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JOURNAL ARTICLE
Nils Richter, Stefanie Brand, Nils Nellessen, Julian Dronse, Hannes Gramespacher, Maximilian H T Schmieschek, Gereon R Fink, Juraj Kukolja, Oezguer A Onur
INTRODUCTION: In clinical practice, differentiating between age-related gray matter (GM) atrophy and neurodegeneration-related atrophy at early disease stages, such as mild cognitive impairment (MCI), remains challenging. We hypothesized that fined-grained adjustment for age effects and using amyloid-negative reference subjects could increase classification accuracy. METHODS: T1-weighted magnetic resonance imaging (MRI) data of 131 cognitively normal (CN) individuals and 91 patients with MCI from the Alzheimer's disease neuroimaging initiative (ADNI) characterized concerning amyloid status, as well as 19 CN individuals and 19 MCI patients from an independent validation sample were segmented, spatially normalized and analyzed in the framework of voxel-based morphometry (VBM)...
September 9, 2023: NeuroImage: Clinical
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JOURNAL ARTICLE
Karim M Omambac, Marko A Kriegel, Marin Petrović, Birk Finke, Christian Brand, Frank J Meyer Zu Heringdorf, Michael Horn-von Hoegen
The CVD growth of bielemental 2D-materials by using molecular precursors involves complex formation kinetics taking place at the surface and sometimes also subsurface regions of the substrate. Competing microscopic processes fundamentally limit the parameter space for optimal growth of the desired material. Kinetic limitations for diffusion and nucleation cause a high density of small domains and grain boundaries. These are usually overcome by increasing the growth temperature and decreasing the growth rate...
September 7, 2023: ACS Nano
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JOURNAL ARTICLE
Bethany F Laatsch, Michael Brandt, Brianna Finke, Carl J Fossum, Miles J Wackett, Harrison R Lowater, Alex Narkiewicz-Jodko, Christine N Le, Thao Yang, Elizabeth M Glogowski, Scott C Bailey-Hartsel, Sudeep Bhattacharyya, Sanchita Hati
Polyethylene glycol (PEG) is a polyether compound commonly used in biological research and medicine because it is biologically inert. This simple polymer exists in variable chain lengths (and molecular weights). As they are devoid of any contiguous π-system, PEGs are expected to lack fluorescence properties. However, recent studies suggested the occurrence of fluorescence properties in non-traditional fluorophores like PEGs. Herein, a thorough investigation has been conducted to explore if PEG 20k fluoresces...
April 18, 2023: ACS Omega
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JOURNAL ARTICLE
Seavchou Laut, Saranya Poapolathep, Onuma Piasai, Sujinda Sommai, Nattawut Boonyuen, Mario Giorgi, Zhaowei Zhang, Johanna Fink-Gremmels, Amnart Poapolathep
The study focused on the examination of the different fungal species isolated from commercial rice samples, applying conventional culture techniques, as well as different molecular and phylogenic analyses to confirm phenotypic identification. Additionally, the mycotoxin production and contamination were analyzed using validated liquid chromatography-tandem mass spectrometry (LC-MS/MS). In total, 40 rice samples were obtained covering rice berry, red jasmine rice, brown rice, germinated brown rice, and white rice...
January 20, 2023: Foods (Basel, Switzerland)
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JOURNAL ARTICLE
Martin Wepler, Jonathan M Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P Tuckermann, Sabine Vettorazzi
Introduction: We previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim ) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, which leads to tissue hypoxia and inflammation with risk of organ failure. Lung co-morbidities like chronic obstructive pulmonary disease (COPD) can aggravate tissue hypoxia via alveolar hypoxia. The most common cause for COPD is cigarette smoke (CS) exposure...
2022: Frontiers in Immunology
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JOURNAL ARTICLE
Paul Y Kim, Yige Gao, Zachary Fink, Alexander E Ribbe, David A Hoagland, Thomas P Russell
A Gibbs monolayer of jammed, or nearly jammed, spherical nanoparticles was imaged at a liquid surface in real time by in-situ scanning electron microscopy performed at the single-particle level. At nanoparticle areal fractions above that for the onset of two-dimensional crystallization, structural reorganizations of the mobile polymer-coated particles were visualized after a stepwise areal compression. When the compression was small, slow shearing near dislocations and reconfigured nanoparticle bonding were observed at crystal grain boundaries...
March 24, 2022: ACS Nano
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JOURNAL ARTICLE
Nele Demeyere, Marleen Haupt, Sam S Webb, Lea Strobel, Elise T Milosevich, Margaret J Moore, Hayley Wright, Kathrin Finke, Mihaela D Duta
Here, we present the Oxford Cognitive Screen-Plus, a computerised tablet-based screen designed to briefly assess domain-general cognition and provide more fine-grained measures of memory and executive function. The OCS-Plus was designed to sensitively screen for cognitive impairments and provide a differentiation between memory and executive deficits. The OCS-Plus contains 10 subtasks and requires on average 24 min to complete. In this study, 320 neurologically healthy ageing participants (age M = 62.66, SD = 13...
April 12, 2021: Scientific Reports
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JOURNAL ARTICLE
Graham Cooper, Sebastian Hirsch, Michael Scheel, Alexander U Brandt, Friedemann Paul, Carsten Finke, Philipp Boehm-Sturm, Stefan Hetzer
Using quantitative multi-parameter mapping (MPM), studies can investigate clinically relevant microstructural changes with high reliability over time and across subjects and sites. However, long acquisition times (20 min for the standard 1-mm isotropic protocol) limit its translational potential. This study aimed to evaluate the sensitivity gain of a fast 1.6-mm isotropic MPM protocol including post-processing optimized for longitudinal clinical studies. 6 healthy volunteers (35±7 years old; 3 female) were scanned at 3T to acquire the following whole-brain MPM maps with 1...
2020: Frontiers in Neuroscience
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JOURNAL ARTICLE
Javier Brum, Jean Luc Gennisson, Mathias Fink, Arnaud Tourin, Xiaoping Jia
We present an experimental investigation of Rayleigh-like wave propagation along the surface of a dense granular suspension. Using an ultrafast ultrasound scanner, we monitor the softening of the shear modulus via the Rayleigh-like wave velocity slowdown in the optically opaque medium as the driving amplitude increases. For such nonlinear behavior two regimes are found when increasingthe driving amplitude progressively: First, we observe a significant shear modulus weakening due to the microslip on the contact level without macroscopic rearrangements of grains...
April 2019: Physical Review. E
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JOURNAL ARTICLE
Hannah Muecke, Nils Richter, Boris von Reutern, Juraj Kukolja, Gereon R Fink, Oezguer A Onur
Objective : In subjects with mild cognitive impairment (MCI), interference during memory consolidation may further degrade subsequent recall of newly learned information. We investigated whether spatial and object memory are differentially susceptible to interference. Method : Thirty-nine healthy young subjects, 39 healthy older subjects, and 12 subjects suffering from MCI encoded objects and their spatial position on a 4-by-5 grid. Encoding was followed by either: (i) a pause; (ii) an interference task immediately following encoding; or (iii) an interference task following encoding after a 6-min delay...
2018: Frontiers in Aging Neuroscience
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JOURNAL ARTICLE
G Wilma van Esse, Agatha Walla, Andreas Finke, Maarten Koornneef, Ales Pecinka, Maria von Korff
The complex nature of crop genomes has long prohibited the efficient isolation of agronomically relevant genes. However, recent advances in next-generation sequencing technologies provide new ways to accelerate fine-mapping and gene isolation in crops. We used RNA sequencing of allelic six-rowed spike3 ( vrs3 ) mutants with altered spikelet development for gene identification and functional analysis in barley ( Hordeum vulgare ). Variant calling in two allelic vrs3 mutants revealed that VRS3 encodes a putative histone Lys demethylase with a conserved zinc finger and Jumonji C and N domain...
August 2017: Plant Physiology
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JOURNAL ARTICLE
Jesper G Corneliussen, Gloria R Leon, Anders Kjærgaard, Birgit A Fink, Noah C Venables
BACKGROUND: The study of personality traits, personal values, and the emergence of conflicts within groups performing in an isolated, confined, and extreme environment (ICE) may provide insights helpful for the composition and support of space crews for long duration missions. METHODS: Studied pre/post and over the 2-yr period of the investigation were 10 Danish military personnel deployed to stations in Greenland on a 26-mo staggered rotation. Subjects completed the NEO PI-R, Triarchic Psychopathy Measure, and Portrait Values Questionnaire, and participated in structured interviews...
June 1, 2017: Aerospace Medicine and Human Performance
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JOURNAL ARTICLE
N Otto, S Platz, T Fink, M Wutscherk, U Menzel
One key technology to eliminate organic micropollutants (OMP) from wastewater effluent is adsorption using powdered activated carbon (PAC). To avoid a discharge of highly loaded PAC particles into natural water bodies a separation stage has to be implemented. Commonly large settling tanks and flocculation filters with the application of coagulants and flocculation aids are used. In this study, a multi-hydrocyclone classifier with a downstream cloth filter has been investigated on a pilot plant as a space-saving alternative with no need for a dosing of chemical additives...
2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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JOURNAL ARTICLE
G Filacchione, M C De Sanctis, F Capaccioni, A Raponi, F Tosi, M Ciarniello, P Cerroni, G Piccioni, M T Capria, E Palomba, G Bellucci, S Erard, D Bockelee-Morvan, C Leyrat, G Arnold, M A Barucci, M Fulchignoni, B Schmitt, E Quirico, R Jaumann, K Stephan, A Longobardo, V Mennella, A Migliorini, E Ammannito, J Benkhoff, J P Bibring, A Blanco, M I Blecka, R Carlson, U Carsenty, L Colangeli, M Combes, M Combi, J Crovisier, P Drossart, T Encrenaz, C Federico, U Fink, S Fonti, W H Ip, P Irwin, E Kuehrt, Y Langevin, G Magni, T McCord, L Moroz, S Mottola, V Orofino, U Schade, F Taylor, D Tiphene, G P Tozzi, P Beck, N Biver, L Bonal, J-Ph Combe, D Despan, E Flamini, M Formisano, S Fornasier, A Frigeri, D Grassi, M S Gudipati, D Kappel, F Mancarella, K Markus, F Merlin, R Orosei, G Rinaldi, M Cartacci, A Cicchetti, S Giuppi, Y Hello, F Henry, S Jacquinod, J M Reess, R Noschese, R Politi, G Peter
Although water vapour is the main species observed in the coma of comet 67P/Churyumov-Gerasimenko and water is the major constituent of cometary nuclei, limited evidence for exposed water-ice regions on the surface of the nucleus has been found so far. The absence of large regions of exposed water ice seems a common finding on the surfaces of many of the comets observed so far. The nucleus of 67P/Churyumov-Gerasimenko appears to be fairly uniformly coated with dark, dehydrated, refractory and organic-rich material...
January 21, 2016: Nature
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JOURNAL ARTICLE
Thomas Tietze, Patrick Audehm, Yu-Chun Chen, Gisela Schütz, Boris B Straumal, Svetlana G Protasova, Andrey A Mazilkin, Petr B Straumal, Thomas Prokscha, Hubertus Luetkens, Zaher Salman, Andreas Suter, Brigitte Baretzky, Karin Fink, Wolfgang Wenzel, Denis Danilov, Eberhard Goering
Diamagnetic oxides can, under certain conditions, become ferromagnetic at room temperature and therefore are promising candidates for future material in spintronic devices. Contrary to early predictions, doping ZnO with uniformly distributed magnetic ions is not essential to obtain ferromagnetic samples. Instead, the nanostructure seems to play the key role, as room temperature ferromagnetism was also found in nanograined, undoped ZnO. However, the origin of room temperature ferromagnetism in primarily non-magnetic oxides like ZnO is still unexplained and a controversial subject within the scientific community...
2015: Scientific Reports
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JOURNAL ARTICLE
Peyman Akbari, Saskia Braber, Hendrik Gremmels, Pim J Koelink, Kim A T Verheijden, Johan Garssen, Johanna Fink-Gremmels
Disintegration of the colonic epithelial barrier is considered a key event in the initiation and progression of inflammatory bowel and celiac disease. As the primary etiology of these diseases remains unknown, we hypothesized that the trichothecene deoxynivalenol (DON), a fungal metabolite found in grain-based human diets, might be one of the triggers resulting in an impairment of the intestinal tight junction network preceding an inflammatory response. Using horizontal impedance measurements, we demonstrate that DON disintegrates a human Caco-2 cell monolayer within <1 h after exposure to concentrations as low as 1...
June 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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JOURNAL ARTICLE
E Stöger, C Fink, M Pfosser, E Heberle-Bors
Direct delivery of DNA into embryogenic pollen was used to produce transgenic plants in tobacco. A plasmid bearing the ß-glucuronidase (GUS) marker gene in fusion with the 35S-promoter was introduced by microprojectile bombardment into mid-binucleate pollen of Nicotiana tabacum that had been induced to form embryos by a starvation treatment. In cytochemical expression assays, 5 out of 10(4) pollen grains were GUS(+). Visual selection by staining with a non-lethal substrate for GUS was used to manually isolate transformed embryos...
February 1995: Plant Cell Reports
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JOURNAL ARTICLE
Ryan C Fink, Jackie M Popowski, Jon E Anderson, Johanna L Dahlberg, Sudha Kalyanikutty, Grant I Crawford, Alfredo Dicostanzo, Ryan B Cox, Francisco Diez-Gonzalez
Escherichia coli O157 is a foodborne pathogen that can be transmitted by contaminated ground beef and is shed naturally in cattle feces. Recent reports indicated that feeding distillers' grains (DG) to cattle increased fecal shedding and prevalence of E. coli O157. In Minnesota, feeding DG with solubles (DGS) to livestock became widespread within the last 10 years, but there is no report about the prevalence of E. coli O157 in beef cattle in this state. This study was undertaken to survey the fecal prevalence of E...
June 2013: Foodborne Pathogens and Disease
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JOURNAL ARTICLE
Presence and biological activity of antibiotics used in fuel ethanol and corn co-product production.
D M Paulus Compart, A M Carlson, G I Crawford, R C Fink, F Diez-Gonzalez, A Dicostanzo, G C Shurson
Antibiotics are used in ethanol production to control bacteria from competing with yeast for nutrients during starch fermentation. However, there is no published scientific information on whether antibiotic residues are present in distillers grains (DG), co-products from ethanol production, or whether they retain their biological activity. Therefore, the objectives of this study were to quantify concentrations of various antibiotic residues in DG and determine whether residues were biologically active. Twenty distillers wet grains and 20 distillers dried grains samples were collected quarterly from 9 states and 43 ethanol plants in the United States...
May 2013: Journal of Animal Science
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REVIEW
Shannon W Finks, Anita Airee, Sheryl L Chow, Tracy E Macaulay, Michael P Moranville, Kelly C Rogers, Toby C Trujillo
Lifestyle modifications, particularly diet, are a key component to the reduction of cardiovascular events. Diets high in carbohydrates and saturated fat have been shown to negatively affect blood cholesterol, thereby increasing the risk for cardiovascular disease (CVD). Dietary interventions that emphasize the consumption of whole grains, fruits, and vegetables have been shown to be successful in reducing cardiovascular risk. Clinical pharmacist practitioners need to be knowledgeable regarding lifestyle modifications, specifically dietary issues, to develop a comprehensive, effective, and evidence-based plan for patients who are either at risk for or who have established CVD...
April 2012: Pharmacotherapy
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