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G Wilma van Esse, Agatha Walla, Andreas Finke, Maarten Koornneef, Ales Pecinka, Maria von Korff
The complex nature of crop genomes has long prohibited the efficient isolation of agronomically relevant genes. However, recent advances in next-generation sequencing technologies provide new ways to accelerate fine-mapping and gene isolation in crops. We used RNA sequencing of allelic six-rowed spike3 ( vrs3 ) mutants with altered spikelet development for gene identification and functional analysis in barley ( Hordeum vulgare ). Variant calling in two allelic vrs3 mutants revealed that VRS3 encodes a putative histone Lys demethylase with a conserved zinc finger and Jumonji C and N domain...
August 2017: Plant Physiology
Jesper G Corneliussen, Gloria R Leon, Anders Kjærgaard, Birgit A Fink, Noah C Venables
BACKGROUND: The study of personality traits, personal values, and the emergence of conflicts within groups performing in an isolated, confined, and extreme environment (ICE) may provide insights helpful for the composition and support of space crews for long duration missions. METHODS: Studied pre/post and over the 2-yr period of the investigation were 10 Danish military personnel deployed to stations in Greenland on a 26-mo staggered rotation. Subjects completed the NEO PI-R, Triarchic Psychopathy Measure, and Portrait Values Questionnaire, and participated in structured interviews...
June 1, 2017: Aerospace Medicine and Human Performance
N Otto, S Platz, T Fink, M Wutscherk, U Menzel
One key technology to eliminate organic micropollutants (OMP) from wastewater effluent is adsorption using powdered activated carbon (PAC). To avoid a discharge of highly loaded PAC particles into natural water bodies a separation stage has to be implemented. Commonly large settling tanks and flocculation filters with the application of coagulants and flocculation aids are used. In this study, a multi-hydrocyclone classifier with a downstream cloth filter has been investigated on a pilot plant as a space-saving alternative with no need for a dosing of chemical additives...
2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
G Filacchione, M C De Sanctis, F Capaccioni, A Raponi, F Tosi, M Ciarniello, P Cerroni, G Piccioni, M T Capria, E Palomba, G Bellucci, S Erard, D Bockelee-Morvan, C Leyrat, G Arnold, M A Barucci, M Fulchignoni, B Schmitt, E Quirico, R Jaumann, K Stephan, A Longobardo, V Mennella, A Migliorini, E Ammannito, J Benkhoff, J P Bibring, A Blanco, M I Blecka, R Carlson, U Carsenty, L Colangeli, M Combes, M Combi, J Crovisier, P Drossart, T Encrenaz, C Federico, U Fink, S Fonti, W H Ip, P Irwin, E Kuehrt, Y Langevin, G Magni, T McCord, L Moroz, S Mottola, V Orofino, U Schade, F Taylor, D Tiphene, G P Tozzi, P Beck, N Biver, L Bonal, J-Ph Combe, D Despan, E Flamini, M Formisano, S Fornasier, A Frigeri, D Grassi, M S Gudipati, D Kappel, F Mancarella, K Markus, F Merlin, R Orosei, G Rinaldi, M Cartacci, A Cicchetti, S Giuppi, Y Hello, F Henry, S Jacquinod, J M Reess, R Noschese, R Politi, G Peter
Although water vapour is the main species observed in the coma of comet 67P/Churyumov-Gerasimenko and water is the major constituent of cometary nuclei, limited evidence for exposed water-ice regions on the surface of the nucleus has been found so far. The absence of large regions of exposed water ice seems a common finding on the surfaces of many of the comets observed so far. The nucleus of 67P/Churyumov-Gerasimenko appears to be fairly uniformly coated with dark, dehydrated, refractory and organic-rich material...
January 21, 2016: Nature
Thomas Tietze, Patrick Audehm, Yu-Chun Chen, Gisela Schütz, Boris B Straumal, Svetlana G Protasova, Andrey A Mazilkin, Petr B Straumal, Thomas Prokscha, Hubertus Luetkens, Zaher Salman, Andreas Suter, Brigitte Baretzky, Karin Fink, Wolfgang Wenzel, Denis Danilov, Eberhard Goering
Diamagnetic oxides can, under certain conditions, become ferromagnetic at room temperature and therefore are promising candidates for future material in spintronic devices. Contrary to early predictions, doping ZnO with uniformly distributed magnetic ions is not essential to obtain ferromagnetic samples. Instead, the nanostructure seems to play the key role, as room temperature ferromagnetism was also found in nanograined, undoped ZnO. However, the origin of room temperature ferromagnetism in primarily non-magnetic oxides like ZnO is still unexplained and a controversial subject within the scientific community...
2015: Scientific Reports
Peyman Akbari, Saskia Braber, Hendrik Gremmels, Pim J Koelink, Kim A T Verheijden, Johan Garssen, Johanna Fink-Gremmels
Disintegration of the colonic epithelial barrier is considered a key event in the initiation and progression of inflammatory bowel and celiac disease. As the primary etiology of these diseases remains unknown, we hypothesized that the trichothecene deoxynivalenol (DON), a fungal metabolite found in grain-based human diets, might be one of the triggers resulting in an impairment of the intestinal tight junction network preceding an inflammatory response. Using horizontal impedance measurements, we demonstrate that DON disintegrates a human Caco-2 cell monolayer within <1 h after exposure to concentrations as low as 1...
June 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
E Stöger, C Fink, M Pfosser, E Heberle-Bors
Direct delivery of DNA into embryogenic pollen was used to produce transgenic plants in tobacco. A plasmid bearing the ß-glucuronidase (GUS) marker gene in fusion with the 35S-promoter was introduced by microprojectile bombardment into mid-binucleate pollen of Nicotiana tabacum that had been induced to form embryos by a starvation treatment. In cytochemical expression assays, 5 out of 10(4) pollen grains were GUS(+). Visual selection by staining with a non-lethal substrate for GUS was used to manually isolate transformed embryos...
February 1995: Plant Cell Reports
Ryan C Fink, Jackie M Popowski, Jon E Anderson, Johanna L Dahlberg, Sudha Kalyanikutty, Grant I Crawford, Alfredo Dicostanzo, Ryan B Cox, Francisco Diez-Gonzalez
Escherichia coli O157 is a foodborne pathogen that can be transmitted by contaminated ground beef and is shed naturally in cattle feces. Recent reports indicated that feeding distillers' grains (DG) to cattle increased fecal shedding and prevalence of E. coli O157. In Minnesota, feeding DG with solubles (DGS) to livestock became widespread within the last 10 years, but there is no report about the prevalence of E. coli O157 in beef cattle in this state. This study was undertaken to survey the fecal prevalence of E...
June 2013: Foodborne Pathogens and Disease
D M Paulus Compart, A M Carlson, G I Crawford, R C Fink, F Diez-Gonzalez, A Dicostanzo, G C Shurson
Antibiotics are used in ethanol production to control bacteria from competing with yeast for nutrients during starch fermentation. However, there is no published scientific information on whether antibiotic residues are present in distillers grains (DG), co-products from ethanol production, or whether they retain their biological activity. Therefore, the objectives of this study were to quantify concentrations of various antibiotic residues in DG and determine whether residues were biologically active. Twenty distillers wet grains and 20 distillers dried grains samples were collected quarterly from 9 states and 43 ethanol plants in the United States...
May 2013: Journal of Animal Science
Shannon W Finks, Anita Airee, Sheryl L Chow, Tracy E Macaulay, Michael P Moranville, Kelly C Rogers, Toby C Trujillo
Lifestyle modifications, particularly diet, are a key component to the reduction of cardiovascular events. Diets high in carbohydrates and saturated fat have been shown to negatively affect blood cholesterol, thereby increasing the risk for cardiovascular disease (CVD). Dietary interventions that emphasize the consumption of whole grains, fruits, and vegetables have been shown to be successful in reducing cardiovascular risk. Clinical pharmacist practitioners need to be knowledgeable regarding lifestyle modifications, specifically dietary issues, to develop a comprehensive, effective, and evidence-based plan for patients who are either at risk for or who have established CVD...
April 2012: Pharmacotherapy
A Rex, H Fink, M Skingle, C A Marsden
Previous studies have shown that guinea-pigs handled daily from birth exhibit on exposure to the elevated plus maze similar behaviour to rats and increased cortical extracellular 5-HT determined by in vivo microdialysis. The present study investigates the effects of a non-selective 5-HT(1) agonist 5-carboxamidotryptamine (5-CT) and the 5-HT(1D) antagonist GR 127935 on behaviour and the release of cortical extracellular 5-HT both in a familiar environment and on exposure to the elevated plus maze. In the familiar environment of the home cage GR 127935 (0...
January 1996: Journal of Psychopharmacology
R Rosie, E Thomson, M Blum, J L Roberts, G Fink
Oestradiol-17ß, in its positive feedback mode, as well as stimulating the release of luteinizing hormone-releasing hormone. (LHRH), also stimulates LHRH mRNA synthesis in medial preoptic neurons. Our aim was to determine whether the action of oestradiol might be mediated in part by inhibiting arcuate proopiomelanocortin (POMC) neurons which terminate on LHRH neurons. Female rats were ovariectomized at about 1000 h of dioestrus, given a subcutaneous injection of oil or oestradiol benzoate and killed at 1600 h the same day (presumptive dioestrus), presumptive pro-oestrus and oestrus and at 1000 h of presumptive pro-oestrus...
October 1992: Journal of Neuroendocrinology
E J Schoevers, J Fink-Gremmels, B Colenbrander, B A J Roelen
Deoxynivalenol (DON, vomitoxin) is a secondary metabolite and mycotoxin produced by Fusarium species that occurs with a high prevalence in cereals and grains intended for human and animal consumption. Pigs are considered to be the most sensitive animal species and exposure to DON results in reduced feed intake, reduced performance and cause alterations in the expression of markers of inflammation and cell cycle regulation. The objective of this study was to determine how DON possibly affects the oocyte developmental potential in vitro at concentrations which correspond to those observed in practice...
October 1, 2010: Theriogenology
B E Sumner, G Fink
The aim of the present study was to determine the effect of estradiol-17beta, in its positive feedback mode for the release of prolactin and luteinizing hormone (LH), on gene expression of 5-hydroxytryptamine (5-HT) and dopamine receptors. Gene expression was determined by measurement of the levels of receptor mRNA by in situ hybridization in brain sections from adult female rats. The animals were ovariectomized under halothane anesthesia on the morning of diestrus, given a sc injection of either estradiol benzoate (EB) or oil (vehicle), and killed between 1600-1700 h of the next day, presumptive proestrus...
February 1993: Molecular and Cellular Neurosciences
Benjamin T Andrews, Shachi Gosavi, John M Finke, José N Onuchic, Patricia A Jennings
Recent experimental studies suggest that the mature GFP has an unconventional landscape composed of an early folding event with a typical funneled landscape, followed by a very slow search and rearrangement step into the locked, active chromophore-containing structure. As we have shown previously, the substantial difference in time scales is what generates the observed hysteresis in thermodynamic folding. The interconversion between locked and the soft folding structures at intermediate denaturant concentrations is so slow that it is not observed under the typical experimental observation time...
August 26, 2008: Proceedings of the National Academy of Sciences of the United States of America
Michael J Wester, Sara N Pollock, Evangelos A Coutsias, Tharun Kumar Allu, Sorel Muresan, Tudor I Oprea
We have systematically enumerated graph representations of scaffold topologies for up to eight-ring molecules and four-valence atoms, thus providing coverage of the lower portion of the chemical space of small molecules (Pollock et al. J. Chem. Inf. Model., this issue). Here, we examine scaffold topology distributions for several databases: ChemNavigator and PubChem for commercially available chemicals, the Dictionary of Natural Products, a set of 2742 launched drugs, WOMBAT, a database of medicinal chemistry compounds, and two subsets of PubChem, "actives" and DSSTox comprising toxic substances...
July 2008: Journal of Chemical Information and Modeling
Henry S Ashbaugh, Harold W Hatch
In the absence of experimental assignments, the empirical charge/hydropathy correlation for the prediction of natively unfolded protein sequences (Uversky, V. N.; Gillespie, J. R.; Fink, A. L. Proteins: Struct., Funct., Genet. 2000, 41, 415-427) provides perhaps the most intuitive description of gross polypeptide conformation. The success of this correlation rests on an essential chain length independence of the boundary line between expanded and compact conformations, conversely stabilized by highly charged/weakly hydrophobic residues or weakly charged/highly hydrophobic residues, respectively...
July 23, 2008: Journal of the American Chemical Society
M Fink, R Mallart, F Cancre
It is pointed out that speckle noise can be reduced through the use of incoherent processing techniques. The theoretical limit for the SNR improvement when incoherent processing techniques are used is studied. The study leads to the concept of information grains. A simple technique for incoherent processing that is easy to implement and that allows a good physical understanding of the limitations of incoherent processing of pulse-echo signals is also studied. This technique does not require the division of the receiving aperture into many small coherent subelements, the scanning of the field as in spatial compounding, or the use of low-sensitivity CdS transducers...
1990: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Sandra R Wilson, Arlene Fink, Shinu Verghese, John C Beck, Khue Nguyen, Philip Lavori
OBJECTIVES: To evaluate a new alcohol-related risk score for research use. DESIGN: Using data from a previously reported trial of a screening and education system for older adults (Computerized Alcohol-Related Problems Survey), secondary analyses were conducted comparing the ability of two different measures of risk to detect post-intervention group differences: the original categorical outcome measure and a new, finely grained quantitative risk score based on the same research-based risk factors...
March 2007: Journal of the American Geriatrics Society
Hi-Jae Choi, Karl Zilles, Hartmut Mohlberg, Axel Schleicher, Gereon R Fink, Este Armstrong, Katrin Amunts
Anatomical studies in the macaque cortex and functional imaging studies in humans have demonstrated the existence of different cortical areas within the intraparietal sulcus (IPS). Such functional segregation, however, does not correlate with presently available architectonic maps of the human brain. This is particularly true for the classical Brodmann map, which is still widely used as an anatomical reference in functional imaging studies. The aim of this cytoarchitectonic mapping study was to use previously defined algorithms to determine whether consistent regions and borders can be found within the cortex of the anterior IPS in a population of 10 post-mortem human brains...
March 1, 2006: Journal of Comparative Neurology
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