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REVIEW
Connie S Cole, Jessica Roydhouse, Regina M Fink, Mustafa Ozkaynak, Joan G Carpenter, Evan Plys, Shaowei Wan, Cari R Levy
OBJECTIVES: Despite common use of palliative care screening tools in other settings, the performance of these tools in the nursing home has not been well established; therefore, the purpose of this review is to (1) identify palliative care screening tools validated for nursing home residents and (2) critically appraise, compare, and summarize the quality of measurement properties. DESIGN: Systematic review of measurement properties consistent with Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines...
May 2023: Journal of the American Medical Directors Association
#22
JOURNAL ARTICLE
William S Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D Berry, Catherine Anderson, Milan R Amin, Michael S Benninger, Joel H Blumin, Jonathan M Bock, Paul C Bryson, Paul F Castellanos, Matthew S Clary, Seth M Cohen, Brianna K Crawley, Seth H Dailey, James J Daniero, Alessandro de Alarcon, Donald T Donovan, Eric S Edell, Dale C Ekbom, Daniel S Fink, Ramon A Franco, Catherine Gaelyn Garrett, Elizabeth A Guardiani, Alexander T Hillel, Henry T Hoffman, Norman D Hogikyan, Rebecca J Howell, Michael M Johns, Jan L Kasperbauer, Sid M Khosla, Cheryl Kinnard, Robbi A Kupfer, Alexander J Langerman, Robert J Lentz, Robert R Lorenz, David G Lott, Samir S Makani, Fabien Maldonado, Laura Matrka, Andrew J McWhorter, Albert L Merati, Matthew Mori, James L Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N Postma, Lindsay S Reder, Sarah L Rohde, Brent E Richardson, Otis B Rickman, Clark A Rosen, Matthew Rohlfing, Michael J Rutter, Guri S Sandhu, Joshua S Schindler, Glenn Todd Schneider, Rupali N Shah, Andrew G Sikora, Robert J Sinard, Marshall E Smith, Libby J Smith, Ahmed M S Soliman, Sigríður Sveinsdóttir, David Veivers, Sunil P Verma, Paul M Weinberger, Philip A Weissbrod, Christopher T Wootten, Yu Shyr, David O Francis, Alexander Gelbard
The North American Airway Collaborative (NoAAC) previously published a 3-year multi-institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re-enrolled for 2 additional years and followed using the prespecified published protocol. Consistent with prior data, prospective observation of 487 iSGS patients for 5 years showed treatment effectiveness differed by modality...
June 2023: Otolaryngology—Head and Neck Surgery
#23
MULTICENTER STUDY
Stefanie T Jost, Agni Konitsioti, Philipp A Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela Dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R Fink, Monty Silverdale, Rubens G Cury, Erich T Fonoff, Angelo Antonini, K Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S Dafsari
INTRODUCTION: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD. METHODS: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD)...
April 2023: Parkinsonism & related Disorders
#24
JOURNAL ARTICLE
Jennifer L Ridgeway, Erin O Wissler Gerdes, Andrew Dodge, Chad P Liedl, Michael B Juntunen, Wendy J S Sundt, Amy Glasgow, Michelle A Lampman, Angela L Fink, Sara B Severson, Grace Lin, Richard R Sampson, Robert P Peterson, Brian M Murley, Aaron B Klassen, Anuradha Luke, Paul A Friedman, Tamara E Buechler, James S Newman, Rozalina G McCoy
BACKGROUND: New patient-centered models of care are needed to individualize care and reduce high-cost care, including emergency department (ED) visits and hospitalizations for low- and intermediate-acuity conditions that could be managed outside the hospital setting. Community paramedics (CPs) have advanced training in low- and high-acuity care and are equipped to manage a wide range of health conditions, deliver patient education, and address social determinants of health in the home setting...
February 20, 2023: Trials
#25
JOURNAL ARTICLE
Shaoxuan Ren, Eric W Lees, Camden Hunt, Andrew Jewlal, Yongwook Kim, Zishuai Zhang, Benjamin A W Mowbray, Arthur G Fink, Luke Melo, Edward R Grant, Curtis P Berlinguette
Here, we detail how the catalytic behavior of immobilized molecular electrocatalysts for the CO2 reduction reaction (CO2 RR) can be impacted by catalyst aggregation. Operando Raman spectroscopy was used to study the CO2 RR mediated by a layer of cobalt phthalocyanine (CoPc) immobilized on the cathode of an electrochemical flow reactor. We demonstrate that during electrolysis, the oxidation state of CoPc in the catalyst layer is dependent upon the degree of catalyst aggregation. Our data indicate that immobilized molecular catalysts must be dispersed on conductive supports to mitigate the formation of aggregates and produce meaningful performance data...
February 17, 2023: Journal of the American Chemical Society
#26
JOURNAL ARTICLE
Amadeus T Heinz, Friso G J Calkoen, Alexander Derbich, Lea Miltner, Christian Seitz, Michaela Doering, Christiane Braun, Daniel Atar, Michael Schumm, Florian Heubach, Anne-Marie Arendt, Ansgar Schulz, Friedhelm R Schuster, Roland Meisel, Brigitte Strahm, Juergen Finke, Beatrice Heineking, Susanne Stetter, Gerda Silling, Daniel Stachel, Bernd Gruhn, Klaus-Michael Debatin, Juergen Foell, Johannes H Schulte, Wilhelm Woessmann, Christine Mauz-Körholz, Johanna Tischer, Tobias Feuchtinger, Rupert Handgretinger, Peter Lang
Therapy resistant viral reactivations significantly contribute to mortality after hematopoietic stem cell transplantation. Adoptive cellular therapy with virus-specific T cells has shown efficacy in various single center trials. However, scalability of this therapy is hampered by laborious production methods. In this study we describe the in-house production of virus-specific T cells (VST) in a closed system (CliniMACS Prodigy® system by Miltenyi Biotec). In addition, we report the efficacy in 26 patients with viral disease post HSCT in a retrospective analysis (ADV n=7, CMV n=8, EBV n=4, multi-viral n=7)...
February 16, 2023: Haematologica
#27
JOURNAL ARTICLE
Martin K R Svačina, Alina Sprenger-Svačina, Anastasia Tsakmaklis, Alina M Rüb, Ines Klein, Hauke Wüstenberg, Gereon R Fink, Helmar C Lehmann, Maria J G T Vehreschild, Fedja Farowski
BACKGROUND AND PURPOSE: The gut microbiome is involved in autoimmunity. Data on its composition in chronic inflammatory demyelinating polyneuropathy (CIDP), the most common chronic autoimmune disorder of peripheral nerves, are currently lacking. METHODS: In this monocentric exploratory pilot study, stool samples were prospectively collected from 16 CIDP patients (mean age 58 ± 10 years, 25% female) before and 1 week after administration of intravenous immunoglobulin (IVIg)...
January 18, 2023: European Journal of Neurology
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JOURNAL ARTICLE
Rochelle K van der Merwe, Jacob A Nadel, Della Copes-Finke, Sean Pawelko, Jesse S Scott, Marwan Ghanem, M Fox, Caroline Morehouse, Robert McLaughlin, Charlie Maddox, Ruth Albert-Lyons, Golara Malaki, Virginia Groce, Alaina Turocy, Nada Aggadi, Xin Jin, Christopher D Howard
Behavioural flexibility is key to survival in a dynamic environmentWhile flexible, goal-directed behaviours are initially dependent on dorsomedial striatum, they become dependent on lateral striatum as behaviours become inflexible. Similarly, lesions of dopamine terminals in lateral striatum disrupt the development of inflexible habits. This work suggests that dopamine release in lateral striatum may drive inflexible behaviours, though few studies have investigated a causative role of subpopulations of striatal dopamine terminals in reversal learning, a measure of flexibility...
January 8, 2023: European Journal of Neuroscience
#29
JOURNAL ARTICLE
R Purtschert, A J Love, W Jiang, Z-T Lu, G-M Yang, S Fulton, D Wohling, P Shand, W Aeschbach-Hertig, L Broder, P Müller, Y Tosaki
Understanding the age distribution of groundwater can provide information on both the recharge history as well as the geochemical evolution of groundwater flow systems. Of the few candidates available that can be used to date old groundwater, 81 Kr shows the most promise because its input function is constant through time and there are less sources and sinks to complicate the dating procedure in comparison to traditional tracers such as 36 Cl and 4 He. In this paper we use 81 Kr in a large groundwater basin to obtain a better understanding of the residence time distribution of an unconfined-confined aquifer system...
November 5, 2022: Science of the Total Environment
#30
REVIEW
Steven Char, Max Y Jin, Vinicius Tieppo Francio, Nasir Hussain, Eric J Wang, Mahmoud Morsi, Vwaire Orhurhu, Larry J Prokop, Adam Fink, Ryan S D'Souza
Peripheral nerve stimulation (PNS) has been utilized for over 50 years with accumulating evidence of efficacy in a variety of chronic pain conditions. The level and strength of evidence supporting the use of PNS for peripheral neuropathic pain remains unclear. The purpose of this review is to synthesize data from prospective studies on the efficacy of PNS for neuropathic pain as it pertains to pain intensity, neurological deficits/neuropathy (e.g., weakness, sensory deficits, gait/balance), and other secondary outcomes (quality of life, satisfaction, emotional functioning, and adverse events)...
October 17, 2022: Biomedicines
#31
Taylor G Lackey, James R Duffy, Carrie Marshall, Daniel S Fink
We report a case of isolated laryngeal mucormycosis in a patient who presented in diabetic ketoacidosis (DKA). The patient was managed with antifungal therapy and eventual total laryngectomy. To our knowledge, this is the first case presented of mucormycosis with isolated laryngeal involvement.
October 2022: Clinical Case Reports
#32
JOURNAL ARTICLE
Thanh N Nguyen, Muhammad M Qureshi, Piers Klein, Hiroshi Yamagami, Robert Mikulik, Anna Czlonkowska, Mohamad Abdalkader, Petra Sedova, Anvitha Sathya, Hannah C Lo, Ossama Yassin Mansour, Husitha Reddy Vanguru, Emilie Lesaine, Georgios Tsivgoulis, Aaron I Loochtan, Jelle Demeestere, Ken Uchino, Violiza Inoa, Nitin Goyal, Andreas Charidimou, James E Siegler, Shadi Yaghi, Diana Aguiar de Sousa, Mahmoud H Mohammaden, Diogo C Haussen, Espen Saxhaug Kristoffersen, Virginia Pujol Lereis, Sergio Daniel Scollo, Bruce C V Campbell, Alice Ma, James Orton Thomas, Mark W Parsons, Shaloo Singhal, Lee-Anne Slater, Rodrigo Tomazini Martins, Chris Enzinger, Thomas Gattringer, Aminur Rahman, Thomas Bonnet, Noemie Ligot, Sylvie De Raedt, Robin Lemmens, Peter Vanacker, Fenne Vandervorst, Adriana Bastos Conforto, Raquel C T Hidalgo, Luciana de Oliveira Neves, Rodrigo Targa Martins, Daissy Liliana Mora Cuervo, Leticia C Rebello, Igor Bessa Santiago, Isabelle Lameirinhas da Silva, Teodora Sakelarova, Rosen Kalpachki, Filip Alexiev, Luciana Catanese, Elena Adela Cora, Mayank Goyal, Michael D Hill, Michael E Kelly, Houman Khosravani, Pascale Lavoie, Lissa Peeling, Aleksandra Pikula, Rodrigo Rivera, Hui-Sheng Chen, Yimin Chen, Xiaochuan Huo, Zhongrong Miao, Shuiquan Yang, Marina Roje Bedekovic, Marina Bralic, Hrvoje Budincevic, Angel Basilio Corredor-Quintero, Osvaldo E Lara-Sarabia, Martin Cabal, Dusan Tenora, Petr Fibrich, Roman Herzig, Helena Hlaváčová, Emanuela Hrabanovska, David Hlinovsky, Lubomir Jurak, Jana Kadlcikova, Igor Karpowicz, Lukas Klecka, Martin Kovar, David Lauer, Jiri Neumann, Hana Palouskova, Martin Reiser, Petra Rekova, Vladimir Rohan, Ondrej Skoda, Miroslav Škorňa, Lenka Sobotková, Martin Sramek, Lenka Zakova, Hanne Christensen, Nicolas Drenck, Helle Klingenberg Iversen, Thomas Clement Truelsen, Troels Wienecke, Khalid Sobh, Pauli Ylikotila, Kemal Alpay, Daniel Strbian, Patricia Bernady, Philippe Casenave, Maria Dan, Jean-Marc Faucheux, Jean-Christophe Gentric, Elsa Magro, Candice Sabben, Peggy Reiner, Francois Rouanet, Ferdinand O Bohmann, Stefan Boskamp, Joshua Mbroh, Simon Nagel, Christian H Nolte, Peter A Ringleb, Michael Rosenkranz, Sven Poli, Götz Thomalla, Theodoros Karapanayiotides, Ioanna Koutroulou, Odysseas Kargiotis, Lina Palaiodimou, Jose Dominguo Barrientos Guerra, Vikram Huded, Bindu Menon, Shashank Nagendra, Chintan Prajapati, P N Sylaja, Nyoman Angga Krishna Pramana, Achmad Firdaus Sani, Abdoreza Ghoreishi, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Tariq Abu Raya, Shani Avnery Kalmanovich, Levite Ronen, Sergiu Ionut Sabetay, Maurizio Acampa, Alessandro Adami, Lucio Castellan, Marco Longoni, Raffaele Ornello, Leonardo Renieri, Claudia Rolla Bigliani, Michele Romoli, Simona Sacco, Andrea Salmaggi, Davide Sangalli, Andrea Zini, Ryosuke Doijiri, Hiroki Fukuda, Toshiyuki Fujinaka, Kyohei Fujita, Hirotoshi Imamura, Nobuyuki Sakai, Takuya Kanamaru, Naoto Kimura, Ryuhei Kono, Kosuke Miyake, Manabu Sakaguchi, Kenichiro Sakai, Kazutaka Sonoda, Kenichi Todo, Fumio Miyashita, Naoki Tokuda, Yuji Matsumaru, Shoji Matsumoto, Nobuyuki Ohara, Seigo Shindo, Yohei Takenobu, Takeshi Yoshimoto, Kazunori Toyoda, Takeshi Uwatoko, Yoshiki Yagita, Takehiro Yamada, Nobuaki Yamamoto, Ryoo Yamamoto, Yukako Yazawa, Yuri Sugiura, Peter Kuria Waweru, Jang-Hyun Baek, Si Baek Lee, Kwon-Duk Seo, Sung-Il Sohn, Anita Ante Arsovska, Yong Chieh Chan, Wan Asyraf Wan Zaidi, Ainul Syahrilfazli Jaafar, Fernando Gongora-Rivera, Manuel Martinez-Marino, Adrian Infante-Valenzuela, Stanislav Groppa, Pavel Leahu, Jonathan M Coutinho, Leon A Rinkel, Diederik W J Dippel, Dianne H K van Dam-Nolen, Annemarei Ranta, Teddy Y Wu, Tajudeen Temitayo Adebayo, Abiodun H Bello, Ernest Okwundu Nwazor, Taofiki Ajao Sunmonu, Kolawole Wasiu Wahab, Ole Morten Ronning, Else Charlotte Sandset, Amal M Al Hashmi, Saima Ahmad, Umair Rashid, Liliana Rodriguez-Kadota, Miguel Ángel Vences, Patrick Matic Yalung, Jon Stewart Hao Dy, Maria Carissa Pineda-Franks, Christian Oliver Co, Waldemar Brola, Aleksander Debiec, Malgorzata Dorobek, Michal Adam Karlinski, Beata M Labuz-Roszak, Anetta Lasek-Bal, Halina Sienkiewicz-Jarosz, Jacek Staszewski, Piotr Sobolewski, Marcin Wiacek, Justyna Zielinska-Turek, Andre Pinho Araujo, Mariana Rocha, Pedro Castro, Vitor Tedim Cruz, Paulo Venancio Ferreira, Patricia Ferreira, Ana Paiva Nunes, Luisa Fonseca, João Pedro Marto, Teresa Pinho E Melo, Miguel Rodrigues, M Luis Silva, Adela Dimitriade, Cristian Falup-Pecurariu, May Adel Hamid, Narayanaswamy Venketasubramanian, Georgi Krastev, Miroslav Mako, Oscar Ayo-Martin, Francisco Hernández-Fernández, Jordi Blasco, Alejandro Rodríguez-Vázquez, Antonio Cruz-Culebras, Francisco Moniche, Joan Montaner, Soledad Perez-Sanchez, María Jesús García Sánchez, Marta Guillán Rodríguez, Katarina Jood, Annika Nordanstig, Michael V Mazya, Tiago T P Moreira, Gianmarco Bernava, Morin Beyeler, Manuel Bolognese, Emmanuel Carrera, Tomas Dobrocky, Grzegorz Marek Karwacki, Emanuela Keller, Chang Yang Hsieh, Surawan Boonyakarnkul, Anchalee Churojana, Ozlem Aykac, Atilla Ã-Zcan Ozdemir, Arsida Bajrami, Songul Senadim, Syed Irteza Hussain, Seby John, Soma Banerjee, Joseph Kwan, Kailash Krishnan, Robert Lenthall, Ashok Matthews, Ken Wong, Liqun Zhang, Dorothea Altschul, Kaiz S Asif, Zeelalem Bahiru, Kristine Below, José Biller, Sean Ruland, Saqib A Chaudry, Michael Chen, Alex Chebl, Jackie Cibulka, Leon Cistrunk, Judith Clark, Marco Colasurdo, Alexandra Czap, Adam de Havenon, Salvatore D'Amato, Sushrut Dharmadhikari, Kasey B Grimmett, Adam A Dmytriw, Mark R Etherton, Chizoba Ezepue, Mudassir Farooqui, Steven K Feske, Lauren Fink, Ulviyya Gasimova, Amy K Guzik, Maryam Hakemi, Majesta Hovingh, Muhib Khan, Dinesh Jillela, Peter T Kan, Rakesh Khatri, Ayaz M Khawaja, Naim N Khoury, Nicole L Kiley, Benny S Kim, Murali K Kolikonda, Anna Luisa Kuhn, Stephanie Lara, Guillermo Linares, Italo Linfante, Timothy G Lukovits, Sarah Lycan, Shailesh S Male, Laith Maali, John Mancin, Hesham Masoud, Ghada A Mohamed, Andre Monteiro, Fadi Nahab, Krishna Nalleballe, Santiago Ortega-Gutierrez, Ajit S Puri, Yazan Radaideh, Rahul H Rahangdale, Ansaar Rai, Pankajavalli Ramakrishnan, Aravind B Reddy, Diana M Rojas-Soto, Jose Rafael Romero, Natalia S Rost, Aaron Rothstein, Setareh Salehi Omran, Sunil A Sheth, Adnan H Siddiqui, Amy K Starosciak, Nicholas E Tarlov, Robert A Taylor, Michael J Wang, Jared Wolfe, Ka-Ho Wong, Huynh Vu Le, Quy Viet Nguyen, Thong Nhu Pham, Trung Thanh Nguyen, Hoang Thi Phan, Mai Duy Ton, Urs Fischer, Patrik Michel, Davide Strambo, Sheila O Martins, Osama O Zaidat, Raul G Nogueira
BACKGROUND AND OBJECTIVES: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020)...
January 24, 2023: Neurology
#33
JOURNAL ARTICLE
Brian D Reed, Michael J Meyer, Valentin Abramzon, Omer Ad, Omer Ad, Pat Adcock, Faisal R Ahmad, Gün Alppay, James A Ball, James Beach, Dominique Belhachemi, Anthony Bellofiore, Michael Bellos, Juan Felipe Beltrán, Andrew Betts, Mohammad Wadud Bhuiya, Kristin Blacklock, Robert Boer, David Boisvert, Norman D Brault, Aaron Buxbaum, Steve Caprio, Changhoon Choi, Thomas D Christian, Robert Clancy, Joseph Clark, Thomas Connolly, Kathren Fink Croce, Richard Cullen, Mel Davey, Jack Davidson, Mohamed M Elshenawy, Michael Ferrigno, Daniel Frier, Saketh Gudipati, Stephanie Hamill, Zhaoyu He, Sharath Hosali, Haidong Huang, Le Huang, Ali Kabiri, Gennadiy Kriger, Brittany Lathrop, An Li, Peter Lim, Stephen Liu, Feixiang Luo, Caixia Lv, Xiaoxiao Ma, Evan McCormack, Michele Millham, Roger Nani, Manjula Pandey, John Parillo, Gayatri Patel, Douglas H Pike, Kyle Preston, Adeline Pichard-Kostuch, Kyle Rearick, Todd Rearick, Marco Ribezzi-Crivellari, Gerard Schmid, Jonathan Schultz, Xinghua Shi, Badri Singh, Nikita Srivastava, Shannon F Stewman, T R Thurston, T R Thurston, Philip Trioli, Jennifer Tullman, Xin Wang, Yen-Chih Wang, Eric A G Webster, Zhizhuo Zhang, Jorge Zuniga, Smita S Patel, Andrew D Griffiths, Antoine M van Oijen, Michael McKenna, Matthew D Dyer, Jonathan M Rothberg
Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity. Here, we demonstrate single-molecule protein sequencing using a dynamic approach in which single peptides are probed in real time by a mixture of dye-labeled N-terminal amino acid recognizers and simultaneously cleaved by aminopeptidases. We annotate amino acids and identify the peptide sequence by measuring fluorescence intensity, lifetime, and binding kinetics on an integrated semiconductor chip...
October 14, 2022: Science
#34
JOURNAL ARTICLE
S Latarnik, J Stahl, S Vossel, C Grefkes, G R Fink, P H Weiss
BACKGROUND: This study aims to characterize the impact of apraxia and visuospatial neglect on stroke patients' cognitive and functional outcomes during early rehabilitation. Prior work implies an unfavorable effect of visuospatial neglect on rehabilitation; however, previous findings remain ambiguous and primarily considered long-term effects. Even less is known about the impact of apraxia on rehabilitation outcomes. Although clinicians agree on the significance of the first few weeks after stroke for the course of rehabilitation, studies exploring the impact of neglect and apraxia in this early rehabilitation period remain scarce...
September 26, 2022: Neurological research and practice
#35
JOURNAL ARTICLE
Haley Sanderson, Kristen L Gray, Alexander Manuele, Finlay Maguire, Amjad Khan, Chaoyue Liu, Chandana Navanekere Rudrappa, John H E Nash, James Robertson, Kyrylo Bessonov, Martins Oloni, Brian P Alcock, Amogelang R Raphenya, Tim A McAllister, Sharon J Peacock, Kathy E Raven, Theodore Gouliouris, Andrew G McArthur, Fiona S L Brinkman, Ryan C Fink, Rahat Zaheer, Robert G Beiko
Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats...
September 2022: Microbial Genomics
#36
MULTICENTER STUDY
Ericka L Fink, Patrick M Kochanek, Ashok Panigrahy, Sue R Beers, Rachel P Berger, Hülya Bayir, Jose Pineda, Christopher Newth, Alexis A Topjian, Craig A Press, Aline B Maddux, Frederick Willyerd, Elizabeth A Hunt, Ashley Siems, Melissa G Chung, Lincoln Smith, Jesse Wenger, Lesley Doughty, J Wesley Diddle, Jason Patregnani, Juan Piantino, Karen Hallermeier Walson, Binod Balakrishnan, Michael T Meyer, Stuart Friess, David Maloney, Pamela Rubin, Tamara L Haller, Amery Treble-Barna, Chunyan Wang, Robert R S B Clark, Anthony Fabio
IMPORTANCE: Families and clinicians have limited validated tools available to assist in estimating long-term outcomes early after pediatric cardiac arrest. Blood-based brain-specific biomarkers may be helpful tools to aid in outcome assessment. OBJECTIVE: To analyze the association of blood-based brain injury biomarker concentrations with outcomes 1 year after pediatric cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS: The Personalizing Outcomes After Child Cardiac Arrest multicenter prospective cohort study was conducted in pediatric intensive care units at 14 academic referral centers in the US between May 16, 2017, and August 19, 2020, with the primary investigators blinded to 1-year outcomes...
September 1, 2022: JAMA Network Open
#37
JOURNAL ARTICLE
Shivanshu Awasthi, G Daniel Grass, Javier Torres-Roca, Peter A S Johnstone, Julio Pow-Sang, Jasreman Dhillon, Jong Park, Robert J Rounbehler, Elai Davicioni, Alex Hakansson, Yang Liu, Angelina K Fink, Amanda DeRenzis, Jordan H Creed, Michael Poch, Roger Li, Brandon Manley, Daniel Fernandez, Arash Naghavi, Kenneth Gage, Grace Lu-Yao, Evangelia Katsoulakis, Ryan J Burri, Andrew Leone, Cesar E Ercole, Joshua D Palmer, Neha Vapiwala, Curtiland Deville, Timothy R Rebbeck, Adam P Dicker, William Kelly, Kosj Yamoah
BACKGROUND: Personalized genomic classifiers have transformed the management of prostate cancer (PCa) by identifying the most aggressive subsets of PCa. Nevertheless, the performance of genomic classifiers to risk-classify African American men is thus far lacking in a prospective setting. METHODS: This is a prospective study of the Decipher genomic classifier for NCCN low- and intermediate-risk PCa. Study eligible non-African American men were matched to African American men...
September 2, 2022: Journal of the National Cancer Institute
#38
JOURNAL ARTICLE
Neethi P Pinto, Aline B Maddux, Leslie A Dervan, Alan G Woodruff, Jessica M Jarvis, Sholeen Nett, Elizabeth Y Killien, Robert J Graham, Karen Choong, Peter M Luckett, Julia A Heneghan, Katherine Biagas, Erin F Carlton, Mary E Hartman, Lauren Yagiela, Kelly N Michelson, Joseph C Manning, Debbie A Long, Jan Hau Lee, Beth S Slomine, Sue R Beers, Trevor Hall, Brenda M Morrow, Kathleen Meert, Maria Del Pilar Arias Lopez, Hennie Knoester, Amy Houtrow, Lenora Olson, Lisa Steele, Luregn J Schlapbach, Randall S Burd, Ruth Grosskreuz, Warwick Butt, Ericka L Fink, R Scott Watson
OBJECTIVES: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. DESIGN: A modified Delphi consensus process. SETTING: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research ( n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators...
November 1, 2022: Pediatric Critical Care Medicine
#39
JOURNAL ARTICLE
S A Koerber, R C Kroener, K Dendl, C Kratochwil, C A Fink, J Ristau, E Winter, K Herfarth, G Hatiboglu, M Hohenfellner, U Haberkorn, J Debus, F L Giesel
PURPOSE: Due to limited imaging options, the visualization of a local relapse of prostate cancer used to pose a considerable challenge. However, since the integration of 18 F-PSMA-1007-PET/CT into the clinic, a relapsed tumor can now easily be detected by hybrid imaging. The present study aimed to evaluate and map the allocate relapse in a large cohort of prostate cancer patients focusing on individual patient management conclusions for radiation therapy. PROCEDURES: The current study included 135 men with prostate cancer after primary treatment who underwent 18 F-PSMA-1007-PET/CT due to biochemical relapse detecting a local relapse...
August 23, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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JOURNAL ARTICLE
Isabelle Grootes, Renske Keeman, Fiona M Blows, Roger L Milne, Graham G Giles, Anthony J Swerdlow, Peter A Fasching, Mustapha Abubakar, Irene L Andrulis, Hoda Anton-Culver, Matthias W Beckmann, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Ignacio Briceno, Barbara Burwinkel, Nicola J Camp, Jose E Castelao, Ji-Yeob Choi, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Mikael Eriksson, Kristina Ernst, D Gareth Evans, Jonine D Figueroa, Visnja Fink, Giuseppe Floris, Stephen Fox, Marike Gabrielson, Manuela Gago-Dominguez, José A García-Sáenz, Anna González-Neira, Lothar Haeberle, Christopher A Haiman, Per Hall, Ute Hamann, Elaine F Harkness, Mikael Hartman, Alexander Hein, Maartje J Hooning, Ming-Feng Hou, Sacha J Howell, Hidemi Ito, Anna Jakubowska, Wolfgang Janni, Esther M John, Audrey Jung, Daehee Kang, Vessela N Kristensen, Ava Kwong, Diether Lambrechts, Jingmei Li, Jan Lubiński, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Nur Aishah Mohd Taib, Anna Marie Mulligan, Heli Nevanlinna, William G Newman, Kenneth Offit, Ana Osorio, Sue K Park, Tjoung-Won Park-Simon, Alpa V Patel, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Gad Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Andreas Schneeweiss, Fabienne Schochter, Minouk J Schoemaker, Chen-Yang Shen, Rana Shibli, Peter Sinn, William J Tapper, Essa Tawfiq, Soo Hwang Teo, Lauren R Teras, Diana Torres, Celine M Vachon, Carolien H M van Deurzen, Camilla Wendt, Justin A Williams, Robert Winqvist, Mark Elwood, Marjanka K Schmidt, Montserrat García-Closas, Paul D P Pharoah
BACKGROUND: Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2). METHOD: The prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium...
August 4, 2022: European Journal of Cancer
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