keyword
MENU ▼
Read by QxMD icon Read
search

Blakemore

keyword
https://www.readbyqxmd.com/read/28428443/mechanisms-of-pinometostat-epz-5676-treatment-emergent-resistance-in-mll-rearranged-leukemia
#1
Carly T Campbell, Jessica N Haladyna, David A Drubin, Ty M Thomson, Michael J Maria, Taylor Yamauchi, Nigel J Waters, Edward J Olhava, Roy M Pollock, Jesse J Smith, Robert A Copeland, Stephen J Blakemore, Kathrin M Bernt, Scott R Daigle
DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its ectopic methylation of histones associated with well characterized leukemic genes.  Pinometostat (EPZ-5676), a selective inhibitor of DOT1L, is in clinical development in relapsed/refractory acute leukemia patients harboring rearrangements of the MLL gene. The observation of responses and subsequent relapses in the adult trial treating MLL-r patients motivated preclinical investigations into potential mechanisms of pinometostat treatment emergent resistance (TER) in cell lines confirmed to have MLL-r...
April 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28426091/distinguishing-between-homogeneous-and-heterogeneous-hydrogen-evolution-catalysis-with-molecular-cobalt-complexes
#2
David J Sconyers, James D Blakemore
Molecular proton-reduction catalysts can decompose under the acidic conditions required for hydrogen evolution, resulting in formation of secondary metal-containing materials. Using an electrochemical quartz crystal microbalance (EQCM), we report a new method for probing electrodeposition of catalytically active heterogeneous material from molecular precursors. The data collected suggest that EQCM can provide a direct measure of the homogeneity of molecular proton-reduction catalysts over short timescales.
April 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28420965/dopamine-a-modulator-of-circadian-rhythms-in-the-central-nervous-system
#3
REVIEW
Kirill S Korshunov, Laura J Blakemore, Paul Q Trombley
Circadian rhythms are daily rhythms that regulate many biological processes - from gene transcription to behavior - and a disruption of these rhythms can lead to a myriad of health risks. Circadian rhythms are entrained by light, and their 24-h oscillation is maintained by a core molecular feedback loop composed of canonical circadian ("clock") genes and proteins. Different modulators help to maintain the proper rhythmicity of these genes and proteins, and one emerging modulator is dopamine. Dopamine has been shown to have circadian-like activities in the retina, olfactory bulb, striatum, midbrain, and hypothalamus, where it regulates, and is regulated by, clock genes in some of these areas...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28399963/diagnostic-accuracy-of-the-xpert-%C3%A2-mtb-rif-cycle-threshold-level-to-predict-smear-positivity-a-meta-analysis
#4
B Lange, P Khan, G Kalmambetova, H A Al-Darraji, D Alland, U Antonenka, T Brown, M E Balcells, R Blakemore, C M Denkinger, K Dheda, H Hoffmann, A Kadyrov, N Lemaitre, M B Miller, V Nikolayevskyy, E N Ntinginya, N Ozkutuk, J J Palacios, E B Popowitch, J M Porcel, J Teo, G Theron, K Kranzer
SETTING: Xpert® MTB/RIF is the most widely used molecular assay for rapid diagnosis of tuberculosis (TB). The number of polymerase chain reaction cycles after which detectable product is generated (cycle threshold value, CT) correlates with the bacillary burden.OBJECTIVE To investigate the association between Xpert CT values and smear status through a systematic review and individual-level data meta-analysis. DESIGN: Studies on the association between CT values and smear status were included in a descriptive systematic review...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28391628/acceptance-of-peer-navigators-to-reduce-barriers-to-cervical-cancer-screening-and-treatment-among-women-with-hiv-infection-in-tanzania
#5
Alaya Koneru, Pauline E Jolly, Shaundra Blakemore, Renicha McCree, Nedra F Lisovicz, Eric A Aris, Thereza Mtesigwa, Safina Yuma, Julius D Mwaiselage
OBJECTIVE: To identify barriers to cervical cancer screening and treatment, and determine acceptance toward peer navigators (PNs) to reduce barriers. METHODS: A cross-sectional study was conducted among women with HIV infection aged 19 years or older attending HIV clinics in Dar es Salaam, Tanzania, between May and August 2012. Data for sociodemographic characteristics, barriers, knowledge and attitude toward cervical cancer screening and treatment, and PNs were collected by questionnaire...
April 8, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28338837/associations-of-leukocyte-telomere-length-with-aerobic-and-muscular-fitness-in-young-adults
#6
Dylan M Williams, Jessica L Buxton, Marko T Kantomaa, Tuija H Tammelin, Alexandra I F Blakemore, Marjo-Riitta Järvelin
Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952-5,205, varying by exposure-outcome analysis)...
April 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28321190/skeletal-dysplasias-growing-therapy-for-growing-bones
#7
REVIEW
Angie C Jelin, Elizabeth O'Hare, Karin Blakemore, Eric B Jelin, David Valle, Julie Hoover-Fong
Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management including pharmacologic treatment when available. Patients with severe skeletal dysplasias often have small chests with respiratory insufficiency or airway obstruction and require immediate intubation after birth...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28320701/alternative-method-of-tractioning-the-sengstaken-blakemore-tube
#8
Evelyn Patricia Murphy, Sean Michael O'Brien, Mark Regan
No abstract text is available yet for this article.
March 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28300402/synthesis-of-3-substituted-2-arylpyridines-via-cu-pd-catalyzed-decarboxylative-cross-coupling-of-picolinic-acids-with-hetero-aryl-halides
#9
Dagmar Hackenberger, Philip Weber, David C Blakemore, Lukas J Goossen
A decarboxylative cross-coupling of 3-substituted picolinic acids with (hetero)aryl halides is presented. In the presence of catalytic Cu2O and Pd(1,5-cyclooctadiene)Cl2 with 2-dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl as the ligand, both electron-rich and electron-deficient aryl bromides and chlorides as well as heteroaryl bromides were successfully coupled with various picolinate salts under mild conditions in yields up to 96%. This protocol provides an efficient entry to 2-(hetero)arylpyridines, an attractive substance class in drug discovery...
March 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28242797/development-of-the-cerebral-cortex-across-adolescence-a-multisample-study-of-inter-related-longitudinal-changes-in-cortical-volume-surface-area-and-thickness
#10
Christian K Tamnes, Megan M Herting, Anne-Lise Goddings, Rosa Meuwese, Sarah-Jayne Blakemore, Ronald E Dahl, Berna Güroğlu, Armin Raznahan, Elizabeth R Sowell, Eveline A Crone, Kathryn L Mills
Before we can assess and interpret how developmental changes in human brain structure relate to cognition, affect, and motivation, and how these processes are perturbed in clinical or at-risk populations, we must first precisely understand typical brain development and how changes in different structural components relate to each other. We conducted a multisample magnetic resonance imaging study to investigate the development of cortical volume, surface area, and thickness, as well as their inter-relationships, from late childhood to early adulthood (7-29 years) using four separate longitudinal samples including 388 participants and 854 total scans...
March 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28199125/one-pot-synthesis-of-%C3%AE-branched-n-acylamines-via-titanium-mediated-condensation-of-amides-aldehydes-and-organometallics
#11
Chunhui Dai, Julien Genovino, Bruce M Bechle, Matthew S Corbett, Chan Woo Huh, Colin R Rose, Jianmin Sun, Joseph S Warmus, David C Blakemore
A three-component, titanium-mediated synthesis of α-branched N-acylamines from commercial or readily accessible amides, aldehydes, and organometallic reagents is reported. The transformation proceeds under mild reaction conditions and tolerates a variety of functional groups (including nitrile, carbamate, olefin, basic amine, furan, and other sensitive heteroaromatics) to generate a large umbrella of α-branched N-acylamine products in high yields. The operationally practical procedure enables the use of this method in parallel chemical synthesis, a valuable feature that can facilitate the screening of bioactive molecules by medicinal chemists...
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28199120/one-pot-acid-catalyzed-ring-opening-cyclization-oxidation-of-aziridines-with-n-tosylhydrazones-access-to-1-2-4-triazines
#12
Lorène Crespin, Lorenzo Biancalana, Tobias Morack, David C Blakemore, Steven V Ley
A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening of the aziridine, giving access to a wide range of aminohydrazones, isolated with excellent yields. A "one-pot" procedure, combining the ring opening with a cyclization and an oxidation step, allows the preparation of diversified triazines in good yields.
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28183807/associations-of-participation-in-community-assets-with-health-related-quality-of-life-and-healthcare-usage-a-cross-sectional-study-of-older-people-in-the-community
#13
Luke A Munford, Mark Sidaway, Amy Blakemore, Matt Sutton, Pete Bower
BACKGROUND: Community assets are promoted as a way to improve quality of life and reduce healthcare usage. However, the quantitative impact of participation in community assets on these outcomes is not known. METHODS: We examined the association between participation in community assets and health-related quality of life (HRQoL) (EuroQol-5D-5L) and healthcare usage in 3686 individuals aged ≥65 years. We estimated the unadjusted differences in EuroQol-5D-5L scores and healthcare usage between participants and non-participants in community assets and then used multivariate regression to examine scores adjusted for sociodemographic and limiting long-term health conditions...
February 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28132629/a-challenging-year-of-change-lies-ahead
#14
(no author information available yet)
So, I'm back from a ten-month secondment spent primarily commissioning articles for all the RCNi specialist titles. I found the change of pace, the breadth of outlook and the increase of autonomy invigorating, but I am glad to be back as editor of Nursing Management. First of all, I'd like to thank Sophie Blakemore, now on maternity leave, for her excellent editorship of the journal since March last year; she's going to be a tough act to follow.
January 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27993132/performance-of-the-g4-xpert-%C3%A2-mtb-rif-assay-for-the-detection-of-mycobacterium-tuberculosis-and-rifampin-resistance-a-retrospective-case-control-study-of-analytical-and-clinical-samples-from-high-and-low-tuberculosis-prevalence-settings
#15
Nila J Dharan, Robert Blakemore, Alex Sloutsky, Devinder Kaur, Richard C Alexander, Minoo Ghajar, Kimberlee A Musser, Vincent E Escuyer, Marie-Claire Rowlinson, Susanne Crowe, Rafael Laniado-Laborin, Eloise Valli, Pamela Nabeta, Pamela Johnson, David Alland
BACKGROUND: The Xpert(®) MTB/RIF (Xpert) assay is a rapid PCR-based assay for the detection of Mycobacterium tuberculosis complex DNA (MTBc) and mutations associated with rifampin resistance (RIF). An updated version introduced in 2011, the G4 Xpert, included modifications to probe B and updated analytic software. METHODS: An analytical study was performed to assess Xpert detection of mutations associated with rifampin resistance in rifampin-susceptible and -resistant isolates...
December 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27991874/response-to-protocol-review-scenario-training-and-education
#16
Melodie Blakemore
No abstract text is available yet for this article.
December 19, 2016: Lab Animal
https://www.readbyqxmd.com/read/27979788/multivariate-dynamical-modelling-of-structural-change-during-development
#17
Gabriel Ziegler, Gerard R Ridgway, Sarah-Jayne Blakemore, John Ashburner, Will Penny
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems. The general approach enables modelling changes of states in multiple imaging biomarkers typically observed during brain development, plasticity, ageing and degeneration, e.g. regional gray matter volume of multiple regions of interest (ROIs). Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27890934/egr2-mutations-define-a-new-clinically-aggressive-subgroup-of-chronic-lymphocytic-leukemia
#18
E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist, F Damm
Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To study their prognostic impact, 2403 CLL patients were examined for mutations in the EGR2 hotspot region including a screening (n=1283) and two validation cohorts (UK CLL4 trial patients, n=366; CLL Research Consortium (CRC) patients, n=490). Targeted deep-sequencing of 27 known/postulated CLL driver genes was also performed in 38 EGR2-mutated patients to assess concurrent mutations...
January 3, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27843137/pi3k%C3%AE-inhibition-elicits-anti-leukemic-effects-through-bim-dependent-apoptosis
#19
M J Carter, K L Cox, S J Blakemore, A H Turaj, R J Oldham, L N Dahal, S Tannheimer, F Forconi, G Packham, M S Cragg
PI3Kδ plays pivotal roles in the maintenance, proliferation and survival of malignant B-lymphocytes. Although not curative, PI3Kδ inhibitors (PI3Kδi) demonstrate impressive clinical efficacy and, alongside other signaling inhibitors, are revolutionizing the treatment of hematological malignancies. However, only limited in vivo data are available regarding their mechanism of action. With the rising number of novel treatments, the challenge is to identify combinations that deliver curative regimes. A deeper understanding of the molecular mechanism is required to guide these selections...
December 20, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27833013/how-emotion-context-modulates-unconscious-goal-activation-during-motor-force-exertion
#20
Rebekah L Blakemore, Rémi Neveu, Patrik Vuilleumier
Priming participants with emotional or action-related concepts influences goal formation and motor force output during effort exertion tasks, even without awareness of priming information. However, little is known about neural processes underpinning how emotional cues interact with action (or inaction) goals to motivate (or demotivate) motor behaviour. In a novel functional neuroimaging paradigm, visible emotional images followed by subliminal action or inaction word primes were presented before participants performed a maximal force exertion...
February 1, 2017: NeuroImage
keyword
keyword
27384
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"