine, furan, and other sensitive heteroaromatics) to generate a large umbrella of α-branched N-acylamine products in high yields. The operationally practical procedure enables the use of this method in parallel chemical synthesis, a valuable feature that can facilitate the screening of bioactive molecules by medicinal chemists...
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28199120/one-pot-acid-catalyzed-ring-opening-cyclization-oxidation-of-aziridines-with-n-tosylhydrazones-access-to-1-2-4-triazines
#2
Lorène Crespin, Lorenzo Biancalana, Tobias Morack, David C Blakemore, Steven V Ley
A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening of the aziridine, giving access to a wide range of aminohydrazones, isolated with excellent yields. A "one-pot" procedure, combining the ring opening with a cyclization and an oxidation step, allows the preparation of diversified triazines in good yields.
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28183807/associations-of-participation-in-community-assets-with-health-related-quality-of-life-and-healthcare-usage-a-cross-sectional-study-of-older-people-in-the-community
#3
Luke A Munford, Mark Sidaway, Amy Blakemore, Matt Sutton, Pete Bower
BACKGROUND: Community assets are promoted as a way to improve quality of life and reduce healthcare usage. However, the quantitative impact of participation in community assets on these outcomes is not known. METHODS: We examined the association between participation in community assets and health-related quality of life (HRQoL) (EuroQol-5D-5L) and healthcare usage in 3686 individuals aged ≥65 years. We estimated the unadjusted differences in EuroQol-5D-5L scores and healthcare usage between participants and non-participants in community assets and then used multivariate regression to examine scores adjusted for sociodemographic and limiting long-term health conditions...
February 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28132629/a-challenging-year-of-change-lies-ahead
#4
(no author information available yet)
So, I'm back from a ten-month secondment spent primarily commissioning articles for all the RCNi specialist titles. I found the change of pace, the breadth of outlook and the increase of autonomy invigorating, but I am glad to be back as editor of Nursing Management. First of all, I'd like to thank Sophie Blakemore, now on maternity leave, for her excellent editorship of the journal since March last year; she's going to be a tough act to follow.
January 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27993132/performance-of-the-g4-xpert-%C3%A2-mtb-rif-assay-for-the-detection-of-mycobacterium-tuberculosis-and-rifampin-resistance-a-retrospective-case-control-study-of-analytical-and-clinical-samples-from-high-and-low-tuberculosis-prevalence-settings
#5
Nila J Dharan, Robert Blakemore, Alex Sloutsky, Devinder Kaur, Richard C Alexander, Minoo Ghajar, Kimberlee A Musser, Vincent E Escuyer, Marie-Claire Rowlinson, Susanne Crowe, Rafael Laniado-Laborin, Eloise Valli, Pamela Nabeta, Pamela Johnson, David Alland
BACKGROUND: The Xpert(®) MTB/RIF (Xpert) assay is a rapid PCR-based assay for the detection of Mycobacterium tuberculosis complex DNA (MTBc) and mutations associated with rifampin resistance (RIF). An updated version introduced in 2011, the G4 Xpert, included modifications to probe B and updated analytic software. METHODS: An analytical study was performed to assess Xpert detection of mutations associated with rifampin resistance in rifampin-susceptible and -resistant isolates...
December 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27991874/response-to-protocol-review-scenario-training-and-education
#6
Melodie Blakemore
No abstract text is available yet for this article.
December 19, 2016: Lab Animal
https://www.readbyqxmd.com/read/27979788/multivariate-dynamical-modelling-of-structural-change-during-development
#7
Gabriel Ziegler, Gerard R Ridgway, Sarah-Jayne Blakemore, John Ashburner, Will Penny
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems. The general approach enables modelling changes of states in multiple imaging biomarkers typically observed during brain development, plasticity, ageing and degeneration, e.g. regional gray matter volume of multiple regions of interest (ROIs). Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27890934/egr2-mutations-define-a-new-clinically-aggressive-subgroup-of-chronic-lymphocytic-leukemia
#8
E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist, F Damm
Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To study their prognostic impact, 2403 CLL patients were examined for mutations in the EGR2 hotspot region including a screening (n=1283) and two validation cohorts (UK CLL4 trial patients, n=366; CLL Research Consortium (CRC) patients, n=490). Targeted deep-sequencing of 27 known/postulated CLL driver genes was also performed in 38 EGR2-mutated patients to assess concurrent mutations...
January 3, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27843137/pi3k%C3%AE-inhibition-elicits-anti-leukemic-effects-through-bim-dependent-apoptosis
#9
M J Carter, K L Cox, S J Blakemore, A H Turaj, R J Oldham, L N Dahal, S Tannheimer, F Forconi, G Packham, M S Cragg
PI3Kδ plays pivotal roles in the maintenance, proliferation and survival of malignant B-lymphocytes. Although not curative, PI3Kδ inhibitors (PI3Kδi) demonstrate impressive clinical efficacy and, alongside other signaling inhibitors, are revolutionizing the treatment of hematological malignancies. However, only limited in vivo data are available regarding their mechanism of action. With the rising number of novel treatments, the challenge is to identify combinations that deliver curative regimes. A deeper understanding of the molecular mechanism is required to guide these selections...
December 20, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27833013/how-emotion-context-modulates-unconscious-goal-activation-during-motor-force-exertion
#10
Rebekah L Blakemore, Rémi Neveu, Patrik Vuilleumier
Priming participants with emotional or action-related concepts influences goal formation and motor force output during effort exertion tasks, even without awareness of priming information. However, little is known about neural processes underpinning how emotional cues interact with action (or inaction) goals to motivate (or demotivate) motor behaviour. In a novel functional neuroimaging paradigm, visible emotional images followed by subliminal action or inaction word primes were presented before participants performed a maximal force exertion...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27815519/a-window-of-opportunity-for-cognitive-training-in-adolescence
#11
Lisa J Knoll, Delia Fuhrmann, Ashok L Sakhardande, Fabian Stamp, Maarten Speekenbrink, Sarah-Jayne Blakemore
In the current study, we investigated windows for enhanced learning of cognitive skills during adolescence. Six hundred thirty-three participants (11-33 years old) were divided into four age groups, and each participant was randomly allocated to one of three training groups. Each training group completed up to 20 days of online training in numerosity discrimination (i.e., discriminating small from large numbers of objects), relational reasoning (i.e., detecting abstract relationships between groups of items), or face perception (i...
November 4, 2016: Psychological Science
https://www.readbyqxmd.com/read/27783255/targeting-the-protein-ubiquitination-machinery-in-melanoma-by-the-nedd8-activating-enzyme-inhibitor-pevonedistat-mln4924
#12
Kit Man Wong, Lindsey N Micel, Heather M Selby, Aik Choon Tan, Todd M Pitts, Stacey M Bagby, Anna Spreafico, Peter J Klauck, Stephen J Blakemore, Peter F Smith, Alice McDonald, Allison Berger, John J Tentler, S Gail Eckhardt
Background The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-activating enzyme (NAE) and inhibits an early step in neddylation, resulting in DNA re-replication, cell cycle arrest and death. We investigated the anti-tumor potential of pevonedistat in preclinical models of melanoma. Methods Melanoma cell lines and patient-derived tumor xenografts (PDTX) treated with pevonedistat were assessed for viability/apoptosis and tumor growth, respectively, to identify sensitive/resistant models...
February 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/27773930/non-coding-notch1-mutations-in-chronic-lymphocytic-leukemia-their-clinical-impact-in-the-uk-cll4-trial
#13
M Larrayoz, M J J Rose-Zerilli, L Kadalayil, H Parker, S Blakemore, J Forster, Z Davis, A J Steele, A Collins, M Else, D Catovsky, D G Oscier, J C Strefford
No abstract text is available yet for this article.
February 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27756341/patient-activation-in-older-people-with-long-term-conditions-and-multimorbidity-correlates-and-change-in-a-cohort-study-in-the-united-kingdom
#14
Amy Blakemore, Mark Hann, Kelly Howells, Maria Panagioti, Mark Sidaway, David Reeves, Peter Bower
BACKGROUND: Patient Activation is defined as the knowledge, skill, and confidence a patient has in managing their health. Higher levels of patient activation are associated with better self-management, better health outcomes, and lower healthcare costs. Understanding the drivers of patient activation can allow better tailoring of patient support and interventions. There are few data on patient activation in UK patients with long-term conditions. METHODS: A prospective cohort design was used...
October 18, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27741190/gestational-alloimmune-liver-disease-a-devastating-condition-preventable-with-maternal-intravenous-immunoglobulin
#15
Hannah B Anastasio, Maureen Grundy, Meredith L Birsner, Karin J Blakemore
BACKGROUND: Gestational alloimmune liver disease, a form of profound liver failure in the newborn, is the main underlying cause of the entity formerly known as neonatal hemochromatosis. Antepartum maternal intravenous immunoglobulin (IVIG) has been shown to prevent gestational alloimmune liver disease, which otherwise has a recurrence risk above 90% in subsequent pregnancies. CASE: A 30-year-old woman, gravida 3 para 0120, presented early in gestation. Her previous pregnancy had been complicated by fetal growth restriction, oligohydramnios, and ultimately fatal fulminant neonatal liver failure...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27686919/the-art-of-the-possible
#16
Sophie Blakemore
Why did you become a nurse? It was a little unexpected, I had the experience of a family member being in hospital and was inspired by the work of nurses and the difference they made.
September 30, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27647477/perception-and-recognition-of-faces-in-adolescence
#17
D Fuhrmann, L J Knoll, A L Sakhardande, M Speekenbrink, K C Kadosh, S-J Blakemore
Most studies on the development of face cognition abilities have focussed on childhood, with early maturation accounts contending that face cognition abilities are mature by 3-5 years. Late maturation accounts, in contrast, propose that some aspects of face cognition are not mature until at least 10 years. Here, we measured face memory and face perception, two core face cognition abilities, in 661 participants (397 females) in four age groups (younger adolescents (11.27-13.38 years); mid-adolescents (13.39-15...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27647145/ep12-02-extending-the-window-for-genetic-screening-sonograms-needs-assessment-for-an-ultrasound-based-down-s-syndrome-risk-model-up-to-24-weeks-gestation
#18
C B Hertenstein, K Blakemore, D L Hertenstein, C Lawson, V Corson, K Rock, K G Sagaser, J Crino
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27636910/pediatric-injuries-at-an-annual-motocross-competition-rates-and-severity
#19
Brendan A Williams, James P McFadden, Tyler L Teurlings, Laurel C Blakemore
PURPOSE: Pediatric motocross injuries occur frequently and with significant associated morbidity; however, data are limited regarding injury occurring during competition. North Central Florida hosts an annual motocross competition with numerous pediatric competitors. We sought to evaluate the rate and severity of injuries sustained at this event over a multiyear period. Our primary hypothesis was that motocross injury rates and severity in competition exceed that of other competitive sports in this age group...
September 15, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27636465/search-for-screened-interactions-associated-with-dark-energy-below-the-100%C3%A2-%C3%AE-m-length-scale
#20
Alexander D Rider, David C Moore, Charles P Blakemore, Maxime Louis, Marie Lu, Giorgio Gratta
We present the results of a search for unknown interactions that couple to mass between an optically levitated microsphere and a gold-coated silicon cantilever. The scale and geometry of the apparatus enable a search for new forces that appear at distances below 100  μm and which would have evaded previous searches due to screening mechanisms. The data are consistent with electrostatic backgrounds and place upper limits on the strength of new interactions at <0.1  fN in the geometry tested. For the specific example of a chameleon interaction with an inverse power law potential, these results exclude matter couplings β>5...
September 2, 2016: Physical Review Letters
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