keyword
MENU ▼
Read by QxMD icon Read
search

weiss ph

keyword
https://www.readbyqxmd.com/read/29138485/evaluating-the-impact-of-domestication-and-captivity-on-the-horse-gut-microbiome
#1
Jessica L Metcalf, Se Jin Song, James T Morton, Sophie Weiss, Andaine Seguin-Orlando, Frédéric Joly, Claudia Feh, Pierre Taberlet, Eric Coissac, Amnon Amir, Eske Willerslev, Rob Knight, Valerie McKenzie, Ludovic Orlando
The mammal gut microbiome, which includes host microbes and their respective genes, is now recognized as an essential second genome that provides critical functions to the host. In humans, studies have revealed that lifestyle strongly influences the composition and diversity of the gastrointestinal microbiome. We hypothesized that these trends in humans may be paralleled in mammals subjected to anthropogenic forces such as domestication and captivity, in which diets and natural life histories are often greatly modified...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29099657/express-medication-and-patient-factors-associated-with-adherence-to-pulmonary-hypertension-targeted-therapies
#2
Duncan Grady, Marjorie Weiss, Jules Hernandez-Sanchez, Joanna Pepke-Zaba
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/29079517/cathepsin-b-mediated-activation-of-trypsinogen-in-endocytosing-macrophages-increases-severity-of-pancreatitis-in-mice
#3
Matthias Sendler, Frank-Ulrich Weiss, Janine Golchert, Georg Homuth, Cindy van den Brandt, Ujjwal M Mahajan, Lars-Ivo Partecke, Paula Döring, Ilya Gukovsky, Anna S Gukovskaya, Preshit R Wagh, Markus M Lerch, Julia Mayerle
BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response. We investigated how these processes interact during severe pancreatitis in mice. METHODS: Pancreatitis was induced in C57Bl/6 wild-type (control), cathepsin B-knockout, and cathepsin L-knockout mice by partial pancreatic duct ligation with supramaximal caerulein injection, or by repetitive supramaximal caerulein injections alone...
October 24, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29064707/l-carnosine-derived-fmoc-tripeptides-forming-ph-sensitive-and-proteolytically-stable-supramolecular-hydrogels
#4
Rita Das Mahapatra, Joykrishna Dey, Richard G Weiss
A series of β-amino acid containing tripeptides has been designed and synthesized in order to develop oligopeptide-based, thermoreversible, pH-sensitive, and proteolytically stable hydrogels. The Fmoc [N-(fluorenyl-9-methoxycarbonyl)]-protected tripeptides were found to produce hydrogels in both pH 7 and 2 buffers at a very low concentration (<0.2% w/v). It has been shown that the Fmoc group plays an important role in the gelation process. Also a dependence of gelation ability on hydrophobicity of the side chain of the Fmoc-protected α-amino acid was observed...
November 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29038582/direct-visualization-of-critical-hydrogen-atoms-in-a-pyridoxal-5-phosphate-enzyme
#5
Steven Dajnowicz, Ryne C Johnston, Jerry M Parks, Matthew P Blakeley, David A Keen, Kevin L Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C Mueser
Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse chemical transformations. They promote various reactions by modulating the electronic states of PLP through weak interactions in the active site. Neutron crystallography has the unique ability of visualizing the nuclear positions of hydrogen atoms in macromolecules. Here we present a room-temperature neutron structure of a homodimeric PLP-dependent enzyme, aspartate aminotransferase, which was reacted in situ with α-methylaspartate...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29021534/quorum-sensing-integrates-environmental-cues-cell-density-and-cell-history-to-control-bacterial-competence
#6
Stefany Moreno-Gámez, Robin A Sorg, Arnau Domenech, Morten Kjos, Franz J Weissing, G Sander van Doorn, Jan-Willem Veening
Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28972952/impact-of-a-ph-5-oil-in-water-emulsion-on-skin-surface-ph
#7
Theresa Fürtjes, Katharina T Weiss, Alexander Filbry, Frank Rippke, Stephan Schreml
BACKGROUND: Human skin surface has a physiologically acidic pH (pHss). In cases of increased pHss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pHss regeneration and stabilization. METHODS: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pHss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min...
October 4, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28936487/platelet-dense-granules-begin-to-selectively-accumulate-mepacrine-during-proplatelet-formation
#8
Hayley A Hanby, Jialing Bao, Ji-Yoon Noh, Danuta Jarocha, Mortimer Poncz, Mitchell J Weiss, Michael S Marks
Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as ADP and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activation, adhesion, and stabilization at sites of vascular damage. DGs are thought to fully mature within megakaryocytes (MKs) prior to platelet formation. Here we challenge this notion by exploiting vital fluorescent dyes to distinguish mildly acidic DGs from highly acidic compartments by microscopy in platelets and MKs...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/28898428/soil-co2-venting-as-one-of-the-mechanisms-for-tolerance-of-zn-deficiency-by-rice-in-flooded-soils
#9
Marie-Cecile Affholder, Dominik J Weiss, Matthias Wissuwa, Sarah E Johnson-Beebout, Guy J D Kirk
We sought to explain rice (Oryza sativa) genotype differences in tolerance of zinc (Zn) deficiency in flooded paddy soils and the counter-intuitive observation, made in earlier field experiments, that Zn uptake per plant increases with increasing planting density. We grew tolerant and intolerant genotypes in a Zn-deficient flooded soil at high and low planting densities and found (a) plant Zn concentrations and growth increased with planting density and more so in the tolerant genotype, whereas the concentrations of other nutrients decreased, indicating a specific effect on Zn uptake; (b) the effects of planting density and genotype on Zn uptake could only be explained if the plants induced changes in the soil to make Zn more soluble; and (c) the genotype and planting density effects were both associated with decreases in dissolved CO2 in the rhizosphere soil solution and resulting increases in pH...
September 12, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28815270/pre-analytic-evaluation-of-volumetric-absorptive-microsampling-and-integration-in-a-mass-spectrometry-based-metabolomics-workflow
#10
Chiara Volani, Giulia Caprioli, Giovanni Calderisi, Baldur B Sigurdsson, Johannes Rainer, Ivo Gentilini, Andrew A Hicks, Peter P Pramstaller, Guenter Weiss, Sigurdur V Smarason, Giuseppe Paglia
Volumetric absorptive microsampling (VAMS) is a novel approach that allows single-drop (10 μL) blood collection. Integration of VAMS with mass spectrometry (MS)-based untargeted metabolomics is an attractive solution for both human and animal studies. However, to boost the use of VAMS in metabolomics, key pre-analytical questions need to be addressed. Therefore, in this work, we integrated VAMS in a MS-based untargeted metabolomics workflow and investigated pre-analytical strategies such as sample extraction procedures and metabolome stability at different storage conditions...
October 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28755992/microgels-of-silylated-hpmc-as-a-multimodal-system-for-drug-co-encapsulation
#11
Mohamed Zayed, Corine Tourne-Peteilh, Michel Ramonda, Gildas Rethore, Pierre Weiss, Jean Martinez, Gilles Subra, Ahmad Mehdi, Jean-Marie Devoisselle, Philippe Legrand
Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles. Silylated hydrogels are alkoxysilane hybrid polymers that can be engaged in a sol-gel process, providing chemical cross linking in physiological conditions, and functionalized biocompatible hybrid materials. In the present work, microgels were prepared with silylated (hydroxypropyl)methyl cellulose (Si-HPMC) that was chemically cross linked in soft conditions of pH and temperature...
November 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28678284/aminoalcohols-and-benzoates-friends-or-foes-tuning-nuclearity-of-cu-ii-complexes-studies-of-their-structures-magnetism-and-catecholase-like-activities-as-well-as-performing-dft-and-tddft-studies
#12
Farasha Sama, Ashish Kumar Dhara, Muhammad Nadeem Akhtar, Yan-Cong Chen, Ming-Liang Tong, Istikhar A Ansari, Mukul Raizada, Musheer Ahmad, M Shahid, Zafar A Siddiqi
Herein, the coordination chemistry of a series of Cu(ii) complexes of various aminoalcohol and benzoate ligands was explored. The pH-dependent reactions of copper(ii) salts with propanolamine (Hpa), N-methyl diethanolamine (H2mdea), triethanolamine (H3tea), and (n)butyl-diethanolamine (H2budea) were carried out in the presence of various benzoates (benzoic acid, 2-hydroxy benzoic acid, 4-hydroxy benzoic acid, 3-methoxy benzoic acid, and 4-methoxy benzoic acid). The resulting complexes [Cu2(pa)2(benzoate)2] (1), [Cu2(pa)2(3-methoxybenzoate)2] (2), [Cu2(pa)2(4-methoxybenzoate)2] (3), [Cu2(H2tea)2(benzoate)2]·2H2O (4), [Cu2(H2tea)2(2-hydroxybenzoate)2]·2H2O (5), [Cu2(H3tea)2(4-hydroxybenzoate)2][Cu(Htea)2]·2H2O (6), [Cu(H2mdea)2][benzoate]2 (7), [Cu(H2mdea)2][4-methoxybenzoate]2 (8), [Cu(H2bdea)2][2-hydroxybenzoate]2 (9), [Cu2(benzoate)4(benzoic acid)2] (10), [Cu2(4-methoxybenzoate)4(CH3CN)2]·4CH3CN (11) and [Cu3(H2tea)2(benzoate)2(NO3)2] (12) were formed as mono-, di- or trinuclear entities depending upon the pH conditions of the reaction...
August 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28623867/a-validated-uhplc-ms-ms-method-for-the-measurement-of-riluzole-in-plasma-and-myocardial-tissue-samples
#13
Suzanne L Parker, Yarmarly C Guerra Valero, Jeffrey Lipman, Steven Weiss, Camilla Smith, Lyndal Russell, Paul Smith, Jason A Roberts, Steven C Wallis
Through blocking the cardiac persistent sodium current, riluzole has the potential to prevent myocardial damage post cardiac bypass surgery. A sensitive UHPLC-MS/MS method was developed and validated for quantitation of riluzole and 5-methoxypsoralen in human plasma and myocardial tissue homogenate using a liquid-liquid extraction with dichloromethane. The chromatographic separation was achieved using Shimadzu Shim-pack XR-ODS III, 2.0 × 50 mm, 1.6 μm column with a gradient mobile phase comprising methanol and ammonium acetate buffer pH 3...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28565944/linus-pauling-ph-d-1901-1994-from-chemical-bond-to-civilization
#14
Kenneth J Weiss
No abstract text is available yet for this article.
June 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28557249/dendritic-mesoporous-silica-nanoparticles-for-ph-stimuli-responsive-drug-delivery-of-tnf-alpha
#15
Arne Kienzle, Sven Kurch, Janine Schlöder, Carsten Berges, Robert Ose, Jonathan Schupp, Andrea Tuettenberg, Henning Weiss, Jennifer Schultze, Svenja Winzen, Meike Schinnerer, Kaloian Koynov, Markus Mezger, Nikolas K Haass, Wolfgang Tremel, Helmut Jonuleit
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune stimulatory cytokine and natural endotoxin that can induce necrosis and regression in solid tumors. However, systemic administration of TNF-α is not feasible due to its short half-life and acute toxicity, preventing its widespread use in cancer treatment. Dendritic mesoporous silica nanoparticles (DMSN) are used coated with a pH-responsive block copolymer gate system combining charged hyperbranched polyethylenimine and nonionic hydrophilic polyethylenglycol to encapsulate TNF-α and deliver it into various cancer cell lines and dendritic cells...
May 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28509730/american-college-of-critical-care-medicine-clinical-practice-parameters-for-hemodynamic-support-of-pediatric-and-neonatal-septic-shock
#16
Alan L Davis, Joseph A Carcillo, Rajesh K Aneja, Andreas J Deymann, John C Lin, Trung C Nguyen, Regina S Okhuysen-Cawley, Monica S Relvas, Ranna A Rozenfeld, Peter W Skippen, Bonnie J Stojadinovic, Eric A Williams, Tim S Yeh, Fran Balamuth, Joe Brierley, Allan R de Caen, Ira M Cheifetz, Karen Choong, Edward Conway, Timothy Cornell, Allan Doctor, Marc-Andre Dugas, Jonathan D Feldman, Julie C Fitzgerald, Heidi R Flori, James D Fortenberry, Ana Lia Graciano, Bruce M Greenwald, Mark W Hall, Yong Yun Han, Lynn J Hernan, Jose E Irazuzta, Elizabeth Iselin, Elise W van der Jagt, Howard E Jeffries, Saraswati Kache, Chhavi Katyal, Niranjan Tex Kissoon, Alexander A Kon, Martha C Kutko, Graeme MacLaren, Timothy Maul, Renuka Mehta, Fola Odetola, Kristine Parbuoni, Raina Paul, Mark J Peters, Suchitra Ranjit, Karin E Reuter-Rice, Eduardo J Schnitzler, Halden F Scott, Adalberto Torres, Jacki Weingarten-Abrams, Scott L Weiss, Jerry J Zimmerman, Aaron L Zuckerberg
OBJECTIVES: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock." DESIGN: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014)...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28490576/complement-c5a-functions-as-a-master-switch-for-the-ph-balance-in-neutrophils-exerting-fundamental-immunometabolic-effects
#17
Stephanie Denk, Miriam D Neher, David A C Messerer, Rebecca Wiegner, Bo Nilsson, Daniel Rittirsch, Kristina Nilsson-Ekdahl, Sebastian Weckbach, Anita Ignatius, Miriam Kalbitz, Florian Gebhard, Manfred E Weiss, Josef Vogt, Peter Radermacher, Jörg Köhl, John D Lambris, Markus S Huber-Lang
During sepsis, excessive activation of the complement system with generation of the anaphylatoxin C5a results in profound disturbances in crucial neutrophil functions. Moreover, because neutrophil activity is highly dependent on intracellular pH (pHi), we propose a direct mechanistic link between complement activation and neutrophil pHi In this article, we demonstrate that in vitro exposure of human neutrophils to C5a significantly increased pHi by selective activation of the sodium/hydrogen exchanger. Upstream signaling of C5a-mediated intracellular alkalinization was dependent on C5aR1, intracellular calcium, protein kinase C, and calmodulin, and downstream signaling regulated the release of antibacterial myeloperoxidase and lactoferrin...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28464079/effects-of-roughage-inclusion-and-particle-size-on-digestion-and-ruminal-fermentation-characteristics-of-beef-steers
#18
C P Weiss, W W Gentry, C M Meredith, B E Meyer, N A Cole, L O Tedeschi, F T McCollum, J S Jennings
Roughage is fed in finishing diets to promote ruminal health and decrease digestive upset, but the inclusion rate is limited because of the cost per unit of energy and feed management issues. Rumination behavior of cattle may be a means to standardize roughage in beef cattle finishing diets, and increasing the particle size of roughage could modulate the ruminal environment and aid in maintaining ruminal pH. Therefore, this experiment was conducted to determine the effects of corn stalk (CS) inclusion rate and particle size in finishing diets on digestibility, rumination, and ruminal fermentation characteristics of beef steers...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28453286/sugar-beet-extract-beta-vulgaris-l-as-a-new-natural-emulsifier-emulsion-formation
#19
Theo Ralla, Hanna Salminen, Matthias Edelmann, Corinna Dawid, Thomas Hofmann, Jochen Weiss
The interfacial and emulsion-forming properties of sugar beet extract (Beta vulgaris L.) were examined and compared to a Quillaja extract that is widely used within the food industry. We investigated the influence of extract concentration on surface activity at oil-water and air-water interfaces and on the formation of oil-in-water emulsions (10% w/w, pH 7). Sugar beet extract reduced the interfacial tension up to 38% at the oil-water interface, and the surface tension up to 33% at the air-water surface. The generated emulsions were negatively charged (ζ ≈ -46 mV) and had the smallest particle sizes (d43) of ∼1...
May 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28388526/sepsis-associated-in-hospital-cardiac-arrest-epidemiology-pathophysiology-and-potential-therapies
#20
REVIEW
Ryan W Morgan, Julie C Fitzgerald, Scott L Weiss, Vinay M Nadkarni, Robert M Sutton, Robert A Berg
Sepsis-associated cardiac arrest is a relatively common occurrence with especially poor outcomes. Of the greater than 200,000 in-hospital cardiac arrests that occur in the United States annually, between 30,000 and 60,000 occur in patients with underlying sepsis. These patients are less likely to survive than cardiac arrest victims without sepsis. In this review, we discuss the epidemiology of sepsis-associated in-hospital cardiac arrest in adults and children, the relevant physiology responsible for its pathogenesis and poor outcomes, and potential therapeutic interventions based on this pathophysiology...
August 2017: Journal of Critical Care
keyword
keyword
27381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"