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https://www.readbyqxmd.com/read/29144972/building-bridges-through-science
#1
Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al'Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C Chang, Ta-Yuan Chang, Ami Citri, Hollis T Cline, Jesus M Cortes, Kathleen Cullen, Kellie Dean, José M Delgado-Garcia, Mathieu Desroches, John F Disterhoft, John E Dowling, Andreas Draguhn, Sherif F El-Khamisy, Abdeljabbar El Manira, S Ather Enam, Juan M Encinas, Asier Erramuzpe, José A Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W Pfaff, Bruno Poucet, Atta-Ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J Roberts, Serafim Rodrigues, Joshua R Sanes, Andreas T Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-García, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C Südhof, Jan Tønnesen, Mario Treviño, Basim M Uthman, J Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N Wiesel, Emre Yaksi, Ofer Yizhar, Larry J Young, Paul Young, Nasser H Zawia, José L Zugaza, Mazahir T Hasan
Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge" initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities.
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29121471/visible-light-mediated-annulation-of-electron-rich-alkenes-and-nitrogen-centered-radicals-from-n-sulfonylallylamines-construction-of-chloromethylated-pyrrolidine-derivatives
#2
Lorène Nathalie Sabine Crespin, Andreas Greb, David C Blakemore, Steven V Ley
A visible-light mediated annulation of N-sulfonylallylamines and olefins is reported. Rapid access to highly functionalized chloromethylated pyrrolidines can be achieved using mild conditions for the generation of nitrogen-centered radicals. Both a transition metal based catalyst and an organic dye can be used as photosensitizers, with 0.5 mol% loading. The reaction was found to be applicable to a large variety of electron-rich olefins.
November 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29117668/outcomes-of-patients-treated-with-sengstaken-blakemore-tube-for-uncontrolled-variceal-hemorrhage
#3
Ja Yun Choi, Yun Won Jo, Sang Soo Lee, Wan Soo Kim, Hye Won Oh, Cha Young Kim, Eun Young Yun, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Rock Bum Kim
Background/Aims: The aim of this study was to investigate the mortality, bleeding control rate, and their associated predictors in patients treated with Sengstaken-Blakemore (SB) tube for uncontrolled variceal hemorrhage associated with hemodynamic instability or failure of endoscopic treatment. Methods: The clinical data of 66 consecutive patients with uncontrolled variceal hemorrhage treated with SB tube at Gyeongsang National University Hospital from October 2010 to October 2015 were retrospectively analyzed...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29043813/catalyst-selection-facilitates-the-use-of-heterocyclic-sulfinates-as-general-nucleophilic-coupling-partners-in-palladium-catalyzed-coupling-reactions
#4
Tim Markovic, Benjamin N Rocke, David C Blakemore, Vincent Mascitti, Michael C Willis
A range of 5- and 6-membered heterocycle-derived sulfinates are shown to be effective nucleophilic coupling partners with aryl chlorides and bromides using Pd(0) catalysis. The use of optimal reaction conditions, specifically incorporating a P(t-Bu)2Me-derived Pd catalyst, allowed reactions to be performed at moderate temperatures and enabled the inclusion of a variety of sensitive functional groups. Challenging heterocyclic sulfinates, including pyrazine, pyridazine, pyrimidine, pyrazole, and imidazole, were all shown to perform well...
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29033788/zinc-as-a-neuromodulator-in-the-central-nervous-system-with-a-focus-on-the-olfactory-bulb
#5
REVIEW
Laura J Blakemore, Paul Q Trombley
The olfactory bulb (OB) is central to the sense of smell, as it is the site of the first synaptic relay involved in the processing of odor information. Odor sensations are first transduced by olfactory sensory neurons (OSNs) before being transmitted, by way of the OB, to higher olfactory centers that mediate olfactory discrimination and perception. Zinc is a common trace element, and it is highly concentrated in the synaptic vesicles of subsets of glutamatergic neurons in some brain regions including the hippocampus and OB...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29031469/gunslingers-poker-players-and-chickens-2-decision-making-under-physical-performance-pressure-in-subelite-athletes
#6
Beth L Parkin, Vincent Walsh
BACKGROUND: Having investigated the influence of acute physical exhaustion on decision-making in world-class elite athletes in Parkin et al. (2017), here a similar method is applied to subelite athletes. These subelite athletes were enrolled on a Team GB talent development program and were undergoing training for possible Olympic competition in 4-8 years. They differ from elite athletes examined previously according to expertise and age. While considered elite (Swann et al., 2015), the subelite athletes had approximately 8 years fewer sporting experience and were yet to obtain sustained success on the international stage...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29030403/new-blood-pressure-associated-loci-identified-in-meta-analyses-of-475%C3%A2-000-individuals
#7
Aldi T Kraja, James P Cook, Helen R Warren, Praveen Surendran, Chunyu Liu, Evangelos Evangelou, Alisa K Manning, Niels Grarup, Fotios Drenos, Xueling Sim, Albert Vernon Smith, Najaf Amin, Alexandra I F Blakemore, Jette Bork-Jensen, Ivan Brandslund, Aliki-Eleni Farmaki, Cristiano Fava, Teresa Ferreira, Karl-Heinz Herzig, Ayush Giri, Franco Giulianini, Megan L Grove, Xiuqing Guo, Sarah E Harris, Christian T Have, Aki S Havulinna, He Zhang, Marit E Jørgensen, AnneMari Käräjämäki, Charles Kooperberg, Allan Linneberg, Louis Little, Yongmei Liu, Lori L Bonnycastle, Yingchang Lu, Reedik Mägi, Anubha Mahajan, Giovanni Malerba, Riccardo E Marioni, Hao Mei, Cristina Menni, Alanna C Morrison, Sandosh Padmanabhan, Walter Palmas, Alaitz Poveda, Rainer Rauramaa, Nigel William Rayner, Muhammad Riaz, Ken Rice, Melissa A Richard, Jennifer A Smith, Lorraine Southam, Alena Stančáková, Kathleen E Stirrups, Vinicius Tragante, Tiinamaija Tuomi, Ioanna Tzoulaki, Tibor V Varga, Stefan Weiss, Andrianos M Yiorkas, Robin Young, Weihua Zhang, Michael R Barnes, Claudia P Cabrera, He Gao, Michael Boehnke, Eric Boerwinkle, John C Chambers, John M Connell, Cramer K Christensen, Rudolf A de Boer, Ian J Deary, George Dedoussis, Panos Deloukas, Anna F Dominiczak, Marcus Dörr, Roby Joehanes, Todd L Edwards, Tõnu Esko, Myriam Fornage, Nora Franceschini, Paul W Franks, Giovanni Gambaro, Leif Groop, Göran Hallmans, Torben Hansen, Caroline Hayward, Oksa Heikki, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Jarvelin, Sharon L R Kardia, Fredrik Karpe, Jaspal S Kooner, Timo A Lakka, Claudia Langenberg, Lars Lind, Ruth J F Loos, Markku Laakso, Mark I McCarthy, Olle Melander, Karen L Mohlke, Andrew P Morris, Colin N A Palmer, Oluf Pedersen, Ozren Polasek, Neil R Poulter, Michael A Province, Bruce M Psaty, Paul M Ridker, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Peter J Sever, Tea Skaaby, Jeanette M Stafford, John M Starr, Pim van der Harst, Peter van der Meer, Cornelia M van Duijn, Anne-Claire Vergnaud, Vilmundur Gudnason, Nicholas J Wareham, James G Wilson, Cristen J Willer, Daniel R Witte, Eleftheria Zeggini, Danish Saleheen, Adam S Butterworth, John Danesh, Folkert W Asselbergs, Louise V Wain, Georg B Ehret, Daniel I Chasman, Mark J Caulfield, Paul Elliott, Cecilia M Lindgren, Daniel Levy, Christopher Newton-Cheh, Patricia B Munroe, Joanna M M Howson
BACKGROUND: Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. METHODS AND RESULTS: Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29029933/highly-potent-and-selective-nav1-7-inhibitors-for-use-as-intravenous-agents-and-chemical-probes
#8
R Ian Storer, Andy Pike, Nigel A Swain, Aristos J Alexandrou, Bruce M Bechle, David C Blakemore, Alan D Brown, Neil A Castle, Matthew S Corbett, Neil J Flanagan, David Fengas, M Scott Johnson, Lyn H Jones, Brian E Marron, C Elizabeth Payne, David Printzenhoff, David J Rawson, Colin R Rose, Thomas Ryckmans, Jianmin Sun, Jonathan W Theile, Rubben Torella, Elaine Tseng, Joseph S Warmus
The discovery and selection of a highly potent and selective NaV1.7 inhibitor PF-06456384, designed specifically for intravenous infusion, is disclosed. Extensive in vitro pharmacology and ADME profiling followed by in vivo preclinical PK and efficacy model data are discussed. A proposed protein-ligand binding mode for this compound is also provided to rationalise the high levels of potency and selectivity over inhibition of related sodium channels. To further support the proposed binding mode, potent conjugates are described which illustrate the potential for development of chemical probes to enable further target evaluation...
November 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29024563/ligand-substituents-govern-the-efficiency-and-mechanistic-path-of-hydrogen-production-with-cp-rh-catalysts
#9
Wade Henke, Davide Lionetti, William Moore, Julie Hopkins, Victor Day, James Blakemore
We demonstrate that [Cp*Rh] complexes bearing substituted 2,2´-bipyridyl ligands are effective hydrogen-evolution catalysts (Cp* = η5-pentamethylcyclopentadienyl). Disubstitution (at the 4 and 4´ positions) of the bipyridyl ligand (namely -tBu, -H, and -CF3) modulates the catalytic overpotential, in part due to involvement of reduced ligand character in formally rhodium(I) intermediates. These reduced species are synthesized and isolated here; protonation results in formation of complexes bearing the unusual η4-pentamethylcyclopentadiene ligand, and the properties of these protonated intermediates further govern catalytic performance...
October 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29024095/trivalent-lewis-acidic-cations-govern-the-electronic-properties-and-stability-of-heterobimetallic-complexes-of-nickel
#10
Amit Kumar, Davide Lionetti, Victor Day, James Blakemore
Assembly of heterobimetallic complexes is synthetically challenging due to the propensity of ditopic ligands to bind metals unselectively. Here, we employ a novel divergent approach for selective preparation of a variety of bimetallic complexes within a ditopic macrocyclic ligand platform. In our approach, nickel is readily coordinated to a Schiff-base cavity, and then a range of redox-inactive cations (M = Na+, Ca2+, Nd3+, and Y3+) are installed in a pendant crown ether-like site. This modular strategy allows access to complexes with the highly Lewis-acidic trivalent cations Nd3+ and Y3+, a class of compounds that were previously inaccessible...
October 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29018042/gwas-on-prolonged-gestation-post-term-birth-analysis-of-successive-finnish-birth-cohorts
#11
William Schierding, Jisha Antony, Ville Karhunen, Marja Vääräsmäki, Steve Franks, Paul Elliott, Eero Kajantie, Sylvain Sebert, Alex Blakemore, Julia A Horsfield, Marjo-Riitta Järvelin, Justin M O'Sullivan, Wayne S Cutfield
BACKGROUND: Gestation is a crucial timepoint in human development. Deviation from a term gestational age correlates with both acute and long-term adverse health effects for the child. Both being born preterm and post-term, that is, having short and long gestational ages, are heritable and influenced by the prenatal and perinatal environment. Despite the obvious heritable component, specific genetic influences underlying differences in gestational age are poorly understood. METHODS: We investigated the genetic architecture of gestational age in 9141 individuals, including 1167 born post-term, across two Northern Finland cohorts born in 1966 or 1986...
October 10, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28984993/total-synthesis-of-13-c-2-13-c-3-and-13-c-5-isotopomers-of-xanthohumol-the-principal-prenylflavonoid-from-hops
#12
Duncan C Ellinwood, Mohamed F El-Mansy, Layhna S Plagmann, Jan F Stevens, Claudia S Maier, Adrian F Gombart, Paul R Blakemore
Xanthohumol [(E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated flavonoid from hops, has a complex bioactivity profile and (13) C-labelled isotopomers of this compound are of potential use as molecular probes and as analytical standards to study metabolism and mode-of-action. 1,3-[(13) C]2 -Xanthohumol was prepared by an adaptation of the total synthesis of Khupse and Erhardt in 7 steps and 5.7% overall yield from phloroglucinol by a route incorporating a cascade Claisen-Cope rearrangement to install the 3´-prenyl moiety from a 5´-prenyl aryl ether and an aldol condensation between 1-[(13) C]-2´,4´-bis(benzyloxymethyloxy)-6´-methoxy-3´-(3-methylbuten-2-yl)acetophenone and 1´-[(13) C]-4-(methoxymethyloxy)benzaldehyde...
October 6, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28936330/pyridine-sulfinates-as-general-nucleophilic-coupling-partners-in-palladium-catalyzed-cross-coupling-reactions-with-aryl-halides
#13
Tim Markovic, Benjamin N Rocke, David C Blakemore, Vincent Mascitti, Michael C Willis
Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon-carbon bonds in the pharmaceutical industry, the Suzuki-Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfinates, a cross-coupling process of unrivalled scope and utility is realized...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28894287/prognostic-significance-of-high-gfi1-expression-in-aml-of-normal-karyotype-and-its-association-with-a-flt3-itd-signature
#14
Giacomo Volpe, David S Walton, David E Grainger, Carl Ward, Pierre Cauchy, Daniel Blakemore, Daniel J L Coleman, Peter N Cockerill, Paloma Garcia, Jon Frampton
Growth Factor Independence 1 (GFI1) is a transcriptional repressor that plays a critical role during both myeloid and lymphoid haematopoietic lineage commitment. Several studies have demonstrated the involvement of GFI1 in haematological malignancies and have suggested that low expression of GFI1 is a negative indicator of disease progression for both myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study, we have stratified AML patients into those defined as having a normal karyotype (CN-AML)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868751/reductive-coupling-of-acrylates-with-ketones-and-ketimines-by-a-nickel-catalyzed-transfer-hydrogenative-strategy
#15
Craig S Buxton, David C Blakemore, John F Bower
Nickel-catalyzed coupling of benzyl acrylates with activated ketones and imines provides γ-butyrolactones and lactams, respectively. The benzyl alcohol byproduct released during the lactonization/lactamization event is relayed to the next cycle where it serves as the reductant for C-C bond formation. This strategy represents a conceptually unique approach to transfer-hydrogenative C-C bond formation, thus providing examples of reductive heterocyclizations where hydrogen embedded within an alcohol leaving group facilitates turnover...
October 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28864118/the-impacts-of-institutional-child-sexual-abuse-a-rapid-review-of-the-evidence
#16
Tamara Blakemore, James Leslie Herbert, Fiona Arney, Samantha Parkinson
While awareness of institutional child sexual abuse has grown in recent years, there remains limited understanding of its occurrence and outcomes as a distinct form of abuse. Drawing on research commissioned by the Australian Royal Commission into Institutional Responses to Child Sexual Abuse, this article presents a rapid review of available evidence on the impacts of institutional abuse on victim/survivors. Literature searches identified 75 sources spanning international peer reviewed work and reports to Government that document or quantify the impacts of mostly historical child sexual abuse occurring in religious, educational, sporting and residential or out-of-home care settings...
August 31, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28862433/role-of-ligand-protonation-in-dihydrogen-evolution-from-a-pentamethylcyclopentadienyl-rhodium-catalyst
#17
Samantha I Johnson, Harry B Gray, James D Blakemore, William A Goddard
Recent work has shown that Cp*Rh(bpy) [Cp* = pentamethylcyclopentadienyl, bpy = 2,2'- bipyridine] undergoes endo protonation at the [Cp*] ligand in the presence of weak acid (Et3NH(+); pKa = 18.8 in MeCN). Upon exposure to stronger acid (e.g., DMFH(+); pKa = 6.1), hydrogen is evolved with unity yield. Here, we study the mechanisms by which this catalyst evolves dihydrogen using density functional theory (M06) with polarizable continuum solvation. The calculations show that the complex can be protonated by weak acid first at the metal center with a barrier of 3...
September 1, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28854922/barriers-and-facilitators-in-accessing-dementia-care-by-ethnic-minority-groups-a-meta-synthesis-of-qualitative-studies
#18
Cassandra Kenning, Gavin Daker-White, Amy Blakemore, Maria Panagioti, Waquas Waheed
BACKGROUND: It is estimated that there are about 25,000 people from UK ethnic minority groups with dementia. It is clear that there is an increasing need to improve access to dementia services for all ethnic groups to ensure that everyone has access to the same potential health benefits. The aim was to systematically review qualitative studies and to perform a meta-synthesis around barriers and facilitators to accessing care for dementia in ethnic minorities. METHODS: Databases were searched to capture studies on barriers and facilitators to accessing care for dementia in ethnic minorities...
August 30, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28851433/systematic-review-of-effectiveness-of-universal-self-regulation-based-interventions-and-their-effects-on-distal-health-and-social-outcomes-in-children-and-adolescents-review-protocol
#19
Anuja Pandey, Daniel Hale, Anne-Lise Goddings, Sarah-Jayne Blakemore, Russell Viner
BACKGROUND: Growing evidence suggests that childhood and adolescence self-regulation contributes to multiple health, educational and social outcomes. Considering the potential impact of self-regulation skills on improved life chances in conjunction with evidence suggesting that self-regulation can be modified by interventions, there is a need to identify interventions which are most effective in improving childhood and adolescence self-regulation. The present systematic review was designed to determine the effectiveness of universal interventions focused on enhancing the self-regulation of children and adolescents...
August 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28834041/formation-of-olefins-by-eliminative-dimerization-and-eliminative-cross-coupling-of-carbenoids-a-stereochemical-exercise
#20
REVIEW
Paul R Blakemore, Reinhard W Hoffmann
Two carbenoids combine to generate an olefin by a mechanism involving formation of an ate complex, 1,2-metalate rearrangement, and β-elimination. As each stage of this eliminative coupling is stereospecific, the overall stereochemical outcome can be understood and, in principle fully controlled, providing that the absolute stereochemical configurations of the reacting carbenoid species are defined. In contrast to traditional alkene syntheses, the eliminative cross-coupling of carbenoids offers a connective approach to olefins capable of precisely targeting a given isomer regardless of the nature of the features distinguishing the isomers...
August 22, 2017: Angewandte Chemie
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